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Aliases for RPSA Gene

Aliases for RPSA Gene

  • Ribosomal Protein SA 2 3 5
  • Laminin Receptor 1 (67kD, Ribosomal Protein SA) 2 3
  • Multidrug Resistance-Associated Protein MGr1-Ag 3 4
  • Colon Carcinoma Laminin-Binding Protein 3 4
  • Laminin-Binding Protein Precursor P40 3 4
  • Small Ribosomal Subunit Protein US2 3 4
  • 37/67 KDa Laminin Receptor 3 4
  • 67 KDa Laminin Receptor 3 4
  • NEM/1CHD4 3 4
  • LBP/P40 3 4
  • LRP/LR 3 4
  • LAMR1 3 4
  • 37LRP 3 4
  • LAMBR 3 4
  • LamR 3 4
  • 67LR 3 4
  • 37 KDa Laminin Receptor Precursor 4
  • 40S Ribosomal Protein SA 3
  • 37 KDa Laminin Receptor 3
  • Laminin Receptor 1 4
  • ICAS 3
  • P40 3
  • LBP 3
  • LRP 3
  • SA 3

External Ids for RPSA Gene

Previous HGNC Symbols for RPSA Gene

  • LAMR1

Previous GeneCards Identifiers for RPSA Gene

  • GC03P039424
  • GC03P039448

Summaries for RPSA Gene

Entrez Gene Summary for RPSA Gene

  • Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPSA Gene

RPSA (Ribosomal Protein SA) is a Protein Coding gene. Diseases associated with RPSA include Asplenia, Isolated Congenital and Venezuelan Equine Encephalitis. Among its related pathways are Viral mRNA Translation and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. GO annotations related to this gene include poly(A) RNA binding and ribosome binding.

UniProtKB/Swiss-Prot for RPSA Gene

  • Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA.

  • (Microbial infection) Acts as a receptor for the adeno-associated viruses 2,3,8 and 9, dengue virus, Sindbis virus and Venezuelan equine encephalitis virus (PubMed:1385835, PubMed:15507651, PubMed:16973587). Also acts as a receptor for pathogenic prion protein and bacteria (PubMed:9396609, PubMed:11689427, PubMed:15516338).

Gene Wiki entry for RPSA Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPSA Gene

Genomics for RPSA Gene

Regulatory Elements for RPSA Gene

Enhancers for RPSA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G039403 1.2 ENCODE 57.7 +0.4 368 6.2 CREB3L1 AGO1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 NFYC MEF2D SSRP1 RPSA SNORA62 GC03P039409
GH03G039382 1.4 ENCODE dbSUPER 42 -22.9 -22907 2.7 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 RPSA SNORA62 GORASP1 XIRP1 SLC25A38 GC03M039393
GH03G039387 1.1 Ensembl ENCODE 40.7 -17.9 -17939 2.5 HDAC1 HDGF TBP PKNOX1 CBX3 NFIB TBL1XR1 WRNIP1 TCF12 RELB RPSA SLC25A38 GC03M039393
GH03G039361 1.6 FANTOM5 Ensembl ENCODE dbSUPER 23.1 -44.7 -44683 1.6 BCOR MAX RELA GATA3 ZNF316 POLR2A EGR1 EED TRIM24 NR2F6 RPSA HNRNPA1P21 CCR8 SNORA6 CX3CR1 XIRP1 SLC25A38 WDR48 EEF1A1P24 GC03P039372
GH03G039413 0.8 ENCODE 33.3 +7.7 7680 1.1 HNRNPUL1 PKNOX1 CBX3 AGO1 CHD7 RELA CCNT2 POLR2A KDM5B BCLAF1 RPSA GC03P039422 LOC105377038
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPSA on UCSC Golden Path with GeneCards custom track

Promoters for RPSA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000151095 311 2001 PKNOX1 FOXA2 CREB3L1 ARNT AGO1 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for RPSA Gene

