RPS6KA4 Gene
protein-coding GIFtS: 65
GCID: GC11P064126
|
|
ribosomal protein S6 kinase, 90kDa, polypeptide 4(Previous names: ribosomal protein S6 kinase, 90kD, polypeptide 4 )
| |
Aliases
for RPS6KA4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 41 2 | | S6K-Alpha-41 | | MSK21 2 3 | | EC 2.7.11.13 8 | | RSK-B1 2 | | Ribosomal Protein S6 Kinase, 90kD, Polypeptide 41 | | Nuclear Mitogen- And Stress-Activated Protein Kinase 22 3 | | Mitogen- And Stress-Activated Protein Kinase 22 | | Ribosomal Protein Kinase B2 3 | | Ribosomal Protein S6 Kinase Alpha 42 | | 90 KDa Ribosomal Protein S6 Kinase 42 3 | | Ribosomal Protein S6 Kinase Alpha-42 | | RSKB2 3 | | EC 2.7.118 |
Export aliases for RPS6KA4 gene to outside databasesPrevious GC identifers: GC11P066642 GC11P065808 GC11P064377 GC11P063902 GC11P063884 GC11P060454 |
Summaries
for RPS6KA4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RPS6KA4:
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-fos. Alternatetranscriptional splice variants of this gene have been observed but have not been thoroughly characterized. (providedby RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: KS6A4_HUMAN, O75676Function: Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of thetranscription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes togene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) andanisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptionalactivation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1(HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 tolimit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinasephosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors
 summary
for RPS6KA4: p90 ribosomal S6 kinases (RSKs) are a family of protein serine/threonine kinases that regulate diverse
cellular processes such as cell growth, motility, survival and proliferation. There are four isoforms of
this enzyme; RSK1-4, which are directly activated by ERK1/2 in response to growth factors, many polypeptide
hormones, neurotransmitters and chemokines. p90 RSKs phosphorylate numerous cytosolic and nuclear targets
and act as downstream effectors of the ERK/MAPK signaling cascade. They are expressed ubiquitously in human
tissues and exist in multiple subcellular compartments. Abberant activation of p90 RSKs has been linked to
many human diseases, including breast and prostate cancers.
Gene Wiki entry for RPS6KA4
|
Genomic Views
for RPS6KA4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RPS6KA4 gene promoter:
CREB deltaCREB
Other transcription factors
Search SABiosciences Chromatin IP Primers for RPS6KA4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS6KA4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q11-q13 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q11-q13RPS6KA4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P064126: view genomic region
(about GC identifiers)
Start:
|
64,126,620 bp from pter |
End:
|
64,139,687 bp from pter |
Size:
|
13,068 bases |
Orientation:
|
plus strand |
|
Proteins
for RPS6KA4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KS6A4_HUMAN, O75676 (See
protein sequence)Recommended Name: Ribosomal protein S6 kinase alpha-4 Size: 772 amino acids; 85606 Da
Cofactor: Magnesium
Subunit: Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells which transiently dissociatesfollowing mitogenic stimulation. Also associates with MAPK14/p38-alpha. Activated RPS6KA4 associates with andphosphorylates the NF-kappa-B p65 subunit RELA
Subcellular location: Nucleus
Miscellaneous: Enzyme activity requires the presence of both kinase domains (By similarity)
Secondary accessions: A8K7Z8 O75585 Q53ES8Alternative splicing: 2 isoforms: O75676-1 O75676-2 (Ref.3 (BAD97281) sequence is in conflict in positions: 400:QQ->Q)Explore the universe of human proteins at neXtProt for RPS6KA4: NX_O75676
Post-translational modifications:
Ser-343 and Thr-568 phosphorylation is required for kinase activity. Ser-343 and Ser-196 are autophosphorylated by theC-terminal kinase domain, and their phosphorylation is essential for the catalytic activity of the N-terminal kinasedomain. Phosphorylated at Ser-343, Thr-568 and Thr-687 by MAPK1/ERK2, MAPK3/ERK1 and MAPK14/p38-alpha.Autophosphorylated at Ser-737 and Ser-745 by the N-terminal kinase domain (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75676
4/17 DME Specific Peptides for RPS6KA4 (O75676) (see all 17)
RPS6KA4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001006945.1 NP_003933.1
ENSEMBL proteins: ENSP00000435580 ENSP00000333896 ENSP00000435314 ENSP00000432945 ENSP00000294261 Reactome Protein details: O75676
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
RPS6KA4 for ontologies About GeneDecksing
RPS6KA4 Antibody Products:
Assay Products for RPS6KA4: |
Protein
Domains /
Families
for RPS6KA4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RPS6KA4 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry O75676ProtoNet protein and cluster: O75676 1 Blocks protein family: IPB000961 Protein kinase C-terminal domain
UniProtKB/Swiss-Prot: KS6A4_HUMAN, O75676Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamilySimilarity: Contains 1 AGC-kinase C-terminal domainSimilarity: Contains 2 protein kinase domains |
