Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RPS6KA1 Gene

protein-coding   GIFtS: 74
GCID: GC01P026856

Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1

(Previous names: ribosomal protein S6 kinase, 90kD, polypeptide 1)
  See RPS6KA1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 11 2     p90RSK12 3
RSK12 3 5     p90S6K2 3
Ribosomal S6 Kinase 12 3     EC 2.7.11.13 8
90 KDa Ribosomal Protein S6 Kinase 12 3     Ribosomal Protein S6 Kinase, 90kD, Polypeptide 11
MAPKAPK-1a2 3     HU-12
MAPKAPK1A2 3     RSK2
RSK-12 3     DJ590P13.1 (Ribosomal Protein S6 Kinase, 90kD, Polypeptide 1)2
S6K-alpha-12 3     Ribosomal Protein S6 Kinase Alpha 12
MAP Kinase-Activated Protein Kinase 1a2 3     Ribosomal Protein S6 Kinase Alpha-12
MAPK-Activated Protein Kinase 1a2 3     S6K-Alpha 12
MAPKAP Kinase 1a2 3     EC 2.7.118
P90-RSK 12 3     

External Ids:    HGNC: 104301   Entrez Gene: 61952   Ensembl: ENSG000001176767   OMIM: 6016845   UniProtKB: Q154183   

Export aliases for RPS6KA1 gene to outside databases

Previous GC identifers: GC01P028654 GC01P025888 GC01P026089 GC01P026460 GC01P026540 GC01P026728 GC01P025110


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for RPS6KA1 Gene:
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase
contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the
mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in
controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different
isoforms, have been characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for RPS6KA1 Gene:
RPS6KA1 (ribosomal protein S6 kinase, 90kDa, polypeptide 1) is a protein-coding gene. Diseases associated with RPS6KA1 include coffin-lowry syndrome, and tuberous sclerosis. GO annotations related to this gene include protein serine/threonine kinase activity and cysteine-type endopeptidase inhibitor activity involved in apoptotic process. An important paralog of this gene is RPS6KA6.

UniProtKB/Swiss-Prot: KS6A1_HUMAN, Q15418
Function: Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and
mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77,
regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and
differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In
fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent
transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA),
phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon
insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B
at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent
mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex. In response
to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent
translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798',
which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which
regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway.
Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their
pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to
the hepatotoxin carbon tetrachloride (CCl4). Is involved in cell cycle regulation by phosphorylating the CDK
inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the
nucleus and inhibition of G1 progression

summary for RPS6KA1 Gene:
p90 ribosomal S6 kinases (RSKs) are a family of protein serine/threonine kinases that regulate diverse
cellular processes such as cell growth, motility, survival and proliferation. There are four isoforms of
this enzyme; RSK1-4, which are directly activated by ERK1/2 in response to growth factors, many polypeptide
hormones, neurotransmitters and chemokines. p90 RSKs phosphorylate numerous cytosolic and nuclear targets
and act as downstream effectors of the ERK/MAPK signaling cascade. They are expressed ubiquitously in human
tissues and exist in multiple subcellular compartments. Abberant activation of p90 RSKs has been linked to
many human diseases, including breast and prostate cancers.

Gene Wiki entry for RPS6KA1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPS6KA1 gene promoter:
         C/EBPbeta   Elk-1   NF-kappaB   NF-kappaB1   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RPS6KA1 promoter sequence
   Search Chromatin IP Primers for RPS6KA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPS6KA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p

RPS6KA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS6KA1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P026856:  view genomic region     (about GC identifiers)

Start:
26,856,249 bp from pter      End:
26,901,521 bp from pter
Size:
45,273 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: KS6A1_HUMAN, Q15418 (See protein sequence)
Recommended Name: Ribosomal protein S6 kinase alpha-1  
Size: 735 amino acids; 82723 Da
Cofactor: Magnesium
Subunit: Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells. Transiently dissociates
following mitogenic stimulation. Interacts with ETV1/ER81 and FGFR1
Selected PDB 3D structures from and Proteopedia for RPS6KA1 (see all 7):
2WNT (3D)        2Z7Q (3D)        2Z7R (3D)        2Z7S (3D)        3RNY (3D)        3TEI (3D)    
Secondary accessions: A6NGG4 A8K9K7 B2RDY8 B7Z5J0 Q5SVM5 Q5SVM8 Q5SVM9 Q96C05 Q9BQK2
Alternative splicing: 3 isoforms:  Q15418-1   Q15418-2   Q15418-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RPS6KA1: NX_Q15418

