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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPS6KB1 Gene

protein-coding   GIFtS: 71
GCID: GC17P057970

ribosomal protein S6 kinase, 70kDa, polypeptide 1

(Previous names: ribosomal protein S6 kinase, 70kD, polypeptide 1 )
(Previous symbol: STK14A)
 Explore 90 diseases affiliated with
RPS6KB1 via
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Biological research products
for RPS6KB1    

Aliases
for RPS6KB1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 11 2     P70 S6 Kinase, Alpha2
S6K11 2 3 5     P70-S6K1
STK14A1 2 3     P70-Alpha1
PS6K1 2     Ribosomal Protein S6 Kinase Beta-12
P70(S6K)-Alpha1     Serine/Threonine Kinase 14 Alpha2
Ribosomal Protein S6 Kinase I2 3     70 KDa Ribosomal Protein S6 Kinase 13
Serine/Threonine-Protein Kinase 14A2 3     P70S6K13
S6K-Beta-11     P70 Ribosomal S6 Kinase Alpha3
P70 S6KA2 3     P70 S6 Kinase Alpha3
EC 2.7.11.13 8     P70 S6K-Alpha3
Ribosomal Protein S6 Kinase, 70kD, Polypeptide 11     P70-S6K 13
S6K2     EC 2.7.118

External Ids:    HGNC: 104361   Entrez Gene: 61982   Ensembl: ENSG000001084437   OMIM: 6089385   UniProtKB: P234433   

Export aliases for RPS6KB1 gene to outside databases

Previous GC identifers: GC17M060023 GC17P060420 GC17P058312 GC17P058444 GC17P055325 GC17P053343


Summaries
for RPS6KB1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RPS6KB1:
This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds
to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation.
Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been
observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which
may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. (provided by
RefSeq, Jan 2013)

UniProtKB/Swiss-Prot: KS6B1_HUMAN, P23443
Function: Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and
nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through
phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of
BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation
complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTORC1) leads to
dissociation from the EIF3 complex and activation. The active form then phosphorylates and activates several
substrates in the preinitiation complex, including the EIF2B complex and the cap-binding complex component EIF4B. Also
controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for
ubiquitination and subsequent proteolysis. Promotes initiation of the pioneer round of protein synthesis by
phosphorylating POLDIP3/SKAR. In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase
(EEF2K), which leads to its inhibition and thus activation of EEF2. Also plays a role in feedback regulation of mTORC2
by mTORC1 by phosphorylating RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling. Mediates cell survival
by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function. Phosphorylates
mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex. The free mitochondrial PPP1CC can then
dephosphorylate RPS6KB1 at 'Thr-412', which is proposed to be a negative feedback mechanism for the RPS6KB1
anti-apoptotic function. Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine
residues, resulting in accelerated degradation of IRS1. In cells lacking functional TSC1-2 complex, constitutively
phosphorylates and inhibits GSK3B. May be involved in cytoskeletal rearrangement through binding to neurabin

summary for RPS6KB1:
p70 ribosomal S6 kinase (S6K) exists as two isoforms - S6K1 and S6K2 - which are activated by mitogenic
stimuli such as growth factors, insulin and cytokines. In turn, p70 S6K phosphorylates the ribosomal protein
S6. The S6K1 isoform also phosphorylates other proteins involved in the cell's translational machinery,
including elF4B (initiation factor); eEF2K (elongation factor 2 kinase); and SKAR (RNA binding protein). As
such, it is thought that S6K1 may be directly involved in cell growth and when considered alongside its
position downstream of the PI3K and mTOR pathways, this activity makes S6K1 a potential target
for cancer therapy.

Gene Wiki entry for RPS6KB1 (P70-S6 Kinase 1)


Genomic Views
for RPS6KB1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPS6KB1 gene promoter:
         NF-1   NF-1/L   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   YY1   CREB   E2F   E2F-1   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RPS6KB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RPS6KB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS6KB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.1   Ensembl cytogenetic band:  17q23.1   HGNC cytogenetic band: 17q23.1

RPS6KB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS6KB1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P057970:  view genomic region     (about GC identifiers)

Start:
 57,970,443 bp from pter      End:
 58,027,925 bp from pter
Size:
 57,483 bases      Orientation:
 plus strand

