RPS6KA1 Gene
protein-coding GIFtS: 70
GCID: GC01P026856
|
|
ribosomal protein S6 kinase, 90kDa, polypeptide 1(Previous names: ribosomal protein S6 kinase, 90kD, polypeptide 1 )
| |
Aliases
for RPS6KA1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 11 2 | | MAPKAP Kinase 1a2 3 | | RSK11 2 3 5 | | P90-RSK 12 3 | | HU-11 2 | | P90RSK11 | | RSK1 2 | | P90S6K1 | | Ribosomal S6 Kinase 12 3 | | EC 2.7.11.13 8 | | 90 KDa Ribosomal Protein S6 Kinase 12 3 | | Ribosomal Protein S6 Kinase, 90kD, Polypeptide 11 | | MAPKAPK-1a2 3 | | DJ590P13.1 (Ribosomal Protein S6 Kinase, 90kD, Polypeptide 1)2 | | MAPKAPK1A2 3 | | Ribosomal Protein S6 Kinase Alpha 12 | | RSK-12 3 | | Ribosomal Protein S6 Kinase Alpha-12 | | S6K-Alpha-11 | | S6K-Alpha 12 | | MAP Kinase-Activated Protein Kinase 1a2 3 | | EC 2.7.118 | | MAPK-Activated Protein Kinase 1a2 3 | | |
Export aliases for RPS6KA1 gene to outside databasesPrevious GC identifers: GC01P028654 GC01P025888 GC01P026089 GC01P026460 GC01P026540 GC01P026728 GC01P025110 |
Summaries
for RPS6KA1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RPS6KA1:
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2nonidentical kinase catalytic domains and phosphorylates various substrates, including members of themitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controllingcell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have beencharacterized. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: KS6A1_HUMAN, Q15418Function: Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling andmediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77,regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, anddifferentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, isrequired for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation ofseveral immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activatesNR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectlyon the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity.Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiationby facilitating assembly of the preinitiation complex. In response to insulin, phosphorylates EIF4B, enhancing EIF4Baffinity for the EIF3 complex and stimulating cap-dependent translation. Is involved in the mTOR nutrient-sensingpathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTORsignaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitivesignaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro-apoptotic proteinsBAD and DAPK1 and suppressing their pro-apoptotic function. Promotes the survival of hepatic stellate cells byphosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4). Is involved in cell cycle regulationby phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents itstranslocation to the nucleus and inhibition of G1 progression
 summary
for RPS6KA1: p90 ribosomal S6 kinases (RSKs) are a family of protein serine/threonine kinases that regulate diverse
cellular processes such as cell growth, motility, survival and proliferation. There are four isoforms of
this enzyme; RSK1-4, which are directly activated by ERK1/2 in response to growth factors, many polypeptide
hormones, neurotransmitters and chemokines. p90 RSKs phosphorylate numerous cytosolic and nuclear targets
and act as downstream effectors of the ERK/MAPK signaling cascade. They are expressed ubiquitously in human
tissues and exist in multiple subcellular compartments. Abberant activation of p90 RSKs has been linked to
many human diseases, including breast and prostate cancers.