Chromosome:
3
Start:
39,406,689 bp from pter
End:
39,412,542 bp from pter
Size:
5,854 bases
Orientation:
Plus strand

Genomic View for RPSA Gene

Genes around RPSA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPSA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPSA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPSA Gene

Proteins for RPSA Gene

  • Protein details for RPSA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08865-RSSA_HUMAN
    Recommended name:
    40S ribosomal protein SA
    Protein Accession:
    P08865
    Secondary Accessions:
    • P11085
    • P12030
    • Q16471
    • Q6IPD1
    • Q6IPD2
    • Q6NSD1
    • Q6NXQ8
    • Q86VC0

    Protein attributes for RPSA Gene

    Size:
    295 amino acids
    Molecular mass:
    32854 Da
    Quaternary structure:
    • Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK (By similarity). The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.
    • (Microbial infection) 67LR interacts with capsid protein of Adeno-associated virus 2,3,8 and 9.
    • (Microbial infection) 67LR interacts with envelope protein of dengue virus.
    • (Microbial infection) 6s7LR interacts with E2 glycoprotein of Sindbis and Venezuelan equine encephalitis virus (PubMed:8764073, PubMed:1385835).
    Miscellaneous:
    • It is thought that in vertebrates 37/67 kDa laminin receptor acquired a dual function during evolution. It developed from the ribosomal protein SA, playing an essential role in the protein biosynthesis lacking any laminin binding activity, to a cell surface receptor with laminin binding activity.
    • This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

    Three dimensional structures from OCA and Proteopedia for RPSA Gene

neXtProt entry for RPSA Gene

Post-translational modifications for RPSA Gene

  • Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association (PubMed:9581863).
  • Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
  • Ubiquitination at isoforms=40, isoforms=52, isoforms=57, Lys89, and Lys166
  • Modification sites at PhosphoSitePlus

Other Protein References for RPSA Gene

No data available for DME Specific Peptides for RPSA Gene

Domains & Families for RPSA Gene

Suggested Antigen Peptide Sequences for RPSA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P08865

UniProtKB/Swiss-Prot:

RSSA_HUMAN :
  • Belongs to the universal ribosomal protein uS2 family.
Family:
  • Belongs to the universal ribosomal protein uS2 family.
genes like me logo Genes that share domains with RPSA: view

No data available for Gene Families for RPSA Gene

Function for RPSA Gene

Molecular function for RPSA Gene

UniProtKB/Swiss-Prot Function:
Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for the adeno-associated viruses 2,3,8 and 9, dengue virus, Sindbis virus and Venezuelan equine encephalitis virus (PubMed:1385835, PubMed:15507651, PubMed:16973587). Also acts as a receptor for pathogenic prion protein and bacteria (PubMed:9396609, PubMed:11689427, PubMed:15516338).

Gene Ontology (GO) - Molecular Function for RPSA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0003723 RNA binding IDA 22681889
GO:0003735 structural constituent of ribosome IBA,IEA --
GO:0005055 laminin receptor activity IEA --
GO:0005515 protein binding IPI 16263087
genes like me logo Genes that share ontologies with RPSA: view
genes like me logo Genes that share phenotypes with RPSA: view

Human Phenotype Ontology for RPSA Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for RPSA Gene

MGI Knock Outs for RPSA:

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for RPSA Gene

Localization for RPSA Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPSA Gene

Cell membrane. Cytoplasm. Nucleus. Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus (By similarity). Colocalizes with PPP1R16B in the cell membrane. {ECO:0000255 HAMAP-Rule:MF_03016}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPSA gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
cytosol 5
cytoskeleton 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPSA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005604 basement membrane IEA --
GO:0005622 intracellular IEA --
GO:0005634 nucleus TAS,IEA 16130169
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm TAS,IEA 16130169
genes like me logo Genes that share ontologies with RPSA: view

Pathways & Interactions for RPSA Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
.56
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing in the nucleus and cytosol
5 HIV Life Cycle
.45
genes like me logo Genes that share pathways with RPSA: view

