Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPS6KB1 Gene

protein-coding   GIFtS: 73
GCID: GC17P057970

Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1

(Previous names: ribosomal protein S6 kinase, 70kD, polypeptide 1)
(Previous symbol: STK14A)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 11 2     p70(S6K)-alpha2
STK14A1 2 3     p70-S6K2
S6K12 3 5     p70-alpha2
Ribosomal Protein S6 Kinase I2 3     Ribosomal Protein S6 Kinase Beta-12
Serine/Threonine-Protein Kinase 14A2 3     Serine/Threonine Kinase 14 Alpha2
S6K-beta-12 3     70 KDa Ribosomal Protein S6 Kinase 13
P70 S6KA2 3     P70S6K13
EC 2.7.11.13 8     P70 Ribosomal S6 Kinase Alpha3
Ribosomal Protein S6 Kinase, 70kD, Polypeptide 11     P70 S6 Kinase Alpha3
PS6K2     P70 S6K-Alpha3
S6K2     P70-S6K 13
P70 S6 Kinase, Alpha2     EC 2.7.118

External Ids:    HGNC: 104361   Entrez Gene: 61982   Ensembl: ENSG000001084437   OMIM: 6089385   UniProtKB: P234433   

Export aliases for RPS6KB1 gene to outside databases

Previous GC identifers: GC17M060023 GC17P060420 GC17P058312 GC17P058444 GC17P055325 GC17P053343


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RPS6KB1 Gene:
This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein
responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell
proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript
variants have been observed. The use of alternative translation start sites results in isoforms with longer or
shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on
chromosome 17. (provided by RefSeq, Jan 2013)

GeneCards Summary for RPS6KB1 Gene: 
RPS6KB1 (ribosomal protein S6 kinase, 70kDa, polypeptide 1) is a protein-coding gene. Diseases associated with RPS6KB1 include kidney angiomyolipoma, and tuberous sclerosis, and among its related super-pathways are Signal transduction AKT signaling and IL-9 Signaling Pathways. GO annotations related to this gene include ribosomal protein S6 kinase activity and protein kinase activity. An important paralog of this gene is RPS6KA6.

UniProtKB/Swiss-Prot: KS6B1_HUMAN, P23443
Function: Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and
nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis
through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the
pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3
translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin
complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation. The active form then
phosphorylates and activates several substrates in the preinitiation complex, including the EIF2B complex and the
cap-binding complex component EIF4B. Also controls translation initiation by phosphorylating a negative regulator
of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis. Promotes initiation of the pioneer
round of protein synthesis by phosphorylating POLDIP3/SKAR. In response to IGF1, activates translation elongation
by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2. Also plays a
role in feedback regulation of mTORC2 by mTORC1 by phosphorylating RICTOR, resulting in the inhibition of mTORC2
and AKT1 signaling. Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its
pro-apoptotic function. Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex. The
free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at 'Thr-412', which is proposed to be a negative
feedback mechanism for the RPS6KB1 anti-apoptotic function. Mediates TNF-alpha-induced insulin resistance by
phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1. In cells lacking
functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B. May be involved in cytoskeletal
rearrangement through binding to neurabin

summary for RPS6KB1 Gene:
p70 ribosomal S6 kinase (S6K) exists as two isoforms - S6K1 and S6K2 - which are activated by mitogenic
stimuli such as growth factors, insulin and cytokines. In turn, p70 S6K phosphorylates the ribosomal protein
S6. The S6K1 isoform also phosphorylates other proteins involved in the cell's translational machinery,
including elF4B (initiation factor); eEF2K (elongation factor 2 kinase); and SKAR (RNA binding protein). As
such, it is thought that S6K1 may be directly involved in cell growth and when considered alongside its
position downstream of the PI3K and mTOR pathways, this activity makes S6K1 a potential target for cancer
therapy.

