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Aliases for RPS6KA1 Gene

Aliases for RPS6KA1 Gene

  • Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 2 3
  • RSK1 3 4 6
  • MAP Kinase-Activated Protein Kinase 1a 3 4
  • 90 KDa Ribosomal Protein S6 Kinase 1 3 4
  • MAPK-Activated Protein Kinase 1a 3 4
  • Ribosomal S6 Kinase 1 3 4
  • MAPKAP Kinase 1a 3 4
  • S6K-Alpha-1 3 4
  • EC 2.7.11.1 4 63
  • MAPKAPK-1a 3 4
  • P90-RSK 1 3 4
  • MAPKAPK1A 3 4
  • P90RSK1 3 4
  • P90S6K 3 4
  • RSK-1 3 4
  • DJ590P13.1 (Ribosomal Protein S6 Kinase, 90kD, Polypeptide 1) 3
  • Ribosomal Protein S6 Kinase, 90kD, Polypeptide 1 2
  • Ribosomal Protein S6 Kinase Alpha 1 3
  • Ribosomal Protein S6 Kinase Alpha-1 3
  • S6K-Alpha 1 3
  • EC 2.7.11 63
  • P90Rsk 3
  • HU-1 3
  • RSK 3

External Ids for RPS6KA1 Gene

Previous GeneCards Identifiers for RPS6KA1 Gene

  • GC01P028654
  • GC01P025888
  • GC01P026089
  • GC01P026460
  • GC01P026728
  • GC01P026856
  • GC01P025110

Summaries for RPS6KA1 Gene

Entrez Gene Summary for RPS6KA1 Gene

  • This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS6KA1 Gene

RPS6KA1 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1) is a Protein Coding gene. Diseases associated with RPS6KA1 include coffin-lowry syndrome and tuberous sclerosis. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include protein serine/threonine kinase activity and cysteine-type endopeptidase inhibitor activity involved in apoptotic process. An important paralog of this gene is MKNK2.

UniProtKB/Swiss-Prot for RPS6KA1 Gene

  • Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at Ser-9 and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex. In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at Ser-1798, which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression.

Tocris Summary for RPS6KA1 Gene

  • p90 ribosomal S6 kinases (RSKs) are a family of protein serine/threonine kinases that regulate diverse cellular processes such as cell growth, motility, survival and proliferation. There are four isoforms of this enzyme; RSK1-4, which are directly activated by ERK1/2 in response to growth factors, many polypeptide hormones, neurotransmitters and chemokines. p90 RSKs phosphorylate numerous cytosolic and nuclear targets and act as downstream effectors of the ERK/MAPK signaling cascade. They are expressed ubiquitously in human tissues and exist in multiple subcellular compartments. Abberant activation of p90 RSKs has been linked to many human diseases, including breast and prostate cancers.

Gene Wiki entry for RPS6KA1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS6KA1 Gene

Genomics for RPS6KA1 Gene

Regulatory Elements for RPS6KA1 Gene

Genomic Location for RPS6KA1 Gene

Start:
26,529,758 bp from pter
End:
26,575,030 bp from pter
Size:
45,273 bases
Orientation:
Plus strand

Genomic View for RPS6KA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPS6KA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS6KA1 Gene

Proteins for RPS6KA1 Gene

  • Protein details for RPS6KA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15418-KS6A1_HUMAN
    Recommended name:
    Ribosomal protein S6 kinase alpha-1
    Protein Accession:
    Q15418
    Secondary Accessions:
    • A6NGG4
    • A8K9K7
    • B2RDY8
    • B7Z5J0
    • E9PRI4
    • Q5SVM5
    • Q5SVM8
    • Q5SVM9
    • Q96C05
    • Q9BQK2

    Protein attributes for RPS6KA1 Gene

    Size:
    735 amino acids
    Molecular mass:
    82723 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells. Transiently dissociates following mitogenic stimulation. Interacts with ETV1/ER81 and FGFR1.

