RPS6KA5 Gene
protein-coding GIFtS: 67
GCID: GC14M091337
|
|
ribosomal protein S6 kinase, 90kDa, polypeptide 5(Previous names: ribosomal protein S6 kinase, 90kD, polypeptide 5 )
| |
Aliases
for RPS6KA5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 51 2 | | RSK-Like Protein Kinase2 3 | | MSK11 2 3 5 | | EC 2.7.11.13 8 | | RLPK1 2 | | Ribosomal Protein S6 Kinase, 90kD, Polypeptide 51 | | Nuclear Mitogen- And Stress-Activated Protein Kinase 12 3 | | MSPK12 | | 90 KDa Ribosomal Protein S6 Kinase 52 3 | | Ribosomal Protein S6 Kinase Alpha-52 | | RSKL2 3 | | EC 2.7.118 | | S6K-Alpha-51 | | |
Export aliases for RPS6KA5 gene to outside databasesPrevious GC identifers: GC14M088842 GC14M085153 GC14M089327 GC14M090406 GC14M071512 |
Summaries
for RPS6KA5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: KS6A5_HUMAN, O75582Function: Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of thetranscription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81,and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatorygenes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermalgrowth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity inresponse to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 andcontributes to RELA inhibition and repression of inflammatory gene expression. In skeletal myoblasts is required forphosphorylation of RELA at 'Ser-276' during oxidative stress. In erythropoietin-stimulated cells, is necessary for the'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential. Phosphorylates ETV1/ER81 at'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important duringdevelopment and breast tumor formation. Directly represses transcription via phosphorylation of 'Ser-1' of histoneH2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in thetranscriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. Mayalso phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobilitygroup protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-likereceptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription ofthe MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1transcription factors. Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury
Gene Wiki entry for RPS6KA5
|
Genomic Views
for RPS6KA5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RPS6KA5 gene promoter:
CREB ATF-2 deltaCREB c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for RPS6KA5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS6KA5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q31-q32.1 Ensembl cytogenetic band: 14q32.11 HGNC cytogenetic band: 14q31-q32.1RPS6KA5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M091337: view genomic region
(about GC identifiers)
Start:
|
91,336,799 bp from pter |
End:
|
91,526,993 bp from pter |
Size:
|
190,195 bases |
Orientation:
|
minus strand |
|
Proteins
for RPS6KA5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KS6A5_HUMAN, O75582 (See
protein sequence)Recommended Name: Ribosomal protein S6 kinase alpha-5 Size: 802 amino acids; 89865 Da
Cofactor: Magnesium
Subunit: Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells which transiently dissociatesfollowing mitogenic stimulation. Also associates with MAPK14/p38-alpha. Activated RPS6KA5 associates with andphosphorylates the NF-kappa-B p65 subunit RELA. Interacts with CREBBP and EP300
Subcellular location: Nucleus. Cytoplasm. Note=Predominantly nuclear. Exported into cytoplasm in response toglucocorticoid
Miscellaneous: Enzyme activity requires the presence of both kinase domains
Sequence caution: Sequence=AAC69577.1; Type=Frameshift; Positions=Several;
3 PDB 3D structures from  and Proteopedia  for RPS6KA5:1VZO (3D)
3KN5 (3D)
3KN6 (3D)
Secondary accessions: O95316 Q96AF7Alternative splicing: 2 isoforms: O75582-1 O75582-2 Explore the universe of human proteins at neXtProt for RPS6KA5: NX_O75582
Post-translational modifications:
Ser-376 and Thr-581 phosphorylation is required for kinase activity. Ser-376 and Ser-212 are autophosphorylated by theC-terminal kinase domain, and their phosphorylation is essential for the catalytic activity of the N-terminal kinasedomain. Phosphorylated at Ser-360, Thr-581 and Thr-700 by MAPK1/ERK2, MAPK3/ERK1 and MAPK14/p38-alpha.Autophosphorylated at Ser-750, Ser-752 and Ser-758 by the N-terminal kinase domain1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75582
4/37 DME Specific Peptides for RPS6KA5 (O75582) (see all 37)
RPS6KA5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_004746.2 NP_872198.1
