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Aliases for RPSA Gene

Aliases for RPSA Gene

  • Ribosomal Protein SA 2 3
  • LAMR1 3 4 6
  • LAMBR 3 4 6
  • Laminin Receptor 1 (67kD, Ribosomal Protein SA) 2 3
  • Multidrug Resistance-Associated Protein MGr1-Ag 3 4
  • Colon Carcinoma Laminin-Binding Protein 3 4
  • Laminin-Binding Protein Precursor P40 3 4
  • 37/67 KDa Laminin Receptor 3 4
  • 67 KDa Laminin Receptor 3 4
  • NEM/1CHD4 3 4
  • LBP/P40 3 4
  • LRP/LR 3 4
  • 37LRP 3 4
  • LAMR 3 4
  • ICAS 3 6
  • 67LR 3 4
  • 37 KDa Laminin Receptor Precursor 4
  • 40S Ribosomal Protein SA 3
  • 37 KDa Laminin Receptor 3
  • Laminin Receptor 1 4
  • P40 3
  • LBP 3
  • LRP 3
  • SA 3

External Ids for RPSA Gene

Previous HGNC Symbols for RPSA Gene

  • LAMR1

Previous GeneCards Identifiers for RPSA Gene

  • GC03P039424
  • GC03P039448

Summaries for RPSA Gene

Entrez Gene Summary for RPSA Gene

  • Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPSA Gene

RPSA (Ribosomal Protein SA) is a Protein Coding gene. Diseases associated with RPSA include asplenia, isolated congenital and familial isolated congenital asplenia. Among its related pathways are Disease and IL6-mediated signaling events. GO annotations related to this gene include structural constituent of ribosome and laminin binding. An important paralog of this gene is RPSAP58.

UniProtKB/Swiss-Prot for RPSA Gene

  • Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria.

Gene Wiki entry for RPSA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPSA Gene

Genomics for RPSA Gene

Regulatory Elements for RPSA Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RPSA Gene

Start:
39,406,689 bp from pter
End:
39,412,542 bp from pter
Size:
5,854 bases
Orientation:
Plus strand

Genomic View for RPSA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPSA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPSA Gene

Proteins for RPSA Gene

  • Protein details for RPSA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08865-RSSA_HUMAN
    Recommended name:
    40S ribosomal protein SA
    Protein Accession:
    P08865
    Secondary Accessions:
    • P11085
    • P12030
    • Q16471
    • Q6IPD1
    • Q6IPD2
    • Q6NSD1
    • Q6NXQ8
    • Q86VC0

    Protein attributes for RPSA Gene

    Size:
    295 amino acids
    Molecular mass:
    32854 Da
    Quaternary structure:
    • Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK (By similarity). Interacts with PRNP. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.
    Miscellaneous:
    • It is thought that in vertebrates 37/67 kDa laminin receptor acquired a dual function during evolution. It developed from the ribosomal protein SA, playing an essential role in the protein biosynthesis lacking any laminin binding activity, to a cell surface receptor with laminin binding activity
    • This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage

    Three dimensional structures from OCA and Proteopedia for RPSA Gene

neXtProt entry for RPSA Gene

Proteomics data for RPSA Gene at MOPED

Post-translational modifications for RPSA Gene

  • Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association (PubMed:9581863).
  • Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
  • Ubiquitination at Lys11, Lys40, Lys52, Lys57, Lys89, and Lys166
  • Modification sites at PhosphoSitePlus

Other Protein References for RPSA Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RPSA Gene

Domains for RPSA Gene

Suggested Antigen Peptide Sequences for RPSA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P08865

UniProtKB/Swiss-Prot:

RSSA_HUMAN :
  • P08865
Family:
  • Belongs to the ribosomal protein S2P family.
genes like me logo Genes that share domains with RPSA: view

No data available for Gene Families for RPSA Gene

Function for RPSA Gene

Molecular function for RPSA Gene

UniProtKB/Swiss-Prot Function:
Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria.

