Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPS6KA6 Gene

protein-coding   GIFtS: 68
GCID: GC0XM083318

Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 6

(Previous names: ribosomal protein S6 kinase, 90kD, polypeptide 6)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 61 2     EC 2.7.11.13 8
RSK42 3 5     Ribosomal Protein S6 Kinase, 90kD, Polypeptide 61
Ribosomal S6 Kinase 42 3     PP90RSK42
90 KDa Ribosomal Protein S6 Kinase 62 3     Ribosomal Protein S6 Kinase Alpha-62
RSK-42 3     S6K-Alpha 62
S6K-alpha-62 3     pp90RSK43
P90-RSK 62 3     EC 2.7.118
p90RSK62 3     

External Ids:    HGNC: 104351   Entrez Gene: 273302   Ensembl: ENSG000000721337   OMIM: 3003035   UniProtKB: Q9UK323   

Export aliases for RPS6KA6 gene to outside databases

Previous GC identifers: GC0XM078698 GC0XM080395 GC0XM081354 GC0XM082090 GC0XM083125 GC0XM076885


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RPS6KA6 Gene:
This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by
growth factors. The encoded protein may be distinct from other members of this family, however, as studies
suggest it is not growth factor dependent and may not participate in the same signaling pathways. (provided by
RefSeq, Jan 2010)

GeneCards Summary for RPS6KA6 Gene: 
RPS6KA6 (ribosomal protein S6 kinase, 90kDa, polypeptide 6) is a protein-coding gene. Diseases associated with RPS6KA6 include x-linked nonsyndromic deafness, and coffin-lowry syndrome, and among its related super-pathways are Axon guidance and Activation of NMDA receptor upon glutamate binding and postsynaptic events. GO annotations related to this gene include protein serine/threonine kinase activity and magnesium ion binding. An important paralog of this gene is AKT1.

UniProtKB/Swiss-Prot: KS6A6_HUMAN, Q9UK32
Function: Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase
activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role
during embryogenesis

summary for RPS6KA6 Gene:
p90 ribosomal S6 kinases (RSKs) are a family of protein serine/threonine kinases that regulate diverse
cellular processes such as cell growth, motility, survival and proliferation. There are four isoforms of
this enzyme; RSK1-4, which are directly activated by ERK1/2 in response to growth factors, many polypeptide
hormones, neurotransmitters and chemokines. p90 RSKs phosphorylate numerous cytosolic and nuclear targets
and act as downstream effectors of the ERK/MAPK signaling cascade. They are expressed ubiquitously in human
tissues and exist in multiple subcellular compartments. Abberant activation of p90 RSKs has been linked to
many human diseases, including breast and prostate cancers.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_011651.17  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPS6KA6 gene promoter:
         AML1a   Brachyury   CUTL1   IRF-1   YY1   S8   SRY   E2F   E2F-1   HFH-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPS6KA6 promoter sequence
   Search SABiosciences Chromatin IP Primers for RPS6KA6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS6KA6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq21   Ensembl cytogenetic band:  Xq21.1   HGNC cytogenetic band: Xq21.1

RPS6KA6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS6KA6 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM083318:  view genomic region     (about GC identifiers)

Start:
83,313,354 bp from pter      End:
83,442,943 bp from pter
Size:
129,590 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KS6A6_HUMAN, Q9UK32 (See protein sequence)
Recommended Name: Ribosomal protein S6 kinase alpha-6  
Size: 745 amino acids; 83872 Da
Cofactor: Magnesium (By similarity)
Subunit: Forms a complex with MAPK3/ERK1 but not with MAPK9 or MAPK14 in serum-starved cells
Subcellular location: Cytoplasm, cytosol. Nucleus. Note=Predominantly cytosolic
Secondary accessions: B2R854 Q6FHX2 Q8WX28 Q9H4S6

Explore the universe of human proteins at neXtProt for RPS6KA6: NX_Q9UK32

Explore proteomics data for RPS6KA6 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated at Ser-232, Ser-372, and Ser-389 in serum-starved cells
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UK32

  • 4/32 DME Specific Peptides for RPS6KA6 (Q9UK32) (see all 32)
     VVHRDLK  CDIWSLG  KLTDFGL  LYAMKVL 

