Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPS8 Gene

protein-coding   GIFtS: 59
GCID: GC01P045240

Ribosomal Protein S8

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ribosomal Protein S81 2
40S Ribosomal Protein S82
OK/SW-cl.832
S82

External Ids:    HGNC: 104411   Entrez Gene: 62022   Ensembl: ENSG000001429377   OMIM: 6003575   UniProtKB: P622413   

Export aliases for RPS8 gene to outside databases

Previous GC identifers: GC01P044968 GC01P044241 GC01P044671 GC01P044654 GC01P044914 GC01P044915 GC01P044918 GC01P044927 GC01P045013


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RPS8 Gene:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This
gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S8E family of
ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal tumors and
colon polyps compared to matched normal colonic mucosa has been observed. This gene is co-transcribed with the
small nucleolar RNA genes U38A, U38B, U39, and U40, which are located in its fourth, fifth, first, and second
introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed
pseudogenes of this gene dispersed through the genome. (provided by RefSeq, Jul 2008)

GeneCards Summary for RPS8 Gene: 
RPS8 (ribosomal protein S8) is a protein-coding gene. Diseases associated with RPS8 include colonic polyps, and influenza, and among its related super-pathways are Eukaryotic Translation Initiation and Formation of the ternary complex, and subsequently, the 43S complex. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for RPS8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPS8 gene promoter:
         AP-1   SRF (504 AA)   ATF-2   Nkx2-5   RelA   Gfi-1   E47   Hand1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPS8 promoter sequence
   Search SABiosciences Chromatin IP Primers for RPS8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.1-p32   Ensembl cytogenetic band:  1p34.1   HGNC cytogenetic band: 1p34.1-p32

RPS8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS8 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P045240:  view genomic region     (about GC identifiers)

Start:
45,240,923 bp from pter      End:
45,244,451 bp from pter
Size:
3,529 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RS8_HUMAN, P62241 (See protein sequence)
Recommended Name: 40S ribosomal protein S8  
Size: 208 amino acids; 24205 Da
Subunit: Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1,
HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1,
RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs
Subcellular location: Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs
1 PDB 3D structure from and Proteopedia for RPS8:
3J3A (3D)    
Secondary accessions: P09058 Q6IRL7

Explore the universe of human proteins at neXtProt for RPS8: NX_P62241

Explore proteomics data for RPS8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P62241

  • RPS8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RPS8 Protein Expression
    REFSEQ proteins: NP_001003.1  
    ENSEMBL proteins: 
     ENSP00000379888   ENSP00000361283  
    Reactome Protein details: P62241
    Human Recombinant Protein Products for RPS8: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for RPS8
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for RPS8
    GenScript Custom Purified and Recombinant Proteins Services for RPS8
    Novus Biologicals RPS8 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RPS8 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005840ribosome ----
    GO:0022627cytosolic small ribosomal subunit TAS8432552

    RPS8 for ontologies           About GeneDecksing



    RPS8 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RPS8
    GenScript Custom Superior Antibodies Services for RPS8
    Novus Biologicals RPS8 Antibodies
    Abcam antibodies for RPS8
    Cloud-Clone Corp. Antibodies for RPS8 
    ThermoFisher Antibodies for RPS8
    LSBio Antibodies in human, mouse, rat for RPS8 

    Assay Products for RPS8: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RPS8
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RPS8
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RPS8 
    Cloud-Clone Corp. CLIAs for RPS8


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RPS: S ribosomal proteins

    3 InterPro protein domains:
     IPR001047 Ribosomal_S8e
     IPR018283 Ribosomal_S8e_CS
     IPR022309 Ribosomal_S8e/biogenesis_NSA2

    Graphical View of Domain Structure for InterPro Entry P62241

    ProtoNet protein and cluster: P62241

    UniProtKB/Swiss-Prot: RS8_HUMAN, P62241
    Similarity: Belongs to the ribosomal protein S8e family


    RPS8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for RPS8:
    40S ribosomal protein S8,24kDa

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome IBA--
         
    RPS8 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for RPS8:
     Decreased Hepatitis C virus re  Decreased cell number, increas  Decreased viability  Decreased viability of wild-ty 
     Nucleolar pre-40S maturation d  S arrest 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RPS8 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RPS8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RPS8 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RPS8 

