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Aliases for RPS6 Gene

Aliases for RPS6 Gene

  • Ribosomal Protein S6 2 3 5
  • Phosphoprotein NP33 2 3 4
  • 40S Ribosomal Protein S6 2 3
  • S6 3

External Ids for RPS6 Gene

Previous GeneCards Identifiers for RPS6 Gene

  • GC09M019706
  • GC09M019565
  • GC09M019190

Summaries for RPS6 Gene

Entrez Gene Summary for RPS6 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS6 Gene

RPS6 (Ribosomal Protein S6) is a Protein Coding gene. Diseases associated with RPS6 include Vulvar Intraepithelial Neoplasia and Aplastic Anemia. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Metabolism. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPS6 Gene

  • May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS6 Gene

Genomics for RPS6 Gene

Regulatory Elements for RPS6 Gene

Enhancers for RPS6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F019101 0.5 ENCODE 19.1 +277.8 277801 2.5 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF207 ZNF143 RPS6 HAUS6 PLIN2 ENSG00000201118
GH09F019441 1.2 Ensembl ENCODE 18.5 -61.5 -61533 1.2 IKZF1 MLLT1 TBX21 RPS6 NDUFA5P3 HAUS6 ENSG00000260912 PIR51132
GH09F019377 0.2 ENCODE 17.7 +0.7 732 4.2 HDGF PKNOX1 ARNT MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 RPS6 ENSG00000273226 SCARNA8 ENSG00000272842 GC09M019380 GC09M019381
GH09F018975 0.7 Ensembl ENCODE 11.7 +403.6 403603 1.7 PKNOX1 SIN3A FEZF1 GLI4 ZNF2 ZNF121 GLIS2 ZNF302 KLF7 ZNF263 ENSG00000273226 ENSG00000227167 ENSG00000270712 SCARNA8 SAXO1 RPS6 RPS6P10 HAUS6 PIR34932 LOC105375985
GH09F019251 0.4 Ensembl 7 +127.9 127854 1.2 KLF1 PKNOX1 SP3 RFX1 EBF1 ZBTB40 PPARG NR2F2 IKZF1 BCL6 HAUS6 RPS6 GC09P019231 ENSG00000232978
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RPS6 on UCSC Golden Path with GeneCards custom track

Promoters for RPS6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001301034 354 3001 HDGF PKNOX1 ARNT MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for RPS6 Gene

Chromosome:
9
Start:
19,375,715 bp from pter
End:
19,380,254 bp from pter
Size:
4,540 bases
Orientation:
Minus strand

Genomic View for RPS6 Gene

Genes around RPS6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS6 Gene

Proteins for RPS6 Gene

  • Protein details for RPS6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62753-RS6_HUMAN
    Recommended name:
    40S ribosomal protein S6
    Protein Accession:
    P62753
    Secondary Accessions:
    • P08227
    • P10660
    • Q4VBY7
    • Q8N6Z7

    Protein attributes for RPS6 Gene

    Size:
    249 amino acids
    Molecular mass:
    28681 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS6 Gene

neXtProt entry for RPS6 Gene

Post-translational modifications for RPS6 Gene

  • Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest. Phosphorylated at Ser-235 and Ser-236 by RPS6KA1 and RPS6KA3; phosphorylation at these sites facilitates the assembly of the preinitiation complex.
  • Ubiquitination at Lys 14, Lys 46, Lys 58, Lys 64, Lys 116, Lys 143, Lys 149, Lys 203, and Lys 211
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS6 Gene

No data available for DME Specific Peptides for RPS6 Gene

Domains & Families for RPS6 Gene

Gene Families for RPS6 Gene

Protein Domains for RPS6 Gene

Graphical View of Domain Structure for InterPro Entry

P62753

UniProtKB/Swiss-Prot:

RS6_HUMAN :
  • Belongs to the ribosomal protein S6e family.
Family:
  • Belongs to the ribosomal protein S6e family.
genes like me logo Genes that share domains with RPS6: view

Function for RPS6 Gene

Molecular function for RPS6 Gene

GENATLAS Biochemistry:
40S ribosomal protein S6,28kDa,housekeeping gene
UniProtKB/Swiss-Prot Function:
May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.

Gene Ontology (GO) - Molecular Function for RPS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA --
GO:0005515 protein binding IPI 16314389
GO:0019901 protein kinase binding IPI 21418524
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPS6: view
genes like me logo Genes that share phenotypes with RPS6: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RPS6

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS6 Gene

Localization for RPS6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS6 Gene COMPARTMENTS Subcellular localization image for RPS6 gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 2
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1
lysosome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for RPS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA 2334893
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA 8590812
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with RPS6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS6 Gene

Pathways & Interactions for RPS6 Gene

SuperPathways for RPS6 Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
.55
2 RET signaling
3 Translation Insulin regulation of translation
4 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
5 rRNA processing in the nucleus and cytosol
genes like me logo Genes that share pathways with RPS6: view

SIGNOR curated interactions for RPS6 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for RPS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IEA --
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0001890 placenta development IEA --
GO:0002309 T cell proliferation involved in immune response IEA --
GO:0006364 rRNA processing TAS --
genes like me logo Genes that share ontologies with RPS6: view

Drugs & Compounds for RPS6 Gene

(22) Drugs for RPS6 Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
PX-866 Pharma Inhibition, inhibitor Kinase Inhibitors, Phosphatidylinositol-3- kinase (PI-3K) inhibitors 0

(8) Additional Compounds for RPS6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RPS6: view

