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Aliases for RPS6KA6 Gene

Aliases for RPS6KA6 Gene

  • Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 6 2 3
  • RSK4 3 4 6
  • 90 KDa Ribosomal Protein S6 Kinase 6 3 4
  • Ribosomal S6 Kinase 4 3 4
  • S6K-Alpha-6 3 4
  • EC 2.7.11.1 4 63
  • P90-RSK 6 3 4
  • PP90RSK4 3 4
  • P90RSK6 3 4
  • RSK-4 3 4
  • Ribosomal Protein S6 Kinase, 90kD, Polypeptide 6 2
  • Ribosomal Protein S6 Kinase Alpha-6 3
  • S6K-Alpha 6 3
  • EC 2.7.11 63

External Ids for RPS6KA6 Gene

Previous GeneCards Identifiers for RPS6KA6 Gene

  • GC0XM078698
  • GC0XM080395
  • GC0XM081354
  • GC0XM082090
  • GC0XM083125
  • GC0XM083318
  • GC0XM076885

Summaries for RPS6KA6 Gene

Entrez Gene Summary for RPS6KA6 Gene

  • This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. [provided by RefSeq, Jan 2010]

GeneCards Summary for RPS6KA6 Gene

RPS6KA6 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 6) is a Protein Coding gene. Diseases associated with RPS6KA6 include x-linked nonsyndromic deafness and coffin-lowry syndrome. Among its related pathways are MAPK signaling pathway and L1CAM interactions. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is MKNK2.

UniProtKB/Swiss-Prot for RPS6KA6 Gene

  • Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis.

Tocris Summary for RPS6KA6 Gene

  • p90 ribosomal S6 kinases (RSKs) are a family of protein serine/threonine kinases that regulate diverse cellular processes such as cell growth, motility, survival and proliferation. There are four isoforms of this enzyme; RSK1-4, which are directly activated by ERK1/2 in response to growth factors, many polypeptide hormones, neurotransmitters and chemokines. p90 RSKs phosphorylate numerous cytosolic and nuclear targets and act as downstream effectors of the ERK/MAPK signaling cascade. They are expressed ubiquitously in human tissues and exist in multiple subcellular compartments. Abberant activation of p90 RSKs has been linked to many human diseases, including breast and prostate cancers.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS6KA6 Gene

Genomics for RPS6KA6 Gene

Regulatory Elements for RPS6KA6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RPS6KA6 Gene

Start:
84,058,346 bp from pter
End:
84,187,935 bp from pter
Size:
129,590 bases
Orientation:
Minus strand

Genomic View for RPS6KA6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPS6KA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS6KA6 Gene

Proteins for RPS6KA6 Gene

  • Protein details for RPS6KA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK32-KS6A6_HUMAN
    Recommended name:
    Ribosomal protein S6 kinase alpha-6
    Protein Accession:
    Q9UK32
    Secondary Accessions:
    • B2R854
    • B7ZL90
    • Q6FHX2
    • Q8WX28
    • Q9H4S6

    Protein attributes for RPS6KA6 Gene

    Size:
    745 amino acids
    Molecular mass:
    83872 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Forms a complex with MAPK3/ERK1 but not with MAPK9 or MAPK14 in serum-starved cells

    Alternative splice isoforms for RPS6KA6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPS6KA6 Gene

Proteomics data for RPS6KA6 Gene at MOPED

Post-translational modifications for RPS6KA6 Gene

  • Phosphorylated at Ser-232, Ser-372, and Ser-389 in serum-starved cells.
  • Ubiquitination at Lys86 and Lys570
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS6KA6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for RPS6KA6 Gene

Suggested Antigen Peptide Sequences for RPS6KA6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UK32

UniProtKB/Swiss-Prot:

KS6A6_HUMAN :
  • Q9UK32
Domain:
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 2 protein kinase domains.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
genes like me logo Genes that share domains with RPS6KA6: view

Function for RPS6KA6 Gene

Molecular function for RPS6KA6 Gene

GENATLAS Biochemistry: ribosomal protein S6 kinase 4,abundantly expressed in brain and kidney,involved in neuronal development,member of a family of growth factor related serine threonine kinases,deleted in patients with complex X-linked mental retardation
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Constitutively activated by phosphorylation at Ser-232, Ser-372, and Ser-389 in serum-starved cells. Does not require growth factor stimulation for significant kinase activity.
UniProtKB/Swiss-Prot Function: Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis.

Enzyme Numbers (IUBMB) for RPS6KA6 Gene

Gene Ontology (GO) - Molecular Function for RPS6KA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0004672 protein kinase activity TAS 10644430
GO:0004674 protein serine/threonine kinase activity --
GO:0004711 ribosomal protein S6 kinase activity IBA --
GO:0004713 protein tyrosine kinase activity --
genes like me logo Genes that share ontologies with RPS6KA6: view

Phenotypes for RPS6KA6 Gene

genes like me logo Genes that share phenotypes with RPS6KA6: view

Animal Model Products

CRISPR Products

miRNA for RPS6KA6 Gene

miRTarBase miRNAs that target RPS6KA6

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPS6KA6

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for RPS6KA6 Gene

Localization for RPS6KA6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS6KA6 Gene

Cytoplasm, cytosol. Nucleus. Note=Predominantly cytosolic.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS6KA6 Gene COMPARTMENTS Subcellular localization image for RPS6KA6 gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 3

Gene Ontology (GO) - Cellular Components for RPS6KA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005739 mitochondrion IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RPS6KA6: view