Function
for RPS6KA4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KS6A4_HUMAN, O75676Function: Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of thetranscription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes togene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) andanisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptionalactivation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1(HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 tolimit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinasephosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factorsCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Activated by phosphorylation at Ser-343, Thr-568 and Thr-687 by MAPK1/ERK2, MAPK3/ERK1 andMAPK14/p38-alpha, and by further autophosphorylation of Ser-196, Ser-360 and Ser-365 by the activated C-terminalkinase domain (By similarity)Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPS6KA4 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPS6KA4 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): RPS6KA4 (NM_003942) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPS6KA4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS6KA4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS6KA4 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
RPS6KA4 for ontologies About GeneDecksing
6 GenomeRNAi human phenotypes for RPS6KA4:
Animal Models:
Mouse knock-outs for RPS6KA4: Rps6ka4tm1.2Gsc Rps6ka4tm1Jsca
7 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Rps6ka4):
RPS6KA4 for phenotypes About GeneDecksing
|
Pathways & Interactions
for RPS6KA4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Axon guidance | | | 2 | Apoptotic Pathways in Synovial Fibroblasts | | | 3 | Rho Family GTPases | | | 4 | Transcription CREB pathway | | | 5 | CNTF Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for RPS6KA4
5/18 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RPS6KA4 (see all 18)
1 
Cell Signaling Technology (CST) Pathway for RPS6KA4
1  GeneGo (Thomson Reuters) Pathway for RPS6KA4
3  BioSystems Pathways for RPS6KA4
5 
Reactome Pathways for RPS6KA4
2 
Kegg Pathways (Kegg details for RPS6KA4):
RPS6KA4 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RPS6KA4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/769 Interacting proteins for RPS6KA4 (O756761, 2, 3 ENSP000003338964) via UniProtKB, MINT, STRING, and/or I2D (see all 769)About this table
Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table
RPS6KA4 for ontologies About GeneDecksing
|
Drugs & Compounds
for RPS6KA4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Compounds for RPS6KA4 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| SL 0101-1 | Selective p90 ribosomal S6 kinase (RSK) inhibitor | [77307-50-7] |
3 HMDB Compounds for RPS6KA4 About this table
1 DrugBank Compound for RPS6KA4 About this table
Search CenterWatch for drugs/clinical trials and news about RPS6KA4 / KS6A4
|
Transcripts
for RPS6KA4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RPS6KA4 gene (2 alternative transcripts): NM_001006944.1 NM_003942.2 Unigene Cluster for RPS6KA4: Ribosomal protein S6 kinase, 90kDa, polypeptide 4 Hs.105584 [show with all ESTs]Unigene Representative Sequence: AK2235619 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000528057(uc001oad.3 uc001oaf.3 uc009ypp.3) ENST00000334205(uc001oae.3 uc010rnl.2)
ENST00000530383 ENST00000531659 ENST00000528355 ENST00000530504 ENST00000532885
ENST00000532496 ENST00000294261
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPS6KA4 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPS6KA4 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): RPS6KA4 (NM_003942) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPS6KA4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS6KA4 |
Additional cDNA sequence: AF074715.1 AJ010119.1 AK223561.1 AK292163.1 AK298507.1 AK313567.1 BC020451.1 BC028079.1 BC047896.1 8 DOTS entries: DT.100790145 DT.100790148 DT.109906 DT.120759337 DT.91811346 DT.120759355 DT.97787978 DT.97846016 24/94 AceView cDNA sequences (see all 94): BF939389 BC028079 BX342041 BM549708 BQ685225 BE464227 BQ944046 BC020451 BM554101 BG437505 BM543492 AI368905 BI259322 BM850236 BE279481 BM048291 H53714 BM504503 BC047896 BM806024 BI871330 AI924408 BM544719 BI770949
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for RPS6KA4 (see all 9) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17a | · | 17b |
|---|
|
| SP1: | | | | | - | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | | | | | | | - | | - | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | |
| SP5: | | | | | - | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RPS6KA4
|
Expression
for RPS6KA4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RPS6KA4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTCACTGCCT
About this image
See RPS6KA4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RPS6KA4
SOURCE GeneReport for Unigene cluster: Hs.105584
SABiosciences Custom PCR Arrays for RPS6KA4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPS6KA4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RPS6KA4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS6KA4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS6KA4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS6KA4 |