    Three dimensional structures from OCA and Proteopedia for RPS6KA1 Gene

    Alternative splice isoforms for RPS6KA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPS6KA1 Gene

Proteomics data for RPS6KA1 Gene at MOPED

Post-translational modifications for RPS6KA1 Gene

  • Activated by phosphorylation at Ser-221 by PDPK1. Autophosphorylated on Ser-380, as part of the activation process. May be phosphorylated at Thr-359 and Ser-363 by MAPK1/ERK2 and MAPK3/ERK1.
  • N-terminal myristoylation results in an activated kinase in the absence of added growth factors
  • Ubiquitination at Lys66, Lys75, Lys278, Lys316, Lys500, Lys562, Lys587, and Lys654
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RPS6KA1 (p90RSK)

Domains for RPS6KA1 Gene

Graphical View of Domain Structure for InterPro Entry

Q15418

UniProtKB/Swiss-Prot:

KS6A1_HUMAN :
  • Q15418
Domain:
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 2 protein kinase domains.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
genes like me logo Genes that share domains with RPS6KA1: view

Function for RPS6KA1 Gene

Molecular function for RPS6KA1 Gene

GENATLAS Biochemistry:
ribosomal protein S6 kinase,polypeptide 1,not involved in vivo in the phosphorylation of RPS6,mediating protein synthesis initiation and elongation induced by hormones or growth factors,maybe playing an essentilal regulatory role in protein synthesis during cell proliferation
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation:
Upon extracellular signal or mitogen stimulation, phosphorylated at Thr-573 in the C-terminal kinase domain (CTKD) by MAPK1/ERK2 and MAPK3/ERK1. The activated CTKD then autophosphorylates Ser-380, allowing binding of PDPK1, which in turn phosphorylates Ser-221 in the N-terminal kinase domain (NTDK) leading to the full activation of the protein and subsequent phosphorylation of the substrates by the NTKD.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at Ser-9 and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex. In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at Ser-1798, which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression.

Enzyme Numbers (IUBMB) for RPS6KA1 Gene

Gene Ontology (GO) - Molecular Function for RPS6KA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 10679322
GO:0004711 ribosomal protein S6 kinase activity IBA --
GO:0004712 protein serine/threonine/tyrosine kinase activity IDA 22797923
genes like me logo Genes that share ontologies with RPS6KA1: view

Phenotypes for RPS6KA1 Gene

genes like me logo Genes that share phenotypes with RPS6KA1: view

Animal Model Products

CRISPR Products

miRNA for RPS6KA1 Gene

miRTarBase miRNAs that target RPS6KA1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPS6KA1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for RPS6KA1 Gene

Localization for RPS6KA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS6KA1 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS6KA1 Gene COMPARTMENTS Subcellular localization image for RPS6KA1 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 2
extracellular 1

Gene Ontology (GO) - Cellular Components for RPS6KA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005819 spindle IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RPS6KA1: view

Pathways for RPS6KA1 Gene

genes like me logo Genes that share pathways with RPS6KA1: view

PCR Array Products

Gene Ontology (GO) - Biological Process for RPS6KA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0006468 protein phosphorylation IBA --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with RPS6KA1: view

Compounds for RPS6KA1 Gene

(3) Tocris Compounds for RPS6KA1 Gene

Compound Action Cas Number
BRD 7389 p90 ribosomal S6 kinase inhibitor [376382-11-5]
PF 4708671 S6K1 inhibitor [1255517-76-0]
SL 0101-1 Selective p90 ribosomal S6 kinase (RSK) inhibitor [77307-50-7]

(2) ApexBio Compounds for RPS6KA1 Gene

Compound Action Cas Number
BI-D1870 "P90 RSK inhibitor,ATP-competitive and cell-permeable" [501437-28-1]
PF-4708671 "P70 S6K1 isoform inhibitor,cell-permeable" [1255517-76-0]

(3) HMDB Compounds for RPS6KA1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4

(1) Drugbank Compounds for RPS6KA1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Purvalanol A
  • 6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine
212844-53-6 target

(14) Novoseek inferred chemical compound relationships for RPS6KA1 Gene

Compound -log(P) Hits PubMed IDs
rapamycin 67.4 8
threonine 60.1 10
serine 53.8 12
phosphoinositide 46.7 2
pd 98,059 44.3 4
genes like me logo Genes that share compounds with RPS6KA1: view

Transcripts for RPS6KA1 Gene

Unigene Clusters for RPS6KA1 Gene

Ribosomal protein S6 kinase, 90kDa, polypeptide 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPS6KA1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS6KA1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^
SP1: - - - - - -
SP2: - - -
SP3: - -
SP4:
SP5: -
SP6:
SP7:

ExUns: 23 ^ 24 ^ 25 ^ 26
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for RPS6KA1 Gene

GeneLoc Exon Structure for
RPS6KA1
ECgene alternative splicing isoforms for
RPS6KA1

Expression for RPS6KA1 Gene

mRNA expression in normal human tissues for RPS6KA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RPS6KA1 Gene

This gene is overexpressed in Whole Blood (21.5).

