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RPS6KA4 Gene

protein-coding   GIFtS: 70
GCID: GC11P064126

Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 4

(Previous names: ribosomal protein S6 kinase, 90kD, polypeptide 4)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 41 2     EC 2.7.11.13 8
MSK22 3 5     Ribosomal Protein S6 Kinase, 90kD, Polypeptide 41
RSKB2 3 5     RSK-B2
Nuclear Mitogen- And Stress-Activated Protein Kinase 22 3     Mitogen- And Stress-Activated Protein Kinase 22
Ribosomal Protein Kinase B2 3     Ribosomal Protein S6 Kinase Alpha 42
90 KDa Ribosomal Protein S6 Kinase 42 3     Ribosomal Protein S6 Kinase Alpha-42
S6K-alpha-42 3     EC 2.7.118

External Ids:    HGNC: 104331   Entrez Gene: 89862   Ensembl: ENSG000001623027   OMIM: 6036065   UniProtKB: O756763   

Export aliases for RPS6KA4 gene to outside databases

Previous GC identifers: GC11P066642 GC11P065808 GC11P064377 GC11P063902 GC11P063884 GC11P060454


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RPS6KA4 Gene:
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase
contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and
c-fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly
characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for RPS6KA4 Gene:
RPS6KA4 (ribosomal protein S6 kinase, 90kDa, polypeptide 4) is a protein-coding gene. GO annotations related to this gene include ribosomal protein S6 kinase activity and protein serine/threonine kinase activity. An important paralog of this gene is RPS6KA6.

UniProtKB/Swiss-Prot: KS6A4_HUMAN, O75676
Function: Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of
the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that
contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes.
Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal
growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in
response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which
results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS
and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced
phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary
macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory
cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the
anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors

summary for RPS6KA4 Gene:
p90 ribosomal S6 kinases (RSKs) are a family of protein serine/threonine kinases that regulate diverse
cellular processes such as cell growth, motility, survival and proliferation. There are four isoforms of
this enzyme; RSK1-4, which are directly activated by ERK1/2 in response to growth factors, many polypeptide
hormones, neurotransmitters and chemokines. p90 RSKs phosphorylate numerous cytosolic and nuclear targets
and act as downstream effectors of the ERK/MAPK signaling cascade. They are expressed ubiquitously in human
tissues and exist in multiple subcellular compartments. Abberant activation of p90 RSKs has been linked to
many human diseases, including breast and prostate cancers.

Gene Wiki entry for RPS6KA4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPS6KA4 gene promoter:
         CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPS6KA4 promoter sequence
   Search Chromatin IP Primers for RPS6KA4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPS6KA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q11-q13   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q11-q13

RPS6KA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS6KA4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P064126:  view genomic region     (about GC identifiers)

Start:
64,126,620 bp from pter      End:
64,139,687 bp from pter
Size:
13,068 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KS6A4_HUMAN, O75676 (See protein sequence)
Recommended Name: Ribosomal protein S6 kinase alpha-4  
Size: 772 amino acids; 85606 Da
Cofactor: Magnesium
Subunit: Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells which transiently dissociates
following mitogenic stimulation. Also associates with MAPK14/p38-alpha. Activated RPS6KA4 associates with and
phosphorylates the NF-kappa-B p65 subunit RELA
Miscellaneous: Enzyme activity requires the presence of both kinase domains (By similarity)
Secondary accessions: A8K7Z8 O75585 Q53ES8
Alternative splicing: 2 isoforms:  O75676-1   O75676-2   (Ref.3 (BAD97281) sequence is in conflict in positions: 400:QQ->Q)

Explore the universe of human proteins at neXtProt for RPS6KA4: NX_O75676

Explore proteomics data for RPS6KA4 at MOPED

Post-translational modifications: 

  • Ser-343 and Thr-568 phosphorylation is required for kinase activity. Ser-343 and Ser-196 are autophosphorylated by
    the C-terminal kinase domain, and their phosphorylation is essential for the catalytic activity of the N-terminal
    kinase domain. Phosphorylated at Ser-343, Thr-568 and Thr-687 by MAPK1/ERK2, MAPK3/ERK1 and MAPK14/p38-alpha.
    Autophosphorylated at Ser-737 and Ser-745 by the N-terminal kinase domain (By similarity)1
  • Ubiquitination2 at Lys37, Lys440
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for RPS6KA4 (O75676) (see all 17)
     VVHRDLK  DLWSLGV  RDLKLEN  NFAEEFT 


    See RPS6KA4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001006945.1  NP_003933.1  

    ENSEMBL proteins: 
     ENSP00000435580   ENSP00000333896   ENSP00000435314   ENSP00000432945   ENSP00000294261  
    Reactome Protein details: O75676

