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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPS6KA1 Gene

protein-coding   GIFtS: 73
GCID: GC01P026856

Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1

(Previous names: ribosomal protein S6 kinase, 90kD, polypeptide 1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 11 2     p90RSK12 3
RSK12 3 5     p90S6K2 3
Ribosomal S6 Kinase 12 3     EC 2.7.11.13 8
90 KDa Ribosomal Protein S6 Kinase 12 3     Ribosomal Protein S6 Kinase, 90kD, Polypeptide 11
MAPKAPK-1a2 3     HU-12
MAPKAPK1A2 3     RSK2
RSK-12 3     DJ590P13.1 (Ribosomal Protein S6 Kinase, 90kD, Polypeptide 1)2
S6K-alpha-12 3     Ribosomal Protein S6 Kinase Alpha 12
MAP Kinase-Activated Protein Kinase 1a2 3     Ribosomal Protein S6 Kinase Alpha-12
MAPK-Activated Protein Kinase 1a2 3     S6K-Alpha 12
MAPKAP Kinase 1a2 3     EC 2.7.118
P90-RSK 12 3     

External Ids:    HGNC: 104301   Entrez Gene: 61952   Ensembl: ENSG000001176767   OMIM: 6016845   UniProtKB: Q154183   

Export aliases for RPS6KA1 gene to outside databases

Previous GC identifers: GC01P028654 GC01P025888 GC01P026089 GC01P026460 GC01P026540 GC01P026728 GC01P025110


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RPS6KA1 Gene:
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase
contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the
mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in
controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different
isoforms, have been characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for RPS6KA1 Gene: 
RPS6KA1 (ribosomal protein S6 kinase, 90kDa, polypeptide 1) is a protein-coding gene. Diseases associated with RPS6KA1 include coffin-lowry syndrome, and tuberous sclerosis complex, and among its related super-pathways are GDNF-Family Ligands and Receptor Interactions and Transcription Receptor-mediated HIF regulation. GO annotations related to this gene include protein serine/threonine kinase activity and cysteine-type endopeptidase inhibitor activity involved in apoptotic process. An important paralog of this gene is RPS6KA6.

UniProtKB/Swiss-Prot: KS6A1_HUMAN, Q15418
Function: Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and
mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77,
regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and
differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In
fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent
transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA),
phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon
insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B
at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent
mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex. In response
to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent
translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798',
which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which
regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway.
Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their
pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to
the hepatotoxin carbon tetrachloride (CCl4). Is involved in cell cycle regulation by phosphorylating the CDK
inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the
nucleus and inhibition of G1 progression

summary for RPS6KA1 Gene:
p90 ribosomal S6 kinases (RSKs) are a family of protein serine/threonine kinases that regulate diverse
cellular processes such as cell growth, motility, survival and proliferation. There are four isoforms of
this enzyme; RSK1-4, which are directly activated by ERK1/2 in response to growth factors, many polypeptide
hormones, neurotransmitters and chemokines. p90 RSKs phosphorylate numerous cytosolic and nuclear targets
and act as downstream effectors of the ERK/MAPK signaling cascade. They are expressed ubiquitously in human
tissues and exist in multiple subcellular compartments. Abberant activation of p90 RSKs has been linked to
many human diseases, including breast and prostate cancers.

Gene Wiki entry for RPS6KA1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004610.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPS6KA1 gene promoter:
         C/EBPbeta   Elk-1   NF-kappaB   NF-kappaB1   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RPS6KA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RPS6KA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS6KA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p

RPS6KA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS6KA1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P026856:  view genomic region     (about GC identifiers)

Start:
26,856,249 bp from pter      End:
26,901,521 bp from pter
Size:
45,273 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KS6A1_HUMAN, Q15418 (See protein sequence)
Recommended Name: Ribosomal protein S6 kinase alpha-1  
Size: 735 amino acids; 82723 Da
Cofactor: Magnesium
Subunit: Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells. Transiently dissociates
following mitogenic stimulation. Interacts with ETV1/ER81 and FGFR1
Subcellular location: Nucleus. Cytoplasm
6/7 PDB 3D structures from and Proteopedia for RPS6KA1 (see all 7):
2WNT (3D)        2Z7Q (3D)        2Z7R (3D)        2Z7S (3D)        3RNY (3D)        3TEI (3D)    
Secondary accessions: A6NGG4 A8K9K7 B2RDY8 B7Z5J0 Q5SVM5 Q5SVM8 Q5SVM9 Q96C05 Q9BQK2
Alternative splicing: 3 isoforms:  Q15418-1   Q15418-2   Q15418-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RPS6KA1: NX_Q15418