    RPS6KA6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RPS6KA6 Protein Expression
    REFSEQ proteins: NP_055311.1  
    ENSEMBL proteins: 
     ENSP00000262752   ENSP00000440830  
    Reactome Protein details: Q9UK32
    Human Recombinant Protein Products for RPS6KA6: 
    EMD Millipore Purified and/or Recombinant RPS6KA6 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RPS6KA6
    OriGene Protein Over-expression Lysate for RPS6KA6
    OriGene MassSpec for RPS6KA6 
    OriGene Custom Protein Services for RPS6KA6
    GenScript Custom Purified and Recombinant Proteins Services for RPS6KA6
    Novus Biologicals RPS6KA6 Protein
    Novus Biologicals RPS6KA6 Lysate
    Sino Biological Recombinant Protein for RPS6KA6
    Sino Biological Cell Lysate for RPS6KA6 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RPS6KA6 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--

    RPS6KA6 for ontologies           About GeneDecksing



    RPS6KA6 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of RPS6KA6
    R&D Systems Antibodies for RPS6KA6 (RSK4)
    OriGene Antibodies for RPS6KA6
    OriGene Custom Antibody Services for RPS6KA6
    GenScript Custom Superior Antibodies Services for RPS6KA6
    Novus Biologicals RPS6KA6 Antibodies
    Abcam antibodies for RPS6KA6
    Cloud-Clone Corp. Antibodies for RPS6KA6 
    ThermoFisher Antibodies for RPS6KA6
    LSBio Antibodies in human, mouse, rat for RPS6KA6 

    Assay Products for RPS6KA6: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RPS6KA6
    R&D Systems ELISAs for RPS6KA6 (RSK4)
    GenScript Custom Assay Services for RPS6KA6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RPS6KA6 
    Cloud-Clone Corp. CLIAs for RPS6KA6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: ribosomal protein S6 kinase, 90kDa, polypeptide 6 
    RSK subfamily
    Other AGC kinases

    5/8 InterPro protein domains (see all 8):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR000961 AGC-kinase_C
     IPR011009 Kinase-like_dom
     IPR017892 Pkinase_C

    Graphical View of Domain Structure for InterPro Entry Q9UK32

    ProtoNet protein and cluster: Q9UK32

    1 Blocks protein domain: IPB000961 Protein kinase C-terminal domain

    UniProtKB/Swiss-Prot: KS6A6_HUMAN, Q9UK32
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 2 protein kinase domains


    RPS6KA6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KS6A6_HUMAN, Q9UK32
    Function: Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase
    activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role
    during embryogenesis
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Constitutively activated by phosphorylation at Ser-232, Ser-372, and Ser-389 in serum-starved
    cells. Does not require growth factor stimulation for significant kinase activity

         Genatlas biochemistry entry for RPS6KA6:
    ribosomal protein S6 kinase 4,abundantly expressed in brain and kidney,involved in neuronal development,member of
    a family of growth factor related serine threonine kinases,deleted in patients with complex X-linked mental
    retardation

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0004672protein kinase activity TAS10644430
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IEA--
         
    RPS6KA6 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RPS6KA6:
     Prevent p53-dependent growth a 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rps6ka6):
     cardiovascular system  craniofacial  embryogenesis 

    RPS6KA6 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RPS6KA6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RPS6KA6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RPS6KA6 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RPS6KA6 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPS6KA6
    8/101 QIAGEN miScript miRNA Assays for microRNAs that regulate RPS6KA6 (see all 101):
    hsa-miR-411* hsa-miR-140-5p hsa-miR-548j hsa-miR-520e hsa-miR-520f hsa-miR-15a hsa-miR-106a hsa-miR-199a-3p
    SwitchGear 3'UTR luciferase reporter plasmidRPS6KA6 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RPS6KA6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS6KA6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RPS6KA6
    Sirion Biotech Customized adenovirus for overexpression of RPS6KA6

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RPS6KA6 (see all 11)
    OriGene ORF clones in mouse, rat for RPS6KA6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RPS6KA6 (NM_014496)
    Sino Biological Human cDNA Clone for RPS6KA6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPS6KA6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS6KA6
    Sirion Biotech Customized lentivirus for stable overexpression of RPS6KA6 
                         Customized lentivirus expression plasmids for stable overexpression of RPS6KA6 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RPS6KA6
    Search LifeMap BioReagents cell lines for RPS6KA6
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS6KA6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RPS6KA6 About   (see all 24)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Axon guidance
    Axon guidance0.69
    Recycling pathway of L10.38
    Developmental Biology0.69
    Signal transduction by L10.32
    L1CAM interactions0.39
    2Post NMDA receptor activation events
    Post NMDA receptor activation events0.89
    CREB phosphorylation through the activation of Ras0.82
    Activation of NMDA receptor upon glutamate binding and postsynaptic events0.89
    3Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    ERK5 Signaling0.61
    Cellular Apoptosis Pathway0.85
    4Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.67
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72
    5mTOR Pathway
    mTOR Pathway0.38
    Insulin Pathway0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RPS6KA6 (see all 15)
        FLT3 Signaling
    MAPK Signaling
    Mitochondrial Apoptosis
    CNTF Signaling
    GDNF-Family Ligands and Receptor Interactions

