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Aliases for RPS8 Gene

Aliases for RPS8 Gene

  • Ribosomal Protein S8 2 3 5
  • OK/SW-Cl.83 3
  • S8 3

External Ids for RPS8 Gene

Previous GeneCards Identifiers for RPS8 Gene

  • GC01P044968
  • GC01P044241
  • GC01P044671
  • GC01P044654
  • GC01P044914
  • GC01P044915
  • GC01P044918
  • GC01P044927
  • GC01P045013
  • GC01P045240

Summaries for RPS8 Gene

Entrez Gene Summary for RPS8 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S8E family of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal tumors and colon polyps compared to matched normal colonic mucosa has been observed. This gene is co-transcribed with the small nucleolar RNA genes U38A, U38B, U39, and U40, which are located in its fourth, fifth, first, and second introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS8 Gene

RPS8 (Ribosomal Protein S8) is a Protein Coding gene. Diseases associated with RPS8 include Giant Axonal Neuropathy. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPS8 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS8 Gene

Genomics for RPS8 Gene

Regulatory Elements for RPS8 Gene

Enhancers for RPS8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPS8 on UCSC Golden Path with GeneCards custom track

Promoters for RPS8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPS8 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPS8 Gene

44,775,251 bp from pter
44,778,779 bp from pter
3,529 bases
Plus strand

Genomic View for RPS8 Gene

Genes around RPS8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS8 Gene

Proteins for RPS8 Gene

  • Protein details for RPS8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    40S ribosomal protein S8
    Protein Accession:
    Secondary Accessions:
    • P09058
    • Q6IRL7

    Protein attributes for RPS8 Gene

    208 amino acids
    Molecular mass:
    24205 Da
    Quaternary structure:
    • Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.

    Three dimensional structures from OCA and Proteopedia for RPS8 Gene

neXtProt entry for RPS8 Gene

Proteomics data for RPS8 Gene at MOPED

Post-translational modifications for RPS8 Gene

  • Ubiquitination at Lys 37, Lys 98, Lys 170, and Lys 193
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPS8 Gene

Domains & Families for RPS8 Gene

Gene Families for RPS8 Gene

Protein Domains for RPS8 Gene

Suggested Antigen Peptide Sequences for RPS8 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein S8e family.
  • Belongs to the ribosomal protein S8e family.
genes like me logo Genes that share domains with RPS8: view

Function for RPS8 Gene

Molecular function for RPS8 Gene

GENATLAS Biochemistry:
40S ribosomal protein S8,24kDa
genes like me logo Genes that share phenotypes with RPS8: view

Transcription Factor Targets for RPS8 Gene

Selected GeneGlobe predicted Target genes for RPS8

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models and HOMER Transcription for RPS8 Gene

Localization for RPS8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS8 Gene

Cytoplasm. Membrane; Lipid-anchor. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Subcellular locations from

Jensen Localization Image for RPS8 Gene COMPARTMENTS Subcellular localization image for RPS8 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
chloroplast 2

Gene Ontology (GO) - Cellular Components for RPS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with RPS8: view

Pathways & Interactions for RPS8 Gene

SuperPathways for RPS8 Gene

Superpath Contained pathways
1 Viral mRNA Translation
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 Infectious disease
5 rRNA processing
genes like me logo Genes that share pathways with RPS8: view

Gene Ontology (GO) - Biological Process for RPS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS --
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
GO:0016032 viral process TAS --
GO:0019058 viral life cycle TAS --
genes like me logo Genes that share ontologies with RPS8: view

No data available for SIGNOR curated interactions for RPS8 Gene

Drugs & Compounds for RPS8 Gene

No Compound Related Data Available

Transcripts for RPS8 Gene

Unigene Clusters for RPS8 Gene

Ribosomal protein S8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPS8 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c ^ 8
SP1: - - - - - - -
SP2: - - - - -
SP3: - -
SP4: - - -
SP5: - -
SP6: - - -
SP7: -

Relevant External Links for RPS8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS8 Gene

mRNA expression in normal human tissues for RPS8 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS8 Gene