Explore proteomics data for RPS6KA1 at MOPED

Post-translational modifications: 

  • Activated by phosphorylation at Ser-221 by PDPK1. Autophosphorylated on Ser-380, as part of the activation
    process. May be phosphorylated at Thr-359 and Ser-363 by MAPK1/ERK2 and MAPK3/ERK11
  • N-terminal myristoylation results in an activated kinase in the absence of added growth factors1
  • Ubiquitination2 at Lys66, Lys75, Lys278, Lys316, Lys500, Lys562, Lys587, Lys654
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for RPS6KA1 (Q15418) (see all 50)
     VVHRDLK  DKILRQK  CDIWSLG  KLTDFGL 


    See RPS6KA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001006666.1  NP_002944.2  

    ENSEMBL proteins: 
     ENSP00000434616   ENSP00000436990   ENSP00000363283   ENSP00000363281   ENSP00000431651  
     ENSP00000433039   ENSP00000432281   ENSP00000355831   ENSP00000363278   ENSP00000435412  
     ENSP00000383967   ENSP00000403548   ENSP00000363277  
    Reactome Protein details: Q15418

    RPS6KA1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant RPS6KA1 Protein
    R&D Systems Recombinant & Natural Proteins for RPS6KA1 (RSK1)
    Enzo Life Sciences proteins for RPS6KA1
    OriGene Purified Protein for RPS6KA1
    OriGene Protein Over-expression Lysate for RPS6KA1
    OriGene MassSpec for RPS6KA1
    OriGene Custom Protein Services for RPS6KA1
    GenScript Custom Purified and Recombinant Proteins Services for RPS6KA1
    Novus Biologicals RPS6KA1 Proteins
    Novus Biologicals RPS6KA1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for RPS6KA1 

     
    antibodies-online proteins for RPS6KA1 (4 products) 

     
    antibodies-online peptides for RPS6KA1

    RPS6KA1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of RPS6KA1
    R&D Systems Antibodies for RPS6KA1 (RSK1)
    Cell Signaling Technology (CST) Antibodies for RPS6KA1  (p90RSK)
    OriGene Antibodies for RPS6KA1
    OriGene Custom Antibody Services for RPS6KA1
    Novus Biologicals RPS6KA1 Antibodies
    Abcam antibodies for RPS6KA1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for RPS6KA1
    antibodies-online antibodies for RPS6KA1 (235 products) 

    RPS6KA1 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of RPS6KA1
    OriGene Custom Assay Services for RPS6KA1
    R&D Systems ELISAs for RPS6KA1 (RSK1)         (see all)
    GenScript Custom Assay Services for RPS6KA1
    Cell Signaling Technology (CST) Sandwich ELISA Kits for RPS6KA1 (p90RSK)
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for RPS6KA1 
    antibodies-online kits for RPS6KA1 (7 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    IUPHAR Guide to PHARMACOLOGY protein family classification: ribosomal protein S6 kinase, 90kDa, polypeptide 1
    RSK subfamily
    Other AGC kinases

    Selected InterPro protein domains (see all 8):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR000961 AGC-kinase_C
     IPR011009 Kinase-like_dom
     IPR017892 Pkinase_C

    Graphical View of Domain Structure for InterPro Entry Q15418

    ProtoNet protein and cluster: Q15418

    1 Blocks protein domain: IPB000961 Protein kinase C-terminal domain

    UniProtKB/Swiss-Prot: KS6A1_HUMAN, Q15418
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 2 protein kinase domains


