RPSA Gene
protein-coding GIFtS : 63
GCID: GC03 P039448
ribosomal protein SA (Previous names: laminin receptor 1 (67kD, ribosomal protein SA) ) (Previous symbol: LAMR1 )
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Aliasesfor RPSA gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Ribosomal Protein SA 1 2 67LR2 3 LAMR11 2 3 5 LBP/P401 37LRP1 2 3 LRP/LR2 3 LAMBR2 3 5 NEM/1CHD42 3 LRP1 2 37 KDa Laminin Receptor2 SA1 2 40S Ribosomal Protein SA2 Laminin Receptor 1 (67kD, Ribosomal Protein SA)1 2 67kD, Ribosomal Protein SA2 P401 LBP2 Colon Carcinoma Laminin-Binding Protein2 3 LamR3 Laminin-Binding Protein Precursor P402 3 Laminin Binding Protein2 Multidrug Resistance-Associated Protein MGr1-Ag2 3 37 KDa Laminin Receptor Precursor3 37/67 KDa Laminin Receptor2 3 LamR3 67 KDa Laminin Receptor2 3 Laminin Receptor 13
Export aliases for RPSA gene to outside databases Previous GC identifer: GC03P039424
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Summariesfor RPSA gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for RPSA : Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: RSSA_HUMAN, P08865 Function : Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria Gene Wiki entry for RPSA (Ribosomal protein SA)
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genomic Viewsfor RPSA gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000003.11 NC_018914.1 NT_022517.18 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the RPSA gene promoter: AhR C/EBPbeta CBF-B CBF(2) CBF-C Arnt Other transcription factors Search SABiosciences Chromatin IP Primers for RPSA Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat RPSA
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 3p22.2 Ensembl cytogenetic band: 3p22.1 HGNC cytogenetic band: 3p21.3 RPSA Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 3 GeneLoc Exon Structure
GeneLoc location for GC03P039448: view genomic region
(about GC identifiers )
Start:
39,448,180 bp from pter
End:
39,454,033 bp from pter
Size:
5,854 bases
Orientation:
plus strand
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Proteinsfor RPSA gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: RSSA_HUMAN, P08865 (See
protein sequence )Recommended Name: 40S ribosomal protein SA Size : 295 amino acids; 32854 Da
Subunit : Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of asmall (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK (By similarity). Interacts with PRNP. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B
Subcellular location : Cell membrane. Cytoplasm. Nucleus (By similarity). Note=67LR is found at the surface of theplasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus (By similarity). Co-localizes with PPP1R16B in the cell membrane
Miscellaneous : This protein appears to have acquired a second function as a laminin receptor specifically in thevertebrate lineage
Miscellaneous : It is thought that in vertebrates 37/67 kDa laminin receptor acquired a dual function during evolution.It developed from the ribosomal protein SA, playing an essential role in the protein biosynthesis lacking any laminin binding activity, to a cell surface receptor with laminin binding activity
1 PDB 3D structure from and Proteopedia for RPSA :3BCH (3D)
 
Secondary accessions : P11085 P12030 Q16471 Q6IPD1 Q6IPD2 Q6NSD1 Q6NXQ8 Q86VC0Explore the universe of human proteins at neXtProt for RPSA: NX_P08865 Post-translational modifications:
Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association1
Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions (By similarity)1
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P08865 RPSA Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_001012321.1 NP_002286.2 ENSEMBL proteins: ENSP00000346067 ENSP00000410848 ENSP00000389351 ENSP00000396716 Reactome Protein details: P08865 Human Recombinant Protein Products: Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7 ): About this table
RPSA for ontologies About GeneDecksing RPSA Antibody Products: Assay Products for RPSA:
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Protein
Domains / Familiesfor RPSA gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
RPSA for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P08865 ProtoNet protein and cluster: P08865
1 Blocks protein family : IPB001865 Ribosomal protein S2 UniProtKB/Swiss-Prot: RSSA_HUMAN, P08865 Similarity : Belongs to the ribosomal protein S2P family
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Functionfor RPSA gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: RSSA_HUMAN, P08865 Function : Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RPSA (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RPSA (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): RPSA (NM_001012321 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPSA Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RPSA
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPSA
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view) : About this table
RPSA for ontologies About GeneDecksing 3 GenomeRNAi human phenotypes for RPSA :Animal Models: Mouse knock-out Rpsa tm1Ells for RPSA 6 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Rpsa) :
RPSA for phenotypes About GeneDecksing
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Pathways & Interactionsfor RPSA gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways  - 5/7 super-pathways (see all 7 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Synthesis of PB1-F2 2 Translation initiation complex formation 3 Metabolism of mRNA 4 Disease 5 Alpha6-Beta4 Integrin Signaling Pathway
