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RPS6KA2 Gene

protein-coding   GIFtS: 71
GCID: GC06M166822

Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 2

(Previous names: ribosomal protein S6 kinase, 90kD, polypeptide 2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 21 2     p90RSK22 3
RSK32 3 5     pp90RSK32 3
Ribosomal S6 Kinase 32 3     EC 2.7.11.13 8
90 KDa Ribosomal Protein S6 Kinase 22 3     Ribosomal Protein S6 Kinase, 90kD, Polypeptide 21
MAPKAPK-1c2 3     HU-22
MAPKAPK1C2 3     RSK2
RSK-32 3     S6K-alpha2
S6K-alpha-22 3     S6K-alpha22
MAP Kinase-Activated Protein Kinase 1c2 3     p90-RSK32
MAPK-Activated Protein Kinase 1c2 3     Ribosomal Protein S6 Kinase Alpha 22
MAPKAP Kinase 1c2 3     Ribosomal Protein S6 Kinase Alpha-22
P90-RSK 22 3     EC 2.7.118

External Ids:    HGNC: 104311   Entrez Gene: 61962   Ensembl: ENSG000000712427   OMIM: 6016855   UniProtKB: Q153493   

Export aliases for RPS6KA2 gene to outside databases

Previous GC identifers: GC06M166179 GC06M166698 GC06M166734 GC06M166733 GC06M166795 GC06M166742 GC06M164294


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RPS6KA2 Gene:
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase
contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the
mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in
controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different
isoforms, have been characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for RPS6KA2 Gene:
RPS6KA2 (ribosomal protein S6 kinase, 90kDa, polypeptide 2) is a protein-coding gene. Diseases associated with RPS6KA2 include myiasis, and coffin-lowry syndrome. GO annotations related to this gene include ribosomal protein S6 kinase activity and protein serine/threonine kinase activity. An important paralog of this gene is RPS6KA6.

UniProtKB/Swiss-Prot: KS6A2_HUMAN, Q15349
Function: Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and
mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates
cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian
cancer cells

summary for RPS6KA2 Gene:
p90 ribosomal S6 kinases (RSKs) are a family of protein serine/threonine kinases that regulate diverse
cellular processes such as cell growth, motility, survival and proliferation. There are four isoforms of
this enzyme; RSK1-4, which are directly activated by ERK1/2 in response to growth factors, many polypeptide
hormones, neurotransmitters and chemokines. p90 RSKs phosphorylate numerous cytosolic and nuclear targets
and act as downstream effectors of the ERK/MAPK signaling cascade. They are expressed ubiquitously in human
tissues and exist in multiple subcellular compartments. Abberant activation of p90 RSKs has been linked to
many human diseases, including breast and prostate cancers.

Gene Wiki entry for RPS6KA2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPS6KA2 gene promoter:
         NF-YB   CBF-B   CBF-A   NF-YA   CP1C   CP1A   AP-4   NF-Y   CBF-C   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RPS6KA2 promoter sequence
   Search Chromatin IP Primers for RPS6KA2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPS6KA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q27   Ensembl cytogenetic band:  6q27   HGNC cytogenetic band: 6q27

RPS6KA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS6KA2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M166822:  view genomic region     (about GC identifiers)

Start:
166,822,852 bp from pter      End:
167,319,939 bp from pter
Size:
497,088 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KS6A2_HUMAN, Q15349 (See protein sequence)
Recommended Name: Ribosomal protein S6 kinase alpha-2  
Size: 733 amino acids; 83239 Da
Cofactor: Magnesium
Subunit: Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells. Transiently dissociates
following mitogenic stimulation (By similarity)
Sequence caution: Sequence=AAC82496.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAD92353.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAG53121.1;
Type=Frameshift; Positions=527;
Secondary accessions: B3KTK9 Q15419 Q59GJ3 Q5TI68 Q96J38 Q9UJN5
Alternative splicing: 3 isoforms:  Q15349-1   Q15349-2   Q15349-3   (Ref.3 (BAG53121) sequence is in conflict in positions: 32:E->G, 34:T->A)

Explore the universe of human proteins at neXtProt for RPS6KA2: NX_Q15349

Explore proteomics data for RPS6KA2 at MOPED

Post-translational modifications: 

  • Activated by phosphorylation at Ser-218 by PDPK1. Autophosphorylated on Ser-377, as part of the activation
    process. May be phosphorylated at Thr-356 and Ser-360 by MAPK1/ERK2 and MAPK3/ERK1 (By similarity)1
  • N-terminal myristoylation results in an activated kinase in the absence of added growth factors (By similarity)1
  • Ubiquitination2 at Lys630
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for RPS6KA2 (Q15349) (see all 34)
     VVHRDLK  CDIWSLG  IKITDFG  LYAMKVL 


