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Aliases for RPS6KL1 Gene

Aliases for RPS6KL1 Gene

  • Ribosomal Protein S6 Kinase-Like 1 2 3
  • EC 2.7.11.1 4
  • RSKL2 3

External Ids for RPS6KL1 Gene

Previous GeneCards Identifiers for RPS6KL1 Gene

  • GC14M069189
  • GC14M073362
  • GC14M074442
  • GC14M075372
  • GC14M055540

Summaries for RPS6KL1 Gene

GeneCards Summary for RPS6KL1 Gene

RPS6KL1 (Ribosomal Protein S6 Kinase-Like 1) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is SNX15.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS6KL1 Gene

Genomics for RPS6KL1 Gene

Regulatory Elements for RPS6KL1 Gene

Genomic Location for RPS6KL1 Gene

Start:
74,903,812 bp from pter
End:
74,923,396 bp from pter
Size:
19,585 bases
Orientation:
Minus strand

Genomic View for RPS6KL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPS6KL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS6KL1 Gene

Proteins for RPS6KL1 Gene

  • Protein details for RPS6KL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6S9-RPKL1_HUMAN
    Recommended name:
    Ribosomal protein S6 kinase-like 1
    Protein Accession:
    Q9Y6S9
    Secondary Accessions:
    • A6NGM9
    • Q69YT9
    • Q6ZMQ6
    • Q96NR9
    • Q9BSU9

    Protein attributes for RPS6KL1 Gene

    Size:
    549 amino acids
    Molecular mass:
    60036 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RPS6KL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPS6KL1 Gene

Proteomics data for RPS6KL1 Gene at MOPED

Post-translational modifications for RPS6KL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RPS6KL1 Gene

Domains for RPS6KL1 Gene

Protein Domains for RPS6KL1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RPS6KL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6S9

UniProtKB/Swiss-Prot:

RPKL1_HUMAN :
  • Q9Y6S9
Domain:
  • Contains 1 MIT domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. S6 kinase subfamily.
genes like me logo Genes that share domains with RPS6KL1: view

Function for RPS6KL1 Gene

Molecular function for RPS6KL1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein

Enzyme Numbers (IUBMB) for RPS6KL1 Gene

Gene Ontology (GO) - Molecular Function for RPS6KL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0004713 protein tyrosine kinase activity --
GO:0005524 ATP binding IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups --
genes like me logo Genes that share ontologies with RPS6KL1: view

Phenotypes for RPS6KL1 Gene

GenomeRNAi human phenotypes for RPS6KL1:
genes like me logo Genes that share phenotypes with RPS6KL1: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RPS6KL1 Gene

Localization for RPS6KL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS6KL1 Gene COMPARTMENTS Subcellular localization image for RPS6KL1 gene
Compartment Confidence
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for RPS6KL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005840 ribosome IEA --
GO:0043231 intracellular membrane-bounded organelle IBA --
genes like me logo Genes that share ontologies with RPS6KL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS6KL1 Gene

Pathways for RPS6KL1 Gene

SuperPathways for RPS6KL1 Gene

No Data Available

Interacting Proteins for RPS6KL1 Gene

Selected Interacting proteins: Q9Y6S9-RPKL1_HUMAN for RPS6KL1 Gene via I2D

Symbol External ID(s) Details
SEPT2

Gene Ontology (GO) - Biological Process for RPS6KL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction IBA --
genes like me logo Genes that share ontologies with RPS6KL1: view

No data available for Pathways by source for RPS6KL1 Gene

Transcripts for RPS6KL1 Gene

Unigene Clusters for RPS6KL1 Gene

Ribosomal protein S6 kinase-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPS6KL1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d ^ 11 ^ 12a ·
SP1: - - - - -
SP2: - -
SP3: -
SP4: - - - - -
SP5: - - -
SP6: -
SP7: - - - - -
SP8:
SP9:
SP10: -
SP11: -
SP12:
SP13: -
SP14:

ExUns: 12b ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c · 15d
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: - -
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for RPS6KL1 Gene

GeneLoc Exon Structure for
RPS6KL1
ECgene alternative splicing isoforms for
RPS6KL1

Expression for RPS6KL1 Gene

mRNA expression in normal human tissues for RPS6KL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for RPS6KL1 Gene

SOURCE GeneReport for Unigene cluster for RPS6KL1 Gene Hs.414481

genes like me logo Genes that share expressions with RPS6KL1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS6KL1 Gene

Orthologs for RPS6KL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RPS6KL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPS6KL1 35
  • 99.51 (n)
  • 99.09 (a)
RPS6KL1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RPS6KL1 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPS6KL1 35
  • 85.11 (n)
  • 81.8 (a)
RPS6KL1 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rps6kl1 35
  • 80.82 (n)
  • 79.41 (a)
Rps6kl1 16
Rps6kl1 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RPS6KL1 36
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rps6kl1 35
  • 81.19 (n)
  • 79.96 (a)
chicken
(Gallus gallus)
Aves RPS6KL1 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPS6KL1 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rps6kl1 35
  • 59.12 (n)
  • 55.52 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101886230 35
  • 64.61 (n)
  • 60.96 (a)
rps6kl1 36
  • 33 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7156 36
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rskd-1 36
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 17 (a)
OneToMany
Species with no ortholog for RPS6KL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS6KL1 Gene

ENSEMBL:
Gene Tree for RPS6KL1 (if available)
TreeFam:
Gene Tree for RPS6KL1 (if available)

Paralogs for RPS6KL1 Gene

Paralogs for RPS6KL1 Gene

Selected SIMAP similar genes for RPS6KL1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RPS6KL1: view

Variants for RPS6KL1 Gene

Sequence variations from dbSNP and Humsavar for RPS6KL1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs722685 -- 74,915,979(+) GCCCT(C/T)GGGTA intron-variant
rs722686 -- 74,916,007(+) GTCCC(A/G)ACCCA intron-variant
rs722687 -- 74,916,063(+) CCTAA(C/T)AGCCG intron-variant
rs759057 -- 74,911,628(+) GTGTG(C/T)GCATG intron-variant
rs759058 -- 74,916,268(+) ATTTG(A/G)GGAAA intron-variant

Relevant External Links for RPS6KL1 Gene

HapMap Linkage Disequilibrium report
RPS6KL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RPS6KL1 Gene

Disorders for RPS6KL1 Gene

No disorders were found for RPS6KL1 Gene.

No data available for UniProtKB/Swiss-Prot for RPS6KL1 Gene

Publications for RPS6KL1 Gene

  1. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PMID: 16751776) Girard A. … Carmell M.A. (Nature 2006) 3
  5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3

Products for RPS6KL1 Gene

Sources for RPS6KL1 Gene

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