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RPS8 Gene

protein-coding   GIFtS: 60
GCID: GC01P045240

Ribosomal Protein S8

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribosomal Protein S81 2
40S Ribosomal Protein S82
OK/SW-cl.832
S82

External Ids:    HGNC: 104411   Entrez Gene: 62022   Ensembl: ENSG000001429377   OMIM: 6003575   UniProtKB: P622413   

Export aliases for RPS8 gene to outside databases

Previous GC identifers: GC01P044968 GC01P044241 GC01P044671 GC01P044654 GC01P044914 GC01P044915 GC01P044918 GC01P044927 GC01P045013


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RPS8 Gene:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This
gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S8E family of
ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal tumors and
colon polyps compared to matched normal colonic mucosa has been observed. This gene is co-transcribed with the
small nucleolar RNA genes U38A, U38B, U39, and U40, which are located in its fourth, fifth, first, and second
introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed
pseudogenes of this gene dispersed through the genome. (provided by RefSeq, Jul 2008)

GeneCards Summary for RPS8 Gene:
RPS8 (ribosomal protein S8) is a protein-coding gene. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for RPS8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPS8 gene promoter:
         AP-1   SRF (504 AA)   ATF-2   Nkx2-5   RelA   Gfi-1   E47   Hand1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPS8 promoter sequence
   Search Chromatin IP Primers for RPS8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPS8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.1-p32   Ensembl cytogenetic band:  1p34.1   HGNC cytogenetic band: 1p34.1-p32

RPS8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS8 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P045240:  view genomic region     (about GC identifiers)

Start:
45,240,923 bp from pter      End:
45,244,451 bp from pter
Size:
3,529 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RS8_HUMAN, P62241 (See protein sequence)
Recommended Name: 40S ribosomal protein S8  
Size: 208 amino acids; 24205 Da
Subunit: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs
1 PDB 3D structure from and Proteopedia for RPS8:
3J3A (3D)    
Secondary accessions: P09058 Q6IRL7

Explore the universe of human proteins at neXtProt for RPS8: NX_P62241

Explore proteomics data for RPS8 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys37, Lys98, Lys157, Lys170, Lys193
  • Modification sites at PhosphoSitePlus

  • See RPS8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001003.1  
    ENSEMBL proteins: 
     ENSP00000379888   ENSP00000361283  
    Reactome Protein details: P62241

    RPS8 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for RPS8

     
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    antibodies-online proteins for RPS8 (13 products) 

     
    antibodies-online peptides for RPS8

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RPS: S ribosomal proteins

    3 InterPro protein domains:
     IPR001047 Ribosomal_S8e
     IPR018283 Ribosomal_S8e_CS
     IPR022309 Ribosomal_S8e/biogenesis_NSA2

    Graphical View of Domain Structure for InterPro Entry P62241

    ProtoNet protein and cluster: P62241

    UniProtKB/Swiss-Prot: RS8_HUMAN, P62241
    Similarity: Belongs to the ribosomal protein S8e family


    Find genes that share domains with RPS8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for RPS8:
    40S ribosomal protein S8,24kDa

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome IBA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with RPS8           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for RPS8:
     Decreased Hepatitis C virus re  Decreased cell number, increas  Decreased viability  Decreased viability of wild-ty 
     Nucleolar pre-40S maturation d  S arrest 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RPS8
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RPS8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RPS8

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for RPS8 (see all 604):
    ABCD3,  ACVR1C,  ACVR2A,  ADAMTS2,  ADAMTSL2,  ADH4,  ADH5,  ADNP2,  AFF2,  AGAP11

    miRNA
    Products:
        
    miRTarBase miRNAs that target RPS8:
    hsa-mir-92a-3p (MIRT049836), hsa-mir-3615 (MIRT052854), hsa-mir-181a-5p (MIRT047305), hsa-mir-30e-5p (MIRT044141), hsa-mir-1250-5p (MIRT035861), hsa-mir-1303 (MIRT035875), hsa-mir-10b-5p (MIRT047461), hsa-mir-324-3p (MIRT042985), hsa-mir-181b-5p (MIRT047293), hsa-mir-100-5p (MIRT048422)

    Block miRNA regulation of human, mouse, rat RPS8 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate RPS8:
    hsa-miR-556-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RPS8

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for RPS8
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    GenScript: all cDNA clones in your preferred vector: RPS8 (NM_001012)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPS8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS8

