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RPS9 Gene

protein-coding   GIFtS: 66
GCID: GC19P054866

Ribosomal Protein S9

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribosomal Protein S91 2
40S Ribosomal Protein S91 2
S92

External Ids:    HGNC: 104421   Entrez Gene: 62032   Ensembl: ENSG000001708897   OMIM: 6036315   UniProtKB: P467813   

Export aliases for RPS9 gene to outside databases

Previous GC identifers: GC19P055568 GC19P055129 GC19P059380 GC19P059396 GC19P054795 GC19P054800 GC19P051020 GC19P054806 GC19P054813 GC19P054820 GC19P054828 GC19P054842 GC19P054851


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RPS9 Gene:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This
gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S4P family of
ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers
compared to adjacent normal tissues has been observed, although no correlation between the level of expression
and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, multiple
processed pseudogenes derived from this gene are dispersed through the genome. (provided by RefSeq, Jul 2008)

GeneCards Summary for RPS9 Gene:
RPS9 (ribosomal protein S9) is a protein-coding gene. Diseases associated with RPS9 include treacher collins syndrome, and colorectal cancer. GO annotations related to this gene include structural constituent of ribosome and translation regulator activity.

Gene Wiki entry for RPS9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NT_187693.1  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPS9 gene promoter:
         NRSF form 1   XBP-1   NRSF form 2   NF-AT   AREB6   NF-AT4   NF-AT2   NF-AT3   NF-AT1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): RPS9 promoter sequence
   Search Chromatin IP Primers for RPS9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPS9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.4

RPS9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS9 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P054866:  view genomic region     (about GC identifiers)

Start:
54,704,610 bp from pter      End:
54,752,862 bp from pter
Size:
48,253 bases      Orientation:
plus strand

Selected alternative locations (see all 8):
Chr19+,NW_003571060 175,830-182,618      Chr19+,NW_003571061 175,839-182,628      Chr19+,NW_003571056 175,839-182,628     
Chr19+,NW_003571054 175,657-182,446      Chr19+,NW_003571055 175,839-182,628      Chr19+,NW_003571059 175,839-182,628     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RS9_HUMAN, P46781 (See protein sequence)
Recommended Name: 40S ribosomal protein S9  
Size: 194 amino acids; 22591 Da
Subunit: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs
1 PDB 3D structure from and Proteopedia for RPS9:
3J3A (3D)    
Secondary accessions: A9C4C1 Q4QRK7 Q9BVZ0

Explore the universe of human proteins at neXtProt for RPS9: NX_P46781

Explore proteomics data for RPS9 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys11, Lys30, Lys91, Lys93, Lys116, Lys121, Lys139, Lys155
  • Modification sites at PhosphoSitePlus

  • See RPS9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001004.2  
    ENSEMBL proteins: 
     ENSP00000302896   ENSP00000399623   ENSP00000406159   ENSP00000375632   ENSP00000383937  
     ENSP00000391823   ENSP00000375631   ENSP00000375633   ENSP00000414314  
    Reactome Protein details: P46781

    RPS9 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for RPS9


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RPS: S ribosomal proteins

    5 InterPro protein domains:
     IPR022801 Ribosomal_S4/S9
     IPR005710 Ribosomal_S4/S9_euk/arc
     IPR002942 S4_RNA-bd
     IPR001912 Ribosomal_S4/S9_N
     IPR018079 Ribosomal_S4_CS

    Graphical View of Domain Structure for InterPro Entry P46781

    ProtoNet protein and cluster: P46781

    2 Blocks protein domains:
    IPB001912 Ribosomal protein S4
    IPB002942 RNA-binding S4


    UniProtKB/Swiss-Prot: RS9_HUMAN, P46781
    Similarity: Belongs to the ribosomal protein S4P family
    Similarity: Contains 1 S4 RNA-binding domain


    RPS9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for RPS9:
    40S ribosomal protein S9

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding ----
    GO:0003735structural constituent of ribosome IEA--
    GO:0005515protein binding IPI18420587
    GO:0019843rRNA binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    RPS9 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for RPS9:
     Decreased G3BP1 protein expres  Decreased Hepatitis C virus re  Decreased viability  Increased gamma-H2AX phosphory 
     Nucleolar pre-40S maturation d 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RPS9
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RPS9
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RPS9

    miRNA
    Products:
        
    miRTarBase miRNAs that target RPS9:
    hsa-mir-1296-5p (MIRT036124), hsa-mir-328-3p (MIRT043770), hsa-mir-331-3p (MIRT043338), hsa-mir-935 (MIRT036686), hsa-mir-423-5p (MIRT038095), hsa-mir-342-3p (MIRT043674), hsa-mir-484 (MIRT042287), hsa-mir-10b-5p (MIRT047453), hsa-mir-766-3p (MIRT039014), hsa-mir-149-5p (MIRT045647), hsa-mir-10a-5p (MIRT047594)

    Block miRNA regulation of human, mouse, rat RPS9 using miScript Target Protectors
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RPS9

