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Aliases for RPS4Y2 Gene

Aliases for RPS4Y2 Gene

  • Ribosomal Protein S4, Y-Linked 2 2 3
  • Ribosomal Protein S4, Y-Linked 2 Pseudogene 2 3
  • RPS4Y2P 3 4
  • 40S Ribosomal Protein S4, Y Isoform 2 3
  • 40S Ribosomal Protein S4, Y 3

External Ids for RPS4Y2 Gene

Previous HGNC Symbols for RPS4Y2 Gene

  • RPS4Y2P

Previous GeneCards Identifiers for RPS4Y2 Gene

  • GC0YP022073
  • GC0YP021763
  • GC0YP021256
  • GC0YP021327
  • GC0YP022917
  • GC0YP016504

Summaries for RPS4Y2 Gene

Entrez Gene Summary for RPS4Y2 Gene

  • The protein encoded by this gene is a ribosomal protein that is highly similar to RPS4Y1. This gene is located in the male-specific region of the Y chromosome. [provided by RefSeq, Aug 2012]

GeneCards Summary for RPS4Y2 Gene

RPS4Y2 (Ribosomal Protein S4, Y-Linked 2) is a Protein Coding gene. Diseases associated with RPS4Y2 include y chromosome infertility. Among its related pathways are CFTR translational fidelity (class I mutations). GO annotations related to this gene include structural constituent of ribosome and rRNA binding.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS4Y2 Gene

Genomics for RPS4Y2 Gene

Regulatory Elements for RPS4Y2 Gene

Genomic Location for RPS4Y2 Gene

Start:
20,756,068 bp from pter
End:
20,781,032 bp from pter
Size:
24,965 bases
Orientation:
Plus strand

Genomic View for RPS4Y2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPS4Y2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS4Y2 Gene

Proteins for RPS4Y2 Gene

  • Protein details for RPS4Y2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TD47-RS4Y2_HUMAN
    Recommended name:
    40S ribosomal protein S4, Y isoform 2
    Protein Accession:
    Q8TD47
    Secondary Accessions:
    • A6NIR6

    Protein attributes for RPS4Y2 Gene

    Size:
    263 amino acids
    Molecular mass:
    29295 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RPS4Y2 Gene

Proteomics data for RPS4Y2 Gene at MOPED

Post-translational modifications for RPS4Y2 Gene

  • Ubiquitination at Lys16, Lys22, Lys37, Lys53, Lys62, and Lys233
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS4Y2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPS4Y2 Gene

Domains for RPS4Y2 Gene

Gene Families for RPS4Y2 Gene

HGNC:
  • RPS :S ribosomal proteins

Suggested Antigen Peptide Sequences for RPS4Y2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TD47

UniProtKB/Swiss-Prot:

RS4Y2_HUMAN :
  • Q8TD47
Domain:
  • Contains 1 S4 RNA-binding domain.
Family:
  • Belongs to the ribosomal protein S4e family.
genes like me logo Genes that share domains with RPS4Y2: view

Function for RPS4Y2 Gene

Gene Ontology (GO) - Molecular Function for RPS4Y2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003723 RNA binding --
GO:0003735 structural constituent of ribosome IEA --
GO:0019843 rRNA binding IEA --
genes like me logo Genes that share ontologies with RPS4Y2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPS4Y2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RPS4Y2 Gene

Localization for RPS4Y2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS4Y2 Gene COMPARTMENTS Subcellular localization image for RPS4Y2 gene
Compartment Confidence
cytosol 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for RPS4Y2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005622 intracellular --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with RPS4Y2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS4Y2 Gene

Pathways for RPS4Y2 Gene

genes like me logo Genes that share pathways with RPS4Y2: view

Pathways by source for RPS4Y2 Gene

1 GeneGo (Thomson Reuters) pathway for RPS4Y2 Gene

Interacting Proteins for RPS4Y2 Gene

Gene Ontology (GO) - Biological Process for RPS4Y2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with RPS4Y2: view

Transcripts for RPS4Y2 Gene

mRNA/cDNA for RPS4Y2 Gene

(2) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPS4Y2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS4Y2 Gene

No ASD Table

Relevant External Links for RPS4Y2 Gene

GeneLoc Exon Structure for
RPS4Y2
ECgene alternative splicing isoforms for
RPS4Y2

Expression for RPS4Y2 Gene

mRNA expression in normal human tissues for RPS4Y2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RPS4Y2 Gene

This gene is overexpressed in Testis (22.4) and Prostate (17.2).

Protein differential expression in normal tissues for RPS4Y2 Gene

This gene is overexpressed in Heart (39.7) and Brain (29.3).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for RPS4Y2 Gene

SOURCE GeneReport for Unigene cluster for RPS4Y2 Gene Hs.367761

genes like me logo Genes that share expressions with RPS4Y2: view

Expression partners for RPS4Y2 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RPS4Y2 Gene

Orthologs for RPS4Y2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RPS4Y2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPS4Y1 35
  • 79.72 (n)
  • 90.87 (a)
dog
(Canis familiaris)
Mammalia RPS4X 35
  • 80.86 (n)
  • 91.63 (a)
chimpanzee
(Pan troglodytes)
Mammalia RPS4Y2 35
  • 98.99 (n)
  • 97.34 (a)
rat
(Rattus norvegicus)
Mammalia Rps4y2 35
  • 73.82 (n)
  • 86.59 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpS4 37
  • 72 (a)
worm
(Caenorhabditis elegans)
Secernentea Y43B11AR.4 37
  • 61 (a)
Species with no ortholog for RPS4Y2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for RPS4Y2 Gene

ENSEMBL:
Gene Tree for RPS4Y2 (if available)
TreeFam:
Gene Tree for RPS4Y2 (if available)

Paralogs for RPS4Y2 Gene

Selected SIMAP similar genes for RPS4Y2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RPS4Y2: view

No data available for Paralogs for RPS4Y2 Gene

Variants for RPS4Y2 Gene

Sequence variations from dbSNP and Humsavar for RPS4Y2 Gene

SNP ID Clin Chr 0Y pos Sequence Context AA Info Type MAF
rs9786516 -- 20,772,223(+) gtcat(A/G)gaaat intron-variant
rs13303733 -- 20,762,643(+) cgctg(A/C)aacct intron-variant
rs13303931 -- 20,762,642(+) tcgct(A/G)caacc intron-variant
rs13303993 -- 20,766,813(+) CCTCA(A/G)CAGCT intron-variant
rs13304464 -- 20,762,462(+) TGTTG(C/T)GTCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPS4Y2 Gene

Variant ID Type Subtype PubMed ID
nsv10025 CNV Gain 18304495

Relevant External Links for RPS4Y2 Gene

HapMap Linkage Disequilibrium report
RPS4Y2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS4Y2 Gene

Disorders for RPS4Y2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for RPS4Y2 Gene in MalaCards »

(1) Diseases for RPS4Y2 Gene including...

genes like me logo Genes that share disorders with RPS4Y2: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for RPS4Y2 Gene

Publications for RPS4Y2 Gene

  1. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H. … Page D.C. (Nature 2003) 2 3 4
  2. Y Chromosome Infertility (PMID: 20301513) Pagon R.A. … Stephens K. ( 1993) 3
  3. The human RPS4 paralogue on Yq11.223 encodes a structurally conserved ribosomal protein and is preferentially expressed during spermatogenesis. (PMID: 20459660) Lopes A.M. … Affara N.A. (BMC Mol. Biol. 2010) 3
  4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3

Products for RPS4Y2 Gene

Sources for RPS4Y2 Gene

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