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Aliases for RPS6KC1 Gene

Aliases for RPS6KC1 Gene

  • Ribosomal Protein S6 Kinase, 52kDa, Polypeptide 1 2 3
  • Ribosomal S6 Kinase-Like Protein With Two PSK Domains 118 KDa Protein 3 4
  • 52 KDa Ribosomal Protein S6 Kinase 3 4
  • SPHK1-Binding Protein 3 4
  • S6K-Delta-1 3 4
  • RPK118 3 4
  • Ribosomal Protein S6 Kinase, 52kD, Polypeptide 1 2
  • Ribosomal Protein S6 Kinase Delta-1 3
  • EC 4
  • HumS6PKh1 3
  • S6PKh1 3
  • RSKL1 3

External Ids for RPS6KC1 Gene

Previous GeneCards Identifiers for RPS6KC1 Gene

  • GC01P212070
  • GC01P209067
  • GC01P209840
  • GC01P210281
  • GC01P209612
  • GC01P211291
  • GC01P213224
  • GC01P183899

Summaries for RPS6KC1 Gene

GeneCards Summary for RPS6KC1 Gene

RPS6KC1 (Ribosomal Protein S6 Kinase, 52kDa, Polypeptide 1) is a Protein Coding gene. Among its related pathways are Nanog in Mammalian ESC Pluripotency and CNTF Signaling. GO annotations related to this gene include protein serine/threonine kinase activity and phosphatidylinositol binding. An important paralog of this gene is RPS6KL1.

UniProtKB/Swiss-Prot for RPS6KC1 Gene

  • May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell

Gene Wiki entry for RPS6KC1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS6KC1 Gene

Genomics for RPS6KC1 Gene

Regulatory Elements for RPS6KC1 Gene

Genomic Location for RPS6KC1 Gene

213,051,233 bp from pter
213,274,773 bp from pter
223,541 bases
Plus strand

Genomic View for RPS6KC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPS6KC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS6KC1 Gene

Proteins for RPS6KC1 Gene

  • Protein details for RPS6KC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribosomal protein S6 kinase delta-1
    Protein Accession:
    Secondary Accessions:
    • B1APS8
    • B3KVM4
    • D3DTA4
    • Q8TDD3
    • Q9NSF4
    • Q9UL66

    Protein attributes for RPS6KC1 Gene

    1066 amino acids
    Molecular mass:
    118682 Da
    Quaternary structure:
    • Interacts with SPHK1 and phosphatidylinositol 3-phosphate.
    • Sequence=CAB92850.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RPS6KC1 Gene


neXtProt entry for RPS6KC1 Gene

Proteomics data for RPS6KC1 Gene at MOPED

Post-translational modifications for RPS6KC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for RPS6KC1 Gene

Domains for RPS6KC1 Gene

Protein Domains for RPS6KC1 Gene


Suggested Antigen Peptide Sequences for RPS6KC1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q96S38
  • The first protein kinase domain appears to be a pseudokinase domain as it does not contain the classical characteristics, such as the ATP-binding motif, ATP-binding site and active site
  • Contains 1 MIT domain.
  • Contains 2 protein kinase domains.
  • Contains 1 PX (phox homology) domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. S6 kinase subfamily.
genes like me logo Genes that share domains with RPS6KC1: view

Function for RPS6KC1 Gene

Molecular function for RPS6KC1 Gene

GENATLAS Biochemistry:
ribosomal protein S6 kinase,polypeptide 1,expressed highly in testis,skeletal muscle,brain and pancreas,not involved in vivo in the phosphorylation of RPS6,mediating protein synthesis initiation and elongation induced by hormones or growth factors,maybe playing an essentilal regulatory role in protein synthesis during cell proliferation
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function:
May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell

Enzyme Numbers (IUBMB) for RPS6KC1 Gene

Gene Ontology (GO) - Molecular Function for RPS6KC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005515 protein binding IPI 15750338
GO:0005524 ATP binding IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups --
genes like me logo Genes that share ontologies with RPS6KC1: view

Phenotypes for RPS6KC1 Gene

GenomeRNAi human phenotypes for RPS6KC1:
genes like me logo Genes that share phenotypes with RPS6KC1: view

Animal Model Products

miRNA for RPS6KC1 Gene

miRTarBase miRNAs that target RPS6KC1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPS6KC1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for RPS6KC1 Gene

Localization for RPS6KC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS6KC1 Gene

Cytoplasm. Membrane. Note=Also found in some small dot-like or ring-shaped early endosome structures.

