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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RPS4Y2 Gene

protein-coding GIFtS: 43
GCID: GC0YP022917

ribosomal protein S4, Y-linked 2

(Previous names: ribosomal protein S4, Y-linked 2 pseudogene )
(Previous symbol: RPS4Y2P)

Explore 4 diseases affiliated with
RPS4Y2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ribosomal Protein S4, Y-Linked 2¹ ²
RPS4Y2P¹ ² ³
Ribosomal Protein S4, Y-Linked 2 Pseudogene¹ ²
40S Ribosomal Protein S4, Y²
40S Ribosomal Protein S4, Y Isoform 2²

External Ids:	HGNC: 18501¹	Entrez Gene: 140032²	Ensembl: ENSG00000157828⁷	OMIM: 400030⁵	UniProtKB: Q8TD47³

Export aliases for RPS4Y2 gene to outside databases

Previous GC identifers: GC0YP022073 GC0YP021763 GC0YP021256 GC0YP021327 GC0YP016504

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RPS4Y2:

The protein encoded by this gene is a ribosomal protein that is highly similar to RPS4Y1. This gene is located in the

male-specific region of the Y chromosome. (provided by RefSeq, Aug 2012)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000024.9 NT_011875.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RPS4Y2 gene promoter:
Elk-1 HOXA3 Pax-6 Nkx2-5 RORalpha2 GATA-1 FOXL1 RORalpha1 Ik-1
Other transcription factors

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS4Y2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Yq11.223 Ensembl cytogenetic band: Yq11.223 HGNC cytogenetic band: Yq11.223

RPS4Y2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS4Y2 gene location

GeneLoc information about chromosome Y GeneLoc Exon Structure

GeneLoc location for GC0YP022917: view genomic region (about GC identifiers)

Start:	22,917,954 bp from pter	End:	22,942,918 bp from pter
Size:	24,965 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RS4Y2_HUMAN, Q8TD47 (See protein sequence)

Recommended Name: 40S ribosomal protein S4, Y isoform 2

Size: 263 amino acids; 29295 Da

Secondary accessions: A6NIR6

Explore the universe of human proteins at neXtProt for RPS4Y2: NX_Q8TD47

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8TD47

RPS4Y2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001034656.1

ENSEMBL proteins:

ENSP00000288666

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005840	ribosome	IEA	--

RPS4Y2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RPS4Y2 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR013845 Ribosomal_S4e_central

IPR002942 S4_RNA-bd

IPR013843 Ribosomal_S4e_N

IPR000876 Ribosomal_S4e

IPR018199 Ribosomal_S4e_N_CS

Graphical View of Domain Structure for InterPro Entry Q8TD47

ProtoNet protein and cluster: Q8TD47

3 Blocks protein families:

IPB000876 Ribosomal protein S4E

IPB002942 RNA-binding S4

IPB006646 KOW (Kyprides

UniProtKB/Swiss-Prot: RS4Y2_HUMAN, Q8TD47

Similarity: Belongs to the ribosomal protein S4e family

Similarity: Contains 1 S4 RNA-binding domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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In Situ Assay
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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003735	structural constituent of ribosome	IEA	--
GO:0019843	rRNA binding	IEA	--

RPS4Y2 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Synthesis of PB1-F2

CFTR translational fidelity (class I mutations)

0.83

Pathway sources
See GeneCards unified pathways
Show all pathways

1 GeneGo (Thomson Reuters) Pathway for RPS4Y2

CFTR translational fidelity (class I mutations)

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RPS4Y2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/99 Interacting proteins for RPS4Y2 (ENSP00000288666⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 99)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RPS13	ENSP00000228140⁴	STRING: ENSP00000228140
RPS5	ENSP00000196551⁴	STRING: ENSP00000196551
RPS3	ENSP00000278572⁴	STRING: ENSP00000278572
RPS9	ENSP00000302896⁴	STRING: ENSP00000302896
RPS6	ENSP00000369757⁴	STRING: ENSP00000369757

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006412	translation	IEA	--

RPS4Y2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Browse Tocris compounds for RPS4Y2
Search CenterWatch for drugs/clinical trials and news about RPS4Y2 / RS4Y2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for RPS4Y2 gene:

NM_001039567.2

Unigene Cluster for RPS4Y2:

Ribosomal protein S4, Y-linked 2

Hs.367761

Unigene Representative Sequence: NM_001039567

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000288666(uc011nbb.2)

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Additional cDNA sequence: AF497481.2

1 DOTS entry:

DT.120653212

2 AceView cDNA sequences:

NM_138963 AF497481

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RPS4Y2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

RPS4Y2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Human umbilical vein endothelial cells (HUVEC) (Primary Cell)

Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RPS4Y2 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.367761

