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RPS6KB2 Gene

protein-coding   GIFtS: 74
GCID: GC11P067195

Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2

(Previous names: ribosomal protein S6 kinase, 70kD, polypeptide 2)
  See RPS6KB2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 21 2     S6 Kinase-Related Kinase2 3
Serine/Threonine-Protein Kinase 14B2 3     EC 2.7.11.13 8
70 KDa Ribosomal Protein S6 Kinase 22 3     Ribosomal Protein S6 Kinase, 70kD, Polypeptide 21
P70S6K22 3     KLS2
S6K-beta2 3     P70-beta2
S6K-beta-22 3     P70-beta-12
S6K22 3     P70-beta-22
SRK2 3     S6K-beta22
STK14B2 3     p70(S6K)-beta2
P70 Ribosomal S6 Kinase Beta2 3     p70S6Kb2
P70 S6 Kinase Beta2 3     Ribosomal Protein S6 Kinase Beta-22
P70 S6K-Beta2 3     Serine/Threonine-Protein Kinase 14 Beta2
P70 S6KB2 3     p70-beta3
P70-S6K 22 3     EC 2.7.118

External Ids:    HGNC: 104371   Entrez Gene: 61992   Ensembl: ENSG000001756347   OMIM: 6089395   UniProtKB: Q9UBS03   
ORGUL members:         

Export aliases for RPS6KB2 gene to outside databases

Previous GC identifers: GC11P069692 GC11P068892 GC11P067445 GC11P066971 GC11P066932 GC11P066952 GC11P063523


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RPS6KB2 Gene:
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase
contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic
translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and
cell proliferation. (provided by RefSeq, Jul 2008)

GeneCards Summary for RPS6KB2 Gene:
RPS6KB2 (ribosomal protein S6 kinase, 70kDa, polypeptide 2) is a protein-coding gene. Diseases associated with RPS6KB2 include landau-kleffner syndrome, and kleine-levin syndrome. GO annotations related to this gene include protein serine/threonine kinase activity and peptide binding. An important paralog of this gene is AKT1.

UniProtKB/Swiss-Prot: KS6B2_HUMAN, Q9UBS0
Function: Phosphorylates specifically ribosomal protein S6

Gene Wiki entry for RPS6KB2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPS6KB2 gene promoter:
         p53   Bach2   GATA-2   CREB   HEN1   Max   deltaCREB   Sox9   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPS6KB2 promoter sequence
   Search Chromatin IP Primers for RPS6KB2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPS6KB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.2   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13.1

RPS6KB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS6KB2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P067195:  view genomic region     (about GC identifiers)

Start:
67,195,931 bp from pter      End:
67,202,879 bp from pter
Size:
6,949 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KS6B2_HUMAN, Q9UBS0 (See protein sequence)
Recommended Name: Ribosomal protein S6 kinase beta-2  
Size: 482 amino acids; 53455 Da
Sequence caution: Sequence=BAA34402.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B2RMZ9 O94809 Q9UEC1

Explore the universe of human proteins at neXtProt for RPS6KB2: NX_Q9UBS0

Explore proteomics data for RPS6KB2 at MOPED

Post-translational modifications: 

  • Phosphorylated and activated by MTOR. Phosphorylation by PKC within the NLS in response to mitogenic stimuli
    causes cytoplasmic retention1
  • Ubiquitination2 at Lys80
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for RPS6KB2 (Q9UBS0) (see all 20)
     YMAPEIL  GHIKLTD  LGKGGYG  DFGLCKE 


    See RPS6KB2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003943.2  
    ENSEMBL proteins: 
     ENSP00000435716   ENSP00000450621   ENSP00000436811   ENSP00000410175   ENSP00000308413  
     ENSP00000432847   ENSP00000473485   ENSP00000442949  
    Reactome Protein details: Q9UBS0

    RPS6KB2 Human Recombinant Protein Products:

