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Aliases for RPS6KA2 Gene

Aliases for RPS6KA2 Gene

  • Ribosomal Protein S6 Kinase A2 2 3
  • Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 2 3 5
  • MAP Kinase-Activated Protein Kinase 1c 3 4
  • MAPK-Activated Protein Kinase 1c 3 4
  • Ribosomal S6 Kinase 3 3 4
  • EC 2.7.11.1 4 63
  • MAPKAPK1C 3 4
  • Pp90RSK3 3 4
  • P90RSK2 3 4
  • RSK3 3 4
  • Mitogen-Activated Protein Kinase-Activated Protein Kinase 1C 3
  • Ribosomal Protein S6 Kinase, 90kD, Polypeptide 2 2
  • 90 KDa Ribosomal Protein S6 Kinase 2 4
  • MAPKAP Kinase 1C 3
  • MAPKAP Kinase 1c 4
  • S6K-Alpha-2 4
  • S6K-Alpha2 3
  • MAPKAPK-1c 4
  • S6K-Alpha 3
  • P90-RSK 2 4
  • EC 2.7.11 63
  • P90-RSK3 3
  • RSK-3 4
  • HU-2 3
  • RSK 3

External Ids for RPS6KA2 Gene

Previous GeneCards Identifiers for RPS6KA2 Gene

  • GC06M166179
  • GC06M166698
  • GC06M166734
  • GC06M166733
  • GC06M166795
  • GC06M166742
  • GC06M164294
  • GC06M166822

Summaries for RPS6KA2 Gene

Entrez Gene Summary for RPS6KA2 Gene

  • This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains two non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternative splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jan 2016]

GeneCards Summary for RPS6KA2 Gene

RPS6KA2 (Ribosomal Protein S6 Kinase A2) is a Protein Coding gene. Among its related pathways are MyD88 cascade initiated on plasma membrane and Development Dopamine D2 receptor transactivation of EGFR. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AKT1.

UniProtKB/Swiss-Prot for RPS6KA2 Gene

  • Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.

Tocris Summary for RPS6KA2 Gene

  • Ribosomal S6 protein kinases (RSKs) are a family of protein serine/threonine kinases that regulate diverse cellular processes such as cellular growth, motility, survival and proliferation. The RSK family can be divided into two subfamilies, namely p90 RSK and p70 S6K.

Gene Wiki entry for RPS6KA2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS6KA2 Gene

Genomics for RPS6KA2 Gene

Regulatory Elements for RPS6KA2 Gene

Enhancers for RPS6KA2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPS6KA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPS6KA2 Gene

Chromosome:
6
Start:
166,409,364 bp from pter
End:
166,906,451 bp from pter
Size:
497,088 bases
Orientation:
Minus strand

Genomic View for RPS6KA2 Gene

Genes around RPS6KA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS6KA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS6KA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS6KA2 Gene

Proteins for RPS6KA2 Gene

  • Protein details for RPS6KA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15349-KS6A2_HUMAN
    Recommended name:
    Ribosomal protein S6 kinase alpha-2
    Protein Accession:
    Q15349
    Secondary Accessions:
    • B3KTK9
    • Q15419
    • Q59GJ3
    • Q5TI68
    • Q96J38
    • Q9UJN5

    Protein attributes for RPS6KA2 Gene

    Size:
    733 amino acids
    Molecular mass:
    83239 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells. Transiently dissociates following mitogenic stimulation (By similarity).
    SequenceCaution:
    • Sequence=AAC82496.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAD92353.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG53121.1; Type=Frameshift; Positions=527; Evidence={ECO:0000305};

    Alternative splice isoforms for RPS6KA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPS6KA2 Gene

Proteomics data for RPS6KA2 Gene at MOPED

Post-translational modifications for RPS6KA2 Gene

  • Activated by phosphorylation at Ser-218 by PDPK1. Autophosphorylated on Ser-377, as part of the activation process. May be phosphorylated at Thr-356 and Ser-360 by MAPK1/ERK2 and MAPK3/ERK1 (By similarity).
  • N-terminal myristoylation results in an activated kinase in the absence of added growth factors.
  • Ubiquitination at Lys 630
  • Modification sites at PhosphoSitePlus

