Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPS6KA5 Gene

protein-coding   GIFtS: 70
GCID: GC14M091337

Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5

(Previous names: ribosomal protein S6 kinase, 90kD, polypeptide 5)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 51 2     EC 2.7.11.13 8
MSK12 3 5     Ribosomal Protein S6 Kinase, 90kD, Polypeptide 51
Nuclear Mitogen- And Stress-Activated Protein Kinase 12 3     MSPK12
90 KDa Ribosomal Protein S6 Kinase 52 3     RLPK2
RSKL2 3     Ribosomal Protein S6 Kinase Alpha-52
S6K-alpha-52 3     EC 2.7.118
RSK-Like Protein Kinase2 3     

External Ids:    HGNC: 104341   Entrez Gene: 92522   Ensembl: ENSG000001007847   OMIM: 6036075   UniProtKB: O755823   

Export aliases for RPS6KA5 gene to outside databases

Previous GC identifers: GC14M088842 GC14M085153 GC14M089327 GC14M090406 GC14M071512


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RPS6KA5 Gene: 
RPS6KA5 (ribosomal protein S6 kinase, 90kDa, polypeptide 5) is a protein-coding gene. Diseases associated with RPS6KA5 include coffin-lowry syndrome, and acute myeloid leukemia, and among its related super-pathways are MAP kinase activation in TLR cascade and Axon guidance. GO annotations related to this gene include protein serine/threonine kinase activity and magnesium ion binding. An important paralog of this gene is RPS6KA6.

UniProtKB/Swiss-Prot: KS6A5_HUMAN, O75582
Function: Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of
the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and
ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of
inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C
irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA
transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the
glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression.
In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress. In
erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its
transcriptional potential. Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability
to stimulate transcription, which may be important during development and breast tumor formation. Directly
represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in
response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several
immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of
histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1
(HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor
TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the
MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1
transcription factors. Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic
injury

Gene Wiki entry for RPS6KA5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPS6KA5 gene promoter:
         CREB   ATF-2   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPS6KA5 promoter sequence
   Search SABiosciences Chromatin IP Primers for RPS6KA5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS6KA5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q31-q32.1   Ensembl cytogenetic band:  14q32.11   HGNC cytogenetic band: 14q31-q32.1

RPS6KA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS6KA5 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M091337:  view genomic region     (about GC identifiers)

Start:
91,336,799 bp from pter      End:
91,526,993 bp from pter
Size:
190,195 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KS6A5_HUMAN, O75582 (See protein sequence)
Recommended Name: Ribosomal protein S6 kinase alpha-5  
Size: 802 amino acids; 89865 Da
Cofactor: Magnesium
Subunit: Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells which transiently dissociates
following mitogenic stimulation. Also associates with MAPK14/p38-alpha. Activated RPS6KA5 associates with and
phosphorylates the NF-kappa-B p65 subunit RELA. Interacts with CREBBP and EP300
Subcellular location: Nucleus. Cytoplasm. Note=Predominantly nuclear. Exported into cytoplasm in response to
glucocorticoid
Miscellaneous: Enzyme activity requires the presence of both kinase domains
Sequence caution: Sequence=AAC69577.1; Type=Frameshift; Positions=Several;
3 PDB 3D structures from and Proteopedia for RPS6KA5:
1VZO (3D)        3KN5 (3D)        3KN6 (3D)    
Secondary accessions: O95316 Q96AF7
Alternative splicing: 2 isoforms:  O75582-1   O75582-2   

Explore the universe of human proteins at neXtProt for RPS6KA5: NX_O75582

Explore proteomics data for RPS6KA5 at MOPED 

Post-translational modifications:

  • UniProtKB: Ser-376 and Thr-581 phosphorylation is required for kinase activity. Ser-376 and Ser-212 are autophosphorylated by
    the C-terminal kinase domain, and their phosphorylation is essential for the catalytic activity of the N-terminal
    kinase domain. Phosphorylated at Ser-360, Thr-581 and Thr-700 by MAPK1/ERK2, MAPK3/ERK1 and MAPK14/p38-alpha.
    Autophosphorylated at Ser-750, Ser-752 and Ser-758 by the N-terminal kinase domain
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75582

  • 4/37 DME Specific Peptides for RPS6KA5 (O75582) (see all 37)
     VVHRDLK  RDIKLEN  SPFTVDG  NFAEEFT 

    RPS6KA5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RPS6KA5 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_004746.2  NP_872198.1  