    Gene Editing
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RPS9 (NM_001013)
    Sino Biological Human cDNA Clone for RPS9
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPS9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS9

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS9


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RS9_HUMAN, P46781: Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005730nucleolus IDA18420587
    GO:0005737cytoplasm IDA18420587
    GO:0005829cytosol TAS--
    GO:0005840ribosome NAS7772601

    RPS9 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RPS9 About   (see all 6)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CFTR translational fidelity class I mutations
    CFTR translational fidelity class I mutations 0.60
    Ribosome0.54
    Cytoplasmic Ribosomal Proteins0.60
    2Influenza Viral RNA Transcription and Replication
    Viral mRNA Translation0.94
    Eukaryotic Translation Initiation0.89
    Peptide chain elongation0.94
    Cap-dependent Translation Initiation0.89
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    Formation of a pool of free 40S subunits0.94
    Nonsense-Mediated Decay0.89
    3Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
    Translation initiation complex formation0.91
    Ribosomal scanning and start codon recognition0.91
    Formation of the ternary complex, and subsequently, the 43S complex0.91
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.90
    4Gene Expression
    Gene Expression0.40
    5Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPS9
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPS9
        Cytoplasmic Ribosomal Proteins


    Selected Reactome Pathways for RPS9 (see all 12)
        Peptide chain elongation
    Formation of the ternary complex, and subsequently, the 43S complex
    Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
    Viral mRNA Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit


    1 Kegg Pathway  (Kegg details for RPS9):
        Ribosome


    RPS9 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RPS9
    Interactions:

        GeneGlobe Interaction Network for RPS9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPS9 (P467811, 2, 3 ENSP000003028964) via UniProtKB, MINT, STRING, and/or I2D (see all 684)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=2 
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    HIST1H4EP628053I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--
    GO:0006415translational termination TAS--

    RPS9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPS9 (RS9)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RPS9 gene: 
    NM_001013.3  

    Unigene Clusters for RPS9:

    Ribosomal protein S9
    Hs.467284  [show with all ESTs], Hs.546288  [show with all ESTs]
    Unigene Representative Sequences: BM916819, AK095055
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000302907(uc002qdx.3 uc002qdy.3) ENST00000484121 ENST00000448962
    ENST00000436445 ENST00000391752 ENST00000402367 ENST00000445961(uc002qec.3)
    ENST00000391751 ENST00000495002 ENST00000391753(uc002qea.3) ENST00000460761
    ENST00000441429(uc002qeb.3)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RPS9 (NM_001013)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat RPS9
      QuantiFast Probe-based Assays in human, mouse, rat RPS9

    Additional mRNA sequence: 

    AK095055.1 BC000802.1 BC007410.2 BC007434.2 BC007857.2 BC050660.1 BC058892.1 BC068055.1 
    BC071940.1 BC071941.1 BC096756.1 BC096822.1 U14971.1 

    Selected DOTS entries (see all 86):

    DT.100745892  DT.453641  DT.100060258  DT.100851421  DT.91952693  DT.100745901  DT.100060271  DT.100745999 
    DT.87000641  DT.97867493  DT.100746021  DT.121487083  DT.97857767  DT.100856853  DT.121504230  DT.121487207 
    DT.95238939  DT.100745961  DT.100846537  DT.121487693  DT.91796197  DT.121487090  DT.95238998  DT.40312422 

    Selected AceView cDNA sequences (see all 2245):

    CD513184 AI929451 BF026729 F24029 BG825772 BQ056230 H81556 BQ349541 
    BM853446 AI189910 BE781446 BX430788 BM808705 BX414229 BM825364 BM551496 
    BI829177 BQ424288 AJ711188 AW613867 CA866526 AI879674 CD174935 BQ072854 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RPS9    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
    SP1:        -                 -           -               
    SP2:                          -                           
    SP3:                                                      
    SP4:                                                      


    ECgene alternative splicing isoforms for RPS9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RPS9 expression in normal human tissues (normalized intensities)      RPS9 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAGTGGCCC
    RPS9 Expression
    About this image


    RPS9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Ovary (Reproductive System)
             Primary Oocyte Primary Follicle
     
