Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RPS6KA1 Gene

Aliases for RPS6KA1 Gene

  • Ribosomal Protein S6 Kinase A1 2 3 5
  • MAP Kinase-Activated Protein Kinase 1a 3 4
  • 90 KDa Ribosomal Protein S6 Kinase 1 3 4
  • MAPK-Activated Protein Kinase 1a 3 4
  • Ribosomal S6 Kinase 1 3 4
  • MAPKAP Kinase 1a 3 4
  • EC 2.7.11.1 4 61
  • MAPKAPK-1a 3 4
  • P90-RSK 1 3 4
  • MAPKAPK1A 3 4
  • P90RSK1 3 4
  • P90S6K 3 4
  • RSK-1 3 4
  • RSK1 3 4
  • DJ590P13.1 (Ribosomal Protein S6 Kinase, 90kD, Polypeptide 1) 3
  • Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 3
  • Ribosomal Protein S6 Kinase, 90kD, Polypeptide 1 2
  • Ribosomal Protein S6 Kinase Alpha-1 3
  • S6K-Alpha 1 3
  • S6K-Alpha-1 4
  • EC 2.7.11 61
  • P90Rsk 3
  • HU-1 3
  • RSK 3

External Ids for RPS6KA1 Gene

Previous GeneCards Identifiers for RPS6KA1 Gene

  • GC01P028654
  • GC01P025888
  • GC01P026089
  • GC01P026460
  • GC01P026728
  • GC01P026856
  • GC01P025110

Summaries for RPS6KA1 Gene

Entrez Gene Summary for RPS6KA1 Gene

  • This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS6KA1 Gene

RPS6KA1 (Ribosomal Protein S6 Kinase A1) is a Protein Coding gene. Diseases associated with RPS6KA1 include Coffin-Lowry Syndrome and Adrenal Cortical Adenocarcinoma. Among its related pathways are Activated TLR4 signalling and IL-2 Pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is RPS6KA3.

UniProtKB/Swiss-Prot for RPS6KA1 Gene

  • Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at Ser-9 and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex. In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at Ser-1798, which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (By similarity). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression. Phosphorylates EPHA2 at Ser-897, the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630).

Tocris Summary for RPS6KA1 Gene

  • Ribosomal S6 protein kinases (RSKs) are a family of protein serine/threonine kinases that regulate diverse cellular processes such as cellular growth, motility, survival and proliferation. The RSK family can be divided into two subfamilies, namely p90 RSK and p70 S6K.

Gene Wiki entry for RPS6KA1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS6KA1 Gene

Genomics for RPS6KA1 Gene

Regulatory Elements for RPS6KA1 Gene

Enhancers for RPS6KA1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F026721 2.8 VISTA Ensembl ENCODE 10.1 +194.9 194943 7.0 PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 PIGV ZDHHC18 ARID1A SFN ENSG00000226698 RPS6KA1 GPATCH3 NUDC NPM1P39 HMGN2
GH01F026691 2.7 FANTOM5 ENCODE 10.2 +167.3 167303 12.9 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 HMGN2 ACTG1P20 PIGV NPM1P39 LOC101928728 LOC101928324 ZDHHC18 LOC105376890 ENSG00000207302 GPATCH3
GH01F026782 1.7 FANTOM5 Ensembl ENCODE 15.6 +257.4 257389 9.2 CREB3L1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 MEF2D HMGN2 ZDHHC18 NPM1P39 RPS6KA1 PIGV LOC101928728 ENSG00000231344 RPL17P9 LOC101928324 ACTG1P20
GH01F026499 1.8 FANTOM5 Ensembl ENCODE 13.6 -28.7 -28658 3.0 HDGF ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF766 HMGN2 LOC101928324 ACTG1P20 NPM1P39 RPL17P9 LIN28A ENSG00000207302 LOC105376890 DHDDS RPL39P7
GH01F026618 1.9 FANTOM5 Ensembl ENCODE 12.7 +90.4 90444 4.4 CREB3L1 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 SP3 TBX21 HMGN2 ACTG1P20 NPM1P39 RPL17P9 AHDC1 GPATCH3 LOC101928324 WASF2 LOC105376890 ENSG00000207302
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPS6KA1 on UCSC Golden Path with GeneCards custom track

