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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RPS6KA2 Gene

protein-coding GIFtS: 68
GCID: GC06M166822

ribosomal protein S6 kinase, 90kDa, polypeptide 2

(Previous names: ribosomal protein S6 kinase, 90kD, polypeptide 2 )

Explore 17 diseases affiliated with
RPS6KA2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 2¹ ²		MAPKAP Kinase 1c² ³
RSK3¹ ² ³ ⁵		P90-RSK 2² ³
HU-2¹ ²		P90RSK2¹
RSK¹ ²		Pp90RSK3¹
Ribosomal S6 Kinase 3² ³		EC 2.7.11.1³ ⁸
90 KDa Ribosomal Protein S6 Kinase 2² ³		Ribosomal Protein S6 Kinase, 90kD, Polypeptide 2¹
MAPKAPK-1c² ³		S6K-Alpha¹
MAPKAPK1C² ³		S6K-Alpha2¹
RSK-3² ³		P90-RSK3¹
S6K-Alpha-2¹		Ribosomal Protein S6 Kinase Alpha 2²
MAP Kinase-Activated Protein Kinase 1c² ³		Ribosomal Protein S6 Kinase Alpha-2²
MAPK-Activated Protein Kinase 1c² ³		EC 2.7.11⁸

External Ids:	HGNC: 10431¹	Entrez Gene: 6196²	Ensembl: ENSG00000071242⁷	OMIM: 601685⁵	UniProtKB: Q15349³

Export aliases for RPS6KA2 gene to outside databases

Previous GC identifers: GC06M166179 GC06M166698 GC06M166734 GC06M166733 GC06M166795 GC06M166742 GC06M164294

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RPS6KA2:

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2

non-identical kinase catalytic domains and phosphorylates various substrates, including members of the

mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling

cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been

characterized. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KS6A2_HUMAN, Q15349

Function: Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and

mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates

cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer

cells

summary for RPS6KA2:

p90 ribosomal S6 kinases (RSKs) are a family of protein serine/threonine kinases that regulate diverse

cellular processes such as cell growth, motility, survival and proliferation. There are four isoforms of

this enzyme; RSK1-4, which are directly activated by ERK1/2 in response to growth factors, many polypeptide

hormones, neurotransmitters and chemokines. p90 RSKs phosphorylate numerous cytosolic and nuclear targets

and act as downstream effectors of the ERK/MAPK signaling cascade. They are expressed ubiquitously in human

tissues and exist in multiple subcellular compartments. Abberant activation of p90 RSKs has been linked to

many human diseases, including breast and prostate cancers.

Gene Wiki entry for RPS6KA2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_025741.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RPS6KA2 gene promoter:
NF-YB CBF-B CBF-A NF-YA CP1C CP1A AP-4 NF-Y CBF-C CBF(2)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RPS6KA2 promoter sequence

Search SABiosciences Chromatin IP Primers for RPS6KA2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS6KA2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q27 Ensembl cytogenetic band: 6q27 HGNC cytogenetic band: 6q27

RPS6KA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS6KA2 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M166822: view genomic region (about GC identifiers)

Start:	166,822,852 bp from pter	End:	167,319,939 bp from pter
Size:	497,088 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KS6A2_HUMAN, Q15349 (See protein sequence)

Recommended Name: Ribosomal protein S6 kinase alpha-2

Size: 733 amino acids; 83239 Da

Cofactor: Magnesium

Subunit: Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells. Transiently dissociates following

mitogenic stimulation (By similarity)

Subcellular location: Nucleus. Cytoplasm

Sequence caution: Sequence=AAC82496.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Sequence=BAD92353.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAG53121.1;

Type=Frameshift; Positions=527;

Secondary accessions: B3KTK9 Q15419 Q59GJ3 Q5TI68 Q96J38 Q9UJN5

Alternative splicing: 3 isoforms: Q15349-1 Q15349-2 Q15349-3 (Ref.3 (BAG53121) sequence is in conflict in positions: 32:E->G, 34:T->A)