    See RPS6KA2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001006933.1  NP_066958.2  

    ENSEMBL proteins: 
     ENSP00000265678   ENSP00000422435   ENSP00000427015   ENSP00000422484   ENSP00000386050  
     ENSP00000422197   ENSP00000427605   ENSP00000423114   ENSP00000425148   ENSP00000425458  
     ENSP00000355828  
    Reactome Protein details: Q15349

    RPS6KA2 Human Recombinant Protein Products:

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    Novus Biologicals RPS6KA2 Proteins
    Novus Biologicals RPS6KA2 Lysate
    Sino Biological Recombinant Protein for RPS6KA2
    Sino Biological Cell Lysate for RPS6KA2
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    RPS6KA2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of RPS6KA2
    R&D Systems Antibodies for RPS6KA2 (RSK3)
    Cell Signaling Technology (CST) Antibodies for RPS6KA2  (RSK3)
    OriGene Antibodies for RPS6KA2
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    Novus Biologicals RPS6KA2 Antibodies
    Abcam antibodies for RPS6KA2
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    ThermoFisher Antibodies for RPS6KA2
    LSBio Antibodies in human, mouse, rat for RPS6KA2

    RPS6KA2 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of RPS6KA2
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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: ribosomal protein S6 kinase, 90kDa, polypeptide 2
    RSK subfamily
    Other AGC kinases

    Selected InterPro protein domains (see all 8):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR000961 AGC-kinase_C
     IPR011009 Kinase-like_dom
     IPR017892 Pkinase_C

    Graphical View of Domain Structure for InterPro Entry Q15349

    ProtoNet protein and cluster: Q15349

    1 Blocks protein domain: IPB000961 Protein kinase C-terminal domain

    UniProtKB/Swiss-Prot: KS6A2_HUMAN, Q15349
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 2 protein kinase domains


    RPS6KA2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KS6A2_HUMAN, Q15349
    Function: Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and
    mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates
    cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian
    cancer cells
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Upon extracellular signal or mitogen stimulation, phosphorylated at Thr-570 in the C-terminal
    kinase domain (CTKD) by MAPK1/ERK2 and MAPK3/ERK1. The activated CTKD then autophosphorylates Ser-377, allowing
    binding of PDPK1, which in turn phosphorylates Ser-218 in the N-terminal kinase domain (NTDK) leading to the full
    activation of the protein and subsequent phosphorylation of the substrates by the NTKD

         Genatlas biochemistry entry for RPS6KA2:
    ribosomal S6 kinase,90kDa,polypeptide 2,growth factor regulated serine/threonine kinase family,predominantly
    expressed in lung and skeletal muscle,not involved in vivo in the phosphorylation of RPS6,mediating protein
    synthesis initiation and elongation induced by hormones or growth factors,maybe playing an essentilal regulatory
    role in protein synthesis during cell proliferation

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity TAS7623830
    GO:0004711ribosomal protein S6 kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
         
    RPS6KA2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RPS6KA2:
     Decreased substrate adherent c  Increased number of small and  

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rps6ka2):
     cardiovascular system  homeostasis/metabolism  muscle 

    RPS6KA2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rps6ka2tm1.1Mskf for RPS6KA2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RPS6KA2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RPS6KA2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RPS6KA2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RPS6KA2

    miRNA
    Products:
        
    miRTarBase miRNAs that target RPS6KA2:
    hsa-mir-335-5p (MIRT018582)

    Block miRNA regulation of human, mouse, rat RPS6KA2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RPS6KA2 (see all 62):
    hsa-miR-21* hsa-miR-26a-2* hsa-miR-302d hsa-miR-520e hsa-miR-429 hsa-miR-4272 hsa-miR-106a hsa-miR-605
    SwitchGear 3'UTR luciferase reporter plasmidRPS6KA2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RPS6KA2
    Predesigned siRNA for gene silencing in human, mouse, rat RPS6KA2

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for RPS6KA2 (see all 13)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RPS6KA2 (NM_021135)
    Sino Biological Human cDNA Clone for RPS6KA2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPS6KA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS6KA2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for RPS6KA2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS6KA2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KS6A2_HUMAN, Q15349: Nucleus. Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    plasma membrane3
    cytoskeleton2
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA16878154
    GO:0005819spindle IEA--

    RPS6KA2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RPS6KA2 About   (see all 38)  
    See pathways by source

