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Aliases for RPS8 Gene

Aliases for RPS8 Gene

  • Ribosomal Protein S8 2 3 5
  • 40S Ribosomal Protein S8 3
  • OK/SW-Cl.83 3
  • S8 3

External Ids for RPS8 Gene

Previous GeneCards Identifiers for RPS8 Gene

  • GC01P044968
  • GC01P044241
  • GC01P044671
  • GC01P044654
  • GC01P044914
  • GC01P044915
  • GC01P044918
  • GC01P044927
  • GC01P045013
  • GC01P045240

Summaries for RPS8 Gene

Entrez Gene Summary for RPS8 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S8E family of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal tumors and colon polyps compared to matched normal colonic mucosa has been observed. This gene is co-transcribed with the small nucleolar RNA genes U38A, U38B, U39, and U40, which are located in its fourth, fifth, first, and second introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS8 Gene

RPS8 (Ribosomal Protein S8) is a Protein Coding gene. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Metabolism. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPS8 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS8 Gene

Genomics for RPS8 Gene

Regulatory Elements for RPS8 Gene

Enhancers for RPS8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F044729 1.1 ENCODE 32.3 -43.9 -43878 2.8 CREB3L1 YBX1 FEZF1 YY1 ZNF143 SP3 NFYC TBX21 MEF2D ZNF610 GPBP1L1 TOE1 RPS8 RPL7AP16 DMAP1 RPS15AP10 TMEM69 ZSWIM5 UROD BEST4
GH01F045684 0.6 ENCODE 31.5 +911.8 911760 5.1 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC RPS8 TOE1 MAST2 ZSWIM5 GPBP1L1 RPL7AP16 PTCH2 RPS15AP10 BTBD19 IPP
GH01F044774 0.4 ENCODE 29.5 +1.0 968 3.7 CREB3L1 ZFP64 YBX1 DMAP1 YY1 ZNF143 MCM3 SP3 NFYC TBX21 DMAP1 TOE1 GPBP1L1 ZSWIM5 RPS8 RPL7AP16 RPS15AP10 LOC101929609 TMEM69 UROD
GH01F044212 0.4 ENCODE 27.9 -561.8 -561769 2.3 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 SP3 SZT2 DMAP1 RPS8 KDM4A LOC105378687 LOC101929609 KDM4A-AS1 BTBD19 ERI3 GC01P044238
GH01F044717 0.8 Ensembl ENCODE 27.8 -53.7 -53651 8.0 CREB3L1 MLX ZFP64 YBX1 FEZF1 ZNF143 SP3 NFYC TBX21 MEF2D GPBP1L1 TOE1 RPS8 RPL7AP16 DMAP1 BTBD19 RPS15AP10 TMEM69 RPS15AP11 SNORD38B
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RPS8 on UCSC Golden Path with GeneCards custom track

Promoters for RPS8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000535786 549 2401 CREB3L1 ZFP64 YBX1 DMAP1 YY1 ZNF143 SP3 NFYC TBX21 MEF2D

Genomic Location for RPS8 Gene

Chromosome:
1
Start:
44,775,251 bp from pter
End:
44,778,779 bp from pter
Size:
3,529 bases
Orientation:
Plus strand

Genomic View for RPS8 Gene

Genes around RPS8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS8 Gene

Proteins for RPS8 Gene

  • Protein details for RPS8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62241-RS8_HUMAN
    Recommended name:
    40S ribosomal protein S8
    Protein Accession:
    P62241
    Secondary Accessions:
    • P09058
    • Q6IRL7

    Protein attributes for RPS8 Gene

    Size:
    208 amino acids
    Molecular mass:
    24205 Da
    Quaternary structure:
    • Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.

    Three dimensional structures from OCA and Proteopedia for RPS8 Gene

neXtProt entry for RPS8 Gene

Post-translational modifications for RPS8 Gene

  • Ubiquitination at Lys 37, Lys 98, Lys 170, and Lys 193
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPS8 Gene

Domains & Families for RPS8 Gene

Gene Families for RPS8 Gene

Protein Domains for RPS8 Gene

Suggested Antigen Peptide Sequences for RPS8 Gene

Graphical View of Domain Structure for InterPro Entry

P62241

UniProtKB/Swiss-Prot:

RS8_HUMAN :
  • Belongs to the ribosomal protein S8e family.
Family:
  • Belongs to the ribosomal protein S8e family.
genes like me logo Genes that share domains with RPS8: view

Function for RPS8 Gene

Molecular function for RPS8 Gene

GENATLAS Biochemistry:
40S ribosomal protein S8,24kDa

Gene Ontology (GO) - Molecular Function for RPS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA,IBA --
GO:0005515 protein binding IPI --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPS8: view
genes like me logo Genes that share phenotypes with RPS8: view

Animal Model Products

Transcription Factor Targets for RPS8 Gene

Selected GeneGlobe predicted Target genes for RPS8

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and HOMER Transcription for RPS8 Gene

Localization for RPS8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS8 Gene

Cytoplasm. Membrane; Lipid-anchor. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS8 Gene COMPARTMENTS Subcellular localization image for RPS8 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
chloroplast 2