Explore the universe of human proteins at neXtProt for RPS6KA2: NX_Q15349

Post-translational modifications:

Activated by phosphorylation at Ser-218 by PDPK1. Autophosphorylated on Ser-377, as part of the activation process. May

be phosphorylated at Thr-356 and Ser-360 by MAPK1/ERK2 and MAPK3/ERK1 (By similarity)¹

N-terminal myristoylation results in an activated kinase in the absence of added growth factors (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q15349

4/34 DME Specific Peptides for RPS6KA2 (Q15349) (see all 34)

VVHRDLK

CDIWSLG

IKITDFG

LYAMKVL

RPS6KA2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001006933.1 NP_066958.2

ENSEMBL proteins:

ENSP00000265678 ENSP00000422435 ENSP00000427015 ENSP00000422484 ENSP00000386050

ENSP00000422197 ENSP00000427605 ENSP00000423114 ENSP00000425148 ENSP00000425458

ENSP00000355828

Reactome Protein details: Q15349
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant RPS6KA2 Protein
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: RPS6KA2 OriGene Protein Over-expression Lysate: RPS6KA2 OriGene Custom Protein Services for RPS6KA2
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	Novus Biologicals RPS6KA2 Proteins Novus Biologicals RPS6KA2 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	16878154
GO:0005654	nucleoplasm	TAS	--
GO:0005737	cytoplasm	IDA	16878154
GO:0005819	spindle	IEA	--
GO:0005829	cytosol	TAS	--

RPS6KA2 for ontologies About GeneDecksing

RPS6KA2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of RPS6KA2
	R&D Systems Antibodies for RPS6KA2 (RSK3)
	Cell Signaling Technology (CST) Antibodies for RPS6KA2 (RSK3)
	OriGene Antibodies: RPS6KA2 OriGene Custom Antibody Services for RPS6KA2
	GenScript Custom Superior Antibodies Services for RPS6KA2
	Novus Biologicals RPS6KA2 Antibodies
	Abcam antibodies for RPS6KA2
	Browse Antibodies at Uscn
	ThermoFisher Antibodies for RPS6KA2

Assay Products for RPS6KA2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for RPS6KA2 (RSK3)
	GenScript Custom Assay Services for RPS6KA2
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RPS6KA2 for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR017441 Protein_kinase_ATP_BS

IPR002290 Ser/Thr_dual-sp_kinase_dom

IPR000961 AGC-kinase_C

IPR011009 Kinase-like_dom

IPR017892 Pkinase_C

Graphical View of Domain Structure for InterPro Entry Q15349

ProtoNet protein and cluster: Q15349

1 Blocks protein family: IPB000961 Protein kinase C-terminal domain

UniProtKB/Swiss-Prot: KS6A2_HUMAN, Q15349

Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily

Similarity: Contains 1 AGC-kinase C-terminal domain

Similarity: Contains 2 protein kinase domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: KS6A2_HUMAN, Q15349

Function: Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and

mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates

cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer

cells

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme regulation: Upon extracellular signal or mitogen stimulation, phosphorylated at Thr-570 in the C-terminal kinase

domain (CTKD) by MAPK1/ERK2 and MAPK3/ERK1. The activated CTKD then autophosphorylates Ser-377, allowing binding of

PDPK1, which in turn phosphorylates Ser-218 in the N-terminal kinase domain (NTDK) leading to the full activation of

the protein and subsequent phosphorylation of the substrates by the NTKD

Genatlas biochemistry entry for RPS6KA2:

ribosomal S6 kinase,90kDa,polypeptide 2,growth factor regulated serine/threonine kinase family,predominantly expressed

in lung and skeletal muscle,not involved in vivo in the phosphorylation of RPS6,mediating protein synthesis initiation

and elongation induced by hormones or growth factors,maybe playing an essentilal regulatory role in protein synthesis

during cell proliferation

Enzyme Numbers (IUBMB): EC 2.7.11.1¹ ² EC 2.7.11²

miRNA Products:		OriGene 3'-UTR Clone (see all 2): RPS6KA2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPS6KA2
		8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate RPS6KA2 (see all 62):
		hsa-miR-21* hsa-miR-26a-2* hsa-miR-302d hsa-miR-520e hsa-miR-429 hsa-miR-4272 hsa-miR-106a hsa-miR-605