Gene Wiki entry for RPS6KA1
|
Genomic Views
for RPS6KA1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RPS6KA1 gene promoter:
C/EBPbeta Elk-1 NF-kappaB NF-kappaB1 HNF-4alpha1
Other transcription factors
Search SABiosciences Chromatin IP Primers for RPS6KA1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS6KA1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p Ensembl cytogenetic band: 1p36.11 HGNC cytogenetic band: 1pRPS6KA1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P026856: view genomic region
(about GC identifiers)
Start:
|
26,856,249 bp from pter |
End:
|
26,901,521 bp from pter |
Size:
|
45,273 bases |
Orientation:
|
plus strand |
|
Proteins
for RPS6KA1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KS6A1_HUMAN, Q15418 (See
protein sequence)Recommended Name: Ribosomal protein S6 kinase alpha-1 Size: 735 amino acids; 82723 Da
Cofactor: Magnesium
Subunit: Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells. Transiently dissociates followingmitogenic stimulation. Interacts with ETV1/ER81 and FGFR1
Subcellular location: Nucleus. Cytoplasm
6 PDB 3D structures from  and Proteopedia  for RPS6KA1:2WNT (3D)
2Z7Q (3D)
2Z7R (3D)
2Z7S (3D)
3RNY (3D)
3TEI (3D)
Secondary accessions: A6NGG4 A8K9K7 B2RDY8 B7Z5J0 Q5SVM5 Q5SVM8 Q5SVM9 Q96C05 Q9BQK2Alternative splicing: 3 isoforms: Q15418-1 Q15418-2 Q15418-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for RPS6KA1: NX_Q15418
Post-translational modifications:
Activated by phosphorylation at Ser-221 by PDPK1. Autophosphorylated on Ser-380, as part of the activation process. Maybe phosphorylated at Thr-359 and Ser-363 by MAPK1/ERK2 and MAPK3/ERK11
N-terminal myristoylation results in an activated kinase in the absence of added growth factors1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15418
4/50 DME Specific Peptides for RPS6KA1 (Q15418) (see all 50)
RPS6KA1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001006666.1 NP_002944.2
ENSEMBL proteins: ENSP00000434616 ENSP00000436990 ENSP00000363283 ENSP00000363281 ENSP00000431651 ENSP00000433039 ENSP00000432281 ENSP00000355831 ENSP00000363278 ENSP00000435412 ENSP00000383967 ENSP00000403548 ENSP00000363277 Reactome Protein details: Q15418
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
RPS6KA1 for ontologies About GeneDecksing
RPS6KA1 Antibody Products:
Assay Products for RPS6KA1: |
Protein
Domains /
Families
for RPS6KA1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RPS6KA1 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q15418ProtoNet protein and cluster: Q15418 1 Blocks protein family: IPB000961 Protein kinase C-terminal domain
UniProtKB/Swiss-Prot: KS6A1_HUMAN, Q15418Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamilySimilarity: Contains 1 AGC-kinase C-terminal domainSimilarity: Contains 2 protein kinase domains |
Function
for RPS6KA1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KS6A1_HUMAN, Q15418Function: Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling andmediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77,regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, anddifferentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, isrequired for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation ofseveral immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activatesNR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectlyon the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity.Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiationby facilitating assembly of the preinitiation complex. In response to insulin, phosphorylates EIF4B, enhancing EIF4Baffinity for the EIF3 complex and stimulating cap-dependent translation. Is involved in the mTOR nutrient-sensingpathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTORsignaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitivesignaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro-apoptotic proteinsBAD and DAPK1 and suppressing their pro-apoptotic function. Promotes the survival of hepatic stellate cells byphosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4). Is involved in cell cycle regulationby phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents itstranslocation to the nucleus and inhibition of G1 progressionCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Upon extracellular signal or mitogen stimulation, phosphorylated at Thr-573 in the C-terminal kinasedomain (CTKD) by MAPK1/ERK2 and MAPK3/ERK1. The activated CTKD then autophosphorylates Ser-380, allowing binding ofPDPK1, which in turn phosphorylates Ser-221 in the N-terminal kinase domain (NTDK) leading to the full activation ofthe protein and subsequent phosphorylation of the substrates by the NTKD Genatlas biochemistry entry for RPS6KA1:ribosomal protein S6 kinase,polypeptide 1,not involved in vivo in the phosphorylation of RPS6,mediating proteinsynthesis initiation and elongation induced by hormones or growth factors,maybe playing an essentilal regulatory rolein protein synthesis during cell proliferation
Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPS6KA1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPS6KA1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for RPS6KA1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS6KA1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS6KA1 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
RPS6KA1 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for RPS6KA1:
|
Pathways & Interactions
for RPS6KA1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/55 super-pathways (see all 55) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | TRAF6 Mediated Induction of proinflammatory cytokines | | | 2 | Axon guidance | | | 3 | Development_CNTF receptor signaling | | | 4 | Development EGFR signaling pathway | | | 5 | Post NMDA receptor activation events | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/13 EMD Millipore Pathways for RPS6KA1 (see all 13)
5/23 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RPS6KA1 (see all 23)
1 
Cell Signaling Technology (CST) Pathway for RPS6KA1
5 Tocris Bioscience Pathways for RPS6KA1
5/14  GeneGo (Thomson Reuters) Pathways for RPS6KA1 (see all 14)
5/12  BioSystems Pathways for RPS6KA1 (see all 12)
5/42 
Reactome Pathways for RPS6KA1 (see all 42)
5/6 
Kegg Pathways (Kegg details for RPS6KA1) (see all 6):
RPS6KA1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RPS6KA1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/84 Interacting proteins for RPS6KA1 (Q154181, 2, 3 ENSP000003632774) via UniProtKB, MINT, STRING, and/or I2D (see all 84)About this table
Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0002224 | toll-like receptor signaling pathway |
TAS | -- | | GO:0002755 | MyD88-dependent toll-like receptor signaling pathway |
TAS | -- | | GO:0002756 | MyD88-independent toll-like receptor signaling pathway |
TAS | -- | | GO:0007049 | cell cycle |
IEA | -- | | GO:0007165 | signal transduction |
TAS | 8141249 |
RPS6KA1 for ontologies About GeneDecksing
|
Drugs & Compounds
for RPS6KA1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
RPS6KA1 for compounds About GeneDecksing
Compounds for RPS6KA1 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| SL 0101-1 | Selective p90 ribosomal S6 kinase (RSK) inhibitor | [77307-50-7] |
3 HMDB Compounds for RPS6KA1 About this table
1 DrugBank Compound for RPS6KA1 About this table
| Compound | Synonyms |
CAS
# | Type | Actions | PubMed Ids |
|---|
| Purvalanol A | 6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine (see all 2) | 212844-53-6 | target | -- | 10592235 |
10/14 Novoseek chemical compound relationships for RPS6KA1 gene (see all 14) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| rapamycin |
67.4 |
10 |
12668683 (2), 16819968 (2), 15963500 (1), 14653992 (1) (see all 6) |
| threonine |
60.1 |
10 |
18084084 (2), 11585927 (1), 12618428 (1), 15919995 (1) (see all 9) |
| serine |
53.8 |
12 |
18084084 (2), 11108839 (2), 11585927 (1), 12235136 (1) (see all 10) |
| phosphoinositide |
46.7 |
2 |
17617058 (1), 15910284 (1) |
| pd 98,059 |
44.3 |
5 |
11237744 (1), 11278385 (1), 8939914 (1), 19718656 (1) |
| phosphatidylinositol |
42.9 |
5 |
12668683 (2), 11108839 (2), 16819968 (1) |
| glycogen |
31.7 |
2 |
11108839 (1), 17850214 (1) |
| ly294002 |
27.7 |
2 |
11237744 (1) |
| valproate |
25.4 |
3 |
18677583 (2), 15269271 (1) |
| cyclic amp |
25 |
6 |
16738324 (2) |
Search CenterWatch for drugs/clinical trials and news about RPS6KA1 / KS6A1
|
Transcripts
for RPS6KA1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RPS6KA1 gene (2 alternative transcripts): NM_001006665.1 NM_002953.3 Unigene Cluster for RPS6KA1: Ribosomal protein S6 kinase, 90kDa, polypeptide 1 Hs.149957 [show with all ESTs]Unigene Representative Sequence: BC01496618/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21): ENST00000525525 ENST00000526040 ENST00000374168(uc001bmr.1 uc010ofe.1)
