Aliases for RPSA Gene
- Ribosomal Protein SA 2 3 5
- Laminin Receptor 1 (67kD, Ribosomal Protein SA) 2 3
- Multidrug Resistance-Associated Protein MGr1-Ag 3 4
- Colon Carcinoma Laminin-Binding Protein 3 4
- Laminin-Binding Protein Precursor P40 3 4
- 37/67 KDa Laminin Receptor 3 4
- 67 KDa Laminin Receptor 3 4
- NEM/1CHD4 3 4
- LBP/P40 3 4
- LRP/LR 3 4
- LAMR1 3 4
- 37LRP 3 4
- LAMBR 3 4
External Ids for RPSA Gene
Previous HGNC Symbols for RPSA Gene
Previous GeneCards Identifiers for RPSA Gene
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for RPSA Gene
RPSA (Ribosomal Protein SA) is a Protein Coding gene. Diseases associated with RPSA include Asplenia, Isolated Congenital and Venezuelan Equine Encephalitis. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Metabolism. GO annotations related to this gene include poly(A) RNA binding and ribosome binding.
UniProtKB/Swiss-Prot for RPSA Gene
Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA.
(Microbial infection) Acts as a receptor for the adeno-associated viruses 2,3,8 and 9, dengue virus, Sindbis virus and Venezuelan equine encephalitis virus (PubMed:1385835, PubMed:15507651, PubMed:16973587). Also acts as a receptor for pathogenic prion protein and bacteria (PubMed:9396609, PubMed:11689427, PubMed:15516338).