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RPS6KA5 Gene

protein-coding   GIFtS: 69
GCID: GC14M091337

Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5

(Previous names: ribosomal protein S6 kinase, 90kD, polypeptide 5)
  See RPS6KA5-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 51 2     EC 2.7.11.13 8
MSK12 3 5     Ribosomal Protein S6 Kinase, 90kD, Polypeptide 51
Nuclear Mitogen- And Stress-Activated Protein Kinase 12 3     MSPK12
90 KDa Ribosomal Protein S6 Kinase 52 3     RLPK2
RSKL2 3     Ribosomal Protein S6 Kinase Alpha-52
S6K-alpha-52 3     EC 2.7.118
RSK-Like Protein Kinase2 3     

External Ids:    HGNC: 104341   Entrez Gene: 92522   Ensembl: ENSG000001007847   OMIM: 6036075   UniProtKB: O755823   

Export aliases for RPS6KA5 gene to outside databases

Previous GC identifers: GC14M088842 GC14M085153 GC14M089327 GC14M090406 GC14M071512


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RPS6KA5 Gene:
RPS6KA5 (ribosomal protein S6 kinase, 90kDa, polypeptide 5) is a protein-coding gene. Diseases associated with RPS6KA5 include coffin-lowry syndrome. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is RPS6KA6.

UniProtKB/Swiss-Prot: KS6A5_HUMAN, O75582
Function: Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of
the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and
ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of
inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C
irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA
transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the
glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression.
In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress. In
erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its
transcriptional potential. Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability
to stimulate transcription, which may be important during development and breast tumor formation. Directly
represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in
response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several
immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of
histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1
(HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor
TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the
MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1
transcription factors. Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic
injury

Gene Wiki entry for RPS6KA5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPS6KA5 gene promoter:
         CREB   ATF-2   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPS6KA5 promoter sequence
   Search Chromatin IP Primers for RPS6KA5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPS6KA5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q31-q32.1   Ensembl cytogenetic band:  14q32.11   HGNC cytogenetic band: 14q31-q32.1

RPS6KA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS6KA5 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M091337:  view genomic region     (about GC identifiers)

Start:
91,336,799 bp from pter      End:
91,526,993 bp from pter
Size:
190,195 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KS6A5_HUMAN, O75582 (See protein sequence)
Recommended Name: Ribosomal protein S6 kinase alpha-5  
Size: 802 amino acids; 89865 Da
Cofactor: Magnesium
Subunit: Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells which transiently dissociates
following mitogenic stimulation. Also associates with MAPK14/p38-alpha. Activated RPS6KA5 associates with and
phosphorylates the NF-kappa-B p65 subunit RELA. Interacts with CREBBP and EP300
Miscellaneous: Enzyme activity requires the presence of both kinase domains
Sequence caution: Sequence=AAC69577.1; Type=Frameshift; Positions=Several;
3 PDB 3D structures from and Proteopedia for RPS6KA5:
1VZO (3D)        3KN5 (3D)        3KN6 (3D)    
Secondary accessions: O95316 Q96AF7
Alternative splicing: 2 isoforms:  O75582-1   O75582-2   

Explore the universe of human proteins at neXtProt for RPS6KA5: NX_O75582

Explore proteomics data for RPS6KA5 at MOPED

Post-translational modifications: 

  • Ser-376 and Thr-581 phosphorylation is required for kinase activity. Ser-376 and Ser-212 are autophosphorylated by
    the C-terminal kinase domain, and their phosphorylation is essential for the catalytic activity of the N-terminal
    kinase domain. Phosphorylated at Ser-360, Thr-581 and Thr-700 by MAPK1/ERK2, MAPK3/ERK1 and MAPK14/p38-alpha.
    Autophosphorylated at Ser-750, Ser-752 and Ser-758 by the N-terminal kinase domain1
  • Ubiquitinated1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for RPS6KA5 (O75582) (see all 37)
     VVHRDLK  RDIKLEN  SPFTVDG  NFAEEFT 


    See RPS6KA5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_004746.2  NP_872198.1  

    ENSEMBL proteins: 
     ENSP00000261991   ENSP00000442803   ENSP00000451305   ENSP00000402787   ENSP00000450591  
     ENSP00000451736  
    Reactome Protein details: O75582