    10/619 SABiosciences Target genes for RPS8 (see all 619):
    ABCD3 ACVR1C ACVR2A ADAMTS2 ADAMTSL2 ADH4 ADH5 ADNP2 AFF2 AGAP11

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPS8
    1 QIAGEN miScript miRNA Assays for microRNA that regulate RPS8:
    hsa-miR-556-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RPS8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS8

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RPS8
    Sirion Biotech Customized adenovirus for overexpression of RPS8

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RPS8 (see all 8)
    OriGene ORF clones in mouse, rat for RPS8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RPS8 (NM_001012)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPS8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS8
    Sirion Biotech Customized lentivirus for stable overexpression of RPS8 
                         Customized lentivirus expression plasmids for stable overexpression of RPS8 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RPS8
    Search LifeMap BioReagents cell lines for RPS8
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS8


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RPS8 About   (see all 6)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Viral mRNA Translation
    Influenza Life Cycle0.95
    3' -UTR-mediated translational regulation0.93
    Influenza Infection0.95
    L13a-mediated translational silencing of Ceruloplasmin expression0.93
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Formation of a pool of free 40S subunits0.90
    Eukaryotic Translation Termination0.94
    Nonsense-Mediated Decay0.84
    2Translation initiation complex formation
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.95
    Formation of the ternary complex, and subsequently, the 43S complex0.87
    Ribosomal scanning and start codon recognition0.95
    Translation initiation complex formation0.87
    3Metabolism of mRNA
    Metabolism of mRNA0.92
    Metabolism of RNA0.92
    4Generic Transcription Pathway
    Gene Expression0.47
    5Asparagine N-linked glycosylation
    Metabolism of proteins0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPS8
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPS8
        Cytoplasmic Ribosomal Proteins

    5/27        Reactome Pathways for RPS8 (see all 27)
        Formation of the ternary complex, and subsequently, the 43S complex
    Nonsense Mediated Decay Independent of the Exon Junction Complex
    Nonsense-Mediated Decay
    Translation
    SRP-dependent cotranslational protein targeting to membrane


    1         Kegg Pathway  (Kegg details for RPS8):
        Ribosome


    RPS8 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPS8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/468 Interacting proteins for RPS8 (P622411, 2, 3 ENSP000003798884) via UniProtKB, MINT, STRING, and/or I2D (see all 468)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=2 
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    HIST1H4EP628053I2D: score=2 
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0000462maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--

    RPS8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RPS8 (RS8)

    Search CenterWatch for drugs/clinical trials and news about RPS8 / RS8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RPS8 gene: 
    NM_001012.1  

    Unigene Cluster for RPS8:

    Ribosomal protein S8
    Hs.512675  [show with all ESTs]
    Unigene Representative Sequence: BG033629
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000497035 ENST00000396651(uc001cmi.3) ENST00000372209 ENST00000470475
    ENST00000485390 ENST00000464658 ENST00000484599 ENST00000474582
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPS8
    1 QIAGEN miScript miRNA Assays for microRNA that regulate RPS8:
    hsa-miR-556-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RPS8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS8
    Clone
    Products:
         
    OriGene clones in human, mouse for RPS8 (see all 8)
    OriGene ORF clones in mouse, rat for RPS8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RPS8 (NM_001012)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPS8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS8
    Sirion Biotech Customized lentivirus for stable overexpression of RPS8 
                         Customized lentivirus expression plasmids for stable overexpression of RPS8 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RPS8
    OriGene qSTAR qPCR primer pairs in human, mouse for RPS8
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RPS8
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS8

    Additional mRNA sequence: 

    AB062401.1 AF116700.1 AK311854.1 BC005678.1 BC022070.1 BC070875.1 

    24/104 DOTS entries (see all 104):

    DT.91653431  DT.97867907  DT.91889352  DT.91975620  DT.85102408  DT.121388170  DT.95145235  DT.100726298 
    DT.91999339  DT.91894031  DT.95083095  DT.95258454  DT.121388318  DT.91828949  DT.99985027  DT.97857401 
    DT.91697190  DT.121388242  DT.100726305  DT.100726322  DT.100836107  DT.121388223  DT.100726295  DT.121388222 