Promoters for RPS6KA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000164246 242 1601 ZNF76 SIN3A ZBTB40 RFX5 ZNF335 CREM SMAD5 SMARCB1 NR2F2 SMARCA4
ENSR00001743004 1542 201 ARID4B ZNF48 ZNF2 GLIS2 KLF7 ZNF548 FOS DEK SP3 YY2

Genomic Location for RPS6KA1 Gene

Chromosome:
1
Start:
26,529,758 bp from pter
End:
26,575,030 bp from pter
Size:
45,273 bases
Orientation:
Plus strand

Genomic View for RPS6KA1 Gene

Genes around RPS6KA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS6KA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS6KA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS6KA1 Gene

Proteins for RPS6KA1 Gene

  • Protein details for RPS6KA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15418-KS6A1_HUMAN
    Recommended name:
    Ribosomal protein S6 kinase alpha-1
    Protein Accession:
    Q15418
    Secondary Accessions:
    • A6NGG4
    • A8K9K7
    • B2RDY8
    • B7Z5J0
    • E9PRI4
    • Q5SVM5
    • Q5SVM8
    • Q5SVM9
    • Q96C05
    • Q9BQK2

    Protein attributes for RPS6KA1 Gene

    Size:
    735 amino acids
    Molecular mass:
    82723 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells. Transiently dissociates following mitogenic stimulation. Interacts with ETV1/ER81 and FGFR1.

    Three dimensional structures from OCA and Proteopedia for RPS6KA1 Gene

    Alternative splice isoforms for RPS6KA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPS6KA1 Gene

Selected DME Specific Peptides for RPS6KA1 Gene

Q15418:
  • DVKFYLAEL
  • ELMRGGELLD
  • GIIYRDLK
  • DKILRQK
  • FTRLSKEV
  • LVKGAMAATYSALN
  • VSKMLHVDPHQRLTA
  • EAQSLLRALFKRNPANRLGSGPDGAEEIKRH
  • LDHLHSLGIIYRDLKPENILLDEEGHIK
  • PFVVKLH
  • YSFCGTVEYMAPEV
  • LYAMKVL
  • LHYAFQT
  • TNMEYAVKVIDK
  • QGVVHRDLKPSNILY
  • HKATNME
  • PLHSVVQQLHGKN
  • RLTAKQVL
  • GHIKLTDFGLSK
  • ILKAKLGMPQFLS
  • HRDLKPSNIL
  • FYSTIDWNKLYRREIKPPFKPAV
  • IKLTDFG
  • AVKVIDK
  • IGVGSYS
  • LKVRDRVRTKMERDIL
  • GVLMFEMLTG
  • EYAVKVID
  • VVHRDLK
  • LTDFGLSK
  • CDIWSLG
  • KLTDFGL
  • KRDPSEEIEIL
  • TPFANGP
  • IDKSKRDP
  • FRGFSFV
  • EYMAPEVV
  • LGIIYRD
  • RDLKPEN
  • GHIKLTD
  • RYGQHPNII
  • GKVFLVRK
  • FELLKVLG
  • TPCYTANFVAPEVL
  • QVLQHPW
  • LPFQGKDR
  • SSILAQRRV
  • VHRDLKP
  • ILRQKFFSEREA
  • KPENILLD

Post-translational modifications for RPS6KA1 Gene

  • Activated by phosphorylation at Ser-221 by PDPK1. Autophosphorylated on Ser-380, as part of the activation process. May be phosphorylated at Thr-359 and Ser-363 by MAPK1/ERK2 and MAPK3/ERK1.
  • N-terminal myristoylation results in an activated kinase in the absence of added growth factors.
  • Ubiquitination at Lys 66, Lys 278, and Lys 316
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RPS6KA1 (p90RSK)
  • Cloud-Clone Corp. Antibodies for RPS6KA1

Domains & Families for RPS6KA1 Gene

Graphical View of Domain Structure for InterPro Entry

Q15418

UniProtKB/Swiss-Prot:

KS6A1_HUMAN :
  • Contains 1 AGC-kinase C-terminal domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
Domain:
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 2 protein kinase domains.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
genes like me logo Genes that share domains with RPS6KA1: view

