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Aliases for RPS6KA1 Gene

Aliases for RPS6KA1 Gene

  • Ribosomal Protein S6 Kinase A1 2 3
  • Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 3 5
  • MAP Kinase-Activated Protein Kinase 1a 3 4
  • 90 KDa Ribosomal Protein S6 Kinase 1 3 4
  • MAPK-Activated Protein Kinase 1a 3 4
  • Ribosomal S6 Kinase 1 3 4
  • MAPKAP Kinase 1a 3 4
  • S6K-Alpha-1 3 4
  • EC 2.7.11.1 4 63
  • MAPKAPK-1a 3 4
  • P90-RSK 1 3 4
  • MAPKAPK1A 3 4
  • P90RSK1 3 4
  • P90S6K 3 4
  • RSK-1 3 4
  • RSK1 3 4
  • DJ590P13.1 (Ribosomal Protein S6 Kinase, 90kD, Polypeptide 1) 3
  • Ribosomal Protein S6 Kinase, 90kD, Polypeptide 1 2
  • Ribosomal Protein S6 Kinase Alpha 1 3
  • S6K-Alpha 1 3
  • EC 2.7.11 63
  • P90Rsk 3
  • HU-1 3
  • RSK 3

External Ids for RPS6KA1 Gene

Previous GeneCards Identifiers for RPS6KA1 Gene

  • GC01P028654
  • GC01P025888
  • GC01P026089
  • GC01P026460
  • GC01P026728
  • GC01P026856
  • GC01P025110

Summaries for RPS6KA1 Gene

Entrez Gene Summary for RPS6KA1 Gene

  • This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS6KA1 Gene

RPS6KA1 (Ribosomal Protein S6 Kinase A1) is a Protein Coding gene. Diseases associated with RPS6KA1 include coffin-lowry syndrome and hemorrhoid. Among its related pathways are Translation Insulin regulation of translation and Post NMDA receptor activation events. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AKT1.

UniProtKB/Swiss-Prot for RPS6KA1 Gene

  • Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at Ser-9 and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex. In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at Ser-1798, which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (By similarity). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression.

Tocris Summary for RPS6KA1 Gene

  • Ribosomal S6 protein kinases (RSKs) are a family of protein serine/threonine kinases that regulate diverse cellular processes such as cellular growth, motility, survival and proliferation. The RSK family can be divided into two subfamilies, namely p90 RSK and p70 S6K.

Gene Wiki entry for RPS6KA1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS6KA1 Gene

Genomics for RPS6KA1 Gene

Regulatory Elements for RPS6KA1 Gene

Enhancers for RPS6KA1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPS6KA1 on UCSC Golden Path with GeneCards custom track

Promoters for RPS6KA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPS6KA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPS6KA1 Gene

Chromosome:
1
Start:
26,529,758 bp from pter
End:
26,575,030 bp from pter
Size:
45,273 bases
Orientation:
Plus strand

Genomic View for RPS6KA1 Gene

Genes around RPS6KA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS6KA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS6KA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS6KA1 Gene

Proteins for RPS6KA1 Gene

  • Protein details for RPS6KA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15418-KS6A1_HUMAN
    Recommended name:
    Ribosomal protein S6 kinase alpha-1
    Protein Accession:
    Q15418
    Secondary Accessions:
    • A6NGG4
    • A8K9K7
    • B2RDY8
    • B7Z5J0
    • E9PRI4
    • Q5SVM5
    • Q5SVM8
    • Q5SVM9
    • Q96C05
    • Q9BQK2

    Protein attributes for RPS6KA1 Gene

    Size:
    735 amino acids
    Molecular mass:
    82723 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells. Transiently dissociates following mitogenic stimulation. Interacts with ETV1/ER81 and FGFR1.

    Three dimensional structures from OCA and Proteopedia for RPS6KA1 Gene

    Alternative splice isoforms for RPS6KA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPS6KA1 Gene

Proteomics data for RPS6KA1 Gene at MOPED

Post-translational modifications for RPS6KA1 Gene

  • Activated by phosphorylation at Ser-221 by PDPK1. Autophosphorylated on Ser-380, as part of the activation process. May be phosphorylated at Thr-359 and Ser-363 by MAPK1/ERK2 and MAPK3/ERK1.
  • N-terminal myristoylation results in an activated kinase in the absence of added growth factors.
  • Ubiquitination at Lys 66, Lys 278, and Lys 316
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RPS6KA1 (p90RSK)

Domains & Families for RPS6KA1 Gene

Graphical View of Domain Structure for InterPro Entry

Q15418

UniProtKB/Swiss-Prot:

KS6A1_HUMAN :
  • Contains 1 AGC-kinase C-terminal domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
Domain:
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 2 protein kinase domains.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
genes like me logo Genes that share domains with RPS6KA1: view

Function for RPS6KA1 Gene

Molecular function for RPS6KA1 Gene

GENATLAS Biochemistry:
ribosomal protein S6 kinase,polypeptide 1,not involved in vivo in the phosphorylation of RPS6,mediating protein synthesis initiation and elongation induced by hormones or growth factors,maybe playing an essentilal regulatory role in protein synthesis during cell proliferation
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Upon extracellular signal or mitogen stimulation, phosphorylated at Thr-573 in the C-terminal kinase domain (CTKD) by MAPK1/ERK2 and MAPK3/ERK1. The activated CTKD then autophosphorylates Ser-380, allowing binding of PDPK1, which in turn phosphorylates Ser-221 in the N-terminal kinase domain (NTDK) leading to the full activation of the protein and subsequent phosphorylation of the substrates by the NTKD.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at Ser-9 and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex. In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at Ser-1798, which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (By similarity). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression.

Enzyme Numbers (IUBMB) for RPS6KA1 Gene

Gene Ontology (GO) - Molecular Function for RPS6KA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA 18402937
genes like me logo Genes that share ontologies with RPS6KA1: view
genes like me logo Genes that share phenotypes with RPS6KA1: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS6KA1 Gene

Localization for RPS6KA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS6KA1 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS6KA1 Gene COMPARTMENTS Subcellular localization image for RPS6KA1 gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 3
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
plasma membrane 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for RPS6KA1 Gene

Pathways & Interactions for RPS6KA1 Gene

SuperPathways for RPS6KA1 Gene

Superpath Contained pathways
1 MyD88 cascade initiated on plasma membrane
2 Post NMDA receptor activation events
3 Translation Insulin regulation of translation
4 MAPK targets/ Nuclear events mediated by MAP kinases
5 GDNF-Family Ligands and Receptor Interactions
genes like me logo Genes that share pathways with RPS6KA1: view

SIGNOR curated interactions for RPS6KA1 Gene

Gene Ontology (GO) - Biological Process for RPS6KA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction TAS 8141249
GO:0007268 synaptic transmission TAS --
genes like me logo Genes that share ontologies with RPS6KA1: view

Drugs & Compounds for RPS6KA1 Gene

(14) Drugs for RPS6KA1 Gene - From: DrugBank, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Purvalanol A Experimental Pharma Target Cyclin-dependent kinase inhibitor 0
Kaempferol Experimental Pharma Apoptosis inducer;antioxidant;flavonoid, Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter 0
PF-4708671 Pharma P70 S6K1 isoform inhibitor,cell-permeable, S6K1 inhibitor 0
Rapamycin Pharma mTOR inhibitor, mTOR inhibitor; immunosuppressant 0

(9) Additional Compounds for RPS6KA1 Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
BRD 7389
376382-11-5
SL 0101-1
77307-50-7

(5) Tocris Compounds for RPS6KA1 Gene

Compound Action Cas Number
BRD 7389 Ribosomal S6 kinase inhibitor 376382-11-5
Kaempferol Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter 520-18-3
PF 4708671 S6K1 inhibitor 1255517-76-0
Rapamycin mTOR inhibitor; immunosuppressant 53123-88-9
SL 0101-1 Selective ribosomal S6 kinase (RSK) inhibitor 77307-50-7

(2) ApexBio Compounds for RPS6KA1 Gene

Compound Action Cas Number
BI-D1870 P90 RSK inhibitor,ATP-competitive and cell-permeable 501437-28-1
PF-4708671 P70 S6K1 isoform inhibitor,cell-permeable 1255517-76-0
genes like me logo Genes that share compounds with RPS6KA1: view

Transcripts for RPS6KA1 Gene

Unigene Clusters for RPS6KA1 Gene

Ribosomal protein S6 kinase, 90kDa, polypeptide 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPS6KA1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^
SP1: - - - - - -
SP2: - - -
SP3: - -
SP4:
SP5: -
SP6:
SP7:

ExUns: 23 ^ 24 ^ 25 ^ 26
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for RPS6KA1 Gene

GeneLoc Exon Structure for
RPS6KA1
ECgene alternative splicing isoforms for
RPS6KA1

Expression for RPS6KA1 Gene

mRNA expression in normal human tissues for RPS6KA1 Gene

mRNA differential expression in normal tissues according to GTEx for RPS6KA1 Gene

This gene is overexpressed in Whole Blood (x21.5).

