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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPSA Gene

protein-coding   GIFtS: 63
GCID: GC03P039448

ribosomal protein SA

(Previous names: laminin receptor 1 (67kD, ribosomal protein SA) )
(Previous symbol: LAMR1)
 Explore 55 diseases affiliated with
RPSA via our new
 Human Malady Compendium 
Biological research products
for RPSA
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Ribosomal Protein SA1 2     67LR2 3
LAMR11 2 3 5     LBP/P401
37LRP1 2 3     LRP/LR2 3
LAMBR2 3 5     NEM/1CHD42 3
LRP1 2     37 KDa Laminin Receptor2
SA1 2     40S Ribosomal Protein SA2
Laminin Receptor 1 (67kD, Ribosomal Protein SA)1 2     67kD, Ribosomal Protein SA2
P401     LBP2
Colon Carcinoma Laminin-Binding Protein2 3     LamR3
Laminin-Binding Protein Precursor P402 3     Laminin Binding Protein2
Multidrug Resistance-Associated Protein MGr1-Ag2 3     37 KDa Laminin Receptor Precursor3
37/67 KDa Laminin Receptor2 3     LamR3
67 KDa Laminin Receptor2 3     Laminin Receptor 13

External Ids:    HGNC: 65021   Entrez Gene: 39212   Ensembl: ENSG000001680287   OMIM: 1503705   UniProtKB: P088653   

Export aliases for RPSA gene to outside databases

Previous GC identifer: GC03P039424


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RPSA:
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement
membranes. They have been implicated in a wide variety of biological processes including cell adhesion,
differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated
through interactions with cell surface receptors. These receptors include members of the integrin family, as well as
non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1.
This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40
ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution,
suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher
in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation
between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple
copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events.
Two alternatively spliced transcript variants encoding the same protein have been found for this gene. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RSSA_HUMAN, P08865
Function: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the
20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a
cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent
activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis.
Acts as a PPP1R16B-dependent substrate of PPP1CA. Also acts as a receptor for several other ligands, including the
pathogenic prion protein, viruses, and bacteria

Gene Wiki entry for RPSA (Ribosomal protein SA)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPSA gene promoter:
         AhR   C/EBPbeta   CBF-B   CBF(2)   CBF-C   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPSA promoter sequence
   Search SABiosciences Chromatin IP Primers for RPSA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPSA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.2   Ensembl cytogenetic band:  3p22.1   HGNC cytogenetic band: 3p21.3

RPSA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPSA gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P039448:  view genomic region     (about GC identifiers)

Start:
39,448,180 bp from pter      End:
39,454,033 bp from pter
Size:
5,854 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RSSA_HUMAN, P08865 (See protein sequence)
Recommended Name: 40S ribosomal protein SA  
Size: 295 amino acids; 32854 Da
Subunit: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a
small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA
(18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with
RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK (By similarity). Interacts with
PRNP. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in
the presence of PPP1R16B
Subcellular location: Cell membrane. Cytoplasm. Nucleus (By similarity). Note=67LR is found at the surface of the
plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the
cell surface, in the cytoplasm and in the nucleus (By similarity). Co-localizes with PPP1R16B in the cell membrane
Miscellaneous: This protein appears to have acquired a second function as a laminin receptor specifically in the
vertebrate lineage
Miscellaneous: It is thought that in vertebrates 37/67 kDa laminin receptor acquired a dual function during evolution.
It developed from the ribosomal protein SA, playing an essential role in the protein biosynthesis lacking any laminin
binding activity, to a cell surface receptor with laminin binding activity
1 PDB 3D structure from and Proteopedia for RPSA:
3BCH (3D)    
Secondary accessions: P11085 P12030 Q16471 Q6IPD1 Q6IPD2 Q6NSD1 Q6NXQ8 Q86VC0

Explore the universe of human proteins at neXtProt for RPSA: NX_P08865

Post-translational modifications:

  • Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to
  • the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association1
  • Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter
  • cell-extracellular matrix interactions (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P08865

  • RPSA Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001012321.1  NP_002286.2  

    ENSEMBL proteins: 
     ENSP00000346067   ENSP00000410848   ENSP00000389351   ENSP00000396716  
    Reactome Protein details: P08865
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    Uscn Proteins for RPSA

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS16130169
    GO:0005737cytoplasm TAS16130169
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA16263087
    GO:0015935small ribosomal subunit ----


    RPSA for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    RPSA for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR018130 Ribosomal_S2_CS
     IPR001865 Ribosomal_S2
     IPR023591 Ribosomal_S2_flav_dom
     IPR005707 Ribosomal_S2_euk/arc