Gene Wiki entry for RPS6KB1 (P70-S6 Kinase 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPS6KB1 gene promoter:
         NF-1   NF-1/L   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   YY1   CREB   E2F   E2F-1   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPS6KB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RPS6KB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS6KB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.1   Ensembl cytogenetic band:  17q23.1   HGNC cytogenetic band: 17q23.1

RPS6KB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS6KB1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P057970:  view genomic region     (about GC identifiers)

Start:
57,970,443 bp from pter      End:
58,027,925 bp from pter
Size:
57,483 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KS6B1_HUMAN, P23443 (See protein sequence)
Recommended Name: Ribosomal protein S6 kinase beta-1  
Size: 525 amino acids; 59140 Da
Subunit: Interacts with PPP1R9A/neurabin-1 (By similarity). Interacts with RPTOR. Interacts with IRS1. Interacts
with EIF3B and EIF3C. Interacts with POLDIP3 and TRAF4
Subcellular location: Cell junction, synapse, synaptosome (By similarity). Mitochondrion outer membrane.
Mitochondrion. Note=Colocalizes with URI1 at mitochondrion
Subcellular location: Isoform Alpha I: Nucleus. Cytoplasm
Subcellular location: Isoform Alpha II: Cytoplasm
3 PDB 3D structures from and Proteopedia for RPS6KB1:
3A60 (3D)        3A61 (3D)        3A62 (3D)    
Alternative initiation: 2 isoforms:  P23443-1   P23443-2   

Explore the universe of human proteins at neXtProt for RPS6KB1: NX_P23443

Explore proteomics data for RPS6KB1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation at Thr-412 is regulated by mTORC1. The phosphorylation at this site is maintained by an
    agonist-dependent autophosphorylation mechanism (By similarity). Activated by phosphorylation at Thr-252 by
    PDPK1. Dephosphorylation by PPP1CC at Thr-412 in mitochondrion
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P23443

  • 4/19 DME Specific Peptides for RPS6KB1 (P23443) (see all 19)
     YMAPEIL  LGKGGYG  DFGLCKE  SEEDVSQ 

    RPS6KB1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RPS6KB1 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001258971.1  NP_001258972.1  NP_001258973.1  NP_001258989.1  NP_003152.1  

    ENSEMBL proteins: 
     ENSP00000468058   ENSP00000441993   ENSP00000466562   ENSP00000384335   ENSP00000225577  
     ENSP00000464805   ENSP00000376744  
    Reactome Protein details: P23443
    Human Recombinant Protein Products for RPS6KB1: 
    EMD Millipore Purified and/or Recombinant RPS6KB1 Protein
    R&D Systems Recombinant & Natural Proteins for RPS6KB1 (p70 S6 Kinase)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RPS6KB1
    OriGene Protein Over-expression Lysate for RPS6KB1
    OriGene MassSpec for RPS6KB1 
    OriGene Custom Protein Services for RPS6KB1
    GenScript Custom Purified and Recombinant Proteins Services for RPS6KB1
    Novus Biologicals RPS6KB1 Proteins
    Novus Biologicals RPS6KB1 Lysates
    Sino Biological Recombinant Protein for RPS6KB1
    Sino Biological Cell Lysate for RPS6KB1 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA19085255
    GO:0005739mitochondrion IDA17936702
    GO:0005741mitochondrial outer membrane IEA--
    GO:0005829cytosol TAS--

    RPS6KB1 for ontologies           About GeneDecksing



    RPS6KB1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of RPS6KB1
    R&D Systems Antibodies for RPS6KB1 (p70 S6 Kinase)
    Cell Signaling Technology (CST) Antibodies for RPS6KB1  (p70S6K)
    OriGene Antibodies for RPS6KB1
    OriGene Custom Antibody Services for RPS6KB1
    GenScript Custom Superior Antibodies Services for RPS6KB1
    Novus Biologicals RPS6KB1 Antibodies
    Abcam antibodies for RPS6KB1
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for RPS6KB1
    LSBio Antibodies in human, mouse, rat for RPS6KB1 

    Assay Products for RPS6KB1: 
    EMD Millipore Kits and Assays for the Analysis of RPS6KB1
    OriGene Custom Assay Services for RPS6KB1
    R&D Systems ELISAs for RPS6KB1 (p70 S6 Kinase)         (see all)
    GenScript RPS6KB1-Activity-based Kinase Assay for Compound Screening
    Cell Signaling Technology (CST) Sandwich ELISA Kits for RPS6KB1 (p70S6K)
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: ribosomal protein S6 kinase, 70kDa, polypeptide 1 
    p70 subfamily
    Other AGC kinases

    5/8 InterPro protein domains (see all 8):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR016238 Ribosomal_S6_kinase
     IPR000961 AGC-kinase_C
     IPR011009 Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry P23443

