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Aliases for RPS6KA2 Gene

Aliases for RPS6KA2 Gene

  • Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 2 2 3
  • RSK3 3 4 6
  • MAP Kinase-Activated Protein Kinase 1c 3 4
  • 90 KDa Ribosomal Protein S6 Kinase 2 3 4
  • MAPK-Activated Protein Kinase 1c 3 4
  • Ribosomal S6 Kinase 3 3 4
  • MAPKAP Kinase 1c 3 4
  • S6K-Alpha-2 3 4
  • EC 4 64
  • MAPKAPK-1c 3 4
  • P90-RSK 2 3 4
  • MAPKAPK1C 3 4
  • Pp90RSK3 3 4
  • P90RSK2 3 4
  • RSK-3 3 4
  • Ribosomal Protein S6 Kinase, 90kD, Polypeptide 2 2
  • Ribosomal Protein S6 Kinase 90kDa Polypeptide 2 3
  • Ribosomal Protein S6 Kinase Alpha 2 3
  • Ribosomal Protein S6 Kinase Alpha-2 3
  • S6K-Alpha2 3
  • S6K-Alpha 3
  • EC 2.7.11 64
  • P90-RSK3 3
  • HU-2 3
  • RSK 3

External Ids for RPS6KA2 Gene

Summaries for RPS6KA2 Gene

Entrez Gene Summary for RPS6KA2 Gene

  • This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS6KA2 Gene

RPS6KA2 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 2) is a Protein Coding gene. Diseases associated with RPS6KA2 include coffin-lowry syndrome. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include protein serine/threonine kinase activity and ribosomal protein S6 kinase activity. An important paralog of this gene is MKNK2.

UniProtKB/Swiss-Prot for RPS6KA2 Gene

  • Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.

Tocris Summary for RPS6KA2 Gene

  • p90 ribosomal S6 kinases (RSKs) are a family of protein serine/threonine kinases that regulate diverse cellular processes such as cell growth, motility, survival and proliferation. There are four isoforms of this enzyme; RSK1-4, which are directly activated by ERK1/2 in response to growth factors, many polypeptide hormones, neurotransmitters and chemokines. p90 RSKs phosphorylate numerous cytosolic and nuclear targets and act as downstream effectors of the ERK/MAPK signaling cascade. They are expressed ubiquitously in human tissues and exist in multiple subcellular compartments. Abberant activation of p90 RSKs has been linked to many human diseases, including breast and prostate cancers.

Gene Wiki entry for RPS6KA2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS6KA2 Gene

Genomics for RPS6KA2 Gene

Genomic Location for RPS6KA2 Gene

166,409,364 bp from pter
166,906,451 bp from pter
497,088 bases
Minus strand

Genomic View for RPS6KA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPS6KA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS6KA2 Gene

Regulatory Elements for RPS6KA2 Gene

Proteins for RPS6KA2 Gene

  • Protein details for RPS6KA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribosomal protein S6 kinase alpha-2
    Protein Accession:
    Secondary Accessions:
    • B3KTK9
    • Q15419
    • Q59GJ3
    • Q5TI68
    • Q96J38
    • Q9UJN5

    Protein attributes for RPS6KA2 Gene

    733 amino acids
    Molecular mass:
    83239 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells. Transiently dissociates following mitogenic stimulation (By similarity).
    • Sequence=AAC82496.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAD92353.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG53121.1; Type=Frameshift; Positions=527; Evidence={ECO:0000305};

    Alternative splice isoforms for RPS6KA2 Gene


neXtProt entry for RPS6KA2 Gene

Proteomics data for RPS6KA2 Gene at MOPED

Post-translational modifications for RPS6KA2 Gene

  • Activated by phosphorylation at Ser-218 by PDPK1. Autophosphorylated on Ser-377, as part of the activation process. May be phosphorylated at Thr-356 and Ser-360 by MAPK1/ERK2 and MAPK3/ERK1 (By similarity).
  • N-terminal myristoylation results in an activated kinase in the absence of added growth factors.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys630

Domains for RPS6KA2 Gene


  • Contains 1 AGC-kinase C-terminal domain.:
    • Q15349
  • Contains 2 protein kinase domains.:
    • Q15349
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.:
    • Q15349
genes like me logo Genes that share domains with RPS6KA2: view

Function for RPS6KA2 Gene

Molecular function for RPS6KA2 Gene

GENATLAS Biochemistry: ribosomal S6 kinase,90kDa,polypeptide 2,growth factor regulated serine/threonine kinase family,predominantly expressed in lung and skeletal muscle,not involved in vivo in the phosphorylation of RPS6,mediating protein synthesis initiation and elongation induced by hormones or growth factors,maybe playing an essentilal regulatory role in protein synthesis during cell proliferation
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Upon extracellular signal or mitogen stimulation, phosphorylated at Thr-570 in the C-terminal kinase domain (CTKD) by MAPK1/ERK2 and MAPK3/ERK1. The activated CTKD then autophosphorylates Ser-377, allowing binding of PDPK1, which in turn phosphorylates Ser-218 in the N-terminal kinase domain (NTDK) leading to the full activation of the protein and subsequent phosphorylation of the substrates by the NTKD.
UniProtKB/Swiss-Prot Function: Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.

