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Aliases for RPS7 Gene

Aliases for RPS7 Gene

  • Ribosomal Protein S7 2 3 5
  • DBA8 3
  • S7 3

External Ids for RPS7 Gene

Previous GeneCards Identifiers for RPS7 Gene

  • GC02P003100
  • GC02P003265
  • GC02P003187
  • GC02P003116
  • GC02P003600
  • GC02P003622
  • GC02P003564

Summaries for RPS7 Gene

Entrez Gene Summary for RPS7 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS7 Gene

RPS7 (Ribosomal Protein S7) is a Protein Coding gene. Diseases associated with RPS7 include Diamond-Blackfan Anemia 8 and Diamond-Blackfan Anemia. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPS7 Gene

  • Required for rRNA maturation.

Gene Wiki entry for RPS7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS7 Gene

Genomics for RPS7 Gene

Regulatory Elements for RPS7 Gene

Enhancers for RPS7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPS7 on UCSC Golden Path with GeneCards custom track

Promoters for RPS7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPS7 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPS7 Gene

3,575,205 bp from pter
3,580,919 bp from pter
5,715 bases
Plus strand

Genomic View for RPS7 Gene

Genes around RPS7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS7 Gene

Proteins for RPS7 Gene

  • Protein details for RPS7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    40S ribosomal protein S7
    Protein Accession:
    Secondary Accessions:
    • P23821
    • P24818
    • Q57Z92
    • Q6IPH1

    Protein attributes for RPS7 Gene

    194 amino acids
    Molecular mass:
    22127 Da
    Quaternary structure:
    • Binds IPO9 with high affinity. Interacts with NEK6.

    Three dimensional structures from OCA and Proteopedia for RPS7 Gene

neXtProt entry for RPS7 Gene

Proteomics data for RPS7 Gene at MOPED

Post-translational modifications for RPS7 Gene

  • Phosphorylated by NEK6.
  • Ubiquitination at Lys 15, Lys 49, Lys 74, Lys 85, Lys 90, Lys 142, Lys 179, and Lys 183
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS7 Gene

No data available for DME Specific Peptides for RPS7 Gene

Domains & Families for RPS7 Gene

Gene Families for RPS7 Gene

Protein Domains for RPS7 Gene


Suggested Antigen Peptide Sequences for RPS7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein S7e family.
  • Belongs to the ribosomal protein S7e family.
genes like me logo Genes that share domains with RPS7: view

Function for RPS7 Gene

Molecular function for RPS7 Gene

GENATLAS Biochemistry:
40S ribosomal protein S7,22kDa
UniProtKB/Swiss-Prot Function:
Required for rRNA maturation.
genes like me logo Genes that share phenotypes with RPS7: view

Human Phenotype Ontology for RPS7 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS7 Gene

Localization for RPS7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS7 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with NEK6 in the centrosome.

Subcellular locations from

Jensen Localization Image for RPS7 Gene COMPARTMENTS Subcellular localization image for RPS7 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
cytoskeleton 3
chloroplast 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA 11823430
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA,IDA 15883184
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with RPS7: view

Pathways & Interactions for RPS7 Gene

SuperPathways for RPS7 Gene

Superpath Contained pathways
1 Viral mRNA Translation
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing
5 Infectious disease
genes like me logo Genes that share pathways with RPS7: view

Gene Ontology (GO) - Biological Process for RPS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing IMP,TAS --
GO:0006413 translational initiation TAS --
GO:0016032 viral process TAS --
GO:0019058 viral life cycle TAS --
GO:0019083 viral transcription TAS --
genes like me logo Genes that share ontologies with RPS7: view

No data available for SIGNOR curated interactions for RPS7 Gene

Drugs & Compounds for RPS7 Gene

No Compound Related Data Available

Transcripts for RPS7 Gene

Unigene Clusters for RPS7 Gene

Ribosomal protein S7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPS7 Gene

No ASD Table

Relevant External Links for RPS7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS7 Gene

mRNA expression in normal human tissues for RPS7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS7 Gene

SOURCE GeneReport for Unigene cluster for RPS7 Gene Hs.534346

genes like me logo Genes that share expression patterns with RPS7: view

Protein tissue co-expression partners for RPS7 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS7 Gene