    ProtoNet protein and cluster: P23443

    1 Blocks protein domain: IPB000961 Protein kinase C-terminal domain

    UniProtKB/Swiss-Prot: KS6B1_HUMAN, P23443
    Domain: The autoinhibitory domain is believed to block phosphorylation within the AGC-kinase C-terminal domain and
    the activation loop
    Domain: The TOS (TOR signaling) motif is essential for activation by mTORC1 (By similarity)
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 protein kinase domain


    RPS6KB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KS6B1_HUMAN, P23443
    Function: Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and
    nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis
    through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the
    pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3
    translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin
    complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation. The active form then
    phosphorylates and activates several substrates in the preinitiation complex, including the EIF2B complex and the
    cap-binding complex component EIF4B. Also controls translation initiation by phosphorylating a negative regulator
    of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis. Promotes initiation of the pioneer
    round of protein synthesis by phosphorylating POLDIP3/SKAR. In response to IGF1, activates translation elongation
    by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2. Also plays a
    role in feedback regulation of mTORC2 by mTORC1 by phosphorylating RICTOR, resulting in the inhibition of mTORC2
    and AKT1 signaling. Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its
    pro-apoptotic function. Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex. The
    free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at 'Thr-412', which is proposed to be a negative
    feedback mechanism for the RPS6KB1 anti-apoptotic function. Mediates TNF-alpha-induced insulin resistance by
    phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1. In cells lacking
    functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B. May be involved in cytoskeletal
    rearrangement through binding to neurabin
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activation requires multiple phosphorylation events on serine/threonine residues. Activation
    appears to be first mediated by phosphorylation of multiple sites in the autoinhibitory domain, which facilitates
    phosphorylation at Thr-412, disrupting the autoinhibitory mechanism and allowing phosphorylation of Thr-252 by
    PDPK1. The active conformation of the kinase is believed to be stabilized by a mechanism involving three
    conserved phosphorylation sites located in the kinase domain activation loop (Thr-252) and in the AGC-kinase
    C-terminal domain (Ser-394 in the middle of the tail/linker region and Thr-412 within a hydrophobic motif at its
    end). Activated by mTORC1; isoform Alpha I and isoform Alpha II are sensitive to rapamycin, which inhibits
    activating phosphorylation at Thr-412. Activated by PDPK1

         Genatlas biochemistry entry for RPS6KB1:
    ribosomal protein S6 kinase,70kDa,polypeptide 1,widely expressed,not involved in vivo in the phosphorylation of
    RPS6,mediating protein synthesis initiation and elongation induced by hormones or growth factors,maybe playing an
    essential regulatory role in protein synthesis during cell proliferation

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA17936702
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004711ribosomal protein S6 kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI12150926
         
    RPS6KB1 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for RPS6KB1:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Decreased viability with pacli  Increased cell death HMECs cel 
     Upregulation of Wnt/beta-caten 

         12 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rps6kb1):
     cardiovascular system  cellular  embryogenesis  endocrine/exocrine gland  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  muscle 
     reproductive system  tumorigenesis 

    RPS6KB1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for RPS6KB1: Rps6kb1tm1Nte Rps6kb1tm1Gtho

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RPS6KB1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RPS6KB1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RPS6KB1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RPS6KB1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPS6KB1
    8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate RPS6KB1 (see all 55):
    hsa-miR-579 hsa-miR-100* hsa-miR-429 hsa-miR-605 hsa-miR-128 hsa-miR-218 hsa-miR-507 hsa-miR-3161
    SwitchGear 3'UTR luciferase reporter plasmidRPS6KB1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RPS6KB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS6KB1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RPS6KB1
    Sirion Biotech Customized adenovirus for overexpression of RPS6KB1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RPS6KB1 (see all 12)
    OriGene ORF clones in mouse, rat for RPS6KB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RPS6KB1 (NM_003161)
    Sino Biological Human cDNA Clone for RPS6KB1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPS6KB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS6KB1
    Sirion Biotech Customized lentivirus for stable overexpression of RPS6KB1 
                         Customized lentivirus expression plasmids for stable overexpression of RPS6KB1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RPS6KB1
    Search LifeMap BioReagents cell lines for RPS6KB1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS6KB1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RPS6KB1 About   (see all 69)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Development IGF-RI signaling
    Development IGF-RI signaling0.49
    Development IGF-1 receptor signaling0.48
    Signal transduction AKT signaling0.49
    2Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
    IL-9 Signaling Pathways0.90
    IL-2 Signaling Pathways0.88
    IL-7 Signaling Pathways0.90
    IL-4 Signaling Pathways0.84
    IL-21 Signaling Pathways0.90
    Development Thrombopoietin-regulated cell processes0.38
    Common Cytokine Receptor Gamma-Chain Family Signaling Pathways0.90
    Adipocytokines & Insulin Signaling0.34
    3Translation Insulin regulation of translation
    Translation Insulin regulation of translation0.59
    Development CNTF receptor signaling0.43
    Regulation of lipid metabolism Insulin signaling:generic cascades0.59
    Development Growth hormone signaling via PI3K/AKT and MAPK cascades0.34
    Transcription Receptor-mediated HIF regulation0.51
    mTOR signaling pathway0.34
    Translation Regulation activity of EIF4F0.44
    Insulin signaling pathway0.31
    4Energy dependent regulation of mTOR by LKB1-AMPK
    mTOR signalling0.63
    TOR signaling0.33
    PKB-mediated events0.61
    5ErbB signaling pathway
    ErbB signaling pathway0.52
    ErbB signaling pathway0.52

