RPS6KB2 Gene
protein-coding GIFtS: 66
GCID: GC11P067195
|
|
ribosomal protein S6 kinase, 70kDa, polypeptide 2(Previous names: ribosomal protein S6 kinase, 70kD, polypeptide 2 )
| |
Aliases
for RPS6KB2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 21 2 | | P70-S6K 22 3 | | STK14B1 2 3 | | S6 Kinase-Related Kinase2 3 | | KLS1 2 | | EC 2.7.11.13 8 | | P70S6Kb1 | | P70-BETA1 | | Serine/Threonine-Protein Kinase 14B2 3 | | Ribosomal Protein S6 Kinase, 70kD, Polypeptide 21 | | 70 KDa Ribosomal Protein S6 Kinase 22 3 | | P70-Beta1 | | P70S6K22 3 | | P70-Beta-11 | | S6K-Beta1 | | P70-Beta-21 | | S6K-Beta-21 | | S6K-Beta21 | | S6K22 3 | | P70(S6K)-Beta1 | | SRK2 3 | | Ribosomal Protein S6 Kinase Beta-22 | | P70 Ribosomal S6 Kinase Beta2 3 | | Serine/Threonine-Protein Kinase 14 Beta2 | | P70 S6 Kinase Beta2 3 | | P70-Beta1 | | P70 S6K-Beta2 3 | | EC 2.7.118 | | P70 S6KB2 3 | | |
Export aliases for RPS6KB2 gene to outside databasesPrevious GC identifers: GC11P069692 GC11P068892 GC11P067445 GC11P066971 GC11P066932 GC11P066952 GC11P063523 |
Summaries
for RPS6KB2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RPS6KB2:
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translationinitiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.(provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: KS6B2_HUMAN, Q9UBS0Function: Phosphorylates specifically ribosomal protein S6
Gene Wiki entry for RPS6KB2
|
Genomic Views
for RPS6KB2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RPS6KB2 gene promoter:
p53 Bach2 GATA-2 CREB HEN1 Max deltaCREB Sox9 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for RPS6KB2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS6KB2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13.2 Ensembl cytogenetic band: 11q13.2 HGNC cytogenetic band: 11q13.1RPS6KB2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P067195: view genomic region
(about GC identifiers)
Start:
|
67,195,931 bp from pter |
End:
|
67,202,879 bp from pter |
Size:
|
6,949 bases |
Orientation:
|
plus strand |
|
Proteins
for RPS6KB2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KS6B2_HUMAN, Q9UBS0 (See
protein sequence)Recommended Name: Ribosomal protein S6 kinase beta-2 Size: 482 amino acids; 53455 Da
Subcellular location: Cytoplasm. Nucleus
Sequence caution: Sequence=BAA34402.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B2RMZ9 O94809 Q9UEC1Explore the universe of human proteins at neXtProt for RPS6KB2: NX_Q9UBS0
Post-translational modifications:
Phosphorylated and activated by MTOR. Phosphorylation by PKC within the NLS in response to mitogenic stimuli causescytoplasmic retention1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UBS0
4/20 DME Specific Peptides for RPS6KB2 (Q9UBS0) (see all 20)
RPS6KB2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003943.2
ENSEMBL proteins: ENSP00000435716 ENSP00000450621 ENSP00000436811 ENSP00000431615 ENSP00000410175 ENSP00000308413 ENSP00000432847 ENSP00000442949 Reactome Protein details: Q9UBS0
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
RPS6KB2 for ontologies About GeneDecksing
RPS6KB2 Antibody Products:
Assay Products for RPS6KB2: |
Protein
Domains /
Families
for RPS6KB2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RPS6KB2 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q9UBS0ProtoNet protein and cluster: Q9UBS0 1 Blocks protein family: IPB000961 Protein kinase C-terminal domain
UniProtKB/Swiss-Prot: KS6B2_HUMAN, Q9UBS0Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamilySimilarity: Contains 1 AGC-kinase C-terminal domainSimilarity: Contains 1 protein kinase domain |
Function
for RPS6KB2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KS6B2_HUMAN, Q9UBS0Function: Phosphorylates specifically ribosomal protein S6Catalytic activity: ATP + a protein = ADP + a phosphoprotein Genatlas biochemistry entry for RPS6KB2:ribosomal protein S6 kinase,70kDa,polypeptide 2,widely expressed,not involved in vivo in the phosphorylation ofRPS6,mediating protein synthesis initiation and elongation induced by hormones or growth factors,maybe playing anessential regulatory role in protein synthesis during cell proliferation
Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Inhib. RNA
Products: |  | EMD Millipore RNAi Products for the Analysis of RPS6KB2 Gene knock-down | |  | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPS6KB2 (see all 7)
OriGene shRNA RFP: RPS6KB2
OriGene siRNA: RPS6KB2
| | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS6KB2 |
Clone
Products: | | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPS6KB2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPS6KB2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RPS6KB2 (NM_003952) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPS6KB2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS6KB2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS6KB2 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
RPS6KB2 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for RPS6KB2:
Animal Models:
Mouse knock-out Rps6kb2tm1Gtho for RPS6KB2
