Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RPS5 Gene

Aliases for RPS5 Gene

  • Ribosomal Protein S5 2 3 5
  • Small Ribosomal Subunit Protein US7 3 4
  • 40S Ribosomal Protein S5 2 3
  • S5 3

External Ids for RPS5 Gene

Previous GeneCards Identifiers for RPS5 Gene

  • GC19P059797
  • GC19P059352
  • GC19P063574
  • GC19P063590
  • GC19P059040
  • GC19P059053
  • GC19P055207
  • GC19P059076
  • GC19P059095
  • GC19P059106
  • GC19P059149
  • GC19P059205
  • GC19P059246
  • GC19P059295

Summaries for RPS5 Gene

Entrez Gene Summary for RPS5 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS5 Gene

RPS5 (Ribosomal Protein S5) is a Protein Coding gene. Diseases associated with RPS5 include Chromosome 2P16.1-P15 Deletion Syndrome and 2P16.1-P15 Deletion Syndrome. Among its related pathways are Viral mRNA Translation and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPS5 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS5 Gene

Genomics for RPS5 Gene

Regulatory Elements for RPS5 Gene

Enhancers for RPS5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G058384 1.4 ENCODE dbSUPER 20.8 +0.2 241 3.8 PKNOX1 CREB3L1 AGO1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 RPS5 ZNF132 TRIM28 ZNF446 MIR4754
GH19G058394 1.4 Ensembl ENCODE dbSUPER 20.3 +9.8 9750 3.4 PKNOX1 PTBP1 AGO1 SIN3A KLF17 GLIS2 SCRT2 RCOR1 KLF7 PAF1 RPS5 ZNF837 ZNF584 ZNF446 ENSG00000268912 ZNF814 ENSG00000268307 GC19M058391
GH19G058379 1.2 ENCODE 19.2 -5.3 -5315 2.9 CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 SLC30A9 ZNF143 ZNF263 SP3 NFYC ZSCAN18 ZNF584 LOC100128398 TRIM28 ZNF548 ZNF606 ZNF134 RPS5 ZNF132 ZNF549
GH19G057809 1.7 FANTOM5 ENCODE dbSUPER 9.7 -573.2 -573183 7.2 CREB3L1 MLX ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF134 ZNF264 TRIM28 ZNF17 ZNF417 ZNF256 ZNF543 ZNF805 ZNF606 ZNF773
GH19G058580 1.2 Ensembl ENCODE 10.1 +194.9 194865 1.5 PKNOX1 ATF1 CREB3L1 GTF3C2 ZNF766 ZNF143 KDM4B REST ZNF592 MEF2D TRIM28 ZNF587B ZNF324B ZNF134 ZNF587 CENPBD1P1 ZBTB45 UBE2M CHMP2A ZNF417
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPS5 on UCSC Golden Path with GeneCards custom track

Promoters for RPS5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000111872 700 1801 PKNOX1 MLX CREB3L1 AGO1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for RPS5 Gene

Chromosome:
19
Start:
58,386,400 bp from pter
End:
58,394,806 bp from pter
Size:
8,407 bases
Orientation:
Plus strand

Genomic View for RPS5 Gene

Genes around RPS5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS5 Gene

Proteins for RPS5 Gene

  • Protein details for RPS5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46782-RS5_HUMAN
    Recommended name:
    40S ribosomal protein S5
    Protein Accession:
    P46782
    Secondary Accessions:
    • B2R4T2
    • Q96BN0

    Protein attributes for RPS5 Gene

    Size:
    204 amino acids
    Molecular mass:
    22876 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS5 Gene

neXtProt entry for RPS5 Gene

Post-translational modifications for RPS5 Gene

  • Ubiquitination at isoforms=18, Lys22, Lys47, isoforms=63, isoforms=167, and Lys182
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS5 Gene

No data available for DME Specific Peptides for RPS5 Gene

Domains & Families for RPS5 Gene

Gene Families for RPS5 Gene

Suggested Antigen Peptide Sequences for RPS5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P46782

UniProtKB/Swiss-Prot:

RS5_HUMAN :
  • Belongs to the universal ribosomal protein uS7 family.
Family:
  • Belongs to the universal ribosomal protein uS7 family.
genes like me logo Genes that share domains with RPS5: view

Function for RPS5 Gene

Molecular function for RPS5 Gene

GENATLAS Biochemistry:
40S ribosomal protein S5

Gene Ontology (GO) - Molecular Function for RPS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding NAS 7772601
GO:0003729 mRNA binding IDA 18464793
GO:0003735 structural constituent of ribosome IDA 15883184
GO:0005515 protein binding IPI 24965446
genes like me logo Genes that share ontologies with RPS5: view
genes like me logo Genes that share phenotypes with RPS5: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RPS5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS5 Gene

Localization for RPS5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS5 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
GO:0005925 focal adhesion IDA 21423176
GO:0015935 small ribosomal subunit IEA --
genes like me logo Genes that share ontologies with RPS5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS5 Gene

Pathways & Interactions for RPS5 Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
.56
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing in the nucleus and cytosol
5 HIV Life Cycle
.45
genes like me logo Genes that share pathways with RPS5: view

Gene Ontology (GO) - Biological Process for RPS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation NAS 7772601
GO:0006413 translational initiation TAS --
GO:0006450 regulation of translational fidelity IGI 17901157
genes like me logo Genes that share ontologies with RPS5: view

No data available for SIGNOR curated interactions for RPS5 Gene

Drugs & Compounds for RPS5 Gene

No Compound Related Data Available

Transcripts for RPS5 Gene

Unigene Clusters for RPS5 Gene

Ribosomal protein S5:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RPS5

Alternative Splicing Database (ASD) splice patterns (SP) for RPS5 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
SP1: -
SP2: - -
SP3:
SP4:
SP5:

Relevant External Links for RPS5 Gene

GeneLoc Exon Structure for
RPS5
ECgene alternative splicing isoforms for
RPS5

Expression for RPS5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPS5 Gene

Protein differential expression in normal tissues from HIPED for RPS5 Gene

This gene is overexpressed in Tlymphocyte (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPS5 Gene



Protein tissue co-expression partners for RPS5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS5 Gene:

RPS5

SOURCE GeneReport for Unigene cluster for RPS5 Gene:

Hs.378103

Evidence on tissue expression from TISSUES for RPS5 Gene

  • Intestine(4.9)
  • Liver(4.8)
  • Nervous system(4.8)
  • Lung(4.7)
  • Bone(4.6)
  • Skin(4.6)
  • Eye(4.5)
  • Pancreas(4.4)
  • Muscle(3.8)
  • Stomach(3.5)
  • Heart(3.3)
  • Kidney(3.2)
  • Blood(2.9)
  • Bone marrow(2.6)
  • Lymph node(2.6)
  • Thyroid gland(2.5)
  • Spleen(2.4)
  • Adrenal gland(2.3)
  • Gall bladder(2.3)
genes like me logo Genes that share expression patterns with RPS5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS5 Gene

Orthologs for RPS5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPS5 34 35
  • 100 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RPS5 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rps5 34 16 35
  • 90.52 (n)
rat
(Rattus norvegicus)
Mammalia Rps5 34
  • 90.03 (n)
dog
(Canis familiaris)
Mammalia RPS5 34 35
  • 89.71 (n)
cow
(Bos Taurus)
Mammalia RPS5 34 35
  • 89.38 (n)
lizard
(Anolis carolinensis)
Reptilia RPS5 35
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rps5 34
  • 79.64 (n)
Str.1676 34
African clawed frog
(Xenopus laevis)
Amphibia MGC64490 34
zebrafish
(Danio rerio)
Actinopterygii rps5 34 35
  • 84.41 (n)
-- 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9001 34
fruit fly
(Drosophila melanogaster)
Insecta RpS5 36
  • 88 (a)
CG7014 36
  • 86 (a)
RpS5a 34 35
  • 77.5 (n)
RpS5b 35
  • 76 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008329 34
  • 78.34 (n)
worm
(Caenorhabditis elegans)
Secernentea rps-5 36 34 35
  • 73.6 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR171W 34
  • 68.33 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D10659g 34
  • 65.95 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS5 34 35 37
  • 63.97 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons RPS5B 34
  • 68.59 (n)
rice
(Oryza sativa)
Liliopsida Os11g0482000 34
  • 76.19 (n)
wheat
(Triticum aestivum)
Liliopsida Ta.3277 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6156 35
  • 81 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU09475 34
  • 72.92 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps502 34
  • 67.02 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5398 34
Species where no ortholog for RPS5 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPS5 Gene

ENSEMBL:
Gene Tree for RPS5 (if available)
TreeFam:
Gene Tree for RPS5 (if available)

Paralogs for RPS5 Gene

No data available for Paralogs for RPS5 Gene

Variants for RPS5 Gene

Sequence variations from dbSNP and Humsavar for RPS5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000196076 -- 58,393,814(+) AGGTG(C/T)CTTTA intron-variant, upstream-variant-2KB
rs1000405423 -- 58,386,928(+) AGGTG(A/G)GATTT upstream-variant-2KB
rs1000458424 -- 58,391,341(+) GCAGG(A/G)GAATC intron-variant
rs1000894230 -- 58,387,315(+) GTGAC(A/C/G)GAGAC upstream-variant-2KB, utr-variant-5-prime
rs1000945998 -- 58,387,484(+) AGTTA(C/T)TCTTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPS5 Gene

Variant ID Type Subtype PubMed ID
esv2758775 CNV loss 17122850
nsv515731 CNV gain+loss 19592680
nsv817878 CNV loss 17921354
nsv833887 CNV loss 17160897
nsv833888 CNV loss 17160897
nsv961256 CNV duplication 23825009

Variation tolerance for RPS5 Gene

Residual Variation Intolerance Score: 32.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.25; 5.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPS5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS5 Gene

Disorders for RPS5 Gene

MalaCards: The human disease database

(3) MalaCards diseases for RPS5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
chromosome 2p16.1-p15 deletion syndrome
  • 2p15-p16.1 microdeletion syndrome
2p16.1-p15 deletion syndrome
retinitis pigmentosa 14
  • rp14
- elite association - COSMIC cancer census association via MalaCards
Search RPS5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RPS5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPS5
genes like me logo Genes that share disorders with RPS5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS5 Gene

Publications for RPS5 Gene

  1. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3 4 64
  2. Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs. (PMID: 7772601) Frigerio J.-M. … Iovanna J.L. (Biochim. Biophys. Acta 1995) 2 3 4 64
  3. [Mutual effect of human ribosomal proteins S5 and S16 on their binding with 18S rRNA fragment 1203-1236/1521-1698]. (PMID: 19807034) Ian'shina D.D. … Karpova G.G. (Mol. Biol. (Mosk.) 2009) 3 22 64
  4. Roles of the negatively charged N-terminal extension of Saccharomyces cerevisiae ribosomal protein S5 revealed by characterization of a yeast strain containing human ribosomal protein S5. (PMID: 17901157) Galkin O. … Komar A.A. (RNA 2007) 3 22 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for RPS5 Gene

Sources for RPS5 Gene

Content
Loading form....