Gene Ontology (GO) - Molecular Function for RPSA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IBA --
GO:0005055 laminin receptor activity IEA --
GO:0005515 protein binding IPI 16263087
GO:0043022 ribosome binding IPI 10079194
GO:0043236 laminin binding IEA --
genes like me logo Genes that share ontologies with RPSA: view
genes like me logo Genes that share phenotypes with RPSA: view

Animal Models for RPSA Gene

MGI Knock Outs for RPSA:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPSA

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RPSA Gene

Localization for RPSA Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPSA Gene

Cell membrane. Cytoplasm. Nucleus. Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus (By similarity). Colocalizes with PPP1R16B in the cell membrane. {ECO:0000255 HAMAP-Rule:MF_03016}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPSA Gene COMPARTMENTS Subcellular localization image for RPSA gene
Compartment Confidence
cytosol 5
nucleus 5
plasma membrane 5
extracellular 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for RPSA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus TAS 16130169
GO:0005737 cytoplasm TAS 16130169
GO:0005829 cytosol TAS --
GO:0005840 ribosome --
genes like me logo Genes that share ontologies with RPSA: view

Pathways for RPSA Gene

SuperPathways for RPSA Gene

Superpath Contained pathways
1 Influenza Viral RNA Transcription and Replication
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Cytokine production by Th17 cells in CF
4 Toll-like receptor signaling pathway
5 Bacterial infections in CF airways
genes like me logo Genes that share pathways with RPSA: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for RPSA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000028 ribosomal small subunit assembly IBA --
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0000461 endonucleolytic cleavage to generate mature 3-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0006407 rRNA export from nucleus IBA --
genes like me logo Genes that share ontologies with RPSA: view

Compounds for RPSA Gene

(10) Novoseek inferred chemical compound relationships for RPSA Gene

Compound -log(P) Hits PubMed IDs
egcg 72.9 36
matrigel 40.4 2
etoposide 27.4 1
vincristine 17.5 1
lipid 0 2
genes like me logo Genes that share compounds with RPSA: view

Transcripts for RPSA Gene

Unigene Clusters for RPSA Gene

Ribosomal protein SA:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPSA

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPSA Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - -
SP9:
SP10: - - - - - - -
SP11: - - -
SP12: - -
SP13: - - -
SP14:

Relevant External Links for RPSA Gene

GeneLoc Exon Structure for
RPSA
ECgene alternative splicing isoforms for
RPSA

Expression for RPSA Gene

mRNA expression in normal human tissues for RPSA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for RPSA Gene

This gene is overexpressed in Bone marrow stromal cell (14.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RPSA Gene

SOURCE GeneReport for Unigene cluster for RPSA Gene Hs.449909

genes like me logo Genes that share expressions with RPSA: view

Expression partners for RPSA Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPSA Gene

Orthologs for RPSA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPSA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPSA 35
  • 90.62 (n)
  • 98.31 (a)
RPSA 36
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RPSA 35
  • 93.67 (n)
  • 99.32 (a)
-- 36
  • 73 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rpsa 35
  • 88.93 (n)
  • 99.32 (a)
Rpsa 16
Rpsa-ps10 36
  • 99 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC740423 35
  • 99.55 (n)
  • 100 (a)
RPSA 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpsa 35
  • 88.47 (n)
  • 98.98 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 99 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 91 (a)
OneToMany
chicken
(Gallus gallus)
Aves RPSA 35
  • 84.07 (n)
  • 97.97 (a)
RPSA 36
  • 98 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 88 (a)
ManyToMany
-- 36
  • 92 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75768 35
rpsa 35
  • 81.91 (n)
  • 93.86 (a)
African clawed frog
(Xenopus laevis)
Amphibia lamr1-prov 35
zebrafish
(Danio rerio)
Actinopterygii rpsa 35
  • 82.03 (n)
  • 92.83 (a)
rpsa 36
  • 88 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta RSSA_ANOGA 35
  • 62.58 (n)
  • 63.18 (a)
fruit fly
(Drosophila melanogaster)
Insecta sta 35
  • 67.88 (n)
  • 73.52 (a)
sta 36
  • 53 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rps-0 35
  • 61.03 (n)
  • 59.77 (a)
rps-0 36
  • 56 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL140C 35
  • 60.92 (n)
  • 58.82 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E16171g 35
  • 61.74 (n)
  • 59.49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS0A 35
  • 59.63 (n)
  • 59.92 (a)
RPS0A 36
  • 55 (a)
ManyToMany
RPS0B 36
  • 56 (a)
ManyToMany
RPS0A 38
thale cress
(Arabidopsis thaliana)
eudicotyledons P40 35
  • 62.71 (n)
  • 58.24 (a)
rice
(Oryza sativa)
Liliopsida Os07g0616600 35
  • 62.31 (n)
  • 57.09 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03393 35
  • 58.52 (n)
  • 56.3 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps002 35
  • 63.41 (n)
  • 63.41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 65 (a)
ManyToMany
CSA.5233 36
  • 67 (a)
ManyToMany
Species with no ortholog for RPSA:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPSA Gene