Explore proteomics data for RPS6KA1 at MOPED 

Post-translational modifications:

  • UniProtKB: Activated by phosphorylation at Ser-221 by PDPK1. Autophosphorylated on Ser-380, as part of the activation
    process. May be phosphorylated at Thr-359 and Ser-363 by MAPK1/ERK2 and MAPK3/ERK1
  • UniProtKB: N-terminal myristoylation results in an activated kinase in the absence of added growth factors
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15418

  • 4/50 DME Specific Peptides for RPS6KA1 (Q15418) (see all 50)
     VVHRDLK  DKILRQK  CDIWSLG  KLTDFGL 

    RPS6KA1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RPS6KA1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001006666.1  NP_002944.2  

    ENSEMBL proteins: 
     ENSP00000434616   ENSP00000436990   ENSP00000363283   ENSP00000363281   ENSP00000431651  
     ENSP00000433039   ENSP00000432281   ENSP00000355831   ENSP00000363278   ENSP00000435412  
     ENSP00000383967   ENSP00000403548   ENSP00000363277  
    Reactome Protein details: Q15418
    Human Recombinant Protein Products for RPS6KA1: 
    EMD Millipore Purified and/or Recombinant RPS6KA1 Protein
    R&D Systems Recombinant & Natural Proteins for RPS6KA1 (RSK1)
    Enzo Life Sciences proteins for RPS6KA1
    OriGene Purified Protein for RPS6KA1
    OriGene Protein Over-expression Lysate for RPS6KA1
    OriGene MassSpec for RPS6KA1 
    OriGene Custom Protein Services for RPS6KA1
    GenScript Custom Purified and Recombinant Proteins Services for RPS6KA1
    Novus Biologicals RPS6KA1 Proteins
    Novus Biologicals RPS6KA1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA--
    GO:0005819spindle IEA--
    GO:0005829cytosol TAS--

    RPS6KA1 for ontologies           About GeneDecksing



    RPS6KA1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of RPS6KA1
    R&D Systems Antibodies for RPS6KA1 (RSK1)
    Cell Signaling Technology (CST) Antibodies for RPS6KA1  (p90RSK)
    OriGene Antibodies for RPS6KA1
    OriGene Custom Antibody Services for RPS6KA1
    GenScript Custom Superior Antibodies Services for RPS6KA1
    Novus Biologicals RPS6KA1 Antibodies
    Abcam antibodies for RPS6KA1
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for RPS6KA1
    LSBio Antibodies in human, mouse, rat for RPS6KA1 

    Assay Products for RPS6KA1: 
    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for RPS6KA1 (RSK1)         (see all)
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    Cell Signaling Technology (CST) Sandwich ELISA Kits for RPS6KA1 (p90RSK)
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: ribosomal protein S6 kinase, 90kDa, polypeptide 1 
    RSK subfamily
    Other AGC kinases

    5/8 InterPro protein domains (see all 8):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR000961 AGC-kinase_C
     IPR011009 Kinase-like_dom
     IPR017892 Pkinase_C

    Graphical View of Domain Structure for InterPro Entry Q15418

    ProtoNet protein and cluster: Q15418

    1 Blocks protein domain: IPB000961 Protein kinase C-terminal domain

    UniProtKB/Swiss-Prot: KS6A1_HUMAN, Q15418
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 2 protein kinase domains


    RPS6KA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KS6A1_HUMAN, Q15418
    Function: Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and
    mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77,
    regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and
    differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In
    fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent
    transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA),
    phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon
    insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B
    at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent
    mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex. In response
    to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent
    translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798',
    which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which
    regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway.
    Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their
    pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to
    the hepatotoxin carbon tetrachloride (CCl4). Is involved in cell cycle regulation by phosphorylating the CDK
    inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the
    nucleus and inhibition of G1 progression
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Upon extracellular signal or mitogen stimulation, phosphorylated at Thr-573 in the C-terminal
    kinase domain (CTKD) by MAPK1/ERK2 and MAPK3/ERK1. The activated CTKD then autophosphorylates Ser-380, allowing
    binding of PDPK1, which in turn phosphorylates Ser-221 in the N-terminal kinase domain (NTDK) leading to the full
    activation of the protein and subsequent phosphorylation of the substrates by the NTKD