    Find genes that share domains with RPS6KA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KS6A1_HUMAN, Q15418
    Function: Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and
    mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77,
    regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and
    differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In
    fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent
    transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA),
    phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon
    insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B
    at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent
    mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex. In response
    to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent
    translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798',
    which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which
    regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway.
    Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their
    pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to
    the hepatotoxin carbon tetrachloride (CCl4). Is involved in cell cycle regulation by phosphorylating the CDK
    inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the
    nucleus and inhibition of G1 progression
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Upon extracellular signal or mitogen stimulation, phosphorylated at Thr-573 in the C-terminal
    kinase domain (CTKD) by MAPK1/ERK2 and MAPK3/ERK1. The activated CTKD then autophosphorylates Ser-380, allowing
    binding of PDPK1, which in turn phosphorylates Ser-221 in the N-terminal kinase domain (NTDK) leading to the full
    activation of the protein and subsequent phosphorylation of the substrates by the NTKD

         Genatlas biochemistry entry for RPS6KA1:
    ribosomal protein S6 kinase,polypeptide 1,not involved in vivo in the phosphorylation of RPS6,mediating protein
    synthesis initiation and elongation induced by hormones or growth factors,maybe playing an essentilal regulatory
    role in protein synthesis during cell proliferation

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA10679322
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with RPS6KA1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for RPS6KA1:
     Decreased substrate adherent c  Increased cell death HMECs cel  Synthetic lethal with cisplati 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RPS6KA1

    miRNA
    Products:
        
    miRTarBase miRNAs that target RPS6KA1:
    hsa-mir-125b-5p (MIRT006430), hsa-mir-193b-3p (MIRT041478)

    Block miRNA regulation of human, mouse, rat RPS6KA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RPS6KA1 (see all 31):
    hsa-miR-125a-5p hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-302e hsa-miR-342-3p hsa-miR-520a-3p hsa-miR-4314
    SwitchGear 3'UTR luciferase reporter plasmidRPS6KA1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RPS6KA1
    Predesigned siRNA for gene silencing in human, mouse, rat RPS6KA1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RPS6KA1

    Clone
    Products:
         
    OriGene clones in human, mouse for RPS6KA1 (see all 13)
    OriGene ORF clones in mouse, rat for RPS6KA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RPS6KA1 (NM_002953)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPS6KA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS6KA1
    Addgene plasmids for RPS6KA1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RPS6KA1
    Browse ESI BIO Cell Lines and PureStem Progenitors for RPS6KA1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS6KA1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    KS6A1_HUMAN, Q15418: Nucleus. Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton2
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA--
    GO:0005819spindle IEA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with RPS6KA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for RPS6KA1 About   (see all 53)  
    See pathways by source

    SuperPathContained pathways About
    1MAPK targets/ Nuclear events mediated by MAP kinases
    ERK/MAPK targets0.88
    MAP kinase activation in TLR cascade0.61
    Nuclear Events (kinase and transcription factor activation)0.88
    MAP Kinase Signaling0.31
    MAPK targets/ Nuclear events mediated by MAP kinases0.80
    CREB phosphorylation0.00
    2Post NMDA receptor activation events
    Post NMDA receptor activation events0.90
    Long-term potentiation0.35
    Activation of NMDA receptor upon glutamate binding and postsynaptic events0.90
    RSK activation0.00
    CREB phosphorylation through the activation of Ras0.78
    3Development EGFR signaling pathway
    Development GDNF family signaling0.45
    BDNF Pathway0.39
    GDNF-Family Ligands and Receptor Interactions0.41
    4Translation Insulin regulation of translation
    Translation Insulin regulation of translation0.59
    mTOR signaling pathway0.34
    Regulation of lipid metabolism Insulin signaling generic cascades0.59
    5Development IGF 1 receptor signaling
    Development IGF RI signaling0.49
    Development IGF 1 receptor signaling0.48


    Find genes that share SuperPaths with RPS6KA1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RPS6KA1 (see all 23)
        FLT3 Signaling
    MAPK Signaling
    14-3-3 Induced Apoptosis
    Mitochondrial Apoptosis
    TRKA Signaling

    1 Cell Signaling Technology (CST) Pathway for RPS6KA1
        MAP Kinase Signaling

    5 Tocris Bioscience Pathways for RPS6KA1
        Insulin Pathway
    Apoptosis Pathway
    NF-kappaB Pathway
    MAPK Pathway
    mTOR Pathway