Proteins
for RPS6KB1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KS6B1_HUMAN, P23443 (See protein sequence)
Recommended Name: Ribosomal protein S6 kinase beta-1  
Size: 525 amino acids; 59140 Da
Subunit: Interacts with PPP1R9A/neurabin-1 (By similarity). Interacts with RPTOR. Interacts with IRS1. Interacts with
EIF3B and EIF3C. Interacts with POLDIP3 and TRAF4
Subcellular location: Cell junction, synapse, synaptosome (By similarity). Mitochondrion outer membrane. Mitochondrion.
Note=Colocalizes with URI1 at mitochondrion
Subcellular location: Isoform Alpha I: Nucleus. Cytoplasm
Subcellular location: Isoform Alpha II: Cytoplasm
3 PDB 3D structures from and Proteopedia for RPS6KB1:
3A60 (3D)        3A61 (3D)        3A62 (3D)    
Alternative initiation: 2 isoforms:  P23443-1   P23443-2   

Explore the universe of human proteins at neXtProt for RPS6KB1: NX_P23443

Post-translational modifications:

  • Phosphorylation at Thr-412 is regulated by mTORC1. The phosphorylation at this site is maintained by an
    • agonist-dependent autophosphorylation mechanism (By similarity). Activated by phosphorylation at Thr-252 by PDPK1.
    Dephosphorylation by PPP1CC at Thr-412 in mitochondrion1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P23443

    • 4/19 DME Specific Peptides for RPS6KB1 (P23443) (see all 19)
     YMAPEIL  LGKGGYG  DFGLCKE  SEEDVSQ 

    RPS6KB1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001258971.1  NP_001258972.1  NP_001258973.1  NP_001258989.1  NP_003152.1  

    ENSEMBL proteins: 
     ENSP00000468058   ENSP00000441993   ENSP00000466562   ENSP00000384335   ENSP00000225577  
     ENSP00000464805   ENSP00000376744  
    Reactome Protein details: P23443
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant RPS6KB1 Protein
    R&D Systems Recombinant & Natural Proteins for RPS6KB1 (p70 S6 Kinase)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: RPS6KB1
    OriGene Protein Over-expression Lysate: RPS6KB1
    OriGene Custom Protein Services for RPS6KB1 
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    Novus Biologicals RPS6KB1 Proteins
    Novus Biologicals RPS6KB1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005625soluble fraction ----
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA19085255
    GO:0005739mitochondrion IDA17936702
    GO:0005741mitochondrial outer membrane IEA--


    RPS6KB1 for ontologies           About GeneDecksing



    RPS6KB1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of RPS6KB1
    R&D Systems Antibodies for RPS6KB1 (p70 S6 Kinase)
    Cell Signaling Technology (CST) Antibodies for RPS6KB1  (p70S6K)
    OriGene Antibodies (see all 13): RPS6KB1
    OriGene Custom Antibody Services for RPS6KB1 
    GenScript Custom Superior Antibodies Services for RPS6KB1
    Novus Biologicals RPS6KB1 Antibodies
    Abcam antibodies for RPS6KB1 
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    ThermoFisher Antibodies for RPS6KB1

    Assay Products for RPS6KB1: 
    EMD Millipore Kits and Assays for the Analysis of RPS6KB1
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for RPS6KB1 (p70 S6 Kinase)         (see all)
    GenScript RPS6KB1-Activity-based Kinase Assay for Compound Screening
    Cell Signaling Technology (CST) Sandwich ELISA Kits for RPS6KB1 (p70S6K)
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for RPS6KB1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RPS6KB1 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR016238 Ribosomal_S6_kinase
     IPR000961 AGC-kinase_C
     IPR011009 Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry P23443

    ProtoNet protein and cluster: P23443

    1 Blocks protein family: IPB000961 Protein kinase C-terminal domain

    UniProtKB/Swiss-Prot: KS6B1_HUMAN, P23443
    Domain: The autoinhibitory domain is believed to block phosphorylation within the AGC-kinase C-terminal domain and the
    activation loop
    Domain: The TOS (TOR signaling) motif is essential for activation by mTORC1 (By similarity)
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 protein kinase domain


