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Aliases for RPS5 Gene

Aliases for RPS5 Gene

  • Ribosomal Protein S5 2 3 5
  • 40S Ribosomal Protein S5 2 3
  • S5 3

External Ids for RPS5 Gene

Previous GeneCards Identifiers for RPS5 Gene

  • GC19P059797
  • GC19P059352
  • GC19P063574
  • GC19P063590
  • GC19P059040
  • GC19P059053
  • GC19P055207
  • GC19P059076
  • GC19P059095
  • GC19P059106
  • GC19P059149
  • GC19P059205
  • GC19P059246
  • GC19P059295

Summaries for RPS5 Gene

Entrez Gene Summary for RPS5 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS5 Gene

RPS5 (Ribosomal Protein S5) is a Protein Coding gene. Diseases associated with RPS5 include Giant Axonal Neuropathy. Among its related pathways are Viral mRNA Translation and Transport to the Golgi and subsequent modification. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPS5 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS5 Gene

Genomics for RPS5 Gene

Regulatory Elements for RPS5 Gene

Enhancers for RPS5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around RPS5 on UCSC Golden Path with GeneCards custom track

Promoters for RPS5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for RPS5 Gene

58,386,400 bp from pter
58,394,806 bp from pter
8,407 bases
Plus strand

Genomic View for RPS5 Gene

Genes around RPS5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS5 Gene

Proteins for RPS5 Gene

  • Protein details for RPS5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    40S ribosomal protein S5
    Protein Accession:
    Secondary Accessions:
    • B2R4T2
    • Q96BN0

    Protein attributes for RPS5 Gene

    204 amino acids
    Molecular mass:
    22876 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS5 Gene

neXtProt entry for RPS5 Gene

Post-translational modifications for RPS5 Gene

  • Ubiquitination at Lys 18, Lys 22, Lys 47, Lys 63, Lys 167, and Lys 182
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS5 Gene

No data available for DME Specific Peptides for RPS5 Gene

Domains & Families for RPS5 Gene

Gene Families for RPS5 Gene

Protein Domains for RPS5 Gene

Suggested Antigen Peptide Sequences for RPS5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein S7P family.
  • Belongs to the ribosomal protein S7P family.
genes like me logo Genes that share domains with RPS5: view

Function for RPS5 Gene

Molecular function for RPS5 Gene

GENATLAS Biochemistry:
40S ribosomal protein S5

Gene Ontology (GO) - Molecular Function for RPS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding NAS 7772601
GO:0003729 mRNA binding IDA 18464793
GO:0003735 structural constituent of ribosome IDA 15883184
GO:0005515 protein binding IPI 24965446
GO:0019843 rRNA binding IBA --
genes like me logo Genes that share ontologies with RPS5: view
genes like me logo Genes that share phenotypes with RPS5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS5 Gene

Localization for RPS5 Gene

Subcellular locations from

Jensen Localization Image for RPS5 Gene COMPARTMENTS Subcellular localization image for RPS5 gene
Compartment Confidence
cytosol 5
extracellular 5
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RPS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0005925 focal adhesion IDA 21423176
GO:0016020 membrane IDA 19946888
GO:0022627 cytosolic small ribosomal subunit IDA 8706699
genes like me logo Genes that share ontologies with RPS5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS5 Gene

Pathways & Interactions for RPS5 Gene

SuperPathways for RPS5 Gene

Superpath Contained pathways
1 Viral mRNA Translation
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 Infectious disease
5 rRNA processing
genes like me logo Genes that share pathways with RPS5: view

Gene Ontology (GO) - Biological Process for RPS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000028 ribosomal small subunit assembly IBA --
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation NAS 7772601
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPS5: view

No data available for SIGNOR curated interactions for RPS5 Gene

Drugs & Compounds for RPS5 Gene

No Compound Related Data Available

Transcripts for RPS5 Gene

Unigene Clusters for RPS5 Gene

Ribosomal protein S5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS5 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
SP1: -
SP2: - -

Relevant External Links for RPS5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS5 Gene

mRNA expression in normal human tissues for RPS5 Gene

Protein differential expression in normal tissues from HIPED for RPS5 Gene

This gene is overexpressed in Tlymphocyte (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPS5 Gene

Protein tissue co-expression partners for RPS5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS5 Gene:


SOURCE GeneReport for Unigene cluster for RPS5 Gene:

genes like me logo Genes that share expression patterns with RPS5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS5 Gene

