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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPS6KB2 Gene

protein-coding   GIFtS: 71
GCID: GC11P067195

Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2

(Previous names: ribosomal protein S6 kinase, 70kD, polypeptide 2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 21 2     S6 Kinase-Related Kinase2 3
Serine/Threonine-Protein Kinase 14B2 3     EC 2.7.11.13 8
70 KDa Ribosomal Protein S6 Kinase 22 3     Ribosomal Protein S6 Kinase, 70kD, Polypeptide 21
P70S6K22 3     KLS2
S6K-beta2 3     P70-beta2
S6K-beta-22 3     P70-beta-12
S6K22 3     P70-beta-22
SRK2 3     S6K-beta22
STK14B2 3     p70(S6K)-beta2
P70 Ribosomal S6 Kinase Beta2 3     p70S6Kb2
P70 S6 Kinase Beta2 3     Ribosomal Protein S6 Kinase Beta-22
P70 S6K-Beta2 3     Serine/Threonine-Protein Kinase 14 Beta2
P70 S6KB2 3     p70-beta3
P70-S6K 22 3     EC 2.7.118

External Ids:    HGNC: 104371   Entrez Gene: 61992   Ensembl: ENSG000001756347   OMIM: 6089395   UniProtKB: Q9UBS03   

Export aliases for RPS6KB2 gene to outside databases

Previous GC identifers: GC11P069692 GC11P068892 GC11P067445 GC11P066971 GC11P066932 GC11P066952 GC11P063523


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RPS6KB2 Gene:
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase
contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic
translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and
cell proliferation. (provided by RefSeq, Jul 2008)

GeneCards Summary for RPS6KB2 Gene: 
RPS6KB2 (ribosomal protein S6 kinase, 70kDa, polypeptide 2) is a protein-coding gene. Diseases associated with RPS6KB2 include recurrent hypersomnia, and kleine-levin syndrome, and among its related super-pathways are Translation Insulin regulation of translation and Signaling by FGFR. GO annotations related to this gene include protein serine/threonine kinase activity and peptide binding. An important paralog of this gene is RPS6KA6.

UniProtKB/Swiss-Prot: KS6B2_HUMAN, Q9UBS0
Function: Phosphorylates specifically ribosomal protein S6

Gene Wiki entry for RPS6KB2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPS6KB2 gene promoter:
         p53   Bach2   GATA-2   CREB   HEN1   Max   deltaCREB   Sox9   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPS6KB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for RPS6KB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS6KB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.2   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13.1

RPS6KB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS6KB2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P067195:  view genomic region     (about GC identifiers)

Start:
67,195,931 bp from pter      End:
67,202,879 bp from pter
Size:
6,949 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KS6B2_HUMAN, Q9UBS0 (See protein sequence)
Recommended Name: Ribosomal protein S6 kinase beta-2  
Size: 482 amino acids; 53455 Da
Subcellular location: Cytoplasm. Nucleus
Sequence caution: Sequence=BAA34402.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B2RMZ9 O94809 Q9UEC1

Explore the universe of human proteins at neXtProt for RPS6KB2: NX_Q9UBS0

Explore proteomics data for RPS6KB2 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated and activated by MTOR. Phosphorylation by PKC within the NLS in response to mitogenic stimuli
    causes cytoplasmic retention
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UBS0

  • 4/20 DME Specific Peptides for RPS6KB2 (Q9UBS0) (see all 20)
     YMAPEIL  GHIKLTD  LGKGGYG  DFGLCKE 

    RPS6KB2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RPS6KB2 Protein Expression
    REFSEQ proteins: NP_003943.2  
    ENSEMBL proteins: 
     ENSP00000435716   ENSP00000450621   ENSP00000436811   ENSP00000410175   ENSP00000308413  
     ENSP00000432847   ENSP00000473485   ENSP00000442949  
    Reactome Protein details: Q9UBS0
    Human Recombinant Protein Products for RPS6KB2: 
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    Novus Biologicals RPS6KB2 Proteins
    Novus Biologicals RPS6KB2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IEA--
    GO:0005840ribosome ----

