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Aliases for RPS6KB2 Gene

Aliases for RPS6KB2 Gene

  • Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2 2 3
  • 70 KDa Ribosomal Protein S6 Kinase 2 3 4
  • Serine/Threonine-Protein Kinase 14B 3 4
  • P70 Ribosomal S6 Kinase Beta 3 4
  • S6 Kinase-Related Kinase 3 4
  • P70 S6 Kinase Beta 3 4
  • P70 S6K-Beta 3 4
  • EC 2.7.11.1 4 63
  • S6K-Beta-2 3 4
  • P70-S6K 2 3 4
  • P70 S6KB 3 4
  • P70-Beta 3 4
  • S6K-Beta 3 4
  • P70S6K2 3 4
  • STK14B 3 4
  • S6K2 3 4
  • SRK 3 4
  • Ribosomal Protein S6 Kinase, 70kD, Polypeptide 2 2
  • Serine/Threonine-Protein Kinase 14 Beta 3
  • P70(S6K)-Beta 3
  • P70-Beta-1 3
  • P70-Beta-2 3
  • S6K-Beta2 3
  • EC 2.7.11 63
  • P70S6Kb 3
  • KLS 3

External Ids for RPS6KB2 Gene

Previous GeneCards Identifiers for RPS6KB2 Gene

  • GC11P069692
  • GC11P068892
  • GC11P067445
  • GC11P066971
  • GC11P066932
  • GC11P066952
  • GC11P067195
  • GC11P063523

Summaries for RPS6KB2 Gene

Entrez Gene Summary for RPS6KB2 Gene

  • This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains a kinase catalytic domain and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. [provided by RefSeq, Jan 2015]

GeneCards Summary for RPS6KB2 Gene

RPS6KB2 (Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2) is a Protein Coding gene. Diseases associated with RPS6KB2 include recurrent hypersomnia and kleine-levin syndrome. Among its related pathways are PI3K-Akt signaling pathway and PI3K/AKT Signaling in Cancer. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AKT1.

UniProtKB/Swiss-Prot for RPS6KB2 Gene

  • Phosphorylates specifically ribosomal protein S6

Gene Wiki entry for RPS6KB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS6KB2 Gene

Genomics for RPS6KB2 Gene

Regulatory Elements for RPS6KB2 Gene

Genomic Location for RPS6KB2 Gene

Chromosome:
11
Start:
67,428,460 bp from pter
End:
67,435,408 bp from pter
Size:
6,949 bases
Orientation:
Plus strand

Genomic View for RPS6KB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPS6KB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS6KB2 Gene

Proteins for RPS6KB2 Gene

  • Protein details for RPS6KB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBS0-KS6B2_HUMAN
    Recommended name:
    Ribosomal protein S6 kinase beta-2
    Protein Accession:
    Q9UBS0
    Secondary Accessions:
    • B2RMZ9
    • B4DML8
    • O94809
    • Q9UEC1

    Protein attributes for RPS6KB2 Gene

    Size:
    482 amino acids
    Molecular mass:
    53455 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA34402.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for RPS6KB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPS6KB2 Gene

Proteomics data for RPS6KB2 Gene at MOPED

Post-translational modifications for RPS6KB2 Gene

  • Phosphorylated and activated by MTOR. Phosphorylation by PKC within the NLS in response to mitogenic stimuli causes cytoplasmic retention.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPS6KB2 Gene

Antibody Products

  • R&D Systems Antibodies for RPS6KB2 (p70 S6 Kinase beta)
  • Cell Signaling Technology (CST) Antibodies for RPS6KB2 (P70S6KB)
  • Cloud-Clone Corp. Antibodies for RPS6KB2

Domains & Families for RPS6KB2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UBS0

UniProtKB/Swiss-Prot:

KS6B2_HUMAN :
  • Contains 1 AGC-kinase C-terminal domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
Domain:
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
genes like me logo Genes that share domains with RPS6KB2: view

Function for RPS6KB2 Gene

Molecular function for RPS6KB2 Gene

GENATLAS Biochemistry:
ribosomal protein S6 kinase,70kDa,polypeptide 2,widely expressed,not involved in vivo in the phosphorylation of RPS6,mediating protein synthesis initiation and elongation induced by hormones or growth factors,maybe playing an essential regulatory role in protein synthesis during cell proliferation
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function:
Phosphorylates specifically ribosomal protein S6

