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RPS6KC1 Gene(Protein Coding)

Ribosomal Protein S6 Kinase C1

GCID:
GC01P213051
GIFtS:
50
Genes Participants
UDN Logo

Aliases for RPS6KC1 Gene

Aliases for RPS6KC1 Gene

  • Ribosomal Protein S6 Kinase C1 2 3
  • Ribosomal S6 Kinase-Like Protein With Two PSK Domains 118 KDa Protein 3 4
  • Ribosomal Protein S6 Kinase, 52kDa, Polypeptide 1 3 5
  • 52 KDa Ribosomal Protein S6 Kinase 3 4
  • SPHK1-Binding Protein 3 4
  • S6K-Delta-1 3 4
  • RPK118 3 4
  • Ribosomal Protein S6 Kinase, 52kD, Polypeptide 1 2
  • EC 2.7.11.1 4
  • HumS6PKh1 3
  • S6PKh1 3
  • RSKL1 3

External Ids for RPS6KC1 Gene

Previous GeneCards Identifiers for RPS6KC1 Gene

  • GC01P212070
  • GC01P209067
  • GC01P209840
  • GC01P210281
  • GC01P209612
  • GC01P211291
  • GC01P213224
  • GC01P183899

Summaries for RPS6KC1 Gene

GeneCards Summary for RPS6KC1 Gene

RPS6KC1 (Ribosomal Protein S6 Kinase C1) is a Protein Coding gene. Among its related pathways are Nanog in Mammalian ESC Pluripotency and CNTF Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein serine/threonine kinase activity. An important paralog of this gene is SNX15.

UniProtKB/Swiss-Prot for RPS6KC1 Gene

  • May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell.

Gene Wiki entry for RPS6KC1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS6KC1 Gene

Genomics for RPS6KC1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for RPS6KC1 Gene

Enhancers for RPS6KC1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPS6KC1 on UCSC Golden Path with GeneCards custom track

Promoters for RPS6KC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPS6KC1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the RPS6KC1 gene promoter:

Genomic Location for RPS6KC1 Gene

Chromosome:
1
Start:
213,051,233 bp from pter
End:
213,274,773 bp from pter
Size:
223,541 bases
Orientation:
Plus strand

Genomic View for RPS6KC1 Gene

Genes around RPS6KC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS6KC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS6KC1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for RPS6KC1 Gene

Proteins for RPS6KC1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for RPS6KC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96S38-KS6C1_HUMAN
    Recommended name:
    Ribosomal protein S6 kinase delta-1
    Protein Accession:
    Q96S38
    Secondary Accessions:
    • B1APS8
    • B3KVM4
    • D3DTA4
    • Q8TDD3
    • Q9NSF4
    • Q9UL66

    Protein attributes for RPS6KC1 Gene

    Size:
    1066 amino acids
    Molecular mass:
    118682 Da
    Quaternary structure:
    • Interacts with SPHK1 and phosphatidylinositol 3-phosphate.
    SequenceCaution:
    • Sequence=CAB92850.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RPS6KC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPS6KC1 Gene

Proteomics data for RPS6KC1 Gene at MOPED

Protein Expression for RPS6KC1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for RPS6KC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPS6KC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPS6KC1 Gene

Domains & Families for RPS6KC1 Gene

Gene Families for RPS6KC1 Gene

IUPHAR :

Protein Domains for RPS6KC1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RPS6KC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96S38

UniProtKB/Swiss-Prot:

KS6C1_HUMAN :
  • The first protein kinase domain appears to be a pseudokinase domain as it does not contain the classical characteristics, such as the ATP-binding motif, ATP-binding site and active site.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. S6 kinase subfamily.
Domain:
  • The first protein kinase domain appears to be a pseudokinase domain as it does not contain the classical characteristics, such as the ATP-binding motif, ATP-binding site and active site.
  • Contains 1 MIT domain.
  • Contains 2 protein kinase domains.
  • Contains 1 PX (phox homology) domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. S6 kinase subfamily.
genes like me logo Genes that share domains with RPS6KC1: view

Function for RPS6KC1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for RPS6KC1 Gene

GENATLAS Biochemistry:
ribosomal protein S6 kinase,polypeptide 1,expressed highly in testis,skeletal muscle,brain and pancreas,not involved in vivo in the phosphorylation of RPS6,mediating protein synthesis initiation and elongation induced by hormones or growth factors,maybe playing an essentilal regulatory role in protein synthesis during cell proliferation
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell.

Enzyme Numbers (IUBMB) for RPS6KC1 Gene

Gene Ontology (GO) - Molecular Function for RPS6KC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0035091 phosphatidylinositol binding IEA --
genes like me logo Genes that share ontologies with RPS6KC1: view

Phenotypes for RPS6KC1 Gene

GenomeRNAi human phenotypes for RPS6KC1:
genes like me logo Genes that share phenotypes with RPS6KC1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RPS6KC1

miRNA for RPS6KC1 Gene

miRTarBase miRNAs that target RPS6KC1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS6KC1 Gene

Localization for RPS6KC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS6KC1 Gene

Cytoplasm. Membrane. Note=Also found in some small dot-like or ring-shaped early endosome structures.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS6KC1 Gene COMPARTMENTS Subcellular localization image for RPS6KC1 gene
Compartment Confidence
endosome 5
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for RPS6KC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RPS6KC1: view