Subcellular locations from

Jensen Localization Image for RPS6KC1 Gene COMPARTMENTS Subcellular localization image for RPS6KC1 gene
Compartment Confidence
endosome 5
cytosol 3
mitochondrion 3
nucleus 2

Gene Ontology (GO) - Cellular Components for RPS6KC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005769 early endosome IDA 15750338
GO:0016020 membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with RPS6KC1: view

Pathways for RPS6KC1 Gene

genes like me logo Genes that share pathways with RPS6KC1: view

Pathways by source for RPS6KC1 Gene

2 Qiagen pathways for RPS6KC1 Gene

Gene Ontology (GO) - Biological Process for RPS6KC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction TAS 10552933
genes like me logo Genes that share ontologies with RPS6KC1: view

Transcripts for RPS6KC1 Gene

Unigene Clusters for RPS6KC1 Gene

Ribosomal protein S6 kinase, 52kDa, polypeptide 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPS6KC1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS6KC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b
SP1: - -
SP2: - - -
SP3: - -

Relevant External Links for RPS6KC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS6KC1 Gene

mRNA expression in normal human tissues for RPS6KC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for RPS6KC1 Gene

This gene is overexpressed in Adipocyte (57.5) and Monocytes (9.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS6KC1 Gene

SOURCE GeneReport for Unigene cluster for RPS6KC1 Gene Hs.591416

mRNA Expression by UniProt/SwissProt for RPS6KC1 Gene

Tissue specificity: Highly expressed in testis, skeletal muscle, brain, heart, placenta, kidney and liver and weakly expressed in thymus, small intestine, lung and colon.
genes like me logo Genes that share expressions with RPS6KC1: view

Expression partners for RPS6KC1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RPS6KC1 Gene

Orthologs for RPS6KC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RPS6KC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPS6KC1 35
  • 90.27 (n)
  • 89.5 (a)
RPS6KC1 36
  • 89 (a)
(Canis familiaris)
Mammalia RPS6KC1 35
  • 92.75 (n)
  • 92.02 (a)
RPS6KC1 36
  • 90 (a)
(Mus musculus)
Mammalia Rps6kc1 35
  • 79.64 (n)
  • 79.1 (a)
Rps6kc1 16
Rps6kc1 36
  • 79 (a)
(Pan troglodytes)
Mammalia RPS6KC1 35
  • 99.81 (n)
  • 99.91 (a)
RPS6KC1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rps6kc1 35
  • 80.52 (n)
  • 79.11 (a)
(Monodelphis domestica)
Mammalia RPS6KC1 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia RPS6KC1 36
  • 75 (a)
(Gallus gallus)
Aves RPS6KC1 35
  • 74.75 (n)
  • 71.79 (a)
RPS6KC1 36
  • 69 (a)
(Anolis carolinensis)
Reptilia RPS6KC1 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rps6kc1 35
  • 65.01 (n)
  • 61.25 (a)
(Danio rerio)
Actinopterygii RPS6KC1 36
  • 48 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001909 35
  • 41.86 (n)
  • 33.9 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7156 35
  • 44.87 (n)
  • 36.14 (a)
CG7156 36
  • 24 (a)
(Caenorhabditis elegans)
Secernentea rskd-1 36
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
Species with no ortholog for RPS6KC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS6KC1 Gene

Gene Tree for RPS6KC1 (if available)
Gene Tree for RPS6KC1 (if available)

Paralogs for RPS6KC1 Gene

Paralogs for RPS6KC1 Gene

Selected SIMAP similar genes for RPS6KC1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RPS6KC1: view

Variants for RPS6KC1 Gene

Sequence variations from dbSNP and Humsavar for RPS6KC1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1009264 -- 213,121,768(-) CCTCC(C/T)CAAAC intron-variant
rs1391549 -- 213,197,784(+) acttt(C/T)ggctt intron-variant
rs1391550 -- 213,158,060(+) AATGT(A/G)TATCT intron-variant
rs1498355 -- 213,171,041(+) AATTA(A/T)TGTTT intron-variant
rs1498356 -- 213,209,241(+) CTGAT(G/T)TAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPS6KC1 Gene

Variant ID Type Subtype PubMed ID
nsv508692 CNV Loss 20534489
esv2675698 CNV Deletion 23128226
esv28931 CNV Loss 19812545
esv1004277 CNV Gain 20482838
esv2666633 CNV Deletion 23128226
nsv826598 CNV Loss 20364138
esv275574 CNV Gain+Loss 21479260
nsv4476 CNV Insertion 18451855
nsv508693 CNV Loss 20534489
esv2671923 CNV Deletion 23128226

Relevant External Links for RPS6KC1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS6KC1 Gene

Disorders for RPS6KC1 Gene

No disorders were found for RPS6KC1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for RPS6KC1 Gene

Publications for RPS6KC1 Gene

  1. Cloning, characterization, and chromosome mapping of RPS6KC1, a novel putative member of the ribosome protein S6 kinase family, to chromosome 12q12-q13.1. (PMID: 10552933) Zhang H. … Zhao S. (Genomics 1999) 2 3 4
  2. Identification and characterization of RPK118, a novel sphingosine kinase-1-binding protein. (PMID: 12077123) Hayashi S. … Nakamura S. (J. Biol. Chem. 2002) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for RPS6KC1 Gene

Sources for RPS6KC1 Gene

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