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    Novus Biologicals RPS6KB2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for RPS6KB2 

     
    antibodies-online proteins for RPS6KB2 (7 products) 

     
    antibodies-online peptides for RPS6KB2

    RPS6KB2 Antibody Products:

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    antibodies-online antibodies for RPS6KB2 (195 products) 

    RPS6KB2 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: ribosomal protein S6 kinase, 70kDa, polypeptide 2
    p70 subfamily
    Other AGC kinases

    Selected InterPro protein domains (see all 8):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR016238 Ribosomal_S6_kinase
     IPR000961 AGC-kinase_C
     IPR011009 Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9UBS0

    ProtoNet protein and cluster: Q9UBS0

    1 Blocks protein domain: IPB000961 Protein kinase C-terminal domain

    UniProtKB/Swiss-Prot: KS6B2_HUMAN, Q9UBS0
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with RPS6KB2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KS6B2_HUMAN, Q9UBS0
    Function: Phosphorylates specifically ribosomal protein S6
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Genatlas biochemistry entry for RPS6KB2:
    ribosomal protein S6 kinase,70kDa,polypeptide 2,widely expressed,not involved in vivo in the phosphorylation of
    RPS6,mediating protein synthesis initiation and elongation induced by hormones or growth factors,maybe playing an
    essential regulatory role in protein synthesis during cell proliferation

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS9804755
    GO:0004674protein serine/threonine kinase activity TAS9878560
    GO:0004711ribosomal protein S6 kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with RPS6KB2           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for RPS6KB2:
     Decreased Wnt reporter activit  Decreased viability with RAF26  Increased telomerase activity 

         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rps6kb2):
     cardiovascular system  cellular  growth/size/body  homeostasis/metabolism  mortality/aging 
     muscle  normal  reproductive system 

    Find genes that share phenotypes with RPS6KB2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rps6kb2tm1Gtho for RPS6KB2

       genOway: Develop your customized and physiologically relevant rodent model for RPS6KB2

    miRNA
    Products:
        
    miRTarBase miRNAs that target RPS6KB2:
    hsa-mir-26b-5p (MIRT029811), hsa-mir-98-5p (MIRT027691), hsa-mir-1296-5p (MIRT036102)

    Block miRNA regulation of human, mouse, rat RPS6KB2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate RPS6KB2
    SwitchGear 3'UTR luciferase reporter plasmidRPS6KB2 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPS6KB2
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    Addgene plasmids for RPS6KB2 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS6KB2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KS6B2_HUMAN, Q9UBS0: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IEA--
    GO:0005840ribosome ----

    Find genes that share ontologies with RPS6KB2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RPS6KB2 About   (see all 26)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Translation Insulin regulation of translation
    Translation Insulin regulation of translation0.59
    Development CNTF receptor signaling0.43
    Regulation of lipid metabolism Insulin signaling generic cascades0.59
    mTOR signaling pathway0.34
    Transcription Receptor mediated HIF regulation0.51
    Insulin signaling pathway0.32
    Translation Regulation activity of EIF4F0.44
    2PI-3K cascade
    PI3K/AKT activation0.93
    PI3K events in ERBB4 signaling0.88
    GAB1 signalosome0.93
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    Constitutive PI3K/AKT Signaling in Cancer0.88
    Signaling by SCF-KIT0.72
    PIP3 activates AKT signaling0.88
    Signaling by ERBB40.66
    3Signaling by FGFR
    Signaling by FGFR0.91
    DAP12 interactions0.89
    Signaling by FGFR in disease0.91
    Signaling by PDGF0.87
    Downstream signaling of activated FGFR0.91
    Signaling by EGFR0.83
    Downstream signal transduction0.90
    Signaling by EGFR in Cancer0.82
    4Downstream Signaling Events Of B Cell Receptor (BCR)
    Downstream Signaling Events Of B Cell Receptor (BCR)0.79
    Signaling by the B Cell Receptor (BCR)0.79
    5Translation Translation regulation by Alpha 1 adrenergic receptors
    Translation Translation regulation by Alpha 1 adrenergic receptors0.64


