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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPSA Gene

protein-coding   GIFtS: 62
GCID: GC03P039448

Ribosomal Protein SA

(Previous names: laminin receptor 1 (67kD, ribosomal protein SA))
(Previous symbol: LAMR1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ribosomal Protein SA1 2     LRP/LR2 3
LAMR11 2 3 5     NEM/1CHD42 3
LAMBR2 3 5     37 KDa Laminin Receptor2
Laminin Receptor 1 (67kD, Ribosomal Protein SA)1 2     40S Ribosomal Protein SA2
Colon Carcinoma Laminin-Binding Protein2 3     LBP2
Laminin-Binding Protein Precursor P402 3     LRP2
Multidrug Resistance-Associated Protein MGr1-Ag2 3     SA2
37/67 KDa Laminin Receptor2 3     lamR2
37LRP2 3     p402
67 KDa Laminin Receptor2 3     37 KDa Laminin Receptor Precursor3
67LR2 3     LamR3
LBP/p402 3     Laminin Receptor 13

External Ids:    HGNC: 65021   Entrez Gene: 39212   Ensembl: ENSG000001680287   OMIM: 1503705   UniProtKB: P088653   

Export aliases for RPSA gene to outside databases

Previous GC identifer: GC03P039424


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RPSA Gene:
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement
membranes. They have been implicated in a wide variety of biological processes including cell adhesion,
differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are
mediated through interactions with cell surface receptors. These receptors include members of the integrin
family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family,
laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor
precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly
conserved through evolution, suggesting a key biological function. It has been observed that the level of the
laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal
counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their
invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes
thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the
same protein have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for RPSA Gene: 
RPSA (ribosomal protein SA) is a protein-coding gene. Diseases associated with RPSA include arrhythmogenic right ventricular dysplasia 5, and chronic wasting disease, and among its related super-pathways are Eukaryotic Translation Initiation and Formation of the ternary complex, and subsequently, the 43S complex. GO annotations related to this gene include structural constituent of ribosome and ribosome binding. An important paralog of this gene is RPSAP58.

UniProtKB/Swiss-Prot: RSSA_HUMAN, P08865
Function: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of
the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also
functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in
the consequent activation of signaling transduction pathways. May play a role in cell fate determination and
tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. Also acts as a receptor for several other
ligands, including the pathogenic prion protein, viruses, and bacteria

Gene Wiki entry for RPSA (Ribosomal protein SA) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPSA gene promoter:
         AhR   C/EBPbeta   CBF-B   CBF(2)   CBF-C   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPSA promoter sequence
   Search SABiosciences Chromatin IP Primers for RPSA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPSA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.2   Ensembl cytogenetic band:  3p22.1   HGNC cytogenetic band: 3p21.3

RPSA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPSA gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P039448:  view genomic region     (about GC identifiers)

Start:
39,448,180 bp from pter      End:
39,454,033 bp from pter
Size:
5,854 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RSSA_HUMAN, P08865 (See protein sequence)
Recommended Name: 40S ribosomal protein SA  
Size: 295 amino acids; 32854 Da
Subunit: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist
of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule
of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).
Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK (By
similarity). Interacts with PRNP. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin
repeat). Interacts with PPP1CA only in the presence of PPP1R16B
Subcellular location: Cell membrane. Cytoplasm. Nucleus (By similarity). Note=67LR is found at the surface of the
plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found
at the cell surface, in the cytoplasm and in the nucleus (By similarity). Co-localizes with PPP1R16B in the cell
membrane
Miscellaneous: This protein appears to have acquired a second function as a laminin receptor specifically in the
vertebrate lineage
Miscellaneous: It is thought that in vertebrates 37/67 kDa laminin receptor acquired a dual function during
evolution. It developed from the ribosomal protein SA, playing an essential role in the protein biosynthesis
lacking any laminin binding activity, to a cell surface receptor with laminin binding activity
2 PDB 3D structures from and Proteopedia for RPSA:
3BCH (3D)        3J3A (3D)    
Secondary accessions: P11085 P12030 Q16471 Q6IPD1 Q6IPD2 Q6NSD1 Q6NXQ8 Q86VC0