    SuperPathContained pathways About
    1MAPK targets/ Nuclear events mediated by MAP kinases
    ERK/MAPK targets0.88
    MAP kinase activation in TLR cascade0.61
    Nuclear Events (kinase and transcription factor activation)0.88
    MAP Kinase Signaling0.31
    MAPK targets/ Nuclear events mediated by MAP kinases0.80
    CREB phosphorylation0.00
    2Post NMDA receptor activation events
    Post NMDA receptor activation events0.90
    Long-term potentiation0.35
    Activation of NMDA receptor upon glutamate binding and postsynaptic events0.90
    RSK activation0.00
    CREB phosphorylation through the activation of Ras0.78
    3Development EGFR signaling pathway
    Development GDNF family signaling0.45
    BDNF Pathway0.39
    GDNF-Family Ligands and Receptor Interactions0.41
    4Development IGF 1 receptor signaling
    Development IGF RI signaling0.49
    Development IGF 1 receptor signaling0.48
    5Development Dopamine D2 receptor transactivation of EGFR
    Apoptosis and survival BAD phosphorylation0.41
    BAD Phosphorylation0.41

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RPS6KA2 (see all 16)
        FLT3 Signaling
    MAPK Signaling
    Mitochondrial Apoptosis
    CNTF Signaling
    GDNF-Family Ligands and Receptor Interactions

    1 Cell Signaling Technology (CST) Pathway for RPS6KA2
        MAP Kinase Signaling

    5 Tocris Bioscience Pathways for RPS6KA2
        Insulin Pathway
    Apoptosis Pathway
    NF-kappaB Pathway
    MAPK Pathway
    mTOR Pathway

    Selected GeneGo (Thomson Reuters) Pathways for RPS6KA2 (see all 7)
        Development A2A receptor signaling
    Development GDNF family signaling
    Apoptosis and survival BAD phosphorylation
    Development EDNRB signaling
    Transcription CREB pathway

    5 BioSystems Pathways for RPS6KA2
        EGFR1 Signaling Pathway
    Insulin Signaling
    IL-6 Signaling Pathway
    Cytoplasmic Ribosomal Proteins
    Prolactin Signaling Pathway


    Selected Reactome Pathways for RPS6KA2 (see all 7)
        CREB phosphorylation
    Recycling pathway of L1
    Senescence-Associated Secretory Phenotype (SASP)
    RSK activation
    Gastrin-CREB signalling pathway via PKC and MAPK


    Selected Kegg Pathways  (Kegg details for RPS6KA2) (see all 6):
        MAPK signaling pathway
    Oocyte meiosis
    mTOR signaling pathway
    Long-term potentiation
    Neurotrophin signaling pathway


    RPS6KA2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including RPS6KA2: 
              mTOR Signaling in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RPS6KA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPS6KA2 (Q153491, 2, 3 ENSP000003860504) via UniProtKB, MINT, STRING, and/or I2D (see all 64)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BRAFP150561, 2, 3, ENSP000002886024EBI-1384149,EBI-365980 MINT-2833347 MINT-2833314 I2D: score=1 STRING: ENSP00000288602
    PRKCEQ021561, 2, 3, ENSP000003061244EBI-1384149,EBI-706254 MINT-2833542 MINT-2833498 I2D: score=1 STRING: ENSP00000306124
    PRKCAP172522, 3, ENSP000002843844MINT-2833291 I2D: score=1 STRING: ENSP00000284384
    RPS6P627532, 3, ENSP000003697574MINT-2833465 I2D: score=1 STRING: ENSP00000369757
    MAPK1P284823, ENSP000002158324I2D: score=4 STRING: ENSP00000215832
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 34):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001556oocyte maturation IEA--
    GO:0002035brain renin-angiotensin system IEA--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--

    RPS6KA2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for RPS6KA2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BRD 7389p90 ribosomal S6 kinase inhibitor[376382-11-5]
    PF 4708671S6K1 inhibitor[1255517-76-0]
    SL 0101-1Selective p90 ribosomal S6 kinase (RSK) inhibitor[77307-50-7]

    1 HMDB Compound for RPS6KA2    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--

    2 Novoseek inferred chemical compound relationships for RPS6KA2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 47.2 1 8622665 (1)
    serine 33.9 1 8622665 (1)



    RPS6KA2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RPS6KA2 gene (2 alternative transcripts): 
    NM_001006932.1  NM_021135.4  

    Unigene Cluster for RPS6KA2:

    Ribosomal protein S6 kinase, 90kDa, polypeptide 2
    Hs.655277  [show with all ESTs]
    Unigene Representative Sequence: NM_021135
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265678(uc010kkk.1 uc011ego.1 uc010kkl.1 uc003qvb.1)
    ENST00000510118(uc003qvc.1 uc003qvd.1) ENST00000503859 ENST00000509742
    ENST00000481261 ENST00000405189 ENST00000491836 ENST00000366865 ENST00000507350
    ENST00000512860 ENST00000507371 ENST00000506565 ENST00000511034 ENST00000366863

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RPS6KA2 (see all 62):
    hsa-miR-21* hsa-miR-26a-2* hsa-miR-302d hsa-miR-520e hsa-miR-429 hsa-miR-4272 hsa-miR-106a hsa-miR-605
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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): RPS6KA2 (NM_021135)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS6KA2
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      QuantiTect SYBR Green Assays in human, mouse, rat RPS6KA2
      QuantiFast Probe-based Assays in human, mouse, rat RPS6KA2

    Additional mRNA sequence: 

    AB073884.1 AB209116.1 AF140710.1 AK027727.1 AK095751.1 AK295674.1 AK307470.1 AK310428.1 
    BC002363.2 BC011189.1 L07598.1 X85106.1 

    12 DOTS entries:

    DT.116843  DT.97823234  DT.97843511  DT.99967882  DT.100037271  DT.100704907  DT.100782542  DT.100728537 
    DT.121395849  DT.95163416  DT.99934386  DT.91977232 

    Selected AceView cDNA sequences (see all 534):

    AA515670 CA309109 BU617697 AA223163 AA884722 AA514262 AI288444 BC019871 
    CN478672 AI016296 NM_003730 BU542931 BM708904 AW582519 AI817789 AI992251 
    BF432000 AI361416 AA281822 AA903740 BC036282 AA447507 BF446274 AA947951 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RPS6KA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTTATGAA
    RPS6KA2 Expression
    About this image


    RPS6KA2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Heart (Cardiovascular System)
             Cushion Mesenchymal Cells Endocardium
     
     Kidney (Urinary System)
             Metanephros
    RPS6KA2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPS6KA2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655277

    UniProtKB/Swiss-Prot: KS6A2_HUMAN, Q15349
    Tissue specificity: Widely expressed with higher expression in lung, skeletal muscle, brain, uterus, ovary,
    thyroid and prostate

        Pathway & Disease-focused RT2 Profiler PCR Array including RPS6KA2: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPS6KA2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rps6ka21 , 5 ribosomal protein S6 kinase, polypeptide 21, 5 87.72(n)1
    95.63(a)1
      17 (4.70 cM)5
    201121  NM_011299.41  NP_035429.11 
     71701155 
    chicken
    (Gallus gallus)
    Aves RPS6KA21 ribosomal protein S6 kinase, 90kDa, polypeptide 2 81.63(n)
    94.13(a)
      421570  XM_419611.3  XP_419611.2 
    lizard
    (Anolis carolinensis)
    Reptilia RPS6KA26
    ribosomal protein S6 kinase, 90kDa, polypeptide 2
    91(a)
    1 ↔ 1
    1(225719585-225890028)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rps6ka21 ribosomal protein S6 kinase, 90kDa, polypeptide 2 73.99(n)
    87.5(a)
      100495717  XM_002942350.2  XP_002942396.2 
    zebrafish
    (Danio rerio)
    Actinopterygii rps6ka21 ribosomal protein S6 kinase, 90kDa, polypeptide 2 75.76(n)
    89.09(a)
      571285  XM_694860.4  XP_699952.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta S6kII3 protein amino acid phosphorylation
    protein serine/threonine more
    58(a)
    (best of 2)
      20B1   --
    worm
    (Caenorhabditis elegans)
    Secernentea T01H8.1b3 Protein kinase C terminal domain 62(a)
    (best of 3)
      I(8582453-8585937)   --
    soybean
    (Glycine max)
    eudicotyledons Gma.1862 Glycine max SOS2-like protein kinase mRNA, complete more 70.03(n)    AF525402.1 
    rice
    (Oryza sativa)
    Liliopsida Os.61262 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 72.94(n)    AK067266.1 


    ENSEMBL Gene Tree for RPS6KA2 (if available)
    TreeFam Gene Tree for RPS6KA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RPS6KA2 gene
    RPS6KA62  MAPKAPK32  MAPKAPK52  RPS6KA12  RPS6KA52  MAPKAPK22  RPS6KA42  MKNK12  
    MKNK22  RPS6KA32  
    Selected SIMAP similar genes for RPS6KA2 using alignment to 9 protein entries:     KS6A2_HUMAN (see all proteins) (see all similar genes):
    RPS6KA3    RPS6KA1    RPS6KA6    KIN27    CIT    PRKACB
    PRKACA    RPS6KB2    PKN2    PRKCE    RPS6KB1    RPS6KA5
    SGK494    PRKCA    SGK2    DKFZp564L2416    PRKACG    PRKG2