    RPS6KA5 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant RPS6KA5 Protein
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    OriGene Custom Protein Services for RPS6KA5
    GenScript Custom Purified and Recombinant Proteins Services for RPS6KA5
    Novus Biologicals RPS6KA5 Proteins
    Novus Biologicals RPS6KA5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for RPS6KA5 

     
    antibodies-online proteins for RPS6KA5 (6 products) 

     
    antibodies-online peptides for RPS6KA5

    RPS6KA5 Antibody Products:

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    OriGene Antibodies for RPS6KA5
    OriGene Custom Antibody Services for RPS6KA5
    Novus Biologicals RPS6KA5 Antibodies
    Abcam antibodies for RPS6KA5
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for RPS6KA5
    LSBio Antibodies in human, mouse, rat for RPS6KA5
    antibodies-online antibodies for RPS6KA5 (182 products) 

    RPS6KA5 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for RPS6KA5 
    antibodies-online kits for RPS6KA5 (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: ribosomal protein S6 kinase, 90kDa, polypeptide 5
    MSK subfamily
    Other AGC kinases

    Selected InterPro protein domains (see all 8):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR000961 AGC-kinase_C
     IPR011009 Kinase-like_dom
     IPR017892 Pkinase_C

    Graphical View of Domain Structure for InterPro Entry O75582

    ProtoNet protein and cluster: O75582

    1 Blocks protein domain: IPB000961 Protein kinase C-terminal domain

    UniProtKB/Swiss-Prot: KS6A5_HUMAN, O75582
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 2 protein kinase domains


    Find genes that share domains with RPS6KA5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KS6A5_HUMAN, O75582
    Function: Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of
    the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and
    ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of
    inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C
    irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA
    transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the
    glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression.
    In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress. In
    erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its
    transcriptional potential. Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability
    to stimulate transcription, which may be important during development and breast tumor formation. Directly
    represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in
    response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several
    immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of
    histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1
    (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor
    TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the
    MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1
    transcription factors. Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic
    injury
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation at Ser-360, Thr-581 and Thr-700 by MAPK1/ERK2, MAPK3/ERK1 and
    MAPK14/p38-alpha, and by further autophosphorylation of Ser-212, Ser-376 and Ser-381 by the activated C-terminal
    kinase domain. The active N-terminal kinase domain finally phosphorylates downstream substrates, as well as
    Ser-750, Ser-752 and Ser-758 in its own C-terminal region

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0004672protein kinase activity IDA9873047
    GO:0004674protein serine/threonine kinase activity IMP12773393
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with RPS6KA5           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for RPS6KA5:
     Decreased Salmonella enterica   Decreased focal adhesion (FA)   Decreased substrate adherent c  Decreased telomerase activity 
     Decreased viability with TRAIL  Increased homologous recombina 

         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rps6ka5):
     behavior/neurological  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     integument  mortality/aging  nervous system 

    Find genes that share phenotypes with RPS6KA5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rps6ka5tm1Jsca for RPS6KA5

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RPS6KA5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RPS6KA5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RPS6KA5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RPS6KA5

    miRNA
    Products:
        
    miRTarBase miRNAs that target RPS6KA5:
    hsa-mir-27a-3p (MIRT028694), hsa-mir-101-3p (MIRT027312), hsa-mir-148a-3p (MIRT004504), hsa-mir-128-3p (MIRT022082), hsa-mir-744-5p (MIRT037609), hsa-mir-93-5p (MIRT048811), hsa-mir-19a-3p (MIRT050647)

    Block miRNA regulation of human, mouse, rat RPS6KA5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RPS6KA5 (see all 23):
    hsa-miR-142-5p hsa-miR-106a hsa-miR-128 hsa-miR-340 hsa-miR-519a hsa-miR-342-3p hsa-miR-204 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidRPS6KA5 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat RPS6KA5

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): RPS6KA5 (NM_004755)
    Sino Biological Human cDNA Clone for RPS6KA5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPS6KA5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS6KA5
    Addgene plasmids for RPS6KA5 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS6KA5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KS6A5_HUMAN, O75582: Nucleus. Cytoplasm. Note=Predominantly nuclear. Exported into cytoplasm in response to
    glucocorticoid
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IMP12628924
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA18511904
    GO:0005840ribosome ----
    GO:0016020membrane ----

    Find genes that share ontologies with RPS6KA5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RPS6KA5 About   (see all 40)  
    See pathways by source