Pathways & Interactions for RPS6KC1 Gene

genes like me logo Genes that share pathways with RPS6KC1: view

Pathways by source for RPS6KC1 Gene

2 Qiagen pathways for RPS6KC1 Gene

Gene Ontology (GO) - Biological Process for RPS6KC1 Gene

None

No data available for SIGNOR curated interactions for RPS6KC1 Gene

Drugs & Compounds for RPS6KC1 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for RPS6KC1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for RPS6KC1 Gene

(10) REFSEQ mRNAs :
(16) Additional mRNA sequences :
(108) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RPS6KC1 Gene

Ribosomal protein S6 kinase, 52kDa, polypeptide 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS6KC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b
SP1: - -
SP2: - - -
SP3: - -
SP4:

Relevant External Links for RPS6KC1 Gene

GeneLoc Exon Structure for
RPS6KC1
ECgene alternative splicing isoforms for
RPS6KC1

Expression for RPS6KC1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for RPS6KC1 Gene

mRNA expression in normal human tissues for RPS6KC1 Gene
mRNA expression by BioGPS for RPS6KC1 GenemRNA expression by GTEx for RPS6KC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPS6KC1 Gene

This gene is overexpressed in Adipocyte (57.5) and Monocytes (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS6KC1 Gene



SOURCE GeneReport for Unigene cluster for RPS6KC1 Gene Hs.591416

mRNA Expression by UniProt/SwissProt for RPS6KC1 Gene

Q96S38-KS6C1_HUMAN
Tissue specificity: Highly expressed in testis, skeletal muscle, brain, heart, placenta, kidney and liver and weakly expressed in thymus, small intestine, lung and colon.
genes like me logo Genes that share expression patterns with RPS6KC1: view

Protein tissue co-expression partners for RPS6KC1 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for RPS6KC1 Gene

Orthologs for RPS6KC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RPS6KC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia RPS6KC1 35
  • 90.27 (n)
  • 89.5 (a)
RPS6KC1 36
  • 89 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia RPS6KC1 35
  • 92.75 (n)
  • 92.02 (a)
RPS6KC1 36
  • 90 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Rps6kc1 35
  • 79.64 (n)
  • 79.1 (a)
Rps6kc1 16
Rps6kc1 36
  • 79 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia RPS6KC1 35
  • 99.81 (n)
  • 99.91 (a)
RPS6KC1 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Rps6kc1 35
  • 80.52 (n)
  • 79.11 (a)
oppossum
(Monodelphis domestica)
 Mammalia RPS6KC1 36
  • 80 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia RPS6KC1 36
  • 75 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves RPS6KC1 35
  • 74.75 (n)
  • 71.79 (a)
RPS6KC1 36
  • 69 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia RPS6KC1 36
  • 68 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia rps6kc1 35
  • 65.01 (n)
  • 61.25 (a)
zebrafish
(Danio rerio)
 Actinopterygii RPS6KC1 36
  • 48 (a)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP001909 35
  • 41.86 (n)
  • 33.9 (a)
fruit fly
(Drosophila melanogaster)
 Insecta CG7156 35
  • 44.87 (n)
  • 36.14 (a)
CG7156 36
  • 24 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea rskd-1 36
  • 20 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 36
  • 28 (a)
 OneToMany
Species with no ortholog for RPS6KC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS6KC1 Gene

ENSEMBL:
Gene Tree for RPS6KC1 (if available)
TreeFam:
Gene Tree for RPS6KC1 (if available)

Paralogs for RPS6KC1 Gene

Paralogs for RPS6KC1 Gene

(4) SIMAP similar genes for RPS6KC1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RPS6KC1: view

Variants for RPS6KC1 Gene

Sequence variations from dbSNP and Humsavar for RPS6KC1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs56087470 - 213,071,024(+) GAAAT(A/C)CAGAG intron-variant, reference, missense, utr-variant-5-prime
rs56032860 - 213,104,477(+) TTATC(A/G)AAGAG reference, missense, utr-variant-5-prime
rs56369827 - 213,176,404(+) GCCTC(C/T)AGGAT intron-variant, reference, missense, utr-variant-5-prime
rs56183862 - 213,240,747(+) AAGTC(C/T)TGAAG reference, missense, utr-variant-5-prime
rs35281247 - 213,241,112(-) AATAG(C/G)TTTTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for RPS6KC1 Gene

Variant ID Type Subtype PubMed ID
nsv508692 CNV Loss 20534489
esv2675698 CNV Deletion 23128226
esv28931 CNV Loss 19812545
esv1004277 CNV Gain 20482838
esv2666633 CNV Deletion 23128226
nsv826598 CNV Loss 20364138
esv275574 CNV Gain+Loss 21479260
nsv4476 CNV Insertion 18451855
nsv508693 CNV Loss 20534489
esv2671923 CNV Deletion 23128226

Variation tolerance for RPS6KC1 Gene

Residual Variation Intolerance Score: 20.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.32; 62.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS6KC1 Gene

HapMap Linkage Disequilibrium report
RPS6KC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS6KC1 Gene

Disorders for RPS6KC1 Gene

Relevant External Links for RPS6KC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPS6KC1

No disorders were found for RPS6KC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPS6KC1 Gene

Publications for RPS6KC1 Gene

  1. Cloning, characterization, and chromosome mapping of RPS6KC1, a novel putative member of the ribosome protein S6 kinase family, to chromosome 12q12-q13.1. (PMID: 10552933) Zhang H. … Zhao S. (Genomics 1999) 2 3 4 67
  2. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for RPS6KC1 Gene

Sources for RPS6KC1 Gene

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