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Aliases for RPS9 Gene

Aliases for RPS9 Gene

  • Ribosomal Protein S9 2 3 5
  • 40S Ribosomal Protein S9 2
  • S9 3

External Ids for RPS9 Gene

Previous GeneCards Identifiers for RPS9 Gene

  • GC19P055568
  • GC19P055129
  • GC19P059380
  • GC19P059396
  • GC19P054795
  • GC19P054800
  • GC19P051020
  • GC19P054806
  • GC19P054813
  • GC19P054820
  • GC19P054828
  • GC19P054842
  • GC19P054851
  • GC19P054866
  • GC19P054357
  • GC19P054370

Summaries for RPS9 Gene

Entrez Gene Summary for RPS9 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S4P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, multiple processed pseudogenes derived from this gene are dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS9 Gene

RPS9 (Ribosomal Protein S9) is a Protein Coding gene. Among its related pathways are Gene Expression and Metabolism. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPS9 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS9 Gene

Genomics for RPS9 Gene

Regulatory Elements for RPS9 Gene

Promoters for RPS9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPS9 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPS9 Gene

Chromosome:
19
Start:
54,200,557 bp from pter
End:
54,249,003 bp from pter
Size:
48,447 bases
Orientation:
Plus strand

Genomic View for RPS9 Gene

Genes around RPS9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS9 Gene

Proteins for RPS9 Gene

  • Protein details for RPS9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46781-RS9_HUMAN
    Recommended name:
    40S ribosomal protein S9
    Protein Accession:
    P46781
    Secondary Accessions:
    • A9C4C1
    • Q4QRK7
    • Q9BVZ0

    Protein attributes for RPS9 Gene

    Size:
    194 amino acids
    Molecular mass:
    22591 Da
    Quaternary structure:
    • Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.

    Three dimensional structures from OCA and Proteopedia for RPS9 Gene

neXtProt entry for RPS9 Gene

Proteomics data for RPS9 Gene at MOPED

Post-translational modifications for RPS9 Gene

  • Ubiquitination at Lys 11, Lys 30, Lys 91, Lys 93, Lys 116, Lys 121, Lys 139, and Lys 155
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPS9 Gene

Domains & Families for RPS9 Gene

Gene Families for RPS9 Gene

Suggested Antigen Peptide Sequences for RPS9 Gene

Graphical View of Domain Structure for InterPro Entry

P46781

UniProtKB/Swiss-Prot:

RS9_HUMAN :
  • Contains 1 S4 RNA-binding domain.
  • Belongs to the ribosomal protein S4P family.
Domain:
  • Contains 1 S4 RNA-binding domain.
Family:
  • Belongs to the ribosomal protein S4P family.
genes like me logo Genes that share domains with RPS9: view

Function for RPS9 Gene

Molecular function for RPS9 Gene

GENATLAS Biochemistry:
40S ribosomal protein S9

Gene Ontology (GO) - Molecular Function for RPS9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18420587
GO:0045182 translation regulator activity IMP 18420587
genes like me logo Genes that share ontologies with RPS9: view
genes like me logo Genes that share phenotypes with RPS9: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS9 Gene

Localization for RPS9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS9 Gene

Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS9 Gene COMPARTMENTS Subcellular localization image for RPS9 gene
Compartment Confidence
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPS9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005840 ribosome NAS 7772601
GO:0015935 small ribosomal subunit IEA --
GO:0016020 membrane IDA 19946888
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with RPS9: view

Pathways & Interactions for RPS9 Gene

SuperPathways for RPS9 Gene

Superpath Contained pathways
1 Viral mRNA Translation
.60
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing
5 Infectious disease
.48
genes like me logo Genes that share pathways with RPS9: view

Pathways by source for RPS9 Gene

1 BioSystems pathway for RPS9 Gene
1 KEGG pathway for RPS9 Gene
1 GeneGo (Thomson Reuters) pathway for RPS9 Gene

Gene Ontology (GO) - Biological Process for RPS9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS --
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
GO:0016032 viral process TAS --
GO:0019058 viral life cycle TAS --
genes like me logo Genes that share ontologies with RPS9: view

No data available for SIGNOR curated interactions for RPS9 Gene

Drugs & Compounds for RPS9 Gene

No Compound Related Data Available

Transcripts for RPS9 Gene

Unigene Clusters for RPS9 Gene

Ribosomal protein S9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPS9 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP1: - - -
SP2: -
SP3:
SP4:

Relevant External Links for RPS9 Gene

GeneLoc Exon Structure for
RPS9
ECgene alternative splicing isoforms for
RPS9

Expression for RPS9 Gene

mRNA expression in normal human tissues for RPS9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPS9 Gene

This gene is overexpressed in Tlymphocyte (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS9 Gene



SOURCE GeneReport for Unigene cluster for RPS9 Gene Hs.467284

genes like me logo Genes that share expression patterns with RPS9: view

Protein tissue co-expression partners for RPS9 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS9 Gene