    SuperPathContained pathways About
    1MAPK targets/ Nuclear events mediated by MAP kinases
    ERK/MAPK targets0.88
    MAP kinase activation in TLR cascade0.61
    Nuclear Events (kinase and transcription factor activation)0.88
    MAP Kinase Signaling0.31
    MAPK targets/ Nuclear events mediated by MAP kinases0.80
    CREB phosphorylation0.00
    2Toll Like Receptor 7/8 (TLR7/8) Cascade
    Toll Like Receptor 9 (TLR9) Cascade0.93
    MyD88 dependent cascade initiated on endosome0.69
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation0.93
    MyD88-independent cascade0.69
    Toll Like Receptor 7/8 (TLR7/8) Cascade0.69
    Toll Like Receptor 3 (TLR3) Cascade0.69
    3L1CAM interactions
    Axon guidance0.63
    L1CAM interactions0.36
    Developmental Biology0.63
    4ERK Signaling
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    5Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Cellular Apoptosis Pathway0.85


    Find genes that share SuperPaths with RPS6KA5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RPS6KA5 (see all 15)
        FLT3 Signaling
    MAPK Signaling
    UVB-Induced MAPK Signaling
    Mitochondrial Apoptosis
    CNTF Signaling

    1 Cell Signaling Technology (CST) Pathway for RPS6KA5
        MAP Kinase Signaling

    4 GeneGo (Thomson Reuters) Pathways for RPS6KA5
        Development EPO-induced Jak-STAT pathway
    Transcription CREB pathway
    Translation Regulation of EIF4F activity
    Development TGF-beta receptor signaling

    Selected BioSystems Pathways for RPS6KA5 (see all 11)
        EGFR1 Signaling Pathway
    Insulin Signaling
    Serotonin Receptor 4/6/7 and NR3C Signaling
    p38 MAPK Signaling Pathway
    BDNF signaling pathway


    4 Reactome Pathways for RPS6KA5
        CREB phosphorylation
    Recycling pathway of L1
    ERK/MAPK targets
    NCAM signaling for neurite out-growth


    Selected Kegg Pathways  (Kegg details for RPS6KA5) (see all 7):
        MAPK signaling pathway
    Adrenergic signaling in cardiomyocytes
    TNF signaling pathway
    Circadian entrainment
    Neurotrophin signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RPS6KA5: 
              mTOR Signaling in human mouse rat
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RPS6KA5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPS6KA5 (O755821, 2, 3 ENSP000002619914) via UniProtKB, MINT, STRING, and/or I2D (see all 140)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=2 STRING: ENSP00000352980
    HIST2H4AP628053, ENSP000003581624I2D: score=2 STRING: ENSP00000358162
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 34):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001818negative regulation of cytokine production TAS18508628
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006355regulation of transcription, DNA-templated IMP12763138

    Find genes that share ontologies with RPS6KA5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPS6KA5 (KS6A5)

    4 HMDB Compounds for RPS6KA5    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    MagnesiumMagnesium (see all 2)7439-95-4--

    Selected Novoseek inferred chemical compound relationships for RPS6KA5 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pd 169316 67.5 1 11777913 (1)
    anisomycin 65.5 3 10391889 (2), 17767420 (1)
    sb 203580 64.2 4 9873047 (1), 12628924 (1), 11243876 (1), 16531007 (1)
    pd 98,059 59 6 11777913 (1), 9873047 (1), 12628924 (1), 11243876 (1) (see all 5)
    cyclic amp 30.4 2 17767420 (1), 10706690 (1)
    serine 26.5 7 20382163 (1), 12569367 (1), 19706715 (1), 15274926 (1)
    threonine 20.2 2 20382163 (1), 15274926 (1)
    alanine 16.3 2 15010469 (1)
    calcium 0 1 17663748 (1)
    tyrosine 0 2 12421349 (1), 9873047 (1)



    Find genes that share compounds with RPS6KA5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RPS6KA5 gene (2 alternative transcripts): 
    NM_004755.2  NM_182398.1  

    Unigene Cluster for RPS6KA5:

    Ribosomal protein S6 kinase, 90kDa, polypeptide 5
    Hs.510225  [show with all ESTs]
    Unigene Representative Sequence: AB209667
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261991(uc010twi.1 uc001xys.2) ENST00000536315 ENST00000556178
    ENST00000418736(uc001xyt.3) ENST00000554206(uc010att.1) ENST00000556304
    ENST00000556594
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    hsa-miR-142-5p hsa-miR-106a hsa-miR-128 hsa-miR-340 hsa-miR-519a hsa-miR-342-3p hsa-miR-204 hsa-miR-93
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    Additional mRNA sequence: 

