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RPS6KB1 Gene

protein-coding   GIFtS: 74
GCID: GC17P057970

Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1

(Previous names: ribosomal protein S6 kinase, 70kD, polypeptide 1)
(Previous symbol: STK14A)
  See RPS6KB1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 11 2     p70(S6K)-alpha2
STK14A1 2 3     p70-S6K2
S6K12 3 5     p70-alpha2
Ribosomal Protein S6 Kinase I2 3     Ribosomal Protein S6 Kinase Beta-12
Serine/Threonine-Protein Kinase 14A2 3     Serine/Threonine Kinase 14 Alpha2
S6K-beta-12 3     70 KDa Ribosomal Protein S6 Kinase 13
P70 S6KA2 3     P70S6K13
EC 2.7.11.13 8     P70 Ribosomal S6 Kinase Alpha3
Ribosomal Protein S6 Kinase, 70kD, Polypeptide 11     P70 S6 Kinase Alpha3
PS6K2     P70 S6K-Alpha3
S6K2     P70-S6K 13
P70 S6 Kinase, Alpha2     EC 2.7.118

External Ids:    HGNC: 104361   Entrez Gene: 61982   Ensembl: ENSG000001084437   OMIM: 6089385   UniProtKB: P234433   

Export aliases for RPS6KB1 gene to outside databases

Previous GC identifers: GC17M060023 GC17P060420 GC17P058312 GC17P058444 GC17P055325 GC17P053343


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RPS6KB1 Gene:
This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein
responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell
proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript
variants have been observed. The use of alternative translation start sites results in isoforms with longer or
shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on
chromosome 17. (provided by RefSeq, Jan 2013)

GeneCards Summary for RPS6KB1 Gene:
RPS6KB1 (ribosomal protein S6 kinase, 70kDa, polypeptide 1) is a protein-coding gene. Diseases associated with RPS6KB1 include tuberous sclerosis, and tuberous sclerosis complex. GO annotations related to this gene include ribosomal protein S6 kinase activity and protein kinase activity. An important paralog of this gene is AKT1.

UniProtKB/Swiss-Prot: KS6B1_HUMAN, P23443
Function: Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and
nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis
through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the
pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3
translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin
complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation. The active form then
phosphorylates and activates several substrates in the preinitiation complex, including the EIF2B complex and the
cap-binding complex component EIF4B. Also controls translation initiation by phosphorylating a negative regulator
of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis. Promotes initiation of the pioneer
round of protein synthesis by phosphorylating POLDIP3/SKAR. In response to IGF1, activates translation elongation
by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2. Also plays a
role in feedback regulation of mTORC2 by mTORC1 by phosphorylating RICTOR, resulting in the inhibition of mTORC2
and AKT1 signaling. Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its
pro-apoptotic function. Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex. The
free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative
feedback mechanism for the RPS6KB1 anti-apoptotic function. Mediates TNF-alpha-induced insulin resistance by
phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1. In cells lacking
functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B. May be involved in cytoskeletal
rearrangement through binding to neurabin. Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD,
downstream of MTOR

summary for RPS6KB1 Gene:
p70 ribosomal S6 kinase (S6K) exists as two isoforms - S6K1 and S6K2 - which are activated by mitogenic
stimuli such as growth factors, insulin and cytokines. In turn, p70 S6K phosphorylates the ribosomal protein
S6. The S6K1 isoform also phosphorylates other proteins involved in the cell's translational machinery,
including elF4B (initiation factor); eEF2K (elongation factor 2 kinase); and SKAR (RNA binding protein). As
such, it is thought that S6K1 may be directly involved in cell growth and when considered alongside its
position downstream of the PI3K and mTOR pathways, this activity makes S6K1 a potential target for cancer
therapy.