Enzyme Numbers (IUBMB) for RPS6KA2 Gene

Gene Ontology (GO) - Molecular Function for RPS6KA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity TAS 7623830
GO:0004711 ribosomal protein S6 kinase activity IBA --
GO:0004712 protein serine/threonine/tyrosine kinase activity IDA 22797923
genes like me logo Genes that share ontologies with RPS6KA2: view

Phenotypes for RPS6KA2 Gene

genes like me logo Genes that share phenotypes with RPS6KA2: view

Animal Models for RPS6KA2 Gene

MGI Knock Outs for RPS6KA2:

miRNA for RPS6KA2 Gene

miRTarBase miRNAs that target RPS6KA2

No data available for Transcription Factor Targeting and HOMER Transcription for RPS6KA2 Gene

Localization for RPS6KA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS6KA2 Gene

Nucleus. Cytoplasm.

Subcellular locations from

Jensen Localization Image for RPS6KA2 Gene COMPARTMENTS Subcellular localization image for RPS6KA2 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 3
cytoskeleton 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for RPS6KA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 16878154
GO:0005819 spindle IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RPS6KA2: view

Pathways for RPS6KA2 Gene

genes like me logo Genes that share pathways with RPS6KA2: view

Gene Ontology (GO) - Biological Process for RPS6KA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001556 oocyte maturation IEA --
GO:0002035 brain renin-angiotensin system IEA --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with RPS6KA2: view

Compounds for RPS6KA2 Gene

(3) Tocris Compounds for RPS6KA2 Gene

Compound Action Cas Number
BRD 7389 p90 ribosomal S6 kinase inhibitor [376382-11-5]
PF 4708671 S6K1 inhibitor [1255517-76-0]
SL 0101-1 Selective p90 ribosomal S6 kinase (RSK) inhibitor [77307-50-7]

(1) HMDB Compounds for RPS6KA2 Gene

Compound Synonyms Cas Number PubMed IDs
  • Magnesium

(2) Novoseek inferred chemical compound relationships for RPS6KA2 Gene

Compound -log(P) Hits PubMed IDs
threonine 47.2 1
serine 33.9 1
genes like me logo Genes that share compounds with RPS6KA2: view

Transcripts for RPS6KA2 Gene

Unigene Clusters for RPS6KA2 Gene

Ribosomal protein S6 kinase, 90kDa, polypeptide 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPS6KA2 Gene

No ASD Table

Relevant External Links for RPS6KA2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS6KA2 Gene

mRNA expression in normal human tissues for RPS6KA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS6KA2 Gene

SOURCE GeneReport for Unigene cluster for RPS6KA2 Gene Hs.655277

mRNA Expression by UniProt/SwissProt for RPS6KA2 Gene

Tissue specificity: Widely expressed with higher expression in lung, skeletal muscle, brain, uterus, ovary, thyroid and prostate.
genes like me logo Genes that share expressions with RPS6KA2: view

Orthologs for RPS6KA2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS6KA2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPS6KA2 36
  • 95.32 (n)
  • 94.99 (a)
RPS6KA2 37
  • 99 (a)
(Bos Taurus)
Mammalia RPS6KA2 36
  • 88.86 (n)
  • 96.86 (a)
RPS6KA2 37
  • 93 (a)
(Canis familiaris)
Mammalia RPS6KA2 36
  • 89.25 (n)
  • 97 (a)
RPS6KA2 37
  • 91 (a)
(Mus musculus)
Mammalia Rps6ka2 36
  • 87.72 (n)
  • 95.63 (a)
Rps6ka2 16
Rps6ka2 37
  • 92 (a)
(Monodelphis domestica)
Mammalia RPS6KA2 37
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 87 (a)
-- 37
  • 92 (a)
(Rattus norvegicus)
Mammalia Rps6ka2 36
  • 86.99 (n)
  • 95.63 (a)
(Gallus gallus)
Aves RPS6KA2 36
  • 81.63 (n)
  • 94.13 (a)
RPS6KA2 37
  • 91 (a)
(Anolis carolinensis)
Reptilia RPS6KA2 37
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rps6ka2 36
  • 73.99 (n)
  • 87.5 (a)
(Danio rerio)
Actinopterygii rps6ka2 36
  • 75.76 (n)
  • 89.09 (a)
RPS6KA2 37
  • 86 (a)
fruit fly
(Drosophila melanogaster)
Insecta S6kII 37
  • 48 (a)
Pk17E 38
  • 41 (a)
S6kII 38
  • 58 (a)
(Caenorhabditis elegans)
Secernentea rskn-1 37
  • 53 (a)
F28C10.3 38
  • 36 (a)
T01H8.1b 38
  • 62 (a)
R04A9.5 38
  • 44 (a)
(Glycine max)
eudicotyledons Gma.186 36
(Oryza sativa)
Liliopsida Os.6126 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 68 (a)
Species with no ortholog for RPS6KA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS6KA2 Gene