Transcripts for RPS6 Gene

Unigene Clusters for RPS6 Gene

Ribosomal protein S6:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RPS6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - - -
SP5: -
SP6: - -
SP7:
SP8: - -

Relevant External Links for RPS6 Gene

GeneLoc Exon Structure for
RPS6
ECgene alternative splicing isoforms for
RPS6

Expression for RPS6 Gene

mRNA expression in normal human tissues for RPS6 Gene

Protein differential expression in normal tissues from HIPED for RPS6 Gene

This gene is overexpressed in Nasal epithelium (7.0) and Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPS6 Gene



Protein tissue co-expression partners for RPS6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS6 Gene:

RPS6

SOURCE GeneReport for Unigene cluster for RPS6 Gene:

Hs.408073
genes like me logo Genes that share expression patterns with RPS6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS6 Gene

Orthologs for RPS6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPS6 34 35
  • 99.73 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 99 (a)
OneToMany
RPS6 34 35
  • 90.5 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RPS6 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 35
  • 96 (a)
OneToMany
RPS6 34 35 35
  • 92.1 (n)
rat
(Rattus norvegicus)
Mammalia LOC100911372 34
  • 88.89 (n)
mouse
(Mus musculus)
Mammalia Rps6 34 16 35
  • 87.82 (n)
oppossum
(Monodelphis domestica)
Mammalia RPS6 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPS6 34 35
  • 82.46 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 98 (a)
OneToMany
-- 35
  • 94 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rps6 34
  • 80.86 (n)
MGC76307 34
zebrafish
(Danio rerio)
Actinopterygii rps6 34 35
  • 78.58 (n)
-- 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4344 34
fruit fly
(Drosophila melanogaster)
Insecta RpS6 36 34 35
  • 65.86 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002919 34
  • 60.88 (n)
worm
(Caenorhabditis elegans)
Secernentea rps-6 36 34 35
  • 57.99 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS6B 35
  • 63 (a)
OneToMany
RPS6A 34 35 37
  • 61.72 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E24047g 34
  • 61.58 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR197C 34
  • 59.46 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons EMB3010 34
  • 60.5 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6719 34
rice
(Oryza sativa)
Liliopsida Os07g0622100 34
  • 61.86 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.2106 34
wheat
(Triticum aestivum)
Liliopsida Ta.28703 34
corn
(Zea mays)
Liliopsida Zm.516 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11154 35
  • 76 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU08502 34
  • 63.98 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps601 34
  • 62.71 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5356 34
Species where no ortholog for RPS6 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPS6 Gene

ENSEMBL:
Gene Tree for RPS6 (if available)
TreeFam:
Gene Tree for RPS6 (if available)

Paralogs for RPS6 Gene

No data available for Paralogs for RPS6 Gene

Variants for RPS6 Gene

Sequence variations from dbSNP and Humsavar for RPS6 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10119465 -- 19,376,146(+) TCTGA(C/T)TTTAT downstream-variant-500B
rs112043807 -- 19,381,940(+) GCTCT(G/T)AGCTC upstream-variant-2KB
rs112231732 -- 19,380,381(+) TGGGT(A/G)TGGGT upstream-variant-2KB
rs112244925 -- 19,380,538(+) GCATC(C/T)GACGG upstream-variant-2KB
rs113045318 -- 19,380,971(+) GGACT(A/G)TTTTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPS6 Gene

Variant ID Type Subtype PubMed ID
esv3619907 CNV gain 21293372
esv3619911 CNV gain 21293372
nsv1030736 CNV gain 25217958
nsv466286 CNV gain 19166990
nsv613730 CNV gain 21841781
nsv982199 CNV duplication 23825009

Variation tolerance for RPS6 Gene

Residual Variation Intolerance Score: 24.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 5.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPS6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS6 Gene

Disorders for RPS6 Gene

MalaCards: The human disease database

(3) MalaCards diseases for RPS6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
vulvar intraepithelial neoplasia
  • vulvar intraepithelial tumor
aplastic anemia
  • pulmonary fibrosis, idiopathic
subcorneal pustular dermatosis
  • sneddon-wilkinson disease or syndrome
- elite association - COSMIC cancer census association via MalaCards
Search RPS6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RPS6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPS6
genes like me logo Genes that share disorders with RPS6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS6 Gene

Publications for RPS6 Gene

  1. Substrate preference and phosphatidylinositol monophosphate inhibition of the catalytic domain of the Per-Arnt-Sim domain kinase PASKIN. (PMID: 21418524) Schlafli P. … Wenger R.H. (FEBS J. 2011) 3 4 64
  2. Resistance exercise decreases eIF2Bepsilon phosphorylation and potentiates the feeding-induced stimulation of p70S6K1 and rpS6 in young men. (PMID: 18565837) Glover E.I. … Phillips S.M. (Am. J. Physiol. Regul. Integr. Comp. Physiol. 2008) 3 22 64
  3. Anti-peptide antibodies for examining the conformation, molecular assembly and localization of an intracellular protein, ribosomal protein S6, in vivo. (PMID: 18039684) Nakagawa M. … Azuma T. (J. Biochem. 2008) 3 22 64
  4. Phospho-S6 ribosomal protein: a potential new predictive sarcoma marker for targeted mTOR therapy. (PMID: 18157089) Iwenofu O.H. … Brooks J.S. (Mod. Pathol. 2008) 3 22 64
  5. RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation. (PMID: 17360704) Roux P.P. … Blenis J. (J. Biol. Chem. 2007) 4 22 64

Products for RPS6 Gene

Sources for RPS6 Gene

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