    RPS6KB2 for ontologies           About GeneDecksing



    RPS6KB2 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for RPS6KB2 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: ribosomal protein S6 kinase, 70kDa, polypeptide 2 
    p70 subfamily
    Other AGC kinases

    5/8 InterPro protein domains (see all 8):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR016238 Ribosomal_S6_kinase
     IPR000961 AGC-kinase_C
     IPR011009 Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9UBS0

    ProtoNet protein and cluster: Q9UBS0

    1 Blocks protein domain: IPB000961 Protein kinase C-terminal domain

    UniProtKB/Swiss-Prot: KS6B2_HUMAN, Q9UBS0
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 protein kinase domain


    RPS6KB2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KS6B2_HUMAN, Q9UBS0
    Function: Phosphorylates specifically ribosomal protein S6
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Genatlas biochemistry entry for RPS6KB2:
    ribosomal protein S6 kinase,70kDa,polypeptide 2,widely expressed,not involved in vivo in the phosphorylation of
    RPS6,mediating protein synthesis initiation and elongation induced by hormones or growth factors,maybe playing an
    essential regulatory role in protein synthesis during cell proliferation

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS9804755
    GO:0004674protein serine/threonine kinase activity TAS9878560
    GO:0004711ribosomal protein S6 kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IEA--
         
    RPS6KB2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for RPS6KB2:
     Decreased Wnt reporter activit  Decreased viability with RAF26  Increased telomerase activity 

         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rps6kb2):
     cardiovascular system  cellular  growth/size  homeostasis/metabolism  mortality/aging 
     muscle  normal  reproductive system 

    RPS6KB2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rps6kb2tm1Gtho for RPS6KB2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RPS6KB2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RPS6KB2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RPS6KB2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RPS6KB2 

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    Inhib. RNA
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: RPS6KB2 (NM_003952)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPS6KB2
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS6KB2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RPS6KB2 About   (see all 28)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Translation Insulin regulation of translation
    Translation Insulin regulation of translation0.59
    Development CNTF receptor signaling0.43
    Regulation of lipid metabolism Insulin signaling:generic cascades0.59
    mTOR signaling pathway0.34
    Transcription Receptor-mediated HIF regulation0.51
    Insulin signaling pathway0.31
    Translation Regulation activity of EIF4F0.44
    2Signaling by FGFR
    Downstream signaling of activated FGFR0.92
    Downstream signal transduction0.90
    Signaling by FGFR0.92
    Signaling by PDGF0.85
    Signaling by FGFR in disease0.91
    Signaling by EGFR0.84
    DAP12 signaling0.91
    Signaling by EGFR in Cancer0.83
    3PIP3 activates AKT signaling
    GAB1 signalosome0.93
    PI3K events in ERBB2 signaling0.88
    PI3K/AKT activation0.93
    PI3K events in ERBB4 signaling0.88
    PIP3 activates AKT signaling0.88
    Constitutive PI3K/AKT Signaling in Cancer0.88
    PI3K/AKT Signaling in Cancer0.88
    Signaling by SCF-KIT0.72
    4Immune System
    Immune System0.56
    Innate Immune System0.50
    Adaptive Immune System0.56
    5Signaling by the B Cell Receptor (BCR)
    Signaling by the B Cell Receptor (BCR)0.81
    Downstream Signaling Events Of B Cell Receptor (BCR)0.81

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/8 EMD Millipore Pathways for RPS6KB2 (see all 8)
        Translation Translation regulation by Alpha-1 adrenergic receptors
    Translation Insulin regulation of translation
    Translation Regulation activity of EIF4F
    Transcription Receptor-mediated HIF regulation
    Development CNTF receptor signaling

    1 R&D Systems Pathway for RPS6KB2
        Akt Signaling Pathway

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RPS6KB2
        FLT3 Signaling
    14-3-3 Induced Intracellular Signaling