Gene Ontology (GO) - Biological Process for RPSA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000028 ribosomal small subunit assembly IBA --
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0000461 endonucleolytic cleavage to generate mature 3-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0006364 rRNA processing TAS --
genes like me logo Genes that share ontologies with RPSA: view

No data available for SIGNOR curated interactions for RPSA Gene

Drugs & Compounds for RPSA Gene

(6) Drugs for RPSA Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
PCK3145 Investigational Pharma Target 0

(5) Additional Compounds for RPSA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RPSA: view

Transcripts for RPSA Gene

Unigene Clusters for RPSA Gene

Ribosomal protein SA:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPSA Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - -
SP9:
SP10: - - - - - - -
SP11: - - -
SP12: - -
SP13: - - -
SP14:

Relevant External Links for RPSA Gene

GeneLoc Exon Structure for
RPSA
ECgene alternative splicing isoforms for
RPSA

Expression for RPSA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPSA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPSA Gene

This gene is overexpressed in Bone marrow stromal cell (14.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RPSA Gene



Protein tissue co-expression partners for RPSA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPSA Gene:

RPSA

SOURCE GeneReport for Unigene cluster for RPSA Gene:

Hs.449909

Evidence on tissue expression from TISSUES for RPSA Gene

  • Lung(5)
  • Nervous system(5)
  • Blood(4.9)
  • Eye(4.9)
  • Liver(4.9)
  • Intestine(4.8)
  • Pancreas(4.8)
  • Skin(4.8)
  • Bone(4.7)
  • Kidney(4.5)
  • Muscle(4.5)
  • Stomach(4.4)
  • Heart(3.3)
  • Lymph node(2.7)
  • Thyroid gland(2.3)
  • Bone marrow(2.1)
  • Spleen(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for RPSA Gene

Germ Layers:
  • mesoderm
Systems:
  • immune
  • lymphatic
Organs:
Abdomen:
  • spleen
genes like me logo Genes that share expression patterns with RPSA: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPSA Gene

Orthologs for RPSA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPSA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPSA 35
  • 100 (a)
OneToOne
LOC740423 34
  • 99.55 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 99 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rpsa-ps10 35
  • 99 (a)
ManyToMany
Rpsa 34 16
  • 88.93 (n)
dog
(Canis familiaris)
Mammalia RPSA 34
  • 93.67 (n)
-- 35
  • 73 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 91 (a)
OneToMany
cow
(Bos Taurus)
Mammalia RPSA 34 35
  • 90.62 (n)
rat
(Rattus norvegicus)
Mammalia Rpsa 34
  • 88.47 (n)
chicken
(Gallus gallus)
Aves RPSA 34 35
  • 84.07 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 92 (a)
ManyToMany
-- 35
  • 88 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rpsa 34
  • 81.91 (n)
MGC75768 34
African clawed frog
(Xenopus laevis)
Amphibia lamr1-prov 34
zebrafish
(Danio rerio)
Actinopterygii rpsa 34 35
  • 82.03 (n)
fruit fly
(Drosophila melanogaster)
Insecta sta 34 35
  • 67.88 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta RSSA_ANOGA 34
  • 62.58 (n)
worm
(Caenorhabditis elegans)
Secernentea rps-0 34 35
  • 61.03 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E16171g 34
  • 61.74 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL140C 34
  • 60.92 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS0A 34 35 37
  • 59.63 (n)
RPS0B 35
  • 56 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons P40 34
  • 62.71 (n)
rice
(Oryza sativa)
Liliopsida Os07g0616600 34
  • 62.31 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5233 35
  • 67 (a)
ManyToMany
-- 35
  • 65 (a)
ManyToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps002 34
  • 63.41 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03393 34
  • 58.52 (n)
Species where no ortholog for RPSA was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPSA Gene

ENSEMBL:
Gene Tree for RPSA (if available)
TreeFam:
Gene Tree for RPSA (if available)