Pathway sources See GeneCards unified pathways Show all pathways 1 GeneGo (Thomson Reuters) Pathway for RPSA 2 BioSystems Pathways for RPSA 5/32
Reactome Pathways for RPSA (see all 32 )1
Kegg Pathway (Kegg details for RPSA) :
RPSA for pathways About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RPSA STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/221 Interacting proteins for RPSA (P08865 2 , 3 ENSP00000346067 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 221 )About this table Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0000028 ribosomal small subunit assembly
IBA -- GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
TAS -- GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IBA -- GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IBA -- GO:0006407 rRNA export from nucleus
IBA --
RPSA for ontologies About GeneDecksing
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Drugs & Compoundsfor RPSA gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
RPSA for compounds About GeneDecksing Browse Tocris compounds for RPSA 10 Novoseek chemical compound relationships for RPSA gene About this table
Search CenterWatch for drugs/clinical trials and news about RPSA / RSSA
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Transcriptsfor RPSA gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for RPSA gene (2 alternative transcripts): NM_001012321.1 NM_002295.4 Unigene Cluster for RPSA:
Ribosomal protein SA Hs.449909 [show with all ESTs ] Unigene Representative Sequence: BC010054 10 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000301821 (uc003cjp.3 uc003cjq.3 ) ENST00000477325 ENST00000475346 ENST00000487876 ENST00000458478 ENST00000443003 ENST00000444512 ENST00000490490 ENST00000478027 ENST00000495394 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RPSA (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RPSA (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): RPSA (NM_001012321 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPSA Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RPSA
Additional cDNA sequence: AF375472.1 AF503367.1 AJ609429.1 BC005391.1 BC008867.2 BC010054.1 BC010418.2 BC013827.2 BC018867.2 BC034537.1 BC050688.1 BC053370.1 BC062714.1 BC066941.1 BC068062.1 BC070263.1 BC071693.1 BC071968.1 BC071969.1 BC071970.1 BC073863.1 BC107567.1 BT007219.1 J03799.1 L07383.1 M14199.1 NR_002324.1 NR_002325.1 S37431.1 X15005.1 X61156.1
24/141 DOTS entries (see all 141 ): DT.100860380 DT.91786361
DT.95378186 DT.102842173 DT.97864862 DT.91786018 DT.100742431 DT.91786421 DT.100742381 DT.100801725 DT.87006252 DT.100742496 DT.95378228 DT.100854981 DT.85103296 DT.100742512 DT.100837399 DT.95377954 DT.100742468 DT.100742475 DT.95378263 DT.100742502 DT.95157976 DT.100637454 24/4855 AceView cDNA sequences (see all 4855 ):
BG180002 BX462179 CB305450 BF792718 CR611940 BU175794 BM918981 BU849781 BM781990 BM788219 BF794872 BQ053162 BQ212765 BQ049394 AW250172 AW246788 BU187759 BQ941565 BQ932843 BU181336 AA977825 BU164147 BM784801 BF726735 GeneLoc Exon Structure 5/14 Alternative Splicing Database (ASD) splice patterns (SP) for RPSA (see all 14 ) About this scheme ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b SP1 :     -   -   -       -   -   -   -   -   -   -   -       -                 SP2 :     -   -   -       -   -   -   -     -   -   -       -                 SP3 :               -   -   -   -       -   -       -                 SP4 :               -   -   -   -     -   -   -       -                 SP5 :     -   -   -       -   -   -   -     -   -   -                      
ECgene alternative splicing isoforms for RPSA
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Expression for RPSA gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section RPSA expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GAAAAATGGT
About this image RPSA expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category Endoderm-like cells (Generation of hepato... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See RPSA Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for RPSA SOURCE GeneReport for Unigene cluster: Hs.449909 SABiosciences Expression via Pathway-Focused PCR Array including RPSA : Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for RPSABrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat RPSA QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat RPSA QIAGEN QuantiFast Probe-based Assays in human , mouse , rat RPSA In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPSA
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Orthologsfor RPSA gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for RPSA gene from 8/33 species (see all 33 ) About this table
ENSEMBL Gene Tree for RPSA (if available)TreeFam Gene Tree for RPSA (if available)
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Paralogsfor RPSA gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for RPSA gene RPSAP58 2 2 SIMAP similar genes for RPSA using alignment to 3 protein entries: RSSA_HUMAN (see all proteins ):LAMR1P15 RPSAP58
RPSA for paralogs About GeneDecksing 5/54 Pseudogenes.org Pseudogenes for RPSA (see all 54 )PGOHUM00000238358 PGOHUM00000251263 PGOHUM00000238843 PGOHUM00000250419 PGOHUM00000251001
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genomic Variantsfor RPSA gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 3 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for RPSA (39448180 - 39454033 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for RPSA: --
SABiosciences Cancer Mutation PCR Assays
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Disorders
/ Diseasesfor RPSA gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