    Find genes that share SuperPaths with RPS6KB2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for RPS6KB2
        Akt Signaling Pathway

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RPS6KB2
        FLT3 Signaling
    14-3-3 Induced Intracellular Signaling

    Selected GeneGo (Thomson Reuters) Pathways for RPS6KB2 (see all 8)
        Apoptosis and survival BAD phosphorylation
    Translation Insulin regulation of translation
    Development Endothelin-1/EDNRA transactivation of EGFR
    Development CNTF receptor signaling
    Transcription Receptor-mediated HIF regulation

    Selected BioSystems Pathways for RPS6KB2 (see all 6)
        Insulin Signaling
    AMPK signaling
    Cytoplasmic Ribosomal Proteins
    IL-3 Signaling Pathway
    IL-2 Signaling pathway


    2 Reactome Pathways for RPS6KB2
        AKT phosphorylates targets in the nucleus
    Constitutive PI3K/AKT Signaling in Cancer


    Selected Kegg Pathways  (Kegg details for RPS6KB2) (see all 9):
        ErbB signaling pathway
    HIF-1 signaling pathway
    mTOR signaling pathway
    PI3K-Akt signaling pathway
    TGF-beta signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Array including RPS6KB2: 
              mTOR Signaling in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RPS6KB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPS6KB2 (Q9UBS02, 3 ENSP000003084134) via UniProtKB, MINT, STRING, and/or I2D (see all 829)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EEF2KO004182, 3, ENSP000002630264MINT-15495 I2D: score=2 STRING: ENSP00000263026
    COASYQ130572, 3MINT-51121 I2D: score=3 
    MAPK8IP2Q133872, 3MINT-8262591 I2D: score=2 
    RPS6P627532, 3, ENSP000003697574MINT-2833483 I2D: score=2 STRING: ENSP00000369757
    CDC5LQ994592, ENSP000003605324MINT-7945693 MINT-7947479 STRING: ENSP00000360532
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    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation TAS9804755
    GO:0006468protein phosphorylation ----
    GO:0007165signal transduction TAS9804755
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0008543fibroblast growth factor receptor signaling pathway TAS--

    Find genes that share ontologies with RPS6KB2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPS6KB2 (KS6B2)

    2 HMDB Compounds for RPS6KB2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    6 Novoseek inferred chemical compound relationships for RPS6KB2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rapamycin 76.7 16 12713446 (2), 11108711 (1), 17678899 (1), 10490848 (1) (see all 10)
    wortmannin 64.7 6 17678899 (1), 10490848 (1), 10490847 (1), 12713446 (1)
    threonine 51 5 12713446 (3), 11108720 (1)
    phosphatidylinositol 40.8 1 12087098 (1)
    serine 38 5 12713446 (3), 11108720 (1)
    phosphoinositide 31.2 4 12713446 (2), 11108711 (1)



    Find genes that share compounds with RPS6KB2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RPS6KB2 gene (2 alternative transcripts): 
    NM_003952.2  NM_001007071.1  

    Unigene Cluster for RPS6KB2:

    Ribosomal protein S6 kinase, 70kDa, polypeptide 2
    Hs.534345  [show with all ESTs]
    Unigene Representative Sequence: BC000094
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000530623 ENST00000556575 ENST00000524934 ENST00000524814 ENST00000420069
    ENST00000312629(uc001old.3) ENST00000528964 ENST00000525088(uc021qmi.1)
    ENST00000525996 ENST00000525726 ENST00000526268 ENST00000531765 ENST00000539188

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      QuantiTect SYBR Green Assays in human, mouse, rat RPS6KB2
      QuantiFast Probe-based Assays in human, mouse, rat RPS6KB2

    Additional mRNA sequence: 

    AB016869.1 AB019245.1 AF076931.1 AF099739.1 AK297527.1 BC000094.2 BC006106.1 BC136564.1 
    BX538119.1 

    13 DOTS entries:

    DT.112590  DT.100698514  DT.40237947  DT.100828823  DT.75198876  DT.100654415  DT.120719175  DT.95348289 
    DT.100828827  DT.120719178  DT.100828828  DT.120719177  DT.95327360 