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/18 EMD Millipore Pathways for RPS6KB1 (see all 18)
        Translation Translation regulation by Alpha-1 adrenergic receptors
    Development Growth hormone signaling via PI3K/AKT and MAPK cascades
    Development Endothelin-1/EDNRA transactivation of EGFR
    Regulation of lipid metabolism Insulin signaling-generic cascades
    Translation Insulin regulation of translation

    5/10 R&D Systems Pathways for RPS6KB1 (see all 10)
        IL-21 Signaling Pathways
    IL-2 Signaling Pathways
    IL-4 Signaling Pathways
    Adipocytokines & Insulin Signaling
    Akt Signaling Pathway

    5/25 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RPS6KB1 (see all 25)
        FLT3 Signaling
    UVB-Induced MAPK Signaling
    IL-4 Pathway
    Interferon Pathway
    Glioblastoma Multiforme

    1 Cell Signaling Technology (CST) Pathway for RPS6KB1
        Translational Control

    5/18 GeneGo (Thomson Reuters) Pathways for RPS6KB1 (see all 18)
        Development Endothelin-1/EDNRA transactivation of EGFR
    Development CNTF receptor signaling
    Signal transduction AKT signaling
    Translation Insulin regulation of translation
    Transcription Receptor-mediated HIF regulation

    5/29 BioSystems Pathways for RPS6KB1 (see all 29)
        TOR signaling
    G13 Signaling Pathway
    Insulin Signaling
    ErbB signaling pathway
    AMPK signaling

    1 Sino Biological Pathway for RPS6KB1 
        TGF-beta Signaling Pathway

    5/14        Reactome Pathways for RPS6KB1 (see all 14)
        PI3K Cascade
    IGF1R signaling cascade
    S6K1 signalling
    mTOR signalling
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)


    5/9         Kegg Pathways  (Kegg details for RPS6KB1) (see all 9):
        ErbB signaling pathway
    HIF-1 signaling pathway
    mTOR signaling pathway
    PI3K-Akt signaling pathway
    TGF-beta signaling pathway


    RPS6KB1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RPS6KB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/107 Interacting proteins for RPS6KB1 (P234431, 2, 3 ENSP000002255774) via UniProtKB, MINT, STRING, and/or I2D (see all 107)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COASYQ130572, 3MINT-51122 MINT-51123 MINT-51062 MINT-51063 I2D: score=4 
    MAPTP106362, 3, ENSP000003408204MINT-74874 MINT-74872 I2D: score=1 STRING: ENSP00000340820
    PDPK1O155302, 3, ENSP000003442204MINT-14377 I2D: score=3 STRING: ENSP00000344220
    CLEC3BP054522, 3, ENSP000002961304MINT-8269989 I2D: score=2 STRING: ENSP00000296130
    DPPA4Q7L1902, 3, ENSP000003353064MINT-8270000 I2D: score=2 STRING: ENSP00000335306
    About this table

    Gene Ontology (GO): 5/45 biological process terms (GO ID links to tree view) (see all 45):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle IMP14673156
    GO:0003009skeletal muscle contraction IEA--
    GO:0006468protein phosphorylation IDA19085255
    GO:0006915apoptotic process IEA--
    GO:0007165signal transduction TAS1922062

    RPS6KB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RPS6KB1 for compounds           About GeneDecksing