    Function
    for RPS6KB1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KS6B1_HUMAN, P23443
    Function: Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and
    nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through
    phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of
    BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation
    complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTORC1) leads to
    dissociation from the EIF3 complex and activation. The active form then phosphorylates and activates several
    substrates in the preinitiation complex, including the EIF2B complex and the cap-binding complex component EIF4B. Also
    controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for
    ubiquitination and subsequent proteolysis. Promotes initiation of the pioneer round of protein synthesis by
    phosphorylating POLDIP3/SKAR. In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase
    (EEF2K), which leads to its inhibition and thus activation of EEF2. Also plays a role in feedback regulation of mTORC2
    by mTORC1 by phosphorylating RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling. Mediates cell survival
    by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function. Phosphorylates
    mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex. The free mitochondrial PPP1CC can then
    dephosphorylate RPS6KB1 at 'Thr-412', which is proposed to be a negative feedback mechanism for the RPS6KB1
    anti-apoptotic function. Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine
    residues, resulting in accelerated degradation of IRS1. In cells lacking functional TSC1-2 complex, constitutively
    phosphorylates and inhibits GSK3B. May be involved in cytoskeletal rearrangement through binding to neurabin
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activation requires multiple phosphorylation events on serine/threonine residues. Activation appears
    to be first mediated by phosphorylation of multiple sites in the autoinhibitory domain, which facilitates
    phosphorylation at Thr-412, disrupting the autoinhibitory mechanism and allowing phosphorylation of Thr-252 by PDPK1.
    The active conformation of the kinase is believed to be stabilized by a mechanism involving three conserved
    phosphorylation sites located in the kinase domain activation loop (Thr-252) and in the AGC-kinase C-terminal domain
    (Ser-394 in the middle of the tail/linker region and Thr-412 within a hydrophobic motif at its end). Activated by
    mTORC1; isoform Alpha I and isoform Alpha II are sensitive to rapamycin, which inhibits activating phosphorylation at
    Thr-412. Activated by PDPK1

         Genatlas biochemistry entry for RPS6KB1:
    ribosomal protein S6 kinase,70kDa,polypeptide 1,widely expressed,not involved in vivo in the phosphorylation of
    RPS6,mediating protein synthesis initiation and elongation induced by hormones or growth factors,maybe playing an
    essential regulatory role in protein synthesis during cell proliferation

    Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

    miRNA
    Products:            		 OriGene 3'-UTR Clone: RPS6KB1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPS6KB1
    8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate RPS6KB1 (see all 55):
    hsa-miR-579 hsa-miR-100* hsa-miR-429 hsa-miR-605 hsa-miR-128 hsa-miR-218 hsa-miR-507 hsa-miR-3161
    SwitchGear 3'UTR luciferase reporter plasmid: RPS6KB1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPS6KB1 (see all 6)
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS6KB1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RPS6KB1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPS6KB1 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPS6KB1 (see all 5)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: RPS6KB1 (NM_003161)
    Sino Biological Human cDNA Clone for RPS6KB1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS6KB1 

    Cell Line
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    Search LifeMap BioReagents cell lines for RPS6KB1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS6KB1

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA18952604
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004711ribosomal protein S6 kinase activity IEA--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--


    RPS6KB1 for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for RPS6KB1:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Decreased viability with pacli  Increased cell death HMECs cel 
     Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-outs for RPS6KB1: Rps6kb1tm1Nte Rps6kb1tm1Gtho
         12 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Rps6kb1):
     cardiovascular system  cellular  embryogenesis  endocrine/exocrine gland  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  muscle 
     reproductive system  tumorigenesis 

    RPS6KB1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for RPS6KB1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/64 super-pathways (see all 64) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Development_CNTF receptor signaling
    8/14 pathways (see all 14)
    		Development_CNTF receptor signaling1.00
    		Translation Insulin regulation of translation0.35
    		Development CNTF receptor signaling1.00
    		Development_Growth hormone signaling via PI3K/AKT and MAPK cascades0.34
    		Transcription Receptor-mediated HIF regulation0.43
    		Development Growth hormone signaling via PI3K/AKT and MAPK cascades0.34
    		Transcription_Receptor-mediated HIF regulation0.43
    		Translation _Regulation of EIF4F activity0.32
    2IL-9 Signaling Pathways
    8/10 pathways (see all 10)
    		IL-9 Signaling Pathways1.00
    		IL-15 Signaling Pathways0.86
    		IL-21 Signaling Pathways0.90
    		IL-4 Signaling Pathways0.80
    		IL-7 Signaling Pathways0.90
    		Development_Thrombopoietin-regulated cell processes0.36
    		Common Cytokine Receptor Gamma-Chain Family Signaling Pathways0.90
    		Development Thrombopoietin-regulated cell processes0.36
    3IRS-related events
    		IRS-related events1.00
    		Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.90
    		IRS-mediated signalling0.98
    		IGF1R signaling cascade0.90
    		Insulin receptor signalling cascade0.94
    		PI3K Cascade0.84
    		IRS-related events triggered by IGF1R0.93
    		Signaling by Insulin receptor0.74
    4Development IGF-RI signaling
    		Development IGF-RI signaling1.00
    		Signal transduction_AKT signaling0.49
    		Development_IGF-1 receptor signaling0.99
    		Signal transduction AKT signaling0.49
    5mTOR signalling
    		mTOR signalling1.00
    		TOR signaling0.33
    		PKB-mediated events0.96

