Aliases for RPS6KA6 Gene
External Ids for RPS6KA6 Gene
Previous GeneCards Identifiers for RPS6KA6 Gene
This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. [provided by RefSeq, Jan 2010]
GeneCards Summary for RPS6KA6 Gene
RPS6KA6 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 6) is a Protein Coding gene. Diseases associated with RPS6KA6 include x-linked nonsyndromic deafness and coffin-lowry syndrome. Among its related pathways are MAPK signaling pathway and L1CAM interactions. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is MKNK2.
UniProtKB/Swiss-Prot for RPS6KA6 Gene
Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis.
p90 ribosomal S6 kinases (RSKs) are a family of protein serine/threonine kinases that regulate diverse cellular processes such as cell growth, motility, survival and proliferation. There are four isoforms of this enzyme; RSK1-4, which are directly activated by ERK1/2 in response to growth factors, many polypeptide hormones, neurotransmitters and chemokines. p90 RSKs phosphorylate numerous cytosolic and nuclear targets and act as downstream effectors of the ERK/MAPK signaling cascade. They are expressed ubiquitously in human tissues and exist in multiple subcellular compartments. Abberant activation of p90 RSKs has been linked to many human diseases, including breast and prostate cancers.