		SwitchGear 3'UTR luciferase reporter plasmid: RPS6KA2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPS6KA2 (see all 3) Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS6KA2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for RPS6KA2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPS6KA2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPS6KA2 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): RPS6KA2 (NM_021135)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS6KA2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RPS6KA2
		Search LifeMap BioReagents cell lines for RPS6KA2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS6KA2

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000287	magnesium ion binding	IEA	--
GO:0004672	protein kinase activity	--	--
GO:0004674	protein serine/threonine kinase activity	TAS	7623830
GO:0004711	ribosomal protein S6 kinase activity	IEA	--
GO:0005515	protein binding	--	--

RPS6KA2 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for RPS6KA2:

Decreased substrate adherent c

Increased number of small and

Animal Models:
1 MGI phenotypic allele

for Rps6ka2 (no phenotypes)

RPS6KA2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/40 super-pathways (see all 40) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

TRAF6 Mediated Induction of proinflammatory cytokines

8/19 pathways (see all 19)
TRAF6 Mediated Induction of proinflammatory cytokines	1.00	Toll Like Receptor TLR1:TLR2 Cascade	0.78
MAP kinase activation in TLR cascade	0.88	Toll Like Receptor 2 (TLR2) Cascade	0.78
Toll Like Receptor 5 (TLR5) Cascade	0.86	MyD88:Mal cascade initiated on plasma membrane	0.78
Toll Like Receptor 10 (TLR10) Cascade	0.86	TRIF-mediated TLR3/TLR4 signaling	0.73

Axon guidance

Axon guidance	1.00	Recycling pathway of L1	0.15
Developmental Biology	0.69	Signal transduction by L1	0.12
L1CAM interactions	0.39

Development EGFR signaling pathway

	Development_GDNF family signaling	0.45			GDNF-Family Ligands and Receptor Interactions	0.21
	Development GDNF family signaling	0.45			BDNF Pathway	0.14

Post NMDA receptor activation events

	Post NMDA receptor activation events	1.00			CREB phosphorylation through the activation of Ras	0.82
	Activation of NMDA receptor upon glutamate binding and postsynaptic events	0.89

Transmission across Chemical Synapses

	Transmission across Chemical Synapses	1.00			Neuronal System	0.67
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	0.72

Pathway sources
See GeneCards unified pathways
Show all pathways

5/7 EMD Millipore Pathways for RPS6KA2 (see all 7)

	Development EDNRB signaling
	Development A2A receptor signaling
	Development GDNF family signaling
	Transcription CREB pathway
	Development Flt3 signaling

5/16 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RPS6KA2 (see all 16)

	FLT3 Signaling
	MAPK Signaling
	Mitochondrial Apoptosis
	CNTF Signaling
	GDNF-Family Ligands and Receptor Interactions

1 Cell Signaling Technology (CST) Pathway for RPS6KA2

MAP Kinase Signaling

5 Tocris Bioscience Pathways for RPS6KA2

	Insulin Pathway
	Apoptosis Pathway
	NF-kappaB Pathway
	MAPK Pathway
	mTOR Pathway

5/7 GeneGo (Thomson Reuters) Pathways for RPS6KA2 (see all 7)

	Development A2A receptor signaling
	Development GDNF family signaling
	Apoptosis and survival BAD phosphorylation
	Development EDNRB signaling
	Transcription CREB pathway

5 BioSystems Pathways for RPS6KA2

	EGFR1 Signaling Pathway
	Prolactin Signaling Pathway
	IL-6 Signaling Pathway
	Insulin Signaling
	Cytoplasmic Ribosomal Proteins

5/42 Reactome Pathways for RPS6KA2 (see all 42)

	CREB phosphorylation
	L1CAM interactions
	Toll Like Receptor 2 (TLR2) Cascade
	Toll Like Receptor TLR6:TLR2 Cascade
	Post NMDA receptor activation events