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/18 EMD Millipore Pathways for RPS6KB1 (see all 18)
        Translation Translation regulation by Alpha-1 adrenergic receptors
    Development Growth hormone signaling via PI3K/AKT and MAPK cascades
    Development Endothelin-1/EDNRA transactivation of EGFR
    Regulation of lipid metabolism Insulin signaling-generic cascades
    Translation Insulin regulation of translation

    5/9 R&D Systems Pathways for RPS6KB1 (see all 9)
        IL-21 Signaling Pathways
    IL-2 Signaling Pathways
    IL-4 Signaling Pathways
    Adipocytokines & Insulin Signaling
    IL-7 Signaling Pathways

    5/25 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RPS6KB1 (see all 25)
        FLT3 Signaling
    UVB-Induced MAPK Signaling
    IL-4 Pathway
    Interferon Pathway
    Glioblastoma Multiforme

    1 Cell Signaling Technology (CST) Pathway for RPS6KB1
        Translational Control

    5/18 GeneGo (Thomson Reuters) Pathways for RPS6KB1 (see all 18)
        Development Endothelin-1/EDNRA transactivation of EGFR
    Development CNTF receptor signaling
    Signal transduction AKT signaling
    Translation Insulin regulation of translation
    Transcription Receptor-mediated HIF regulation

    5/28 BioSystems Pathways for RPS6KB1 (see all 28) 
        AMPK signaling
    TOR signaling
    ErbB signaling pathway
    G13 Signaling Pathway
    IL-2 Signaling Pathway

    5/14        Reactome Pathways for RPS6KB1 (see all 14)
        PI3K Cascade
    IGF1R signaling cascade
    S6K1 signalling
    mTOR signalling
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)


    5/6         Kegg Pathways  (Kegg details for RPS6KB1) (see all 6):
        ErbB signaling pathway
    mTOR signaling pathway
    TGF-beta signaling pathway
    Fc gamma R-mediated phagocytosis
    Insulin signaling pathway


    RPS6KB1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RPS6KB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/103 Interacting proteins for RPS6KB1 (P234431, 2, 3 ENSP000002255774) via UniProtKB, MINT, STRING, and/or I2D (see all 103)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COASYQ130572, 3MINT-51122 MINT-51123 MINT-51062 MINT-51063 I2D: score=4 
    MAPTP106362, 3, ENSP000003408204MINT-74874 MINT-74872 I2D: score=1 STRING: ENSP00000340820
    PDPK1O155302, 3, ENSP000003442204MINT-14377 I2D: score=3 STRING: ENSP00000344220
    CLEC3BP054522, 3, ENSP000002961304MINT-8269989 I2D: score=2 STRING: ENSP00000296130
    DPPA4Q7L1902, 3, ENSP000003353064MINT-8270000 I2D: score=2 STRING: ENSP00000335306
    About this table

    Gene Ontology (GO): 5/45 biological process terms (GO ID links to tree view) (see all 45):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle IMP14673156
    GO:0003009skeletal muscle contraction IEA--
    GO:0006468protein phosphorylation IDA19085255
    GO:0006915apoptotic process IEA--
    GO:0007165signal transduction TAS1922062


    RPS6KB1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RPS6KB1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RPS6KB1 for compounds           About GeneDecksing

    EMD Millipore small molecules for RPS6KB1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for RPS6KB1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PF 4708671S6K1 inhibitor[1255517-76-0]