Gene Ontology (GO) - Cellular Components for RPS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RPS8: view

Pathways & Interactions for RPS8 Gene

SuperPathways for RPS8 Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
.55
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing in the nucleus and cytosol
5 HIV Life Cycle
.45
genes like me logo Genes that share pathways with RPS8: view

Gene Ontology (GO) - Biological Process for RPS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,NAS 8432552
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPS8: view

No data available for SIGNOR curated interactions for RPS8 Gene

Transcripts for RPS8 Gene

Unigene Clusters for RPS8 Gene

Ribosomal protein S8:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS8 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c ^ 8
SP1: - - - - - - -
SP2: - - - - -
SP3: - -
SP4: - - -
SP5: - -
SP6: - - -
SP7: -
SP8:

Relevant External Links for RPS8 Gene

GeneLoc Exon Structure for
RPS8
ECgene alternative splicing isoforms for
RPS8

Expression for RPS8 Gene

mRNA expression in normal human tissues for RPS8 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPS8 Gene



Protein tissue co-expression partners for RPS8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS8 Gene:

RPS8

SOURCE GeneReport for Unigene cluster for RPS8 Gene:

Hs.512675
genes like me logo Genes that share expression patterns with RPS8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS8 Gene

Orthologs for RPS8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS8 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 35
  • 100 (a)
OneToMany
RPS8 34
  • 90.54 (n)
chimpanzee
(Pan troglodytes)
Mammalia RPS8 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RPS8 34 35
  • 91.67 (n)
rat
(Rattus norvegicus)
Mammalia Rps8 34
  • 90.71 (n)
mouse
(Mus musculus)
Mammalia Rps8 34 16 35
  • 90.06 (n)
oppossum
(Monodelphis domestica)
Mammalia RPS8 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPS8 34 35
  • 83.17 (n)
lizard
(Anolis carolinensis)
Reptilia RPS8 35
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rps8 34
  • 80.13 (n)
zebrafish
(Danio rerio)
Actinopterygii rps8b 34 35
  • 78.04 (n)
-- 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4092 34
fruit fly
(Drosophila melanogaster)
Insecta CG7808 36
  • 68 (a)
RpS8 34 35
  • 67.48 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002437 34
  • 66.02 (n)
worm
(Caenorhabditis elegans)
Secernentea rps-8 36 34 35
  • 62.5 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS8B 35
  • 62 (a)
OneToMany
RPS8A 34 35
  • 57 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR375W 34
  • 60.33 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E20461g 34
  • 57.38 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G59240 34
  • 58.62 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.11572 34
rice
(Oryza sativa)
Liliopsida Os.11541 34
corn
(Zea mays)
Liliopsida Zm.7012 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5224 35
  • 62 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU08500 34
  • 59.63 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps801 34
  • 56.45 (n)
Species where no ortholog for RPS8 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS8 Gene

ENSEMBL:
Gene Tree for RPS8 (if available)
TreeFam:
Gene Tree for RPS8 (if available)

Paralogs for RPS8 Gene

No data available for Paralogs for RPS8 Gene

Variants for RPS8 Gene

Sequence variations from dbSNP and Humsavar for RPS8 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10465818 -- 44,779,020(+) TTCAG(C/T)AATAT downstream-variant-500B
rs1061669 -- 44,778,638(+) GCAAA(A/G)AGTTG downstream-variant-500B, reference, missense
rs1061674 -- 44,778,653(+) TCTAT(C/G/T)TTAGG downstream-variant-500B, reference, missense
rs111303820 -- 44,774,508(+) GCGCC(C/G)GCCAC upstream-variant-2KB
rs11211031 -- 44,775,441(+) CCTCC(C/T)AGGCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPS8 Gene

Variant ID Type Subtype PubMed ID
nsv461406 CNV loss 19166990
nsv546145 CNV loss 21841781
nsv945912 CNV duplication 23825009
nsv998871 CNV loss 25217958

Variation tolerance for RPS8 Gene

Residual Variation Intolerance Score: 30.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 0.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPS8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS8 Gene

Disorders for RPS8 Gene

Relevant External Links for RPS8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPS8

No disorders were found for RPS8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPS8 Gene

Publications for RPS8 Gene

  1. The structure of the human intron-containing S8 ribosomal protein gene and determination of its chromosomal location at 1p32-p34.1. (PMID: 8432552) Davies B. … Fried M. (Genomics 1993) 2 3 4 22 64
  2. Molecular composition of IMP1 ribonucleoprotein granules. (PMID: 17289661) Joeson L. … Nielsen F.C. (Mol. Cell. Proteomics 2007) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PMID: 8706699) Vladimirov S.N. … Otto A. (Eur. J. Biochem. 1996) 3 4 64
  5. The scaffold protein KSR1, a novel therapeutic target for the treatment of Merlin-deficient tumors. (PMID: 26549023) Zhou L. … Hanemann C.O. (Oncogene 2016) 3 64

Products for RPS8 Gene

Sources for RPS8 Gene

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