    24/485 AceView cDNA sequences (see all 485):

    NR_001456 AI815502 AA064884 CD512888 AI707921 BM263274 BQ646669 BQ639596 
    BQ066175 F30384 CB140494 T58987 BQ652979 AI915069 BQ946190 BE296912 
    AI866866 AA581971 BU076266 AA076378 AB062401 X97582 NM_001012 BC070875 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for RPS8 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c ^ 8
    SP1:        -     -     -     -     -                       -     -                                 
    SP2:                    -     -     -                       -     -                                 
    SP3:                                                        -     -                                 
    SP4:                                                  -     -     -                                 
    SP5:                                                        -     -                                 


    ECgene alternative splicing isoforms for RPS8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPS8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATAAAGGT
    RPS8 Expression
    About this image


    See RPS8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPS8

    SOURCE GeneReport for Unigene cluster: Hs.512675
        SABiosciences Custom PCR Arrays for RPS8
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RPS8
    OriGene qSTAR qPCR primer pairs in human, mouse for RPS8
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RPS8
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS8
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPS8 gene from 10/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rps81 , 5 ribosomal protein S81, 5 90.06(n)1
    100(a)1
      4 (53.41 cM)5
    201161  NM_009098.21  NP_033124.11 
     1171538275 
    chicken
    (Gallus gallus)
    Aves RPS81 ribosomal protein S8 83.17(n)
    97.6(a)
      424584  NM_001252126.1  NP_001239055.1 
    lizard
    (Anolis carolinensis)
    Reptilia RPS86
    40S ribosomal protein S8
    98(a)
    1 ↔ 1
    4(111055199-111061900)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX847483.12   -- 91.44(n)    BX847483.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BI476728.12   -- 79.94(n)   326946  BI476728.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG78083 protein biosynthesis structural
    constituent of more
    68(a)   99C4   --
    worm
    (Caenorhabditis elegans)
    Secernentea rps-81 , 3 40S ribosomal protein S83
    Protein RPS-81
    68(a)3
    62.5(n)1
    68.27(a)1
      IV(7313232-7314047)3
    1775031  NM_068766.31  NP_501167.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPS8A6
    RPS8B6
    Protein component of the small (40S) ribosomal sub...
    Protein component of the small (40S) ribosomal sub...
    63(a)
    63(a)
    many → 1
    many → 1
    II(88523-89125)
    V(363100-363702)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G592401 40S ribosomal protein S8-2 58.29(n)
    64.53(a)
      836042  NM_125314.4  NP_200732.2 
    rice
    (Oryza sativa)
    Liliopsida Os.115412 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.66(n)    AK068316.1 


    ENSEMBL Gene Tree for RPS8 (if available)
    TreeFam Gene Tree for RPS8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPS8 gene

    RPS8 for paralogs           About GeneDecksing


    5/11 Pseudogenes.org Pseudogenes for RPS8 (see all 11)
    PGOHUM00000238939 PGOHUM00000247870 PGOHUM00000247915 PGOHUM00000246647 PGOHUM00000234934


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/11 SNPs in RPS8 are shown (see all 11)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0518614
    ----see VAR_0518612 R G mis40--------
    rs1911880711,2
    --45239458(+) GTGAAA/CCCCCA 1 -- us2k10--------
    rs1490572631,2
    --45239494(+) CCAAGA/CATGGT 1 -- us2k10--------
    rs104658181,2
    C,F,A,H--45244692(+) TTCAGT/CAATAT 1 -- ds500133Minor allele frequency- C:0.45NS EA NA WA CSA 3062
    rs1488651161,2
    --45244759(+) AGGATA/CTTGTA 1 -- ds50010--------
    rs1910542601,2
    --45244769(+) ACCCAC/TTGTAA 1 -- ds50010--------
    rs1832899411,2
    --45244788(+) GTGATA/TTCTGC 1 -- ds50010--------
    rs2005750611,2
    C--45244824(+) CTTTG-/ACTTAA
            