Domains & Families for RPS6KA2 Gene

Suggested Antigen Peptide Sequences for RPS6KA2 Gene

Graphical View of Domain Structure for InterPro Entry

Q15349

UniProtKB/Swiss-Prot:

KS6A2_HUMAN :
  • Contains 1 AGC-kinase C-terminal domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
Domain:
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 2 protein kinase domains.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
genes like me logo Genes that share domains with RPS6KA2: view

Function for RPS6KA2 Gene

Molecular function for RPS6KA2 Gene

GENATLAS Biochemistry:
ribosomal S6 kinase,90kDa,polypeptide 2,growth factor regulated serine/threonine kinase family,predominantly expressed in lung and skeletal muscle,not involved in vivo in the phosphorylation of RPS6,mediating protein synthesis initiation and elongation induced by hormones or growth factors,maybe playing an essentilal regulatory role in protein synthesis during cell proliferation
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Upon extracellular signal or mitogen stimulation, phosphorylated at Thr-570 in the C-terminal kinase domain (CTKD) by MAPK1/ERK2 and MAPK3/ERK1. The activated CTKD then autophosphorylates Ser-377, allowing binding of PDPK1, which in turn phosphorylates Ser-218 in the N-terminal kinase domain (NTDK) leading to the full activation of the protein and subsequent phosphorylation of the substrates by the NTKD.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.

Enzyme Numbers (IUBMB) for RPS6KA2 Gene

Gene Ontology (GO) - Molecular Function for RPS6KA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with RPS6KA2: view
genes like me logo Genes that share phenotypes with RPS6KA2: view

Animal Models for RPS6KA2 Gene

MGI Knock Outs for RPS6KA2:

Animal Model Products

  • Taconic Biosciences Mouse Models for RPS6KA2

CRISPR Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RPS6KA2 Gene

Localization for RPS6KA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS6KA2 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS6KA2 Gene COMPARTMENTS Subcellular localization image for RPS6KA2 gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 3
plasma membrane 3
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for RPS6KA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with RPS6KA2: view

Pathways & Interactions for RPS6KA2 Gene

SuperPathways for RPS6KA2 Gene

Superpath Contained pathways
1 MyD88 cascade initiated on plasma membrane
2 Post NMDA receptor activation events
3 MAPK targets/ Nuclear events mediated by MAP kinases
4 mTOR Pathway
5 GDNF-Family Ligands and Receptor Interactions
genes like me logo Genes that share pathways with RPS6KA2: view

SIGNOR curated interactions for RPS6KA2 Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for RPS6KA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001556 oocyte maturation IEA --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction NAS 7623830
genes like me logo Genes that share ontologies with RPS6KA2: view

Drugs & Compounds for RPS6KA2 Gene

(7) Drugs for RPS6KA2 Gene - From: ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Kaempferol Experimental Pharma Apoptosis inducer;antioxidant;flavonoid, Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter 0
PF-4708671 Pharma P70 S6K1 isoform inhibitor,cell-permeable, S6K1 inhibitor 0
BI-D1870 Pharma P90 RSK inhibitor,ATP-competitive and cell-permeable 0
Magnesium Nutra 0
Rapamycin Pharma mTOR inhibitor, mTOR inhibitor; immunosuppressant 0

(2) Additional Compounds for RPS6KA2 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
BRD 7389
376382-11-5
SL 0101-1
77307-50-7

(5) Tocris Compounds for RPS6KA2 Gene

Compound Action Cas Number
BRD 7389 Ribosomal S6 kinase inhibitor 376382-11-5
Kaempferol Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter 520-18-3
PF 4708671 S6K1 inhibitor 1255517-76-0
Rapamycin mTOR inhibitor; immunosuppressant 53123-88-9
SL 0101-1 Selective ribosomal S6 kinase (RSK) inhibitor 77307-50-7