    Selected GeneGo (Thomson Reuters) Pathways for RPS6KA1 (see all 14)
        Development A2A receptor signaling
    Apoptosis and survival BAD phosphorylation
    Signal transduction PKA signaling
    Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
    Immune response IL-9 signaling pathway

    Selected BioSystems Pathways for RPS6KA1 (see all 13)
        EGFR1 Signaling Pathway
    Insulin Signaling
    BDNF signaling pathway
    IL-5 Signaling Pathway
    Kit Receptor Signaling Pathway

    Selected Reactome Pathways for RPS6KA1 (see all 7)
        CREB phosphorylation
    Recycling pathway of L1
    Senescence-Associated Secretory Phenotype (SASP)
    RSK activation
    Gastrin-CREB signalling pathway via PKC and MAPK


    Selected Kegg Pathways  (Kegg details for RPS6KA1) (see all 6):
        MAPK signaling pathway
    Oocyte meiosis
    mTOR signaling pathway
    Long-term potentiation
    Neurotrophin signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RPS6KA1: 
              mTOR Signaling in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RPS6KA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPS6KA1 (Q154181, 2, 3 ENSP000003632774) via UniProtKB, MINT, STRING, and/or I2D (see all 117)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDAH2O958652, 3MINT-8269417 I2D: score=2 
    ENSG00000206395O958652, 3MINT-8269417 I2D: score=2 
    ENSG00000225635O958652, 3MINT-8269417 I2D: score=2 
    ENSG00000226634O958652, 3MINT-8269417 I2D: score=2 
    ENSG00000227317O958652, 3MINT-8269417 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 30):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006468protein phosphorylation ----
    GO:0007049cell cycle IEA--

    Find genes that share ontologies with RPS6KA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for RPS6KA1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BRD 7389p90 ribosomal S6 kinase inhibitor[376382-11-5]
    PF 4708671S6K1 inhibitor[1255517-76-0]
    SL 0101-1Selective p90 ribosomal S6 kinase (RSK) inhibitor[77307-50-7]

    3 HMDB Compounds for RPS6KA1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    1 DrugBank Compound for RPS6KA1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Purvalanol A6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine (see all 2)212844-53-6target--10592235

    Selected Novoseek inferred chemical compound relationships for RPS6KA1 gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rapamycin 67.4 10 12668683 (2), 16819968 (2), 15963500 (1), 14653992 (1) (see all 6)
    threonine 60.1 10 18084084 (2), 11585927 (1), 12618428 (1), 15919995 (1) (see all 9)
    serine 53.8 12 18084084 (2), 11108839 (2), 11585927 (1), 12235136 (1) (see all 10)
    phosphoinositide 46.7 2 17617058 (1), 15910284 (1)
    pd 98,059 44.3 5 11237744 (1), 11278385 (1), 8939914 (1), 19718656 (1)
    phosphatidylinositol 42.9 5 12668683 (2), 11108839 (2), 16819968 (1)
    glycogen 31.7 2 11108839 (1), 17850214 (1)
    ly294002 27.7 2 11237744 (1)
    valproate 25.4 3 18677583 (2), 15269271 (1)
    cyclic amp 25 6 16738324 (2)



    Find genes that share compounds with RPS6KA1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RPS6KA1 gene (2 alternative transcripts): 
    NM_001006665.1  NM_002953.3  

    Unigene Cluster for RPS6KA1:

    Ribosomal protein S6 kinase, 90kDa, polypeptide 1
    Hs.149957  [show with all ESTs]
    Unigene Representative Sequence: BC014966
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000525525 ENST00000526040 ENST00000374168(uc001bmr.1 uc010ofe.1)
    ENST00000524436 ENST00000374166 ENST00000526792 ENST00000529454 ENST00000530003
    ENST00000366866 ENST00000531113(uc010off.1) ENST00000374163(uc001bms.1 uc009vsl.1)
    ENST00000530607 ENST00000531382 ENST00000525582 ENST00000527264 ENST00000474934
    ENST00000488985 ENST00000403732
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RPS6KA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RPS6KA1 (see all 31):
    hsa-miR-125a-5p hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-302e hsa-miR-342-3p hsa-miR-520a-3p hsa-miR-4314
    SwitchGear 3'UTR luciferase reporter plasmidRPS6KA1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RPS6KA1
    Predesigned siRNA for gene silencing in human, mouse, rat RPS6KA1
    Clone
    Products:
         
