Aliases for RPS6KA2 Gene
- Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 2 2 3
- MAP Kinase-Activated Protein Kinase 1c 3 4
- 90 KDa Ribosomal Protein S6 Kinase 2 3 4
- MAPK-Activated Protein Kinase 1c 3 4
- Ribosomal S6 Kinase 3 3 4
- MAPKAP Kinase 1c 3 4
- S6K-Alpha-2 3 4
- EC 188.8.131.52 4 63
- MAPKAPK-1c 3 4
- P90-RSK 2 3 4
- MAPKAPK1C 3 4
- Pp90RSK3 3 4
- P90RSK2 3 4
External Ids for RPS6KA2 Gene
Previous GeneCards Identifiers for RPS6KA2 Gene
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for RPS6KA2 Gene
RPS6KA2 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 2) is a Protein Coding gene. Diseases associated with RPS6KA2 include dental caries. Among its related pathways are MAPK signaling pathway and Immune System. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MKNK2.
UniProtKB/Swiss-Prot for RPS6KA2 Gene
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.
Ribosomal S6 protein kinases (RSKs) are a family of protein serine/threonine kinases that regulate diverse cellular processes such as cellular growth, motility, survival and proliferation. The RSK family can be divided into two subfamilies, namely p90 RSK and p70 S6K.