    5 Tocris Bioscience Pathways for RPS6KA6
        Insulin Pathway
    Apoptosis Pathway
    NF-kappaB Pathway
    MAPK Pathway
    mTOR Pathway

    2 BioSystems Pathways for RPS6KA6
        Insulin Signaling
    Cytoplasmic Ribosomal Proteins


    5/12        Reactome Pathways for RPS6KA6 (see all 12)
        L1CAM interactions
    Developmental Biology
    Transmission across Chemical Synapses
    Post NMDA receptor activation events
    Neuronal System


    5/6         Kegg Pathways  (Kegg details for RPS6KA6) (see all 6):
        MAPK signaling pathway
    Oocyte meiosis
    mTOR signaling pathway
    Long-term potentiation
    Neurotrophin signaling pathway


    RPS6KA6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPS6KA6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/53 Interacting proteins for RPS6KA6 (Q9UK322, 3 ENSP000002627524) via UniProtKB, MINT, STRING, and/or I2D (see all 53)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADIRFQ158472, 3MINT-8269736 I2D: score=2 
    C14orf1Q9UKR52, 3MINT-8269747 I2D: score=2 
    CEBPZQ037012, 3MINT-8269769 I2D: score=2 
    CENPBP071992, 3MINT-8269780 I2D: score=2 
    CLEC3BP054522, 3MINT-8269791 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IMP15042092
    GO:0007165signal transduction TAS10644430
    GO:0007243intracellular protein kinase cascade IEA--
    GO:0007268synaptic transmission TAS--

    RPS6KA6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for RPS6KA6 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BRD 7389p90 ribosomal S6 kinase inhibitor[376382-11-5]
    PF 4708671S6K1 inhibitor[1255517-76-0]
    SL 0101-1Selective p90 ribosomal S6 kinase (RSK) inhibitor[77307-50-7]

    3 HMDB Compounds for RPS6KA6    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    Search CenterWatch for drugs/clinical trials and news about RPS6KA6 / KS6A6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RPS6KA6 gene: 
    NM_014496.4  

    Unigene Cluster for RPS6KA6:

    Ribosomal protein S6 kinase, 90kDa, polypeptide 6
    Hs.234478  [show with all ESTs]
    Unigene Representative Sequence: NM_014496
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262752(uc004eej.2 uc011mqt.2 uc011mqu.2) ENST00000495332
    ENST00000460730 ENST00000543399(uc010nmo.1)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPS6KA6
    8/101 QIAGEN miScript miRNA Assays for microRNAs that regulate RPS6KA6 (see all 101):
    hsa-miR-411* hsa-miR-140-5p hsa-miR-548j hsa-miR-520e hsa-miR-520f hsa-miR-15a hsa-miR-106a hsa-miR-199a-3p
    SwitchGear 3'UTR luciferase reporter plasmidRPS6KA6 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RPS6KA6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS6KA6
    Clone
    Products:
         
    OriGene clones in human, mouse for RPS6KA6 (see all 11)
    OriGene ORF clones in mouse, rat for RPS6KA6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RPS6KA6 (NM_014496)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPS6KA6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS6KA6
    Sirion Biotech Customized lentivirus for stable overexpression of RPS6KA6 
                         Customized lentivirus expression plasmids for stable overexpression of RPS6KA6 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for RPS6KA6
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RPS6KA6
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS6KA6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS6KA6

    Additional mRNA sequence: 

    AF184965.1 AK023104.1 AK026301.1 AK310346.1 AK313240.1 BC143647.1 BC143648.1 CR536566.1 

    4 DOTS entries:

    DT.40204461  DT.40112044  DT.95185890  DT.103574 

    10 AceView cDNA sequences:

    BM714450 AA626690 BU739434 AF184965 BX117884 CD359575 CR536566 NM_014496 
    H82896 H82897 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPS6KA6 expression in normal human tissues (normalized intensities)      RPS6KA6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RPS6KA6 Expression
    About this image


    RPS6KA6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Presumptive Podocytes Podocyte Layer
             Metanephros
     
     Intermediate Mesoderm (Gastrulation Derivatives)
             Mesonephros
     
     Blood (Cardiovascular System)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
     
     Brain (Nervous System)
             Adult Oligodendrocyte Precursor Cells Lateral Ventricle
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac

    See RPS6KA6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPS6KA6

    SOURCE GeneReport for Unigene cluster: Hs.234478
        SABiosciences Custom PCR Arrays for RPS6KA6
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for RPS6KA6
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RPS6KA6
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS6KA6
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS6KA6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS6KA6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPS6KA6 gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rps6ka61 , 5 ribosomal protein S6 kinase polypeptide 61, 5 87.87(n)1
    88.54(a)1
      X (48.20 cM)5
    670711  NM_025949.21  NP_080225.21 
     1113881925 
    chicken
    (Gallus gallus)
    Aves RPS6KA61 ribosomal protein S6 kinase, 90kDa, polypeptide 6 82.41(n)
    87.55(a)
      422273  XM_420257.2  XP_420257.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    RPS6KA66
    ribosomal protein S6 kinase, 90kDa, polypeptide 6
    83(a)
    80(a)
    possible ortholog
    1 ↔ 1
    AAWZ02037556(100-14922)
    GL343202.1(593749-632837)
    zebrafish
    (Danio rerio)
    Actinopterygii BC045478.12   -- 75.79(n)   337670  BC045478.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta S6kII3 protein amino acid phosphorylation
    protein serine/threonine more
    55(a)
    (best of 2)
      20B1   --
    worm
    (Caenorhabditis elegans)
    Secernentea T01H8.1b3 Protein kinase C terminal domain 60(a)
    (best of 3)
      I(8582453-8585937)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SCH96
    Protein kinase involved in transcriptional activat...
    21(a)
    1 → many
    VIII(509363-511837)
    rice
    (Oryza sativa)
    Liliopsida Os.135212 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 76.06(n)    AK072649.1 


    ENSEMBL Gene Tree for RPS6KA6 (if available)
    TreeFam Gene Tree for RPS6KA6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPS6KA6 gene
    AKT12  RPS6KB12  SGK32  C8orf44-SGK32  SGK22  RPS6KA12  RPS6KA52  AKT32  
    RPS6KA42  SGK12  RPS6KB22  RPS6KA22  RPS6KA32  AKT22  
    18/67 SIMAP similar genes for RPS6KA6 using alignment to 2 protein entries:     KS6A6_HUMAN (see all proteins) (see all similar genes):
    RPS6KA3    RPS6KA2    RPS6KA1    KIN27    PRKACA    RPS6KB2
    SGK2    DKFZp564L2416    PRKACG    PRKY    PRKACB    AKT3
    SGK1    RPS6KB1    CAMK1D    MARK4    AKT1    SGK494

    RPS6KA6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1699 SNPs in RPS6KA6 are shown (see all 1699)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0406384
    A lung adenocarcinoma sample4--see VAR_0406382 S T mis40--------
    VAR_0406374
    A lung large cell carcinoma sample4--see VAR_0406372 Y C mis40--------
    rs2001028901,2
    C--83285982(+) AAATT-/TCTGTGT 1 -- ds50010--------
    rs1844987921,2
    --83286020(+) CGGCAC/TACACG 1 -- ds50010--------
    rs66228941,2
    C,F,H--83286079(+) AAAAAA/CTGTTG 1 -- ds50014Minor allele frequency- C:0.12NS EA 420
    rs66228951,2
    C,F,H--83286131(+) AAAAGG/ATTGTC 1 -- ds50014Minor allele frequency- A:0.12NS EA 414
    rs1893248821,2
    --83286185(+) TAAAAA/CTACTG 1 -- ds50010--------
    rs2012680781,2
    C--83286243(+) TAGAA-/GAGT  
            
    AAGTT
    1 -- ds50010--------
    rs1436705361,2
    C--83286324(+) CACCTC/GGCCCC 1 -- ds50010--------
    rs1120299001,2
    C,F--83286346(+) TATCAC/TTGCCA 1 -- ds50011Minor allele frequency- T:0.00CSA 1

    HapMap Linkage Disequilibrium report for RPS6KA6 (83313354 - 83442943 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RPS6KA6:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv513613CNV Insertion21212237
    nsv9958CNV Loss18304495
    nsv483019CNV Gain15286789


    Locus Specific Mutation Databases (LSDB): RPS6KA6
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RPS6KA6
    DNA2.0 Custom Variant and Variant Library Synthesis for RPS6KA6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300303    OMIM disorders: --

    14 diseases for RPS6KA6:    About MalaCards
    x-linked nonsyndromic deafness    coffin-lowry syndrome    choroideremia    nonsyndromic deafness
    prostate cancer    autism spectrum disorder    prostatitis    choroiditis
    mental retardation    diabetes mellitus    melanoma    breast cancer
    endotheliitis    neuronitis