(2) ApexBio Compounds for RPS6KA2 Gene

Compound Action Cas Number
BI-D1870 P90 RSK inhibitor,ATP-competitive and cell-permeable 501437-28-1
PF-4708671 P70 S6K1 isoform inhibitor,cell-permeable 1255517-76-0
genes like me logo Genes that share compounds with RPS6KA2: view

Transcripts for RPS6KA2 Gene

Unigene Clusters for RPS6KA2 Gene

Ribosomal protein S6 kinase, 90kDa, polypeptide 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPS6KA2 Gene

No ASD Table

Relevant External Links for RPS6KA2 Gene

GeneLoc Exon Structure for
RPS6KA2
ECgene alternative splicing isoforms for
RPS6KA2

Expression for RPS6KA2 Gene

mRNA expression in normal human tissues for RPS6KA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPS6KA2 Gene

This gene is overexpressed in Brain (21.3), Adipocyte (14.3), and Frontal cortex (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS6KA2 Gene



SOURCE GeneReport for Unigene cluster for RPS6KA2 Gene Hs.655277

mRNA Expression by UniProt/SwissProt for RPS6KA2 Gene

Q15349-KS6A2_HUMAN
Tissue specificity: Widely expressed with higher expression in lung, skeletal muscle, brain, uterus, ovary, thyroid and prostate.
genes like me logo Genes that share expression patterns with RPS6KA2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for RPS6KA2 Gene

Orthologs for RPS6KA2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS6KA2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPS6KA2 35
  • 88.86 (n)
  • 96.86 (a)
RPS6KA2 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPS6KA2 35
  • 89.25 (n)
  • 97 (a)
RPS6KA2 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rps6ka2 35
  • 87.72 (n)
  • 95.63 (a)
Rps6ka2 16
Rps6ka2 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPS6KA2 35
  • 95.32 (n)
  • 94.99 (a)
RPS6KA2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rps6ka2 35
  • 86.99 (n)
  • 95.63 (a)
oppossum
(Monodelphis domestica)
Mammalia RPS6KA2 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 87 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
chicken
(Gallus gallus)
Aves RPS6KA2 35
  • 81.63 (n)
  • 94.13 (a)
RPS6KA2 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPS6KA2 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rps6ka2 35
  • 73.99 (n)
  • 87.5 (a)
zebrafish
(Danio rerio)
Actinopterygii rps6ka2 35
  • 75.76 (n)
  • 89.09 (a)
RPS6KA2 36
  • 86 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Pk17E 37
  • 41 (a)
S6kII 37
  • 58 (a)
S6kII 36
  • 48 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F28C10.3 37
  • 36 (a)
R04A9.5 37
  • 44 (a)
T01H8.1b 37
  • 62 (a)
rskn-1 36
  • 53 (a)
OneToMany
soybean
(Glycine max)
eudicotyledons Gma.186 35
rice
(Oryza sativa)
Liliopsida Os.6126 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 68 (a)
OneToMany
Species with no ortholog for RPS6KA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS6KA2 Gene

ENSEMBL:
Gene Tree for RPS6KA2 (if available)
TreeFam:
Gene Tree for RPS6KA2 (if available)

Paralogs for RPS6KA2 Gene

(229) SIMAP similar genes for RPS6KA2 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with RPS6KA2: view

Variants for RPS6KA2 Gene

Sequence variations from dbSNP and Humsavar for RPS6KA2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_040627 A metastatic melanoma sample
VAR_040628 A colorectal adenocarcinoma sample
rs1012895 -- 166,435,160(-) CAGCC(A/G)TCTGT intron-variant
rs1012896 -- 166,434,837(-) GATGG(C/T)GTAGG intron-variant
rs1016105 -- 166,486,662(-) GATGG(A/T)CCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPS6KA2 Gene