    Selected AceView cDNA sequences (see all 364):

    BX336325 BQ072582 BU931869 BQ052262 BX093439 CR597985 BX380495 CR616474 
    BE792760 BX332117 CR593942 CR604258 BQ059474 CR605830 BI793022 BQ961675 
    BM561338 BX381976 BU740300 BX538119 AI338501 BM853302 BQ431606 BU169829 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RPS6KB2 (see all 17)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^
    SP1:                                                        -     -     -                                                           -                           
    SP2:                                                        -     -     -                                                     -     -                           
    SP3:                                                        -     -     -                             -                                                         
    SP4:                                                        -     -     -                 -     -     -                             -                           
    SP5:                                                        -                                                                                                   

    ExUns: 16 ^ 17a · 17b
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for RPS6KB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RPS6KB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCTGAAAA
    RPS6KB2 Expression
    About this image


    RPS6KB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    RPS6KB2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPS6KB2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.534345
        Pathway & Disease-focused RT2 Profiler PCR Array including RPS6KB2: 
              mTOR Signaling in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RPS6KB2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rps6kb21 , 5 ribosomal protein S6 kinase, polypeptide 21, 5 88.38(n)1
    92.95(a)1
      19 (3.86 cM)5
    589881  NM_021485.21  NP_067460.11 
     41567135 
    chicken
    (Gallus gallus)
    Aves RPS6KB26
    ribosomal protein S6 kinase, 70kDa, polypeptide 2
    90(a)
    1 ↔ 1
    AADN03022745.1(21-1265)
    lizard
    (Anolis carolinensis)
    Reptilia RPS6KB26
    ribosomal protein S6 kinase, 70kDa, polypeptide 2
    76(a)
    1 ↔ 1
    1(93292206-93310690)
    fruit fly
    (Drosophila melanogaster)
    Insecta S6k3 cell growth and/or maintenance protein
    serine/threonine more
    72(a)
    (best of 2)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea Y47D3A.163 ribosomal protein S6 kinase 57(a)
    (best of 3)
      III(11316958-11322832)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SCH91 SCH9 52.72(n)
    49.85(a)
      856612   NP_012075.1 


    ENSEMBL Gene Tree for RPS6KB2 (if available)
    TreeFam Gene Tree for RPS6KB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RPS6KB2 gene
    AKT12  GRK72  RPS6KB12  GRK12  SGK32  GRK42  GRK62  C8orf44-SGK32  
    SGK22  ADRBK22  AKT32  SGK12  GRK52  ADRBK12  AKT22  
    Selected SIMAP similar genes for RPS6KB2 using alignment to 7 protein entries:     KS6B2_HUMAN (see all proteins) (see all similar genes):
    RPS6KB1    RPS6KA2    RPS6KA3    KIN27    RPS6KA5    RPS6KA6
    RPS6KA4    PRKCI    SGK2    SGK3    PRKACA    PRKACB
    RPS6KA1    PRKCZ    PRKG1    DKFZp781N0293    PRKACG    SGKL

    Find genes that share paralogs with RPS6KB2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RPS6KB2 (see all 268)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0406464
    An ovarian mucinous carcinoma sample4--see VAR_0406462 T M mis40--------
    rs1919079151,2
    --67193982(+) TCAAGC/TGATTT 1 -- us2k10--------
    rs1816242751,2
    --67194040(+) ACTCCC/TGGCTA 1 -- us2k10--------
    rs1167577561,2
    F--67194329(+) CTCCCC/TTCTAA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1858453861,2
    --67194393(+) CATTCC/TAGTTA 1 -- us2k10--------
    rs122251351,2
    H--67194505(+) cctgtC/Ttgaaa 1 -- us2k14Minor allele frequency- T:0.00NS EA 420
    rs124205261,2
    H--67194585(+) tttaaA/Gatgga 1 -- us2k10--------
    rs112277931,2
    C,A--67194593(+) GGAGTT/CTCGCT 1 -- us2k12Minor allele frequency- C:0.00NA 4
    rs1902542291,2
    C--67194595(+) AGTCTC/TGCTCT 1 -- us2k10--------
    rs1823844581,2
    C--67194720(+) CACCAA/CCATGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RPS6KB2 (67195931 - 67202879 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for RPS6KB2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv468604CNV Loss19166990
    dgv1195n71CNV Loss21882294
    nsv897797CNV Loss21882294
    nsv521723CNV Loss19592680
    nsv897811CNV Loss21882294
    nsv524096CNV Loss19592680
    dgv1194n71CNV Loss21882294
    dgv1193n71CNV Loss21882294
    nsv897801CNV Loss21882294
    nsv897804CNV Gain21882294