Pathways for RPS6KA6 Gene

genes like me logo Genes that share pathways with RPS6KA6: view

Gene Ontology (GO) - Biological Process for RPS6KA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IBA --
GO:0006468 protein phosphorylation IBA --
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IMP 15042092
GO:0007165 signal transduction TAS 10644430
GO:0007268 synaptic transmission TAS --
genes like me logo Genes that share ontologies with RPS6KA6: view

Compounds for RPS6KA6 Gene

(3) Tocris Compounds for RPS6KA6 Gene

Compound Action Cas Number
BRD 7389 p90 ribosomal S6 kinase inhibitor [376382-11-5]
PF 4708671 S6K1 inhibitor [1255517-76-0]
SL 0101-1 Selective p90 ribosomal S6 kinase (RSK) inhibitor [77307-50-7]

(3) HMDB Compounds for RPS6KA6 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4
genes like me logo Genes that share compounds with RPS6KA6: view

Transcripts for RPS6KA6 Gene

mRNA/cDNA for RPS6KA6 Gene

Unigene Clusters for RPS6KA6 Gene

Ribosomal protein S6 kinase, 90kDa, polypeptide 6:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPS6KA6

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RPS6KA6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS6KA6 Gene

No ASD Table

Relevant External Links for RPS6KA6 Gene

GeneLoc Exon Structure for
RPS6KA6
ECgene alternative splicing isoforms for
RPS6KA6

Expression for RPS6KA6 Gene

mRNA expression in normal human tissues for RPS6KA6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS6KA6 Gene

SOURCE GeneReport for Unigene cluster for RPS6KA6 Gene Hs.234478

genes like me logo Genes that share expressions with RPS6KA6: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS6KA6 Gene

Orthologs for RPS6KA6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS6KA6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPS6KA6 35
  • 98.17 (n)
  • 97.66 (a)
RPS6KA6 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RPS6KA6 35
  • 94.18 (n)
  • 96.37 (a)
RPS6KA6 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPS6KA6 35
  • 93.19 (n)
  • 94.89 (a)
RPS6KA6 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rps6ka6 35
  • 87.87 (n)
  • 88.54 (a)
Rps6ka6 16
Rps6ka6 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RPS6KA6 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPS6KA6 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rps6ka6 35
  • 88.27 (n)
  • 88.81 (a)
chicken
(Gallus gallus)
Aves RPS6KA6 35
  • 82.57 (n)
  • 87.94 (a)
RPS6KA6 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 84 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rps6ka6 35
  • 78.42 (n)
  • 86.83 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
rps6kal 35
  • 73.72 (n)
  • 84.8 (a)
fruit fly
(Drosophila melanogaster)
Insecta S6kII 36
  • 46 (a)
OneToMany
Pk17E 37
  • 40 (a)
S6kII 37
  • 55 (a)
worm
(Caenorhabditis elegans)
Secernentea rskn-1 36
  • 53 (a)
OneToMany
F28C10.3 37
  • 35 (a)
T01H8.1b 37
  • 60 (a)
R04A9.5 37
  • 43 (a)
corn
(Zea mays)
Liliopsida Zm.12589 35
rice
(Oryza sativa)
Liliopsida Os.13521 35
wheat
(Triticum aestivum)
Liliopsida Ta.9084 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 67 (a)
OneToMany
Species with no ortholog for RPS6KA6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPS6KA6 Gene

ENSEMBL:
Gene Tree for RPS6KA6 (if available)
TreeFam:
Gene Tree for RPS6KA6 (if available)

Paralogs for RPS6KA6 Gene

genes like me logo Genes that share paralogs with RPS6KA6: view

Variants for RPS6KA6 Gene

Sequence variations from dbSNP and Humsavar for RPS6KA6 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1332726 -- 84,061,446(+) AAACA(A/C)TGTTT utr-variant-3-prime
rs1389465 -- 84,121,641(+) cttgc(A/G)aaggt intron-variant
rs1389466 -- 84,100,751(-) TACAA(C/T)ATATT intron-variant
rs1539517 -- 84,148,170(+) TTCTA(C/G)TCATT intron-variant
rs1544221 -- 84,183,684(+) TCTTA(C/T)ATTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPS6KA6 Gene

Variant ID Type Subtype PubMed ID
nsv483019 CNV Gain 15286789
nsv9958 CNV Loss 18304495
nsv513613 CNV Insertion 21212237

Relevant External Links for RPS6KA6 Gene

HapMap Linkage Disequilibrium report
RPS6KA6
Locus Specific Mutation Databases (LSDB)
RPS6KA6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS6KA6 Gene

Disorders for RPS6KA6 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for RPS6KA6 Gene including...

Search for RPS6KA6 Gene in MalaCards »

(3) University of Copenhagen DISEASES for RPS6KA6 Gene

Relevant External Links for RPS6KA6

Genetic Association Database (GAD)
RPS6KA6
Human Genome Epidemiology (HuGE) Navigator
RPS6KA6
genes like me logo Genes that share disorders with RPS6KA6: view

No data available for UniProtKB/Swiss-Prot for RPS6KA6 Gene

Publications for RPS6KA6 Gene

  1. A novel ribosomal S6-kinase (RSK4; RPS6KA6) is commonly deleted in patients with complex X-linked mental retardation. (PMID: 10644430) Yntema H.G. … van Bokhoven H. (Genomics 1999) 2 3 4 23
  2. Functional characterization of human RSK4, a new 90-kDa ribosomal S6 kinase, reveals constitutive activation in most cell types. (PMID: 15632195) Duemmler B.A. … Froedin M. (J. Biol. Chem. 2005) 3 4 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. A large-scale RNAi screen in human cells identifies new components of the p53 pathway. (PMID: 15042092) Berns K. … Bernards R. (Nature 2004) 3 4
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4

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