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Aliases for RPS6KL1 Gene

Aliases for RPS6KL1 Gene

  • Ribosomal Protein S6 Kinase Like 1 2 3 5
  • Ribosomal Protein S6 Kinase-Like 1 2
  • EC 4
  • RSKL2 3

External Ids for RPS6KL1 Gene

Previous GeneCards Identifiers for RPS6KL1 Gene

  • GC14M069189
  • GC14M073362
  • GC14M074442
  • GC14M075372
  • GC14M055540

Summaries for RPS6KL1 Gene

GeneCards Summary for RPS6KL1 Gene

RPS6KL1 (Ribosomal Protein S6 Kinase Like 1) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is SNX15.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS6KL1 Gene

Genomics for RPS6KL1 Gene

Regulatory Elements for RPS6KL1 Gene

Enhancers for RPS6KL1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPS6KL1 on UCSC Golden Path with GeneCards custom track

Promoters for RPS6KL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPS6KL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPS6KL1 Gene

74,902,849 bp from pter
74,923,396 bp from pter
20,548 bases
Minus strand

Genomic View for RPS6KL1 Gene

Genes around RPS6KL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS6KL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS6KL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS6KL1 Gene

Proteins for RPS6KL1 Gene

  • Protein details for RPS6KL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribosomal protein S6 kinase-like 1
    Protein Accession:
    Secondary Accessions:
    • A6NGM9
    • Q69YT9
    • Q6ZMQ6
    • Q96NR9
    • Q9BSU9

    Protein attributes for RPS6KL1 Gene

    549 amino acids
    Molecular mass:
    60036 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RPS6KL1 Gene


neXtProt entry for RPS6KL1 Gene

Proteomics data for RPS6KL1 Gene at MOPED

Post-translational modifications for RPS6KL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RPS6KL1 Gene

Domains & Families for RPS6KL1 Gene

Protein Domains for RPS6KL1 Gene


Suggested Antigen Peptide Sequences for RPS6KL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 MIT domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. S6 kinase subfamily.
  • Contains 1 MIT domain.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. S6 kinase subfamily.
genes like me logo Genes that share domains with RPS6KL1: view

Function for RPS6KL1 Gene

Molecular function for RPS6KL1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for RPS6KL1 Gene

genes like me logo Genes that share phenotypes with RPS6KL1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RPS6KL1

CRISPR Products

miRNA for RPS6KL1 Gene

miRTarBase miRNAs that target RPS6KL1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS6KL1 Gene

Localization for RPS6KL1 Gene

Subcellular locations from

Jensen Localization Image for RPS6KL1 Gene COMPARTMENTS Subcellular localization image for RPS6KL1 gene
Compartment Confidence
nucleus 4
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RPS6KL1 Gene

Pathways & Interactions for RPS6KL1 Gene

SuperPathways for RPS6KL1 Gene

No Data Available

Interacting Proteins for RPS6KL1 Gene

Selected Interacting proteins: Q9Y6S9-RPKL1_HUMAN for RPS6KL1 Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for RPS6KL1 Gene


No data available for Pathways by source and SIGNOR curated interactions for RPS6KL1 Gene

Drugs & Compounds for RPS6KL1 Gene

No Compound Related Data Available

Transcripts for RPS6KL1 Gene

Unigene Clusters for RPS6KL1 Gene

Ribosomal protein S6 kinase-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPS6KL1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d ^ 11 ^ 12a ·
SP1: - - - - -
SP2: - -
SP3: -
SP4: - - - - -
SP5: - - -
SP6: -
SP7: - - - - -
SP10: -
SP11: -
SP13: -

ExUns: 12b ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c · 15d
SP1: -
SP9: - -

Relevant External Links for RPS6KL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS6KL1 Gene

mRNA expression in normal human tissues for RPS6KL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPS6KL1 Gene

This gene is overexpressed in Heart (45.5) and Peripheral blood mononuclear cells (23.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RPS6KL1 Gene

SOURCE GeneReport for Unigene cluster for RPS6KL1 Gene Hs.414481

genes like me logo Genes that share expression patterns with RPS6KL1: view

Protein tissue co-expression partners for RPS6KL1 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS6KL1 Gene

Orthologs for RPS6KL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RPS6KL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia RPS6KL1 35
  • 85.11 (n)
  • 81.8 (a)
RPS6KL1 36
  • 81 (a)
(Mus musculus)
Mammalia Rps6kl1 35
  • 80.82 (n)
  • 79.41 (a)
Rps6kl1 16
Rps6kl1 36
  • 79 (a)
(Pan troglodytes)
Mammalia RPS6KL1 35
  • 99.51 (n)
  • 99.09 (a)
RPS6KL1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Rps6kl1 35
  • 81.19 (n)
  • 79.96 (a)
(Bos Taurus)
Mammalia RPS6KL1 36
  • 78 (a)
(Monodelphis domestica)
Mammalia RPS6KL1 36
  • 60 (a)
(Gallus gallus)
Aves RPS6KL1 36
  • 51 (a)
(Anolis carolinensis)
Reptilia RPS6KL1 36
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rps6kl1 35
  • 59.12 (n)
  • 55.52 (a)
(Danio rerio)
Actinopterygii LOC101886230 35
  • 64.61 (n)
  • 60.96 (a)
rps6kl1 36
  • 33 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7156 36
  • 19 (a)
(Caenorhabditis elegans)
Secernentea rskd-1 36
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 17 (a)
Species with no ortholog for RPS6KL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS6KL1 Gene

Gene Tree for RPS6KL1 (if available)
Gene Tree for RPS6KL1 (if available)

Paralogs for RPS6KL1 Gene

Paralogs for RPS6KL1 Gene

(4) SIMAP similar genes for RPS6KL1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RPS6KL1: view

Variants for RPS6KL1 Gene

Sequence variations from dbSNP and Humsavar for RPS6KL1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs7156590 - 74,921,480(+) GTGCT(C/T)GTGAG nc-transcript-variant, reference, missense
rs2286913 - 74,919,873(+) TCAGC(A/G)GCCGC nc-transcript-variant, reference, missense
VAR_041067 -
rs722685 -- 74,915,979(+) GCCCT(C/T)GGGTA intron-variant
rs722686 -- 74,916,007(+) GTCCC(A/G)ACCCA intron-variant

Variation tolerance for RPS6KL1 Gene

Residual Variation Intolerance Score: 95.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.23; 96.22% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for RPS6KL1 Gene

Disorders for RPS6KL1 Gene

Relevant External Links for RPS6KL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RPS6KL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPS6KL1 Gene

Publications for RPS6KL1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3
  3. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PMID: 16751776) Girard A. … Carmell M.A. (Nature 2006) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3

Products for RPS6KL1 Gene

Sources for RPS6KL1 Gene