ENSEMBL proteins: ENSP00000261991 ENSP00000442803 ENSP00000451305 ENSP00000402787 ENSP00000450591 ENSP00000451736 Reactome Protein details: O75582
Human Recombinant Protein Products for RPS6KA5:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
RPS6KA5 for ontologies About GeneDecksing
RPS6KA5 Antibody Products:
Assay Products for RPS6KA5: |
Protein
Domains /
Families
for RPS6KA5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RPS6KA5 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry O75582ProtoNet protein and cluster: O75582 1 Blocks protein family: IPB000961 Protein kinase C-terminal domain
UniProtKB/Swiss-Prot: KS6A5_HUMAN, O75582Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamilySimilarity: Contains 1 AGC-kinase C-terminal domainSimilarity: Contains 2 protein kinase domains |
Function
for RPS6KA5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: KS6A5_HUMAN, O75582Function: Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of thetranscription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81,and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatorygenes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermalgrowth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity inresponse to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 andcontributes to RELA inhibition and repression of inflammatory gene expression. In skeletal myoblasts is required forphosphorylation of RELA at 'Ser-276' during oxidative stress. In erythropoietin-stimulated cells, is necessary for the'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential. Phosphorylates ETV1/ER81 at'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important duringdevelopment and breast tumor formation. Directly represses transcription via phosphorylation of 'Ser-1' of histoneH2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in thetranscriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. Mayalso phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobilitygroup protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-likereceptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription ofthe MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1transcription factors. Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injuryCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Activated by phosphorylation at Ser-360, Thr-581 and Thr-700 by MAPK1/ERK2, MAPK3/ERK1 andMAPK14/p38-alpha, and by further autophosphorylation of Ser-212, Ser-376 and Ser-381 by the activated C-terminalkinase domain. The active N-terminal kinase domain finally phosphorylates downstream substrates, as well as Ser-750,Ser-752 and Ser-758 in its own C-terminal region Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
RPS6KA5 for ontologies About GeneDecksing
Phenotypes:
6 GenomeRNAi human phenotypes for RPS6KA5:
8 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Rps6ka5):
RPS6KA5 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Rps6ka5tm1Jsca for RPS6KA5
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPS6KA5 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPS6KA5 (see all 4)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): RPS6KA5 (NM_004755) | |  | Sino Biological Human cDNA Clone for RPS6KA5 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPS6KA5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS6KA5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS6KA5 |
|
Pathways & Interactions
for RPS6KA5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/36 super-pathways (see all 36) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | TRAF6 Mediated Induction of proinflammatory cytokines | | | 2 | Axon guidance | | | 3 | ERK/MAPK targets | | | 4 | Rho Family GTPases | | | 5 | Development_TGF-beta receptor signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 EMD Millipore Pathways for RPS6KA5
5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RPS6KA5 (see all 15)
1 
Cell Signaling Technology (CST) Pathway for RPS6KA5
4  GeneGo (Thomson Reuters) Pathways for RPS6KA5
5/9  BioSystems Pathways for RPS6KA5 (see all 9)
5/34 
Reactome Pathways for RPS6KA5 (see all 34)
3 
Kegg Pathways (Kegg details for RPS6KA5):
RPS6KA5 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RPS6KA5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/113 Interacting proteins for RPS6KA5 (O755821, 2, 3 ENSP000002619914) via UniProtKB, MINT, STRING, and/or I2D (see all 113)About this table
Gene Ontology (GO): 5/32 biological process terms (GO ID links to tree view) (see all 32): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001818 | negative regulation of cytokine production |
TAS | 18508628 | | GO:0002224 | toll-like receptor signaling pathway |
TAS | -- | | GO:0002755 | MyD88-dependent toll-like receptor signaling pathway |
TAS | -- | | GO:0002756 | MyD88-independent toll-like receptor signaling pathway |
TAS | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IMP | 12763138 |
RPS6KA5 for ontologies About GeneDecksing
|
Drugs & Compounds
for RPS6KA5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
RPS6KA5 for compounds About GeneDecksing
 Browse Tocris compounds for RPS6KA5
4 HMDB Compounds for RPS6KA5 About this table
10/11 Novoseek chemical compound relationships for RPS6KA5 gene (see all 11) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| pd 169316 |
67.5 |
1 |
11777913 (1) |
| anisomycin |
65.5 |
3 |
10391889 (2), 17767420 (1) |
| sb 203580 |
64.2 |
4 |
9873047 (1), 12628924 (1), 11243876 (1), 16531007 (1) |
| pd 98,059 |
59 |
6 |
11777913 (1), 9873047 (1), 12628924 (1), 11243876 (1) (see all 5) |
| cyclic amp |
30.4 |
2 |
17767420 (1), 10706690 (1) |
| serine |
26.5 |
7 |
20382163 (1), 12569367 (1), 19706715 (1), 15274926 (1) |
| threonine |
20.2 |
2 |
20382163 (1), 15274926 (1) |
| alanine |
16.3 |
2 |
15010469 (1) |
| calcium |
0 |
1 |
17663748 (1) |
| tyrosine |
0 |
2 |
12421349 (1), 9873047 (1) |
Search CenterWatch for drugs/clinical trials and news about RPS6KA5 / KS6A5
|
Transcripts
for RPS6KA5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RPS6KA5 gene (2 alternative transcripts): NM_004755.2 NM_182398.1 Unigene Cluster for RPS6KA5: Ribosomal protein S6 kinase, 90kDa, polypeptide 5 Hs.510225 [show with all ESTs]Unigene Representative Sequence: AB2096677 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000261991(uc010twi.1 uc001xys.2) ENST00000536315 ENST00000556178
ENST00000418736(uc001xyt.3) ENST00000554206(uc010att.1) ENST00000556304
ENST00000556594
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPS6KA5 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPS6KA5 (see all 4)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): RPS6KA5 (NM_004755) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPS6KA5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS6KA5 |
Additional cDNA sequence: AB209667.1 AF074393.1 AF080000.1 AF090421.1 AK295266.1 AK309925.1 AL050099.1 BC017187.2 5 DOTS entries: DT.113203 DT.92426019 DT.120783694 DT.91666567 DT.91696321 24/87 AceView cDNA sequences (see all 87): AI872640 AA663362 NM_182398 BC017187 AI571717 BM453259 NM_004755 AA504166 AA699729 AF074393 BM968829 BE501672 AI672122 BF109013 BF892488 BE645029 AI422540 AW025866 F05701 BM690068 CD244931 BU954559 AW298331 AI382181
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for RPS6KA5 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 |
|---|
|
| SP1: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RPS6KA5
|
Expression
for RPS6KA5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RPS6KA5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATAAAAATG
About this image
See RPS6KA5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RPS6KA5
SOURCE GeneReport for Unigene cluster: Hs.510225
UniProtKB/Swiss-Prot: KS6A5_HUMAN, O75582Tissue specificity: Widely expressed with high levels in heart, brain and placenta. Less abundant in lung, kidney andliver
SABiosciences Expression via Pathway-Focused PCR Arrays including RPS6KA5:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPS6KA5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RPS6KA5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS6KA5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS6KA5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS6KA5 |
Orthologs
for RPS6KA5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RPS6KA5 gene from 7/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
RPS6KA51 |
ribosomal protein S6 kinase, 90kDa, polypeptide 5 |
82.17(n)
90.72(a) |
|
423408 NM_001012587.1 NP_001012605.1 |
lizard
(Anolis carolinensis) |
Reptilia |
RPS6KA56 |
-- |
80(a) |
1 ↔ 1 |
1(12236421-12264083) |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC5651731 |
ribosomal protein S6 kinase alpha-5-like |
70.67(n)
78.03(a) |
|
565173 XM_688458.4 XP_693550.4 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Pk17E3
JIL-11 |
protein amino acid phosphorylation protein
serine/threonine more3
CG6297-PA1 |
35(a)3
50.05(n)1
47.45(a)1 |
|
392411 NM_140175.21 NP_648432.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
R04A9.53
rskn-21 |
homeobox\; centromeric protein E\; ribosomal
protein more3
Protein RSKN-21 |
46(a)
(best of 3)3
55.62(n)1
50.85(a)1 |
|
X(419832-429847)3
1725811 NM_001047180.11 NP_001040645.11 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
S6K26ATPK16 |
serine/threonine-protein kinase AtPK1/AtPK6 |
34(a)33(a) |
many ↔ manymany ↔ many |
3(2648509-2651160) 3(2651447-2654212) |
rice
(Oryza sativa) |
Liliopsida |
---- |
AGC_AGC_other_RS6K_like.1 - ACG kinases include ho...AGC_AGC_other_RS6K_like.2 - ACG kinases include ho... |
31(a)30(a) |
many ↔ manymany ↔ many |
3(12338898-12343059) 7(28854803-28858816) |
ENSEMBL Gene Tree for RPS6KA5 (if available)
TreeFam Gene Tree for RPS6KA5 (if available) |
Paralogs
for RPS6KA5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RPS6KA5 gene
- AKT12 RPS6KA62 RPS6KB12 SGK32 SGK22 RPS6KA12 AKT32 RPS6KA42
- SGK12 RPS6KB22 RPS6KA22 AKT22 RPS6KA32
18/118 SIMAP similar genes for RPS6KA5 using alignment to 5 protein entries: KS6A5_HUMAN (see all proteins)
(see all similar genes):DKFZp586C1419 X-linked retinopathy protein ZNF211 AHSA1 ASCC1 PDILT
KIAA1651 UBE2V2 EIF3K RPS6KA4 AGBL3 KIN27
SH3BP1 TBCB PRKCZ C14orf105 PRKACB EIF3G
RPS6KA5 for paralogs About GeneDecksing
|
Genomic Variants
for RPS6KA5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RPS6KA5 (91336799 - 91526993 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RPS6KA5
1 CNV: 4845 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPS6KA5 |
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Disorders
/ Diseases
for RPS6KA5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RPS6KA5 for disorders About GeneDecksing
OMIM gene information: 603607
OMIM disorders: --
19  diseases for RPS6KA5: About MalaCardscoffin-lowry syndrome acute myeloid leukemia myeloid leukemia rheumatoid arthritis
psoriasis alzheimer's disease colon cancer arthritis
lung carcinoma pancreatic cancer leukemia prostate cancer
breast cancer pancreatitis cholesterol prostatitis
carcinoma neuronitis alcoholism
1 disease from the University of Copenhagen DISEASES database for RPS6KA5:Coffin-Lowry syndrome 5 Novoseek disease relationships for RPS6KA5 gene About this table
Human Genome Epidemiology (HuGE) Navigator: RPS6KA5 (5 documents)
Export disorders for RPS6KA5 gene to outside databases
|
Publications
for RPS6KA5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RPS6KA5 gene, integrated from 9 sources (see all 147):
(articles sorted by number of sources associating them with RPS6KA5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. (PubMed id 9687510)1, 2, 3, 9 Deak M.... Alessi D.R. (1998)
- Assignment of a member of the ribosomal protein S6 kinase family, RPS6KA5, to human chromosome 14q31-q32.1 by radiation hybrid mapping. (PubMed id 10702687)1, 2, 3 Jiang C.... Zhao S. (1999)
- Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS. (PubMed id 17117922)1, 2, 9 McCoy C.E....Arthur J.S. (2007)
- Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1). (PubMed id 12569367)1, 2, 9 Janknecht R. (2003)
- Cloning and characterization of RLPK, a novel RSK-related protein kinase. (PubMed id 9873047)1, 2, 9 New L.... Han J. (1999)
- MSK1 activity is controlled by multiple phosphorylation sites. (PubMed id 15568999)1, 2, 9 McCoy C.E.... Arthur J.S.C. (2005)
- Phosphorylation of histone H2A inhibits transcription on chromatin templates. (PubMed id 15010469)1, 2, 9 Zhang Y.... Parvin J.D. (2004)
- Altered subcellular distribution of MSK1 induced by glucocorticoids contributes to NF-kappaB inhibition. (PubMed id 18511904)1, 2, 9 Beck I.M....De Bosscher K. (2008)
- Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1). (PubMed id 12628924)1, 2, 9 Vermeulen L....Haegeman G. (2003)
- Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway. (PubMed id 12763138)1, 2, 9 Wierenga A.T....Vellenga E. (2003)
|
External Searches for RPS6KA5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
|
Genome Databases showing RPS6KA5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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|
|
Other Databases showing RPS6KA5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RPS6KA5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RPS6KA5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RPS6KA5 gene:
Search GeneIP for patents involving RPS6KA5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RPS6KA5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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