    2 HMDB Compounds for RPS6KB1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    10/75 Novoseek chemical compound relationships for RPS6KB1 gene (see all 75)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rapamycin 95.5 518 9271419 (6), 17660033 (5), 14871980 (5), 8389370 (5) (see all 99)
    wortmannin 82.5 75 7545671 (3), 9468542 (2), 11446769 (2), 12296652 (2) (see all 50)
    ly294002 82.4 39 12242656 (3), 9367837 (2), 13679036 (1), 16139919 (1) (see all 31)
    phosphatidylinositol 81.9 96 18948408 (4), 12183455 (3), 7961833 (3), 11279232 (3) (see all 56)
    everolimus 74 21 14729632 (4), 20204306 (2), 18332467 (2), 19471857 (1) (see all 8)
    phosphoinositide 70.3 35 8621477 (2), 15816524 (2), 7826337 (2), 11027274 (2) (see all 20)
    threonine 66.3 31 18461003 (3), 12555062 (2), 12713446 (2), 9751223 (2) (see all 23)
    serine 59.5 50 18948408 (3), 20203102 (3), 16914728 (3), 18952604 (2) (see all 29)
    pd 98,059 58.6 12 11279232 (2), 12242656 (1), 11368346 (1), 19474060 (1) (see all 11)
    phosphatidylinositol-3,4,5-trisphosphate 54 1 9768361 (1)

    Search CenterWatch for drugs/clinical trials and news about RPS6KB1 / KS6B1 

    Transcripts
    for RPS6KB1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RPS6KB1 gene (5 alternative transcripts): 
    NM_001272042.1  NM_001272043.1  NM_001272044.1  NM_001272060.1  NM_003161.3  

    Unigene Cluster for RPS6KB1:

    Ribosomal protein S6 kinase, 70kDa, polypeptide 1
    Hs.463642  [show with all ESTs]
    Unigene Representative Sequence: NM_003161
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000472940 ENST00000477179 ENST00000443572 ENST00000489824 ENST00000406116(uc010ddj.2)
    ENST00000225577(uc002ixy.3 uc010wom.2 uc010won.2 uc010woo.2)
    ENST00000592726 ENST00000587622 ENST00000590928 ENST00000475155 ENST00000587061
    ENST00000393021

    miRNA
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    8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate RPS6KB1 (see all 55):
    hsa-miR-579 hsa-miR-100* hsa-miR-429 hsa-miR-605 hsa-miR-128 hsa-miR-218 hsa-miR-507 hsa-miR-3161
    SwitchGear 3'UTR luciferase reporter plasmid: RPS6KB1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPS6KB1 (see all 6)
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    Clone
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    Additional cDNA sequence: 

    AK026730.1 AK091503.1 AK293247.1 AK297147.1 AK300202.1 AK312875.1 BC030763.2 BC036033.1 
    BC053365.1 M60724.1 M60725.1 

    11 DOTS entries:

    DT.316003  DT.95270971  DT.100785618  DT.91858174  DT.121012844  DT.121012842  DT.65285220  DT.91746169 
    DT.92029419  DT.100683971  DT.91864442 

    24/230 AceView cDNA sequences (see all 230):

    BE877872 AA828362 AA425446 AU077265 AA806019 AA362032 BP365397 BQ777439 
    CR604237 AI754381 AI091810 AA768404 AI620614 AI262530 AU103944 BU160729 
    AI263413 AW949378 AI281289 BE049560 AL602438 BM802717 AA830851 AK097658 

    GeneLoc Exon Structure


    Expression
    for RPS6KB1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPS6KB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGAAATGTTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RPS6KB1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryPrimary FolliclePrimary OocyteFemale Gametocytes, Germ Cells
    OvaryPrimordial FolliclePrimary OocyteFemale Gametocytes, Germ Cells
    Reproductive SystemEarly GonadTestis Somatic CellsTestis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RPS6KB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPS6KB1

    SOURCE GeneReport for Unigene cluster: Hs.463642

    UniProtKB/Swiss-Prot: KS6B1_HUMAN, P23443
    Tissue specificity: Widely expressed