Orthologs for RPS9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPS9 35
  • 99.48 (n)
  • 100 (a)
-- 36
  • 97 (a)
OneToMany
-- 36
  • 100 (a)
OneToMany
cow
(Bos Taurus)
Mammalia RPS9 36
  • 100 (a)
OneToOne
RPS9 35
  • 93.13 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia RPS9 35
  • 91.41 (n)
  • 100 (a)
RPS9 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rps9 16
Rps9 36
  • 100 (a)
OneToOne
Rps9 35
  • 88.14 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia RPS9 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPS9 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rps9 35
  • 87.46 (n)
  • 100 (a)
lizard
(Anolis carolinensis)
Reptilia RPS9 36
  • 97 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia rps9-prov 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9769 35
zebrafish
(Danio rerio)
Actinopterygii rps9 35
  • 77.66 (n)
  • 94.85 (a)
rps9 36
  • 95 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005061 35
  • 77.18 (n)
  • 87.17 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpS9 35
  • 77.36 (n)
  • 87.7 (a)
RpS9 36
  • 84 (a)
OneToOne
RpS9 37
  • 76 (a)
worm
(Caenorhabditis elegans)
Secernentea rps-9 36
  • 80 (a)
OneToOne
rps-9 35
  • 71.96 (n)
  • 83.53 (a)
rps-9 37
  • 81 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL255W 35
  • 69.48 (n)
  • 77.11 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS9A 38
RPS9B 36
  • 68 (a)
OneToMany
RPS9A 36
  • 68 (a)
OneToMany
RPS9B 35
  • 60.87 (n)
  • 71.2 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E23673g 35
  • 65.26 (n)
  • 75.9 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2888 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G15200 35
  • 65.22 (n)
  • 71.2 (a)
corn
(Zea mays)
Liliopsida Zm.7072 35
rice
(Oryza sativa)
Liliopsida Os03g0154700 35
  • 68.13 (n)
  • 69.78 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.23050 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01949 35
  • 73.04 (n)
  • 78.14 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps901 35
  • 67.27 (n)
  • 81.33 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2684 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5674 36
  • 90 (a)
OneToOne
Species with no ortholog for RPS9:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for RPS9 Gene

ENSEMBL:
Gene Tree for RPS9 (if available)
TreeFam:
Gene Tree for RPS9 (if available)

Paralogs for RPS9 Gene

Pseudogenes.org Pseudogenes for RPS9 Gene

genes like me logo Genes that share paralogs with RPS9: view

No data available for Paralogs for RPS9 Gene

Variants for RPS9 Gene

Sequence variations from dbSNP and Humsavar for RPS9 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_052069 -
VAR_036543 A breast cancer sample

Structural Variations from Database of Genomic Variants (DGV) for RPS9 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
dgv4002n71 CNV Loss 21882294
nsv510774 CNV Loss 20534489
dgv1118e1 CNV Complex 17122850
nsv428371 CNV Gain+Loss 18775914
dgv1119e1 CNV Complex 17122850
nsv2546 CNV Loss 18451855
nsv458783 CNV Loss 19166990
essv101799 CNV Loss 18971310
dgv1120e1 CNV Complex 17122850
dgv1121e1 CNV Complex 17122850
dgv1122e1 CNV Complex 17122850
dgv432n27 CNV Loss 19166990
nsv912399 CNV Loss 21882294

Variation tolerance for RPS9 Gene

Residual Variation Intolerance Score: 33% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 2.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS9 Gene

HapMap Linkage Disequilibrium report
RPS9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS9 Gene

Disorders for RPS9 Gene

Relevant External Links for RPS9

Genetic Association Database (GAD)
RPS9
Human Genome Epidemiology (HuGE) Navigator
RPS9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPS9

No disorders were found for RPS9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPS9 Gene

Publications for RPS9 Gene

  1. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3 4 67
  2. Silencing of ribosomal protein S9 elicits a multitude of cellular responses inhibiting the growth of cancer cells subsequent to p53 activation. (PMID: 20221446) LindstrAPm M.S. … NistAcr M. (PLoS ONE 2010) 3 23
  3. Ribosomal protein S9 is a novel B23/NPM-binding protein required for normal cell proliferation. (PMID: 18420587) LindstrAPm M.S. … Zhang Y. (J. Biol. Chem. 2008) 3 23
  4. Identification of genes responsive to BPDE treatment in HeLa cells using cDNA expression assays. (PMID: 11044901) Yu Z. … Glickman B.W. (Environ. Mol. Mutagen. 2000) 3 23
  5. Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs. (PMID: 7772601) Frigerio J.-M. … Iovanna J.L. (Biochim. Biophys. Acta 1995) 2 3

Products for RPS9 Gene

Sources for RPS9 Gene

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