    ACTTG
    1 -- ds50010--------
    rs2013042241,2
    ----45244901(+) TTTTTC/TTTTTT 1 -- ds50010--------
    rs1129660031,2
    ----45244887(+) TTGGA-/TTTTTT 1 -- ds50011Minor allele frequency- T:0.00CSA 2

    HapMap Linkage Disequilibrium report for RPS8 (45240923 - 45244451 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RPS8:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv870815CNV Loss21882294
    nsv461406CNV Loss19166990

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RPS8
    DNA2.0 Custom Variant and Variant Library Synthesis for RPS8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600357    OMIM disorders: --

    6 diseases for RPS8:    About MalaCards
    colonic polyps    influenza    colorectal cancer    prostate cancer
    prostatitis    breast cancer


    RPS8 for disorders           About GeneDecksing


    Export disorders for RPS8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPS8 gene, integrated from 9 sources (see all 74):
    (articles sorted by number of sources associating them with RPS8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The structure of the human intron-containing S8 ribosomal protein gene and determination of its chromosomal location at 1p32-p34.1. (PubMed id 8432552)1, 2, 3, 9 Davies B. and Fried M. (1993)
    2. Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)1, 2 Joeson L.... Nielsen F.C. (2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699)1, 2 Vladimirov S.N.... Otto A. (1996)
    5. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....Yanez-Mo M. (2013)
    6. Structures of the human and Drosophila 80S ribosome. (PubMed id 23636399)2 Anger A.M.... Beckmann R. (2013)
    7. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    8. Deubiquitinase FAM/USP9X interacts with the E3 ubiquit in ligase SMURF1 protein and protects it from ligase activity-dependent self-deg radation. (PubMed id 23184937)1 Xie Y....Cong F. (2013)
    9. Localization and identification of sumoylated proteins in human sperm: excessive sumoylation is a marker of defective spermatozoa. (PubMed id 23077236)1 Vigodner M....Callaway M. (2013)
    10. A Proteomics Strategy for the Identification of FAT10- Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6202 HGNC: 10441 AceView: RPS8 Ensembl:ENSG00000142937 euGenes: HUgn6202
    ECgene: RPS8 Kegg: 6202 H-InvDB: RPS8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPS8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RPS8 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RPS8 gene:
    Search GeneIP for patents involving RPS8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for RPS8  
     OriGene qPCR primer pairs and template standards for RPS8   OriGene Protein Over-expression Lysate for RPS8  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for RPS8  
     OriGene qSTAR qPCR primer pairs in human, mouse for RPS8   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for RPS8   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RPS8   OriGene Custom Protein Services for RPS8  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RPS8
     QIAGEN SeqTarget long-range PCR primers for resequencing RPS8
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS8
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS8
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS8
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS8
     GenScript Custom Purified and Recombinant Proteins Services for RPS8 GenScript cDNA clones with any tag delivered in your preferred vector for RPS8
     GenScript Custom Assay Services for RPS8 GenScript Custom Superior Antibodies Services for RPS8
     GenScript Custom overexpressing Cell Line Services for RPS8 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RPS8 promoter
     Search Chromatin IP Primers for RPS8
     RT2 qPCR Primer Assay in human, mouse, rat RPS8
     Search GNC Networks for RPS8
     SABiosciences Custom PCR Arrays for RPS8
     Search Tocris compounds for RPS8 (RS8)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RPS8 antibodies
     RPS8 proteins
     Antibodies for RPS8
     See all of Abcam's Antibodies, Kits and Proteins for RPS8
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for RPS8
     Antibodies for RPS8
     ELISAs for RPS8
     CLIAs for RPS8
     Search LifeMap BioReagents cell lines for RPS8
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS8
     Browse SwitchGear 3'UTR luciferase reporter plasmids for RPS8
     SwitchGear Promoter luciferase reporter plasmids for RPS8
     ThermoFisher Antibodies for RPS8
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS8
     inGenious Targeting Laboratory - Custom generated mouse model solutions for RPS8
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RPS8
    Customized:
     lentivirus for stable overexpression of RPS8
     lentivirus expression plasmids for stable overexpression of RPS8
     adenovirus for overexpression of RPS8
     LSBio Antibodies in human, mouse, rat for RPS8
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RPS8 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4