Gene Wiki entry for RPS6KB1 (P70-S6 Kinase 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPS6KB1 gene promoter:
         NF-1   NF-1/L   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   YY1   CREB   E2F   E2F-1   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPS6KB1 promoter sequence
   Search Chromatin IP Primers for RPS6KB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPS6KB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.1   Ensembl cytogenetic band:  17q23.1   HGNC cytogenetic band: 17q23.1

RPS6KB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS6KB1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P057970:  view genomic region     (about GC identifiers)

Start:
57,970,443 bp from pter      End:
58,027,925 bp from pter
Size:
57,483 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KS6B1_HUMAN, P23443 (See protein sequence)
Recommended Name: Ribosomal protein S6 kinase beta-1  
Size: 525 amino acids; 59140 Da
Subunit: Interacts with PPP1R9A/neurabin-1 (By similarity). Interacts with RPTOR. Interacts with IRS1. Interacts
with EIF3B and EIF3C. Interacts with POLDIP3 and TRAF4
Selected PDB 3D structures from and Proteopedia for RPS6KB1 (see all 10):
3A60 (3D)        3A61 (3D)        3A62 (3D)        4L3J (3D)        4L3L (3D)        4L42 (3D)    
Alternative initiation: 2 isoforms:  P23443-1   P23443-2   

Explore the universe of human proteins at neXtProt for RPS6KB1: NX_P23443

Explore proteomics data for RPS6KB1 at MOPED

Post-translational modifications: 

  • Phosphorylation at Thr-412 is regulated by mTORC1. The phosphorylation at this site is maintained by an
    agonist-dependent autophosphorylation mechanism (By similarity). Activated by phosphorylation at Thr-252 by
    PDPK1. Dephosphorylation by PPP1CC at Thr-412 in mitochondrion1
  • Ubiquitination2 at Lys104
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for RPS6KB1 (P23443) (see all 19)
     YMAPEIL  LGKGGYG  DFGLCKE  SEEDVSQ 


    See RPS6KB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001258971.1  NP_001258972.1  NP_001258973.1  NP_001258989.1  NP_003152.1  

    ENSEMBL proteins: 
     ENSP00000468058   ENSP00000441993   ENSP00000466562   ENSP00000384335   ENSP00000225577  
     ENSP00000464805   ENSP00000376744  
    Reactome Protein details: P23443

    RPS6KB1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant RPS6KB1 Protein
    R&D Systems Recombinant & Natural Proteins for RPS6KB1 (p70 S6 Kinase)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RPS6KB1
    OriGene Protein Over-expression Lysate for RPS6KB1
    OriGene MassSpec for RPS6KB1
    OriGene Custom Protein Services for RPS6KB1
    GenScript Custom Purified and Recombinant Proteins Services for RPS6KB1
    Novus Biologicals RPS6KB1 Proteins
    Novus Biologicals RPS6KB1 Lysates
    Sino Biological Recombinant Protein for RPS6KB1
    Sino Biological Cell Lysate for RPS6KB1
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for RPS6KB1 

    RPS6KB1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of RPS6KB1
    R&D Systems Antibodies for RPS6KB1 (p70 S6 Kinase)
    Cell Signaling Technology (CST) Antibodies for RPS6KB1  (p70S6K)
    OriGene Antibodies for RPS6KB1
    OriGene Custom Antibody Services for RPS6KB1
    Novus Biologicals RPS6KB1 Antibodies
    Abcam antibodies for RPS6KB1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for RPS6KB1
    LSBio Antibodies in human, mouse, rat for RPS6KB1

    RPS6KB1 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of RPS6KB1
    OriGene Custom Assay Services for RPS6KB1
    R&D Systems ELISAs for RPS6KB1 (p70 S6 Kinase)         (see all)
    GenScript RPS6KB1-Activity-based Kinase Assay for Compound Screening
    Cell Signaling Technology (CST) Sandwich ELISA Kits for RPS6KB1 (p70S6K)
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    eBioscience ELISAs for RPS6KB1: (see all 3
                        p70 S6K (Total/Phospho) InstantOne ELISA 96 tests


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: ribosomal protein S6 kinase, 70kDa, polypeptide 1
    p70 subfamily
    Other AGC kinases

    Selected InterPro protein domains (see all 8):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR016238 Ribosomal_S6_kinase
     IPR000961 AGC-kinase_C
     IPR011009 Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry P23443