Function for RPS6KA1 Gene

Molecular function for RPS6KA1 Gene

GENATLAS Biochemistry:
ribosomal protein S6 kinase,polypeptide 1,not involved in vivo in the phosphorylation of RPS6,mediating protein synthesis initiation and elongation induced by hormones or growth factors,maybe playing an essentilal regulatory role in protein synthesis during cell proliferation
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Upon extracellular signal or mitogen stimulation, phosphorylated at Thr-573 in the C-terminal kinase domain (CTKD) by MAPK1/ERK2 and MAPK3/ERK1. The activated CTKD then autophosphorylates Ser-380, allowing binding of PDPK1, which in turn phosphorylates Ser-221 in the N-terminal kinase domain (NTDK) leading to the full activation of the protein and subsequent phosphorylation of the substrates by the NTKD.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at Ser-9 and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex. In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at Ser-1798, which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (By similarity). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression. Phosphorylates EPHA2 at Ser-897, the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630).

Enzyme Numbers (IUBMB) for RPS6KA1 Gene

Gene Ontology (GO) - Molecular Function for RPS6KA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,TAS --
GO:0004712 protein serine/threonine/tyrosine kinase activity IDA 22797923
GO:0005515 protein binding IPI 21423205
genes like me logo Genes that share ontologies with RPS6KA1: view
genes like me logo Genes that share phenotypes with RPS6KA1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS6KA1 Gene

Localization for RPS6KA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS6KA1 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS6KA1 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 2
cytoskeleton 2
plasma membrane 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPS6KA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RPS6KA1: view

Pathways & Interactions for RPS6KA1 Gene

SuperPathways for RPS6KA1 Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
2 Post NMDA receptor activation events
3 Nuclear Events (kinase and transcription factor activation)
4 Translation Insulin regulation of translation
5 GDNF-Family Ligands and Receptor Interactions
genes like me logo Genes that share pathways with RPS6KA1: view

SIGNOR curated interactions for RPS6KA1 Gene

Gene Ontology (GO) - Biological Process for RPS6KA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0006915 apoptotic process IEA --
GO:0007049 cell cycle IEA --
GO:0007165 signal transduction TAS 8141249
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with RPS6KA1: view

Drugs & Compounds for RPS6KA1 Gene

(15) Drugs for RPS6KA1 Gene - From: DrugBank, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Purvalanol A Experimental Pharma Target 0
BRD 7389 Pharma P90 RSK inhibitor, Ribosomal S6 kinase inhibitor 0
PF-4708671 Pharma P70 S6K1 isoform inhibitor,cell-permeable, S6K1 inhibitor 0
SL 0101-1 Pharma Selective ribosomal S6 kinase (RSK) inhibitor 0

(7) Additional Compounds for RPS6KA1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(3) Tocris Compounds for RPS6KA1 Gene

Compound Action Cas Number
BRD 7389 Ribosomal S6 kinase inhibitor 376382-11-5
PF 4708671 S6K1 inhibitor 1255517-76-0
SL 0101-1 Selective ribosomal S6 kinase (RSK) inhibitor 77307-50-7

(4) ApexBio Compounds for RPS6KA1 Gene

Compound Action Cas Number
BI-D1870 P90 RSK inhibitor,ATP-competitive and cell-permeable 501437-28-1
BRD 7389 P90 RSK inhibitor 376382-11-5
PF-4708671 P70 S6K1 isoform inhibitor,cell-permeable 1255517-76-0
SL 0101-1 77307-50-7
genes like me logo Genes that share compounds with RPS6KA1: view

Transcripts for RPS6KA1 Gene

Unigene Clusters for RPS6KA1 Gene

Ribosomal protein S6 kinase, 90kDa, polypeptide 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS6KA1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^
SP1: - - - - - -
SP2: - - -
SP3: - -
SP4:
SP5: -
SP6:
SP7:

ExUns: 23 ^ 24 ^ 25 ^ 26
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for RPS6KA1 Gene

GeneLoc Exon Structure for
RPS6KA1
ECgene alternative splicing isoforms for
RPS6KA1

Expression for RPS6KA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPS6KA1 Gene

mRNA differential expression in normal tissues according to GTEx for RPS6KA1 Gene

This gene is overexpressed in Whole Blood (x21.5).