    ENSEMBL proteins: 
     ENSP00000261991   ENSP00000442803   ENSP00000451305   ENSP00000402787   ENSP00000450591  
     ENSP00000451736  
    Reactome Protein details: O75582
    Human Recombinant Protein Products for RPS6KA5: 
    EMD Millipore Purified and/or Recombinant RPS6KA5 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for RPS6KA5
    OriGene Protein Over-expression Lysate for RPS6KA5
    OriGene MassSpec for RPS6KA5 
    OriGene Custom Protein Services for RPS6KA5
    GenScript Custom Purified and Recombinant Proteins Services for RPS6KA5
    Novus Biologicals RPS6KA5 Proteins
    Novus Biologicals RPS6KA5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IMP12628924
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA18511904
    GO:0005840ribosome ----
    GO:0016020membrane ----

    RPS6KA5 for ontologies           About GeneDecksing



    RPS6KA5 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of RPS6KA5
    R&D Systems Antibodies for RPS6KA5 (MSK1)
    Cell Signaling Technology (CST) Antibodies for RPS6KA5  (MSK1)
    OriGene Antibodies for RPS6KA5
    OriGene Custom Antibody Services for RPS6KA5
    GenScript Custom Superior Antibodies Services for RPS6KA5
    Novus Biologicals RPS6KA5 Antibodies
    Abcam antibodies for RPS6KA5
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for RPS6KA5
    LSBio Antibodies in human, mouse, rat for RPS6KA5 

    Assay Products for RPS6KA5: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RPS6KA5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RPS6KA5
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: ribosomal protein S6 kinase, 90kDa, polypeptide 5 
    MSK subfamily
    Other AGC kinases

    5/8 InterPro protein domains (see all 8):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR000961 AGC-kinase_C
     IPR011009 Kinase-like_dom
     IPR017892 Pkinase_C

    Graphical View of Domain Structure for InterPro Entry O75582

    ProtoNet protein and cluster: O75582

    1 Blocks protein domain: IPB000961 Protein kinase C-terminal domain

    UniProtKB/Swiss-Prot: KS6A5_HUMAN, O75582
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 2 protein kinase domains


    RPS6KA5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KS6A5_HUMAN, O75582
    Function: Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of
    the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and
    ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of
    inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C
    irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA
    transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the
    glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression.
    In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress. In
    erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its
    transcriptional potential. Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability
    to stimulate transcription, which may be important during development and breast tumor formation. Directly
    represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in
    response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several
    immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of
    histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1
    (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor
    TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the
    MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1
    transcription factors. Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic
    injury
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation at Ser-360, Thr-581 and Thr-700 by MAPK1/ERK2, MAPK3/ERK1 and
    MAPK14/p38-alpha, and by further autophosphorylation of Ser-212, Ser-376 and Ser-381 by the activated C-terminal
    kinase domain. The active N-terminal kinase domain finally phosphorylates downstream substrates, as well as
    Ser-750, Ser-752 and Ser-758 in its own C-terminal region

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0004672protein kinase activity IDA9873047
    GO:0004674protein serine/threonine kinase activity IMP12773393
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI--
         
    RPS6KA5 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for RPS6KA5:
     Decreased Salmonella enterica   Decreased focal adhesion (FA)   Decreased substrate adherent c  Decreased telomerase activity 
     Decreased viability with TRAIL  Increased homologous recombina 

         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rps6ka5):
     behavior/neurological  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     integument  mortality/aging  nervous system 

    RPS6KA5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rps6ka5tm1Jsca for RPS6KA5

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RPS6KA5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RPS6KA5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RPS6KA5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RPS6KA5 

    miRNA
    Products:
        
    miRTarBase miRNAs that target RPS6KA5:
    hsa-mir-148a (MIRT004504)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPS6KA5
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate RPS6KA5 (see all 23):
    hsa-miR-142-5p hsa-miR-106a hsa-miR-128 hsa-miR-340 hsa-miR-519a hsa-miR-342-3p hsa-miR-204 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidRPS6KA5 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RPS6KA5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS6KA5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RPS6KA5
    Sirion Biotech Customized adenovirus for overexpression of RPS6KA5