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RS8_HUMAN, P62241: Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    chloroplast2
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005840ribosome ----
    GO:0022627cytosolic small ribosomal subunit TAS8432552

    Find genes that share ontologies with RPS8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RPS8 About   (see all 6)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CFTR translational fidelity class I mutations
    CFTR translational fidelity class I mutations 0.60
    Ribosome0.54
    Cytoplasmic Ribosomal Proteins0.60
    2Influenza Viral RNA Transcription and Replication
    Viral mRNA Translation0.94
    Eukaryotic Translation Initiation0.89
    Peptide chain elongation0.94
    Cap-dependent Translation Initiation0.89
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    Formation of a pool of free 40S subunits0.94
    Nonsense-Mediated Decay0.89
    3Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
    Translation initiation complex formation0.91
    Ribosomal scanning and start codon recognition0.91
    Formation of the ternary complex, and subsequently, the 43S complex0.91
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.90
    4Gene Expression
    Gene Expression0.40
    5Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30


    Find genes that share SuperPaths with RPS8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPS8
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPS8
        Cytoplasmic Ribosomal Proteins

    Selected Reactome Pathways for RPS8 (see all 12)
        Peptide chain elongation
    Formation of the ternary complex, and subsequently, the 43S complex
    Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
    Viral mRNA Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit


    1 Kegg Pathway  (Kegg details for RPS8):
        Ribosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RPS8
    Interactions:

        Search GeneGlobe Interaction Network for RPS8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPS8 (P622411, 2, 3 ENSP000003798884) via UniProtKB, MINT, STRING, and/or I2D (see all 621)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=2 
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    HIST1H4EP628053I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0000462maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--

    Find genes that share ontologies with RPS8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPS8 (RS8)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RPS8 gene: 
    NM_001012.1  

    Unigene Cluster for RPS8:

    Ribosomal protein S8
    Hs.512675  [show with all ESTs]
    Unigene Representative Sequence: BG033629
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000497035 ENST00000396651(uc001cmi.3) ENST00000372209 ENST00000470475
    ENST00000485390 ENST00000464658 ENST00000484599 ENST00000474582
    miRNA
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    Block miRNA regulation of human, mouse, rat RPS8 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate RPS8:
    hsa-miR-556-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: RPS8 (NM_001012)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat RPS8
      QuantiFast Probe-based Assays in human, mouse, rat RPS8

    Additional mRNA sequence: 

    AB062401.1 AF116700.1 AK311854.1 BC005678.1 BC022070.1 BC070875.1 

    Selected DOTS entries (see all 104):

    DT.91653431  DT.97867907  DT.91889352  DT.91975620  DT.85102408  DT.121388170  DT.95145235  DT.100726298 
    DT.91999339  DT.91894031  DT.95083095  DT.95258454  DT.121388318  DT.91828949  DT.99985027  DT.97857401 
    DT.91697190  DT.121388242  DT.100726305  DT.100726322  DT.100836107  DT.121388223  DT.100726295  DT.121388222 

    Selected AceView cDNA sequences (see all 485):

    AW517178 AA775100 AA515804 AA302243 AA486247 BU940618 AW630832 BM313439 
    CF130977 BC005678 AI421015 AA148112 AA593707 AW245168 BQ643145 AW162244 
    BU150483 BI467288 AA314758 CD511459 BQ066819 AA156004 AI582972 BQ941037 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RPS8 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c ^ 8
    SP1:        -     -     -     -     -                       -     -                                 
    SP2:                    -     -     -                       -     -                                 
    SP3:                                                        -     -                                 
    SP4:                                                  -     -     -                                 
    SP5:                                                        -     -                                 


    ECgene alternative splicing isoforms for RPS8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RPS8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATAAAGGT
    RPS8 Expression
    About this image