Orthologs for RPS5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPS5 34
  • 89.38 (n)
  • 100 (a)
RPS5 35
  • 100 (a)
(Canis familiaris)
Mammalia RPS5 34
  • 89.71 (n)
  • 100 (a)
RPS5 35
  • 100 (a)
(Mus musculus)
Mammalia Rps5 34
  • 90.52 (n)
  • 99.02 (a)
Rps5 16
Rps5 35
  • 99 (a)
(Pan troglodytes)
Mammalia RPS5 34
  • 100 (n)
  • 100 (a)
RPS5 35
  • 100 (a)
(Rattus norvegicus)
Mammalia Rps5 34
  • 90.03 (n)
  • 99.51 (a)
(Ornithorhynchus anatinus)
Mammalia RPS5 35
  • 100 (a)
(Anolis carolinensis)
Reptilia RPS5 35
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rps5 34
  • 79.64 (n)
  • 94.58 (a)
Str.1676 34
African clawed frog
(Xenopus laevis)
Amphibia MGC64490 34
(Danio rerio)
Actinopterygii -- 34
rps5 34
  • 84.41 (n)
  • 96.52 (a)
rps5 35
  • 96 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9001 34
fruit fly
(Drosophila melanogaster)
Insecta CG7014 36
  • 86 (a)
RpS5 36
  • 88 (a)
RpS5a 34
  • 77.5 (n)
  • 87.68 (a)
RpS5a 35
  • 79 (a)
RpS5b 35
  • 76 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008329 34
  • 78.34 (n)
  • 89.34 (a)
(Caenorhabditis elegans)
Secernentea rps-5 36
  • 86 (a)
rps-5 34
  • 73.6 (n)
  • 86.8 (a)
rps-5 35
  • 81 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR171W 34
  • 68.33 (n)
  • 71.14 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D10659g 34
  • 65.95 (n)
  • 76.47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS5 34
  • 63.97 (n)
  • 71.21 (a)
RPS5 35
  • 63 (a)
RPS5 37
thale cress
(Arabidopsis thaliana)
eudicotyledons RPS5B 34
  • 68.59 (n)
  • 79.58 (a)
(Oryza sativa)
Liliopsida Os11g0482000 34
  • 76.19 (n)
  • 82.54 (a)
(Triticum aestivum)
Liliopsida Ta.3277 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5398 34
bread mold
(Neurospora crassa)
Ascomycetes NCU09475 34
  • 72.92 (n)
  • 79.69 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps502 34
  • 67.02 (n)
  • 74.21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6156 35
  • 81 (a)
Species where no ortholog for RPS5 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPS5 Gene

Gene Tree for RPS5 (if available)
Gene Tree for RPS5 (if available)

Paralogs for RPS5 Gene

genes like me logo Genes that share paralogs with RPS5: view

No data available for Paralogs for RPS5 Gene

Variants for RPS5 Gene

Sequence variations from dbSNP and Humsavar for RPS5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs3764536 -- 58,385,345(-) TGAGG(A/G)GCATG upstream-variant-2KB
rs11545062 -- 58,393,050(+) CGCTT(C/T)CGCAA reference, synonymous-codon
rs11545063 -- 58,393,443(+) CTGTG(A/C)GACGA reference, synonymous-codon
rs6721 -- 58,393,029(+) GCAGG(A/G)CGGTA reference, synonymous-codon
rs34313816 -- 58,393,526(+) CACAG(-/C)CCACG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPS5 Gene

Variant ID Type Subtype PubMed ID
esv2758775 CNV loss 17122850
nsv515731 CNV gain+loss 19592680
nsv817878 CNV loss 17921354
nsv833887 CNV loss 17160897
nsv833888 CNV loss 17160897
nsv961256 CNV duplication 23825009

Variation tolerance for RPS5 Gene

Residual Variation Intolerance Score: 32.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.25; 5.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS5 Gene

Disorders for RPS5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPS5 Gene - From: GeneCards

Disorder Aliases PubMed IDs
giant axonal neuropathy
  • gan1
- elite association - COSMIC cancer census association via MalaCards
Search RPS5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RPS5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RPS5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS5 Gene

Publications for RPS5 Gene

  1. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3 4 65
  2. Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs. (PMID: 7772601) Frigerio J.-M. … Iovanna J.L. (Biochim. Biophys. Acta 1995) 2 3 4 65
  3. [Mutual effect of human ribosomal proteins S5 and S16 on their binding with 18S rRNA fragment 1203-1236/1521-1698]. (PMID: 19807034) Ian'shina D.D. … Karpova G.G. (Mol. Biol. (Mosk.) 2009) 3 22 65
  4. Roles of the negatively charged N-terminal extension of Saccharomyces cerevisiae ribosomal protein S5 revealed by characterization of a yeast strain containing human ribosomal protein S5. (PMID: 17901157) Galkin O. … Komar A.A. (RNA 2007) 3 22 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65

Products for RPS5 Gene

Sources for RPS5 Gene

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