Explore the universe of human proteins at neXtProt for RPSA: NX_P08865

Explore proteomics data for RPSA at MOPED 

Post-translational modifications:

  • UniProtKB: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor
    (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane
    association
  • UniProtKB: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter
    cell-extracellular matrix interactions (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P08865

  • RPSA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RPSA Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001012321.1  NP_002286.2  

    ENSEMBL proteins: 
     ENSP00000346067   ENSP00000410848   ENSP00000389351   ENSP00000396716  
    Reactome Protein details: P08865
    Human Recombinant Protein Products for RPSA: 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus TAS16130169
    GO:0005737cytoplasm TAS16130169
    GO:0005829cytosol TAS--
    GO:0005840ribosome ----

    RPSA for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR018130 Ribosomal_S2_CS
     IPR027504 40S_ribosomal_SA
     IPR001865 Ribosomal_S2
     IPR023591 Ribosomal_S2_flav_dom
     IPR027498 Ribosomal_S2_euk

    Graphical View of Domain Structure for InterPro Entry P08865

    ProtoNet protein and cluster: P08865

    1 Blocks protein domain: IPB001865 Ribosomal protein S2

    UniProtKB/Swiss-Prot: RSSA_HUMAN, P08865
    Similarity: Belongs to the ribosomal protein S2P family


    RPSA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RSSA_HUMAN, P08865
    Function: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of
    the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also
    functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in
    the consequent activation of signaling transduction pathways. May play a role in cell fate determination and
    tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. Also acts as a receptor for several other
    ligands, including the pathogenic prion protein, viruses, and bacteria

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome IBA--
    GO:0005055laminin receptor activity IEA--
    GO:0005515protein binding IPI16263087
    GO:0043022ribosome binding IPI10079194
    GO:0043236laminin binding IEA--
         
    RPSA for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for RPSA:
     Decreased G3BP1 protein expres  Decreased viability  Decreased viability of wild-ty 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rpsa):
     cardiovascular system  craniofacial  endocrine/exocrine gland  growth/size  hematopoietic system 
     mortality/aging 

    RPSA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rpsatm1Ells for RPSA

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RPSA 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RPSA

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RPSA About   (see all 7)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Viral mRNA Translation
    Influenza Life Cycle0.95
    3' -UTR-mediated translational regulation0.93
    Influenza Infection0.95
    L13a-mediated translational silencing of Ceruloplasmin expression0.93
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Formation of a pool of free 40S subunits0.90
    Eukaryotic Translation Termination0.94
    Nonsense-Mediated Decay0.84
    2Translation initiation complex formation
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.95
    Formation of the ternary complex, and subsequently, the 43S complex0.87
    Ribosomal scanning and start codon recognition0.95
    Translation initiation complex formation0.87
    3Metabolism of mRNA
    Metabolism of mRNA0.92
    Metabolism of RNA0.92
    4Generic Transcription Pathway
    Gene Expression0.47
    5Asparagine N-linked glycosylation
    Metabolism of proteins0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPSA
        CFTR translational fidelity (class I mutations)

    2 BioSystems Pathways for RPSA
        Alpha6-Beta4 Integrin Signaling Pathway
    Cytoplasmic Ribosomal Proteins

    5/27        Reactome Pathways for RPSA (see all 27)
        Formation of the ternary complex, and subsequently, the 43S complex
    Nonsense Mediated Decay Independent of the Exon Junction Complex
    Nonsense-Mediated Decay
    Translation
    SRP-dependent cotranslational protein targeting to membrane