         Genatlas biochemistry entry for RPS6KA1:
    ribosomal protein S6 kinase,polypeptide 1,not involved in vivo in the phosphorylation of RPS6,mediating protein
    synthesis initiation and elongation induced by hormones or growth factors,maybe playing an essentilal regulatory
    role in protein synthesis during cell proliferation

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA10679322
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI--
         
    RPS6KA1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for RPS6KA1:
     Decreased substrate adherent c  Increased cell death HMECs cel  Synthetic lethal with cisplati 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RPS6KA1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RPS6KA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RPS6KA1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RPS6KA1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPS6KA1
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate RPS6KA1 (see all 31):
    hsa-miR-125a-5p hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-302e hsa-miR-342-3p hsa-miR-520a-3p hsa-miR-4314
    SwitchGear 3'UTR luciferase reporter plasmidRPS6KA1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RPS6KA1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS6KA1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RPS6KA1
    Sirion Biotech Customized adenovirus for overexpression of RPS6KA1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RPS6KA1 (see all 13)
    OriGene ORF clones in mouse, rat for RPS6KA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RPS6KA1 (NM_002953)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPS6KA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS6KA1
    Sirion Biotech Customized lentivirus for stable overexpression of RPS6KA1 
                         Customized lentivirus expression plasmids for stable overexpression of RPS6KA1 

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS6KA1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RPS6KA1 About   (see all 55)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Development EGFR signaling pathway
    Development GDNF family signaling0.45
    BDNF Pathway0.39
    GDNF-Family Ligands and Receptor Interactions0.41
    2Translation Insulin regulation of translation
    Translation Insulin regulation of translation0.59
    mTOR signaling pathway0.34
    Regulation of lipid metabolism Insulin signaling:generic cascades0.59
    3Development IGF-RI signaling
    Development IGF-RI signaling0.49
    Development IGF-1 receptor signaling0.48
    4Development Dopamine D2 receptor transactivation of EGFR
    Apoptosis and survival BAD phosphorylation0.41
    BAD Phosphorylation0.41
    5Development HGF signaling pathway
    Neurotrophin signaling pathway0.36
    Apoptosis and survival Anti-apoptotic action of membrane-bound ESR10.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/13 EMD Millipore Pathways for RPS6KA1 (see all 13)
        Translation Insulin regulation of translation
    Development A2A receptor signaling
    Development GDNF family signaling
    Immune response IL-9 signaling pathway
    Transcription CREB pathway

    5/23 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RPS6KA1 (see all 23)
        FLT3 Signaling
    MAPK Signaling
    14-3-3 Induced Apoptosis
    Mitochondrial Apoptosis
    TRKA Signaling

    1 Cell Signaling Technology (CST) Pathway for RPS6KA1
        MAP Kinase Signaling

    5 Tocris Bioscience Pathways for RPS6KA1
        Insulin Pathway
    Apoptosis Pathway
    NF-kappaB Pathway
    MAPK Pathway
    mTOR Pathway

    5/14 GeneGo (Thomson Reuters) Pathways for RPS6KA1 (see all 14)
        Development A2A receptor signaling
    Apoptosis and survival BAD phosphorylation
    Signal transduction PKA signaling
    Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
    Immune response IL-9 signaling pathway

    5/13 BioSystems Pathways for RPS6KA1 (see all 13)
        EGFR1 Signaling Pathway
    Insulin Signaling
    BDNF signaling pathway
    IL-5 Signaling Pathway
    Kit Receptor Signaling Pathway

    5/42        Reactome Pathways for RPS6KA1 (see all 42)
        CREB phosphorylation
    L1CAM interactions
    Toll Like Receptor 2 (TLR2) Cascade
    Toll Like Receptor TLR6:TLR2 Cascade
    Post NMDA receptor activation events


