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Aliases for RPS6 Gene

Aliases for RPS6 Gene

  • Ribosomal Protein S6 2 3
  • Phosphoprotein NP33 2 3 4
  • 40S Ribosomal Protein S6 2 3
  • S6 3

External Ids for RPS6 Gene

Summaries for RPS6 Gene

Entrez Gene Summary for RPS6 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS6 Gene

RPS6 (Ribosomal Protein S6) is a Protein Coding gene. Diseases associated with RPS6 include tuberous sclerosis and hemimegalencephaly. Among its related pathways are PI3K-Akt signaling pathway and Signaling by GPCR. GO annotations related to this gene include protein kinase binding and structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPS6 Gene

  • May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS6 Gene

Genomics for RPS6 Gene

Genomic Location for RPS6 Gene

Start:
19,375,715 bp from pter
End:
19,380,254 bp from pter
Size:
4,540 bases
Orientation:
Minus strand

Genomic View for RPS6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPS6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS6 Gene

Regulatory Elements for RPS6 Gene

Proteins for RPS6 Gene

  • Protein details for RPS6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62753-RS6_HUMAN
    Recommended name:
    40S ribosomal protein S6
    Protein Accession:
    P62753
    Secondary Accessions:
    • P08227
    • P10660
    • Q4VBY7
    • Q8N6Z7

    Protein attributes for RPS6 Gene

    Size:
    249 amino acids
    Molecular mass:
    28681 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS6 Gene

neXtProt entry for RPS6 Gene

Proteomics data for RPS6 Gene at MOPED

Post-translational modifications for RPS6 Gene

  • Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest. Phosphorylated at Ser-235 and Ser-236 by RPS6KA1 and RPS6KA3; phosphorylation at these sites facilitates the assembly of the preinitiation complex.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys14, Lys46, Lys58, Lys64, Lys116, Lys143, Lys149, Lys203, and Lys211

Other Protein References for RPS6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RPS6 Gene

Domains for RPS6 Gene

Gene Families for RPS6 Gene

HGNC:
  • RPS :S ribosomal proteins

Protein Domains for RPS6 Gene

UniProtKB/Swiss-Prot:

RS6_HUMAN
Family:
  • Belongs to the ribosomal protein S6e family.:
    • P62753
genes like me logo Genes that share domains with RPS6: view

Function for RPS6 Gene

Molecular function for RPS6 Gene

GENATLAS Biochemistry: 40S ribosomal protein S6,28kDa,housekeeping gene
UniProtKB/Swiss-Prot Function: May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA

Gene Ontology (GO) - Molecular Function for RPS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA --
GO:0005515 protein binding IPI 16314389
GO:0019901 protein kinase binding IPI 21418524
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPS6: view
genes like me logo Genes that share phenotypes with RPS6: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPS6 Gene

Localization for RPS6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS6 Gene COMPARTMENTS Subcellular localization image for RPS6 gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1
lysosome 1
mitochondrion 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for RPS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA 21630459
GO:0005730 nucleolus IDA 8590812
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RPS6: view

Pathways for RPS6 Gene

SuperPathways for RPS6 Gene

Superpath Contained pathways
1 Influenza Viral RNA Transcription and Replication
2 Insulin receptor signalling cascade
3 Translation Insulin regulation of translation
4 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
5 CFTR translational fidelity (class I mutations)
.54
genes like me logo Genes that share pathways with RPS6: view

Gene Ontology (GO) - Biological Process for RPS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000028 ribosomal small subunit assembly IEA --
GO:0000082 G1/S transition of mitotic cell cycle IEA --
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0001890 placenta development IEA --
GO:0002309 T cell proliferation involved in immune response IEA --
genes like me logo Genes that share ontologies with RPS6: view

Compounds for RPS6 Gene

(29) Novoseek inferred chemical compound relationships for RPS6 Gene

Compound -log(P) Hits PubMed IDs
rapamycin 89.6 35
ly294002 70.1 4
wortmannin 66.9 5
phosphatidylinositol 64.9 2
threonine 50.8 2
genes like me logo Genes that share compounds with RPS6: view

Transcripts for RPS6 Gene

Unigene Clusters for RPS6 Gene

Ribosomal protein S6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPS6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - - -
SP5: -
SP6: - -
SP7:
SP8: - -

Relevant External Links for RPS6 Gene

GeneLoc Exon Structure for
RPS6
ECgene alternative splicing isoforms for
RPS6

Expression for RPS6 Gene

mRNA expression in normal human tissues for RPS6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS6 Gene