ENST00000524436 ENST00000374166 ENST00000526792 ENST00000529454 ENST00000530003
ENST00000366866 ENST00000531113(uc010off.1) ENST00000374163(uc001bms.1 uc009vsl.1)
ENST00000530607 ENST00000531382 ENST00000525582 ENST00000527264 ENST00000474934
ENST00000488985 ENST00000403732
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPS6KA1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPS6KA1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): RPS6KA1 (NM_002953) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPS6KA1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS6KA1 |
Additional cDNA sequence: AK092955.1 AK225672.1 AK292722.1 AK294818.1 AK299007.1 AK315730.1 BC014966.1 BC039069.1 L07597.1 13 DOTS entries: DT.115771 DT.100815795 DT.100815799 DT.91669729 DT.100724903 DT.121440109 DT.121440103 DT.75158566 DT.100025261 DT.92435857 DT.95098737 DT.95176807 DT.95114015 24/246 AceView cDNA sequences (see all 246): BP367185 AI720046 BI222410 BX354559 BM705147 BI030550 BF849344 AI248135 CD742998 AI032766 BX115111 BQ440925 BM673274 AL135618 BM707116 BQ933350 BQ007911 BQ063412 BM826042 BG878337 AU125058 BI225903 BX406199 BG119463
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for RPS6KA1 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | ^ | 22a | · | 22b | ^ |
|---|
|
| SP1: | | | | | - | | | | - | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | |
| SP2: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | |
| SP3: | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 23 | ^ | 24 | ^ | 25 | ^ | 26 |
|---|
|
| SP1: | | | | | | | | | |
| SP2: | | | | | | | | | |
| SP3: | | | | | | | | | |
| SP4: | | | | | | | | | |
| SP5: | | | | | | | | |
ECgene alternative splicing isoforms for RPS6KA1
|
Expression
for RPS6KA1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RPS6KA1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCTTTCTAA
About this image
See RPS6KA1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RPS6KA1
SOURCE GeneReport for Unigene cluster: Hs.149957
SABiosciences Expression via Pathway-Focused PCR Arrays including RPS6KA1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPS6KA1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RPS6KA1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS6KA1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS6KA1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS6KA1 |
Orthologs
for RPS6KA1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RPS6KA1 gene from 8/27 species (see all 27) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
RPS6KA11 |
ribosomal protein S6 kinase, 90kDa, polypeptide 1 |
80.79(n)
92.23(a) |
|
386579 NM_001109771.2 NP_001103241.1 |
lizard
(Anolis carolinensis) |
Reptilia |
RPS6KA16 |
-- |
89(a) |
1 ↔ 1 |
GL343488.1(140-13546) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.8562 |
X.laevis ribosomal protein S6 kinase II (S6KII) mRNA, more |
76.32(n) |
|
M20187.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
rps6ka3a1 |
ribosomal protein S6 kinase, polypeptide 3a |
70.55(n)
77.95(a) |
|
338219 NM_212786.1 NP_997951.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
S6kII3 |
protein amino acid phosphorylation protein
serine/threonine more |
57(a)
(best of 2) |
|
20B1 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
T01H8.1b3
rskn-11 |
Protein kinase C terminal domain3
Protein RSKN-11 |
63(a)
(best of 3)3
59.53(n)1
62.94(a)1 |
|
I(8582453-8585937)3
1726471 NM_001026431.11 NP_001021602.11 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
S6K26ATPK16 |
serine/threonine-protein kinase AtPK1/AtPK6 |
33(a)32(a) |
many ↔ manymany ↔ many |
3(2648509-2651160) 3(2651447-2654212) |
rice
(Oryza sativa) |
Liliopsida |
---- |
AGC_AGC_other_RS6K_like.1 - ACG kinases include ho...AGC_AGC_other_RS6K_like.2 - ACG kinases include ho... |
34(a)34(a) |
many ↔ manymany ↔ many |
3(12338898-12343059) 7(28854803-28858816) |
ENSEMBL Gene Tree for RPS6KA1 (if available)
TreeFam Gene Tree for RPS6KA1 (if available) |
Paralogs
for RPS6KA1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RPS6KA1 gene
- AKT12 RPS6KA62 RPS6KB12 SGK32 SGK22 AKT32 RPS6KA52 RPS6KA42
- SGK12 RPS6KB22 AKT22 RPS6KA32 RPS6KA22
18/139 SIMAP similar genes for RPS6KA1 using alignment to 10 protein entries: KS6A1_HUMAN (see all proteins)
(see all similar genes):RPS6KA2 RPS6KA3 RPS6KA6 KIN27 RPS6KC1 DCLK3
MAST4 PRKACB CDC42BPA PRKACA DKFZp564L2416 PRKY