    AB209667.1 AF074393.1 AF080000.1 AF090421.1 AK295266.1 AK309925.1 AL050099.1 BC017187.2 

    5 DOTS entries:

    DT.113203  DT.92426019  DT.120783694  DT.91666567  DT.91696321 

    Selected AceView cDNA sequences (see all 87):

    BF892488 BE501672 AI672122 BM968829 AF074393 AA699729 AA504166 NM_004755 
    BM453259 BC017187 AI571717 NM_182398 AA663362 AI872640 BF109013 BE645029 
    F05701 AI422540 AW025866 CB159550 AA134359 BU539107 AF080000 BE538812 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for RPS6KA5    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:              -                                                                                                         
    SP2:                                                                                                                        


    ECgene alternative splicing isoforms for RPS6KA5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    RPS6KA5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATAAAAATG
    RPS6KA5 Expression
    About this image


    RPS6KA5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    RPS6KA5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPS6KA5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.510225

    UniProtKB/Swiss-Prot: KS6A5_HUMAN, O75582
    Tissue specificity: Widely expressed with high levels in heart, brain and placenta. Less abundant in lung, kidney
    and liver

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RPS6KA5: 
              mTOR Signaling in human mouse rat
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RPS6KA5 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rps6ka51 , 5 ribosomal protein S6 kinase, polypeptide 51, 5 89.43(n)1
    96.94(a)1
      12 (50.81 cM)5
    730861  NM_153587.21  NP_705815.11 
     1005497785 
    chicken
    (Gallus gallus)
    Aves RPS6KA51 ribosomal protein S6 kinase, 90kDa, polypeptide 5 82.8(n)
    91.48(a)
      423408  NM_001012587.2  NP_001012605.1 
    lizard
    (Anolis carolinensis)
    Reptilia RPS6KA56
    ribosomal protein S6 kinase, 90kDa, polypeptide 5
    80(a)
    1 ↔ 1
    1(12236421-12264083)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rps6ka51 ribosomal protein S6 kinase, 90kDa, polypeptide 5 77.33(n)
    87.23(a)
      100489041  XM_002933224.2  XP_002933270.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5651731 ribosomal protein S6 kinase alpha-5-like 71.87(n)
    79.86(a)
      565173  XM_688458.5  XP_693550.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pk17E3
    JIL-11
    protein amino acid phosphorylation
    protein serine/threonine more3
    JIL-11
    35(a)3
    50.89(n)1
    48.79(a)1
      392411  NM_001274768.11  NP_001261697.11 
    worm
    (Caenorhabditis elegans)
    Secernentea R04A9.53
    rskn-21
    homeobox\; centromeric protein E\;
    ribosomal protein more3
    rskn-21
    46(a)
    (best of 3)3
    56.5(n)1
    51.59(a)1
      X(419832-429847)3
    1725811  NM_001047180.21  NP_001040645.11 


    ENSEMBL Gene Tree for RPS6KA5 (if available)
    TreeFam Gene Tree for RPS6KA5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RPS6KA5 gene
    RPS6KA62  MAPKAPK32  MAPKAPK52  RPS6KA12  RPS6KA42  MAPKAPK22  MKNK12  MKNK22  
    RPS6KA32  RPS6KA22  
    Selected SIMAP similar genes for RPS6KA5 using alignment to 5 protein entries:     KS6A5_HUMAN (see all proteins) (see all similar genes):
    DKFZp586C1419    X-linked retinopathy protein    ZNF211    AHSA1    ASCC1    PDILT
    KIAA1651    UBE2V2    EIF3K    RPS6KA4    AGBL3    KIN27
    SH3BP1    ZNF85    PRKCZ    C14orf105    PRKACB    EIF3G