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    Novus Biologicals RPS6KA4 Protein
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for RPS6KA4 

    RPS6KA4 Antibody Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: ribosomal protein S6 kinase, 90kDa, polypeptide 4
    MSK subfamily
    Other AGC kinases

    Selected InterPro protein domains (see all 8):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR000961 AGC-kinase_C
     IPR011009 Kinase-like_dom
     IPR017892 Pkinase_C

    Graphical View of Domain Structure for InterPro Entry O75676

    ProtoNet protein and cluster: O75676

    1 Blocks protein domain: IPB000961 Protein kinase C-terminal domain

    UniProtKB/Swiss-Prot: KS6A4_HUMAN, O75676
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 2 protein kinase domains


    Find genes that share domains with RPS6KA4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KS6A4_HUMAN, O75676
    Function: Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of
    the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that
    contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes.
    Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal
    growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in
    response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which
    results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS
    and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced
    phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary
    macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory
    cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the
    anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation at Ser-343, Thr-568 and Thr-687 by MAPK1/ERK2, MAPK3/ERK1 and
    MAPK14/p38-alpha, and by further autophosphorylation of Ser-196, Ser-360 and Ser-365 by the activated C-terminal
    kinase domain (By similarity)

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IMP12773393
    GO:0004711ribosomal protein S6 kinase activity NAS11035004
    GO:0004713protein tyrosine kinase activity ----
         
    Find genes that share ontologies with RPS6KA4           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for RPS6KA4:
     Decreased Hepatitis C virus re  Decreased substrate adherent c  Decreased telomerase activity  Increased cell death HMECs cel 
     Increased cell number in G2M,   Increased colony dispersion (i 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Rps6ka4):
     hematopoietic system  homeostasis/metabolism  immune system  integument  mortality/aging 
     no phenotypic analysis 

    Find genes that share phenotypes with RPS6KA4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for RPS6KA4: Rps6ka4tm1.2Gsc Rps6ka4tm1Jsca

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RPS6KA4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RPS6KA4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RPS6KA4

    miRNA
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    miRTarBase miRNAs that target RPS6KA4:
    hsa-mir-124-3p (MIRT022283)

    Block miRNA regulation of human, mouse, rat RPS6KA4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RPS6KA4 (see all 36):
    hsa-miR-142-5p hsa-miR-106a hsa-miR-25 hsa-miR-128 hsa-miR-449a hsa-miR-124 hsa-miR-9 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidRPS6KA4 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS6KA4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KS6A4_HUMAN, O75676: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0016020membrane ----

    Find genes that share ontologies with RPS6KA4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RPS6KA4 About   (see all 22)  
    See pathways by source

    SuperPathContained pathways About
    1Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    ERK5 Signaling0.61
    Cellular Apoptosis Pathway0.85
    2L1CAM interactions
    Axon guidance0.63
    L1CAM interactions0.36
    Developmental Biology0.63
    3ERK Signaling
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    4CNTF Signaling
    CNTF Signaling0.50
    FLT3 Signaling0.50
    5Development EGFR signaling pathway
    GDNF-Family Ligands and Receptor Interactions0.41
    BDNF Pathway0.39


    Find genes that share SuperPaths with RPS6KA4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RPS6KA4 (see all 18)
        FLT3 Signaling
    MAPK Signaling
    Mitochondrial Apoptosis
    CNTF Signaling
    GDNF-Family Ligands and Receptor Interactions

    1 Cell Signaling Technology (CST) Pathway for RPS6KA4
        MAP Kinase Signaling

    1 GeneGo (Thomson Reuters) Pathway for RPS6KA4
        Transcription CREB pathway

    4 BioSystems Pathways for RPS6KA4
        Insulin Signaling
    Interferon type I
    Signaling mediated by p38-alpha and p38-beta
    ErbB1 downstream signaling

    1 Reactome Pathway for RPS6KA4
        Recycling pathway of L1


    2 Kegg Pathways  (Kegg details for RPS6KA4):
        MAPK signaling pathway
    TNF signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RPS6KA4
    Interactions:

        GeneGlobe Interaction Network for RPS6KA4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPS6KA4 (O756761, 2, 3 ENSP000003338964) via UniProtKB, MINT, STRING, and/or I2D (see all 824)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK14Q165391, 3, ENSP000002297944EBI-73933,EBI-73946 I2D: score=5 STRING: ENSP00000229794
    CDC5LQ994592, ENSP000003605324MINT-7945693 MINT-7947479 STRING: ENSP00000360532
    HNRNPKP619782, ENSP000003654394MINT-7945693 MINT-7947479 STRING: ENSP00000365439
    SNW1Q135732, ENSP000002615314MINT-7945693 MINT-7947479 STRING: ENSP00000261531
    MAPK3P273613, ENSP000002630254I2D: score=4 STRING: ENSP00000263025
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001818negative regulation of cytokine production TAS18508628
    GO:0006355regulation of transcription, DNA-templated IDA9792677
    GO:0006468protein phosphorylation IDA9792677
    GO:0006954inflammatory response IEA--
    GO:0007411axon guidance TAS--

