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Aliases for RPS6 Gene

Aliases for RPS6 Gene

  • Ribosomal Protein S6 2 3 5
  • Phosphoprotein NP33 2 3 4
  • 40S Ribosomal Protein S6 2
  • S6 3

External Ids for RPS6 Gene

Previous GeneCards Identifiers for RPS6 Gene

  • GC09M019706
  • GC09M019565
  • GC09M019190

Summaries for RPS6 Gene

Entrez Gene Summary for RPS6 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS6 Gene

RPS6 (Ribosomal Protein S6) is a Protein Coding gene. Diseases associated with RPS6 include tuberous sclerosis and vulvar intraepithelial neoplasia. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPS6 Gene

  • May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS6 Gene

Genomics for RPS6 Gene

Regulatory Elements for RPS6 Gene

Promoters for RPS6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPS6 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPS6 Gene

Chromosome:
9
Start:
19,375,715 bp from pter
End:
19,380,254 bp from pter
Size:
4,540 bases
Orientation:
Minus strand

Genomic View for RPS6 Gene

Genes around RPS6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS6 Gene

Proteins for RPS6 Gene

  • Protein details for RPS6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62753-RS6_HUMAN
    Recommended name:
    40S ribosomal protein S6
    Protein Accession:
    P62753
    Secondary Accessions:
    • P08227
    • P10660
    • Q4VBY7
    • Q8N6Z7

    Protein attributes for RPS6 Gene

    Size:
    249 amino acids
    Molecular mass:
    28681 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS6 Gene

neXtProt entry for RPS6 Gene

Proteomics data for RPS6 Gene at MOPED

Post-translational modifications for RPS6 Gene

  • Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest. Phosphorylated at Ser-235 and Ser-236 by RPS6KA1 and RPS6KA3; phosphorylation at these sites facilitates the assembly of the preinitiation complex.
  • Ubiquitination at Lys 14, Lys 46, Lys 58, Lys 64, Lys 116, Lys 143, Lys 149, Lys 203, and Lys 211
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS6 Gene

No data available for DME Specific Peptides for RPS6 Gene

Domains & Families for RPS6 Gene

Gene Families for RPS6 Gene

Protein Domains for RPS6 Gene

Graphical View of Domain Structure for InterPro Entry

P62753

UniProtKB/Swiss-Prot:

RS6_HUMAN :
  • Belongs to the ribosomal protein S6e family.
Family:
  • Belongs to the ribosomal protein S6e family.
genes like me logo Genes that share domains with RPS6: view

Function for RPS6 Gene

Molecular function for RPS6 Gene

GENATLAS Biochemistry:
40S ribosomal protein S6,28kDa,housekeeping gene
UniProtKB/Swiss-Prot Function:
May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.
genes like me logo Genes that share phenotypes with RPS6: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS6 Gene

Localization for RPS6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS6 Gene COMPARTMENTS Subcellular localization image for RPS6 gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 2
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1
lysosome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for RPS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 2334893
GO:0005829 cytosol TAS --
GO:0015935 small ribosomal subunit IDA 15590835
GO:0016020 membrane IDA 19946888
GO:0030425 dendrite IEA,IDA 15121898
genes like me logo Genes that share ontologies with RPS6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS6 Gene

Pathways & Interactions for RPS6 Gene

SuperPathways for RPS6 Gene

Superpath Contained pathways
1 Viral mRNA Translation
.60
2 Interleukin-3, 5 and GM-CSF signaling
3 Translation Insulin regulation of translation
4 mTOR signalling
5 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
genes like me logo Genes that share pathways with RPS6: view

SIGNOR curated interactions for RPS6 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for RPS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IEA --
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing IEA,TAS --
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPS6: view

Drugs & Compounds for RPS6 Gene

(21) Drugs for RPS6 Gene - From: Novoseek and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
PX-866 Pharma Inhibition, inhibitor Kinase Inhibitors, Phosphatidylinositol-3- kinase (PI-3K) inhibitors 0

(9) Additional Compounds for RPS6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RPS6: view

Transcripts for RPS6 Gene

Unigene Clusters for RPS6 Gene

Ribosomal protein S6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPS6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - - -
SP5: -
SP6: - -
SP7:
SP8: - -

Relevant External Links for RPS6 Gene

GeneLoc Exon Structure for
RPS6
ECgene alternative splicing isoforms for
RPS6

Expression for RPS6 Gene

mRNA expression in normal human tissues for RPS6 Gene

Protein differential expression in normal tissues from HIPED for RPS6 Gene

This gene is overexpressed in Nasal epithelium (7.0) and Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS6 Gene



SOURCE GeneReport for Unigene cluster for RPS6 Gene Hs.408073

genes like me logo Genes that share expression patterns with RPS6: view

Protein tissue co-expression partners for RPS6 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS6 Gene

Orthologs for RPS6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPS6 35
  • 92.1 (n)
  • 99.6 (a)
-- 36
  • 96 (a)
OneToMany
RPS6 36
  • 99 (a)
OneToMany
RPS6 36
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RPS6 35
  • 90.5 (n)
  • 100 (a)
-- 36
  • 99 (a)
OneToMany
RPS6 36
  • 100 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rps6 35
  • 87.82 (n)
  • 100 (a)
Rps6 16
Rps6 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPS6 35
  • 99.73 (n)
  • 100 (a)
RPS6 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100911372 35
  • 88.89 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia RPS6 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPS6 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPS6 35
  • 82.46 (n)
  • 97.99 (a)
RPS6 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 98 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76307 35
rps6 35
  • 80.86 (n)
  • 96.39 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
rps6 35
  • 78.58 (n)
  • 95.58 (a)
rps6 36
  • 96 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4344 35
fruit fly
(Drosophila melanogaster)
Insecta RpS6 37
  • 78 (a)
RpS6 35
  • 65.86 (n)
  • 75.71 (a)
RpS6 36
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002919 35
  • 60.88 (n)
  • 71.61 (a)
worm
(Caenorhabditis elegans)
Secernentea rps-6 37
  • 62 (a)
rps-6 35
  • 57.99 (n)
  • 60.16 (a)
rps-6 36
  • 60 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR197C 35
  • 59.46 (n)
  • 61.44 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E24047g 35
  • 61.58 (n)
  • 62.71 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS6A 35
  • 61.72 (n)
  • 63.56 (a)
RPS6A 36
  • 63 (a)
OneToMany
RPS6B 36
  • 63 (a)
OneToMany
RPS6A 38
thale cress
(Arabidopsis thaliana)
eudicotyledons EMB3010 35
  • 60.5 (n)
  • 67.65 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6719 35
barley
(Hordeum vulgare)
Liliopsida Hv.2106 35
rice
(Oryza sativa)
Liliopsida Os07g0622100 35
  • 61.86 (n)
  • 67.8 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.28703 35
corn
(Zea mays)
Liliopsida Zm.516 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5356 35
bread mold
(Neurospora crassa)
Ascomycetes NCU08502 35
  • 63.98 (n)
  • 70.76 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps601 35
  • 62.71 (n)
  • 70.34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11154 36
  • 76 (a)
OneToOne
Species with no ortholog for RPS6:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPS6 Gene

ENSEMBL:
Gene Tree for RPS6 (if available)
TreeFam:
Gene Tree for RPS6 (if available)

Paralogs for RPS6 Gene

genes like me logo Genes that share paralogs with RPS6: view

No data available for Paralogs for RPS6 Gene

Variants for RPS6 Gene

Sequence variations from dbSNP and Humsavar for RPS6 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs17852447 - 19,376,381(+) TCTCC(C/T)TAGCC reference, missense
rs957 -- 19,379,369(-) AGTTG(C/T)TTCCG intron-variant
rs983 -- 19,379,368(-) GTTGC(C/T)TCCGA intron-variant
rs1143622 -- 19,376,318(-) TACTT(C/G/T)TAAGT reference, missense
rs1804397 -- 19,378,835(-) GTCCG(C/T)CTGCT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for RPS6 Gene

Variant ID Type Subtype PubMed ID
nsv466286 CNV Gain 19166990

Variation tolerance for RPS6 Gene

Residual Variation Intolerance Score: 24.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 5.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS6 Gene

HapMap Linkage Disequilibrium report
RPS6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS6 Gene

Disorders for RPS6 Gene

MalaCards: The human disease database

(5) MalaCards diseases for RPS6 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
tuberous sclerosis
  • bourneville's disease
vulvar intraepithelial neoplasia
  • vulvar intraepithelial tumor
hemimegalencephaly
  • macrencephaly
aplastic anemia
  • pulmonary fibrosis, idiopathic
subcorneal pustular dermatosis
  • sneddon-wilkinson disease or syndrome
- elite association - COSMIC cancer census association via MalaCards
Search RPS6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RPS6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPS6
genes like me logo Genes that share disorders with RPS6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS6 Gene

Publications for RPS6 Gene

  1. Substrate preference and phosphatidylinositol monophosphate inhibition of the catalytic domain of the Per-Arnt-Sim domain kinase PASKIN. (PMID: 21418524) Schlafli P. … Wenger R.H. (FEBS J. 2011) 3 4 67
  2. Anti-peptide antibodies for examining the conformation, molecular assembly and localization of an intracellular protein, ribosomal protein S6, in vivo. (PMID: 18039684) Nakagawa M. … Azuma T. (J. Biochem. 2008) 3 23
  3. Phospho-S6 ribosomal protein: a potential new predictive sarcoma marker for targeted mTOR therapy. (PMID: 18157089) Iwenofu O.H. … Brooks J.S. (Mod. Pathol. 2008) 3 23
  4. Resistance exercise decreases eIF2Bepsilon phosphorylation and potentiates the feeding-induced stimulation of p70S6K1 and rpS6 in young men. (PMID: 18565837) Glover E.I. … Phillips S.M. (Am. J. Physiol. Regul. Integr. Comp. Physiol. 2008) 3 23
  5. Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM). (PMID: 12045200) Goncharova E.A. … Krymskaya V.P. (J. Biol. Chem. 2002) 3 23

Products for RPS6 Gene

Sources for RPS6 Gene

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