Gene Tree for RPS6KA2 (if available)
Gene Tree for RPS6KA2 (if available)

Paralogs for RPS6KA2 Gene

Selected SIMAP similar genes for RPS6KA2 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with RPS6KA2: view

Variants for RPS6KA2 Gene

Sequence variations from dbSNP and Humsavar for RPS6KA2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs2984 -- 166,412,533(-) CAAGC(A/G)AAACC utr-variant-3-prime
rs12950 -- 166,410,313(-) TCTTA(C/G)AATTC utr-variant-3-prime
rs364938 -- 166,764,227(+) ATCGC(A/C)CGGCA intron-variant
rs365697 -- 166,765,302(+) GTGCG(C/T)CCAGC intron-variant
rs377794 -- 166,764,238(+) CAGTG(C/T)GGTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPS6KA2 Gene

Variant ID Type Subtype PubMed ID
esv2485852 CNV Insertion 19546169
esv1684843 CNV Insertion 17803354
nsv886937 CNV Loss 21882294
nsv823928 CNV Loss 20364138
esv2733185 CNV Deletion 23290073
dgv7035n71 CNV Loss 21882294
esv2733186 CNV Deletion 23290073
esv2733187 CNV Deletion 23290073
esv2733188 CNV Deletion 23290073
esv2733189 CNV Deletion 23290073
nsv886940 CNV Loss 21882294
dgv400n21 CNV Loss 19592680
nsv7388 OTHER Inversion 18451855
esv2678517 CNV Deletion 23128226
esv2733190 CNV Deletion 23290073
nsv886941 CNV Loss 21882294
nsv5591 CNV Insertion 18451855
nsv5592 CNV Loss 18451855
esv2733191 CNV Deletion 23290073
esv2580547 CNV Deletion 19546169
esv2182887 CNV Deletion 18987734
dgv1170e199 CNV Deletion 23128226
nsv349126 CNV Loss 16902084
esv23654 CNV Loss 19812545
esv2733192 CNV Deletion 23290073
esv2733193 CNV Deletion 23290073
esv2672309 CNV Deletion 23128226
esv2733194 CNV Deletion 23290073
esv3720 CNV Deletion 18987735
esv22598 CNV Loss 19812545
esv7295 CNV Gain 19470904
esv272233 CNV Insertion 20981092
esv267636 CNV Insertion 20981092
esv1742910 CNV Insertion 17803354
esv271508 CNV Insertion 20981092
esv25052 CNV Loss 19812545
esv29465 CNV Gain+Loss 19812545
esv2507832 CNV Deletion 19546169
esv2733196 CNV Deletion 23290073
esv2733197 CNV Deletion 23290073
esv2733198 CNV Deletion 23290073
esv2733199 CNV Deletion 23290073
esv2733200 CNV Deletion 23290073
esv2677188 CNV Deletion 23128226
esv269075 CNV Insertion 20981092
esv2733201 CNV Deletion 23290073
esv24794 CNV Gain+Loss 19812545
esv2662308 CNV Deletion 23128226
esv2666760 CNV Deletion 23128226
esv1965634 CNV Deletion 18987734
nsv518561 CNV Loss 19592680
nsv886942 CNV Loss 21882294
esv2673126 CNV Deletion 23128226
esv2733202 CNV Deletion 23290073
esv2733203 CNV Deletion 23290073
esv1002461 CNV Deletion 20482838
esv1538758 CNV Deletion 17803354
nsv348883 CNV Loss 16902084

Relevant External Links for RPS6KA2 Gene

HapMap Linkage Disequilibrium report

Disorders for RPS6KA2 Gene

(1) MalaCards Diseases for RPS6KA2 Gene

Search for RPS6KA2 Gene in MalaCards »

(1) Novoseek inferred disease relationships for RPS6KA2 Gene

Disease -log(P) Hits PubMed IDs
cancer 0 1

Relevant External Links for RPS6KA2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RPS6KA2: view

No data available for UniProtKB/Swiss-Prot for RPS6KA2 Gene

Publications for RPS6KA2 Gene

  1. Human rsk isoforms: cloning and characterization of tissue-specific expression. (PMID: 8141249) Moller D.E. … Jakubowski M. (Am. J. Physiol. 1994) 2 3 4 23
  2. RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation. (PMID: 7623830) Zhao Y. … Moller D.E. (Mol. Cell. Biol. 1995) 3 4 23
  3. 90-kDa ribosomal S6 kinase is phosphorylated and activated by 3- phosphoinositide-dependent protein kinase-1. (PMID: 10480933) Jensen C.J. … Froedin M. (J. Biol. Chem. 1999) 3 4 23
  4. RPS6KA2, a putative tumour suppressor gene at 6q27 in sporadic epithelial ovarian cancer. (PMID: 16878154) Bignone P.A. … Ganesan T.S. (Oncogene 2007) 3 4 23
  5. The RSK family of kinases: emerging roles in cellular signalling. (PMID: 18813292) Anjum R. … Blenis J. (Nat. Rev. Mol. Cell Biol. 2008) 4 23

Products for RPS6KA2 Gene

Sources for RPS6KA2 Gene

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