Paralogs for RPSA Gene

(2) SIMAP similar genes for RPSA Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RPSA: view

No data available for Paralogs for RPSA Gene

Variants for RPSA Gene

Sequence variations from dbSNP and Humsavar for RPSA Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs397514760 Pathogenic, Asplenia, isolated congenital (ICAS) [MIM:271400], Asplenia, isolated congenital (ICAS) [MIM:271400] 39,411,688(+) TGGCT(C/G/T)GGGAA downstream-variant-500B, reference, missense
rs397514761 Pathogenic, Asplenia, isolated congenital (ICAS) [MIM:271400] 39,411,706(+) GCATG(C/T)GTGGC downstream-variant-500B, reference, missense
rs397514762 Pathogenic, Asplenia, isolated congenital (ICAS) [MIM:271400] 39,408,633(+) GAGGA(A/C)CTGGG downstream-variant-500B, reference, missense
rs397514763 Pathogenic, Asplenia, isolated congenital (ICAS) [MIM:271400] 39,408,644(+) AGAAG(C/T)TTCTG downstream-variant-500B, reference, missense
rs397514759 Pathogenic 39,407,678(+) TCCTG(C/T)AAATG upstream-variant-2KB, reference, stop-gained

Structural Variations from Database of Genomic Variants (DGV) for RPSA Gene

Variant ID Type Subtype PubMed ID
nsv509822 OTHER sequence alteration 20534489
nsv963310 CNV duplication 23825009

Variation tolerance for RPSA Gene

Residual Variation Intolerance Score: 34.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPSA Gene

Human Gene Mutation Database (HGMD)
RPSA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPSA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPSA Gene

Disorders for RPSA Gene

MalaCards: The human disease database

(13) MalaCards diseases for RPSA Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
asplenia, isolated congenital
  • familial isolated congenital asplenia
venezuelan equine encephalitis
  • venezuelan equine fever
encephalitis
cerebral arterial disease
  • cerebral arterial diseases
tolosa-hunt syndrome
  • tolosa hunt syndrome
- elite association - COSMIC cancer census association via MalaCards
Search RPSA in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

RSSA_HUMAN
  • Asplenia, isolated congenital (ICAS) [MIM:271400]: A rare primary immunodeficiency and life-threatening condition, often presenting with pneumococcal sepsis. Most affected individuals die of severe bacterial infections in early childhood. Isolated asplenia is distinct from asplenia associated with other complex visceral defects, notably heterotaxy syndromes such as Ivemark syndrome. {ECO:0000269 PubMed:23579497}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for RPSA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPSA
genes like me logo Genes that share disorders with RPSA: view

No data available for Genatlas for RPSA Gene

Publications for RPSA Gene

  1. Isolation from a multigene family of the active human gene of the metastasis-associated multifunctional protein 37LRP/p40 at chromosome 3p21.3. (PMID: 8760291) Jackers P. … Castronovo V. (Oncogene 1996) 2 3 4 22 64
  2. 67-kDa laminin receptor promotes internalization of cytotoxic necrotizing factor 1-expressing Escherichia coli K1 into human brain microvascular endothelial cells. (PMID: 15516338) Kim K.J. … Kim K.S. (J. Biol. Chem. 2005) 3 4 22 64
  3. Cloning of 67-kDa laminin receptor cDNA and gene expression in normal and malignant cell lines of the human lung. (PMID: 1534510) Satoh K. … Motomiya M. (Cancer Lett. 1992) 2 3 4 64
  4. Ribosomal protein SA haploinsufficiency in humans with isolated congenital asplenia. (PMID: 23579497) Bolze A. … Casanova J.L. (Science 2013) 3 4 64
  5. Interactions of the 67 kDa laminin receptor and its precursor with laminin. (PMID: 19691449) Fatehullah A. … Timson D.J. (Biosci. Rep. 2010) 3 22 64

Products for RPSA Gene

Sources for RPSA Gene

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