    ProtoNet protein and cluster: P23443

    1 Blocks protein domain: IPB000961 Protein kinase C-terminal domain

    UniProtKB/Swiss-Prot: KS6B1_HUMAN, P23443
    Domain: The autoinhibitory domain is believed to block phosphorylation within the AGC-kinase C-terminal domain and
    the activation loop
    Domain: The TOS (TOR signaling) motif is essential for activation by mTORC1 (By similarity)
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with RPS6KB1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KS6B1_HUMAN, P23443
    Function: Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and
    nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis
    through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the
    pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3
    translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin
    complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation. The active form then
    phosphorylates and activates several substrates in the preinitiation complex, including the EIF2B complex and the
    cap-binding complex component EIF4B. Also controls translation initiation by phosphorylating a negative regulator
    of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis. Promotes initiation of the pioneer
    round of protein synthesis by phosphorylating POLDIP3/SKAR. In response to IGF1, activates translation elongation
    by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2. Also plays a
    role in feedback regulation of mTORC2 by mTORC1 by phosphorylating RICTOR, resulting in the inhibition of mTORC2
    and AKT1 signaling. Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its
    pro-apoptotic function. Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex. The
    free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative
    feedback mechanism for the RPS6KB1 anti-apoptotic function. Mediates TNF-alpha-induced insulin resistance by
    phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1. In cells lacking
    functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B. May be involved in cytoskeletal
    rearrangement through binding to neurabin. Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD,
    downstream of MTOR
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activation requires multiple phosphorylation events on serine/threonine residues. Activation
    appears to be first mediated by phosphorylation of multiple sites in the autoinhibitory domain, which facilitates
    phosphorylation at Thr-412, disrupting the autoinhibitory mechanism and allowing phosphorylation of Thr-252 by
    PDPK1. The active conformation of the kinase is believed to be stabilized by a mechanism involving three
    conserved phosphorylation sites located in the kinase domain activation loop (Thr-252) and in the AGC-kinase
    C-terminal domain (Ser-394 in the middle of the tail/linker region and Thr-412 within a hydrophobic motif at its
    end). Activated by mTORC1; isoform Alpha I and isoform Alpha II are sensitive to rapamycin, which inhibits
    activating phosphorylation at Thr-412. Activated by PDPK1

         Genatlas biochemistry entry for RPS6KB1:
    ribosomal protein S6 kinase,70kDa,polypeptide 1,widely expressed,not involved in vivo in the phosphorylation of
    RPS6,mediating protein synthesis initiation and elongation induced by hormones or growth factors,maybe playing an
    essential regulatory role in protein synthesis during cell proliferation

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA17936702
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004711ribosomal protein S6 kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI12150926
         
    Find genes that share ontologies with RPS6KB1           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for RPS6KB1:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Decreased viability with pacli  Increased cell death HMECs cel 
     Upregulation of Wnt/beta-caten 

         12 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rps6kb1):
     cardiovascular system  cellular  embryogenesis  endocrine/exocrine gland  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  muscle 
     reproductive system  tumorigenesis 

    Find genes that share phenotypes with RPS6KB1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for RPS6KB1: Rps6kb1tm1Gtho Rps6kb1tm1Nte

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RPS6KB1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RPS6KB1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RPS6KB1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RPS6KB1

    miRNA
    Products:
        
    miRTarBase miRNAs that target RPS6KB1:
    hsa-mir-877-3p (MIRT037006), hsa-mir-192-5p (MIRT026123), hsa-mir-877-5p (MIRT037328), hsa-mir-98-5p (MIRT027419), hsa-mir-215-5p (MIRT024333), hsa-mir-16-5p (MIRT031441), hsa-mir-103a-3p (MIRT027002)

    Block miRNA regulation of human, mouse, rat RPS6KB1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RPS6KB1 (see all 55):
    hsa-miR-579 hsa-miR-100* hsa-miR-429 hsa-miR-605 hsa-miR-128 hsa-miR-218 hsa-miR-507 hsa-miR-3161
    SwitchGear 3'UTR luciferase reporter plasmidRPS6KB1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RPS6KB1
    Predesigned siRNA for gene silencing in human, mouse, rat RPS6KB1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RPS6KB1

    Clone
    Products:
         
    OriGene clones in human, mouse for RPS6KB1 (see all 11)
    OriGene ORF clones in mouse, rat for RPS6KB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RPS6KB1 (NM_003161)
    Sino Biological Human cDNA Clone for RPS6KB1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPS6KB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS6KB1
    Addgene plasmids for RPS6KB1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RPS6KB1
    Browse ESI BIO Cell Lines and PureStem Progenitors for RPS6KB1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS6KB1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KS6B1_HUMAN, P23443: Cell junction, synapse, synaptosome (By similarity). Mitochondrion outer membrane.
    Mitochondrion. Note=Colocalizes with URI1 at mitochondrion
    KS6B1_HUMAN, P23443: Isoform Alpha I: Nucleus. Cytoplasm
    KS6B1_HUMAN, P23443: Isoform Alpha II: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus5
    cytosol4
    cytoskeleton2
    extracellular2
    plasma membrane2
    vacuole2
    lysosome1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA19085255
    GO:0005739mitochondrion IDA17936702
    GO:0005741mitochondrial outer membrane IEA--