    5/6         Kegg Pathways  (Kegg details for RPS6KA1) (see all 6):
        MAPK signaling pathway
    Oocyte meiosis
    mTOR signaling pathway
    Long-term potentiation
    Neurotrophin signaling pathway


    RPS6KA1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RPS6KA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/91 Interacting proteins for RPS6KA1 (Q154181, 2, 3 ENSP000003632774) via UniProtKB, MINT, STRING, and/or I2D (see all 91)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDAH2O958652, 3MINT-8269417 I2D: score=2 
    ENSG00000206395O958652, 3MINT-8269417 I2D: score=2 
    ENSG00000225635O958652, 3MINT-8269417 I2D: score=2 
    ENSG00000226634O958652, 3MINT-8269417 I2D: score=2 
    ENSG00000227317O958652, 3MINT-8269417 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/30 biological process terms (GO ID links to tree view) (see all 30):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006468protein phosphorylation ----
    GO:0007049cell cycle IEA--

    RPS6KA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RPS6KA1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for RPS6KA1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BRD 7389p90 ribosomal S6 kinase inhibitor[376382-11-5]
    PF 4708671S6K1 inhibitor[1255517-76-0]
    SL 0101-1Selective p90 ribosomal S6 kinase (RSK) inhibitor[77307-50-7]

    3 HMDB Compounds for RPS6KA1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    1 DrugBank Compound for RPS6KA1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Purvalanol A6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine (see all 2)212844-53-6target--10592235

    10/14 Novoseek inferred chemical compound relationships for RPS6KA1 gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rapamycin 67.4 10 12668683 (2), 16819968 (2), 15963500 (1), 14653992 (1) (see all 6)
    threonine 60.1 10 18084084 (2), 11585927 (1), 12618428 (1), 15919995 (1) (see all 9)
    serine 53.8 12 18084084 (2), 11108839 (2), 11585927 (1), 12235136 (1) (see all 10)
    phosphoinositide 46.7 2 17617058 (1), 15910284 (1)
    pd 98,059 44.3 5 11237744 (1), 11278385 (1), 8939914 (1), 19718656 (1)
    phosphatidylinositol 42.9 5 12668683 (2), 11108839 (2), 16819968 (1)
    glycogen 31.7 2 11108839 (1), 17850214 (1)
    ly294002 27.7 2 11237744 (1)
    valproate 25.4 3 18677583 (2), 15269271 (1)
    cyclic amp 25 6 16738324 (2)

    Search CenterWatch for drugs/clinical trials and news about RPS6KA1 / KS6A1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RPS6KA1 gene (2 alternative transcripts): 
    NM_001006665.1  NM_002953.3  

    Unigene Cluster for RPS6KA1:

    Ribosomal protein S6 kinase, 90kDa, polypeptide 1
    Hs.149957  [show with all ESTs]
    Unigene Representative Sequence: BC014966
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000525525 ENST00000526040 ENST00000374168(uc001bmr.1 uc010ofe.1)
    ENST00000524436 ENST00000374166 ENST00000526792 ENST00000529454 ENST00000530003
    ENST00000366866 ENST00000531113(uc010off.1) ENST00000374163(uc001bms.1 uc009vsl.1)
    ENST00000530607 ENST00000531382 ENST00000525582 ENST00000527264 ENST00000474934
    ENST00000488985 ENST00000403732
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    Additional mRNA sequence: 

    AK092955.1 AK225672.1 AK292722.1 AK294818.1 AK299007.1 AK315730.1 BC014966.1 BC039069.1 
    L07597.1 

    13 DOTS entries:

    DT.115771  DT.100815795  DT.100815799  DT.91669729  DT.100724903  DT.121440109  DT.121440103  DT.75158566 
    DT.100025261  DT.92435857  DT.95098737  DT.95176807  DT.95114015 

    24/246 AceView cDNA sequences (see all 246):

    BM826042 BI222410 BX115111 BM707116 BQ063412 BQ440925 BQ007911 AI032766 
    AI720046 BM705147 BP367185 AI248135 BQ933350 BF849344 AL135618 CD742998 
    BM673274 BX354559 BI030550 AA479556 BM549979 CA489540 BE513980 AU124715 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for RPS6KA1 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^
    SP1:              -           -                       -           -                                                                       -                 -   
    SP2:                                                  -                                                                                   -                 -   
    SP3:                                                  -           -                                                                                             
    SP4:                                                                                                                                                            
    SP5:                          -                                                                                                                                 