    1         Kegg Pathway  (Kegg details for RPSA):
        Ribosome


    RPSA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RPSA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/230 Interacting proteins for RPSA (P088652, 3 ENSP000003460674) via UniProtKB, MINT, STRING, and/or I2D (see all 230)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000028ribosomal small subunit assembly IBA--
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA--
    GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA--
    GO:0006407rRNA export from nucleus IBA--

    RPSA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RPSA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for RPSA (RSSA)

    10 Novoseek inferred chemical compound relationships for RPSA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    egcg 72.9 47 18079119 (6), 15946647 (4), 19176763 (4), 18423375 (4) (see all 14)
    matrigel 40.4 2 11400912 (1), 19182490 (1)
    etoposide 27.4 1 19309222 (1)
    vincristine 17.5 2 12894554 (1)
    lipid 0 2 16140266 (2)
    steroid 0 1 1399148 (1)
    progesterone 0 2 14663356 (1), 10697509 (1)
    estrogen 0 6 8472397 (2), 10023712 (2), 14663356 (1), 10697509 (1)
    lactate 0 2 10999723 (1), 10499614 (1)
    cysteine 0 1 14595126 (1)

    Search CenterWatch for drugs/clinical trials and news about RPSA / RSSA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RPSA gene (2 alternative transcripts): 
    NM_001012321.1  NM_002295.4  

    Unigene Cluster for RPSA:

    Ribosomal protein SA
    Hs.449909  [show with all ESTs]
    Unigene Representative Sequence: BC010054
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000301821(uc003cjp.3 uc003cjq.3) ENST00000477325 ENST00000475346
    ENST00000487876 ENST00000458478 ENST00000443003 ENST00000444512 ENST00000490490
    ENST00000478027 ENST00000495394
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AF503367.1 BC005391.1 BC008867.2 BC010054.1 BC010418.2 BC013827.2 BC018867.2 BC034537.1 
    BC050688.1 BC053370.1 BC062714.1 BC066941.1 BC068062.1 BC070263.1 BC071693.1 BC071968.1 
    BC071969.1 BC071970.1 BC073863.1 BC107567.1 BT007219.1 J03799.1 L07383.1 M14199.1 
    NR_002324.1 S37431.1 X15005.1 X61156.1 

    24/141 DOTS entries (see all 141):

    DT.100860380  DT.91786361  DT.95378186  DT.102842173  DT.97864862  DT.91786018  DT.100742431  DT.91786421 
    DT.100742381  DT.100801725  DT.87006252  DT.100742496  DT.95378228  DT.100854981  DT.85103296  DT.100742512 
    DT.100837399  DT.95377954  DT.100742468  DT.100742475  DT.95378263  DT.100742502  DT.95157976  DT.100637454 

    24/4855 AceView cDNA sequences (see all 4855):

    BG027850 BU726607 BM463649 BM458741 BM799593 CB124884 AI083987 AW575413 
    AW328702 CR623621 BU627983 H51363 CA773607 CR595716 AI969244 BG755584 
    CR618689 BE315226 BM456541 AA207025 BG110956 BI753487 BE513356 CR626563 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for RPSA (see all 14)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b
    SP1:              -     -     -                 -     -     -     -     -     -     -     -                 -                                             
    SP2:              -     -     -                 -     -     -     -           -     -     -                 -                                             
    SP3:                                            -     -     -     -                 -     -                 -                                             
    SP4:                                            -     -     -     -           -     -     -                 -                                             
    SP5:              -     -     -                 -     -     -     -           -     -     -                                                               


    ECgene alternative splicing isoforms for RPSA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPSA expression in normal human tissues (normalized intensities)      RPSA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAAAATGGT
    RPSA Expression
    About this image


    RPSA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Blood Brain Barrier (Nervous System)
             Postnatal Endothelial Cells Blood Brain Barrier
     
     Endothelium (Cardiovascular System)
             Postnatal Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)
             Postnatal Endothelial Cells Blood Brain Barrier

    See RPSA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPSA

    SOURCE GeneReport for Unigene cluster: Hs.449909
        SABiosciences Expression via Pathway-Focused PCR Array including RPSA: 
              Tumor Metastasis in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPSA gene from 10/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rpsa1 , 5 ribosomal protein SA1, 5 88.93(n)1
    99.32(a)1
      9 (71.41 cM)5
    167851  NM_011029.41  NP_035159.31 
     1201277665 
    chicken
    (Gallus gallus)
    Aves RPSA1 ribosomal protein SA 84.07(n)
    97.97(a)
      395181  NM_001007823.1  NP_001007824.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    92(a)
    89(a)
    many ↔ many
    many ↔ many
    GL343224.1(2172674-2182114)
    4(126540318-126541058)
    African clawed frog
    (Xenopus laevis)
    Amphibia lamr1-prov2 laminin receptor 1 (ribosomal protein SA, 67 kDA) 81.4(n)    BC046271.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rpsa1 ribosomal protein SA 82.03(n)
    92.83(a)
      394027  NM_201052.1  NP_957346.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sta1 stubarista 63.41(n)
    64.66(a)
      31106  NM_057402.4  NP_476750.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rps-01 Protein RPS-0 60.78(n)
    59.77(a)
      175628  NM_065577.4  NP_497978.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPS0A(YGR214W)4 Protein component of the small (40S) ribosomal subunit, more   --   7(920575-921788) 853128  NP_011730.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons P401 40S ribosomal protein Sa-1 61.64(n)
    56.6(a)
      843569  NM_105896.3  NP_177381.1 
    rice
    (Oryza sativa)
    Liliopsida Os07g06166001 hypothetical protein 62.31(n)
    57.09(a)
      4343909  NM_001066812.1  NP_001060277.1 


    ENSEMBL Gene Tree for RPSA (if available)
    TreeFam Gene Tree for RPSA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPSA gene
    RPSAP582  
    2 SIMAP similar genes for RPSA using alignment to 3 protein entries:     RSSA_HUMAN (see all proteins):
    LAMR1P15    RPSAP58

    RPSA for paralogs           About GeneDecksing


    5/54 Pseudogenes.org Pseudogenes for RPSA (see all 54)
    PGOHUM00000238358 PGOHUM00000251263 PGOHUM00000238843 PGOHUM00000250419 PGOHUM00000251001


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/100 SNPs in RPSA are shown (see all 100)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0255224
    ----see VAR_0255222 R W mis40--------
    rs1822016381,2
    --39446237(+) GTGTAC/TGTTTC 1 -- us2k10--------
    rs98173471,2
    C,F,H--39446253(+) ctgttA/Gatttg 1 -- us2k111Minor allele frequency- G:0.09NS EA NA WA 794
    rs21335791,2
    C,F,A,H--39446288(+) TGAACA/GCTCAG 1 -- us2k118Minor allele frequency- G:0.24NS EA NA CSA WA 1422
    rs1480668731,2
    C--39446290(+) AACACT/CCAGAG 1 -- us2k11Minor allele frequency- C:0.01NS 136
    rs1869322681,2
    --39446314(+) CCCCTA/GCAAGA 1 -- us2k10--------
    rs1916709011,2
    --39446353(+) CACTCA/TGAGAT 1 -- us2k10--------
    rs1437176821,2
    C--39446372(+) ATTCA-/GCCCAGGTGTA
    AGATTTTAAAAGCT
    GCCCA
    1 -- us2k10--------
    rs1149812531,2
    --39446396(+) AAAGCA/TGCCCA 1 -- us2k10--------
    rs1401029591,2
    C--39446440(+) GGAACC/TCTGCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RPSA (39448180 - 39454033 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RPSA:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509822CNV Loss20534489

