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Aliases for RPS9 Gene

Aliases for RPS9 Gene

  • Ribosomal Protein S9 2 3 5
  • 40S Ribosomal Protein S9 2 3
  • S9 3

External Ids for RPS9 Gene

Previous GeneCards Identifiers for RPS9 Gene

  • GC19P055568
  • GC19P055129
  • GC19P059380
  • GC19P059396
  • GC19P054795
  • GC19P054800
  • GC19P051020
  • GC19P054806
  • GC19P054813
  • GC19P054820
  • GC19P054828
  • GC19P054842
  • GC19P054851
  • GC19P054866
  • GC19P054357
  • GC19P054370
  • GC19P054380

Summaries for RPS9 Gene

Entrez Gene Summary for RPS9 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S4P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, multiple processed pseudogenes derived from this gene are dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS9 Gene

RPS9 (Ribosomal Protein S9) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Transport to the Golgi and subsequent modification. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPS9 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS9 Gene

Genomics for RPS9 Gene

Regulatory Elements for RPS9 Gene

Enhancers for RPS9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around RPS9 on UCSC Golden Path with GeneCards custom track

Promoters for RPS9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for RPS9 Gene

Chromosome:
19
Start:
54,200,557 bp from pter
End:
54,249,003 bp from pter
Size:
48,447 bases
Orientation:
Plus strand

Genomic View for RPS9 Gene

Genes around RPS9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS9 Gene

Proteins for RPS9 Gene

  • Protein details for RPS9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46781-RS9_HUMAN
    Recommended name:
    40S ribosomal protein S9
    Protein Accession:
    P46781
    Secondary Accessions:
    • A9C4C1
    • Q4QRK7
    • Q9BVZ0

    Protein attributes for RPS9 Gene

    Size:
    194 amino acids
    Molecular mass:
    22591 Da
    Quaternary structure:
    • Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.

    Three dimensional structures from OCA and Proteopedia for RPS9 Gene

neXtProt entry for RPS9 Gene

Post-translational modifications for RPS9 Gene

  • Ubiquitination at Lys 11, Lys 30, Lys 91, Lys 93, Lys 116, Lys 121, Lys 139, and Lys 155
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPS9 Gene

Domains & Families for RPS9 Gene

Gene Families for RPS9 Gene

Suggested Antigen Peptide Sequences for RPS9 Gene

Graphical View of Domain Structure for InterPro Entry

P46781

UniProtKB/Swiss-Prot:

RS9_HUMAN :
  • Contains 1 S4 RNA-binding domain.
  • Belongs to the ribosomal protein S4P family.
Domain:
  • Contains 1 S4 RNA-binding domain.
Family:
  • Belongs to the ribosomal protein S4P family.
genes like me logo Genes that share domains with RPS9: view

Function for RPS9 Gene

Molecular function for RPS9 Gene

GENATLAS Biochemistry:
40S ribosomal protein S9

Gene Ontology (GO) - Molecular Function for RPS9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IBA --
GO:0005515 protein binding IPI 18420587
GO:0019843 rRNA binding IBA --
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0045182 translation regulator activity IMP 18420587
genes like me logo Genes that share ontologies with RPS9: view
genes like me logo Genes that share phenotypes with RPS9: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS9 Gene

Localization for RPS9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS9 Gene

Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS9 Gene COMPARTMENTS Subcellular localization image for RPS9 gene
Compartment Confidence
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPS9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA 18420587
GO:0005737 cytoplasm IDA 18420587
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RPS9: view

Pathways & Interactions for RPS9 Gene

SuperPathways for RPS9 Gene

Superpath Contained pathways
1 Viral mRNA Translation
.60
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing
5 Infectious disease
.48
genes like me logo Genes that share pathways with RPS9: view

Gene Ontology (GO) - Biological Process for RPS9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IMP 18420587
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPS9: view

No data available for SIGNOR curated interactions for RPS9 Gene

Drugs & Compounds for RPS9 Gene

No Compound Related Data Available

Transcripts for RPS9 Gene

Unigene Clusters for RPS9 Gene

Ribosomal protein S9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS9 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP1: - - -
SP2: -
SP3:
SP4:

Relevant External Links for RPS9 Gene

GeneLoc Exon Structure for
RPS9
ECgene alternative splicing isoforms for
RPS9

Expression for RPS9 Gene

mRNA expression in normal human tissues for RPS9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPS9 Gene

This gene is overexpressed in Tlymphocyte (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPS9 Gene



Protein tissue co-expression partners for RPS9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS9 Gene:

RPS9

SOURCE GeneReport for Unigene cluster for RPS9 Gene:

Hs.467284
genes like me logo Genes that share expression patterns with RPS9: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS9 Gene

Orthologs for RPS9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPS9 34
  • 93.13 (n)
  • 100 (a)
RPS9 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPS9 34
  • 91.41 (n)
  • 100 (a)
RPS9 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rps9 34
  • 88.14 (n)
  • 100 (a)
Rps9 16
Rps9 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPS9 34
  • 99.48 (n)
  • 100 (a)
-- 35
  • 100 (a)
OneToMany
-- 35
  • 97 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rps9 34
  • 87.46 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia RPS9 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPS9 35
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPS9 35
  • 97 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia rps9-prov 34
zebrafish
(Danio rerio)
Actinopterygii rps9 34
  • 77.66 (n)
  • 94.85 (a)
rps9 35
  • 95 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9769 34
fruit fly
(Drosophila melanogaster)
Insecta RpS9 36
  • 76 (a)
RpS9 34
  • 77.36 (n)
  • 87.7 (a)
RpS9 35
  • 84 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005061 34
  • 77.18 (n)
  • 87.17 (a)
worm
(Caenorhabditis elegans)
Secernentea rps-9 36
  • 81 (a)
rps-9 34
  • 71.96 (n)
  • 83.53 (a)
rps-9 35
  • 80 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL255W 34
  • 69.48 (n)
  • 77.11 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E23673g 34
  • 65.26 (n)
  • 75.9 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS9B 34
  • 60.87 (n)
  • 71.2 (a)
RPS9A 35
  • 68 (a)
OneToMany
RPS9B 35
  • 68 (a)
OneToMany
RPS9A 37
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G15200 34
  • 65.22 (n)
  • 71.2 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2888 34
rice
(Oryza sativa)
Liliopsida Os03g0154700 34
  • 68.13 (n)
  • 69.78 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.23050 34
corn
(Zea mays)
Liliopsida Zm.7072 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2684 34
bread mold
(Neurospora crassa)
Ascomycetes NCU01949 34
  • 73.04 (n)
  • 78.14 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps901 34
  • 67.27 (n)
  • 81.33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5674 35
  • 90 (a)
OneToOne
Species where no ortholog for RPS9 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for RPS9 Gene

ENSEMBL:
Gene Tree for RPS9 (if available)
TreeFam:
Gene Tree for RPS9 (if available)

Paralogs for RPS9 Gene

Pseudogenes.org Pseudogenes for RPS9 Gene

genes like me logo Genes that share paralogs with RPS9: view

No data available for Paralogs for RPS9 Gene

Variants for RPS9 Gene

Sequence variations from dbSNP and Humsavar for RPS9 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_052069 -
VAR_036543 A breast cancer sample

Structural Variations from Database of Genomic Variants (DGV) for RPS9 Gene

Variant ID Type Subtype PubMed ID
dgv432n27 CNV loss 19166990
esv2718812 CNV deletion 23290073
esv2756707 CNV loss 18971310
esv2758771 CNV gain+loss 17122850
nsv1066425 CNV gain 25217958
nsv2546 CNV deletion 18451855
nsv428371 CNV gain+loss 18775914
nsv458783 CNV loss 19166990
nsv510774 CNV deletion 20534489
nsv580148 CNV loss 21841781
nsv580149 CNV gain 21841781
nsv580150 CNV loss 21841781

Variation tolerance for RPS9 Gene

Residual Variation Intolerance Score: 33% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 2.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPS9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS9 Gene

Disorders for RPS9 Gene

Relevant External Links for RPS9

Genetic Association Database (GAD)
RPS9
Human Genome Epidemiology (HuGE) Navigator
RPS9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPS9

No disorders were found for RPS9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPS9 Gene

Publications for RPS9 Gene

  1. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3 4 65
  2. Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs. (PMID: 7772601) Frigerio J.-M. … Iovanna J.L. (Biochim. Biophys. Acta 1995) 2 3 4 65
  3. Silencing of ribosomal protein S9 elicits a multitude of cellular responses inhibiting the growth of cancer cells subsequent to p53 activation. (PMID: 20221446) LindstrAPm M.S. … NistAcr M. (PLoS ONE 2010) 3 22 65
  4. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler H.E. … Kim S.K. (PLoS Genet. 2009) 3 46 65
  5. Ribosomal protein S9 is a novel B23/NPM-binding protein required for normal cell proliferation. (PMID: 18420587) LindstrAPm M.S. … Zhang Y. (J. Biol. Chem. 2008) 3 22 65

Products for RPS9 Gene

Sources for RPS9 Gene

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