Enzyme Numbers (IUBMB) for RPS6KB2 Gene

Gene Ontology (GO) - Molecular Function for RPS6KB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 9804755
GO:0004674 protein serine/threonine kinase activity TAS 9878560
GO:0004711 ribosomal protein S6 kinase activity IBA --
GO:0005524 ATP binding IEA --
GO:0042277 peptide binding IEA --
genes like me logo Genes that share ontologies with RPS6KB2: view
genes like me logo Genes that share phenotypes with RPS6KB2: view

Animal Models for RPS6KB2 Gene

MGI Knock Outs for RPS6KB2:

Animal Model Products

miRNA for RPS6KB2 Gene

miRTarBase miRNAs that target RPS6KB2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPS6KB2

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for RPS6KB2 Gene

Localization for RPS6KB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS6KB2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS6KB2 Gene COMPARTMENTS Subcellular localization image for RPS6KB2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for RPS6KB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with RPS6KB2: view

Pathways & Interactions for RPS6KB2 Gene

SuperPathways for RPS6KB2 Gene

Superpath Contained pathways
1 Interleukin receptor SHC signaling
2 PI3K/AKT Signaling in Cancer
3 Translation Insulin regulation of translation
4 Immune System
5 Downstream signaling events of B Cell Receptor (BCR)
genes like me logo Genes that share pathways with RPS6KB2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for RPS6KB2 Gene

Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for RPS6KB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS 9804755
GO:0006468 protein phosphorylation IBA --
GO:0007165 signal transduction TAS 9804755
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0008543 fibroblast growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with RPS6KB2: view

Drugs & Compounds for RPS6KB2 Gene

(7) Drugs for RPS6KB2 Gene - From: HMDB, ApexBio, and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
BI-D1870 Pharma P90 RSK inhibitor,ATP-competitive and cell-permeable 0
PF 4708671 Pharma P70 S6K1 isoform inhibitor,cell-permeable, S6K1 inhibitor 0
Rapamycin Pharma mTOR inhibitor 0
Wortmannin Pharma PI3K inhibitor,selective and irreversible 0

(3) Additional Compounds for RPS6KB2 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
Phosphatidylinositol
phosphoinositide
genes like me logo Genes that share compounds with RPS6KB2: view

Transcripts for RPS6KB2 Gene

Unigene Clusters for RPS6KB2 Gene

Ribosomal protein S6 kinase, 70kDa, polypeptide 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPS6KB2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS6KB2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^
SP1: - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - - - -
SP5: -
SP6: -
SP7: -
SP8: - -
SP9: - -
SP10: - - - - -
SP11:
SP12:
SP13: - -
SP14: - - - -
SP15: - - -
SP16:
SP17: -

ExUns: 16 ^ 17a · 17b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for RPS6KB2 Gene

GeneLoc Exon Structure for
RPS6KB2
ECgene alternative splicing isoforms for
RPS6KB2

Expression for RPS6KB2 Gene

mRNA expression in normal human tissues for RPS6KB2 Gene

Protein differential expression in normal tissues from HIPED for RPS6KB2 Gene

This gene is overexpressed in Adrenal (33.6) and Placenta (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS6KB2 Gene



SOURCE GeneReport for Unigene cluster for RPS6KB2 Gene Hs.534345

genes like me logo Genes that share expression patterns with RPS6KB2: view

Protein tissue co-expression partners for RPS6KB2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS6KB2 Gene