    5/8 GeneGo (Thomson Reuters) Pathways for RPS6KB2 (see all 8)
        Apoptosis and survival BAD phosphorylation
    Translation Insulin regulation of translation
    Development Endothelin-1/EDNRA transactivation of EGFR
    Development CNTF receptor signaling
    Transcription Receptor-mediated HIF regulation

    5/6 BioSystems Pathways for RPS6KB2 (see all 6)
        Insulin Signaling
    AMPK signaling
    Cytoplasmic Ribosomal Proteins
    IL-3 Signaling Pathway
    IL-2 Signaling pathway


    5/32        Reactome Pathways for RPS6KB2 (see all 32)
        AKT phosphorylates targets in the nucleus
    Signaling by EGFR in Cancer
    Disease
    Signaling by ERBB2
    GAB1 signalosome


    5/9         Kegg Pathways  (Kegg details for RPS6KB2) (see all 9):
        ErbB signaling pathway
    HIF-1 signaling pathway
    mTOR signaling pathway
    PI3K-Akt signaling pathway
    TGF-beta signaling pathway


    RPS6KB2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RPS6KB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/799 Interacting proteins for RPS6KB2 (Q9UBS02, 3 ENSP000003084134) via UniProtKB, MINT, STRING, and/or I2D (see all 799)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EEF2KO004182, 3, ENSP000002630264MINT-15495 I2D: score=2 STRING: ENSP00000263026
    COASYQ130572, 3MINT-51121 I2D: score=3 
    MAPK8IP2Q133872, 3MINT-8262591 I2D: score=2 
    RPS6P627532, 3, ENSP000003697574MINT-2833483 I2D: score=2 STRING: ENSP00000369757
    CDC5LQ994592, ENSP000003605324MINT-7945693 MINT-7947479 STRING: ENSP00000360532
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation TAS9804755
    GO:0006468protein phosphorylation ----
    GO:0007165signal transduction TAS9804755
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0008543fibroblast growth factor receptor signaling pathway TAS--

    RPS6KB2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RPS6KB2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RPS6KB2 (KS6B2)

    2 HMDB Compounds for RPS6KB2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    6 Novoseek inferred chemical compound relationships for RPS6KB2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rapamycin 76.7 16 12713446 (2), 11108711 (1), 17678899 (1), 10490848 (1) (see all 10)
    wortmannin 64.7 6 17678899 (1), 10490848 (1), 10490847 (1), 12713446 (1)
    threonine 51 5 12713446 (3), 11108720 (1)
    phosphatidylinositol 40.8 1 12087098 (1)
    serine 38 5 12713446 (3), 11108720 (1)
    phosphoinositide 31.2 4 12713446 (2), 11108711 (1)

    Search CenterWatch for drugs/clinical trials and news about RPS6KB2 / KS6B2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RPS6KB2 gene (2 alternative transcripts): 
    NM_003952.2  NM_001007071.1  

    Unigene Cluster for RPS6KB2:

    Ribosomal protein S6 kinase, 70kDa, polypeptide 2
    Hs.534345  [show with all ESTs]
    Unigene Representative Sequence: BC000094
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000530623 ENST00000556575 ENST00000524934 ENST00000524814 ENST00000420069
    ENST00000312629(uc001old.3) ENST00000528964 ENST00000525088(uc021qmi.1)
    ENST00000525996 ENST00000525726 ENST00000526268 ENST00000531765 ENST00000539188


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    Additional mRNA sequence: 

    AB016869.1 AB019245.1 AF076931.1 AF099739.1 AK297527.1 BC000094.2 BC006106.1 BC136564.1 
    BX538119.1 

    13 DOTS entries:

    DT.112590  DT.100698514  DT.40237947  DT.100828823  DT.75198876  DT.100654415  DT.120719175  DT.95348289 
    DT.100828827  DT.120719178  DT.100828828  DT.120719177  DT.95327360 

    24/364 AceView cDNA sequences (see all 364):