8 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Rps6kb2):
RPS6KB2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for RPS6KB2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/22 super-pathways (see all 22) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by FGFR | | | 2 | Development_CNTF receptor signaling | | | 3 | PIP3 activates AKT signaling | | | 4 | Immune System | | | 5 | Translation_Translation regulation by Alpha-1 adrenergic receptors | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/8 EMD Millipore Pathways for RPS6KB2 (see all 8)
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RPS6KB2
5/8  GeneGo (Thomson Reuters) Pathways for RPS6KB2 (see all 8)
5  BioSystems Pathways for RPS6KB2
5/30 
Reactome Pathways for RPS6KB2 (see all 30)
5/6 
Kegg Pathways (Kegg details for RPS6KB2) (see all 6):
RPS6KB2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RPS6KB2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/762 Interacting proteins for RPS6KB2 (Q9UBS02, 3 ENSP000003084134) via UniProtKB, MINT, STRING, and/or I2D (see all 762)About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table
RPS6KB2 for ontologies About GeneDecksing
|
Drugs & Compounds
for RPS6KB2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
RPS6KB2 for compounds About GeneDecksing
 Browse Tocris compounds for RPS6KB2
2 HMDB Compounds for RPS6KB2 About this table
6 Novoseek chemical compound relationships for RPS6KB2 gene About this table
Search CenterWatch for drugs/clinical trials and news about RPS6KB2 / KS6B2
|
Transcripts
for RPS6KB2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RPS6KB2 gene (2 alternative transcripts): NM_003952.2 NM_001007071.1 Unigene Cluster for RPS6KB2: Ribosomal protein S6 kinase, 70kDa, polypeptide 2 Hs.534345 [show with all ESTs]Unigene Representative Sequence: BC00009413 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000530623 ENST00000556575 ENST00000524934 ENST00000524814 ENST00000420069
ENST00000312629(uc001old.3) ENST00000528964 ENST00000525088(uc021qmi.1)
ENST00000525996 ENST00000525726 ENST00000526268 ENST00000531765 ENST00000539188
Inhib. RNA
Products: | | EMD Millipore RNAi Products for the Analysis of RPS6KB2 Gene knock-down | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPS6KB2 (see all 7)
OriGene shRNA RFP: RPS6KB2
OriGene siRNA: RPS6KB2
| | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS6KB2 |
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPS6KB2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPS6KB2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RPS6KB2 (NM_003952) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPS6KB2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS6KB2 |
Additional cDNA sequence: AB016869.1 AB019245.1 AF076931.1 AF099739.1 AK297527.1 BC000094.2 BC006106.1 BC136564.1 BX538119.1 13 DOTS entries: DT.112590 DT.100698514 DT.40237947 DT.100828823 DT.75198876 DT.100654415 DT.120719175 DT.95348289 DT.100828827 DT.120719178 DT.100828828 DT.120719177 DT.95327360 24/364 AceView cDNA sequences (see all 364): BQ961675 BM423942 CR593441 BX401752 BG254660 BM915476 BM785159 BM853302 CR622954 BE882270 BI793022 BQ059474 BM700496 CR613481 CR605830 BM804913 BM829873 BU517144 CB991953 BI836595 BQ431606 CR618047 BX472608 AI338501
GeneLoc Exon Structure
5/17 Alternative Splicing Database (ASD) splice patterns (SP) for RPS6KB2 (see all 17) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | - | | - | | - | | | | | | | | | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 16 | ^ | 17a | · | 17b |
|---|
|
| SP1: | | | | | | | |
| SP2: | | | | | | | |
| SP3: | | | | | | | |
| SP4: | | | | | | | |
| SP5: | | | | | | |
ECgene alternative splicing isoforms for RPS6KB2
|
Expression
for RPS6KB2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RPS6KB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGCTGAAAA
About this image
See RPS6KB2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RPS6KB2
SOURCE GeneReport for Unigene cluster: Hs.534345
SABiosciences Expression via Pathway-Focused PCR Array including RPS6KB2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPS6KB2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RPS6KB2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS6KB2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS6KB2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS6KB2 |
Orthologs
for RPS6KB2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RPS6KB2 gene from 5/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
RPS6KB26 |
-- |
84(a) |
1 ↔ 1 |
1(93292206-93309952) |
fruit fly
(Drosophila melanogaster) |
Insecta |
S6k3 |
cell growth and/or maintenance protein
serine/threonine more |
72(a)
(best of 2) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
Y47D3A.163 |
ribosomal protein S6 kinase |
57(a)
(best of 3) |
|
III(11316958-11322832) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
ATPK16S6K26 |
serine/threonine protein kinase 2 |
32(a)32(a) |
many ↔ manymany ↔ many |
3(2651447-2654212) 3(2648509-2651160) |
rice
(Oryza sativa) |
Liliopsida |
---- |