    Find genes that share paralogs with RPS6KA5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RPS6KA5 (see all 3626)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1438465651,2
    Cuntested191338433(+) GAGTCC/TGAGAA 2 S syn11Minor allele frequency- T:0.00NA 4550
    rs1890623201,2
    --91336754(+) AAATAA/TTATTC 1 -- ds50010--------
    rs1818026101,2
    --91337057(+) TGATTC/GCTGTA 1 -- ds50010--------
    rs1861449171,2
    --91337078(+) AAAAAC/TCACTT 1 -- ds50010--------
    rs1478181771,2
    --91337149(+) CACTT-/CTTTTT 1 -- ds50010--------
    rs771290621,2
    C--91337173(+) TTTTGC/TATAGG 1 -- ut310--------
    rs733225981,2
    C,F--91337182(+) GGGAAC/TGAATT 1 -- ut313Minor allele frequency- T:0.04WA CSA 122
    rs171270971,2
    C,F,H--91337463(+) ATTTCC/TCTTTA 1 -- ut31 ese313Minor allele frequency- T:0.02NA NS EA WA 1430
    rs766273951,2
    F--91337488(+) TGGTGC/TATAAG 1 -- ut311Minor allele frequency- T:0.01EA 120
    rs1904477731,2
    --91337561(+) GTGAGA/GACAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RPS6KA5 (91336799 - 91526993 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for RPS6KA5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749013CNV Deletion23290073
    esv2749012CNV Deletion23290073
    esv2749014CNV Deletion23290073
    nsv832856CNV Loss17160897
    nsv832855CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603607    OMIM disorders: --

    1 disease for RPS6KA5:    
    About MalaCards
    coffin-lowry syndrome

    1 disease from the University of Copenhagen DISEASES database for RPS6KA5:
    Coffin-Lowry syndrome

    Find genes that share disorders with RPS6KA5           About GenesLikeMe

    5 Novoseek inferred disease relationships for RPS6KA5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 26.4 2 19197368 (1)
    psoriasis 24.8 3 17255956 (1), 16543895 (1), 17495961 (1)
    necrosis 7.4 3 9873047 (1), 12628924 (1), 16543895 (1)
    tumors 0 4 9873047 (1), 12628924 (1), 16543895 (1), 18381464 (1)
    cancer 0 2 17255956 (1), 18381464 (1)

    Genetic Association Database (GAD): RPS6KA5
    Human Genome Epidemiology (HuGE) Navigator: RPS6KA5 (5 documents)

    Export disorders for RPS6KA5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RPS6KA5 gene, integrated from 10 sources (see all 153):
    (articles sorted by number of sources associating them with RPS6KA5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. (PubMed id 9687510)1, 2, 3, 9 Deak M.... Alessi D.R. (EMBO J. 1998)
    2. Assignment of a member of the ribosomal protein S6 kinase family, RPS6KA5, to human chromosome 14q31-q32.1 by radiation hybrid mapping. (PubMed id 10702687)1, 2, 3 Jiang C.... Zhao S. (Cytogenet. Cell Genet. 1999)
    3. Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS. (PubMed id 17117922)1, 2, 9 McCoy C.E.... Arthur J.S. (Biochem. J. 2007)
    4. Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1). (PubMed id 12569367)1, 2, 9 Janknecht R. (Oncogene 2003)
    5. Cloning and characterization of RLPK, a novel RSK-related protein kinase. (PubMed id 9873047)1, 2, 9 New L.... Han J. (J. Biol. Chem. 1999)
    6. MSK1 activity is controlled by multiple phosphorylation sites. (PubMed id 15568999)1, 2, 9 McCoy C.E.... Arthur J.S.C. (Biochem. J. 2005)
    7. Phosphorylation of histone H2A inhibits transcription on chromatin templates. (PubMed id 15010469)1, 2, 9 Zhang Y.... Parvin J.D. (J. Biol. Chem. 2004)
    8. Altered subcellular distribution of MSK1 induced by glucocorticoids contributes to NF-kappaB inhibition. (PubMed id 18511904)1, 2, 9 Beck I.M.... De Bosscher K. (EMBO J. 2008)
    9. Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1). (PubMed id 12628924)1, 2, 9 Vermeulen L....Haegeman G. (EMBO J. 2003)
    10. Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway. (PubMed id 12763138)1, 2, 9 Wierenga A.T.... Vellenga E. (Exp. Hematol. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9252 HGNC: 10434 AceView: RPS6KA5 Ensembl:ENSG00000100784 euGenes: HUgn9252
    ECgene: RPS6KA5 Kegg: 9252 H-InvDB: RPS6KA5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RPS6KA5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RPS6KA5 gene:
    Search GeneIP for patents involving RPS6KA5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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