    OriGene clones in human, mouse for RPS6KA1 (see all 13)
    OriGene ORF clones in mouse, rat for RPS6KA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RPS6KA1 (NM_002953)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPS6KA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS6KA1
    Addgene plasmids for RPS6KA1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RPS6KA1
    OriGene qSTAR qPCR primer pairs in human, mouse for RPS6KA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RPS6KA1
      QuantiTect SYBR Green Assays in human, mouse, rat RPS6KA1
      QuantiFast Probe-based Assays in human, mouse, rat RPS6KA1

    Additional mRNA sequence: 

    AK092955.1 AK225672.1 AK292722.1 AK294818.1 AK299007.1 AK315730.1 BC014966.1 BC039069.1 
    L07597.1 

    13 DOTS entries:

    DT.115771  DT.100815795  DT.100815799  DT.91669729  DT.100724903  DT.121440109  DT.121440103  DT.75158566 
    DT.100025261  DT.92435857  DT.95098737  DT.95176807  DT.95114015 

    Selected AceView cDNA sequences (see all 246):

    BQ007911 BX115111 AI032766 BQ063412 BF849344 AI248135 BQ933350 BM705147 
    AI720046 BI030550 BM673274 BP367185 BM826042 BQ440925 CD742998 AL135618 
    BX354559 BM707116 BI222410 BM549979 BX488664 BX365771 BG878337 CA489540 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RPS6KA1 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^
    SP1:              -           -                       -           -                                                                       -                 -   
    SP2:                                                  -                                                                                   -                 -   
    SP3:                                                  -           -                                                                                             
    SP4:                                                                                                                                                            
    SP5:                          -                                                                                                                                 

    ExUns: 23 ^ 24 ^ 25 ^ 26
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for RPS6KA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RPS6KA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTTTCTAA
    RPS6KA1 Expression
    About this image


    RPS6KA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    RPS6KA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPS6KA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.149957
        Pathway & Disease-focused RT2 Profiler PCR Arrays including RPS6KA1: 
              mTOR Signaling in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RPS6KA1
    OriGene qSTAR qPCR primer pairs in human, mouse for RPS6KA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RPS6KA1
    QuantiTect SYBR Green Assays in human, mouse, rat RPS6KA1
    QuantiFast Probe-based Assays in human, mouse, rat RPS6KA1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS6KA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for RPS6KA1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rps6ka11 , 5 ribosomal protein S6 kinase polypeptide 11, 5 91.02(n)1
    98.5(a)1
      4 (66.37 cM)5
    201111  NM_009097.51  NP_033123.21 
     1338472905 
    chicken
    (Gallus gallus)
    Aves RPS6KA11 ribosomal protein S6 kinase, 90kDa, polypeptide 1 80.84(n)
    92.23(a)
      386579  NM_001109771.2  NP_001103241.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    88(a)
    69(a)
    1 ↔ many
    1 ↔ many
    GL343488.1(23-16731)
    AAWZ02037155(11978-18689)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.8562 X.laevis ribosomal protein S6 kinase II (S6KII) mRNA, more 76.32(n)    M20187.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rps6ka3a1 ribosomal protein S6 kinase, polypeptide 3a 70.55(n)
    77.95(a)
      338219  NM_212786.1  NP_997951.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta S6kII3 protein amino acid phosphorylation
    protein serine/threonine more
    57(a)
    (best of 2)
      20B1   --
    worm
    (Caenorhabditis elegans)
    Secernentea T01H8.1b3
    rskn-11
    Protein kinase C terminal domain3
    rskn-11
    63(a)
    (best of 3)3
    58.97(n)1
    62.73(a)1
      I(8582453-8585937)3
    1726471  NM_001026431.21  NP_001021602.11 