SOURCE GeneReport for Unigene cluster for RPS6 Gene Hs.408073

genes like me logo Genes that share expressions with RPS6: view

Orthologs for RPS6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPS6 36
  • 99.73 (n)
  • 100 (a)
RPS6 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 96 (a)
OneToMany
RPS6 36
  • 92.1 (n)
  • 99.6 (a)
RPS6 37
  • 99 (a)
OneToMany
RPS6 37
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 99 (a)
OneToMany
RPS6 36
  • 90.5 (n)
  • 100 (a)
RPS6 37
  • 100 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rps6 36
  • 87.82 (n)
  • 100 (a)
Rps6 16
Rps6 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RPS6 37
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPS6 37
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100911372 36
  • 88.89 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves RPS6 36
  • 82.46 (n)
  • 97.99 (a)
RPS6 37
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 98 (a)
OneToMany
-- 37
  • 94 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76307 36
rps6 36
  • 80.86 (n)
  • 96.39 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4344 36
zebrafish
(Danio rerio)
Actinopterygii -- 36
rps6 36
  • 78.58 (n)
  • 95.58 (a)
rps6 37
  • 96 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002919 36
  • 60.88 (n)
  • 71.61 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpS6 36
  • 65.86 (n)
  • 75.71 (a)
RpS6 37
  • 75 (a)
OneToOne
RpS6 38
  • 78 (a)
worm
(Caenorhabditis elegans)
Secernentea rps-6 36
  • 57.99 (n)
  • 60.16 (a)
rps-6 37
  • 60 (a)
OneToOne
rps-6 38
  • 62 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR197C 36
  • 59.46 (n)
  • 61.44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS6A 36
  • 61.72 (n)
  • 63.56 (a)
RPS6A 37
  • 63 (a)
OneToMany
RPS6A 39
RPS6B 37
  • 63 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E24047g 36
  • 61.58 (n)
  • 62.71 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6719 36
thale cress
(Arabidopsis thaliana)
eudicotyledons EMB3010 36
  • 60.5 (n)
  • 67.65 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.2106 36
corn
(Zea mays)
Liliopsida Zm.516 36
rice
(Oryza sativa)
Liliopsida Os07g0622100 36
  • 61.86 (n)
  • 67.8 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.28703 36
bread mold
(Neurospora crassa)
Ascomycetes NCU08502 36
  • 63.98 (n)
  • 70.76 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps601 36
  • 62.71 (n)
  • 70.34 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5356 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11154 37
  • 76 (a)
OneToOne
Species with no ortholog for RPS6:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPS6 Gene

ENSEMBL:
Gene Tree for RPS6 (if available)
TreeFam:
Gene Tree for RPS6 (if available)

Paralogs for RPS6 Gene

genes like me logo Genes that share paralogs with RPS6: view

No data available for Paralogs for RPS6 Gene

Variants for RPS6 Gene

Sequence variations from dbSNP and Humsavar for RPS6 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs957 -- 19,379,369(-) AGTTG(C/T)TTCCG intron-variant
rs983 -- 19,379,368(-) GTTGC(C/T)TCCGA intron-variant
rs1143622 -- 19,376,318(-) TACTT(C/G/T)TAAGT reference, missense
rs1804397 -- 19,378,835(-) GTCCG(C/T)CTGCT reference, synonymous-codon
rs2277151 -- 19,376,410(-) AACTG(C/T)TTGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPS6 Gene

Variant ID Type Subtype PubMed ID
nsv466286 CNV Gain 19166990

Relevant External Links for RPS6 Gene

HapMap Linkage Disequilibrium report
RPS6

Disorders for RPS6 Gene

(1) University of Copenhagen DISEASES for RPS6 Gene

(13) Novoseek inferred disease relationships for RPS6 Gene

Disease -log(P) Hits PubMed IDs
tuberous sclerosis 66.6 3
angiomyolipoma 38.4 3
tumors 28.1 12
cancer 24 3
glioblastoma 14.2 2
genes like me logo Genes that share disorders with RPS6: view

No data available for UniProtKB/Swiss-Prot for RPS6 Gene

Publications for RPS6 Gene

  1. Multisite phosphorylation of a synthetic peptide derived from the carboxyl terminus of the ribosomal protein S6. (PMID: 1985906) Brandon S.D. … Masaracchia R.A. (J. Biol. Chem. 1991) 3 23
  2. Identification of phosphoprotein NP33 as a nucleus-associated ribosomal S6 protein and its phosphorylation in hematopoietic cells. (PMID: 2334893) Macfarlane D.E. … Gailani D. (Cancer Res. 1990) 3 23
  3. Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM). (PMID: 12045200) Goncharova E.A. … Krymskaya V.P. (J. Biol. Chem. 2002) 3 23
  4. Nuclear and nucleolar targeting of human ribosomal protein S6. (PMID: 8590812) Schmidt C. … Kruppa J. (Mol. Biol. Cell 1995) 3 23
  5. RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation. (PMID: 17360704) Roux P.P. … Blenis J. (J. Biol. Chem. 2007) 4 23

Products for RPS6 Gene

Sources for RPS6 Gene

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