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Aliases for RPS6KA3 Gene

Aliases for RPS6KA3 Gene

  • Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 2 3
  • RSK2 3 4 6
  • MAP Kinase-Activated Protein Kinase 1b 3 4
  • Insulin-Stimulated Protein Kinase 1 3 4
  • MAPK-Activated Protein Kinase 1b 3 4
  • Ribosomal S6 Kinase 2 3 4
  • MAPKAP Kinase 1b 3 4
  • S6K-Alpha-3 3 4
  • EC 2.7.11.1 4 64
  • MAPKAPK-1b 3 4
  • P90-RSK 3 3 4
  • MAPKAPK1B 3 4
  • Pp90RSK2 3 4
  • ISPK-1 3 4
  • MRX19 3 6
  • RSK-2 3 4
  • Ribosomal Protein S6 Kinase, 90kD, Polypeptide 3 2
  • 90 KDa Ribosomal Protein S6 Kinase 3 4
  • Ribosomal Protein S6 Kinase Alpha-3 3
  • Mental Retardation, X-Linked 19 2
  • Coffin-Lowry Syndrome 2
  • S6K-Alpha3 3
  • EC 2.7.11 64
  • P90-RSK2 3
  • P90RSK3 4
  • ISPK1 4
  • HU-3 3
  • CLS 3
  • RSK 3

External Ids for RPS6KA3 Gene

Previous Symbols for RPS6KA3 Gene

  • MRX19
  • CLS

Summaries for RPS6KA3 Gene

Entrez Gene Summary for RPS6KA3 Gene

  • This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS6KA3 Gene

RPS6KA3 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3) is a Protein Coding gene. Diseases associated with RPS6KA3 include coffin-lowry syndrome and alpha-thalassemia/mental retardation syndrome. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include protein serine/threonine kinase activity and magnesium ion binding. An important paralog of this gene is MKNK2.

UniProtKB/Swiss-Prot for RPS6KA3 Gene

  • Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at Ser-10, which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at Ser-9 and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex. In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at Ser-1798, which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression. In LPS-stimulated dendritic cells, is involved in TLR4-induced macropinocytosis, and in myeloma cells, acts as effector of FGFR3-mediated transformation signaling, after direct phosphorylation at Tyr-529 by FGFR3. Phosphorylates DAPK1.

Tocris Summary for RPS6KA3 Gene

  • p90 ribosomal S6 kinases (RSKs) are a family of protein serine/threonine kinases that regulate diverse cellular processes such as cell growth, motility, survival and proliferation. There are four isoforms of this enzyme; RSK1-4, which are directly activated by ERK1/2 in response to growth factors, many polypeptide hormones, neurotransmitters and chemokines. p90 RSKs phosphorylate numerous cytosolic and nuclear targets and act as downstream effectors of the ERK/MAPK signaling cascade. They are expressed ubiquitously in human tissues and exist in multiple subcellular compartments. Abberant activation of p90 RSKs has been linked to many human diseases, including breast and prostate cancers.

Gene Wiki entry for RPS6KA3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS6KA3 Gene

Genomics for RPS6KA3 Gene

Genomic Location for RPS6KA3 Gene

Start:
20,149,911 bp from pter
End:
20,267,100 bp from pter
Size:
117,190 bases
Orientation:
Minus strand

Genomic View for RPS6KA3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPS6KA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS6KA3 Gene

Regulatory Elements for RPS6KA3 Gene

Proteins for RPS6KA3 Gene

  • Protein details for RPS6KA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51812-KS6A3_HUMAN
    Recommended name:
    Ribosomal protein S6 kinase alpha-3
    Protein Accession:
    P51812
    Secondary Accessions:
    • B2R9V4
    • Q4VAP3
    • Q59H26
    • Q5JPK8
    • Q7Z3Z7

    Protein attributes for RPS6KA3 Gene

    Size:
    740 amino acids
    Molecular mass:
    83736 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells. Transiently dissociates following mitogenic stimulation (By similarity). Interacts with NFATC4, ETV1/ER81 and FGFR1.
    SequenceCaution:
    • Sequence=BAD92170.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPS6KA3 Gene

neXtProt entry for RPS6KA3 Gene

Proteomics data for RPS6KA3 Gene at MOPED

Post-translational modifications for RPS6KA3 Gene

  • Activated by phosphorylation at Ser-227 by PDPK1. Autophosphorylated on Ser-386, as part of the activation process. May be phosphorylated at Thr-365 and Ser-369 by MAPK1/ERK2 and MAPK3/ERK1. Can also be activated via phosphorylation at Ser-386 by MAPKAPK2
  • N-terminal myristoylation results in an activated kinase in the absence of added growth factors
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys72, Lys81, Lys504, Lys566, Lys591, and Lys658

Other Protein References for RPS6KA3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for RPS6KA3 Gene

UniProtKB/Swiss-Prot:

KS6A3_HUMAN
Domain:
  • Contains 1 AGC-kinase C-terminal domain.:
    • P51812
  • Contains 2 protein kinase domains.:
    • P51812
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.:
    • P51812
genes like me logo Genes that share domains with RPS6KA3: view