    ENSEMBL Gene Tree for RPS6KA1 (if available)
    TreeFam Gene Tree for RPS6KA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RPS6KA1 gene
    RPS6KA62  MAPKAPK32  MAPKAPK52  RPS6KA52  MAPKAPK22  RPS6KA42  MKNK12  MKNK22  
    RPS6KA32  RPS6KA22  
    Selected SIMAP similar genes for RPS6KA1 using alignment to 10 protein entries:     KS6A1_HUMAN (see all proteins) (see all similar genes):
    RPS6KA2    RPS6KA3    RPS6KA6    KIN27    RPS6KC1    DCLK3
    MAST4    PRKACB    CDC42BPA    PRKACA    DKFZp564L2416    PRKY
    PRKACG    RPS6KA5    RPS6KB1    CSNK2A3    AKT3    SGK2

    Find genes that share paralogs with RPS6KA1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RPS6KA1 (see all 934)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1510271741,2
    --26854270(+) TGAGCA/CCAGAA 1 -- us2k10--------
    rs1144560221,2
    C,F--26854317(+) ACTGCA/TGCCTA 1 -- us2k11Minor allele frequency- T:0.06NA 120
    rs1897471191,2
    --26854334(+) AGAGCA/GAGACT 1 -- us2k10--------
    rs778618351,2
    C--26854366(+) AAAATA/CTATAG 1 -- us2k12Minor allele frequency- C:0.10WA 120
    rs1916612331,2
    --26854412(+) ATATAC/TCTGAA 1 -- us2k10--------
    rs1410014241,2
    --26854503(+) GGTAGC/TAGAGC 1 -- us2k10--------
    rs1502068771,2
    --26854612(+) GAGCAC/TGTGGA 1 -- us2k10--------
    rs1844427011,2
    --26854664(+) AGATGA/GAGTCT 1 -- us2k10--------
    rs23160021,2
    C,F,A,H--26854674(-) tgggcA/Gacaga 1 -- us2k16Minor allele frequency- G:0.37NA WA 16
    rs1888867551,2
    --26854844(+) TGTTAA/GCCAGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RPS6KA1 (26856249 - 26901521 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RPS6KA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv202n71CNV Loss21882294
    nsv526179CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RPS6KA1
    DNA2.0 Custom Variant and Variant Library Synthesis for RPS6KA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601684    OMIM disorders: --

    2 diseases for RPS6KA1:    
    About MalaCards
    coffin-lowry syndrome    tuberous sclerosis

    1 disease from the University of Copenhagen DISEASES database for RPS6KA1:
    Coffin-Lowry syndrome

    Find genes that share disorders with RPS6KA1           About GenesLikeMe

    5 Novoseek inferred disease relationships for RPS6KA1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tuberous sclerosis 31.6 1 16738324 (1)
    cancer 0.646 6 15705904 (2), 19470470 (1), 17512736 (1)
    breast cancer 0 4 15705904 (2), 17512736 (1)
    tumors 0 3 19258500 (1), 15342917 (1)
    melanoma 0 2 14678993 (2)

    Genetic Association Database (GAD): RPS6KA1
    Human Genome Epidemiology (HuGE) Navigator: RPS6KA1 (8 documents)