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RPS6KA5 (see all 15)
    OriGene ORF clones in mouse, rat for RPS6KA5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RPS6KA5 (NM_004755)
    Sino Biological Human cDNA Clone for RPS6KA5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPS6KA5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS6KA5
    Sirion Biotech Customized lentivirus for stable overexpression of RPS6KA5 
                         Customized lentivirus expression plasmids for stable overexpression of RPS6KA5 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RPS6KA5
    Search LifeMap BioReagents cell lines for RPS6KA5
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS6KA5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RPS6KA5 About   (see all 40)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1TRAF6 Mediated Induction of proinflammatory cytokines
    Toll Like Receptor 5 (TLR5) Cascade0.93
    MyD88-independent cascade 0.87
    MyD88 cascade initiated on plasma membrane0.93
    Toll Like Receptor 3 (TLR3) Cascade0.87
    Toll Like Receptor 10 (TLR10) Cascade0.93
    Toll Like Receptor 4 (TLR4) Cascade0.87
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation0.93
    Toll-Like Receptors Cascades0.87
    2Axon guidance
    Axon guidance0.69
    Recycling pathway of L10.38
    Developmental Biology0.69
    Signal transduction by L10.32
    L1CAM interactions0.39
    3ERK/MAPK targets
    ERK/MAPK targets0.88
    MAPK targets/ Nuclear events mediated by MAP kinases0.80
    Nuclear Events (kinase and transcription factor activation)0.88
    4Rho Family GTPases
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    5Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Cellular Apoptosis Pathway0.85

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 EMD Millipore Pathways for RPS6KA5
        Histone modification
    Development EPO-induced Jak-STAT pathway
    Transcription CREB pathway
    Development TGF-beta receptor signaling
    Translation Regulation activity of EIF4F

    5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RPS6KA5 (see all 15)
        FLT3 Signaling
    MAPK Signaling
    UVB-Induced MAPK Signaling
    Mitochondrial Apoptosis
    CNTF Signaling

    1 Cell Signaling Technology (CST) Pathway for RPS6KA5
        MAP Kinase Signaling

    4 GeneGo (Thomson Reuters) Pathways for RPS6KA5
        Development EPO-induced Jak-STAT pathway
    Transcription CREB pathway
    Translation Regulation of EIF4F activity
    Development TGF-beta receptor signaling

    5/10 BioSystems Pathways for RPS6KA5 (see all 10)
        EGFR1 Signaling Pathway
    Insulin Signaling
    Serotonin Receptor 4/6/7 and NR3C Signaling
    p38 MAPK Signaling Pathway
    BDNF signaling pathway


    5/34        Reactome Pathways for RPS6KA5 (see all 34)
        CREB phosphorylation
    L1CAM interactions
    Toll Like Receptor 2 (TLR2) Cascade
    Toll Like Receptor TLR6:TLR2 Cascade
    Signal transduction by L1


    5/6         Kegg Pathways  (Kegg details for RPS6KA5) (see all 6):
        MAPK signaling pathway
    TNF signaling pathway
    Circadian entrainment
    Neurotrophin signaling pathway
    MicroRNAs in cancer


    RPS6KA5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RPS6KA5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/120 Interacting proteins for RPS6KA5 (O755821, 2, 3 ENSP000002619914) via UniProtKB, MINT, STRING, and/or I2D (see all 120)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=2 STRING: ENSP00000352980
    HIST2H4AP628053, ENSP000003581624I2D: score=2 STRING: ENSP00000358162
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    About this table

    Gene Ontology (GO): 5/36 biological process terms (GO ID links to tree view) (see all 36):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001818negative regulation of cytokine production TAS18508628
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006355regulation of transcription, DNA-dependent IMP12763138

    RPS6KA5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RPS6KA5 for compounds           About GeneDecksing

    EMD Millipore small molecules for RPS6KA5:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RPS6KA5 (KS6A5)

    4 HMDB Compounds for RPS6KA5    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    MagnesiumMagnesium (see all 2)7439-95-4--

    10/11 Novoseek inferred chemical compound relationships for RPS6KA5 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pd 169316 67.5 1 11777913 (1)
    anisomycin 65.5 3 10391889 (2), 17767420 (1)
    sb 203580 64.2 4 9873047 (1), 12628924 (1), 11243876 (1), 16531007 (1)
    pd 98,059 59 6 11777913 (1), 9873047 (1), 12628924 (1), 11243876 (1) (see all 5)
    cyclic amp 30.4 2 17767420 (1), 10706690 (1)
    serine 26.5 7 20382163 (1), 12569367 (1), 19706715 (1), 15274926 (1)
    threonine 20.2 2 20382163 (1), 15274926 (1)
    alanine 16.3 2 15010469 (1)
    calcium 0 1 17663748 (1)
    tyrosine 0 2 12421349 (1), 9873047 (1)