    Graphical View of Domain Structure for InterPro Entry P08865

    ProtoNet protein and cluster: P08865

    1 Blocks protein family: IPB001865 Ribosomal protein S2

    UniProtKB/Swiss-Prot: RSSA_HUMAN, P08865
    Similarity: Belongs to the ribosomal protein S2P family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: RSSA_HUMAN, P08865
    Function: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the
    20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a
    cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent
    activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis.
    Acts as a PPP1R16B-dependent substrate of PPP1CA. Also acts as a receptor for several other ligands, including the
    pathogenic prion protein, viruses, and bacteria

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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome IBA--
    GO:0004872receptor activity ----
    GO:0005515protein binding IPI16263087
    GO:0043022ribosome binding IPI10079194


    RPSA for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for RPSA:
     Decreased G3BP1 protein expres  Decreased viability  Decreased viability of wild-ty 

    Animal Models:
         Mouse knock-out Rpsatm1Ells for RPSA
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rpsa):
     cardiovascular system  craniofacial  endocrine/exocrine gland  growth/size  hematopoietic system 
     mortality/aging 

    RPSA for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Synthesis of PB1-F2
    8/26 pathways (see all 26)
    Viral Protein Synthesis1.00
    Cytoplasmic Ribosomal Proteins0.86
    Viral mRNA Translation1.00
    CFTR translational fidelity (class I mutations)0.83
    Influenza Viral RNA Transcription and Replication1.00
    SMG6 Cleaves mRNA with Premature Termination Codon0.80
    Synthesis of nascent polypeptide containing signal sequence1.00
    L13a-mediated translational silencing of Ceruloplasmin expression0.79
    2Translation initiation complex formation
    Translation initiation complex formation1.00
    Ribosomal scanning and start codon recognition0.96
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.98
    Formation of the ternary complex, and subsequently, the 43S complex0.87
    3Metabolism of mRNA
    Metabolism of mRNA1.00
    Metabolism of RNA0.92
    4Disease
    Disease1.00
    5Alpha6-Beta4 Integrin Signaling Pathway
    Alpha6-Beta4 Integrin Signaling Pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPSA
        CFTR translational fidelity (class I mutations)

    2 BioSystems Pathways for RPSA 
        Cytoplasmic Ribosomal Proteins
    Alpha6-Beta4 Integrin Signaling Pathway

    5/32        Reactome Pathways for RPSA (see all 32)
        Formation of a pool of free 40S subunits
    Synthesis of PB1-F2
    SMG6 Cleaves mRNA with Premature Termination Codon
    Influenza Life Cycle
    Viral mRNA Translation


    1         Kegg Pathway  (Kegg details for RPSA):
        Ribosome


    RPSA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RPSA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/221 Interacting proteins for RPSA (P088652, 3 ENSP000003460674) via UniProtKB, MINT, STRING, and/or I2D (see all 221)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000028ribosomal small subunit assembly IBA--
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA--
    GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA--
    GO:0006407rRNA export from nucleus IBA--


    RPSA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RPSA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RPSA
    10 Novoseek chemical compound relationships for RPSA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    egcg 72.9 47 18079119 (6), 15946647 (4), 19176763 (4), 18423375 (4) (see all 14)
    matrigel 40.4 2 11400912 (1), 19182490 (1)
    etoposide 27.4 1 19309222 (1)
    vincristine 17.5 2 12894554 (1)
    lipid 0 2 16140266 (2)
    steroid 0 1 1399148 (1)
    progesterone 0 2 14663356 (1), 10697509 (1)
    estrogen 0 6 8472397 (2), 10023712 (2), 14663356 (1), 10697509 (1)
    lactate 0 2 10999723 (1), 10499614 (1)
    cysteine 0 1 14595126 (1)

    Search CenterWatch for drugs/clinical trials and news about RPSA / RSSA 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RPSA gene (2 alternative transcripts): 
    NM_001012321.1  NM_002295.4  

    Unigene Cluster for RPSA:

    Ribosomal protein SA
    Hs.449909  [show with all ESTs]
    Unigene Representative Sequence: BC010054
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000301821(uc003cjp.3 uc003cjq.3) ENST00000477325 ENST00000475346
    ENST00000487876 ENST00000458478 ENST00000443003 ENST00000444512 ENST00000490490
    ENST00000478027 ENST00000495394

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    Additional cDNA sequence: 

    AF375472.1 AF503367.1 AJ609429.1 BC005391.1 BC008867.2 BC010054.1 BC010418.2 BC013827.2 
    BC018867.2 BC034537.1 BC050688.1 BC053370.1 BC062714.1 BC066941.1 BC068062.1 BC070263.1 
    BC071693.1 BC071968.1 BC071969.1 BC071970.1 BC073863.1 BC107567.1 BT007219.1 J03799.1 
    L07383.1 M14199.1 NR_002324.1 NR_002325.1 S37431.1 X15005.1 X61156.1 