RPSA for disorders About GeneDecksing OMIM gene information: 150370 OMIM disorders : 604400 20/55 diseases for RPSA (see all 55 ): About MalaCards colon carcinoma arrhythmogenic right ventricular dysplasia carcinoma arrhythmogenic right ventricular dysplasia 5 bovine spongiform encephalopathy venezuelan equine encephalitis lung cancer diffuse large b-cell lymphoma west nile virus b-cell lymphomas bile duct carcinoma cervical intraepithelial neoplasia gastrointestinal stromal tumor chronic wasting disease prion disease laryngeal squamous cell carcinoma adenoid cystic carcinoma lymphoblastic leukemia squamous cell carcinoma acute lymphoblastic leukemia 2 diseases from the University of Copenhagen DISEASES database for RPSA :Scrapie Bovine spongiform encephalopathy 10/21 Novoseek disease relationships for RPSA gene (see all 21 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
metastasis
42.9
23
8869283 (2), 19182490 (2), 10066078 (2), 15563845 (1) (see all 17 )
aggressiveness
42.4
6
15947111 (3), 11888899 (1), 16481804 (1), 19182490 (1)
cancer
33
25
8655633 (3), 7654437 (2), 19367120 (2), 8911124 (1) (see all 20 )
tumors
31.1
62
9182980 (5), 15947111 (4), 11888899 (3), 12875970 (3) (see all 26 )
ovarian carcinoma
27.2
9
8911124 (4), 10537344 (4), 11562388 (1)
carcinoma
27
25
8869283 (3), 9155714 (3), 10372715 (3), 9227340 (3) (see all 11 )
acute leukemia
16.1
1
16146788 (1)
colorectal carcinoma
16.1
7
8869283 (2), 11299735 (2)
breast carcinoma
15.7
5
10023712 (3), 10697509 (2)
prion diseases
12.6
1
10878555 (1)
Export disorders for RPSA gene to outside databases
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Publicationsfor RPSA gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for RPSA gene, integrated from 9 sources (see all 210 ): (articles sorted by number of sources associating them with RPSA) Utopia : connect your pdf to the dynamic world of online information
Isolation from a multigene family of the active human gene of the metastasis-associated multifunctional protein 37LRP/p40 at chromosome 3p21.3. (PubMed id 8760291) 1 , 2 , 3, 9 Jackers P.... Castronovo V. (1996) Cloning of 67-kDa laminin receptor cDNA and gene expression in normal and malignant cell lines of the human lung. (PubMed id 1534510) 1 , 2 , 3 Satoh K.... Motomiya M. (1992) 67-kDa laminin receptor promotes internalization of cytotoxic necrotizing factor 1-expressing Escherichia coli K1 into human brain microvascular endothelial cells. (PubMed id 15516338) 1 , 2 , 9 Kim K.J....Kim K.S. (2005) The protein phosphatase-1 targeting subunit TIMAP reg ulates LAMR1 phosphorylation. (PubMed id 16263087) 1 , 2 Kim K....Ballermann B.J. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Ribosome-associated protein LBP/p40 binds to S21 protein of 40S ribosome: analysis using a yeast two-hybrid system. (PubMed id 10079194) 1 , 2 Sato M.... Kaneda Y. (1999) A map of 75 human ribosomal protein genes. (PubMed id 9582194) 1 , 2 Kenmochi N.... Page D.C. (1998) Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699) 1 , 2 Vladimirov S.N.... Otto A. (1996) The gene for human E2 small nucleolar RNA resides in an intron of a laminin-binding protein gene. (PubMed id 8586453) 1 , 2 Selvamurugan N. and Eliceiri G.L. (1995) Characteristics of a multicopy gene family predominantly consisting of processed pseudogenes. (PubMed id 2543954) 1 , 2 van den Ouweland A.M.W.... van de Ven W.J.M. (1989)
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
External Searches for RPSA gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genome Databases showing RPSA gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Other Databases showing RPSA gene
(According to HUGE )
About This Section --
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Specialized Databases showing RPSA gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
About This Section Patent Information for RPSA gene: Search GeneIP for patents involving RPSA GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Productsfor RPSA gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for RPSA OriGene shRNA RFP for RPSA OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for RPSA OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for RPSA OriGene Protein Over-expression Lysate for RPSA Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for RPSA OriGene 3'-UTR Clone for RPSA OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RPSA OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RPSA Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for RPSA OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for RPSA OriGene Custom Protein Services for RPSA OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RPSA Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPSA QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat RPSA QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat RPSA QIAGEN QuantiFast Probe-based Assays in human , mouse , rat RPSA QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat RPSA
Search Tocris compounds for RPSA
RPSA Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPSA
ThermoFisher Antibodies for RPSA
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RPSA
Jump to Section...
Aliases for RPSA
Databases for RPSA
Disorders / Diseases for RPSA
Domains / Families for RPSA
Drugs / Compounds for RPSA
Expression for RPSA
Function for RPSA
Genomic Views for RPSA
Intellectual Property for RPSA
Orthologs for RPSA
Paralogs for RPSA
Pathways / Interactions for RPSA
Products for RPSA
Proteins for RPSA
Publications for RPSA
Search Box for RPSA
Summaries for RPSA
Transcripts for RPSA
Variants for RPSA
TOP
BOTTOM