    EMD Millipore small molecules for RPS6KB1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for RPS6KB1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BRD 7389p90 ribosomal S6 kinase inhibitor[376382-11-5]
    PF 4708671S6K1 inhibitor[1255517-76-0]
    SL 0101-1Selective p90 ribosomal S6 kinase (RSK) inhibitor[77307-50-7]

    2 HMDB Compounds for RPS6KB1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    10/75 Novoseek inferred chemical compound relationships for RPS6KB1 gene (see all 75)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rapamycin 95.5 518 9271419 (6), 17660033 (5), 14871980 (5), 8389370 (5) (see all 99)
    wortmannin 82.5 75 7545671 (3), 9468542 (2), 11446769 (2), 12296652 (2) (see all 50)
    ly294002 82.4 39 12242656 (3), 9367837 (2), 13679036 (1), 16139919 (1) (see all 31)
    phosphatidylinositol 81.9 96 18948408 (4), 12183455 (3), 7961833 (3), 11279232 (3) (see all 56)
    everolimus 74 21 14729632 (4), 20204306 (2), 18332467 (2), 19471857 (1) (see all 8)
    phosphoinositide 70.3 35 8621477 (2), 15816524 (2), 7826337 (2), 11027274 (2) (see all 20)
    threonine 66.3 31 18461003 (3), 12555062 (2), 12713446 (2), 9751223 (2) (see all 23)
    serine 59.5 50 18948408 (3), 20203102 (3), 16914728 (3), 18952604 (2) (see all 29)
    pd 98,059 58.6 12 11279232 (2), 12242656 (1), 11368346 (1), 19474060 (1) (see all 11)
    phosphatidylinositol-3,4,5-trisphosphate 54 1 9768361 (1)

    Search CenterWatch for drugs/clinical trials and news about RPS6KB1 / KS6B1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RPS6KB1 gene (5 alternative transcripts): 
    NM_001272042.1  NM_001272043.1  NM_001272044.1  NM_001272060.1  NM_003161.3  

    Unigene Cluster for RPS6KB1:

    Ribosomal protein S6 kinase, 70kDa, polypeptide 1
    Hs.463642  [show with all ESTs]
    Unigene Representative Sequence: NM_001272044
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000472940 ENST00000477179 ENST00000443572 ENST00000489824 ENST00000406116(uc010ddj.2)
    ENST00000225577(uc002ixy.3 uc010wom.2 uc010won.2 uc010woo.2)
    ENST00000592726 ENST00000587622 ENST00000590928 ENST00000475155 ENST00000587061
    ENST00000393021

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPS6KB1
    8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate RPS6KB1 (see all 55):
    hsa-miR-579 hsa-miR-100* hsa-miR-429 hsa-miR-605 hsa-miR-128 hsa-miR-218 hsa-miR-507 hsa-miR-3161
    SwitchGear 3'UTR luciferase reporter plasmidRPS6KB1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RPS6KB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS6KB1
    Clone
    Products:
         
    OriGene clones in human, mouse for RPS6KB1 (see all 12)
    OriGene ORF clones in mouse, rat for RPS6KB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RPS6KB1 (NM_003161)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPS6KB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS6KB1
    Sirion Biotech Customized lentivirus for stable overexpression of RPS6KB1 
                         Customized lentivirus expression plasmids for stable overexpression of RPS6KB1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RPS6KB1
    OriGene qSTAR qPCR primer pairs in human, mouse for RPS6KB1
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RPS6KB1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS6KB1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS6KB1

    Additional mRNA sequence: 

    AK026730.1 AK091503.1 AK293247.1 AK297147.1 AK300202.1 AK312875.1 BC030763.2 BC053365.1 
    M60724.1 

    11 DOTS entries:

    DT.316003  DT.95270971  DT.100785618  DT.91858174  DT.121012844  DT.121012842  DT.65285220  DT.91746169 
    DT.92029419  DT.100683971  DT.91864442 

    24/230 AceView cDNA sequences (see all 230):

    AA828362 BE049560 BX500254 BM802717 AI262530 AA425446 AL710406 AI620614 
    AA806019 AI754381 AW304374 BE877872 BF439519 AK097658 BG287629 AI278237 
    BU160729 BP365397 BP359158 AA830851 AA805666 CR604237 AL602438 AU103944 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPS6KB1 expression in normal human tissues (normalized intensities)      RPS6KB1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAAATGTTG
    RPS6KB1 Expression
    About this image