    BU517144 BX381976 BX538119 CR622954 BM561338 BX093439 AB037815 AI807753 
    BM853302 BX377754 BG030830 CR602192 BI793022 BM710343 BC006106 BI825778 
    CR611291 BI793240 BQ431606 BQ072582 BE792760 BX472608 BU539321 BU931869 

    GeneLoc Exon Structure

    5/17 Alternative Splicing Database (ASD) splice patterns (SP) for RPS6KB2 (see all 17)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^
    SP1:                                                        -     -     -                                                           -                           
    SP2:                                                        -     -     -                                                     -     -                           
    SP3:                                                        -     -     -                             -                                                         
    SP4:                                                        -     -     -                 -     -     -                             -                           
    SP5:                                                        -                                                                                                   

    ExUns: 16 ^ 17a · 17b
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for RPS6KB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPS6KB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCTGAAAA
    RPS6KB2 Expression
    About this image


    See RPS6KB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPS6KB2

    SOURCE GeneReport for Unigene cluster: Hs.534345
        SABiosciences Expression via Pathway-Focused PCR Array including RPS6KB2: 
              mTOR Signaling in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RPS6KB2 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rps6kb21 , 5 ribosomal protein S6 kinase, polypeptide 21, 5 88.52(n)1
    93.15(a)1
      19 (3.86 cM)5
    589881  NM_021485.21  NP_067460.11 
     41567135 
    chicken
    (Gallus gallus)
    Aves RPS6KB26
    ribosomal protein S6 kinase, 70kDa, polypeptide 2
    90(a)
    1 ↔ 1
    AADN03022745.1(21-1265)
    lizard
    (Anolis carolinensis)
    Reptilia RPS6KB26
    ribosomal protein S6 kinase, 70kDa, polypeptide 2
    75(a)
    1 ↔ 1
    1(93292206-93310690)
    fruit fly
    (Drosophila melanogaster)
    Insecta S6k3 cell growth and/or maintenance protein
    serine/threonine more
    72(a)
    (best of 2)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea Y47D3A.163 ribosomal protein S6 kinase 57(a)
    (best of 3)
      III(11316958-11322832)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SCH96
    Protein kinase involved in transcriptional activat...
    20(a)
    1 → many
    VIII(509363-511837)


    ENSEMBL Gene Tree for RPS6KB2 (if available)
    TreeFam Gene Tree for RPS6KB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPS6KB2 gene
    RPS6KA62  AKT12  RPS6KB12  SGK32  C8orf44-SGK32  RPS6KA12  SGK22  RPS6KA52  
    AKT32  RPS6KA42  SGK12  RPS6KA32  AKT22  RPS6KA22  
    18/54 SIMAP similar genes for RPS6KB2 using alignment to 7 protein entries:     KS6B2_HUMAN (see all proteins) (see all similar genes):
    RPS6KB1    RPS6KA2    KIN27    RPS6KA5    RPS6KA3    RPS6KA6
    BRSK2    PRKACA    RPS6KA4    PRKCI    SGK3    SGK2
    PRKACB    PRKG1    RPS6KA1    DKFZp781N0293    PRKACG    SGKL

