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Aliases for RPS7 Gene

Aliases for RPS7 Gene

  • Ribosomal Protein S7 2 3
  • DBA8 3 6
  • 40S Ribosomal Protein S7 3
  • S7 3

External Ids for RPS7 Gene

Previous GeneCards Identifiers for RPS7 Gene

  • GC02P003100
  • GC02P003265
  • GC02P003187
  • GC02P003116
  • GC02P003600
  • GC02P003622
  • GC02P003564

Summaries for RPS7 Gene

Entrez Gene Summary for RPS7 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS7 Gene

RPS7 (Ribosomal Protein S7) is a Protein Coding gene. Diseases associated with RPS7 include diamond-blackfan anemia 8 and rps7-related diamond-blackfan anemia. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include RNA binding and structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPS7 Gene

  • Required for rRNA maturation.

Gene Wiki entry for RPS7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS7 Gene

Genomics for RPS7 Gene

Regulatory Elements for RPS7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RPS7 Gene

3,575,205 bp from pter
3,580,919 bp from pter
5,715 bases
Plus strand

Genomic View for RPS7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPS7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS7 Gene

Proteins for RPS7 Gene

  • Protein details for RPS7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    40S ribosomal protein S7
    Protein Accession:
    Secondary Accessions:
    • P23821
    • P24818
    • Q57Z92
    • Q6IPH1

    Protein attributes for RPS7 Gene

    194 amino acids
    Molecular mass:
    22127 Da
    Quaternary structure:
    • Binds IPO9 with high affinity. Interacts with NEK6.

    Three dimensional structures from OCA and Proteopedia for RPS7 Gene

neXtProt entry for RPS7 Gene

Proteomics data for RPS7 Gene at MOPED

Post-translational modifications for RPS7 Gene

  • Phosphorylated by NEK6.
  • Ubiquitination at Lys15, Lys49, Lys74, Lys85, Lys90, Lys142, Lys179, and Lys183
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RPS7 Gene

Domains for RPS7 Gene

Gene Families for RPS7 Gene

Protein Domains for RPS7 Gene


Suggested Antigen Peptide Sequences for RPS7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein S7e family.
  • Belongs to the ribosomal protein S7e family.
genes like me logo Genes that share domains with RPS7: view

Function for RPS7 Gene

Molecular function for RPS7 Gene

GENATLAS Biochemistry:
40S ribosomal protein S7,22kDa
UniProtKB/Swiss-Prot Function:
Required for rRNA maturation.

Gene Ontology (GO) - Molecular Function for RPS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding NAS 8522193
GO:0003735 structural constituent of ribosome IEA --
GO:0005515 protein binding IPI 11823430
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPS7: view
genes like me logo Genes that share phenotypes with RPS7: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPS7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS7 Gene

Localization for RPS7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS7 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with NEK6 in the centrosome.

Subcellular locations from

Jensen Localization Image for RPS7 Gene COMPARTMENTS Subcellular localization image for RPS7 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5
chloroplast 2

Gene Ontology (GO) - Cellular Components for RPS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA 11823430
GO:0005737 cytoplasm IDA --
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with RPS7: view

Pathways for RPS7 Gene

SuperPathways for RPS7 Gene

Superpath Contained pathways
1 Influenza Viral RNA Transcription and Replication
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 CFTR translational fidelity (class I mutations)
4 Disease
5 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
genes like me logo Genes that share pathways with RPS7: view

Pathways by source for RPS7 Gene

1 KEGG pathway for RPS7 Gene
1 GeneGo (Thomson Reuters) pathway for RPS7 Gene

Gene Ontology (GO) - Biological Process for RPS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002181 cytoplasmic translation IBA --
GO:0006364 rRNA processing IMP 18697920
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPS7: view

Transcripts for RPS7 Gene

Unigene Clusters for RPS7 Gene

Ribosomal protein S7:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPS7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS7 Gene

No ASD Table

Relevant External Links for RPS7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS7 Gene

mRNA expression in normal human tissues for RPS7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS7 Gene

SOURCE GeneReport for Unigene cluster for RPS7 Gene Hs.534346

genes like me logo Genes that share expressions with RPS7: view

Expression partners for RPS7 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS7 Gene