Orthologs for RPS6KB2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RPS6KB2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPS6KB2 35
  • 89.9 (n)
  • 94.81 (a)
RPS6KB2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPS6KB2 35
  • 90.35 (n)
  • 93.96 (a)
RPS6KB2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rps6kb2 35
  • 88.38 (n)
  • 92.95 (a)
Rps6kb2 16
Rps6kb2 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPS6KB2 35
  • 99.58 (n)
  • 99.17 (a)
RPS6KB2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rps6kb2 35
  • 88.31 (n)
  • 92.95 (a)
oppossum
(Monodelphis domestica)
Mammalia RPS6KB2 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPS6KB2 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPS6KB2 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPS6KB2 36
  • 76 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Pk17E 37
  • 36 (a)
S6k 37
  • 72 (a)
S6k 36
  • 59 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F28C10.3 37
  • 34 (a)
R04A9.5 37
  • 51 (a)
Y47D3A.16 37
  • 57 (a)
rsks-1 36
  • 46 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL389W 35
  • 54.98 (n)
  • 48.94 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B03586g 35
  • 50.31 (n)
  • 49.08 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SCH9 35
  • 52.72 (n)
  • 49.85 (a)
SCH9 36
  • 21 (a)
OneToMany
Species with no ortholog for RPS6KB2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for RPS6KB2 Gene

ENSEMBL:
Gene Tree for RPS6KB2 (if available)
TreeFam:
Gene Tree for RPS6KB2 (if available)

Paralogs for RPS6KB2 Gene

genes like me logo Genes that share paralogs with RPS6KB2: view

Variants for RPS6KB2 Gene

Sequence variations from dbSNP and Humsavar for RPS6KB2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs917570 -- 67,429,073(+) GGGAA(C/G/T)TGGGG intron-variant
rs1476792 -- 67,428,766(+) TTAAG(C/T)TCTGA intron-variant
rs1638588 -- 67,432,235(+) CTGTT(A/C/T)TGTTG intron-variant
rs1638589 -- 67,433,289(+) AGGGC(A/G)GGGCC intron-variant
rs1790753 -- 67,433,537(-) CCGGG(A/G)TGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPS6KB2 Gene

Variant ID Type Subtype PubMed ID
nsv897797 CNV Loss 21882294
nsv897801 CNV Loss 21882294
nsv897804 CNV Gain 21882294
dgv1193n71 CNV Loss 21882294
dgv1194n71 CNV Loss 21882294
dgv1195n71 CNV Loss 21882294
nsv897811 CNV Loss 21882294
nsv521723 CNV Loss 19592680
nsv524096 CNV Loss 19592680
nsv468604 CNV Loss 19166990

Variation tolerance for RPS6KB2 Gene

Residual Variation Intolerance Score: 43.73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.07; 93.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS6KB2 Gene

HapMap Linkage Disequilibrium report
RPS6KB2
Human Gene Mutation Database (HGMD)
RPS6KB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS6KB2 Gene

Disorders for RPS6KB2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for RPS6KB2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
recurrent hypersomnia
  • primary recurrent hypersomnia
kleine-levin syndrome
  • kleine levin syndrome
coffin-lowry syndrome
  • cls
mediastinitis
- elite association

Relevant External Links for RPS6KB2

Genetic Association Database (GAD)
RPS6KB2
Human Genome Epidemiology (HuGE) Navigator
RPS6KB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPS6KB2
genes like me logo Genes that share disorders with RPS6KB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS6KB2 Gene

Publications for RPS6KB2 Gene

  1. Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region. (PMID: 9804755) Gout I. … Yonezawa K. (J. Biol. Chem. 1998) 2 23 67
  2. Histone acetyltransferases interact with and acetylate p70 ribosomal S6 kinases in vitro and in vivo. (PMID: 19961954) Fenton T.R. … Gout I.T. (Int. J. Biochem. Cell Biol. 2010) 23 67
  3. Involvement of heterogeneous ribonucleoprotein F in the regulation of cell proliferation via the mammalian target of rapamycin/S6 kinase 2 pathway. (PMID: 20308064) Goh E.T. … Gout I. (J. Biol. Chem. 2010) 23 67
  4. The ubiquitination of ribosomal S6 kinases is independent from the mitogen-induced phosphorylation/activation of the kinase. (PMID: 18786649) Gwalter J. … Gout I. (Int. J. Biochem. Cell Biol. 2009) 23 67
  5. mTOR/S6 kinase pathway contributes to astrocyte survival during ischemia. (PMID: 19535330) Pastor M.D. … Calvo S. (J. Biol. Chem. 2009) 23 67

Products for RPS6KB2 Gene

Sources for RPS6KB2 Gene

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