RPS6KL1 Gene
protein-coding GIFtS : 45
GCID: GC14 M075372
ribosomal protein S6 kinase-like 1
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Aliasesfor RPS6KL1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Ribosomal Protein S6 Kinase-Like 1 1 2 MGC112871 EC 2.7.11.13
Export aliases for RPS6KL1 gene to outside databases Previous GC identifers: GC14M069189 GC14M073362 GC14M074442 GC14M055540
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Summariesfor RPS6KL1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor RPS6KL1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000014.8 NC_018925.1 NT_026437.12 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the RPS6KL1 gene promoter: Pax-5 MyoD RelA NF-kappaB C/EBPalpha YY1 AREB6 c-Myb ZIC2/Zic2 NF-kappaB1 Other transcription factors Search SABiosciences Chromatin IP Primers for RPS6KL1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat RPS6KL1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 14q24.3 Ensembl cytogenetic band: 14q24.3 HGNC cytogenetic band: 14q24.2 RPS6KL1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 14 GeneLoc Exon Structure
GeneLoc location for GC14M075372: view genomic region
(about GC identifiers )
Start:
75,370,657 bp from pter
End:
75,390,099 bp from pter
Size:
19,443 bases
Orientation:
minus strand
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Proteinsfor RPS6KL1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: RPKL1_HUMAN, Q9Y6S9 (See
protein sequence )Recommended Name: Ribosomal protein S6 kinase-like 1 Size : 549 amino acids; 60036 Da
Secondary accessions : A6NGM9 Q69YT9 Q6ZMQ6 Q96NR9 Q9BSU9Alternative splicing : 3 isoforms : Q9Y6S9-1 Q9Y6S9-2 Q9Y6S9-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for RPS6KL1: NX_Q9Y6S9 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9Y6S9 RPS6KL1 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_113652.2 ENSEMBL proteins: ENSP00000451986 ENSP00000450660 ENSP00000452027 ENSP00000451795 ENSP00000450968 ENSP00000451152 ENSP00000450846 ENSP00000450567 ENSP00000451338 ENSP00000346644 ENSP00000351086 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005840 ribosome
IEA --
RPS6KL1 for ontologies About GeneDecksing RPS6KL1 Antibody Products: Assay Products for RPS6KL1:
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Protein
Domains / Familiesfor RPS6KL1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
RPS6KL1 for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9Y6S9 ProtoNet protein and cluster: Q9Y6S9
1 Blocks protein family : IPB007330 MIT UniProtKB/Swiss-Prot: RPKL1_HUMAN, Q9Y6S9 Similarity : Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. S6 kinase subfamilySimilarity : Contains 1 MIT domainSimilarity : Contains 1 protein kinase domain
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Functionfor RPS6KL1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: RPKL1_HUMAN, Q9Y6S9 Catalytic activity : ATP + a protein = ADP + a phosphoproteinEnzyme Number (IUBMB): EC 2.7.11.1 1
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RPS6KL1 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RPS6KL1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: RPS6KL1 (NM_031464 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPS6KL1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RPS6KL1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS6KL1
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0004672 protein kinase activity
-- -- GO:0004674 protein serine/threonine kinase activity
IEA -- GO:0005524 ATP binding
IEA --
RPS6KL1 for ontologies About GeneDecksing 2 GenomeRNAi human phenotypes for RPS6KL1 :Animal Models: Mouse knock-out Rps6kl1 tm1Lex for RPS6KL1 1 MGI phenotypic allele for Rps6kl1 (no phenotypes)
RPS6KL1 for phenotypes About GeneDecksing
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Pathways & Interactionsfor RPS6KL1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPS6KL1 1 Interacting protein for RPS6KL1 (Q9Y6S9 3 ) via UniProtKB, MINT, STRING, and/or I2D About this table
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Drugs & Compoundsfor RPS6KL1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for RPS6KL1 Search CenterWatch for drugs/clinical trials and news about RPS6KL1 / RPKL1
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Transcriptsfor RPS6KL1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for RPS6KL1 gene: NM_031464.4 Unigene Cluster for RPS6KL1:
Ribosomal protein S6 kinase-like 1 Hs.414481 [show with all ESTs ] Unigene Representative Sequence: AK226137 17 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000555834 (uc010tux.2 ) ENST00000555910 ENST00000555009 (uc021rwp.1 )ENST00000555647 ENST00000556848 ENST00000553646 (uc001xqx.1 ) ENST00000553315 ENST00000553971 ENST00000553789 ENST00000557413 ENST00000554834 ENST00000553894 (uc001xqy.1 )ENST00000554900 ENST00000557383 ENST00000556776 ENST00000354625 (uc010asd.2 )ENST00000358328 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RPS6KL1 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RPS6KL1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: RPS6KL1 (NM_031464 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPS6KL1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RPS6KL1
Additional cDNA sequence: AK054800.1 AK093053.1 AK131532.1 AK226137.1 AK299846.1 AL390152.1 BC004540.2 BC036574.2
11 DOTS entries : DT.92420669 DT.70100085
DT.443812 DT.100752035 DT.92420670 DT.97829585 DT.91963841 DT.40189703 DT.70102103 DT.99946380 DT.100752036 24/68 AceView cDNA sequences (see all 68 ):