ENSEMBL:
Gene Tree for RPSA (if available)
TreeFam:
Gene Tree for RPSA (if available)

Paralogs for RPSA Gene

Paralogs for RPSA Gene

Selected SIMAP similar genes for RPSA Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RPSA: view

Variants for RPSA Gene

Sequence variations from dbSNP and Humsavar for RPSA Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs2723 -- 39,412,119(+) TTATT(C/T)TAACT intron-variant
rs2724 -- 39,412,284(+) TGGAG(C/T)GCTCA reference, synonymous-codon
rs2725 -- 39,412,285(+) GGAGC(A/G)CTCAG missense, reference
rs2133579 -- 39,404,797(+) TGAAC(A/G)CTCAG upstream-variant-2KB
rs2173603 -- 39,404,979(+) GCAAT(C/T)CCAAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPSA Gene

Variant ID Type Subtype PubMed ID
nsv509822 CNV Loss 20534489

Relevant External Links for RPSA Gene

HapMap Linkage Disequilibrium report
RPSA
Human Gene Mutation Database (HGMD)
RPSA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPSA Gene

Disorders for RPSA Gene

(1) OMIM Diseases for RPSA Gene (150370)

(2) University of Copenhagen DISEASES for RPSA Gene

(21) Novoseek inferred disease relationships for RPSA Gene

Disease -log(P) Hits PubMed IDs
metastasis 42.9 20
aggressiveness 42.4 6
cancer 33 24
tumors 31.1 43
ovarian carcinoma 27.2 9
genes like me logo Genes that share disorders with RPSA: view

No data available for UniProtKB/Swiss-Prot , Genatlas and External Links for RPSA Gene

Publications for RPSA Gene

  1. Isolation from a multigene family of the active human gene of the metastasis-associated multifunctional protein 37LRP/p40 at chromosome 3p21.3. (PMID: 8760291) Jackers P. … Castronovo V. (Oncogene 1996) 2 3 4 23
  2. 67-kDa laminin receptor promotes internalization of cytotoxic necrotizing factor 1-expressing Escherichia coli K1 into human brain microvascular endothelial cells. (PMID: 15516338) Kim K.J. … Kim K.S. (J. Biol. Chem. 2005) 3 4 23
  3. Cloning of 67-kDa laminin receptor cDNA and gene expression in normal and malignant cell lines of the human lung. (PMID: 1534510) Satoh K. … Motomiya M. (Cancer Lett. 1992) 2 3 4
  4. Altered levels of laminin receptor mRNA in various human carcinoma cells that have different abilities to bind laminin. (PMID: 2429301) Wewer U.M. … Sobel M.E. (Proc. Natl. Acad. Sci. U.S.A. 1986) 3 4
  5. Characteristics of a multicopy gene family predominantly consisting of processed pseudogenes. (PMID: 2543954) van den Ouweland A.M.W. … van de Ven W.J.M. (Nucleic Acids Res. 1989) 3 4

Products for RPSA Gene

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