Function for RPS6KA3 Gene

Molecular function for RPS6KA3 Gene

GENATLAS Biochemistry: ribosomal S6 kinase,polypeptide 3,growth factor regulated serine /threonine kinase family,responsive for the activation of glycogen synthesis,involved in cell proliferation and differentiation but not in vivo in the phosphorylation of RPS6,mediating protein synthesis initiation and elongation induced by hormones or growth factors,maybe playing an essentilal regulatory role in protein synthesis during cell proliferation,required for epidermal growth factor activated phosphorylation of histone H3
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Upon extracellular signal or mitogen stimulation, phosphorylated at Thr-577 in the C-terminal kinase domain (CTKD) by MAPK1/ERK2 and MAPK3/ERK1. The activated CTKD then autophosphorylates Ser-386, allowing binding of PDPK1, which in turn phosphorylates Ser-227 in the N-terminal kinase domain (NTDK) leading to the full activation of the protein and subsequent phosphorylation of the substrates by the NTKD
UniProtKB/Swiss-Prot Function: Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at Ser-10, which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at Ser-9 and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex. In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at Ser-1798, which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression. In LPS-stimulated dendritic cells, is involved in TLR4-induced macropinocytosis, and in myeloma cells, acts as effector of FGFR3-mediated transformation signaling, after direct phosphorylation at Tyr-529 by FGFR3. Phosphorylates DAPK1.

Enzyme Numbers (IUBMB) for RPS6KA3 Gene

Gene Ontology (GO) - Molecular Function for RPS6KA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0004672 protein kinase activity TAS 10436156
GO:0004674 protein serine/threonine kinase activity TAS 8141249
GO:0004711 ribosomal protein S6 kinase activity IBA --
GO:0004713 protein tyrosine kinase activity --
genes like me logo Genes that share ontologies with RPS6KA3: view
genes like me logo Genes that share phenotypes with RPS6KA3: view

Animal Models for RPS6KA3 Gene

MGI Knock Outs for RPS6KA3:

No data available for Transcription Factor Targeting and HOMER Transcription for RPS6KA3 Gene

Localization for RPS6KA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS6KA3 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS6KA3 Gene COMPARTMENTS Subcellular localization image for RPS6KA3 gene
Compartment Confidence
cytosol 4
nucleus 4
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPS6KA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with RPS6KA3: view

Pathways for RPS6KA3 Gene

genes like me logo Genes that share pathways with RPS6KA3: view

Gene Ontology (GO) - Biological Process for RPS6KA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS 8955270
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0006468 protein phosphorylation IBA --
genes like me logo Genes that share ontologies with RPS6KA3: view

Compounds for RPS6KA3 Gene

(3) Tocris Compounds for RPS6KA3 Gene

Compound Action Cas Number
BRD 7389 p90 ribosomal S6 kinase inhibitor [376382-11-5]
PF 4708671 S6K1 inhibitor [1255517-76-0]
SL 0101-1 Selective p90 ribosomal S6 kinase (RSK) inhibitor [77307-50-7]

(3) HMDB Compounds for RPS6KA3 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4

(14) Novoseek inferred chemical compound relationships for RPS6KA3 Gene

Compound -log(P) Hits PubMed IDs
threonine 62.3 16
serine 50.6 16
rapamycin 40.3 3
wortmannin 33 1
pd 98,059 32.9 1
genes like me logo Genes that share compounds with RPS6KA3: view

Transcripts for RPS6KA3 Gene

Unigene Clusters for RPS6KA3 Gene

Ribosomal protein S6 kinase, 90kDa, polypeptide 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPS6KA3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b
SP1: - - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for RPS6KA3 Gene

GeneLoc Exon Structure for
RPS6KA3
ECgene alternative splicing isoforms for
RPS6KA3

Expression for RPS6KA3 Gene

mRNA expression in normal human tissues for RPS6KA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RPS6KA3 Gene

This gene is overexpressed in Muscle - Skeletal (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS6KA3 Gene

SOURCE GeneReport for Unigene cluster for RPS6KA3 Gene Hs.445387

mRNA Expression by UniProt/SwissProt for RPS6KA3 Gene

P51812-KS6A3_HUMAN
Tissue specificity: Expressed in many tissues, highest levels in skeletal muscle
genes like me logo Genes that share expressions with RPS6KA3: view