    Export disorders for RPS6KA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RPS6KA1 gene, integrated from 10 sources (see all 258):
    (articles sorted by number of sources associating them with RPS6KA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human rsk isoforms: cloning and characterization of tissue-specific expression. (PubMed id 8141249)1, 2, 3, 9 Moller D.E.... Jakubowski M. (Am. J. Physiol. 1994)
    2. Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity. (PubMed id 12832467)1, 2, 9 Roux P.P.... Blenis J. (Mol. Cell. Biol. 2003)
    3. Crystal structures of the N-terminal kinase domain of human RSK1 bound to three different ligands: Implications for the design of RSK1 specific inhibitors. (PubMed id 17965187)1, 2, 9 Ikuta M....Munshi S.K. (Protein Sci. 2007)
    4. Regulation of the ETS transcription factor ER81 by the 90-kDa ribosomal S6 kinase 1 and protein kinase A. (PubMed id 12213813)1, 2, 9 Wu J. and Janknecht R. (J. Biol. Chem. 2002)
    5. Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK- mediated raptor phosphorylation. (PubMed id 18722121)1, 2, 9 Carriere A.... Roux P.P. (Curr. Biol. 2008)
    6. Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. (PubMed id 15342917)1, 2, 9 Roux P.P.... Blenis J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    7. Genetic variation in RPS6KA1, RPS6KA2, RPS6KB1, RPS6KB2, and PDK1 and risk of colon or rectal cancer. (PubMed id 21035469)1, 4 Slattery M.L....Wolff R.K. (Mutat. Res. 2011)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1, 4 Vega A....Carracedo A. (Gynecol. Oncol. 2009)
    10. The RSK family of kinases: emerging roles in cellular signalling. (PubMed id 18813292)1, 2 Anjum R. and Blenis J. (Nat. Rev. Mol. Cell Biol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 6195 HGNC: 10430 AceView: RPS6KA1 Ensembl:ENSG00000117676 euGenes: HUgn6195
    ECgene: RPS6KA1 Kegg: 6195 H-InvDB: RPS6KA1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RPS6KA1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RPS6KA1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RPS6KA1 gene:
    Search GeneIP for patents involving RPS6KA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     EMD Millipore Kits and Assays for the Analysis of RPS6KA1
     EMD Millipore Mono- and Polyclonal Antibodies for the study of RPS6KA1
     EMD Millipore Purified and/or Recombinant RPS6KA1 Protein
     
     EMD Millipore genomic analysis products

      
     Antibodies for RPS6KA1 (RSK1)   Browse Cell Culture Products  
     ELISAs for RPS6KA1 (RSK1)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for RPS6KA1 (RSK1)   Browse Stem Cell Products  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for RPS6KA1 (RSK1)  
     OriGene Antibodies for RPS6KA1   OriGene RNAi products in human, mouse, rat for RPS6KA1  
     OriGene qPCR primer pairs and template standards for RPS6KA1   OriGene Protein Over-expression Lysate for RPS6KA1  
     OriGene MassSpec for RPS6KA1   OriGene clones in human, mouse for RPS6KA1  
     OriGene qSTAR qPCR primer pairs in human, mouse for RPS6KA1   OriGene Purified Protein for RPS6KA1  
     OriGene ORF clones in mouse, rat for RPS6KA1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RPS6KA1   OriGene Custom Protein Services for RPS6KA1  

     
     
     Block miRNA regulation of human, mouse, rat RPS6KA1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RPS6KA1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPS6KA1 Predesigned siRNA for gene silencing in human, mouse, rat RPS6KA1
     QuantiFast Probe-based Assays in human, mouse, rat RPS6KA1 QuantiTect SYBR Green Assays in human, mouse, rat RPS6KA1
     PCR Arrays including human, mouse, rat RPS6KA1 Search Chromatin IP Primers for RPS6KA1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RPS6KA1  GeneGlobe Interaction Network for RPS6KA1
     Regulatory tfbs in RPS6KA1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for RPS6KA1 GenScript cDNA clones with any tag delivered in your preferred vector for RPS6KA1
     GenScript Custom Assay Services for RPS6KA1 GenScript Custom overexpressing Cell Line Services for RPS6KA1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for RPS6KA1  (p90RSK)

     Tocris compounds for RPS6KA1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for RPS6KA1
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RPS6KA1 antibodies
     RPS6KA1 proteins
     RPS6KA1 lysates
     Antibodies for RPS6KA1
     See all of Abcam's Antibodies, Kits and Proteins for RPS6KA1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for RPS6KA1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS6KA1
     SwitchGear 3'UTR luciferase reporter plasmids for RPS6KA1
     SwitchGear Promoter luciferase reporter plasmids for RPS6KA1
     ThermoFisher Antibody for RPS6KA1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS6KA1
     Browse compounds at ApexBio
     Addgene plasmids for RPS6KA1
      Search eBioscience for proteins for RPS6KA1
      Search eBioscience for elisas for RPS6KA1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for RPS6KA1
     antibodies-online antibodies for RPS6KA1 (235 products)
     antibodies-online kits for RPS6KA1 (7 products)
     antibodies-online peptides for RPS6KA1
     antibodies-online proteins for RPS6KA1 (4 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RPS6KA1 gene at Home site.
    Version: 3.12.248 16 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4