Protein differential expression in normal tissues from HIPED for RPS6KA1 Gene

This gene is overexpressed in Lymph node (11.8), Stomach (7.0), Peripheral blood mononuclear cells (7.0), and Salivary gland (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPS6KA1 Gene



Protein tissue co-expression partners for RPS6KA1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RPS6KA1 Gene:

RPS6KA1

SOURCE GeneReport for Unigene cluster for RPS6KA1 Gene:

Hs.149957
genes like me logo Genes that share expression patterns with RPS6KA1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for RPS6KA1 Gene

Orthologs for RPS6KA1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RPS6KA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPS6KA1 35 34
  • 99.82 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RPS6KA1 34 35
  • 92.38 (n)
dog
(Canis familiaris)
Mammalia RPS6KA1 35 34
  • 91.09 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rps6ka1 16 35 34
  • 91.02 (n)
rat
(Rattus norvegicus)
Mammalia Rps6ka1 34
  • 90.16 (n)
oppossum
(Monodelphis domestica)
Mammalia RPS6KA1 35
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPS6KA1 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPS6KA 35
  • 88 (a)
OneToOne
RPS6KA1 34
  • 80.84 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 88 (a)
OneToMany
-- 35
  • 69 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rps6ka1 34
  • 73.49 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.856 34
zebrafish
(Danio rerio)
Actinopterygii rps6ka1 35
  • 80 (a)
OneToOne
rps6ka3a 34
  • 70.55 (n)
fruit fly
(Drosophila melanogaster)
Insecta S6kII 36 35
  • 57 (a)
Pk17E 36
  • 42 (a)
worm
(Caenorhabditis elegans)
Secernentea T01H8.1b 36
  • 63 (a)
rskn-1 34 35
  • 58.97 (n)
R04A9.5 36
  • 45 (a)
F28C10.3 36
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIN82 37
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 69 (a)
OneToMany
Species where no ortholog for RPS6KA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS6KA1 Gene

ENSEMBL:
Gene Tree for RPS6KA1 (if available)
TreeFam:
Gene Tree for RPS6KA1 (if available)

Paralogs for RPS6KA1 Gene

genes like me logo Genes that share paralogs with RPS6KA1: view

Variants for RPS6KA1 Gene

Sequence variations from dbSNP and Humsavar for RPS6KA1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1002487 -- 26,539,480(-) AGGTT(A/G)CAAGG intron-variant
rs1002488 -- 26,539,431(-) CCTGA(C/T)TCTCT intron-variant
rs10458602 -- 26,560,468(+) TTTCC(C/G)ACTCC intron-variant
rs10493038 -- 26,539,197(-) CTCGT(C/T)ATGCT intron-variant
rs10493039 -- 26,538,308(-) GAACA(C/T)CGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPS6KA1 Gene

Variant ID Type Subtype PubMed ID
nsv545908 CNV loss 21841781
nsv526179 CNV gain 19592680
esv3577795 CNV loss 25503493
esv3409657 CNV duplication 20981092

Variation tolerance for RPS6KA1 Gene

Residual Variation Intolerance Score: 14.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.35; 81.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS6KA1 Gene

Human Gene Mutation Database (HGMD)
RPS6KA1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPS6KA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS6KA1 Gene

Disorders for RPS6KA1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for RPS6KA1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
coffin-lowry syndrome
  • mental retardation with osteocartilaginous abnormalities
adrenal cortical adenocarcinoma
  • adrenocortical carcinoma
hemorrhoid
  • hemorrhoidal disease
tuberous sclerosis-1
  • tuberous sclerosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RPS6KA1

Genetic Association Database (GAD)
RPS6KA1
Human Genome Epidemiology (HuGE) Navigator
RPS6KA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPS6KA1
genes like me logo Genes that share disorders with RPS6KA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS6KA1 Gene

Publications for RPS6KA1 Gene

  1. Human rsk isoforms: cloning and characterization of tissue-specific expression. (PMID: 8141249) Moller D.E. … Jakubowski M. (Am. J. Physiol. 1994) 2 3 4 22 64
  2. Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK- mediated raptor phosphorylation. (PMID: 18722121) Carriere A. … Roux P.P. (Curr. Biol. 2008) 3 4 22 64
  3. Crystal structures of the N-terminal kinase domain of human RSK1 bound to three different ligands: Implications for the design of RSK1 specific inhibitors. (PMID: 17965187) Ikuta M. … Munshi S.K. (Protein Sci. 2007) 3 4 22 64
  4. Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. (PMID: 15342917) Roux P.P. … Blenis J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 22 64
  5. Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity. (PMID: 12832467) Roux P.P. … Blenis J. (Mol. Cell. Biol. 2003) 3 4 22 64

Products for RPS6KA1 Gene