SOURCE GeneReport for Unigene cluster for RPS8 Gene Hs.512675

genes like me logo Genes that share expression patterns with RPS8: view

Protein tissue co-expression partners for RPS8 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS8 Gene

Orthologs for RPS8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPS8 35
  • 91.67 (n)
  • 100 (a)
RPS8 36
  • 100 (a)
(Canis familiaris)
Mammalia RPS8 35
  • 90.54 (n)
  • 100 (a)
-- 36
  • 100 (a)
(Mus musculus)
Mammalia Rps8 35
  • 90.06 (n)
  • 100 (a)
Rps8 16
Rps8 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rps8 35
  • 90.71 (n)
  • 100 (a)
(Monodelphis domestica)
Mammalia RPS8 36
  • 78 (a)
(Pan troglodytes)
Mammalia RPS8 36
  • 100 (a)
(Gallus gallus)
Aves RPS8 35
  • 83.17 (n)
  • 97.6 (a)
RPS8 36
  • 98 (a)
(Anolis carolinensis)
Reptilia RPS8 36
  • 98 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rps8 35
  • 80.13 (n)
  • 95.67 (a)
(Danio rerio)
Actinopterygii -- 35
rps8b 35
  • 78.04 (n)
  • 91.83 (a)
rps8b 36
  • 92 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4092 35
fruit fly
(Drosophila melanogaster)
Insecta CG7808 37
  • 68 (a)
RpS8 35
  • 67.48 (n)
  • 70.39 (a)
RpS8 36
  • 70 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002437 35
  • 66.02 (n)
  • 71.36 (a)
(Caenorhabditis elegans)
Secernentea rps-8 37
  • 68 (a)
rps-8 35
  • 62.5 (n)
  • 68.27 (a)
rps-8 36
  • 68 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR375W 35
  • 60.33 (n)
  • 61.5 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E20461g 35
  • 57.38 (n)
  • 61.69 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS8A 35
  • 57 (n)
  • 62.5 (a)
RPS8A 36
  • 62 (a)
RPS8B 36
  • 62 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G59240 35
  • 58.62 (n)
  • 64.04 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.11572 35
(Oryza sativa)
Liliopsida Os.11541 35
(Zea mays)
Liliopsida Zm.7012 35
bread mold
(Neurospora crassa)
Ascomycetes NCU08500 35
  • 59.63 (n)
  • 60.8 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps801 35
  • 56.45 (n)
  • 60.3 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5224 36
  • 62 (a)
Species with no ortholog for RPS8:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS8 Gene

Gene Tree for RPS8 (if available)
Gene Tree for RPS8 (if available)

Paralogs for RPS8 Gene

genes like me logo Genes that share paralogs with RPS8: view

No data available for Paralogs for RPS8 Gene

Variants for RPS8 Gene

Sequence variations from dbSNP and Humsavar for RPS8 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_051861 -
rs10465818 -- 44,779,020(+) TTCAG(C/T)AATAT downstream-variant-500B
rs112966003 -- 44,779,215(+) TTGGA(-/T)TTTTT downstream-variant-500B
rs143287984 -- 44,779,130(+) GCTTG(A/G)TCTCC downstream-variant-500B
rs183289941 -- 44,779,116(+) GTGAT(A/T)TCTGC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RPS8 Gene

Variant ID Type Subtype PubMed ID
nsv461406 CNV Loss 19166990
nsv870815 CNV Loss 21882294

Variation tolerance for RPS8 Gene

Residual Variation Intolerance Score: 30.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 0.84% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RPS8 Gene

Disorders for RPS8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPS8 Gene - From: GeneCards

Disorder Aliases PubMed IDs
giant axonal neuropathy
  • gan
- elite association - COSMIC cancer census association via MalaCards
Search RPS8 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RPS8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RPS8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS8 Gene

Publications for RPS8 Gene

  1. The structure of the human intron-containing S8 ribosomal protein gene and determination of its chromosomal location at 1p32-p34.1. (PMID: 8432552) Davies B. … Fried M. (Genomics 1993) 2 3 4 23 67
  2. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for RPS8 Gene

Sources for RPS8 Gene