    RPS6KB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Gonad
             Testis Somatic Cells Primitive Gonad
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             bone marrow cd34+   
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Primary Oocyte Primordial Follicle
     
     Testis (Reproductive System)
             Testis Somatic Cells Primitive Gonad
     
     Umbilical Cord (Extraembryonic Tissues)
             stem cells (umbilical cord cd34+)   

    See RPS6KB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPS6KB1

    SOURCE GeneReport for Unigene cluster: Hs.463642

    UniProtKB/Swiss-Prot: KS6B1_HUMAN, P23443
    Tissue specificity: Widely expressed

        SABiosciences Expression via Pathway-Focused PCR Arrays including RPS6KB1 (see all 8): 
              mTOR Signaling in human mouse rat
              Insulin Resistance in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              Autophagy in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RPS6KB1
    OriGene qSTAR qPCR primer pairs in human, mouse for RPS6KB1
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RPS6KB1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS6KB1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS6KB1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS6KB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPS6KB1 gene from 10/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rps6kb11 , 5 ribosomal protein S6 kinase, polypeptide 11, 5 94.6(n)1
    99.43(a)1
      11 (51.82 cM)5
    725081  NM_001114334.11  NP_001107806.11 
     864988715 
    chicken
    (Gallus gallus)
    Aves RPS6KB11 ribosomal protein S6 kinase, 70kDa, polypeptide 1 88.58(n)
    97.21(a)
      417637  NM_001030721.1  NP_001025892.1 
    lizard
    (Anolis carolinensis)
    Reptilia RPS6KB16
    Uncharacterized protein
    95(a)
    1 ↔ 1
    GL343470.1(194051-214697)
    African clawed frog
    (Xenopus laevis)
    Amphibia rps6kb1-A2 ribosomal protein S6 kinase, 70kDa, polypeptide 1 79.25(n)    AJ131521.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.245282 Danio rerio cDNA clone MGC55713 IMAGE3815976, complete cds less 80.49(n)    BC046888.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta S6k1 , 3 cell growth and/or maintenance protein
    serine/threonine kinase less3
    RPS6-p70-protein kinase1
    72(a)
    (best of 2)3
    65.94(n)1
    73.22(a)1
      386541  NM_079217.21  NP_523941.21 
    worm
    (Caenorhabditis elegans)
    Secernentea Y47D3A.163
    rsks-11
    ribosomal protein S6 kinase3
    Protein RSKS-11
    60(a)
    (best of 3)3
    61.1(n)1
    63.09(a)1
      III(11316958-11322832)3
    1765541  NM_067046.21  NP_499447.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YPK3(YBR028C)4 An AGC kinase phosphorylated by cAMP-dependent protein kinase (PKA) in a TORC1-dependent manner less   --   2(296002-294425) 852316  NP_009584.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons S6K21 serine/threonine protein kinase 2 52.28(n)
    47.27(a)
      820019  NM_111706.3  NP_187484.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g03340001 hypothetical protein 54.9(n)
    48.75(a)
      4332748  NM_001056562.1  NP_001050027.1 


    ENSEMBL Gene Tree for RPS6KB1 (if available)
    TreeFam Gene Tree for RPS6KB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPS6KB1 gene
    RPS6KA62  AKT12  SGK32  C8orf44-SGK32  SGK22  RPS6KA12  RPS6KA52  AKT32  
    RPS6KA42  SGK12  RPS6KB22  RPS6KA22  RPS6KA32  AKT22  
    18/78 SIMAP similar genes for RPS6KB1 using alignment to 8 protein entries:     KS6B1_HUMAN (see all proteins) (see all similar genes):
    RPS6KB2    RPS6KA2    RPS6KA3    AKT3    PRKCE    RPS6KA1
    RPS6KA4    SGK2    PKN2    PRKCI    MARK4    PRKCQ
    PRKCH    PRKACA    RPS6KA6    PRKCB    PRKCZ    AKT2

    RPS6KB1 for paralogs           About GeneDecksing


    5/6 Pseudogenes.org Pseudogenes for RPS6KB1 (see all 6)
    PGOHUM00000237046 PGOHUM00000237050 PGOHUM00000237051 PGOHUM00000237059 PGOHUM00000237134