        SABiosciences Expression via Pathway-Focused PCR Arrays including RPS6KB1 (see all 8): 
              mTOR Signaling in human mouse rat
              Insulin Resistance in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              Autophagy in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for RPS6KB1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPS6KB1 gene from 8/27 species (see all 27)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RPS6KB11 ribosomal protein S6 kinase, 70kDa, polypeptide 1 88.58(n)
    97.21(a)    		   417637  NM_001030721.1  NP_001025892.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RPS6KB16
    		 --
    		 95(a)
    		 1 ↔ 1
    		 GL343470.1(194051-214694)
    African clawed frog
    (Xenopus laevis)    		 Amphibia rps6kb1-A2 ribosomal protein S6 kinase, 70kDa, polypeptide 1 79.25(n)    AJ131521.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.245282 Danio rerio cDNA clone MGC55713 IMAGE3815976, complete cds less 80.49(n)    BC046888.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta S6k1 , 3 cell growth and/or maintenance protein
    serine/threonine kinase less3
    RPS6-p70-protein kinase1    		 72(a)
    (best of 2)3
    65.94(n)1
    73.22(a)1    		   386541  NM_079217.21  NP_523941.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y47D3A.163
    rsks-11    		 ribosomal protein S6 kinase3
    Protein RSKS-11    		 60(a)
    (best of 3)3
    61.1(n)1
    63.09(a)1    		   III(11316958-11322832)3
    1765541  NM_067046.21  NP_499447.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons S6K21 serine/threonine protein kinase 2 52.28(n)
    47.27(a)    		   820019  NM_111706.3  NP_187484.1 
    rice
    (Oryza sativa)    		 Liliopsida Os03g03340001 hypothetical protein 54.9(n)
    48.75(a)    		   4332748  NM_001056562.1  NP_001050027.1 


    ENSEMBL Gene Tree for RPS6KB1 (if available)
    TreeFam Gene Tree for RPS6KB1 (if available) 

    Paralogs
    for RPS6KB1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPS6KB1 gene
    AKT12  RPS6KA62  SGK32  SGK22  RPS6KA12  AKT32  RPS6KA52  RPS6KA42  
    SGK12  RPS6KB22  RPS6KA22  AKT22  RPS6KA32  
    18/78 SIMAP similar genes for RPS6KB1 using alignment to 8 protein entries:     KS6B1_HUMAN (see all proteins) (see all similar genes):
    RPS6KB2    RPS6KA2    RPS6KA3    AKT3    PRKCE    RPS6KA1
    RPS6KA4    SGK2    PKN2    PRKCI    MARK4    PRKCH
    PRKCQ    PRKACA    RPS6KA6    PRKCB    RPS6KA5    KIN27

    RPS6KB1 for paralogs           About GeneDecksing


    5/6 Pseudogenes.org Pseudogenes for RPS6KB1 (see all 6)
    PGOHUM00000237046 PGOHUM00000237050 PGOHUM00000237051 PGOHUM00000237059 PGOHUM00000237134


    Genomic Variants
    for RPS6KB1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/862 NCBI SNPs in RPS6KB1 are shown (see all 862)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs769203341,2
    		--53342102(+) GCTCAG/AGTAGG 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs2014345541,2
    		C--53342127(+) GCAGCC/TTGGAG 1 -- us2k10--------
    rs39009061,2
    		C,F,H,--53342159(-) GCGCCC/AGGTTA 1 -- us2k1 tfbs317Minor allele frequency- A:0.02NS EA NA WA 1884
    rs573146771,2
    		F,--53342338(+) AAAAGA/CCAAGT 1 -- us2k11Minor allele frequency- C:0.07WA 118
    rs728388921,2
    		C,--53343974(+) AAAAAA/CCCAAA 1 -- int10--------
    rs1132617821,2
    		--53344843(+) AATCAC/TACGGT 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs728388931,2
    		--53344917(+) TTCTGG/TTTTTT 1 -- int10--------
    rs80700871,2
    		C,--53345592(+) tgatcG/Tcggct 1 -- int10--------
    rs80700391,2
    		C,F,A,--53346116(+) gtcttG/Cctcta 1 -- int18Minor allele frequency- C:0.12NA WA EA 368
    rs803168731,2
    		C,F,--53346458(+) GTGTTT/GCAAGA 1 -- int11Minor allele frequency- G:0.05WA 118

    HapMap Linkage Disequilibrium report for RPS6KB1 (57970443 - 58027925 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 7 variations for RPS6KB1
         7 CNVs: 30842 77677 88555 72987 0805 32189 4044
    Human Gene Mutation Database (HGMD): RPS6KB1

    1 SABiosciences Cancer Mutation PCR Assay for RPS6KB1:
    Cosmic IdAA Change
    32843p.G289E
    1 SABiosciences qBiomarker Copy Number PCR Array containing RPS6KB1:
    Kinases & Phosphatases
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPS6KB1
    DNA2.0 Custom Variant and Variant Library Synthesis for RPS6KB1