    Find genes that share ontologies with RPS6KB1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RPS6KB1 About   (see all 67)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Development IGF 1 receptor signaling
    Development IGF RI signaling0.49
    Development IGF 1 receptor signaling0.48
    Signal transduction AKT signaling0.49
    Immune response IL 4 signaling pathway0.39
    2Insulin receptor signalling cascade
    Insulin receptor signalling cascade0.94
    Signaling by Insulin receptor0.80
    IRS-related events0.94
    PKB-mediated events0.41
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.92
    mTOR signalling0.39
    IRS-mediated signalling0.92
    TOR signaling0.32
    3IL-9 Signaling Pathways
    IL-9 Signaling Pathways0.90
    IL-15 Signaling Pathways0.88
    IL-7 Signaling Pathways0.90
    IL-4 Signaling Pathways0.84
    IL-21 Signaling Pathways0.90
    Development Thrombopoietin regulated cell processes0.38
    Common Cytokine Receptor Gamma-Chain Family Signaling Pathways0.90
    Adipocytokines and Insulin Signaling0.34
    4Translation Insulin regulation of translation
    Translation Insulin regulation of translation0.59
    Development CNTF receptor signaling0.43
    Regulation of lipid metabolism Insulin signaling generic cascades0.59
    Development Growth hormone signaling via PI3K AKT and MAPK cascades0.34
    Transcription Receptor mediated HIF regulation0.51
    mTOR signaling pathway0.34
    Translation Regulation activity of EIF4F0.44
    Insulin signaling pathway0.32
    5ErbB signaling pathway
    ErbB signaling pathway0.52
    ErbB signaling pathway0.52


    Find genes that share SuperPaths with RPS6KB1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for RPS6KB1 (see all 10)
        IL-21 Signaling Pathways
    IL-2 Signaling Pathways
    IL-4 Signaling Pathways
    Adipocytokines & Insulin Signaling
    Akt Signaling Pathway

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RPS6KB1 (see all 25)
        FLT3 Signaling
    UVB-Induced MAPK Signaling
    IL-4 Pathway
    Interferon Pathway
    Glioblastoma Multiforme

    1 Cell Signaling Technology (CST) Pathway for RPS6KB1
        Translational Control

    Selected GeneGo (Thomson Reuters) Pathways for RPS6KB1 (see all 18)
        Development Endothelin-1/EDNRA transactivation of EGFR
    Development CNTF receptor signaling
    Signal transduction AKT signaling
    Translation Insulin regulation of translation
    Transcription Receptor-mediated HIF regulation

    Selected BioSystems Pathways for RPS6KB1 (see all 29)
        TOR signaling
    Insulin Signaling
    G13 Signaling Pathway
    ErbB signaling pathway
    AMPK signaling

    1 Sino Biological Pathway for RPS6KB1
        TGF-beta Signaling Pathway

    2 Reactome Pathways for RPS6KB1
        S6K1-mediated signalling
    S6K1 signalling


    Selected Kegg Pathways  (Kegg details for RPS6KB1) (see all 9):
        ErbB signaling pathway
    HIF-1 signaling pathway
    mTOR signaling pathway
    PI3K-Akt signaling pathway
    TGF-beta signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RPS6KB1 (see all 8): 
              mTOR Signaling in human mouse rat
              Insulin Resistance in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              Autophagy in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RPS6KB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPS6KB1 (P234431, 2, 3 ENSP000002255774) via UniProtKB, MINT, STRING, and/or I2D (see all 165)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COASYQ130572, 3MINT-51122 MINT-51123 MINT-51062 MINT-51063 I2D: score=4 
    MAPTP106362, 3, ENSP000003408204MINT-74874 MINT-74872 I2D: score=1 STRING: ENSP00000340820
    PDPK1O155302, 3, ENSP000003442204MINT-14377 I2D: score=3 STRING: ENSP00000344220
    CLEC3BP054522, 3, ENSP000002961304MINT-8269989 I2D: score=2 STRING: ENSP00000296130
    DPPA4Q7L1902, 3, ENSP000003353064MINT-8270000 I2D: score=2 STRING: ENSP00000335306
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 46):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle IMP14673156
    GO:0003009skeletal muscle contraction IEA--
    GO:0006468protein phosphorylation IDA19085255
    GO:0006915apoptotic process IEA--
    GO:0007165signal transduction TAS1922062