Orthologs for RPS7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPS7 35
  • 88.83 (n)
  • 100 (a)
RPS7 36
  • 100 (a)
(Canis familiaris)
Mammalia RPS7 35
  • 90.38 (n)
  • 100 (a)
RPS7 36
  • 100 (a)
(Mus musculus)
Mammalia Rps7 35
  • 90.38 (n)
  • 100 (a)
Rps7 16
Gm21957 36
  • 77 (a)
Gm6472 36
  • 99 (a)
Gm9493 36
  • 98 (a)
Rps7 36
  • 100 (a)
(Pan troglodytes)
Mammalia RPS7 35
  • 99.83 (n)
  • 100 (a)
RPS7 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rps7 35
  • 89.52 (n)
  • 100 (a)
(Monodelphis domestica)
Mammalia RPS7 36
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia RPS7 36
  • 84 (a)
(Gallus gallus)
Aves RPS7 35
  • 84.71 (n)
  • 99.48 (a)
RPS7 36
  • 98 (a)
(Anolis carolinensis)
Reptilia RPS7 36
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rps7 35
  • 83.16 (n)
  • 98.45 (a)
Str.17080 35
(Danio rerio)
Actinopterygii rps7 35
  • 81.79 (n)
  • 96.39 (a)
zgc73216 35
rps7 36
  • 96 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1883 37
  • 73 (a)
RpS7 35
  • 66.67 (n)
  • 73.02 (a)
RpS7 36
  • 51 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta RS7_ANOGA 35
  • 65.96 (n)
  • 73.02 (a)
(Caenorhabditis elegans)
Secernentea rps-7 37
  • 60 (a)
rps-7 35
  • 61.44 (n)
  • 60.54 (a)
rps-7 36
  • 53 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS7B 35
  • 57.12 (n)
  • 53.51 (a)
RPS7A 36
  • 55 (a)
RPS7B 36
  • 52 (a)
RPS7A 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G48830 35
  • 58.78 (n)
  • 55.38 (a)
(Glycine max)
eudicotyledons Gma.17859 35
(Oryza sativa)
Liliopsida Os03g0297100 35
  • 60.04 (n)
  • 55.38 (a)
(Zea mays)
Liliopsida Zm.16958 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6668 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 79 (a)
Species with no ortholog for RPS7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS7 Gene

Gene Tree for RPS7 (if available)
Gene Tree for RPS7 (if available)

Paralogs for RPS7 Gene

genes like me logo Genes that share paralogs with RPS7: view

No data available for Paralogs for RPS7 Gene

Variants for RPS7 Gene

Sequence variations from dbSNP and Humsavar for RPS7 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs573443780 -- 3,575,342(+) CGGCG(C/T)TCGGC utr-variant-5-prime
rs573727534 -- 3,576,245(+) TGGGG(G/T)TGCAG intron-variant
rs573319121 -- 3,577,268(+) GAGGT(A/G)GAGCT intron-variant
rs572831490 -- 3,576,175(+) AGATA(C/G)GGCAA intron-variant
rs572802131 -- 3,580,957(+) ATTCA(C/T)GGATG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RPS7 Gene

Variant ID Type Subtype PubMed ID
nsv873590 CNV Loss 21882294
nsv873591 CNV Gain 21882294

Relevant External Links for RPS7 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS7 Gene

Disorders for RPS7 Gene

(1) OMIM Diseases for RPS7 Gene (603658)


  • Diamond-Blackfan anemia 8 (DBA8) [MIM:612563]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. {ECO:0000269 PubMed:19061985}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for RPS7 Gene

Relevant External Links for RPS7

genes like me logo Genes that share disorders with RPS7: view

No data available for Novoseek inferred disease relationships and Genatlas for RPS7 Gene

Publications for RPS7 Gene

  1. The human ribosomal protein S7-encoding gene: isolation, structure and localization in 2p25. (PMID: 8522193) Annilo T. … Metspalu A. (Gene 1995) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Ribosomal protein L5 and L11 mutations are associated with cleft palate and abnormal thumbs in Diamond-Blackfan anemia patients. (PMID: 19061985) Gazda H.T. … Beggs A.H. (Am. J. Hum. Genet. 2008) 3 4
  5. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. (PMID: 17310983) Chen D. … Zhang R. (Oncogene 2007) 3 23

Products for RPS7 Gene

Sources for RPS7 Gene

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