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Aliases for RPS7 Gene

Aliases for RPS7 Gene

  • Ribosomal Protein S7 2 3
  • DBA8 3 6
  • 40S Ribosomal Protein S7 3
  • S7 3

External Ids for RPS7 Gene

Summaries for RPS7 Gene

Entrez Gene Summary for RPS7 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS7 Gene

RPS7 (Ribosomal Protein S7) is a Protein Coding gene. Diseases associated with RPS7 include diamond-blackfan anemia 8 and rps7-related diamond-blackfan anemia. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include RNA binding and structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPS7 Gene

  • Required for rRNA maturation.

Gene Wiki entry for RPS7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS7 Gene

Genomics for RPS7 Gene

Genomic Location for RPS7 Gene

Start:
3,575,205 bp from pter
End:
3,580,919 bp from pter
Size:
5,715 bases
Orientation:
Plus strand

Genomic View for RPS7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPS7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS7 Gene

Regulatory Elements for RPS7 Gene

Proteins for RPS7 Gene

  • Protein details for RPS7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62081-RS7_HUMAN
    Recommended name:
    40S ribosomal protein S7
    Protein Accession:
    P62081
    Secondary Accessions:
    • P23821
    • P24818
    • Q57Z92
    • Q6IPH1

    Protein attributes for RPS7 Gene

    Size:
    194 amino acids
    Molecular mass:
    22127 Da
    Quaternary structure:
    • Binds IPO9 with high affinity. Interacts with NEK6.

    Three dimensional structures from OCA and Proteopedia for RPS7 Gene

neXtProt entry for RPS7 Gene

Proteomics data for RPS7 Gene at MOPED

Post-translational modifications for RPS7 Gene

  • Phosphorylated by NEK6.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys15, Lys49, Lys74, Lys85, Lys90, Lys142, Lys179, and Lys183

Other Protein References for RPS7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RPS7 Gene

Domains for RPS7 Gene

Gene Families for RPS7 Gene

HGNC:
  • RPS :S ribosomal proteins

Protein Domains for RPS7 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

RS7_HUMAN
Family:
  • Belongs to the ribosomal protein S7e family.:
    • P62081
genes like me logo Genes that share domains with RPS7: view

Function for RPS7 Gene

Molecular function for RPS7 Gene

GENATLAS Biochemistry: 40S ribosomal protein S7,22kDa
UniProtKB/Swiss-Prot Function: Required for rRNA maturation.

Gene Ontology (GO) - Molecular Function for RPS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding NAS 8522193
GO:0003735 structural constituent of ribosome IEA --
GO:0005515 protein binding IPI 11823430
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPS7: view
genes like me logo Genes that share phenotypes with RPS7: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPS7 Gene

Localization for RPS7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS7 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with NEK6 in the centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS7 Gene COMPARTMENTS Subcellular localization image for RPS7 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5
chloroplast 2

Gene Ontology (GO) - Cellular Components for RPS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA 11823430
GO:0005737 cytoplasm IDA --
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with RPS7: view

Pathways for RPS7 Gene

SuperPathways for RPS7 Gene

Superpath Contained pathways
1 Influenza Viral RNA Transcription and Replication
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 CFTR translational fidelity (class I mutations)
.54
4 Disease
5 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
genes like me logo Genes that share pathways with RPS7: view

Pathways by source for RPS7 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for RPS7 Gene
1 BioSystems pathway for RPS7 Gene

Gene Ontology (GO) - Biological Process for RPS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002181 cytoplasmic translation IBA --
GO:0006364 rRNA processing IMP 18697920
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPS7: view

Transcripts for RPS7 Gene

Unigene Clusters for RPS7 Gene

Ribosomal protein S7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPS7 Gene

No ASD Table

Relevant External Links for RPS7 Gene

GeneLoc Exon Structure for
RPS7
ECgene alternative splicing isoforms for
RPS7

Expression for RPS7 Gene

mRNA expression in normal human tissues for RPS7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS7 Gene