    24/141 DOTS entries (see all 141):

    DT.100860380  DT.91786361  DT.95378186  DT.102842173  DT.97864862  DT.91786018  DT.100742431  DT.91786421 
    DT.100742381  DT.100801725  DT.87006252  DT.100742496  DT.95378228  DT.100854981  DT.85103296  DT.100742512 
    DT.100837399  DT.95377954  DT.100742468  DT.100742475  DT.95378263  DT.100742502  DT.95157976  DT.100637454 

    24/4855 AceView cDNA sequences (see all 4855):

    BG180002 BX462179 CB305450 BF792718 CR611940 BU175794 BM918981 BU849781 
    BM781990 BM788219 BF794872 BQ053162 BQ212765 BQ049394 AW250172 AW246788 
    BU187759 BQ941565 BQ932843 BU181336 AA977825 BU164147 BM784801 BF726735 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for RPSA (see all 14)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b
    SP1:              -     -     -                 -     -     -     -     -     -     -     -                 -                                             
    SP2:              -     -     -                 -     -     -     -           -     -     -                 -                                             
    SP3:                                            -     -     -     -                 -     -                 -                                             
    SP4:                                            -     -     -     -           -     -     -                 -                                             
    SP5:              -     -     -                 -     -     -     -           -     -     -                                                               


    ECgene alternative splicing isoforms for RPSA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPSA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAAAATGGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    RPSA expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Endoderm-like cells (Generation of hepato...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RPSA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPSA

    SOURCE GeneReport for Unigene cluster: Hs.449909
        SABiosciences Expression via Pathway-Focused PCR Array including RPSA: 
              Tumor Metastasis in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPSA gene from 8/33 species (see all 33)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves RPSA1 ribosomal protein SA 84.07(n)
    97.97(a)
      395181  NM_001007823.1  NP_001007824.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    --
    97(a)
    88(a)
    many ↔ many
    many ↔ many
    GL343224.1(2172607-2178135)
    4(126540318-126541058)
    African clawed frog
    (Xenopus laevis)
    Amphibia lamr1-prov2 laminin receptor 1 (ribosomal protein SA, 67 kDA) 81.4(n)    BC046271.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rpsa1 ribosomal protein SA 82.03(n)
    92.83(a)
      394027  NM_201052.1  NP_957346.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sta1 stubarista 63.41(n)
    64.66(a)
      31106  NM_057402.4  NP_476750.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rps-01 Protein RPS-0 60.78(n)
    59.77(a)
      175628  NM_065577.4  NP_497978.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons P401 40S ribosomal protein Sa-1 61.64(n)
    56.6(a)
      843569  NM_105896.3  NP_177381.1 
    rice
    (Oryza sativa)
    Liliopsida Os07g06166001 hypothetical protein 62.31(n)
    57.09(a)
      4343909  NM_001066812.1  NP_001060277.1 


    ENSEMBL Gene Tree for RPSA (if available)
    TreeFam Gene Tree for RPSA (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPSA gene
    RPSAP582  
    2 SIMAP similar genes for RPSA using alignment to 3 protein entries:     RSSA_HUMAN (see all proteins):
    LAMR1P15    RPSAP58

    RPSA for paralogs           About GeneDecksing


    5/54 Pseudogenes.org Pseudogenes for RPSA (see all 54)
    PGOHUM00000238358 PGOHUM00000251263 PGOHUM00000238843 PGOHUM00000250419 PGOHUM00000251001


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/230 NCBI SNPs in RPSA are shown (see all 230    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1822016381,2
    --39446237(+) GTGTAC/TGTTTC 1 -- us2k10--------
    rs98173471,2
    C,F,H,--39446253(+) ctgttA/Gatttg 1 -- us2k111Minor allele frequency- G:0.09NS EA NA WA 794
    rs21335791,2
    C,F,A,H,--39446288(+) TGAACA/GCTCAG 1 -- us2k118Minor allele frequency- G:0.24NS EA NA CSA WA 1422
    rs1480668731,2
    C,--39446290(+) AACACT/CCAGAG 1 -- us2k11Minor allele frequency- C:0.01NS 136
    rs1869322681,2
    --39446314(+) CCCCTA/GCAAGA 1 -- us2k10--------
    rs1916709011,2
    --39446353(+) CACTCA/TGAGAT 1 -- us2k10--------
    rs1437176821,2
    --39446372(+) ATTCA-/GCCCAGGTGTA
    AGATTTTAAAAGCT
    GCCCA
    1 -- us2k10--------
    rs1149812531,2
    --39446396(+) AAAGCA/TGCCCA 1 -- us2k10--------
    rs1401029591,2
    --39446440(+) GGAACC/TCTGCA 1 -- us2k10--------
    rs21736031,2
    C,F,A,--39446470(+) GCAATC/TCCAAT 1 -- us2k1 tfbs310Minor allele frequency- T:0.23NA CSA WA EA NS 594

