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Aliases for RPS5 Gene

Aliases for RPS5 Gene

  • Ribosomal Protein S5 2 3
  • 40S Ribosomal Protein S5 2 3
  • S5 3

External Ids for RPS5 Gene

Summaries for RPS5 Gene

Entrez Gene Summary for RPS5 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS5 Gene

RPS5 (Ribosomal Protein S5) is a Protein Coding gene. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include RNA binding and mRNA binding.

Gene Wiki entry for RPS5 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS5 Gene

Genomics for RPS5 Gene

Genomic Location for RPS5 Gene

Start:
58,386,400 bp from pter
End:
58,394,806 bp from pter
Size:
8,407 bases
Orientation:
Plus strand

Genomic View for RPS5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPS5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS5 Gene

Regulatory Elements for RPS5 Gene

Proteins for RPS5 Gene

  • Protein details for RPS5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46782-RS5_HUMAN
    Recommended name:
    40S ribosomal protein S5
    Protein Accession:
    P46782
    Secondary Accessions:
    • B2R4T2
    • Q96BN0

    Protein attributes for RPS5 Gene

    Size:
    204 amino acids
    Molecular mass:
    22876 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS5 Gene

neXtProt entry for RPS5 Gene

Proteomics data for RPS5 Gene at MOPED

Post-translational modifications for RPS5 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys18, Lys22, Lys47, Lys63, Lys167, and Lys182

Other Protein References for RPS5 Gene

No data available for DME Specific Peptides for RPS5 Gene

Domains for RPS5 Gene

Gene Families for RPS5 Gene

HGNC:
  • RPS :S ribosomal proteins

Protein Domains for RPS5 Gene

UniProtKB/Swiss-Prot:

RS5_HUMAN
Family:
  • Belongs to the ribosomal protein S7P family.:
    • P46782
genes like me logo Genes that share domains with RPS5: view

Function for RPS5 Gene

Molecular function for RPS5 Gene

GENATLAS Biochemistry: 40S ribosomal protein S5

Gene Ontology (GO) - Molecular Function for RPS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding NAS 7772601
GO:0003729 mRNA binding IDA 18464793
GO:0003735 structural constituent of ribosome IDA 15883184
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPS5: view
genes like me logo Genes that share phenotypes with RPS5: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPS5 Gene

Localization for RPS5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS5 Gene COMPARTMENTS Subcellular localization image for RPS5 gene
Compartment Confidence
cytosol 5
nucleus 1

Gene Ontology (GO) - Cellular Components for RPS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005925 focal adhesion IDA 21423176
GO:0015935 small ribosomal subunit --
GO:0016020 membrane IDA 19946888
GO:0022627 cytosolic small ribosomal subunit IDA 15883184
genes like me logo Genes that share ontologies with RPS5: view

Pathways for RPS5 Gene

SuperPathways for RPS5 Gene

Superpath Contained pathways
1 Influenza Viral RNA Transcription and Replication
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 CFTR translational fidelity (class I mutations)
.54
4 Disease
5 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
genes like me logo Genes that share pathways with RPS5: view

Pathways by source for RPS5 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for RPS5 Gene
1 BioSystems pathway for RPS5 Gene

Gene Ontology (GO) - Biological Process for RPS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
GO:0006415 translational termination TAS --
genes like me logo Genes that share ontologies with RPS5: view

Transcripts for RPS5 Gene

Unigene Clusters for RPS5 Gene

Ribosomal protein S5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPS5 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
SP1: -
SP2: - -
SP3:
SP4:
SP5:

Relevant External Links for RPS5 Gene

GeneLoc Exon Structure for
RPS5
ECgene alternative splicing isoforms for
RPS5

Expression for RPS5 Gene

mRNA expression in normal human tissues for RPS5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS5 Gene