    Find genes that share ontologies with RPS6KB1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for RPS6KB1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BRD 7389p90 ribosomal S6 kinase inhibitor[376382-11-5]
    PF 4708671S6K1 inhibitor[1255517-76-0]
    SL 0101-1Selective p90 ribosomal S6 kinase (RSK) inhibitor[77307-50-7]

    2 HMDB Compounds for RPS6KB1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Selected Novoseek inferred chemical compound relationships for RPS6KB1 gene (see all 75)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rapamycin 95.5 518 9271419 (6), 17660033 (5), 14871980 (5), 8389370 (5) (see all 99)
    wortmannin 82.5 75 7545671 (3), 9468542 (2), 11446769 (2), 12296652 (2) (see all 50)
    ly294002 82.4 39 12242656 (3), 9367837 (2), 13679036 (1), 16139919 (1) (see all 31)
    phosphatidylinositol 81.9 96 18948408 (4), 12183455 (3), 7961833 (3), 11279232 (3) (see all 56)
    everolimus 74 21 14729632 (4), 20204306 (2), 18332467 (2), 19471857 (1) (see all 8)
    phosphoinositide 70.3 35 8621477 (2), 15816524 (2), 7826337 (2), 11027274 (2) (see all 20)
    threonine 66.3 31 18461003 (3), 12555062 (2), 12713446 (2), 9751223 (2) (see all 23)
    serine 59.5 50 18948408 (3), 20203102 (3), 16914728 (3), 18952604 (2) (see all 29)
    pd 98,059 58.6 12 11279232 (2), 12242656 (1), 11368346 (1), 19474060 (1) (see all 11)
    phosphatidylinositol-3,4,5-trisphosphate 54 1 9768361 (1)

    1 PharmGKB related drug/compound annotation for RPS6KB1 gene    About this table
    Drug/compound PharmGKB Annotation
    everolimus



    Find genes that share compounds with RPS6KB1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RPS6KB1 gene (5 alternative transcripts): 
    NM_001272042.1  NM_001272043.1  NM_001272044.1  NM_001272060.1  NM_003161.3  

    Unigene Cluster for RPS6KB1:

    Ribosomal protein S6 kinase, 70kDa, polypeptide 1
    Hs.463642  [show with all ESTs]
    Unigene Representative Sequence: NM_001272044
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000472940 ENST00000477179 ENST00000443572 ENST00000489824 ENST00000406116(uc010ddj.2)
    ENST00000225577(uc002ixy.3 uc010wom.2 uc010won.2 uc010woo.2)
    ENST00000592726 ENST00000587622 ENST00000590928 ENST00000475155 ENST00000587061
    ENST00000393021
    miRNA
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    hsa-miR-579 hsa-miR-100* hsa-miR-429 hsa-miR-605 hsa-miR-128 hsa-miR-218 hsa-miR-507 hsa-miR-3161
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      QuantiFast Probe-based Assays in human, mouse, rat RPS6KB1

    Additional mRNA sequence: 

    AK026730.1 AK091503.1 AK293247.1 AK297147.1 AK300202.1 AK312875.1 BC030763.2 BC053365.1 
    M60724.1 

    11 DOTS entries:

    DT.316003  DT.95270971  DT.100785618  DT.91858174  DT.121012844  DT.121012842  DT.65285220  DT.91746169 
    DT.92029419  DT.100683971  DT.91864442 

    Selected AceView cDNA sequences (see all 230):

    BE049560 AW304374 BF439519 BC053365 AL602438 CA419798 AA362032 BU677653 
    AI754381 AA805666 AI620614 AA768404 AI142096 AW949378 BQ777439 AI262530 
    AI278237 AU077265 AA828362 BE877872 BP359158 CR604237 BU160729 AU103944 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RPS6KB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAAATGTTG
    RPS6KB1 Expression
    About this image


    RPS6KB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Primary Oocyte Primary Follicle
             Oviduct
     
     Gonad (Reproductive System)    fully expand to see all 3 entries
             Testis Somatic Cells Primitive Gonad
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    RPS6KB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPS6KB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.463642

    UniProtKB/Swiss-Prot: KS6B1_HUMAN, P23443
    Tissue specificity: Widely expressed