    Search CenterWatch for drugs/clinical trials and news about RPS6KA5 / KS6A5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RPS6KA5 gene (2 alternative transcripts): 
    NM_004755.2  NM_182398.1  

    Unigene Cluster for RPS6KA5:

    Ribosomal protein S6 kinase, 90kDa, polypeptide 5
    Hs.510225  [show with all ESTs]
    Unigene Representative Sequence: AB209667
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261991(uc010twi.1 uc001xys.2) ENST00000536315 ENST00000556178
    ENST00000418736(uc001xyt.3) ENST00000554206(uc010att.1) ENST00000556304
    ENST00000556594

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPS6KA5
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate RPS6KA5 (see all 23):
    hsa-miR-142-5p hsa-miR-106a hsa-miR-128 hsa-miR-340 hsa-miR-519a hsa-miR-342-3p hsa-miR-204 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidRPS6KA5 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RPS6KA5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS6KA5
    Clone
    Products:
         
    OriGene clones in human, mouse for RPS6KA5 (see all 15)
    OriGene ORF clones in mouse, rat for RPS6KA5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RPS6KA5 (NM_004755)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPS6KA5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS6KA5
    Sirion Biotech Customized lentivirus for stable overexpression of RPS6KA5 
                         Customized lentivirus expression plasmids for stable overexpression of RPS6KA5 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RPS6KA5
    OriGene qSTAR qPCR primer pairs in human, mouse for RPS6KA5
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RPS6KA5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS6KA5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS6KA5

    Additional mRNA sequence: 

    AB209667.1 AF074393.1 AF080000.1 AF090421.1 AK295266.1 AK309925.1 AL050099.1 BC017187.2 

    5 DOTS entries:

    DT.113203  DT.92426019  DT.120783694  DT.91666567  DT.91696321 

    24/87 AceView cDNA sequences (see all 87):

    AW025866 AI422540 F05701 BE645029 BF109013 AI872640 AA663362 NM_182398 
    AI571717 BC017187 BM453259 NM_004755 AA504166 AA699729 AF074393 BM968829 
    AI672122 BE501672 BF892488 BG684373 BQ677333 AL050099 BX111280 AW971860 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for RPS6KA5    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:              -                                                                                                         
    SP2:                                                                                                                        


    ECgene alternative splicing isoforms for RPS6KA5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPS6KA5 expression in normal human tissues (normalized intensities)      RPS6KA5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATAAAAATG
    RPS6KA5 Expression
    About this image


    RPS6KA5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/27 selected tissues (see all 27) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
             cerebellum   
     
     Epithelium
             cervix, uterine ; squamous epithelial cells   
             breast epithelium   
     
     Breast
             breast ; myoepithelial cells   
             breast epithelium   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Uterus
             uterus, post-menopause ; glandular cells   

    See RPS6KA5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPS6KA5

    SOURCE GeneReport for Unigene cluster: Hs.510225

    UniProtKB/Swiss-Prot: KS6A5_HUMAN, O75582
    Tissue specificity: Widely expressed with high levels in heart, brain and placenta. Less abundant in lung, kidney
    and liver

        SABiosciences Expression via Pathway-Focused PCR Arrays including RPS6KA5: 
              mTOR Signaling in human mouse rat
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RPS6KA5
    OriGene qSTAR qPCR primer pairs in human, mouse for RPS6KA5
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RPS6KA5
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS6KA5
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS6KA5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS6KA5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RPS6KA5 gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rps6ka51 , 5 ribosomal protein S6 kinase, polypeptide 51, 5 89.37(n)1
    96.62(a)1
      12 (50.81 cM)5
    730861  NM_153587.21  NP_705815.11 
     1005497785 
    chicken
    (Gallus gallus)
    Aves RPS6KA51 ribosomal protein S6 kinase, 90kDa, polypeptide 5 82.17(n)
    90.72(a)
      423408  NM_001012587.1  NP_001012605.1 
    lizard
    (Anolis carolinensis)
    Reptilia RPS6KA56
    Ribosomal protein S6 kinase
    80(a)
    1 ↔ 1
    1(12236421-12264083)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5651731 ribosomal protein S6 kinase alpha-5-like 70.67(n)
    78.03(a)
      565173  XM_688458.4  XP_693550.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pk17E3
    JIL-11
    protein amino acid phosphorylation
    protein serine/threonine more3
    CG6297-PA1
    35(a)3
    50.05(n)1
    47.45(a)1
      392411  NM_140175.21  NP_648432.11 
    worm
    (Caenorhabditis elegans)
    Secernentea R04A9.53
    rskn-21
    homeobox\; centromeric protein E\;
    ribosomal protein more3
    Protein RSKN-21
    46(a)
    (best of 3)3
    55.62(n)1
    50.85(a)1
      X(419832-429847)3
    1725811  NM_001047180.11  NP_001040645.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YPK16
    YPK26
    Serine/threonine protein kinase that phosphorylate...
    Protein kinase with similarity to serine/threonine...
    22(a)
    22(a)
    many ↔ many
    many ↔ many
    XI(205707-207749)
    XIII(473420-475453)