     Gonad
             Primary Oocyte Primary Follicle
     
     Endoderm (Gastrulation Derivatives)
             Endoderm-like cells
     
     Tonsil (Hematopoietic System)
    RPS9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPS9 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.467284 Hs.546288
        Custom PCR Arrays for RPS9
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat RPS9
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPS9 gene from Selected species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rps91 , 5 ribosomal protein S91, 5 88.14(n)1
    100(a)1
      7 (2.13 cM)5
    768461  NM_029767.21  NP_084043.11 
     37039935 
    lizard
    (Anolis carolinensis)
    Reptilia RPS96
    ribosomal protein S9
    97(a)
    1 ↔ 1
    GL343329.1(607905-610929)
    African clawed frog
    (Xenopus laevis)
    Amphibia rps9-prov2 ribosomal protein S9 80.13(n)    BC041242.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rps92 ribosomal protein S9 78.76(n)   114420  BC059492.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RpS91 , 3 protein biosynthesis structural
    constituent of more3
    Ribosomal protein S91
    76(a)3
    77.36(n)1
    87.7(a)1
      67B103
    391081  NM_079280.41  NP_524004.21 
    worm
    (Caenorhabditis elegans)
    Secernentea rps-91 , 3 ribosomal protein S93
    rps-91
    81(a)3
    71.96(n)1
    83.53(a)1
      II(11125316-11126430)3
    1746991  NM_063983.41  NP_496384.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPS9A(YPL081W)4
    RPS9B1
    Protein component of the small (40S) ribosomal subunit; more4
    RPS9B1
    60.87(n)1
    71.2(a)1
      16(404950-406044)4
    8524871  NP_009748.31  8560244 
     NP_015244.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G152001 AT5G15200 65.22(n)
    71.2(a)
      831372  NM_121524.4  NP_197024.1 
    rice
    (Oryza sativa)
    Liliopsida CF333493.12   -- 70.43(n)    CF333493.1 


    ENSEMBL Gene Tree for RPS9 (if available)
    TreeFam Gene Tree for RPS9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RPS9 gene

    RPS9 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for RPS9
    PGOHUM00000234372 PGOHUM00000239171 PGOHUM00000235711


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RPS9 (see all 335)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0365434
    A breast cancer sample4--see VAR_0365432 V F mis40--------
    rs785696101,2
    C,F--54702745(+) GTACAC/GAAGAC 1 -- us2k11Minor allele frequency- G:0.06WA 118
    rs1507439431,2
    F--54702790(+) TTACTC/ATAAAT 1 -- us2k11Minor allele frequency- A:0.02NS 114
    rs1837203021,2
    --54703005(+) TTCATA/CCTGAA 1 -- us2k10--------
    rs1402100891,2
    C--54703112(+) GCCAGA/GCATGG 1 -- us2k10--------
    rs1511590241,2
    C--54703230(+) CAACA-/AAAC  
            
    AAACA
    1 -- us2k10--------
    rs566776471,2
    C--54703245(+) ACAAA-/CAAA  
            
    AAACC
    1 -- us2k10--------
    rs1885959391,2
    --54703253(+) ACCCAC/TAAAAC 1 -- us2k10--------
    rs1932761261,2
    --54703266(+) AACAAC/GGTAGT 1 -- us2k10--------
    rs1425095641,2
    C--54703418(+) TTCGCC/TGTTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RPS9 (54704610 - 54752862 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RPS9 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718812CNV Deletion23290073
    essv101799CNV Loss18971310
    nsv912399CNV Loss21882294
    nsv458783CNV Loss19166990
    nsv510774CNV Loss20534489
    nsv2546CNV Loss18451855
    dgv432n27CNV Loss19166990
    dgv4002n71CNV Loss21882294
    nsv428371CNV Gain+Loss18775914
    dgv1122e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RPS9
    DNA2.0 Custom Variant and Variant Library Synthesis for RPS9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603631    OMIM disorders: --

    8 diseases for RPS9:    About MalaCards
    treacher collins syndrome    colorectal cancer    influenza    breast and colorectal cancer
    prostate cancer    prostatitis    breast cancer    malaria


    RPS9 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RPS9
    Human Genome Epidemiology (HuGE) Navigator: RPS9 (1 document)

    Export disorders for RPS9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RPS9 gene, integrated from 10 sources (see all 74):
    (articles sorted by number of sources associating them with RPS9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A map of 75 human ribosomal protein genes. (PubMed id 9582194)1, 2, 3 Kenmochi N.... Page D.C. (Genome Res. 1998)
    2. Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs. (PubMed id 7772601)1, 2, 3 Frigerio J.-M.... Iovanna J.L. (Biochim. Biophys. Acta 1995)
    3. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (PLoS Genet. 2009)
    4. Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)1, 2 Joeson L.... Nielsen F.C. (Mol. Cell. Proteomics 2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PubMed id 11875025)1, 2 Yoshihama M.... Kenmochi N. (Genome Res. 2002)
    7. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699)1, 2 Vladimirov S.N.... Otto A. (Eur. J. Biochem. 1996)
    8. Ribosomal protein S9 is a novel B23/NPM-binding protein required for normal cell proliferation. (PubMed id 18420587)1, 9 LindstrAPm M.S. and Zhang Y. (J. Biol. Chem. 2008)
    9. Silencing of ribosomal protein S9 elicits a multitude of cellular responses inhibiting the growth of cancer cells subsequent to p53 activation. (PubMed id 20221446)1, 9 LindstrAPm M.S. and NistAcr M. (PLoS ONE 2010)
    10. Identification of genes responsive to BPDE treatment in HeLa cells using cDNA expression assays. (PubMed id 11044901)1, 9 Yu Z....Glickman B.W. (Environ. Mol. Mutagen. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6203 HGNC: 10442 AceView: RPS9 Ensembl:ENSG00000170889 euGenes: HUgn6203
    ECgene: RPS9 Kegg: 6203 H-InvDB: RPS9

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RPS9 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RPS9 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RPS9 gene:
    Search GeneIP for patents involving RPS9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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