5/6 Kegg Pathways (Kegg details for RPS6KA2) (see all 6):

	MAPK signaling pathway
	Oocyte meiosis
	mTOR signaling pathway
	Long-term potentiation
	Neurotrophin signaling pathway

RPS6KA2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RPS6KA2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/43 Interacting proteins for RPS6KA2 (Q15349^{2, 3} ENSP00000386050⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 43)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BRAF	P15056²^,³, ENSP00000288602⁴	MINT-2833347 MINT-2833314 I2D: score=1 STRING: ENSP00000288602
PRKCE	Q02156²^,³, ENSP00000306124⁴	MINT-2833542 MINT-2833498 I2D: score=1 STRING: ENSP00000306124
RPS6	P62753²^,³, ENSP00000369757⁴	MINT-2833465 I2D: score=1 STRING: ENSP00000369757
PRKCA	P17252²^,³, ENSP00000284384⁴	MINT-2833291 I2D: score=1 STRING: ENSP00000284384
MAPK1	P28482³, ENSP00000215832⁴	I2D: score=4 STRING: ENSP00000215832

About this table

Gene Ontology (GO): 5/31 biological process terms (GO ID links to tree view) (see all 31): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000089	mitotic metaphase	IEA	--
GO:0001556	oocyte maturation	IEA	--
GO:0002035	brain renin-angiotensin system	IEA	--
GO:0002224	toll-like receptor signaling pathway	TAS	--
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	TAS	--

RPS6KA2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RPS6KA2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for RPS6KA2 available from Tocris Bioscience About this table

Compound	Action	CAS #
SL 0101-1	Selective p90 ribosomal S6 kinase (RSK) inhibitor	[77307-50-7]

1 HMDB Compound for RPS6KA2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Magnesium	Magnesium (see all 2)	7439-95-4	--

2 Novoseek chemical compound relationships for RPS6KA2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
threonine	47.2	1	8622665 (1)
serine	33.9	1	8622665 (1)

Search CenterWatch for drugs/clinical trials and news about RPS6KA2 / KS6A2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RPS6KA2 gene (2 alternative transcripts):

NM_001006932.1 NM_021135.4

Unigene Cluster for RPS6KA2:

Ribosomal protein S6 kinase, 90kDa, polypeptide 2

Hs.655277 [show with all ESTs]

Unigene Representative Sequence: NM_021135

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000265678(uc010kkk.1 uc011ego.1 uc010kkl.1 uc003qvb.1)

ENST00000510118(uc003qvc.1 uc003qvd.1) ENST00000503859 ENST00000509742

ENST00000481261 ENST00000405189 ENST00000491836 ENST00000366865 ENST00000507350

ENST00000512860 ENST00000507371 ENST00000506565 ENST00000511034 ENST00000366863

miRNA Products:		OriGene 3'-UTR Clone (see all 2): RPS6KA2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPS6KA2
		8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate RPS6KA2 (see all 62):
		hsa-miR-21* hsa-miR-26a-2* hsa-miR-302d hsa-miR-520e hsa-miR-429 hsa-miR-4272 hsa-miR-106a hsa-miR-605

		SwitchGear 3'UTR luciferase reporter plasmid: RPS6KA2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPS6KA2 (see all 3) Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS6KA2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPS6KA2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPS6KA2 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): RPS6KA2 (NM_021135)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPS6KA2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS6KA2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPS6KA2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RPS6KA2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS6KA2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS6KA2

Additional cDNA sequence:

AB073884.1 AB209116.1 AF140710.1 AK027727.1 AK095751.1 AK295674.1 AK307470.1 AK310428.1

BC002363.2 BC011189.1 L07598.1 X85106.1

12 DOTS entries:

DT.116843 DT.97823234 DT.97843511 DT.99967882 DT.100037271 DT.100704907 DT.100782542 DT.100728537

DT.121395849 DT.95163416 DT.99934386 DT.91977232

24/534 AceView cDNA sequences (see all 534):