Orthologs
for RPS6KA4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RPS6KA4 gene from 6/25 species (see all 25) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
RPS6KA46 |
-- |
75(a) |
1 ↔ 1 |
GL343739.1(26300-49386) |
zebrafish
(Danio rerio) |
Actinopterygii |
rps6ka41 |
ribosomal protein S6 kinase, polypeptide 4 |
67.63(n)
72.31(a) |
|
561959 NM_001126403.1 NP_001119875.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
JIL-16 |
JIL-1 |
15(a) |
1 → many |
3L(11071852-11086293) |
worm
(Caenorhabditis elegans) |
Secernentea |
C54G4.13 |
Protein kinase C terminal domain |
47(a)
(best of 2) |
|
I(8022529-8027132) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
S6K26ATPK16 |
serine/threonine-protein kinase AtPK1/AtPK6 |
31(a)31(a) |
many ↔ manymany ↔ many |
3(2648509-2651160) 3(2651447-2654212) |
rice
(Oryza sativa) |
Liliopsida |
NM_197757.12 |
-- |
76.38(n) |
|
NM_197757.1 |
ENSEMBL Gene Tree for RPS6KA4 (if available)
TreeFam Gene Tree for RPS6KA4 (if available) |
Paralogs
for RPS6KA4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RPS6KA4 gene
- AKT12 RPS6KA62 RPS6KB12 SGK32 SGK22 RPS6KA12 AKT32 RPS6KA52
- SGK12 RPS6KB22 RPS6KA22 AKT22 RPS6KA32
18/89 SIMAP similar genes for RPS6KA4 using alignment to 5 protein entries: KS6A4_HUMAN (see all proteins)
(see all similar genes):RPS6KA5 KIN27 PRKY PRKACB PRKCE RPS6KB2
RPS6KA2 DAPK1 PRKACA RPS6KB1 AKT3 CAMK1G
RPS6KA3 DKFZp586C1419 MARK4 NUAK1 SGK2 PRKX
RPS6KA4 for paralogs About GeneDecksing
|
Genomic Variants
for RPS6KA4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RPS6KA4 (64126620 - 64139687 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RPS6KA4
1 CNV: 10364 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPS6KA4 |
|
Disorders
/ Diseases
for RPS6KA4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RPS6KA4 for disorders About GeneDecksing
OMIM gene information: 603606
OMIM disorders: --
7  diseases for RPS6KA4: About MalaCardsprostate cancer prostatitis primary biliary cirrhosis rheumatoid arthritis
arthritis leprosy alcoholism
Human Genome Epidemiology (HuGE) Navigator: RPS6KA4 (2 documents)
Export disorders for RPS6KA4 gene to outside databases
|
Publications
for RPS6KA4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RPS6KA4 gene, integrated from 9 sources (see all 39):
(articles sorted by number of sources associating them with RPS6KA4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK). (PubMed id 9792677)1, 2, 3 Pierrat B.... Lesslauer W. (1998)
- Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. (PubMed id 9687510)1, 2, 3 Deak M.... Alessi D.R. (1998)
- MSK activation and physiological roles. (PubMed id 18508628)1, 2 Arthur J.S. (2008)
- MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14. (PubMed id 12773393)1, 2 Soloaga A.... Arthur J.S. (2003)
- C-terminal elements control location, activation threshold, and p38 docking of ribosomal S6 kinase B (RSKB). (PubMed id 11035004)1, 2 Tomas-Zuber M....Lesslauer W. (2001)
- Differential regulation of mitogen- and stress-activa ted protein kinase-1 and -2 (MSK1 and MSK2) by CK2 following UV radiation. (PubMed id 19933278)1, 9 Jacks K.A. and Koch C.A. (2010)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Genetic variants within the MAP kinase signalling net work and anti-TNF treatment response in rheumatoid arthritis patients. (PubMed id 20805296)1 Coulthard L.R....McDermott M.F. (2011)
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External Searches for RPS6KA4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing RPS6KA4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing RPS6KA4 gene
(According to HUGE)
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Specialized Databases showing RPS6KA4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for RPS6KA4 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for RPS6KA4 gene:
Search GeneIP for patents involving RPS6KA4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for RPS6KA4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RPS6KA4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPS6KA4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPS6KA4 | | | OriGene Protein Over-expression Lysate for RPS6KA4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RPS6KA4 | | OriGene 3'-UTR Clone for RPS6KA4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPS6KA4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPS6KA4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RPS6KA4 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RPS6KA4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPS6KA4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS6KA4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS6KA4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS6KA4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS6KA4 |
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| | Antibodies & Assays for RPS6KA4 (MSK2) |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS6KA4 |
|  |  |  | | | | ThermoFisher Antibodies for RPS6KA4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS6KA4 |
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