Orthologs for RPS7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPS7 35
  • 88.83 (n)
  • 100 (a)
RPS7 36
  • 100 (a)
(Canis familiaris)
Mammalia RPS7 35
  • 90.38 (n)
  • 100 (a)
RPS7 36
  • 100 (a)
(Mus musculus)
Mammalia Rps7 35
  • 90.38 (n)
  • 100 (a)
Rps7 16
Gm21957 36
  • 77 (a)
Gm6472 36
  • 99 (a)
Gm9493 36
  • 98 (a)
Rps7 36
  • 100 (a)
(Pan troglodytes)
Mammalia RPS7 35
  • 99.83 (n)
  • 100 (a)
RPS7 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rps7 35
  • 89.52 (n)
  • 100 (a)
(Monodelphis domestica)
Mammalia RPS7 36
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia RPS7 36
  • 84 (a)
(Gallus gallus)
Aves RPS7 35
  • 84.71 (n)
  • 99.48 (a)
RPS7 36
  • 98 (a)
(Anolis carolinensis)
Reptilia RPS7 36
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rps7 35
  • 83.16 (n)
  • 98.45 (a)
Str.17080 35
(Danio rerio)
Actinopterygii rps7 35
  • 81.79 (n)
  • 96.39 (a)
zgc73216 35
rps7 36
  • 96 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1883 37
  • 73 (a)
RpS7 35
  • 66.67 (n)
  • 73.02 (a)
RpS7 36
  • 51 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta RS7_ANOGA 35
  • 65.96 (n)
  • 73.02 (a)
(Caenorhabditis elegans)
Secernentea rps-7 37
  • 60 (a)
rps-7 35
  • 61.44 (n)
  • 60.54 (a)
rps-7 36
  • 53 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS7B 35
  • 57.12 (n)
  • 53.51 (a)
RPS7A 36
  • 55 (a)
RPS7B 36
  • 52 (a)
RPS7A 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G48830 35
  • 58.78 (n)
  • 55.38 (a)
(Glycine max)
eudicotyledons Gma.17859 35
(Oryza sativa)
Liliopsida Os03g0297100 35
  • 60.04 (n)
  • 55.38 (a)
(Zea mays)
Liliopsida Zm.16958 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6668 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 79 (a)
Species with no ortholog for RPS7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS7 Gene

Gene Tree for RPS7 (if available)
Gene Tree for RPS7 (if available)

Paralogs for RPS7 Gene

genes like me logo Genes that share paralogs with RPS7: view

No data available for Paralogs for RPS7 Gene

Variants for RPS7 Gene

Sequence variations from dbSNP and Humsavar for RPS7 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs3087873 -- 3,575,950(+) GCCTG(A/G)GAGGG intron-variant
rs2071639 -- 3,580,793(+) TCTTT(A/C)TTTTC intron-variant
rs9808074 -- 3,577,477(+) GATTT(C/T)GTCCA intron-variant
rs9808287 -- 3,577,209(+) TGGGC(A/G)CCTGT intron-variant
rs6759549 -- 3,574,525(+) TGTAA(C/G)TTATT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPS7 Gene

Variant ID Type Subtype PubMed ID
nsv873590 CNV Loss 21882294
nsv873591 CNV Gain 21882294

Variation tolerance for RPS7 Gene

Residual Variation Intolerance Score: 43.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.98; 20.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS7 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS7 Gene

Disorders for RPS7 Gene

MalaCards: The human disease database

(5) MalaCards diseases for RPS7 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
diamond-blackfan anemia 8
  • dba8
diamond-blackfan anemia
  • blackfan - diamond syndrome
rps7-related diamond-blackfan anemia
  • diamond-blackfan anemia 8
pierre robin syndrome
  • pierre robin sequence
macrocytic anemia
  • anemia macrocytic
- elite association - COSMIC cancer census association via MalaCards
Search RPS7 in MalaCards View complete list of genes associated with diseases


  • Diamond-Blackfan anemia 8 (DBA8) [MIM:612563]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. {ECO:0000269 PubMed:19061985}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for RPS7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RPS7: view

No data available for Genatlas for RPS7 Gene

Publications for RPS7 Gene

  1. The human ribosomal protein S7-encoding gene: isolation, structure and localization in 2p25. (PMID: 8522193) Annilo T. … Metspalu A. (Gene 1995) 2 3 4 67
  2. Ribosomal protein S7 is both a regulator and a substrate of MDM2. (PMID: 19683495) Zhu Y. … Prives C. (Mol. Cell 2009) 3 23
  3. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. (PMID: 17310983) Chen D. … Zhang R. (Oncogene 2007) 3 23
  4. Mapping subunit contacts in the regulatory complex of the 26 S proteasome. S2 and S5b form a tetramer with ATPase subunits S4 and S7. (PMID: 10625621) Gorbea C. … Rechsteiner M. (J. Biol. Chem. 2000) 2 3
  5. Luzp4 defines a new mRNA export pathway in cancer cells. (PMID: 25662211) Viphakone N. … Wilson S.A. (Nucleic Acids Res. 2015) 3

Products for RPS7 Gene

Sources for RPS7 Gene