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 150370   
    OMIM disorders: 604400  
    20/52 diseases for RPSA (see all 52):    About MalaCards
    arrhythmogenic right ventricular dysplasia 5    chronic wasting disease    bovine spongiform encephalopathy    arrhythmogenic right ventricular dysplasia
    venezuelan equine encephalitis    prion disease    scrapie    lung cancer
    west nile virus    bile duct carcinoma    cervical intraepithelial neoplasia    adenoiditis
    leiomyosarcoma    adenoid cystic carcinoma    gastrointestinal stromal tumor    laryngeal squamous cell carcinoma
    acute leukemia    encephalitis    prostate adenocarcinoma    lymphoblastic leukemia

    2 diseases from the University of Copenhagen DISEASES database for RPSA:
    Scrapie     Bovine spongiform encephalopathy

    RPSA for disorders           About GeneDecksing

    10/21 Novoseek inferred disease relationships for RPSA gene (see all 21)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 42.9 23 8869283 (2), 19182490 (2), 10066078 (2), 15563845 (1) (see all 17)
    aggressiveness 42.4 6 15947111 (3), 11888899 (1), 16481804 (1), 19182490 (1)
    cancer 33 25 8655633 (3), 7654437 (2), 19367120 (2), 8911124 (1) (see all 20)
    tumors 31.1 62 9182980 (5), 15947111 (4), 11888899 (3), 12875970 (3) (see all 26)
    ovarian carcinoma 27.2 9 8911124 (4), 10537344 (4), 11562388 (1)
    carcinoma 27 25 8869283 (3), 9155714 (3), 10372715 (3), 9227340 (3) (see all 11)
    acute leukemia 16.1 1 16146788 (1)
    colorectal carcinoma 16.1 7 8869283 (2), 11299735 (2)
    breast carcinoma 15.7 5 10023712 (3), 10697509 (2)
    prion diseases 12.6 1 10878555 (1)


    Export disorders for RPSA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPSA gene, integrated from 9 sources (see all 230):
    (articles sorted by number of sources associating them with RPSA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation from a multigene family of the active human gene of the metastasis-associated multifunctional protein 37LRP/p40 at chromosome 3p21.3. (PubMed id 8760291)1, 2, 3, 9 Jackers P.... Castronovo V. (1996)
    2. Cloning of 67-kDa laminin receptor cDNA and gene expression in normal and malignant cell lines of the human lung. (PubMed id 1534510)1, 2, 3 Satoh K.... Motomiya M. (1992)
    3. 67-kDa laminin receptor promotes internalization of cytotoxic necrotizing factor 1-expressing Escherichia coli K1 into human brain microvascular endothelial cells. (PubMed id 15516338)1, 2, 9 Kim K.J....Kim K.S. (2005)
    4. The protein phosphatase-1 targeting subunit TIMAP reg ulates LAMR1 phosphorylation. (PubMed id 16263087)1, 2 Kim K....Ballermann B.J. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Ribosome-associated protein LBP/p40 binds to S21 protein of 40S ribosome: analysis using a yeast two-hybrid system. (PubMed id 10079194)1, 2 Sato M.... Kaneda Y. (1999)
    7. A map of 75 human ribosomal protein genes. (PubMed id 9582194)1, 2 Kenmochi N.... Page D.C. (1998)
    8. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699)1, 2 Vladimirov S.N.... Otto A. (1996)
    9. The gene for human E2 small nucleolar RNA resides in an intron of a laminin-binding protein gene. (PubMed id 8586453)1, 2 Selvamurugan N. and Eliceiri G.L. (1995)
    10. Characteristics of a multicopy gene family predominantly consisting of processed pseudogenes. (PubMed id 2543954)1, 2 van den Ouweland A.M.W.... van de Ven W.J.M. (1989)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3921 HGNC: 6502 AceView: LAMR1 Ensembl:ENSG00000168028 euGenes: HUgn3921
    ECgene: RPSA Kegg: 3921 H-InvDB: RPSA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPSA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RPSA Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RPSA gene:
    Search GeneIP for patents involving RPSA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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