    3 diseases from the University of Copenhagen DISEASES database for RPS6KA6:
    X-linked nonsyndromic deafness     Coffin-Lowry syndrome     Choroideremia

    RPS6KA6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RPS6KA6
    Human Genome Epidemiology (HuGE) Navigator: RPS6KA6 (2 documents)

    Export disorders for RPS6KA6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPS6KA6 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with RPS6KA6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel ribosomal S6-kinase (RSK4; RPS6KA6) is commonly deleted in patients with complex X-linked mental retardation. (PubMed id 10644430)1, 2, 3, 9 Yntema H.G.... van Bokhoven H. (1999)
    2. Functional characterization of human RSK4, a new 90-kDa ribosomal S6 kinase, reveals constitutive activation in most cell types. (PubMed id 15632195)1, 2, 9 Dummler B.A....Frodin M. (2005)
    3. X chromosomal variation is associated with slow progr ession to AIDS in HIV-1-infected women. (PubMed id 19679225)1, 4 Siddiqui R.A....Platzer M. (2009)
    4. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    5. A large-scale RNAi screen in human cells identifies new components of the p53 pathway. (PubMed id 15042092)1, 2 Berns K....Bernards R. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. RSK3/4 mediate resistance to PI3K pathway inhibitors i n breast cancer. (PubMed id 23635776)1 Serra V....Baselga J. (2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. The possible role of ribosomal protein S6 kinase 4 in the senescence of endothelial progenitor cells in diabetes mellitus. (PubMed id 22297070)1 Yin Z....Wang Z. (2012)
    10. Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27330 HGNC: 10435 AceView: RPS6KA6 Ensembl:ENSG00000072133 euGenes: HUgn27330
    ECgene: RPS6KA6 Kegg: 27330 H-InvDB: RPS6KA6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPS6KA6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RPS6KA6 gene:
    Search GeneIP for patents involving RPS6KA6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of RPS6KA6
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore Purified and/or Recombinant RPS6KA6 Protein
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for RPS6KA6 (RSK4)   Browse Cell Culture Products  
     ELISAs for RPS6KA6 (RSK4)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RPS6KA6   OriGene RNAi products in human, mouse, rat for RPS6KA6  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for RPS6KA6  
     OriGene MassSpec something-or-other for RPS6KA6   OriGene clones in human, mouse for RPS6KA6  
     OriGene qSTAR qPCR primer pairs in human, mouse for RPS6KA6   OriGene Purified Protein for RPS6KA6  
     OriGene ORF clones in mouse, rat for RPS6KA6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RPS6KA6   OriGene Custom Protein Services for RPS6KA6  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RPS6KA6
     QIAGEN SeqTarget long-range PCR primers for resequencing RPS6KA6
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS6KA6
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS6KA6
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS6KA6
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS6KA6
     GenScript Custom Purified and Recombinant Proteins Services for RPS6KA6 GenScript cDNA clones with any tag delivered in your preferred vector for RPS6KA6
     GenScript Custom Assay Services for RPS6KA6 GenScript Custom Superior Antibodies Services for RPS6KA6
     GenScript Custom overexpressing Cell Line Services for RPS6KA6 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RPS6KA6 promoter
     Search Chromatin IP Primers for RPS6KA6
     RT2 qPCR Primer Assay in human, mouse, rat RPS6KA6
     Search GNC Networks for RPS6KA6
     SABiosciences PCR Arrays including human, mouse, rat RPS6KA6
     Tocris compounds for RPS6KA6
     Proteins and Antibodies for RPS6KA6
     Cell Lysates for RPS6KA6
     cDNA Clones for RPS6KA6
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RPS6KA6 antibodies
     RPS6KA6 proteins
     RPS6KA6 lysates
     Antibodies for RPS6KA6
     See all of Abcam's Antibodies, Kits and Proteins for RPS6KA6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for RPS6KA6
     Antibodies for RPS6KA6
     ELISAs for RPS6KA6
     CLIAs for RPS6KA6
     Search LifeMap BioReagents cell lines for RPS6KA6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS6KA6
     SwitchGear 3'UTR luciferase reporter plasmids for RPS6KA6
     SwitchGear Promoter luciferase reporter plasmids for RPS6KA6
     ThermoFisher Antibodies for RPS6KA6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS6KA6
     inGenious Targeting Laboratory - Custom generated mouse model solutions for RPS6KA6
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RPS6KA6
    Customized:
     lentivirus for stable overexpression of RPS6KA6
     lentivirus expression plasmids for stable overexpression of RPS6KA6
     adenovirus for overexpression of RPS6KA6
     LSBio Antibodies in human, mouse, rat for RPS6KA6
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RPS6KA6 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4