Variant ID Type Subtype PubMed ID
esv2485852 CNV Insertion 19546169
esv1684843 CNV Insertion 17803354
nsv886937 CNV Loss 21882294
nsv823928 CNV Loss 20364138
esv2733185 CNV Deletion 23290073
dgv7035n71 CNV Loss 21882294
esv2733186 CNV Deletion 23290073
esv2733187 CNV Deletion 23290073
esv2733188 CNV Deletion 23290073
esv2733189 CNV Deletion 23290073
nsv886940 CNV Loss 21882294
dgv400n21 CNV Loss 19592680
nsv7388 OTHER Inversion 18451855
esv2678517 CNV Deletion 23128226
esv2733190 CNV Deletion 23290073
nsv886941 CNV Loss 21882294
nsv5591 CNV Insertion 18451855
nsv5592 CNV Loss 18451855
esv2733191 CNV Deletion 23290073
esv2580547 CNV Deletion 19546169
esv2182887 CNV Deletion 18987734
dgv1170e199 CNV Deletion 23128226
nsv349126 CNV Loss 16902084
esv23654 CNV Loss 19812545
esv2733192 CNV Deletion 23290073
esv2733193 CNV Deletion 23290073
esv2672309 CNV Deletion 23128226
esv2733194 CNV Deletion 23290073
esv3720 CNV Deletion 18987735
esv22598 CNV Loss 19812545
esv7295 CNV Gain 19470904
esv272233 CNV Insertion 20981092
esv267636 CNV Insertion 20981092
esv1742910 CNV Insertion 17803354
esv271508 CNV Insertion 20981092
esv25052 CNV Loss 19812545
esv29465 CNV Gain+Loss 19812545
esv2507832 CNV Deletion 19546169
esv2733196 CNV Deletion 23290073
esv2733197 CNV Deletion 23290073
esv2733198 CNV Deletion 23290073
esv2733199 CNV Deletion 23290073
esv2733200 CNV Deletion 23290073
esv2677188 CNV Deletion 23128226
esv269075 CNV Insertion 20981092
esv2733201 CNV Deletion 23290073
esv24794 CNV Gain+Loss 19812545
esv2662308 CNV Deletion 23128226
esv2666760 CNV Deletion 23128226
esv1965634 CNV Deletion 18987734
nsv518561 CNV Loss 19592680
nsv886942 CNV Loss 21882294
esv2673126 CNV Deletion 23128226
esv2733202 CNV Deletion 23290073
esv2733203 CNV Deletion 23290073
esv1002461 CNV Deletion 20482838
esv1538758 CNV Deletion 17803354
nsv348883 CNV Loss 16902084

Variation tolerance for RPS6KA2 Gene

Residual Variation Intolerance Score: 2.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.23% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RPS6KA2 Gene

Disorders for RPS6KA2 Gene

Relevant External Links for RPS6KA2

Genetic Association Database (GAD)
RPS6KA2
Human Genome Epidemiology (HuGE) Navigator
RPS6KA2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPS6KA2

No disorders were found for RPS6KA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPS6KA2 Gene

Publications for RPS6KA2 Gene

  1. Human rsk isoforms: cloning and characterization of tissue-specific expression. (PMID: 8141249) Moller D.E. … Jakubowski M. (Am. J. Physiol. 1994) 2 3 4 23 67
  2. RPS6KA2, a putative tumour suppressor gene at 6q27 in sporadic epithelial ovarian cancer. (PMID: 16878154) Bignone P.A. … Ganesan T.S. (Oncogene 2007) 3 23
  3. Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity. (PMID: 12832467) Roux P.P. … Blenis J. (Mol. Cell. Biol. 2003) 3 23
  4. Expression analysis of RSK gene family members: the RSK2 gene, mutated in Coffin-Lowry syndrome, is prominently expressed in brain structures essential for cognitive function and learning. (PMID: 12393804) Zeniou M. … Hanauer A. (Hum. Mol. Genet. 2002) 3 23
  5. MEK, ERK, and p90RSK are present on mitotic tubulin in Swiss 3T3 cells: a role for the MAP kinase pathway in regulating mitotic exit. (PMID: 11495723) Willard F.S. … Crouch M.F. (Cell. Signal. 2001) 3 23

Products for RPS6KA2 Gene

Sources for RPS6KA2 Gene

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