AGC_AGC_other_RS6K_like.1 - ACG kinases include ho...AGC_AGC_other_RS6K_like.2 - ACG kinases include ho... |
32(a)31(a) |
many ↔ manymany ↔ many |
3(12338898-12343059) 7(28854803-28858816) |
ENSEMBL Gene Tree for RPS6KB2 (if available)
TreeFam Gene Tree for RPS6KB2 (if available) |
Paralogs
for RPS6KB2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RPS6KB2 gene
- AKT12 RPS6KA62 RPS6KB12 SGK32 SGK22 RPS6KA12 AKT32 RPS6KA52
- RPS6KA42 SGK12 RPS6KA22 AKT22 RPS6KA32
18/52 SIMAP similar genes for RPS6KB2 using alignment to 7 protein entries: KS6B2_HUMAN (see all proteins)
(see all similar genes):RPS6KB1 RPS6KA2 RPS6KA5 KIN27 RPS6KA6 PRKACA
RPS6KA3 RPS6KA4 PRKCI SGK2 PRKG1 SGK3
PRKACB DKFZp781N0293 PRKACG SGKL RPS6KA1 PRKCZ
RPS6KB2 for paralogs About GeneDecksing
|
Genomic Variants
for RPS6KB2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RPS6KB2 (67195931 - 67202879 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RPS6KB2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPS6KB2 |
|
Disorders
/ Diseases
for RPS6KB2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RPS6KB2 for disorders About GeneDecksing
OMIM gene information: 608939
OMIM disorders: --
17  diseases for RPS6KB2: About MalaCardslandau-kleffner syndrome coffin-lowry syndrome recurrent hypersomnia hypersomnia
sensenbrenner syndrome acute myeloid leukemia myeloid leukemia craniosynostosis
endometrial adenocarcinoma lung cancer gout adenocarcinoma
alzheimer's disease pharyngitis leukemia breast cancer
ischemia
2 diseases from the University of Copenhagen DISEASES database for RPS6KB2:Kleine-Levin syndrome Landau-Kleffner syndrome 4 Novoseek disease relationships for RPS6KB2 gene About this table
Human Genome Epidemiology (HuGE) Navigator: RPS6KB2 (4 documents)
Export disorders for RPS6KB2 gene to outside databases
|
Publications
for RPS6KB2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RPS6KB2 gene, integrated from 9 sources (see all 56):
(articles sorted by number of sources associating them with RPS6KB2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region. (PubMed id 9804755)1, 2, 3, 9 Gout I.... Yonezawa K. (1998)
- Cloning and characterization of p70 S6Kbeta defines a novel family of p70 S6 kinases. (PubMed id 9878560)1, 2, 3 Saitoh M.... Ichijo H. (1998)
- Regulation of ribosomal S6 kinase 2 by mammalian target of rapamycin. (PubMed id 12087098)1, 2, 9 Park I.H....Chen J. (2002)
- Characterization of S6K2, a novel kinase homologous to S6K1. (PubMed id 10490847)1, 2, 9 Lee-Fruman K.K.... Blenis J. (1999)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Protein kinase C phosphorylates ribosomal protein S6 kinase betaII and regulates its subcellular localization. (PubMed id 12529391)1, 2 Valovka T....Gout I.T. (2003)
- Cloning and characterization of a nuclear S6 kinase, S6 kinase-related kinase (SRK); a novel nuclear target of Akt. (PubMed id 10490848)1, 9 Koh H....Chung J. (1999)
- Mutational analysis of ribosomal S6 kinase 2 shows differential regulation of its kinase activity from that of ribosomal S6 kinase 1. (PubMed id 12713446)1, 9 Phin S....Lee-Fruman K.K. (2003)
- Ribosomal S6 kinase 2 inhibition by a potent C-terminal repressor domain is relieved by mitogen-activated protein-extracellular signal-regulated kinase kinase-regulated phosphorylation. (PubMed id 11108720)1, 9 Martin K.A....Blenis J. (2001)
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External Searches for RPS6KB2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing RPS6KB2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing RPS6KB2 gene
(According to HUGE)
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Specialized Databases showing RPS6KB2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for RPS6KB2 gene:
Search GeneIP for patents involving RPS6KB2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for RPS6KB2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for RPS6KB2 | | OriGene shRNA RFP for RPS6KB2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPS6KB2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPS6KB2 | | | OriGene Protein Over-expression Lysate for RPS6KB2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RPS6KB2 | | OriGene 3'-UTR Clone for RPS6KB2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPS6KB2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPS6KB2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RPS6KB2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RPS6KB2 | | OriGene Custom Protein Services for RPS6KB2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RPS6KB2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPS6KB2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS6KB2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS6KB2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS6KB2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS6KB2 |
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| | | | Search Tocris compounds for RPS6KB2 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS6KB2 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS6KB2 |
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