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1070 SNPs in RPS6KB1 are shown (see all 1070)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356284
    A colorectal cancer sample4--see VAR_0356282 G E mis40--------
    VAR_0406404
    ----see VAR_0406402 R C mis40--------
    VAR_0406394
    ----see VAR_0406392 M I mis40--------
    VAR_0406414
    ----see VAR_0406412 W C mis40--------
    VAR_0406424
    ----see VAR_0406422 S A mis40--------
    rs1127924011,2
    C--57972697(+) TTTTTC/G/TTTTGA 5 -- int11CSA 2
    rs116557551,2
    C,F,A,H--57972849(+) ggctaC/Attttt 5 -- int15Minor allele frequency- A:0.12NA EA 250
    rs1135765831,2
    C--57980678(+) AAAAG-/AAAAAA 5 -- int11Minor allele frequency- A:0.50CSA 2
    rs603563501,2
    C--57981782(+) CGGAG-/TCTGCC 5 -- int10--------
    rs602965681,2
    C--57981786(+) AGCTG-/CCTCTA 5 -- int10--------

    HapMap Linkage Disequilibrium report for RPS6KB1 (57970443 - 58027925 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for RPS6KB1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv471544CNV Duplication19718026
    nsv428348CNV Gain18775914
    nsv471702CNV Gain15918152
    esv24411CNV Gain19812545
    nsv833502CNV Gain17160897
    nsv9576CNV Gain+Loss18304495
    dgv996e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): RPS6KB1
    1 SABiosciences Cancer Mutation PCR Assay for RPS6KB1:
    Cosmic IdAA Change
    32843p.G289E
    1 SABiosciences qBiomarker Copy Number PCR Array containing RPS6KB1:
    Kinases & Phosphatases
    SeqTarget long-range PCR primers for resequencing RPS6KB1
    DNA2.0 Custom Variant and Variant Library Synthesis for RPS6KB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608938    OMIM disorders: --

    20/85 diseases for RPS6KB1 (see all 85):    About MalaCards
    kidney angiomyolipoma    tuberous sclerosis    tuberous sclerosis complex    glucocorticoid resistance
    angiomyolipoma    placental choriocarcinoma    embryonal rhabdomyosarcoma    lymphangioleiomyomatosis
    phaeochromocytoma    malignant peripheral nerve sheath tumor    rhabdomyosarcoma    ataxia telangiectasia
    anaplastic large cell lymphoma    small cell carcinoma    insulin resistance    gastrointestinal stromal tumor
    choriocarcinoma    endometrial adenocarcinoma    adult t-cell leukemia    malignant mesothelioma

    2 diseases from the University of Copenhagen DISEASES database for RPS6KB1:
    Cancer     Tuberous sclerosis

    RPS6KB1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/44 Novoseek inferred disease relationships for RPS6KB1 gene (see all 44)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tuberous sclerosis 75.5 9 16914728 (2), 15249583 (1), 12384518 (1), 18094073 (1) (see all 6)
    tumors 44.3 52 15112576 (3), 15627062 (3), 12733712 (2), 16489002 (2) (see all 30)
    cancer 42.9 28 12433206 (4), 17624310 (2), 17452018 (1), 12733712 (1) (see all 16)
    glioblastoma 37.2 1 20423992 (1)
    rhabdomyosarcoma 36.4 5 12000755 (1), 15735038 (1), 17585318 (1), 8909805 (1)
    retinoblastoma 33.9 1 11426655 (1)
    insulin resistance 33.2 24 16753575 (3), 18948408 (3), 18252807 (2), 18952604 (1) (see all 11)
    hamartoma 28.5 1 16914728 (1)
    hypertrophy 26.6 14 9242178 (4), 15963500 (2), 18160324 (2), 16717578 (1) (see all 7)
    ataxia telangiectasia 24.2 1 10971657 (1)

    Genetic Association Database (GAD): RPS6KB1
    Human Genome Epidemiology (HuGE) Navigator: RPS6KB1 (11 documents)