    Human Gene Mutation Database (HGMD): RPS6KB2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RPS6KB2
    DNA2.0 Custom Variant and Variant Library Synthesis for RPS6KB2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608939    OMIM disorders: --

    3 diseases for RPS6KB2:    
    About MalaCards
    landau-kleffner syndrome    kleine-levin syndrome    coffin-lowry syndrome

    2 diseases from the University of Copenhagen DISEASES database for RPS6KB2:
    Kleine-Levin syndrome     Landau-Kleffner syndrome

    Find genes that share disorders with RPS6KB2           About GenesLikeMe

    4 Novoseek inferred disease relationships for RPS6KB2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    small cell lung cancer 30.8 1 16810323 (1)
    adenocarcinoma 15.9 3 15627062 (2), 15112576 (1)
    tumors 0 10 15627062 (4), 15112576 (3), 15995633 (1)
    cancer 0 6 15995633 (2), 15112576 (1), 15627062 (1)

    Genetic Association Database (GAD): RPS6KB2
    Human Genome Epidemiology (HuGE) Navigator: RPS6KB2 (4 documents)

    Export disorders for RPS6KB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RPS6KB2 gene, integrated from 10 sources (see all 61):
    (articles sorted by number of sources associating them with RPS6KB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region. (PubMed id 9804755)1, 2, 3, 9 Gout I.... Yonezawa K. (J. Biol. Chem. 1998)
    2. Cloning and characterization of p70 S6Kbeta defines a novel family of p70 S6 kinases. (PubMed id 9878560)1, 2, 3 Saitoh M.... Ichijo H. (Biochem. Biophys. Res. Commun. 1998)
    3. Regulation of ribosomal S6 kinase 2 by mammalian target of rapamycin. (PubMed id 12087098)1, 2, 9 Park I.H.... Chen J. (J. Biol. Chem. 2002)
    4. Characterization of S6K2, a novel kinase homologous to S6K1. (PubMed id 10490847)1, 2, 9 Lee-Fruman K.K.... Blenis J. (Oncogene 1999)
    5. Genetic variation in RPS6KA1, RPS6KA2, RPS6KB1, RPS6KB2, and PDK1 and risk of colon or rectal cancer. (PubMed id 21035469)1, 4 Slattery M.L....Wolff R.K. (Mutat. Res. 2011)
    6. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (Carcinogenesis 2010)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Protein kinase C phosphorylates ribosomal protein S6 kinase betaII and regulates its subcellular localization. (PubMed id 12529391)1, 2 Valovka T.... Gout I.T. (Mol. Cell. Biol. 2003)
    10. Cloning and characterization of a nuclear S6 kinase, S6 kinase-related kinase (SRK); a novel nuclear target of Akt. (PubMed id 10490848)1, 9 Koh H....Chung J. (Oncogene 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6199 HGNC: 10437 AceView: RPS6KB2andKIAA1394 Ensembl:ENSG00000175634 euGenes: HUgn6199
    ECgene: RPS6KB2 Kegg: 6199 H-InvDB: RPS6KB2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RPS6KB2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RPS6KB2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RPS6KB2 gene:
    Search GeneIP for patents involving RPS6KB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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