    HapMap Linkage Disequilibrium report for RPSA (39448180 - 39454033 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RPSA: --

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RPSA for disorders           About GeneDecksing

    OMIM gene information: 150370   
    OMIM disorders: 604400  
    20/55 diseases for RPSA (see all 55):    About MalaCards
    colon carcinoma    arrhythmogenic right ventricular dysplasia    carcinoma    arrhythmogenic right ventricular dysplasia 5
    bovine spongiform encephalopathy    venezuelan equine encephalitis    lung cancer    diffuse large b-cell lymphoma
    west nile virus    b-cell lymphomas    bile duct carcinoma    cervical intraepithelial neoplasia
    gastrointestinal stromal tumor    chronic wasting disease    prion disease    laryngeal squamous cell carcinoma
    adenoid cystic carcinoma    lymphoblastic leukemia    squamous cell carcinoma    acute lymphoblastic leukemia

    2 diseases from the University of Copenhagen DISEASES database for RPSA:
    Scrapie     Bovine spongiform encephalopathy

    10/21 Novoseek disease relationships for RPSA gene (see all 21)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 42.9 23 8869283 (2), 19182490 (2), 10066078 (2), 15563845 (1) (see all 17)
    aggressiveness 42.4 6 15947111 (3), 11888899 (1), 16481804 (1), 19182490 (1)
    cancer 33 25 8655633 (3), 7654437 (2), 19367120 (2), 8911124 (1) (see all 20)
    tumors 31.1 62 9182980 (5), 15947111 (4), 11888899 (3), 12875970 (3) (see all 26)
    ovarian carcinoma 27.2 9 8911124 (4), 10537344 (4), 11562388 (1)
    carcinoma 27 25 8869283 (3), 9155714 (3), 10372715 (3), 9227340 (3) (see all 11)
    acute leukemia 16.1 1 16146788 (1)
    colorectal carcinoma 16.1 7 8869283 (2), 11299735 (2)
    breast carcinoma 15.7 5 10023712 (3), 10697509 (2)
    prion diseases 12.6 1 10878555 (1)


    Export disorders for RPSA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPSA gene, integrated from 9 sources (see all 210):
    (articles sorted by number of sources associating them with RPSA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation from a multigene family of the active human gene of the metastasis-associated multifunctional protein 37LRP/p40 at chromosome 3p21.3. (PubMed id 8760291)1, 2, 3, 9 Jackers P.... Castronovo V. (1996)
    2. Cloning of 67-kDa laminin receptor cDNA and gene expression in normal and malignant cell lines of the human lung. (PubMed id 1534510)1, 2, 3 Satoh K.... Motomiya M. (1992)
    3. 67-kDa laminin receptor promotes internalization of cytotoxic necrotizing factor 1-expressing Escherichia coli K1 into human brain microvascular endothelial cells. (PubMed id 15516338)1, 2, 9 Kim K.J....Kim K.S. (2005)
    4. The protein phosphatase-1 targeting subunit TIMAP reg ulates LAMR1 phosphorylation. (PubMed id 16263087)1, 2 Kim K....Ballermann B.J. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Ribosome-associated protein LBP/p40 binds to S21 protein of 40S ribosome: analysis using a yeast two-hybrid system. (PubMed id 10079194)1, 2 Sato M.... Kaneda Y. (1999)
    7. A map of 75 human ribosomal protein genes. (PubMed id 9582194)1, 2 Kenmochi N.... Page D.C. (1998)
    8. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699)1, 2 Vladimirov S.N.... Otto A. (1996)
    9. The gene for human E2 small nucleolar RNA resides in an intron of a laminin-binding protein gene. (PubMed id 8586453)1, 2 Selvamurugan N. and Eliceiri G.L. (1995)
    10. Characteristics of a multicopy gene family predominantly consisting of processed pseudogenes. (PubMed id 2543954)1, 2 van den Ouweland A.M.W.... van de Ven W.J.M. (1989)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3921 HGNC: 6502 AceView: LAMR1 Ensembl:ENSG00000168028 euGenes: HUgn3921
    ECgene: RPSA Kegg: 3921 H-InvDB: RPSA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPSA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RPSA Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RPSA gene:
    Search GeneIP for patents involving RPSA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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