PRKACG RPS6KA5 RPS6KB1 AKT3 SGK2 PKN2
RPS6KA1 for paralogs About GeneDecksing
|
Genomic Variants
for RPS6KA1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RPS6KA1 (26856249 - 26901521 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for RPS6KA1
2 CNVs: 84148 74423
1 Indel: 74424 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPS6KA1 |
|
Disorders
/ Diseases
for RPS6KA1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RPS6KA1 for disorders About GeneDecksing
OMIM gene information: 601684
OMIM disorders: --
20/23  diseases for RPS6KA1 (see all 23): About MalaCardscoffin-lowry syndrome prostate cancer prostatitis tuberous sclerosis
amyotrophic lateral sclerosis lateral sclerosis estrogen resistance sporadic breast cancer
kaposi's sarcoma breast cancer gout noma
sarcoma melanoma astrocytoma lung cancer
fibrosis thyroiditis hepatitis leukemia
1 disease from the University of Copenhagen DISEASES database for RPS6KA1:Coffin-Lowry syndrome 5 Novoseek disease relationships for RPS6KA1 gene About this table
Human Genome Epidemiology (HuGE) Navigator: RPS6KA1 (8 documents)
Export disorders for RPS6KA1 gene to outside databases
|
Publications
for RPS6KA1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RPS6KA1 gene, integrated from 9 sources (see all 250):
(articles sorted by number of sources associating them with RPS6KA1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human rsk isoforms: cloning and characterization of tissue-specific expression. (PubMed id 8141249)1, 2, 3, 9 Moller D.E.... Jakubowski M. (1994)
- Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity. (PubMed id 12832467)1, 2, 9 Roux P.P.... Blenis J. (2003)
- Crystal structures of the N-terminal kinase domain of human RSK1 bound to three different ligands: Implications for the design of RSK1 specific inhibitors. (PubMed id 17965187)1, 2, 9 Ikuta M....Munshi S.K. (2007)
- Regulation of the ETS transcription factor ER81 by the 90-kDa ribosomal S6 kinase 1 and protein kinase A. (PubMed id 12213813)1, 2, 9 Wu J. and Janknecht R. (2002)
- Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation. (PubMed id 18722121)1, 2, 9 Carriere A....Roux P.P. (2008)
- Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. (PubMed id 15342917)1, 2, 9 Roux P.P....Blenis J. (2004)
- The RSK family of kinases: emerging roles in cellular signalling. (PubMed id 18813292)1, 2 Anjum R. and Blenis J. (2008)
- Nur77 is phosphorylated in cells by RSK in response to mitogenic stimulation. (PubMed id 16223362)1, 2 Wingate A.D....Arthur J.S. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The tumor suppressor DAP kinase is a target of RSK-mediated survival signaling. (PubMed id 16213824)1, 2 Anjum R....Blenis J. (2005)
|
External Searches for RPS6KA1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RPS6KA1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RPS6KA1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RPS6KA1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for RPS6KA1 gene:
Search GeneIP for patents involving RPS6KA1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RPS6KA1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for RPS6KA1 | | OriGene shRNA RFP for RPS6KA1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPS6KA1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPS6KA1 | | | OriGene Protein Over-expression Lysate for RPS6KA1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RPS6KA1 | | OriGene 3'-UTR Clone for RPS6KA1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPS6KA1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPS6KA1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RPS6KA1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RPS6KA1 | | OriGene Custom Protein Services for RPS6KA1 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RPS6KA1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPS6KA1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS6KA1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS6KA1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS6KA1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS6KA1 |
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| | Antibodies & Assays for RPS6KA1 (p90RSK) |
| | | |  |  |  |  | | | | |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS6KA1 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS6KA1 |
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