    RPS6KB2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/268 SNPs in RPS6KB2 are shown (see all 268)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0406464
    An ovarian mucinous carcinoma sample4--see VAR_0406462 T M mis40--------
    rs1919079151,2
    --67193982(+) TCAAGC/TGATTT 1 -- us2k10--------
    rs1816242751,2
    --67194040(+) ACTCCC/TGGCTA 1 -- us2k10--------
    rs1167577561,2
    F--67194329(+) CTCCCC/TTCTAA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1858453861,2
    --67194393(+) CATTCC/TAGTTA 1 -- us2k10--------
    rs122251351,2
    H--67194505(+) cctgtC/Ttgaaa 1 -- us2k14Minor allele frequency- T:0.00NS EA 420
    rs124205261,2
    H--67194585(+) tttaaA/Gatgga 1 -- us2k10--------
    rs112277931,2
    C,A--67194593(+) GGAGTT/CTCGCT 1 -- us2k12Minor allele frequency- C:0.00NA 4
    rs1902542291,2
    C--67194595(+) AGTCTC/TGCTCT 1 -- us2k10--------
    rs1823844581,2
    C--67194720(+) CACCAA/CCATGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RPS6KB2 (67195931 - 67202879 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for RPS6KB2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv468604CNV Loss19166990
    dgv1195n71CNV Loss21882294
    nsv897797CNV Loss21882294
    nsv521723CNV Loss19592680
    nsv897811CNV Loss21882294
    nsv524096CNV Loss19592680
    dgv1194n71CNV Loss21882294
    dgv1193n71CNV Loss21882294
    nsv897801CNV Loss21882294
    nsv897804CNV Gain21882294


    Human Gene Mutation Database (HGMD): RPS6KB2
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608939    OMIM disorders: --

    17 diseases for RPS6KB2:    About MalaCards
    recurrent hypersomnia    kleine-levin syndrome    landau-kleffner syndrome    coffin-lowry syndrome
    hypersomnia    sensenbrenner syndrome    craniosynostosis    endometrial adenocarcinoma
    gout    lung cancer    acute myeloid leukemia    adenocarcinoma
    ischemia    myeloid leukemia    alzheimer's disease    leukemia
    breast cancer

    2 diseases from the University of Copenhagen DISEASES database for RPS6KB2:
    Kleine-Levin syndrome     Landau-Kleffner syndrome

    RPS6KB2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    4 Novoseek inferred disease relationships for RPS6KB2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    small cell lung cancer 30.8 1 16810323 (1)
    adenocarcinoma 15.9 3 15627062 (2), 15112576 (1)
    tumors 0 10 15627062 (4), 15112576 (3), 15995633 (1)
    cancer 0 6 15995633 (2), 15112576 (1), 15627062 (1)

    Genetic Association Database (GAD): RPS6KB2
    Human Genome Epidemiology (HuGE) Navigator: RPS6KB2 (4 documents)

    Export disorders for RPS6KB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPS6KB2 gene, integrated from 9 sources (see all 59):
    (articles sorted by number of sources associating them with RPS6KB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region. (PubMed id 9804755)1, 2, 3, 9 Gout I.... Yonezawa K. (1998)
    2. Cloning and characterization of p70 S6Kbeta defines a novel family of p70 S6 kinases. (PubMed id 9878560)1, 2, 3 Saitoh M.... Ichijo H. (1998)
    3. Regulation of ribosomal S6 kinase 2 by mammalian target of rapamycin. (PubMed id 12087098)1, 2, 9 Park I.H....Chen J. (2002)
    4. Characterization of S6K2, a novel kinase homologous to S6K1. (PubMed id 10490847)1, 2, 9 Lee-Fruman K.K.... Blenis J. (1999)
    5. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage he ad and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (2010)
    6. Genetic variation in RPS6KA1, RPS6KA2, RPS6KB1, RPS6K B2, and PDK1 and risk of colon or rectal cancer. (PubMed id 21035469)1, 4 Slattery M.L....Wolff R.K. (2010)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Protein kinase C phosphorylates ribosomal protein S6 kinase betaII and regulates its subcellular localization. (PubMed id 12529391)1, 2 Valovka T....Gout I.T. (2003)
    10. Cloning and characterization of a nuclear S6 kinase, S6 kinase-related kinase (SRK); a novel nuclear target of Akt. (PubMed id 10490848)1, 9 Koh H....Chung J. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6199 HGNC: 10437 AceView: RPS6KB2andKIAA1394 Ensembl:ENSG00000175634 euGenes: HUgn6199
    ECgene: RPS6KB2 Kegg: 6199 H-InvDB: RPS6KB2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPS6KB2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RPS6KB2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RPS6KB2 gene:
    Search GeneIP for patents involving RPS6KB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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