    ENSEMBL Gene Tree for RPS6KA5 (if available)
    TreeFam Gene Tree for RPS6KA5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPS6KA5 gene
    RPS6KA62  AKT12  RPS6KB12  SGK32  C8orf44-SGK32  RPS6KA12  SGK22  AKT32  
    RPS6KA42  SGK12  RPS6KB22  RPS6KA22  RPS6KA32  AKT22  
    18/121 SIMAP similar genes for RPS6KA5 using alignment to 5 protein entries:     KS6A5_HUMAN (see all proteins) (see all similar genes):
    DKFZp586C1419    X-linked retinopathy protein    ZNF211    AHSA1    ASCC1    PDILT
    KIAA1651    UBE2V2    EIF3K    RPS6KA4    AGBL3    KIN27
    SH3BP1    ZNF85    TBCB    PRKCZ    C14orf105    PRKACB

    RPS6KA5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3626 SNPs in RPS6KA5 are shown (see all 3626)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1438465651,2
    Cuntested191338433(+) GAGTCC/TGAGAA 2 S syn11Minor allele frequency- T:0.00NA 4550
    rs1890623201,2
    --91336754(+) AAATAA/TTATTC 1 -- ds50010--------
    rs1818026101,2
    --91337057(+) TGATTC/GCTGTA 1 -- ds50010--------
    rs1861449171,2
    --91337078(+) AAAAAC/TCACTT 1 -- ds50010--------
    rs1478181771,2
    --91337149(+) CACTT-/CTTTTT 1 -- ds50010--------
    rs771290621,2
    C--91337173(+) TTTTGC/TATAGG 1 -- ut310--------
    rs733225981,2
    C,F--91337182(+) GGGAAC/TGAATT 1 -- ut313Minor allele frequency- T:0.04WA CSA 122
    rs171270971,2
    C,F,H--91337463(+) ATTTCC/TCTTTA 1 -- ut31 ese313Minor allele frequency- T:0.02NA NS EA WA 1430
    rs766273951,2
    F--91337488(+) TGGTGC/TATAAG 1 -- ut311Minor allele frequency- T:0.01EA 120
    rs1904477731,2
    --91337561(+) GTGAGA/GACAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RPS6KA5 (91336799 - 91526993 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for RPS6KA5:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2749013CNV Deletion23290073
    esv2749012CNV Deletion23290073
    esv2749014CNV Deletion23290073
    nsv832856CNV Loss17160897
    nsv832855CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RPS6KA5
    DNA2.0 Custom Variant and Variant Library Synthesis for RPS6KA5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603607    OMIM disorders: --

    16 diseases for RPS6KA5:    About MalaCards
    coffin-lowry syndrome    acute myeloid leukemia    myeloid leukemia    alcoholism
    colon cancer    rheumatoid arthritis    pancreatic cancer    arthritis
    alzheimer's disease    pancreatitis    leukemia    prostate cancer
    prostatitis    endotheliitis    breast cancer    neuronitis

    1 disease from the University of Copenhagen DISEASES database for RPS6KA5:
    Coffin-Lowry syndrome

    RPS6KA5 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    5 Novoseek inferred disease relationships for RPS6KA5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 26.4 2 19197368 (1)
    psoriasis 24.8 3 17255956 (1), 16543895 (1), 17495961 (1)
    necrosis 7.4 3 9873047 (1), 12628924 (1), 16543895 (1)
    tumors 0 4 9873047 (1), 12628924 (1), 16543895 (1), 18381464 (1)
    cancer 0 2 17255956 (1), 18381464 (1)

    Genetic Association Database (GAD): RPS6KA5
    Human Genome Epidemiology (HuGE) Navigator: RPS6KA5 (5 documents)