    Find genes that share ontologies with RPS6KA4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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      Browse compounds at ApexBio 

    Compounds for RPS6KA4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BRD 7389p90 ribosomal S6 kinase inhibitor[376382-11-5]
    PF 4708671S6K1 inhibitor[1255517-76-0]
    SL 0101-1Selective p90 ribosomal S6 kinase (RSK) inhibitor[77307-50-7]

    3 HMDB Compounds for RPS6KA4    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    1 DrugBank Compound for RPS6KA4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Riboflavin Monophosphate-- 146-17-8target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RPS6KA4 gene (2 alternative transcripts): 
    NM_001006944.1  NM_003942.2  

    Unigene Cluster for RPS6KA4:

    Ribosomal protein S6 kinase, 90kDa, polypeptide 4
    Hs.105584  [show with all ESTs]
    Unigene Representative Sequence: AK223561
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000528057(uc001oad.3 uc001oaf.3 uc009ypp.3) ENST00000334205(uc001oae.3 uc010rnl.2)
    ENST00000530383 ENST00000531659 ENST00000528355 ENST00000530504 ENST00000532885
    ENST00000532496 ENST00000294261
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    hsa-miR-142-5p hsa-miR-106a hsa-miR-25 hsa-miR-128 hsa-miR-449a hsa-miR-124 hsa-miR-9 hsa-miR-93
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    GenScript: all cDNA clones in your preferred vector (see all 2): RPS6KA4 (NM_003942)
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      QuantiFast Probe-based Assays in human, mouse, rat RPS6KA4

    Additional mRNA sequence: 

    AF074715.1 AJ010119.1 AK223561.1 AK292163.1 AK298507.1 AK313567.1 BC020451.1 BC028079.1 
    BC047896.1 

    8 DOTS entries:

    DT.100790145  DT.100790148  DT.109906  DT.120759337  DT.91811346  DT.120759355  DT.97787978  DT.97846016 

    Selected AceView cDNA sequences (see all 94):

    BX342041 BE464227 BC028079 BF939389 BQ944046 BC020451 BM549708 BQ685225 
    BM554101 BX117193 BI333223 BM854610 BE279481 AI368905 BM806024 AI870169 
    BI871330 BU502469 AI284115 CA455124 BM504503 BM544719 AI247135 BC047896 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RPS6KA4 (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b
    SP1:              -                       -     -                                                                                                               
    SP2:              -                       -     -                                                     -                                                         
    SP3:              -                       -     -                                                     -                                                         
    SP4:              -                       -     -                                               -     -     -     -     -     -     -                           
    SP5:              -           -     -     -     -                                                                                                               


    ECgene alternative splicing isoforms for RPS6KA4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RPS6KA4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCACTGCCT
    RPS6KA4 Expression
    About this image


    RPS6KA4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
    RPS6KA4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPS6KA4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.105584
        Custom PCR Arrays for RPS6KA4
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPS6KA4 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rps6ka41 , 5 ribosomal protein S6 kinase, polypeptide 41, 5 88.17(n)1
    96.11(a)1
      19 (5.08 cM)5
    566131  NM_019924.21  NP_064308.21 
     68290855 
    lizard
    (Anolis carolinensis)
    Reptilia RPS6KA46
    ribosomal protein S6 kinase, 90kDa, polypeptide 4
    75(a)
    1 ↔ 1
    GL343739.1(26300-169037)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004869731 ribosomal protein S6 kinase alpha-5-like 62.98(n)
    68.13(a)
      100486973  XM_004919208.1  XP_004919265.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rps6ka41 ribosomal protein S6 kinase, polypeptide 4 67.72(n)
    72.18(a)
      561959  NM_001126403.1  NP_001119875.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta JIL-16
    JIL-1
    26(a)
    1 → many
    3L(11071852-11086293)
    worm
    (Caenorhabditis elegans)
    Secernentea C54G4.13 Protein kinase C terminal domain 47(a)
    (best of 2)
      I(8022529-8027132)   --
    rice
    (Oryza sativa)
    Liliopsida NM_197757.12   -- 76.38(n)    NM_197757.1 