SOURCE GeneReport for Unigene cluster for RPS7 Gene Hs.534346

genes like me logo Genes that share expressions with RPS7: view

Orthologs for RPS7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPS7 36
  • 99.83 (n)
  • 100 (a)
RPS7 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RPS7 36
  • 88.83 (n)
  • 100 (a)
RPS7 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPS7 36
  • 90.38 (n)
  • 100 (a)
RPS7 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm21957 37
  • 77 (a)
OneToMany
Gm6472 37
  • 99 (a)
OneToMany
Gm9493 37
  • 98 (a)
OneToMany
Rps7 36
  • 90.38 (n)
  • 100 (a)
Rps7 16
Rps7 37
  • 100 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia RPS7 37
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPS7 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rps7 36
  • 89.52 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves RPS7 36
  • 84.71 (n)
  • 99.48 (a)
RPS7 37
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPS7 37
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rps7 36
  • 83.16 (n)
  • 98.45 (a)
Str.17080 36
zebrafish
(Danio rerio)
Actinopterygii rps7 36
  • 81.79 (n)
  • 96.39 (a)
rps7 37
  • 96 (a)
OneToOne
zgc73216 36
African malaria mosquito
(Anopheles gambiae)
Insecta RS7_ANOGA 36
  • 65.96 (n)
  • 73.02 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpS7 36
  • 66.67 (n)
  • 73.02 (a)
RpS7 37
  • 51 (a)
OneToOne
CG1883 38
  • 73 (a)
worm
(Caenorhabditis elegans)
Secernentea rps-7 36
  • 61.44 (n)
  • 60.54 (a)
rps-7 37
  • 53 (a)
OneToOne
rps-7 38
  • 60 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS7A 37
  • 55 (a)
OneToMany
RPS7A 39
RPS7B 36
  • 57.12 (n)
  • 53.51 (a)
RPS7B 37
  • 52 (a)
OneToMany
soybean
(Glycine max)
eudicotyledons Gma.17859 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G48830 36
  • 58.78 (n)
  • 55.38 (a)
corn
(Zea mays)
Liliopsida Zm.16958 36
rice
(Oryza sativa)
Liliopsida Os03g0297100 36
  • 60.04 (n)
  • 55.38 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6668 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 79 (a)
OneToOne
Species with no ortholog for RPS7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS7 Gene

ENSEMBL:
Gene Tree for RPS7 (if available)
TreeFam:
Gene Tree for RPS7 (if available)

Paralogs for RPS7 Gene

genes like me logo Genes that share paralogs with RPS7: view

No data available for Paralogs for RPS7 Gene

Variants for RPS7 Gene

Sequence variations from dbSNP and Humsavar for RPS7 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs2071639 -- 3,580,793(+) TCTTT(A/C)TTTTC intron-variant
rs3087873 -- 3,575,950(+) GCCTG(A/G)GAGGG intron-variant
rs6759549 -- 3,574,525(+) TGTAA(C/G)TTATT upstream-variant-2KB
rs7576238 -- 3,580,058(+) GAGTT(C/G)CCCAG intron-variant
rs9808074 -- 3,577,477(+) GATTT(C/T)GTCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPS7 Gene

Variant ID Type Subtype PubMed ID
nsv873590 CNV Loss 21882294
nsv873591 CNV Gain 21882294

Relevant External Links for RPS7 Gene

HapMap Linkage Disequilibrium report
RPS7
Human Gene Mutation Database (HGMD)
RPS7
Locus Specific Mutation Databases (LSDB)
RPS7

Disorders for RPS7 Gene

(1) OMIM Diseases for RPS7 Gene (603658)

UniProtKB/Swiss-Prot

RS7_HUMAN
  • Diamond-Blackfan anemia 8 (DBA8) [MIM:612563]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. {ECO:0000269 PubMed:19061985}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for RPS7 Gene

Relevant External Links for RPS7

GeneTests
RPS7
GeneReviews
RPS7
genes like me logo Genes that share disorders with RPS7: view

Publications for RPS7 Gene

  1. The human ribosomal protein S7-encoding gene: isolation, structure and localization in 2p25. (PMID: 8522193) Annilo T. … Metspalu A. (Gene 1995) 2 3 4
  2. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PMID: 8706699) Vladimirov S.N. … Otto A. (Eur. J. Biochem. 1996) 3 4
  3. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. (PMID: 17310983) Chen D. … Zhang R. (Oncogene 2007) 3 23
  4. Mapping subunit contacts in the regulatory complex of the 26 S proteasome. S2 and S5b form a tetramer with ATPase subunits S4 and S7. (PMID: 10625621) Gorbea C. … Rechsteiner M. (J. Biol. Chem. 2000) 2 3
  5. Importins fulfill a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains. (PMID: 11823430) Jaekel S. … Goerlich D. (EMBO J. 2002) 3 4

Products for RPS7 Gene

Sources for RPS7 Gene

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