Protein differential expression in normal tissues from HIPED for RPS6KA1 Gene

This gene is overexpressed in Lymph node (11.8), Stomach (7.0), Peripheral blood mononuclear cells (7.0), and Salivary gland (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS6KA1 Gene



SOURCE GeneReport for Unigene cluster for RPS6KA1 Gene Hs.149957

genes like me logo Genes that share expression patterns with RPS6KA1: view

Protein tissue co-expression partners for RPS6KA1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for RPS6KA1 Gene

Orthologs for RPS6KA1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RPS6KA1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPS6KA1 35
  • 92.38 (n)
  • 99.05 (a)
RPS6KA1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPS6KA1 35
  • 91.09 (n)
  • 96.56 (a)
RPS6KA1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rps6ka1 35
  • 91.02 (n)
  • 98.5 (a)
Rps6ka1 16
Rps6ka1 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPS6KA1 35
  • 99.82 (n)
  • 100 (a)
RPS6KA1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rps6ka1 35
  • 90.16 (n)
  • 97.55 (a)
oppossum
(Monodelphis domestica)
Mammalia RPS6KA1 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPS6KA1 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPS6KA1 35
  • 80.84 (n)
  • 92.23 (a)
RPS6KA 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 69 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rps6ka1 35
  • 73.49 (n)
  • 85.95 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.856 35
zebrafish
(Danio rerio)
Actinopterygii rps6ka3a 35
  • 70.55 (n)
  • 77.95 (a)
rps6ka1 36
  • 80 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Pk17E 37
  • 42 (a)
S6kII 37
  • 57 (a)
S6kII 36
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F28C10.3 37
  • 36 (a)
R04A9.5 37
  • 45 (a)
T01H8.1b 37
  • 63 (a)
rskn-1 35
  • 58.97 (n)
  • 62.73 (a)
rskn-1 36
  • 55 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIN82 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 69 (a)
OneToMany
Species with no ortholog for RPS6KA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS6KA1 Gene

ENSEMBL:
Gene Tree for RPS6KA1 (if available)
TreeFam:
Gene Tree for RPS6KA1 (if available)

Paralogs for RPS6KA1 Gene

genes like me logo Genes that share paralogs with RPS6KA1: view

Variants for RPS6KA1 Gene

Sequence variations from dbSNP and Humsavar for RPS6KA1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2229712 - 26,557,020(+) GATCA(A/C)GCCAC reference, missense
rs7726 -- 26,574,828(+) CCCCT(A/G)CGGTC utr-variant-3-prime
rs11113 -- 26,574,599(+) CCCCA(C/T)GATTG utr-variant-3-prime
rs14071 -- 26,574,610(-) CTACA(A/G)GTGGC utr-variant-3-prime
rs188158 -- 26,571,651(-) TCCAA(C/G/T)TCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPS6KA1 Gene

Variant ID Type Subtype PubMed ID
dgv202n71 CNV Loss 21882294
nsv526179 CNV Gain 19592680

Variation tolerance for RPS6KA1 Gene

Residual Variation Intolerance Score: 14.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.35; 81.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS6KA1 Gene

HapMap Linkage Disequilibrium report
RPS6KA1
Human Gene Mutation Database (HGMD)
RPS6KA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS6KA1 Gene

Disorders for RPS6KA1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for RPS6KA1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
coffin-lowry syndrome
  • cls
hemorrhoid
  • hemorrhoidal disease
tuberous sclerosis
  • bourneville's disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RPS6KA1

Genetic Association Database (GAD)
RPS6KA1
Human Genome Epidemiology (HuGE) Navigator
RPS6KA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPS6KA1
genes like me logo Genes that share disorders with RPS6KA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS6KA1 Gene

Publications for RPS6KA1 Gene

  1. Human rsk isoforms: cloning and characterization of tissue-specific expression. (PMID: 8141249) Moller D.E. … Jakubowski M. (Am. J. Physiol. 1994) 2 3 4 23 67
  2. p90 ribosomal S6 kinase 1 (RSK1) and the catalytic subunit of protein kinase A (PKA) compete for binding the pseudosubstrate region of PKAR1alpha: role in the regulation of PKA and RSK1 activities. (PMID: 20048145) Gao X. … Patel T.B. (J. Biol. Chem. 2010) 3 23
  3. RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility. (PMID: 19470470) Larrea M.D. … Slingerland J.M. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23
  4. Phosphorylation of Nur77 by the MEK-ERK-RSK cascade induces mitochondrial translocation and apoptosis in T cells. (PMID: 19675165) Wang A. … Osborne B.A. (J. Immunol. 2009) 3 23
  5. Regulation of protein kinase A activity by p90 ribosomal S6 kinase 1. (PMID: 19808666) Gao X. … Patel T.B. (J. Biol. Chem. 2009) 3 23

Products for RPS6KA1 Gene

Sources for RPS6KA1 Gene

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