    RPS6KA2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RPS6KA2 (see all 10887)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0406274
    A metastatic melanoma sample4--see VAR_0406272 E K mis40--------
    VAR_0406284
    A colorectal adenocarcinoma sample4--see VAR_0406282 R Q mis40--------
    rs1129588741,2
    C--166822387(+) TGCACAT/-GTTTA 2 -- ds50011Minor allele frequency- -:0.50CSA 2
    rs1167768501,2
    F--166822449(+) ACACAC/TGTACA 2 -- ds50011Minor allele frequency- T:0.02WA 118
    rs69237311,2
    C,F--166822450(+) cacacG/Atacac 2 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1155207491,2
    F--166822469(+) ATGCAT/CGAACT 2 -- ds50011Minor allele frequency- C:0.03WA 118
    rs599245951,2
    C--166822519(+) CACAC-/ACTCATG 2 -- ds50010--------
    rs1476623821,2
    --166822540(+) CACCCA/GCCTAC 2 -- ds50010--------
    rs724639631,2
    C--166822560(+) CATGT-/GCAC  
      ACACAA
    GCACA
    2 -- ds50010--------
    rs3724466451,2
    C--166822571(+) CACAA-/CAACACA 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for RPS6KA2 (166822852 - 167072852 bp, first 250kb of RPS6KA2)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RPS6KA2 (see all 58):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1538758CNV Deletion17803354
    esv2182887CNV Deletion18987734
    esv2678517CNV Deletion23128226
    esv2666760CNV Deletion23128226
    esv2733191CNV Deletion23290073
    esv3720CNV Deletion18987735
    esv2733198CNV Deletion23290073
    esv2580547CNV Deletion19546169
    esv2733202CNV Deletion23290073
    esv2733201CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601685    OMIM disorders: --

    Selected diseases for RPS6KA2 (see all 21):    
    About MalaCards
    myiasis    coffin-lowry syndrome    subacute sclerosing panencephalitis    prostate cancer
    dental caries    prostatitis    endocarditis    gout
    measles    pulmonary function    labyrinthitis    inflammatory bowel disease
    myeloid leukemia    ovarian cancer    thyroiditis    lung cancer
    leukemia    hepatitis    breast cancer    cerebritis


    RPS6KA2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for RPS6KA2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 1 16878154 (1)

    Genetic Association Database (GAD): RPS6KA2
    Human Genome Epidemiology (HuGE) Navigator: RPS6KA2 (3 documents)

    Export disorders for RPS6KA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RPS6KA2 gene, integrated from 10 sources (see all 77):
    (articles sorted by number of sources associating them with RPS6KA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human rsk isoforms: cloning and characterization of tissue-specific expression. (PubMed id 8141249)1, 2, 3, 9 Moller D.E.... Jakubowski M. (Am. J. Physiol. 1994)
    2. RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation. (PubMed id 7623830)1, 2, 9 Zhao Y.... Moller D.E. (Mol. Cell. Biol. 1995)
    3. RPS6KA2, a putative tumour suppressor gene at 6q27 in sporadic epithelial ovarian cancer. (PubMed id 16878154)1, 2, 9 Bignone P.A.... Ganesan T.S. (Oncogene 2007)
    4. 90-kDa ribosomal S6 kinase is phosphorylated and activated by 3- phosphoinositide-dependent protein kinase-1. (PubMed id 10480933)1, 2, 9 Jensen C.J....Froedin M. (J. Biol. Chem. 1999)
    5. Genetic variation in RPS6KA1, RPS6KA2, RPS6KB1, RPS6KB2, and PDK1 and risk of colon or rectal cancer. (PubMed id 21035469)1, 4 Slattery M.L....Wolff R.K. (Mutat. Res. 2011)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)1, 2 Denis N.J.... Figeys D. (Proteomics 2007)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6196 HGNC: 10431 AceView: RNASET2andRPS6KA2 Ensembl:ENSG00000071242 euGenes: HUgn6196
    ECgene: RPS6KA2 Kegg: 6196 H-InvDB: RPS6KA2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RPS6KA2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RPS6KA2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RPS6KA2 gene:
    Search GeneIP for patents involving RPS6KA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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