SABiosciences Custom PCR Arrays for RPS4Y2

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS4Y2 gene from 7/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RS4_CHICK⁶	40S ribosomal protein S4	90(a)	1 → many	4(1862580-1865080)
lizard (Anolis carolinensis)	Reptilia	--	--	93(a)	1 → many	GL343686.1(237406-240651)
zebrafish (Danio rerio)	Actinopterygii	rps4x⁶	ribosomal protein S4, X-linked	87(a)	1 → many	7(53088995-53094879)
fruit fly (Drosophila melanogaster)	Insecta	RpS4³	protein biosynthesis structural constituent of more	72(a)		69F6 --
worm (Caenorhabditis elegans)	Secernentea	Y43B11AR.4³	--	61(a)		IV(7083923-7084849) --
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G17360⁶ AT5G58420⁶ (see all 3)	40S ribosomal protein S4-3 (see all 3)	65(a) 65(a) (see all 3)	many ↔ many many ↔ many (see all 3)	2(7546480-7548313) 5(23619506-23621094)
rice (Oryza sativa)	Liliopsida	-- -- (see all 3)	40S ribosomal protein S4, putative, expressed (see all 3)	66(a) 65(a) (see all 3)	many ↔ many many ↔ many (see all 3)	1(14512295-14514420) 5(17632739-17635426)

ENSEMBL Gene Tree for RPS4Y2 (if available)
TreeFam Gene Tree for RPS4Y2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RPS4Y2 gene

RPS4XP21² RPS4Y1² RPS4X²

3 SIMAP similar genes for RPS4Y2 using alignment to 1 protein entry: RS4Y2_HUMAN:

RPS4Y1 RPS4X RPS4XP21

RPS4Y2 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for RPS4Y2
PGOHUM00000249330

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr Y pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs35474563^1,2	C	--	22917995(+)	`CACCGC/TAGATT`	1	--	ut5¹		2		MN NA	43
rs16980548^1,2	C,F,H	--	22918577(+)	`ATTACC/TCGTTA`	1	--	int¹		11		NA MN NS EA WA CSA	327
rs13305747^1,2	C	--	22919819(+)	`CAGACA/CTGAGG`	1	--	int¹		0	--	--	--	--
rs13305800^1,2	C	--	22919840(+)	`ATGTGC/ATAAAT`	1	--	int¹		1		NA	2
rs34581739^1,2	C,F	--	22921768(+)	`CCATCG/AACAGG`	2	/S	syn¹		2		MN NA	48
rs34740450^1,2	C,F	--	22922129(+)	`AAGGGG/ATTGGT`	1	--	int¹		2		MN NA	48
rs13304464^1,2	C	--	22924348(+)	`TGTTGT/CGTCTA`	1	--	int¹		1		NA	2
rs13305220^1,2	C,F	--	22927023(+)	`TGGGGC/TCAGAA`	1	--	int¹		2		NA	4
rs34123756^1,2	C	--	22928067(+)	`GCTTTC/TGCTGG`	1	--	int¹		0	--	--	--	--
rs34194308^1,2	C,F,H	--	22928344(+)	`TAAATC/GTAGCA`	1	--	int¹		6		NS EA NA	215

HapMap Linkage Disequilibrium report for RPS4Y2 (22917954 - 22942918 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RPS4Y2
1 CNV: 31588

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RPS4Y2 for disorders           About GeneDecksing

OMIM gene information: 400030    OMIM disorders: --

4 diseases for RPS4Y2:    About MalaCards

azoospermia malaria y chromosome infertility infertility

1 disease from the University of Copenhagen DISEASES database for RPS4Y2:

Azoospermia

Export disorders for RPS4Y2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RPS4Y2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RPS4Y2)

Utopia: connect your pdf to the dynamic
world of online information

The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PubMed id 12815422)^{1, 2, 3} Skaletsky H.... Page D.C. (2003)
Primer-BLAST: a tool to design target-specific primers for polymerase chain reaction. (PubMed id 22708584)¹ Ye J....Madden T.L. (2012)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
The human RPS4 paralogue on Yq11.223 encodes a struct urally conserved ribosomal protein and is preferentially expressed during sperm atogenesis. (PubMed id 20459660)¹ Lopes A.M....Affara N.A. (2010)
Y Chromosome Infertility (PubMed id 20301513)¹ Disteche C.M. (1993)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 140032	HGNC: 18501	AceView: RPS4Y2	Ensembl:ENSG00000157828	euGenes: HUgn140032
ECgene: RPS4Y2	H-InvDB: RPS4Y2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RPS4Y2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RPS4Y2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RPS4Y2 gene:
Search GeneIP for patents involving RPS4Y2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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	GenScript Custom Purified and Recombinant Proteins Services for RPS4Y2		GenScript cDNA clones with any tag delivered in your preferred vector for RPS4Y2
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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes RPS4Y2 gene at Home site.

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RPS4Y2 Gene

ribosomal protein S4, Y-linked 2

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RPS4Y2 Gene

ribosomal protein S4, Y-linked 2

Aliasesfor RPS4Y2 gene

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