    ENSEMBL Gene Tree for RPS6KA4 (if available)
    TreeFam Gene Tree for RPS6KA4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RPS6KA4 gene
    RPS6KA62  MAPKAPK32  MAPKAPK52  RPS6KA12  RPS6KA52  MAPKAPK22  MKNK12  MKNK22  
    RPS6KA32  RPS6KA22  
    Selected SIMAP similar genes for RPS6KA4 using alignment to 5 protein entries:     KS6A4_HUMAN (see all proteins) (see all similar genes):
    RPS6KA5    KIN27    PRKY    PRKACB    PRKCE    RPS6KB2
    RPS6KA2    DAPK1    DAPK3    PRKACA    STK17B    RPS6KB1
    AKT3    CAMK1G    RPS6KA3    DKFZp586C1419    MARK4    NUAK1

    Find genes that share paralogs with RPS6KA4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RPS6KA4 (see all 302)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0406324
    A breast infiltrating ductal carcinoma sample4--see VAR_0406322 S L mis40--------
    rs749433591,2
    C,F--64125588(+) GCAGAG/ACTGGG 2 -- us2k12Minor allele frequency- A:0.14WA 120
    rs1168635721,2
    F--64125599(+) AGGGAC/TGGTCC 2 -- us2k11Minor allele frequency- T:0.01EA 120
    rs3739658741,2
    C--64125604(+) CGGTCC/TTCCGG 2 -- us2k10--------
    rs37590571,2
    C--64125680(-) CCCCAC/TGCCCC 2 -- us2k13Minor allele frequency- T:0.13NA EA 242
    rs1178085551,2
    F--64125764(+) TGGCTG/ATCCCA 2 -- us2k11Minor allele frequency- A:0.02NA 120
    rs1890461171,2
    --64125858(+) GGGCCC/TTGGGC 2 -- us2k10--------
    rs1416114891,2
    --64125866(+) GGCCTC/TATGGG 2 -- us2k10--------
    rs1505119541,2
    C--64125940(+) GGGTAC/GTGCAC 2 -- us2k10--------
    rs5002651,2
    C,F,A--64126040(+) CAGGCC/ACCCCC 2 -- us2k114Minor allele frequency- A:0.11EA NA WA CSA 427

    HapMap Linkage Disequilibrium report for RPS6KA4 (64126620 - 64139687 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for RPS6KA4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv358CNV Insertion18451855
    nsv832187CNV Loss17160897
    dgv1169n71CNV Loss21882294
    nsv897685CNV Loss21882294
    dgv1166n71CNV Loss21882294
    dgv1156n71CNV Loss21882294
    dgv1170n71CNV Loss21882294
    dgv13n64CNV Loss17921354
    nsv832186CNV Loss17160897
    dgv1163n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603606    OMIM disorders: --


    Find genes that share disorders with RPS6KA4           About GenesLikeMe

    Genetic Association Database (GAD): RPS6KA4
    Human Genome Epidemiology (HuGE) Navigator: RPS6KA4 (2 documents)

    Export disorders for RPS6KA4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RPS6KA4 gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with RPS6KA4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK). (PubMed id 9792677)1, 2, 3 Pierrat B.... Lesslauer W. (J. Biol. Chem. 1998)
    2. Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. (PubMed id 9687510)1, 2, 3 Deak M.... Alessi D.R. (EMBO J. 1998)
    3. Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients. (PubMed id 20805296)1, 4 Coulthard L.R....McDermott M.F. (Ann. Rheum. Dis. 2011)
    4. Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy. (PubMed id 22019778)1, 4 Zhang F....Zhang X. (Nat. Genet. 2011)
    5. Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis. (PubMed id 21399635)1, 4 Mells G.F....Anderson C.A. (Nat. Genet. 2011)
    6. MSK activation and physiological roles. (PubMed id 18508628)1, 2 Arthur J.S. (Front. Biosci. 2008)
    7. MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14. (PubMed id 12773393)1, 2 Soloaga A.... Arthur J.S. (EMBO J. 2003)
    8. C-terminal elements control location, activation threshold, and p38 docking of ribosomal S6 kinase B (RSKB). (PubMed id 11035004)1, 2 Tomas-Zuber M.... Lesslauer W. (J. Biol. Chem. 2001)
    9. Differential regulation of mitogen- and stress-activated protein kinase-1 and -2 (MSK1 and MSK2) by CK2 following UV radiation. (PubMed id 19933278)1, 9 Jacks K.A. and Koch C.A. (J. Biol. Chem. 2010)
    10. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8986 HGNC: 10433 AceView: RPS6KA4 Ensembl:ENSG00000162302 euGenes: HUgn8986
    ECgene: RPS6KA4 Kegg: 8986 H-InvDB: RPS6KA4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RPS6KA4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RPS6KA4 gene:
    Search GeneIP for patents involving RPS6KA4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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