Protein differential expression in normal tissues for RPS6KA1 Gene

This gene is overexpressed in Lymph node (11.8), Stomach (7.0), Peripheral blood mononuclear cells (7.0), and Salivary gland (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS6KA1 Gene

SOURCE GeneReport for Unigene cluster for RPS6KA1 Gene Hs.149957

genes like me logo Genes that share expressions with RPS6KA1: view

Expression partners for RPS6KA1 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RPS6KA1 Gene

Orthologs for RPS6KA1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RPS6KA1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPS6KA1 35
  • 92.38 (n)
  • 99.05 (a)
RPS6KA1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPS6KA1 35
  • 91.09 (n)
  • 96.56 (a)
RPS6KA1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rps6ka1 35
  • 91.02 (n)
  • 98.5 (a)
Rps6ka1 16
Rps6ka1 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPS6KA1 35
  • 99.82 (n)
  • 100 (a)
RPS6KA1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rps6ka1 35
  • 90.16 (n)
  • 97.55 (a)
oppossum
(Monodelphis domestica)
Mammalia RPS6KA1 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPS6KA1 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPS6KA1 35
  • 80.84 (n)
  • 92.23 (a)
RPS6KA 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 69 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rps6ka1 35
  • 73.49 (n)
  • 85.95 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.856 35
zebrafish
(Danio rerio)
Actinopterygii rps6ka3a 35
  • 70.55 (n)
  • 77.95 (a)
rps6ka1 36
  • 80 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Pk17E 37
  • 42 (a)
S6kII 37
  • 57 (a)
S6kII 36
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F28C10.3 37
  • 36 (a)
R04A9.5 37
  • 45 (a)
T01H8.1b 37
  • 63 (a)
rskn-1 35
  • 58.97 (n)
  • 62.73 (a)
rskn-1 36
  • 55 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIN82 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 69 (a)
OneToMany
Species with no ortholog for RPS6KA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS6KA1 Gene

ENSEMBL:
Gene Tree for RPS6KA1 (if available)
TreeFam:
Gene Tree for RPS6KA1 (if available)

Paralogs for RPS6KA1 Gene

genes like me logo Genes that share paralogs with RPS6KA1: view

Variants for RPS6KA1 Gene

Sequence variations from dbSNP and Humsavar for RPS6KA1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs7726 -- 26,574,828(+) CCCCT(A/G)CGGTC utr-variant-3-prime
rs11113 -- 26,574,599(+) CCCCA(C/T)GATTG utr-variant-3-prime
rs14071 -- 26,574,610(-) CTACA(A/G)GTGGC utr-variant-3-prime
rs188158 -- 26,571,651(-) TCCAA(C/T)TCCCC intron-variant
rs190737 -- 26,572,953(-) CCTCA(G/T)GTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPS6KA1 Gene

Variant ID Type Subtype PubMed ID
dgv202n71 CNV Loss 21882294
nsv526179 CNV Gain 19592680

Relevant External Links for RPS6KA1 Gene

HapMap Linkage Disequilibrium report
RPS6KA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS6KA1 Gene

Disorders for RPS6KA1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for RPS6KA1 Gene in MalaCards »

(2) Diseases for RPS6KA1 Gene including...

(1) University of Copenhagen DISEASES for RPS6KA1 Gene

(5) Novoseek inferred disease relationships for RPS6KA1 Gene

Disease -log(P) Hits PubMed IDs
tuberous sclerosis 31.6 1
cancer 0.646 4
breast cancer 0 3
tumors 0 2
melanoma 0 2

Relevant External Links for RPS6KA1

Genetic Association Database (GAD)
RPS6KA1
Human Genome Epidemiology (HuGE) Navigator
RPS6KA1
genes like me logo Genes that share disorders with RPS6KA1: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for RPS6KA1 Gene

Publications for RPS6KA1 Gene

  1. Human rsk isoforms: cloning and characterization of tissue-specific expression. (PMID: 8141249) Moller D.E. … Jakubowski M. (Am. J. Physiol. 1994) 2 3 4 23
  2. Regulation of the ETS transcription factor ER81 by the 90-kDa ribosomal S6 kinase 1 and protein kinase A. (PMID: 12213813) Wu J. … Janknecht R. (J. Biol. Chem. 2002) 3 4 23
  3. Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity. (PMID: 12832467) Roux P.P. … Blenis J. (Mol. Cell. Biol. 2003) 3 4 23
  4. Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. (PMID: 15342917) Roux P.P. … Blenis J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 23
  5. Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK- mediated raptor phosphorylation. (PMID: 18722121) Carriere A. … Roux P.P. (Curr. Biol. 2008) 3 4 23

Products for RPS6KA1 Gene

Sources for RPS6KA1 Gene

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