    ExUns: 23 ^ 24 ^ 25 ^ 26
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for RPS6KA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPS6KA1 expression in normal human tissues (normalized intensities)      RPS6KA1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTTTCTAA
    RPS6KA1 Expression
    About this image


    RPS6KA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/28 selected tissues (see all 28) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
     
     Uterus (Reproductive System)    fully expand to see all 3 entries
             uterus, post-menopause ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex

    See RPS6KA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPS6KA1

    SOURCE GeneReport for Unigene cluster: Hs.149957
        SABiosciences Expression via Pathway-Focused PCR Arrays including RPS6KA1: 
              mTOR Signaling in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RPS6KA1 gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rps6ka11 , 5 ribosomal protein S6 kinase polypeptide 11, 5 91.02(n)1
    98.5(a)1
      4 (66.37 cM)5
    201111  NM_009097.41  NP_033123.21 
     1338472905 
    chicken
    (Gallus gallus)
    Aves RPS6KA11 ribosomal protein S6 kinase, 90kDa, polypeptide 1 80.79(n)
    92.23(a)
      386579  NM_001109771.2  NP_001103241.1 
    lizard
    (Anolis carolinensis)
    Reptilia RPS6KA16
    --
    Uncharacterized protein
    88(a)
    71(a)
    1 ↔ 1
    possible ortholog
    GL343488.1(23-16731)
    AAWZ02037155(11978-18689)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.8562 X.laevis ribosomal protein S6 kinase II (S6KII) mRNA, more 76.32(n)    M20187.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rps6ka3a1 ribosomal protein S6 kinase, polypeptide 3a 70.55(n)
    77.95(a)
      338219  NM_212786.1  NP_997951.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta S6kII3 protein amino acid phosphorylation
    protein serine/threonine more
    57(a)
    (best of 2)
      20B1   --
    worm
    (Caenorhabditis elegans)
    Secernentea T01H8.1b3
    rskn-11
    Protein kinase C terminal domain3
    Protein RSKN-11
    63(a)
    (best of 3)3
    59.53(n)1
    62.94(a)1
      I(8582453-8585937)3
    1726471  NM_001026431.11  NP_001021602.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KIN82(YCR091W)4 Putative serine/threonine protein kinase implicated more   --   3(274404-276566) 850453  NP_010015.2 


    ENSEMBL Gene Tree for RPS6KA1 (if available)
    TreeFam Gene Tree for RPS6KA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPS6KA1 gene
    RPS6KA62  AKT12  RPS6KB12  SGK32  C8orf44-SGK32  SGK22  RPS6KA52  AKT32  
    RPS6KA42  SGK12  RPS6KB22  RPS6KA22  RPS6KA32  AKT22  
    18/139 SIMAP similar genes for RPS6KA1 using alignment to 10 protein entries:     KS6A1_HUMAN (see all proteins) (see all similar genes):
    RPS6KA2    RPS6KA3    RPS6KA6    KIN27    RPS6KC1    DCLK3
    MAST4    PRKACB    CDC42BPA    PRKACA    DKFZp564L2416    PRKY
    PRKACG    RPS6KA5    RPS6KB1    CSNK2A3    AKT3    SGK2

    RPS6KA1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/934 SNPs in RPS6KA1 are shown (see all 934)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1510271741,2
    --26854270(+) TGAGCA/CCAGAA 1 -- us2k10--------
    rs1144560221,2
    C,F--26854317(+) ACTGCA/TGCCTA 1 -- us2k11Minor allele frequency- T:0.06NA 120
    rs1897471191,2
    --26854334(+) AGAGCA/GAGACT 1 -- us2k10--------
    rs778618351,2
    C--26854366(+) AAAATA/CTATAG 1 -- us2k12Minor allele frequency- C:0.10WA 120
    rs1916612331,2
    --26854412(+) ATATAC/TCTGAA 1 -- us2k10--------
    rs1410014241,2
    --26854503(+) GGTAGC/TAGAGC 1 -- us2k10--------
    rs1502068771,2
    --26854612(+) GAGCAC/TGTGGA 1 -- us2k10--------
    rs1844427011,2
    --26854664(+) AGATGA/GAGTCT 1 -- us2k10--------
    rs23160021,2
    C,F,A,H--26854674(-) tgggcA/Gacaga 1 -- us2k16Minor allele frequency- G:0.37NA WA 16
    rs1888867551,2
    --26854844(+) TGTTAA/GCCAGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RPS6KA1 (26856249 - 26901521 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RPS6KA1:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv202n71CNV Loss21882294
    nsv526179CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601684    OMIM disorders: --