BE348501 BC004540 AW204981 CA843509 AW450734 NM_031464 Z40976 BX645396 CA946840 AI341390 AI867930 BU500608 AK054800 AI355549 AL042499 AW452596 AW873355 AI419172 AI911176 BC036574 AX747888 AK131532 F07900 BE219345 GeneLoc Exon Structure 5/14 Alternative Splicing Database (ASD) splice patterns (SP) for RPS6KL1 (see all 14 ) About this scheme ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d ^ 11 ^ 12a · SP1 :                                         -   -   -   -   -     SP2 :                                   -       -             SP3 :                                                   -   SP4 :         -   -   -   -   -                                     SP5 :             -   -   -                                    
ExUns: 12b ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c · 15d SP1 :       -           SP2 :                 SP3 :                 SP4 :                 SP5 :                
ECgene alternative splicing isoforms for RPS6KL1
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Expression for RPS6KL1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section RPS6KL1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: ACTCTCTGTG
About this image RPS6KL1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 2 LifeMap In Vivo Development Anatomical Compartments/Cells Tissue Anatomical Compartment
Cell Category (developmental path) Gut Tube Midgut Midgut Endoderm Cells Endoderm Gut Tube Midgut Gut Tube Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See RPS6KL1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for RPS6KL1 SOURCE GeneReport for Unigene cluster: Hs.414481 SABiosciences Custom PCR Arrays for RPS6KL1 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for RPS6KL1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat RPS6KL1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat RPS6KL1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat RPS6KL1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS6KL1
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Orthologsfor RPS6KL1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for RPS6KL1 gene from 6/14 species (see all 14 ) About this table
ENSEMBL Gene Tree for RPS6KL1 (if available)TreeFam Gene Tree for RPS6KL1 (if available)
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Paralogsfor RPS6KL1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for RPS6KL1 gene SNX15 2 RPS6KC1 2 5 SIMAP similar genes for RPS6KL1 using alignment to 6 protein entries: RPKL1_HUMAN (see all proteins ):RPS6KC1 RPS6KA1 AKT2 PRKACB RPS6KA4
RPS6KL1 for paralogs About GeneDecksing
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Genomic Variantsfor RPS6KL1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 14 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for RPS6KL1 (75370657 - 75390099 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for RPS6KL1: -- Human Gene Mutation Database (HGMD) : RPS6KL1 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing RPS6KL1
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Disorders
/ Diseasesfor RPS6KL1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section RPS6KL1 for disorders About MalaCards
RPS6KL1 for disorders About GeneDecksing Export disorders for RPS6KL1 gene to outside databases
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Publicationsfor RPS6KL1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for RPS6KL1 gene integrated from 9 sources : (articles sorted by number of sources associating them with RPS6KL1) Utopia : connect your pdf to the dynamic world of online information
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121) 1 , 2 Heilig R.... Weissenbach J. (2003) Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846) 2 Greenman C.... Stratton M.R. (2007) The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005) 2 Bechtel S.... Schupp I. (2007) A germline-specific class of small RNAs binds mammali an Piwi proteins. (PubMed id 16751776) 1 Girard A....Carmell M.A. (2006) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for RPS6KL1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing RPS6KL1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing RPS6KL1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing RPS6KL1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for RPS6KL1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for RPS6KL1 gene: Search GeneIP for patents involving RPS6KL1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor RPS6KL1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for RPS6KL1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for RPS6KL1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for RPS6KL1 OriGene Protein Over-expression Lysate for RPS6KL1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for RPS6KL1 OriGene 3'-UTR Clone for RPS6KL1 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RPS6KL1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RPS6KL1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for RPS6KL1 OriGene Custom Protein Services for RPS6KL1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RPS6KL1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing RPS6KL1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat RPS6KL1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat RPS6KL1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat RPS6KL1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat RPS6KL1
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RPS6KL1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS6KL1
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RPS6KL1
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