CA413076 CD674176 AW970144 BG054725 BC001819 CR593397 BC041056 CB243278

AA338744 AW474688 AW009717 BU682292 AI903930 CA418728 BQ712327 AI217287

AL041466 BQ231009 BE859050 AI434681 AA962266 CR623299 AI264158 AW966270

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RPS6KA2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTTTATGAA

About this image

RPS6KA2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Endocardium

Cushion Mesenchymal Cells

Endocardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

See RPS6KA2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RPS6KA2

SOURCE GeneReport for Unigene cluster: Hs.655277

UniProtKB/Swiss-Prot: KS6A2_HUMAN, Q15349

Tissue specificity: Widely expressed with higher expression in lung, skeletal muscle, brain, uterus, ovary, thyroid and

prostate

SABiosciences Expression via Pathway-Focused PCR Array including RPS6KA2:

mTOR Signaling in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS6KA2 gene from 7/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RPS6KA2¹	ribosomal protein S6 kinase, 90kDa, polypeptide 2	81.69(n) 94.58(a)		421570 XM_419611.2 XP_419611.2
lizard (Anolis carolinensis)	Reptilia	RPS6KA2⁶	--	91(a)	1 ↔ 1	1(225789077-225890028)
zebrafish (Danio rerio)	Actinopterygii	rps6ka2¹	ribosomal protein S6 kinase, 90kDa, polypeptide 2	76.13(n) 89.59(a)		571285 XM_694860.3 XP_699952.2
fruit fly (Drosophila melanogaster)	Insecta	S6kII³	protein amino acid phosphorylation protein serine/threonine more	58(a) (best of 2)		20B1 --
worm (Caenorhabditis elegans)	Secernentea	T01H8.1b³	Protein kinase C terminal domain	62(a) (best of 3)		I(8582453-8585937) --
thale cress (Arabidopsis thaliana)	eudicotyledons	S6K2⁶ ATPK1⁶	serine/threonine-protein kinase AtPK1/AtPK6	33(a) 32(a)	many ↔ many many ↔ many	3(2648509-2651160) 3(2651447-2654212)
rice (Oryza sativa)	Liliopsida	Os.6126²	Oryza sativa (japonica cultivar-group) cDNA cloneJ more	72.94(n)		AK067266.1

ENSEMBL Gene Tree for RPS6KA2 (if available)
TreeFam Gene Tree for RPS6KA2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RPS6KA2 gene

AKT1² RPS6KA6² RPS6KB1² SGK3² SGK2² RPS6KA1² AKT3² RPS6KA5²

RPS6KA4² SGK1² RPS6KB2² AKT2² RPS6KA3²

18/229 SIMAP similar genes for RPS6KA2 using alignment to 9 protein entries: KS6A2_HUMAN (see all proteins) (see all similar genes):

RPS6KA3 RPS6KA1 RPS6KA6 KIN27 SGK494 CIT

PRKACA PRKACB PKN2 PRKCE RPS6KB1 RPS6KB2

RPS6KA5 PRKCA SGK2 DKFZp564L2416 PRKACG PRKG2

RPS6KA2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3837032^1,2	C,	--	164425614(-)	`AAAAA-/ACCACT`	1	--	int¹		2		NA	4
rs112958874^1,2	C,	--	166822387(+)	`TGCACAT/-GTTTA`	2	--	ds500¹		1		CSA	2
rs116776850^1,2	F,	--	166822449(+)	`ACACAC/TGTACA`	2	--	ds500¹		1		WA	118
rs6923731^1,2	C,F,	--	166822450(+)	`cacacG/Atacac`	2	--	ds500¹		1		WA	118
rs115520749^1,2	F,	--	166822469(+)	`ATGCAT/CGAACT`	2	--	ds500¹		1		WA	118
rs199519764^1,2		--	166822519(+)	`TGTGT-/ACACACA`	2	--	ds500¹		0	--	--	--	--
rs147662382^1,2		--	166822540(+)	`CACCCA/GCCTAC`	2	--	ds500¹		0	--	--	--	--
rs72463963^1,2	C,	--	166822560(+)	`CATGT-/GCAC ACACAAGCACA`	2	--	ds500¹		0	--	--	--	--
rs66737647^1,2	C,	--	166822614(+)	`CACTT-/ACAC ACGCA`	2	--	ds500¹		0	--	--	--	--
rs59379033^1,2	C	--	166822616(+)	`CTTAC-/ACAC GCACA`	2	--	ds500¹		1		NA	2