    20/21 diseases for RPS6KA1 (see all 21):    About MalaCards
    coffin-lowry syndrome    tuberous sclerosis complex    tuberous sclerosis    prostate cancer
    sporadic breast cancer    gout    prostatitis    kaposi's sarcoma
    amyotrophic lateral sclerosis    lateral sclerosis    astrocytoma    breast cancer
    sarcoma    melanoma    alcoholism    thyroiditis
    lung cancer    gastric cancer    hepatitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for RPS6KA1:
    Coffin-Lowry syndrome

    RPS6KA1 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for RPS6KA1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tuberous sclerosis 31.6 1 16738324 (1)
    cancer 0.646 6 15705904 (2), 19470470 (1), 17512736 (1)
    breast cancer 0 4 15705904 (2), 17512736 (1)
    tumors 0 3 19258500 (1), 15342917 (1)
    melanoma 0 2 14678993 (2)

    Genetic Association Database (GAD): RPS6KA1
    Human Genome Epidemiology (HuGE) Navigator: RPS6KA1 (8 documents)

    Export disorders for RPS6KA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPS6KA1 gene, integrated from 9 sources (see all 257):
    (articles sorted by number of sources associating them with RPS6KA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human rsk isoforms: cloning and characterization of tissue-specific expression. (PubMed id 8141249)1, 2, 3, 9 Moller D.E.... Jakubowski M. (1994)
    2. Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity. (PubMed id 12832467)1, 2, 9 Roux P.P.... Blenis J. (2003)
    3. Crystal structures of the N-terminal kinase domain of human RSK1 bound to three different ligands: Implications for the design of RSK1 specific inhibitors. (PubMed id 17965187)1, 2, 9 Ikuta M....Munshi S.K. (2007)
    4. Regulation of the ETS transcription factor ER81 by the 90-kDa ribosomal S6 kinase 1 and protein kinase A. (PubMed id 12213813)1, 2, 9 Wu J. and Janknecht R. (2002)
    5. Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation. (PubMed id 18722121)1, 2, 9 Carriere A....Roux P.P. (2008)
    6. Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. (PubMed id 15342917)1, 2, 9 Roux P.P....Blenis J. (2004)
    7. Genetic variation in RPS6KA1, RPS6KA2, RPS6KB1, RPS6K B2, and PDK1 and risk of colon or rectal cancer. (PubMed id 21035469)1, 4 Slattery M.L....Wolff R.K. (2010)
    8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    9. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1, 4 Vega A....Carracedo A. (2009)
    10. The RSK family of kinases: emerging roles in cellular signalling. (PubMed id 18813292)1, 2 Anjum R. and Blenis J. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6195 HGNC: 10430 AceView: RPS6KA1 Ensembl:ENSG00000117676 euGenes: HUgn6195
    ECgene: RPS6KA1 Kegg: 6195 H-InvDB: RPS6KA1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPS6KA1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RPS6KA1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RPS6KA1 gene:
    Search GeneIP for patents involving RPS6KA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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     RPS6KA1 proteins
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     Antibodies for RPS6KA1
     See all of Abcam's Antibodies, Kits and Proteins for RPS6KA1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for RPS6KA1
     Gene Synthesis
     Protein Engineering
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS6KA1
     SwitchGear 3'UTR luciferase reporter plasmids for RPS6KA1
     SwitchGear Promoter luciferase reporter plasmids for RPS6KA1
     ThermoFisher Antibody for RPS6KA1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS6KA1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for RPS6KA1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RPS6KA1
    Customized:
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     lentivirus expression plasmids for stable overexpression of RPS6KA1
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     LSBio Antibodies in human, mouse, rat for RPS6KA1
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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