    Disorders / Diseases
    for RPS6KB1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RPS6KB1 for disorders           About GeneDecksing

    OMIM gene information: 608938    OMIM disorders: --

    20/90 diseases for RPS6KB1 (see all 90):    About MalaCards
    malignant peripheral nerve sheath tumor    breast cancer    diffuse large b-cell lymphoma    non-small cell lung carcinoma
    b-cell lymphomas    anaplastic large cell lymphoma    gastrointestinal stromal tumor    ataxia telangiectasia
    tuberous sclerosis    placental choriocarcinoma    glucocorticoid resistance    insulin resistance
    kidney angiomyolipoma    oral squamous cell carcinoma    muscle hypertrophy    squamous cell carcinoma
    embryonal rhabdomyosarcoma    adult t-cell leukemia    rheumatoid arthritis    chronic lymphocytic leukemia

    1 disease from the University of Copenhagen DISEASES database for RPS6KB1:
    Cancer

    10/44 Novoseek disease relationships for RPS6KB1 gene (see all 44)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tuberous sclerosis 75.5 9 16914728 (2), 15249583 (1), 12384518 (1), 18094073 (1) (see all 6)
    tumors 44.3 52 15112576 (3), 15627062 (3), 12733712 (2), 16489002 (2) (see all 30)
    cancer 42.9 28 12433206 (4), 17624310 (2), 17452018 (1), 12733712 (1) (see all 16)
    glioblastoma 37.2 1 20423992 (1)
    rhabdomyosarcoma 36.4 5 12000755 (1), 15735038 (1), 17585318 (1), 8909805 (1)
    retinoblastoma 33.9 1 11426655 (1)
    insulin resistance 33.2 24 16753575 (3), 18948408 (3), 18252807 (2), 18952604 (1) (see all 11)
    hamartoma 28.5 1 16914728 (1)
    hypertrophy 26.6 14 9242178 (4), 15963500 (2), 18160324 (2), 16717578 (1) (see all 7)
    ataxia telangiectasia 24.2 1 10971657 (1)

    Human Genome Epidemiology (HuGE) Navigator: RPS6KB1 (11 documents)

    Export disorders for RPS6KB1 gene to outside databases

    Publications
    for RPS6KB1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPS6KB1 gene, integrated from 9 sources (see all 773):
    (articles sorted by number of sources associating them with RPS6KB1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini. (PubMed id 1922062)1, 2, 3 Grove J.... Woodgett J.R. (1991)
    2. S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2. (PubMed id 18952604)1, 2, 9 Zhang J....Ye J. (2008)
    3. mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. (PubMed id 16286006)1, 2, 9 Holz M.K.... Blenis J. (2005)
    4. mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E. (PubMed id 14673156)1, 2, 9 Fingar D.C....Blenis J. (2004)
    5. SKAR is a specific target of S6 kinase 1 in cell growth control. (PubMed id 15341740)1, 2, 9 Richardson C.J....Blenis J. (2004)
    6. Phosphorylation and activation of p70s6k by PDK1. (PubMed id 9445476)1, 2, 9 Pullen N....Thomas G. (1998)
    7. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. (PubMed id 12150926)1, 2, 9 Hara K.... Yonezawa K. (2002)
    8. Structural basis of human p70 ribosomal S6 kinase-1 r egulation by activation loop phosphorylation. (PubMed id 19864428)1, 2, 9 Sunami T....Sharma S. (2010)
    9. Regulation and localization of ribosomal protein S6 kinase 1 isoforms. (PubMed id 19085255)1, 2, 9 Kim D....Meric-Bernstam F. (2009)
    10. Functions and regulation of the 70kDa ribosomal S6 ki nases. (PubMed id 20932932)1, 2 Fenton T.R. and Gout I.T. (2011)

    External Searches for RPS6KB1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RPS6KB1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6198 HGNC: 10436 AceView: RPS6KB1 Ensembl:ENSG00000108443 euGenes: HUgn6198
    ECgene: RPS6KB1 Kegg: 6198 H-InvDB: RPS6KB1

    Other Databases showing RPS6KB1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RPS6KB1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPS6KB1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RPS6KB1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for RPS6KB1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RPS6KB1 gene:
    Search GeneIP for patents involving RPS6KB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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