HapMap Linkage Disequilibrium report for RPS6KA2 (166822852 - 167072852 bp, first 250kb of RPS6KA2)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 15 variations for RPS6KA2
     7 CNVs: 99798 44238 69657 99797 69656 64713 6525
     7 Indels: 47047 69659 60642 41544 99796 69655 69658
     1 Inversion: 37269

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RPS6KA2 for disorders           About GeneDecksing

OMIM gene information: 601685    OMIM disorders: --

17 diseases for RPS6KA2:    About MalaCards

coffin-lowry syndrome prostate cancer subacute sclerosing panencephalitis prostatitis

myiasis epithelial ovarian cancer ovarian cancer endocarditis

myeloid leukemia gout measles breast cancer

leukemia thyroiditis hepatitis neuronitis

alcoholism

1 Novoseek disease relationship for RPS6KA2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	0	1	16878154 (1)

Human Genome Epidemiology (HuGE) Navigator: RPS6KA2 (3 documents)

Export disorders for RPS6KA2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RPS6KA2 gene, integrated from 9 sources (see all 67):
(articles sorted by number of sources associating them with RPS6KA2)

Utopia: connect your pdf to the dynamic
world of online information

Human rsk isoforms: cloning and characterization of tissue-specific expression. (PubMed id 8141249)^{1, 2, 3, 9} Moller D.E.... Jakubowski M. (1994)
RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation. (PubMed id 7623830)^{1, 2, 9} Zhao Y.... Moller D.E. (1995)
RPS6KA2, a putative tumour suppressor gene at 6q27 in sporadic epithelial ovarian cancer. (PubMed id 16878154)^{1, 2, 9} Bignone P.A....Ganesan T.S. (2007)
90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1. (PubMed id 10480933)^{1, 2, 9} Jensen C.J....Frodin M. (1999)
Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)^{1, 2} Denis N.J.... Figeys D. (2007)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases. (PubMed id 8939914)^{1, 9} Zhao Y....Moller D.E. (1996)
The RSK family of kinases: emerging roles in cellular signalling. (PubMed id 18813292)^{2, 9} Anjum R. and Blenis J. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6196	HGNC: 10431	AceView: RNASET2andRPS6KA2	Ensembl:ENSG00000071242	euGenes: HUgn6196
ECgene: RPS6KA2	Kegg: 6196	H-InvDB: RPS6KA2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RPS6KA2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RPS6KA2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for RPS6KA2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for RPS6KA2 gene:
Search GeneIP for patents involving RPS6KA2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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RPS6KA2 Gene

ribosomal protein S6 kinase, 90kDa, polypeptide 2

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RPS6KA2 (Gene Symbol)
Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 2
RSK3
HU-2
RSK
Ribosomal S6 Kinase 3
90 KDa Ribosomal Protein S6 Kinase 2
MAPKAPK-1c
MAPKAPK1C
RSK-3
S6K-Alpha-2
MAP Kinase-Activated Protein Kinase 1c
MAPK-Activated Protein Kinase 1c
MAPKAP Kinase 1c
P90-RSK 2
P90RSK2
Pp90RSK3
EC 2.7.11.1
Ribosomal Protein S6 Kinase, 90kD, Polypeptide 2
S6K-Alpha
S6K-Alpha2
P90-RSK3
Ribosomal Protein S6 Kinase Alpha 2
Ribosomal Protein S6 Kinase Alpha-2
EC 2.7.11

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RPS6KA2 Gene

ribosomal protein S6 kinase, 90kDa, polypeptide 2

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