SOURCE GeneReport for Unigene cluster for RPS5 Gene Hs.378103

genes like me logo Genes that share expressions with RPS5: view

Orthologs for RPS5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPS5 36
  • 100 (n)
  • 100 (a)
RPS5 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RPS5 36
  • 89.38 (n)
  • 100 (a)
RPS5 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPS5 36
  • 89.71 (n)
  • 100 (a)
RPS5 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rps5 36
  • 90.52 (n)
  • 99.02 (a)
Rps5 16
Rps5 37
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPS5 37
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rps5 36
  • 90.03 (n)
  • 99.51 (a)
lizard
(Anolis carolinensis)
Reptilia RPS5 37
  • 99 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC64490 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rps5 36
  • 79.64 (n)
  • 94.58 (a)
Str.1676 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9001 36
zebrafish
(Danio rerio)
Actinopterygii -- 36
rps5 36
  • 84.41 (n)
  • 96.52 (a)
rps5 37
  • 96 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008329 36
  • 78.34 (n)
  • 89.34 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpS5a 36
  • 77.5 (n)
  • 87.68 (a)
RpS5a 37
  • 79 (a)
OneToMany
RpS5b 37
  • 76 (a)
OneToMany
CG7014 38
  • 86 (a)
RpS5 38
  • 88 (a)
worm
(Caenorhabditis elegans)
Secernentea rps-5 36
  • 73.6 (n)
  • 86.8 (a)
rps-5 37
  • 81 (a)
OneToOne
rps-5 38
  • 86 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR171W 36
  • 68.33 (n)
  • 71.14 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS5 36
  • 63.97 (n)
  • 71.21 (a)
RPS5 37
  • 63 (a)
OneToOne
RPS5 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D10659g 36
  • 65.95 (n)
  • 76.47 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons RPS5B 36
  • 68.59 (n)
  • 79.58 (a)
rice
(Oryza sativa)
Liliopsida Os11g0482000 36
  • 76.19 (n)
  • 82.54 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.3277 36
bread mold
(Neurospora crassa)
Ascomycetes NCU09475 36
  • 72.92 (n)
  • 79.69 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps502 36
  • 67.02 (n)
  • 74.21 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5398 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6156 37
  • 81 (a)
OneToOne
Species with no ortholog for RPS5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPS5 Gene

ENSEMBL:
Gene Tree for RPS5 (if available)
TreeFam:
Gene Tree for RPS5 (if available)

Paralogs for RPS5 Gene

genes like me logo Genes that share paralogs with RPS5: view

No data available for Paralogs for RPS5 Gene

Variants for RPS5 Gene

Sequence variations from dbSNP and Humsavar for RPS5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1802696 -- 58,393,414(+) GGACT(A/C)CACAC missense, reference
rs2289143 -- 58,393,348(-) GAGAA(A/G)GGGGA intron-variant
rs2289144 -- 58,393,303(-) CCTTT(C/T)CTCAT intron-variant
rs3764536 -- 58,385,345(-) TGAGG(A/G)GCATG upstream-variant-2KB
rs6510144 -- 58,389,301(+) agatc(A/G)ctctc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPS5 Gene

Variant ID Type Subtype PubMed ID
nsv833887 CNV Loss 17160897
nsv515731 CNV Gain+Loss 19592680
dgv4030n71 CNV Loss 21882294
nsv833888 CNV Loss 17160897
nsv817878 CNV Loss 17921354
essv17855 CNV CNV 17122850
dgv1136e1 CNV Complex 17122850

Relevant External Links for RPS5 Gene

HapMap Linkage Disequilibrium report
RPS5

Disorders for RPS5 Gene

(1) Novoseek inferred disease relationships for RPS5 Gene

Disease -log(P) Hits PubMed IDs
erythroleukemia 51.1 1
genes like me logo Genes that share disorders with RPS5: view

No data available for UniProtKB/Swiss-Prot for RPS5 Gene

Publications for RPS5 Gene

  1. Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs. (PMID: 7772601) Frigerio J.-M. … Iovanna J.L. (Biochim. Biophys. Acta 1995) 2 3 4
  2. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3 4
  3. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PMID: 8706699) Vladimirov S.N. … Otto A. (Eur. J. Biochem. 1996) 3 4
  4. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PMID: 11875025) Yoshihama M. … Kenmochi N. (Genome Res. 2002) 3 4
  5. Roles of the negatively charged N-terminal extension of Saccharomyces cerevisiae ribosomal protein S5 revealed by characterization of a yeast strain containing human ribosomal protein S5. (PMID: 17901157) Galkin O. … Komar A.A. (RNA 2007) 3 23

Products for RPS5 Gene

Sources for RPS5 Gene

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