    RPS8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPS8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.512675
        Custom PCR Arrays for RPS8
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat RPS8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPS8 gene from Selected species (see all 28)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rps81 , 5 ribosomal protein S81, 5 90.06(n)1
    100(a)1
      4 (53.41 cM)5
    201161  NM_009098.21  NP_033124.11 
     1171538275 
    chicken
    (Gallus gallus)
    Aves RPS81 ribosomal protein S8 83.17(n)
    97.6(a)
      424584  NM_001252126.1  NP_001239055.1 
    lizard
    (Anolis carolinensis)
    Reptilia RPS86
    ribosomal protein S8
    98(a)
    1 ↔ 1
    4(111055199-111061900)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX847483.12   -- 91.44(n)    BX847483.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BI476728.12   -- 79.94(n)   326946  BI476728.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG78083
    RpS81
    protein biosynthesis structural
    constituent of more3
    Ribosomal protein S81
    68(a)3
    67.48(n)1
    70.39(a)1
      99C43
    435321  NM_001260433.21  NP_001247362.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rps-81 , 3 40S ribosomal protein S83
    rps-81
    68(a)3
    62.5(n)1
    68.27(a)1
      IV(7313232-7314047)3
    1775031  NM_068766.41  NP_501167.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPS8A1 RPS8A 57(n)
    62.5(a)
      852206   NP_009481.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G592401 AT5G59240 58.62(n)
    64.04(a)
      836042  NM_125314.4  NP_200732.2 
    rice
    (Oryza sativa)
    Liliopsida Os.115412 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.66(n)    AK068316.1 


    ENSEMBL Gene Tree for RPS8 (if available)
    TreeFam Gene Tree for RPS8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RPS8 gene

    Find genes that share paralogs with RPS8           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for RPS8 (see all 11)
    PGOHUM00000238939 PGOHUM00000247870 PGOHUM00000247915 PGOHUM00000246647 PGOHUM00000234934


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RPS8 (see all 11)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1911880711,2
    --45239458(+) GTGAAA/CCCCCA 1 -- us2k10--------
    rs1490572631,2
    --45239494(+) CCAAGA/CATGGT 1 -- us2k10--------
    rs104658181,2
    C,F,A,H--45244692(+) TTCAGT/CAATAT 1 -- ds500133Minor allele frequency- C:0.45NS EA NA WA CSA 3062
    rs1488651161,2
    --45244759(+) AGGATA/CTTGTA 1 -- ds50010--------
    rs1910542601,2
    --45244769(+) ACCCAC/TTGTAA 1 -- ds50010--------
    rs1832899411,2
    --45244788(+) GTGATA/TTCTGC 1 -- ds50010--------
    rs2005750611,2
    C--45244824(+) CTTTG-/ACTTAA
            
    ACTTG
    1 -- ds50010--------
    rs115378701,2,4
    ----see VAR_0518612 mis40--------
    rs2013042241,2
    ----45244901(+) TTTTTC/TTTTTT 1 -- ds50010--------
    rs1129660031,2
    ----45244887(+) TTGGA-/TTTTTT 1 -- ds50011Minor allele frequency- T:0.00CSA 2

    HapMap Linkage Disequilibrium report for RPS8 (45240923 - 45244451 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RPS8:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv870815CNV Loss21882294
    nsv461406CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RPS8
    DNA2.0 Custom Variant and Variant Library Synthesis for RPS8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600357    OMIM disorders: --


    Find genes that share disorders with RPS8           About GenesLikeMe


    Export disorders for RPS8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RPS8 gene, integrated from 10 sources (see all 76):
    (articles sorted by number of sources associating them with RPS8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The structure of the human intron-containing S8 ribosomal protein gene and determination of its chromosomal location at 1p32-p34.1. (PubMed id 8432552)1, 2, 3, 9 Davies B. and Fried M. (Genomics 1993)
    2. Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)1, 2 Joeson L.... Nielsen F.C. (Mol. Cell. Proteomics 2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699)1, 2 Vladimirov S.N.... Otto A. (Eur. J. Biochem. 1996)
    5. Poly(ADP-ribose) polymerase-1 modulates Nrf2-dependent transcription. (PubMed id 24140708)1 Wu T....Zhang D.D. (amp 2014)
    6. A Proteomics Strategy for the Identification of FAT10-Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (J. Proteome Res. 2014)
    7. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)
    8. Structures of the human and Drosophila 80S ribosome. (PubMed id 23636399)2 Anger A.M.... Beckmann R. (Nature 2013)
    9. Profiling of Parkin-binding partners using tandem affinity purification. (PubMed id 24244333)1 Zanon A....Pichler I. (PLoS ONE 2013)
    10. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6202 HGNC: 10441 AceView: RPS8 Ensembl:ENSG00000142937 euGenes: HUgn6202
    ECgene: RPS8 Kegg: 6202 H-InvDB: RPS8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RPS8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RPS8 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RPS8 gene:
    Search GeneIP for patents involving RPS8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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