    Export disorders for RPS6KA5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPS6KA5 gene, integrated from 9 sources (see all 151):
    (articles sorted by number of sources associating them with RPS6KA5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. (PubMed id 9687510)1, 2, 3, 9 Deak M.... Alessi D.R. (1998)
    2. Assignment of a member of the ribosomal protein S6 kinase family, RPS6KA5, to human chromosome 14q31-q32.1 by radiation hybrid mapping. (PubMed id 10702687)1, 2, 3 Jiang C.... Zhao S. (1999)
    3. Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS. (PubMed id 17117922)1, 2, 9 McCoy C.E....Arthur J.S. (2007)
    4. Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1). (PubMed id 12569367)1, 2, 9 Janknecht R. (2003)
    5. Cloning and characterization of RLPK, a novel RSK-related protein kinase. (PubMed id 9873047)1, 2, 9 New L.... Han J. (1999)
    6. MSK1 activity is controlled by multiple phosphorylation sites. (PubMed id 15568999)1, 2, 9 McCoy C.E.... Arthur J.S.C. (2005)
    7. Phosphorylation of histone H2A inhibits transcription on chromatin templates. (PubMed id 15010469)1, 2, 9 Zhang Y.... Parvin J.D. (2004)
    8. Altered subcellular distribution of MSK1 induced by glucocorticoids contributes to NF-kappaB inhibition. (PubMed id 18511904)1, 2, 9 Beck I.M....De Bosscher K. (2008)
    9. Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1). (PubMed id 12628924)1, 2, 9 Vermeulen L....Haegeman G. (2003)
    10. Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway. (PubMed id 12763138)1, 2, 9 Wierenga A.T....Vellenga E. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9252 HGNC: 10434 AceView: RPS6KA5 Ensembl:ENSG00000100784 euGenes: HUgn9252
    ECgene: RPS6KA5 Kegg: 9252 H-InvDB: RPS6KA5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPS6KA5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RPS6KA5 gene:
    Search GeneIP for patents involving RPS6KA5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore small molecules (inhibitor) for RPS6KA5
     EMD Millipore Purified and/or Recombinant RPS6KA5 Protein
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of RPS6KA5
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for RPS6KA5 (MSK1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RPS6KA5   OriGene RNAi products in human, mouse, rat for RPS6KA5  
     OriGene qPCR primer pairs and template standards for RPS6KA5   OriGene Protein Over-expression Lysate for RPS6KA5  
     OriGene MassSpec something-or-other for RPS6KA5   OriGene clones in human, mouse for RPS6KA5  
     OriGene qSTAR qPCR primer pairs in human, mouse for RPS6KA5   OriGene Purified Protein for RPS6KA5  
     OriGene ORF clones in mouse, rat for RPS6KA5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RPS6KA5   OriGene Custom Protein Services for RPS6KA5  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RPS6KA5
     QIAGEN SeqTarget long-range PCR primers for resequencing RPS6KA5
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS6KA5
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS6KA5
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS6KA5
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS6KA5
     GenScript Custom Purified and Recombinant Proteins Services for RPS6KA5 GenScript cDNA clones with any tag delivered in your preferred vector for RPS6KA5
     GenScript Custom Assay Services for RPS6KA5 GenScript Custom Superior Antibodies Services for RPS6KA5
     GenScript Custom overexpressing Cell Line Services for RPS6KA5 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for RPS6KA5  (MSK1)

     Regulatory tfbs in RPS6KA5 promoter
     Search Chromatin IP Primers for RPS6KA5
     RT2 qPCR Primer Assay in human, mouse, rat RPS6KA5
     GNC Network for RPS6KA5
     SABiosciences PCR Arrays including human, mouse, rat RPS6KA5
     Search Tocris compounds for RPS6KA5 (KS6A5)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for RPS6KA5
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RPS6KA5 antibodies
     RPS6KA5 proteins
     RPS6KA5 lysates
     Antibodies for RPS6KA5
     See all of Abcam's Antibodies, Kits and Proteins for RPS6KA5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for RPS6KA5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS6KA5
     SwitchGear 3'UTR luciferase reporter plasmids for RPS6KA5
     SwitchGear Promoter luciferase reporter plasmids for RPS6KA5
     ThermoFisher Antibodies for RPS6KA5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS6KA5
     inGenious Targeting Laboratory - Custom generated mouse model solutions for RPS6KA5
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RPS6KA5
    Customized:
     lentivirus for stable overexpression of RPS6KA5
     lentivirus expression plasmids for stable overexpression of RPS6KA5
     adenovirus for overexpression of RPS6KA5
     LSBio Antibodies in human, mouse, rat for RPS6KA5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RPS6KA5 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4