Orthologs for RPS6KA3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS6KA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPS6KA3 36
  • 96.66 (n)
  • 96.07 (a)
cow
(Bos Taurus)
Mammalia RPS6KA3 36
  • 95.77 (n)
  • 99.86 (a)
RPS6KA3 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPS6KA3 36
  • 95.93 (n)
  • 99.86 (a)
RPS6KA3 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rps6ka3 36
  • 94.41 (n)
  • 99.86 (a)
Rps6ka3 16
Rps6ka3 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RPS6KA3 37
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPS6KA3 37
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rps6ka3 36
  • 94.95 (n)
  • 99.73 (a)
chicken
(Gallus gallus)
Aves RPS6KA3 36
  • 86.43 (n)
  • 96.81 (a)
RPS6KA3 37
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPS6KA3 37
  • 97 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.33175 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496161 36
  • 79.63 (n)
  • 91.52 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.21039 36
rps6ka3a 37
  • 86 (a)
OneToMany
rps6ka3b 36
  • 73.83 (n)
  • 85.63 (a)
rps6ka3b 37
  • 86 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003040 36
  • 59.08 (n)
  • 67.06 (a)
fruit fly
(Drosophila melanogaster)
Insecta S6kII 36
  • 57.85 (n)
  • 63.08 (a)
S6kII 37
  • 48 (a)
OneToMany
Pk17E 38
  • 42 (a)
S6kII 38
  • 57 (a)
worm
(Caenorhabditis elegans)
Secernentea rskn-1 37
  • 56 (a)
OneToMany
F28C10.3 38
  • 36 (a)
T01H8.1b 38
  • 62 (a)
R04A9.5 38
  • 41 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.5313 36
soybean
(Glycine max)
eudicotyledons Gma.3835 36
barley
(Hordeum vulgare)
Liliopsida Hv.12219 36
rice
(Oryza sativa)
Liliopsida Os.11068 36
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8096 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 71 (a)
OneToMany
Species with no ortholog for RPS6KA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS6KA3 Gene

ENSEMBL:
Gene Tree for RPS6KA3 (if available)
TreeFam:
Gene Tree for RPS6KA3 (if available)

Paralogs for RPS6KA3 Gene

genes like me logo Genes that share paralogs with RPS6KA3: view

Variants for RPS6KA3 Gene

Sequence variations from dbSNP and Humsavar for RPS6KA3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1136247 -- 20,154,468(-) TTGCC(A/C)ATATA utr-variant-3-prime, intron-variant
rs2230488 other 20,186,343(-) ACACT(A/C)CCTTT synonymous-codon, reference
rs4075126 -- 20,164,677(-) CAGGG(C/T)ATGGT intron-variant
rs4078459 -- 20,206,450(+) ATTAT(A/G)TGCTT intron-variant
rs4129870 -- 20,207,212(-) cagta(A/G)agatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPS6KA3 Gene

Variant ID Type Subtype PubMed ID
nsv526033 CNV Gain 19592680
nsv520690 CNV Gain 19592680
esv2672797 CNV Deletion 23128226

Relevant External Links for RPS6KA3 Gene

HapMap Linkage Disequilibrium report
RPS6KA3
Human Gene Mutation Database (HGMD)
RPS6KA3
Locus Specific Mutation Databases (LSDB)
RPS6KA3

Disorders for RPS6KA3 Gene

(2) OMIM Diseases for RPS6KA3 Gene (300075)

UniProtKB/Swiss-Prot

KS6A3_HUMAN
  • Coffin-Lowry syndrome (CLS) [MIM:303600]: A X-linked mental retardation associated with facial and digital dysmorphisms, progressive skeletal malformations, growth retardation, hearing deficit and paroxysmal movement disorders. {ECO:0000269 PubMed:10094187, ECO:0000269 PubMed:10528858, ECO:0000269 PubMed:14986828, ECO:0000269 PubMed:15214012, ECO:0000269 PubMed:8955270, ECO:0000269 PubMed:9837815}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Mental retardation, X-linked 19 (MRX19) [MIM:300844]: A non-syndromic form of mild to moderate mental retardation. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. In contrast to syndromic or specific X-linked mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation. {ECO:0000269 PubMed:10319851, ECO:0000269 PubMed:17100996}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for RPS6KA3 Gene

(9) Novoseek inferred disease relationships for RPS6KA3 Gene

Disease -log(P) Hits PubMed IDs
coffin-lowry syndrome 98.2 46
mental retardation 64.2 9
severe mental retardation 62.9 1
cancer 3.63 9
shock 0 2

Relevant External Links for RPS6KA3

GeneTests
RPS6KA3
GeneReviews
RPS6KA3
Genetic Association Database (GAD)
RPS6KA3
Human Genome Epidemiology (HuGE) Navigator
RPS6KA3
genes like me logo Genes that share disorders with RPS6KA3: view

Publications for RPS6KA3 Gene

  1. Human rsk isoforms: cloning and characterization of tissue-specific expression. (PMID: 8141249) Moller D.E. … Jakubowski M. (Am. J. Physiol. 1994) 2 3 4 23
  2. Mutations in the kinase Rsk-2 associated with Coffin-Lowry syndrome. (PMID: 8955270) Trivier E. … Hanauer A. (Nature 1996) 3 4 23 49
  3. Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene. (PMID: 9770464) De Cesare D. … Sassone-Corsi P. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 4 23
  4. Mutation analysis of the RSK2 gene in Coffin-Lowry patients: extensive allelic heterogeneity and a high rate of De novo mutations. (PMID: 9837815) Jacquot S. … Hanauer A. (Am. J. Hum. Genet. 1998) 3 4 23
  5. Novel mutations in Rsk-2, the gene for Coffin-Lowry syndrome (CLS). (PMID: 10094187) Abidi F. … Schwartz C.E. (Eur. J. Hum. Genet. 1999) 3 4 23

Products for RPS6KA3 Gene

Sources for RPS6KA3 Gene

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