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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPS6 Gene

protein-coding   GIFtS: 65
GCID: GC09M019366

Ribosomal Protein S6

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ribosomal Protein S61 2
Phosphoprotein NP331 2 3
40S Ribosomal Protein S61 2
S62

External Ids:    HGNC: 104291   Entrez Gene: 61942   Ensembl: ENSG000001371547   OMIM: 1804605   UniProtKB: P627533   

Export aliases for RPS6 gene to outside databases

Previous GC identifers: GC09M019706 GC09M019565 GC09M019190


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RPS6 Gene:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This
gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the
S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of
five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide
range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at
growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective
translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are
multiple processed pseudogenes of this gene dispersed through the genome. (provided by RefSeq, Jul 2008)

GeneCards Summary for RPS6 Gene: 
RPS6 (ribosomal protein S6) is a protein-coding gene. Diseases associated with RPS6 include tuberous sclerosis complex, and hemimegalencephaly, and among its related super-pathways are Eukaryotic Translation Initiation and Signal transduction AKT signaling. GO annotations related to this gene include structural constituent of ribosome and protein kinase binding.

UniProtKB/Swiss-Prot: RS6_HUMAN, P62753
Function: May play an important role in controlling cell growth and proliferation through the selective
translation of particular classes of mRNA




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008413.18  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPS6 gene promoter:
         USF1   Pbx1a   AP-1   USF-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPS6 promoter sequence
   Search SABiosciences Chromatin IP Primers for RPS6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p21   Ensembl cytogenetic band:  9p22.1   HGNC cytogenetic band: 9p21

RPS6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS6 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M019366:  view genomic region     (about GC identifiers)

Start:
19,375,713 bp from pter      End:
19,380,252 bp from pter
Size:
4,540 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RS6_HUMAN, P62753 (See protein sequence)
Recommended Name: 40S ribosomal protein S6  
Size: 249 amino acids; 28681 Da
1 PDB 3D structure from and Proteopedia for RPS6:
3J3A (3D)    
Secondary accessions: P08227 P10660 Q4VBY7 Q8N6Z7

Explore the universe of human proteins at neXtProt for RPS6: NX_P62753

Explore proteomics data for RPS6 at MOPED 

Post-translational modifications:

  • UniProtKB: Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is
    stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest.
    Phosphorylated at Ser-235 and Ser-236 by RPS6KA1 and RPS6KA3; phosphorylation at these sites facilitates the
    assembly of the preinitiation complex
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P62753

  • RPS6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RPS6 Protein Expression
    REFSEQ proteins: NP_001001.2  
    ENSEMBL proteins: 
     ENSP00000369757   ENSP00000369745   ENSP00000369743   ENSP00000369741  
    Reactome Protein details: P62753
    Human Recombinant Protein Products for RPS6: 
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    Novus Biologicals RPS6 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RPS6 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA2334893
    GO:0005730nucleolus IDA8590812
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--

    RPS6 for ontologies           About GeneDecksing



    RPS6 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of RPS6
    R&D Systems Antibodies for RPS6 (Ribosomal Protein S6/RPS6)
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    LSBio Antibodies in human, mouse, rat for RPS6 

    Assay Products for RPS6: 
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    GenScript Custom Assay Services for RPS6
    Cell Signaling Technology (CST) Sandwich ELISA Kits for RPS6 (S6)
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RPS6 
    Cloud-Clone Corp. CLIAs for RPS6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RPS: S ribosomal proteins

    3 InterPro protein domains:
     IPR018282 Ribosomal_S6e_CS
     IPR001377 Ribosomal_S6e
     IPR014401 Ribosomal_S6_euk

    Graphical View of Domain Structure for InterPro Entry P62753

    ProtoNet protein and cluster: P62753

    UniProtKB/Swiss-Prot: RS6_HUMAN, P62753
    Similarity: Belongs to the ribosomal protein S6e family


    RPS6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RS6_HUMAN, P62753
    Function: May play an important role in controlling cell growth and proliferation through the selective
    translation of particular classes of mRNA

         Genatlas biochemistry entry for RPS6:
    40S ribosomal protein S6,28kDa,housekeeping gene

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome IEA--
    GO:0005515protein binding IPI16314389
    GO:0019901protein kinase binding IPI--
         
    RPS6 for ontologies           About GeneDecksing


    Phenotypes:
         8 GenomeRNAi human phenotypes for RPS6:
     Decreased Hepatitis C virus re  Decreased cell number, increas  Decreased homologous recombina  Decreased viability 
     Decreased viability of wild-ty  Increased gamma-H2AX phosphory  Nucleolar pre-40S maturation d  S arrest 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rps6):
     cellular  endocrine/exocrine gland  homeostasis/metabolism  liver/biliary system 

    RPS6 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RPS6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RPS6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RPS6 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RPS6 

    miRNA
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    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RPS6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS6

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of RPS6

    Clone
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    GenScript: all cDNA clones in your preferred vector: RPS6 (NM_001010)
    Sino Biological Human cDNA Clone for RPS6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPS6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS6
    Sirion Biotech Customized lentivirus for stable overexpression of RPS6 
                         Customized lentivirus expression plasmids for stable overexpression of RPS6 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RPS6 About   (see all 33)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Viral mRNA Translation
    Influenza Life Cycle0.95
    L13a-mediated translational silencing of Ceruloplasmin expression0.93
    Influenza Infection0.95
    3' -UTR-mediated translational regulation0.93
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Formation of a pool of free 40S subunits0.90
    Eukaryotic Translation Termination0.94
    Nonsense-Mediated Decay0.84
    2Development IGF-RI signaling
    Development IGF-RI signaling0.49
    Development IGF-1 receptor signaling0.48
    Signal transduction AKT signaling0.49
    3Translation Insulin regulation of translation
    Translation Insulin regulation of translation0.59
    mTOR signaling pathway0.34
    Regulation of lipid metabolism Insulin signaling:generic cascades0.59
    Insulin signaling pathway0.31
    Transcription Receptor-mediated HIF regulation0.51
    4IRS-related events
    Insulin receptor signalling cascade0.94
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.92
    IRS-related events0.94
    IGF1R signaling cascade0.92
    IRS-related events triggered by IGF1R0.93
    PI3K Cascade0.86
    IRS-mediated signalling0.92
    Signaling by Insulin receptor0.79
    5Translation initiation complex formation
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.95
    Formation of the ternary complex, and subsequently, the 43S complex0.87
    Ribosomal scanning and start codon recognition0.95
    Translation initiation complex formation0.87

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 EMD Millipore Pathways for RPS6
        Translation Insulin regulation of translation
    Transcription Receptor-mediated HIF regulation
    Signal transduction AKT signaling
    Development IGF-RI signaling
    Regulation of lipid metabolism Insulin signaling-generic cascades

    1 R&D Systems Pathway for RPS6
        Adipocytokines & Insulin Signaling

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RPS6
        IGF1R Signaling
    Interferon Pathway
    mTOR Pathway
    Regulation of eIF4 and p70S6K
    Insulin Receptor Pathway

    1 Cell Signaling Technology (CST) Pathway for RPS6
        Translational Control

    5/6 GeneGo (Thomson Reuters) Pathways for RPS6 (see all 6)
        Translation Insulin regulation of translation
    Transcription Receptor-mediated HIF regulation
    Signal transduction AKT signaling
    Regulation of lipid metabolism Insulin signaling-generic cascades
    Development IGF-1 receptor signaling

    5/13 BioSystems Pathways for RPS6 (see all 13)
        Oncostatin M Signaling Pathway
    BDNF signaling pathway
    Cytoplasmic Ribosomal Proteins
    IL-2 Signaling pathway
    B Cell Receptor Signaling Pathway


    5/41        Reactome Pathways for RPS6 (see all 41)
        Formation of a pool of free 40S subunits
    S6K1 signalling
    Influenza Life Cycle
    mTORC1-mediated signalling
    IRS-mediated signalling


    5/6         Kegg Pathways  (Kegg details for RPS6) (see all 6):
        Ribosome
    HIF-1 signaling pathway
    mTOR signaling pathway
    PI3K-Akt signaling pathway
    Insulin signaling pathway


    RPS6 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RPS6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/548 Interacting proteins for RPS6 (P627531, 2, 3 ENSP000003697574) via UniProtKB, MINT, STRING, and/or I2D (see all 548)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPL26P612542, 3, ENSP000002938424MINT-6542674 MINT-8088269 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=4 STRING: ENSP00000293842
    RPL11P629132, 3, ENSP000003636764MINT-6542674 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=2 STRING: ENSP00000363676
    RPS3P233962, 3, ENSP000002785724MINT-6542674 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=2 STRING: ENSP00000278572
    RPS2P158802, 3, ENSP000003418854MINT-6542674 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=1 STRING: ENSP00000341885
    RPL35P427662, 3, ENSP000002594694MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=4 STRING: ENSP00000259469
    About this table

    Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000028ribosomal small subunit assembly IEA--
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006364rRNA processing IMP18697920
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--

    RPS6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RPS6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RPS6 (RS6)

    10/29 Novoseek inferred chemical compound relationships for RPS6 gene (see all 29)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rapamycin 89.6 49 19138981 (1), 19176369 (1), 15010863 (1), 17308050 (1) (see all 35)
    ly294002 70.1 4 13679036 (1), 12171932 (1), 19737348 (1), 15064379 (1)
    wortmannin 66.9 5 15504741 (1), 15010863 (1), 19906641 (1), 9249059 (1) (see all 5)
    phosphatidylinositol 64.9 2 12417714 (1), 19906641 (1)
    threonine 50.8 3 8018558 (1), 10490847 (1)
    serine 48.7 7 8018558 (1), 8015612 (1), 2159326 (1), 1848018 (1) (see all 7)
    leucine 37.7 11 10206976 (1), 19079937 (1), 19401455 (1), 12371905 (1) (see all 8)
    tyrosine 34 6 1611042 (1), 8397192 (1), 1848018 (1), 8179829 (1) (see all 6)
    glycogen 33.8 3 15504741 (1), 12371905 (1), 2203761 (1)
    phosphoserine 33.5 1 14987256 (1)

    Search CenterWatch for drugs/clinical trials and news about RPS6 / RS6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RPS6 gene: 
    NM_001010.2  

    Unigene Cluster for RPS6:

    Ribosomal protein S6
    Hs.408073  [show with all ESTs]
    Unigene Representative Sequence: AK093634
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380394(uc003znv.1) ENST00000498815 ENST00000380384 ENST00000315377(uc003znw.1)
    ENST00000380381
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPS6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS6
    Sirion Biotech Customized lentivirus for stable overexpression of RPS6 
                         Customized lentivirus expression plasmids for stable overexpression of RPS6 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS6

    Additional mRNA sequence: 

    AB062123.1 AK093634.1 AK291517.1 AK311861.1 BC000524.2 BC009427.2 BC013296.2 BC027620.1 
    BC035447.1 BC071907.1 BC071908.1 BC094826.1 J03537.1 M20020.1 

    24/179 DOTS entries (see all 179):

    DT.91782228  DT.100749323  DT.100749272  DT.91782227  DT.100749249  DT.99926832  DT.92016921  DT.99926814 
    DT.100749210  DT.91782145  DT.87013631  DT.100749107  DT.100749240  DT.95158540  DT.91782155  DT.95352254 
    DT.86998074  DT.100749062  DT.95320945  DT.100749252  DT.95158574  DT.91900579  DT.121149962  DT.91782168 

    24/4675 AceView cDNA sequences (see all 4675):

    BC000524 CA773203 BM477558 BM773293 BI908378 CA423374 AA358051 BQ917881 
    BU181792 BF976299 BM851684 AI280610 BE293815 BM855107 BQ214463 BU182661 
    BQ691525 CB069801 AI707548 BU194426 BM818333 CD368930 BQ640513 AI459571 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for RPS6 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b
    SP1:                    -     -                             -     -                                                   
    SP2:                    -     -     -                       -     -                                                   
    SP3:                          -                             -     -                                                   
    SP4:                    -     -     -                       -     -                       -                           
    SP5:                                                              -                                                   


    ECgene alternative splicing isoforms for RPS6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPS6 expression in normal human tissues (normalized intensities)      RPS6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCGTGTCCG
    RPS6 Expression
    About this image


    RPS6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/31 selected tissues (see all 31) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See RPS6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPS6

    SOURCE GeneReport for Unigene cluster: Hs.408073
        SABiosciences Expression via Pathway-Focused PCR Array including RPS6: 
              mTOR Signaling in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPS6 gene from 10/30 species (see all 30)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rps65 ribosomal protein S6   --   4 (40.69 cM) 86854660 
    chicken
    (Gallus gallus)
    Aves RPS61 ribosomal protein S6 82.46(n)
    97.99(a)
      396148  NM_205225.1  NP_990556.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    40S ribosomal protein S6
    98(a)
    94(a)
    possible ortholog
    possible ortholog
    2(62461302-62470296)
    GL343368.1(831098-831844)
    African clawed frog
    (Xenopus laevis)
    Amphibia L19996.12   -- 81.23(n)    L19996.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570923872   -- 78.24(n)   322551  57092387 
    fruit fly
    (Drosophila melanogaster)
    Insecta RpS61 , 3 protein biosynthesis structural
    constituent of more3
    Ribosomal protein S61
    78(a)3
    65.86(n)1
    75.71(a)1
      1 7C23
    317001  NM_078518.21  NP_511073.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rps-61 , 3 40S ribosomal protein S63
    Protein RPS-61
    62(a)3
    58.13(n)1
    60.16(a)1
      I(13960227-13961194)3
    1732601  NM_061034.51  NP_493435.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPS6A(YPL090C)4
    RPS6A1
    Protein component of the small (40S) ribosomal subunit; more4
    Rps6ap1
    61.72(n)1
    63.56(a)1
      16(378395-377291)4
    8560151, 4  NP_015235.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons EMB30101 40S ribosomal protein S6-2 60.5(n)
    67.65(a)
      830900  NM_121074.4  NP_196598.1 
    rice
    (Oryza sativa)
    Liliopsida AK061827.12   -- 73.98(n)    AK061827.1 


    ENSEMBL Gene Tree for RPS6 (if available)
    TreeFam Gene Tree for RPS6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPS6 gene

    RPS6 for paralogs           About GeneDecksing


    5/27 Pseudogenes.org Pseudogenes for RPS6 (see all 27)
    PGOHUM00000238625 PGOHUM00000238783 PGOHUM00000242878 PGOHUM00000239566 PGOHUM00000239610


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/251 SNPs in RPS6 are shown (see all 251)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs714968161,2
    C--19375839(+) AACTAGGTATCCAC
    TAAAACTA
    /-
    TGCCT
    1 -- ds50011Minor allele frequency- -:0.50NA 2
    rs1388861671,2
    --19375912(+) CATCTC/TCACAA 1 -- ds50010--------
    rs1839966161,2
    --19375943(+) ATTGTA/GTATAG 1 -- ds50010--------
    rs1886342271,2
    --19376000(+) TTAATA/CGTCCT 1 -- ds50010--------
    rs1817417451,2
    --19376017(+) TTCCCC/GTAAGT 1 -- ds50010--------
    rs101194651,2
    C,F,A,H--19376144(+) TCTGAC/TTTTAT 1 -- ds5001 ese324Minor allele frequency- T:0.25NS EA NA WA CSA 2323
    rs1133735061,2
    F--19376156(+) CACCAC/TTGGAA 1 -- ds50012Minor allele frequency- T:0.50CSA 4
    rs1153049261,2
    C,F--19376165(+) AATACC/TATATA 1 -- ds50011Minor allele frequency- T:0.08WA 118
    rs677105361,2
    C,F--19376255(+) AGATCA/CGAGTC 1 -- ut3112Minor allele frequency- C:0.16NA WA CSA EA NS EU 1112
    rs679068041,2
    C,F--19376258(+) TCAGAG/CTCTGA 1 -- ut3111Minor allele frequency- C:0.15NA WA CSA EA NS EU 1113

    HapMap Linkage Disequilibrium report for RPS6 (19375713 - 19380252 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RPS6:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv466286CNV Gain19166990

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 180460    OMIM disorders: --

    20/51 diseases for RPS6 (see all 51):    About MalaCards
    tuberous sclerosis complex    hemimegalencephaly    angiomyolipoma    tuberous sclerosis
    lymphangioleiomyomatosis    diamond-blackfan anemia    cervical squamous cell carcinoma    motor neuron disease
    aplastic anemia    congestive heart failure    herpes simplex    anaplastic large cell lymphoma
    acute promyelocytic leukemia    cutaneous t cell lymphoma    endometrial adenocarcinoma    chondrosarcoma
    gout    vaccinia    anemia    diffuse large b-cell lymphoma

    1 disease from the University of Copenhagen DISEASES database for RPS6:
    Cancer

    RPS6 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/13 Novoseek inferred disease relationships for RPS6 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tuberous sclerosis 66.6 3 16845579 (1), 12384518 (1), 19506736 (1)
    angiomyolipoma 38.4 3 12711473 (1), 16710343 (1), 16575396 (1)
    tumors 28.1 12 18157089 (3), 1454811 (2), 16818631 (1), 18048091 (1) (see all 9)
    cancer 24 3 19138981 (1), 16247451 (1), 20423992 (1)
    glioblastoma 14.2 2 19190119 (1), 19383977 (1)
    hypertrophy 12.9 2 15574430 (1), 19401455 (1)
    insulin sensitivity 5.04 1 18068701 (1)
    breast cancer 2.97 4 15289310 (2), 1837589 (1), 18829560 (1)
    shock 1.51 2 1880153 (1), 15292274 (1)
    carcinoma squamous cell 0 1 2174778 (1)


    Export disorders for RPS6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPS6 gene, integrated from 9 sources (see all 327):
    (articles sorted by number of sources associating them with RPS6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699)1, 2 Vladimirov S.N.... Otto A. (1996)
    4. The organization of the intron-containing human S6 ribosomal protein (rpS6) gene and determination of its location at chromosome 9p21. (PubMed id 1301164)1, 2 Antoine M. and Fried M. (1992)
    5. The human ribosomal protein S6 gene: isolation, primary structure and location in chromosome 9. (PubMed id 1446836)1, 2 Pata I.... Metspalu A. (1992)
    6. Isolation and characterization of cloned cDNAs that code for human ribosomal protein S6. (PubMed id 2840355)1, 2 Lott J.B. and Mackie G.A. (1988)
    7. The primary structure of the human ribosomal protein S6 derived from a cloned cDNA. (PubMed id 3279029)1, 2 Heinze H.... Kruppa J. (1988)
    8. RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation. (PubMed id 17360704)2, 9 Roux P.P....Blenis J. (2007)
    9. Identification of phosphoprotein NP33 as a nucleus-associated ribosomal S6 protein and its phosphorylation in hematopoietic cells. (PubMed id 2334893)1, 9 Macfarlane D.E. and Gailani D. (1990)
    10. Nuclear and nucleolar targeting of human ribosomal protein S6. (PubMed id 8590812)1, 9 Schmidt C....Kruppa J. (1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6194 HGNC: 10429 AceView: RPS6 Ensembl:ENSG00000137154 euGenes: HUgn6194
    ECgene: RPS6 Kegg: 6194 H-InvDB: RPS6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPS6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RPS6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RPS6 gene:
    Search GeneIP for patents involving RPS6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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