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RPS6KB1 (see all 8): 
              mTOR Signaling in human mouse rat
              Insulin Resistance in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              Autophagy in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS6KB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPS6KB1 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rps6kb11 , 5 ribosomal protein S6 kinase, polypeptide 11, 5 94.6(n)1
    99.43(a)1
      11 (51.82 cM)5
    725081  NM_001114334.11  NP_001107806.11 
     864988715 
    chicken
    (Gallus gallus)
    Aves RPS6KB11 ribosomal protein S6 kinase, 70kDa, polypeptide 1 88.58(n)
    97.21(a)
      417637  NM_001030721.1  NP_001025892.1 
    lizard
    (Anolis carolinensis)
    Reptilia RPS6KB16
    ribosomal protein S6 kinase, 70kDa, polypeptide 1
    95(a)
    1 ↔ 1
    GL343470.1(194051-214697)
    African clawed frog
    (Xenopus laevis)
    Amphibia rps6kb1-A2 ribosomal protein S6 kinase, 70kDa, polypeptide 1 79.25(n)    AJ131521.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.245282 Danio rerio cDNA clone MGC55713 IMAGE3815976, complete cds less 80.49(n)    BC046888.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta S6k1 , 3 cell growth and/or maintenance protein
    serine/threonine kinase less3
    RPS6-p70-protein kinase1
    72(a)
    (best of 2)3
    65.85(n)1
    73.22(a)1
      386541  NM_001274521.11  NP_001261450.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y47D3A.163
    rsks-11
    ribosomal protein S6 kinase3
    rsks-11
    60(a)
    (best of 3)3
    63.15(n)1
    68.38(a)1
      III(11316958-11322832)3
    1765541  NM_067046.31  NP_499447.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YPK3(YBR028C)4 An AGC kinase phosphorylated by cAMP-dependent protein kinase (PKA) in a TORC1-dependent manner less   --   2(296002-294425) 852316  NP_009584.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PK11 PK1 52.08(n)
    49.37(a)
      820020  NM_111707.3  NP_187485.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g03340001 Os03g0334000 54.9(n)
    48.75(a)
      4332748  NM_001056562.1  NP_001050027.1 


    ENSEMBL Gene Tree for RPS6KB1 (if available)
    TreeFam Gene Tree for RPS6KB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RPS6KB1 gene
    AKT12  GRK72  GRK12  SGK32  GRK42  GRK62  C8orf44-SGK32  SGK22  
    ADRBK22  AKT32  SGK12  RPS6KB22  GRK52  ADRBK12  AKT22  
    Selected SIMAP similar genes for RPS6KB1 using alignment to 8 protein entries:     KS6B1_HUMAN (see all proteins) (see all similar genes):
    RPS6KB2    RPS6KA2    RPS6KA3    AKT3    PRKCE    RPS6KA1
    RPS6KA4    SGK2    PKN2    PRKCI    MARK4    PRKCQ
    PRKCH    PRKACA    RPS6KA6    PRKCB    PRKCZ    RPS6KA5

    Find genes that share paralogs with RPS6KB1           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for RPS6KB1 (see all 6)
    PGOHUM00000237046 PGOHUM00000237050 PGOHUM00000237051 PGOHUM00000237059 PGOHUM00000237134


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RPS6KB1 (see all 1070)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356284
    A colorectal cancer sample4--see VAR_0356282 G E mis40--------
    rs1127924011,2
    C--57972697(+) TTTTTC/G/TTTTGA 5 -- int11CSA 2
    rs116557551,2
    C,F,A,H--57972849(+) ggctaC/Attttt 5 -- int15Minor allele frequency- A:0.12NA EA 250
    rs1135765831,2
    C--57980678(+) AAAAG-/AAAAAA 5 -- int11Minor allele frequency- A:0.50CSA 2
    rs603563501,2
    C--57981782(+) CGGAG-/TCTGCC 5 -- int10--------
    rs602965681,2
    C--57981786(+) AGCTG-/CCTCTA 5 -- int10--------
    rs359089051,2
    C--57984367(+) TTTTT-/TGAGAC 5 -- int10--------
    rs340662621,2
    C--57984901(+) TTTTTT/-GAGAC 5 -- int11Minor allele frequency- -:0.50CSA 2
    rs126034801,2
    C,F,A,H--57986274(+) gcgccC/TggccA 5 -- int11Minor allele frequency- T:0.50NA 4
    rs1124682591,2
    F--57986354(+) GCGATG/CTCGGC 5 -- int12Minor allele frequency- C:0.50CSA 4

    HapMap Linkage Disequilibrium report for RPS6KB1 (57970443 - 58027925 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for RPS6KB1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv471544CNV Duplication19718026
    nsv428348CNV Gain18775914
    nsv471702CNV Gain15918152
    esv24411CNV Gain19812545
    nsv833502CNV Gain17160897
    nsv9576CNV Gain+Loss18304495
    dgv996e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): RPS6KB1
    1 Site Specific Mutation Identification with PCR Assay for RPS6KB1:
    Cosmic IdAA Change
    32843p.G289E
    1 Copy Number PCR Panel containing RPS6KB1:
    Kinases & Phosphatases
    SeqTarget long-range PCR primers for resequencing RPS6KB1
    DNA2.0 Custom Variant and Variant Library Synthesis for RPS6KB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608938    OMIM disorders: --

    2 diseases for RPS6KB1:    
    About MalaCards
    tuberous sclerosis    tuberous sclerosis complex

    2 diseases from the University of Copenhagen DISEASES database for RPS6KB1:
    Cancer     Tuberous sclerosis

    Find genes that share disorders with RPS6KB1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for RPS6KB1 gene (see all 44)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tuberous sclerosis 75.5 9 16914728 (2), 15249583 (1), 12384518 (1), 18094073 (1) (see all 6)
    tumors 44.3 52 15112576 (3), 15627062 (3), 12733712 (2), 16489002 (2) (see all 30)
    cancer 42.9 28 12433206 (4), 17624310 (2), 17452018 (1), 12733712 (1) (see all 16)
    glioblastoma 37.2 1 20423992 (1)
    rhabdomyosarcoma 36.4 5 12000755 (1), 15735038 (1), 17585318 (1), 8909805 (1)
    retinoblastoma 33.9 1 11426655 (1)
    insulin resistance 33.2 24 16753575 (3), 18948408 (3), 18252807 (2), 18952604 (1) (see all 11)
    hamartoma 28.5 1 16914728 (1)
    hypertrophy 26.6 14 9242178 (4), 15963500 (2), 18160324 (2), 16717578 (1) (see all 7)
    ataxia telangiectasia 24.2 1 10971657 (1)

    Genetic Association Database (GAD): RPS6KB1
    Human Genome Epidemiology (HuGE) Navigator: RPS6KB1 (11 documents)

    Export disorders for RPS6KB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RPS6KB1 gene, integrated from 10 sources (see all 802):
    (articles sorted by number of sources associating them with RPS6KB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini. (PubMed id 1922062)1, 2, 3 Grove J.... Woodgett J.R. (Mol. Cell. Biol. 1991)
    2. S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2. (PubMed id 18952604)1, 2, 9 Zhang J.... Ye J. (J. Biol. Chem. 2008)
    3. mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. (PubMed id 16286006)1, 2, 9 Holz M.K.... Blenis J. (Cell 2005)
    4. mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E. (PubMed id 14673156)1, 2, 9 Fingar D.C....Blenis J. (Mol. Cell. Biol. 2004)
    5. SKAR is a specific target of S6 kinase 1 in cell growth control. (PubMed id 15341740)1, 2, 9 Richardson C.J.... Blenis J. (Curr. Biol. 2004)
    6. Phosphorylation and activation of p70s6k by PDK1. (PubMed id 9445476)1, 2, 9 Pullen N.... Thomas G. (Science 1998)
    7. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. (PubMed id 12150926)1, 2, 9 Hara K.... Yonezawa K. (Cell 2002)
    8. Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation. (PubMed id 19864428)1, 2, 9 Sunami T.... Sharma S. (J. Biol. Chem. 2010)
    9. Regulation and localization of ribosomal protein S6 kinase 1 isoforms. (PubMed id 19085255)1, 2, 9 Kim D.... Meric-Bernstam F. (Growth Factors 2009)
    10. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PubMed id 21833088)1, 4  ....Compston A. (Nature 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6198 HGNC: 10436 AceView: RPS6KB1 Ensembl:ENSG00000108443 euGenes: HUgn6198
    ECgene: RPS6KB1 Kegg: 6198 H-InvDB: RPS6KB1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RPS6KB1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RPS6KB1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RPS6KB1 gene:
    Search GeneIP for patents involving RPS6KB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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