    Export disorders for RPS6KB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPS6KB1 gene, integrated from 9 sources (see all 792):
    (articles sorted by number of sources associating them with RPS6KB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini. (PubMed id 1922062)1, 2, 3 Grove J.... Woodgett J.R. (1991)
    2. S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2. (PubMed id 18952604)1, 2, 9 Zhang J....Ye J. (2008)
    3. mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. (PubMed id 16286006)1, 2, 9 Holz M.K.... Blenis J. (2005)
    4. mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E. (PubMed id 14673156)1, 2, 9 Fingar D.C....Blenis J. (2004)
    5. SKAR is a specific target of S6 kinase 1 in cell growth control. (PubMed id 15341740)1, 2, 9 Richardson C.J....Blenis J. (2004)
    6. Phosphorylation and activation of p70s6k by PDK1. (PubMed id 9445476)1, 2, 9 Pullen N....Thomas G. (1998)
    7. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. (PubMed id 12150926)1, 2, 9 Hara K.... Yonezawa K. (2002)
    8. Structural basis of human p70 ribosomal S6 kinase-1 r egulation by activation loop phosphorylation. (PubMed id 19864428)1, 2, 9 Sunami T....Sharma S. (2010)
    9. Regulation and localization of ribosomal protein S6 kinase 1 isoforms. (PubMed id 19085255)1, 2, 9 Kim D....Meric-Bernstam F. (2009)
    10. Genetic risk and a primary role for cell-mediated immu ne mechanisms in multiple sclerosis. (PubMed id 21833088)1, 4  ....Compston A. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6198 HGNC: 10436 AceView: RPS6KB1 Ensembl:ENSG00000108443 euGenes: HUgn6198
    ECgene: RPS6KB1 Kegg: 6198 H-InvDB: RPS6KB1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPS6KB1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RPS6KB1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RPS6KB1 gene:
    Search GeneIP for patents involving RPS6KB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore small molecules (inhibitor) for RPS6KB1
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of RPS6KB1
     EMD Millipore Purified and/or Recombinant RPS6KB1 Protein
     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore Kits and Assays for the Analysis of RPS6KB1
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for RPS6KB1 (p70 S6 Kinase)   Browse Cell Culture Products  
     ELISAs for RPS6KB1 (p70 S6 Kinase)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for RPS6KB1 (p70 S6 Kinase)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for RPS6KB1 (p70 S6 Kinase)  
     OriGene Antibodies for RPS6KB1   OriGene RNAi products in human, mouse, rat for RPS6KB1  
     OriGene qPCR primer pairs and template standards for RPS6KB1   OriGene Protein Over-expression Lysate for RPS6KB1  
     OriGene MassSpec something-or-other for RPS6KB1   OriGene clones in human, mouse for RPS6KB1  
     OriGene qSTAR qPCR primer pairs in human, mouse for RPS6KB1   OriGene Purified Protein for RPS6KB1  
     OriGene ORF clones in mouse, rat for RPS6KB1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RPS6KB1   OriGene Custom Protein Services for RPS6KB1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RPS6KB1
     QIAGEN SeqTarget long-range PCR primers for resequencing RPS6KB1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS6KB1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS6KB1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS6KB1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS6KB1
     GenScript Custom Purified and Recombinant Proteins Services for RPS6KB1 GenScript cDNA clones with any tag delivered in your preferred vector for RPS6KB1
     GenScript RPS6KB1-Activity-based Kinase Assay for Compound Screening GenScript Custom Superior Antibodies Services for RPS6KB1
     GenScript Custom overexpressing Cell Line Services for RPS6KB1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for RPS6KB1  (p70S6K)

     Regulatory tfbs in RPS6KB1 promoter
     Search Chromatin IP Primers for RPS6KB1
     RT2 qPCR Primer Assay in human, mouse / rat RPS6KB1
     GNC Network for RPS6KB1
     SABiosciences PCR Arrays including human, mouse / rat RPS6KB1
     Tocris compounds for RPS6KB1
     Proteins and Antibodies for RPS6KB1
     Cell Lysates for RPS6KB1
     cDNA Clones for RPS6KB1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RPS6KB1 antibodies
     RPS6KB1 proteins
     RPS6KB1 lysates
     Antibodies for RPS6KB1
     See all of Abcam's Antibodies, Kits and Proteins for RPS6KB1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for RPS6KB1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS6KB1
     SwitchGear 3'UTR luciferase reporter plasmids for RPS6KB1
     SwitchGear Promoter luciferase reporter plasmids for RPS6KB1
     ThermoFisher Antibody for RPS6KB1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS6KB1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for RPS6KB1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RPS6KB1
    Customized:
     lentivirus for stable overexpression of RPS6KB1
     lentivirus expression plasmids for stable overexpression of RPS6KB1
     adenovirus for overexpression of RPS6KB1
     LSBio Antibodies in human, mouse, rat for RPS6KB1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RPS6KB1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4