Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RPS4Y2 Gene

protein-coding GIFtS: 42
GCID: GC0YP022917

Ribosomal Protein S4, Y-Linked 2

(Previous names: ribosomal protein S4, