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RPS6 Gene

protein-coding   GIFtS: 66
GCID: GC09M019366

Ribosomal Protein S6

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribosomal Protein S61 2
Phosphoprotein NP331 2 3
40S Ribosomal Protein S61 2
S62

External Ids:    HGNC: 104291   Entrez Gene: 61942   Ensembl: ENSG000001371547   OMIM: 1804605   UniProtKB: P627533   

Export aliases for RPS6 gene to outside databases

Previous GC identifers: GC09M019706 GC09M019565 GC09M019190


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RPS6 Gene:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This
gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the
S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of
five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide
range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at
growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective
translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are
multiple processed pseudogenes of this gene dispersed through the genome. (provided by RefSeq, Jul 2008)

GeneCards Summary for RPS6 Gene:
RPS6 (ribosomal protein S6) is a protein-coding gene. Diseases associated with RPS6 include hemimegalencephaly, and angiomyolipoma. GO annotations related to this gene include structural constituent of ribosome and protein kinase binding.

UniProtKB/Swiss-Prot: RS6_HUMAN, P62753
Function: May play an important role in controlling cell growth and proliferation through the selective
translation of particular classes of mRNA




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NC_018920.2  NT_008413.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPS6 gene promoter:
         USF1   Pbx1a   AP-1   USF-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPS6 promoter sequence
   Search Chromatin IP Primers for RPS6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPS6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p21   Ensembl cytogenetic band:  9p22.1   HGNC cytogenetic band: 9p21

RPS6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS6 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M019366:  view genomic region     (about GC identifiers)

Start:
19,375,713 bp from pter      End:
19,380,252 bp from pter
Size:
4,540 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RS6_HUMAN, P62753 (See protein sequence)
Recommended Name: 40S ribosomal protein S6  
Size: 249 amino acids; 28681 Da
1 PDB 3D structure from and Proteopedia for RPS6:
3J3A (3D)    
Secondary accessions: P08227 P10660 Q4VBY7 Q8N6Z7

Explore the universe of human proteins at neXtProt for RPS6: NX_P62753

Explore proteomics data for RPS6 at MOPED

Post-translational modifications: 

  • Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is
    stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest.
    Phosphorylated at Ser-235 and Ser-236 by RPS6KA1 and RPS6KA3; phosphorylation at these sites facilitates the
    assembly of the preinitiation complex1
  • Ubiquitination2 at Lys14, Lys46, Lys58, Lys64, Lys116, Lys143, Lys149, Lys203, Lys211
  • Modification sites at PhosphoSitePlus

  • See RPS6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001001.2  
    ENSEMBL proteins: 
     ENSP00000369757   ENSP00000369745   ENSP00000369743   ENSP00000369741  
    Reactome Protein details: P62753

    RPS6 Human Recombinant Protein Products:

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    Novus Biologicals RPS6 Protein
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for RPS6

    RPS6 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of RPS6
    R&D Systems Antibodies for RPS6 (Ribosomal Protein S6/RPS6)
    Cell Signaling Technology (CST) Antibodies for RPS6  (S6)
    OriGene Antibodies for RPS6
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    Novus Biologicals RPS6 Antibodies
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    RPS6 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RPS6
    Cloud-Clone Corp. CLIAs for RPS6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RPS: S ribosomal proteins

    3 InterPro protein domains:
     IPR018282 Ribosomal_S6e_CS
     IPR001377 Ribosomal_S6e
     IPR014401 Ribosomal_S6_euk

    Graphical View of Domain Structure for InterPro Entry P62753

    ProtoNet protein and cluster: P62753

    UniProtKB/Swiss-Prot: RS6_HUMAN, P62753
    Similarity: Belongs to the ribosomal protein S6e family


    RPS6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RS6_HUMAN, P62753
    Function: May play an important role in controlling cell growth and proliferation through the selective
    translation of particular classes of mRNA

         Genatlas biochemistry entry for RPS6:
    40S ribosomal protein S6,28kDa,housekeeping gene

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome IEA--
    GO:0005515protein binding IPI16314389
    GO:0019901protein kinase binding IPI--
    GO:0044822poly(A) RNA binding IDA--
         
    RPS6 for ontologies           About GeneDecksing


    Phenotypes:
         8 GenomeRNAi human phenotypes for RPS6:
     Decreased Hepatitis C virus re  Decreased cell number, increas  Decreased homologous recombina  Decreased viability 
     Decreased viability of wild-ty  Increased gamma-H2AX phosphory  Nucleolar pre-40S maturation d  S arrest 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rps6):
     cellular  endocrine/exocrine gland  homeostasis/metabolism  liver/biliary system 

    RPS6 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RPS6
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RPS6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RPS6

    miRNA
    Products:
        
    miRTarBase miRNAs that target RPS6:
    hsa-mir-182-3p (MIRT047174), hsa-mir-16-5p (MIRT003326), hsa-mir-652-3p (MIRT039518), hsa-mir-99a-5p (MIRT048636), hsa-let-7d-5p (MIRT051718), hsa-mir-15b-5p (MIRT046422), hsa-mir-1260b (MIRT052691), hsa-mir-744-5p (MIRT037442)

    Block miRNA regulation of human, mouse, rat RPS6 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate RPS6
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for RPS6
    Predesigned siRNA for gene silencing in human, mouse, rat RPS6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RPS6

    Clone
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    OriGene ORF clones in mouse, rat for RPS6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RPS6 (NM_001010)
    Sino Biological Human cDNA Clone for RPS6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPS6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS6

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5
    cytoskeleton1
    endoplasmic reticulum1
    extracellular1
    lysosome1
    mitochondrion1
    plasma membrane1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA2334893
    GO:0005730nucleolus IDA8590812
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--

    RPS6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RPS6 About   (see all 31)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CFTR translational fidelity class I mutations
    CFTR translational fidelity class I mutations 0.60
    Ribosome0.54
    Cytoplasmic Ribosomal Proteins0.60
    2Development IGF 1 receptor signaling
    Development IGF RI signaling0.49
    Development IGF 1 receptor signaling0.48
    Signal transduction AKT signaling0.49
    3Translation Insulin regulation of translation
    Translation Insulin regulation of translation0.59
    mTOR signaling pathway0.34
    Regulation of lipid metabolism Insulin signaling generic cascades0.59
    Insulin signaling pathway0.32
    Transcription Receptor mediated HIF regulation0.51
    4Influenza Viral RNA Transcription and Replication
    Viral mRNA Translation0.94
    Eukaryotic Translation Initiation0.89
    Peptide chain elongation0.94
    Cap-dependent Translation Initiation0.89
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    Formation of a pool of free 40S subunits0.94
    Nonsense-Mediated Decay0.89
    5Insulin receptor signalling cascade
    Insulin receptor signalling cascade0.94
    Signaling by Insulin receptor0.80
    IRS-related events0.94
    PKB-mediated events0.41
    IRS-mediated signalling0.92
    mTOR signalling0.39
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.92
    mTORC1-mediated signalling0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for RPS6
        Adipocytokines & Insulin Signaling

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RPS6
        IGF1R Signaling
    Interferon Pathway
    mTOR Pathway
    Regulation of eIF4 and p70S6K
    Insulin Receptor Pathway

    1 Cell Signaling Technology (CST) Pathway for RPS6
        Translational Control

    Selected GeneGo (Thomson Reuters) Pathways for RPS6 (see all 6)
        Translation Insulin regulation of translation
    Transcription Receptor-mediated HIF regulation
    Signal transduction AKT signaling
    Regulation of lipid metabolism Insulin signaling-generic cascades
    Development IGF-1 receptor signaling

    Selected BioSystems Pathways for RPS6 (see all 13)
        Oncostatin M Signaling Pathway
    BDNF signaling pathway
    Cytoplasmic Ribosomal Proteins
    B Cell Receptor Signaling Pathway
    IL-2 Signaling pathway


    Selected Reactome Pathways for RPS6 (see all 13)
        Peptide chain elongation
    Formation of the ternary complex, and subsequently, the 43S complex
    Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
    Viral mRNA Translation
    SRP-dependent cotranslational protein targeting to membrane


    Selected Kegg Pathways  (Kegg details for RPS6) (see all 6):
        Ribosome
    HIF-1 signaling pathway
    mTOR signaling pathway
    PI3K-Akt signaling pathway
    Insulin signaling pathway


    RPS6 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including RPS6: 
              mTOR Signaling in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RPS6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPS6 (P627531, 2, 3 ENSP000003697574) via UniProtKB, MINT, STRING, and/or I2D (see all 677)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPL26P612542, 3, ENSP000002938424MINT-6542674 MINT-8088269 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=4 STRING: ENSP00000293842
    RPL11P629132, 3, ENSP000003636764MINT-6542674 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=2 STRING: ENSP00000363676
    RPS3P233962, 3, ENSP000002785724MINT-6542674 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=2 STRING: ENSP00000278572
    RPS2P158802, 3, ENSP000003418854MINT-6542674 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=1 STRING: ENSP00000341885
    RPL35P427662, 3, ENSP000002594694MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=4 STRING: ENSP00000259469
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000028ribosomal small subunit assembly ----
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006364rRNA processing IMP18697920
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--

    RPS6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPS6 (RS6)

    Selected Novoseek inferred chemical compound relationships for RPS6 gene (see all 29)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rapamycin 89.6 49 19138981 (1), 19176369 (1), 15010863 (1), 17308050 (1) (see all 35)
    ly294002 70.1 4 13679036 (1), 12171932 (1), 19737348 (1), 15064379 (1)
    wortmannin 66.9 5 15504741 (1), 15010863 (1), 19906641 (1), 9249059 (1) (see all 5)
    phosphatidylinositol 64.9 2 12417714 (1), 19906641 (1)
    threonine 50.8 3 8018558 (1), 10490847 (1)
    serine 48.7 7 8018558 (1), 8015612 (1), 2159326 (1), 1848018 (1) (see all 7)
    leucine 37.7 11 10206976 (1), 19079937 (1), 19401455 (1), 12371905 (1) (see all 8)
    tyrosine 34 6 1611042 (1), 8397192 (1), 1848018 (1), 8179829 (1) (see all 6)
    glycogen 33.8 3 15504741 (1), 12371905 (1), 2203761 (1)
    phosphoserine 33.5 1 14987256 (1)



    RPS6 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RPS6 gene: 
    NM_001010.2  

    Unigene Cluster for RPS6:

    Ribosomal protein S6
    Hs.408073  [show with all ESTs]
    Unigene Representative Sequence: AK093634
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380394(uc003znv.1) ENST00000498815 ENST00000380384 ENST00000315377(uc003znw.1)
    ENST00000380381
    miRNA
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    Clone
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    OriGene ORF clones in mouse, rat for RPS6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RPS6 (NM_001010)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPS6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS6
    Primer
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    OriGene qPCR primer pairs and template standards for RPS6
    OriGene qSTAR qPCR primer pairs in human, mouse for RPS6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RPS6
      QuantiTect SYBR Green Assays in human, mouse, rat RPS6
      QuantiFast Probe-based Assays in human, mouse, rat RPS6

    Additional mRNA sequence: 

    AB062123.1 AK093634.1 AK291517.1 AK311861.1 BC000524.2 BC009427.2 BC013296.2 BC027620.1 
    BC035447.1 BC071907.1 BC071908.1 BC094826.1 J03537.1 M20020.1 

    Selected DOTS entries (see all 179):

    DT.91782228  DT.100749323  DT.100749272  DT.91782227  DT.100749249  DT.99926832  DT.92016921  DT.99926814 
    DT.100749210  DT.91782145  DT.87013631  DT.100749107  DT.100749240  DT.95158540  DT.91782155  DT.95352254 
    DT.86998074  DT.100749062  DT.95320945  DT.100749252  DT.95158574  DT.91900579  DT.121149962  DT.91782168 

    Selected AceView cDNA sequences (see all 4675):

    BQ776811 BQ056580 BQ057583 BM015078 BQ062243 BQ054532 BQ026577 BM915581 
    CB136127 BQ431997 F29306 BM142573 BM459236 AA358305 AA147356 BE791368 
    CB109425 BG759442 BQ432261 BE391131 CR622346 BP372528 AI685786 AI079241 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RPS6 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b
    SP1:                    -     -                             -     -                                                   
    SP2:                    -     -     -                       -     -                                                   
    SP3:                          -                             -     -                                                   
    SP4:                    -     -     -                       -     -                       -                           
    SP5:                                                              -                                                   


    ECgene alternative splicing isoforms for RPS6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RPS6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCGTGTCCG
    RPS6 Expression
    About this image


    RPS6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 24) fully expand
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; non-germinal center cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Primary Oocyte Primary Follicle
             Oviduct
     
     Epithelial Cells (Uncategorized)
             tonsil ; squamous epithelial cells   
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    RPS6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPS6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.408073
        Pathway & Disease-focused RT2 Profiler PCR Array including RPS6: 
              mTOR Signaling in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPS6 gene from Selected species (see all 30)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rps61 , 5 ribosomal protein S61, 5 87.82(n)1
    100(a)1
      4 (40.69 cM)5
    201041  NM_009096.31  NP_033122.11 
     868546605 
    chicken
    (Gallus gallus)
    Aves RPS61 ribosomal protein S6 82.46(n)
    97.99(a)
      396148  NM_205225.2  NP_990556.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    40S ribosomal protein S6
    98(a)
    94(a)
    many → 1
    many → 1
    2(62461302-62470296)
    GL343368.1(831098-831844)
    African clawed frog
    (Xenopus laevis)
    Amphibia L19996.12   -- 81.23(n)    L19996.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570923872   -- 78.24(n)   322551  57092387 
    fruit fly
    (Drosophila melanogaster)
    Insecta RpS61 , 3 protein biosynthesis structural
    constituent of more3
    Ribosomal protein S61
    78(a)3
    65.86(n)1
    75.71(a)1
      1 7C23
    317001  NM_078518.21  NP_511073.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rps-61 , 3 40S ribosomal protein S63
    rps-61
    62(a)3
    57.99(n)1
    60.16(a)1
      I(13960227-13961194)3
    1732601  NM_061034.61  NP_493435.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPS6A(YPL090C)4
    RPS6A1
    Protein component of the small (40S) ribosomal subunit; more4
    RPS6A1
    61.72(n)1
    63.56(a)1
      16(378395-377291)4
    8560151, 4  NP_015235.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons EMB30101 EMB3010 60.5(n)
    67.65(a)
      830900  NM_121074.4  NP_196598.1 
    rice
    (Oryza sativa)
    Liliopsida AK061827.12   -- 73.98(n)    AK061827.1 


    ENSEMBL Gene Tree for RPS6 (if available)
    TreeFam Gene Tree for RPS6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RPS6 gene

    RPS6 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for RPS6 (see all 27)
    PGOHUM00000238625 PGOHUM00000238783 PGOHUM00000242878 PGOHUM00000239566 PGOHUM00000239610


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RPS6 (see all 251)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs714968161,2
    C--19375839(+) AACTAGGTATCCAC
    TAAAACTA
    /-
    TGCCT
    1 -- ds50011Minor allele frequency- -:0.50NA 2
    rs1388861671,2
    --19375912(+) CATCTC/TCACAA 1 -- ds50010--------
    rs1839966161,2
    --19375943(+) ATTGTA/GTATAG 1 -- ds50010--------
    rs1886342271,2
    --19376000(+) TTAATA/CGTCCT 1 -- ds50010--------
    rs1817417451,2
    --19376017(+) TTCCCC/GTAAGT 1 -- ds50010--------
    rs101194651,2
    C,F,A,H--19376144(+) TCTGAC/TTTTAT 1 -- ds5001 ese324Minor allele frequency- T:0.25NS EA NA WA CSA 2323
    rs1133735061,2
    F--19376156(+) CACCAC/TTGGAA 1 -- ds50012Minor allele frequency- T:0.50CSA 4
    rs1153049261,2
    C,F--19376165(+) AATACC/TATATA 1 -- ds50011Minor allele frequency- T:0.08WA 118
    rs677105361,2
    C,F--19376255(+) AGATCA/CGAGTC 1 -- ut3112Minor allele frequency- C:0.16NA WA CSA EA NS EU 1112
    rs679068041,2
    C,F--19376258(+) TCAGAG/CTCTGA 1 -- ut3111Minor allele frequency- C:0.15NA WA CSA EA NS EU 1113

    HapMap Linkage Disequilibrium report for RPS6 (19375713 - 19380252 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RPS6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv466286CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RPS6
    DNA2.0 Custom Variant and Variant Library Synthesis for RPS6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 180460    OMIM disorders: --

    Selected diseases for RPS6 (see all 60):    
    About MalaCards
    hemimegalencephaly    angiomyolipoma    tuberous sclerosis    tuberous sclerosis complex
    lymphangioleiomyomatosis    diamond-blackfan anemia    cervical squamous cell carcinoma    motor neuron disease
    aplastic anemia    herpes simplex    congestive heart failure    anaplastic large cell lymphoma
    acute promyelocytic leukemia    cutaneous t cell lymphoma    endometrial adenocarcinoma    chondrosarcoma
    gout    vaccinia    diffuse large b-cell lymphoma    b-cell lymphomas

    1 disease from the University of Copenhagen DISEASES database for RPS6:
    Cancer

    RPS6 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for RPS6 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tuberous sclerosis 66.6 3 16845579 (1), 12384518 (1), 19506736 (1)
    angiomyolipoma 38.4 3 12711473 (1), 16710343 (1), 16575396 (1)
    tumors 28.1 12 18157089 (3), 1454811 (2), 16818631 (1), 18048091 (1) (see all 9)
    cancer 24 3 19138981 (1), 16247451 (1), 20423992 (1)
    glioblastoma 14.2 2 19190119 (1), 19383977 (1)
    hypertrophy 12.9 2 15574430 (1), 19401455 (1)
    insulin sensitivity 5.04 1 18068701 (1)
    breast cancer 2.97 4 15289310 (2), 1837589 (1), 18829560 (1)
    shock 1.51 2 1880153 (1), 15292274 (1)
    carcinoma squamous cell 0 1 2174778 (1)


    Export disorders for RPS6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RPS6 gene, integrated from 10 sources (see all 334):
    (articles sorted by number of sources associating them with RPS6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699)1, 2 Vladimirov S.N.... Otto A. (Eur. J. Biochem. 1996)
    4. The organization of the intron-containing human S6 ribosomal protein (rpS6) gene and determination of its location at chromosome 9p21. (PubMed id 1301164)1, 2 Antoine M. and Fried M. (Hum. Mol. Genet. 1992)
    5. The human ribosomal protein S6 gene: isolation, primary structure and location in chromosome 9. (PubMed id 1446836)1, 2 Pata I.... Metspalu A. (Gene 1992)
    6. Isolation and characterization of cloned cDNAs that code for human ribosomal protein S6. (PubMed id 2840355)1, 2 Lott J.B. and Mackie G.A. (Gene 1988)
    7. The primary structure of the human ribosomal protein S6 derived from a cloned cDNA. (PubMed id 3279029)1, 2 Heinze H.... Kruppa J. (J. Biol. Chem. 1988)
    8. RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation. (PubMed id 17360704)2, 9 Roux P.P.... Blenis J. (J. Biol. Chem. 2007)
    9. Identification of phosphoprotein NP33 as a nucleus-associated ribosomal S6 protein and its phosphorylation in hematopoietic cells. (PubMed id 2334893)1, 9 Macfarlane D.E. and Gailani D. (Cancer Res. 1990)
    10. Nuclear and nucleolar targeting of human ribosomal protein S6. (PubMed id 8590812)1, 9 Schmidt C....Kruppa J. (Mol. Biol. Cell 1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6194 HGNC: 10429 AceView: RPS6 Ensembl:ENSG00000137154 euGenes: HUgn6194
    ECgene: RPS6 Kegg: 6194 H-InvDB: RPS6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RPS6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RPS6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RPS6 gene:
    Search GeneIP for patents involving RPS6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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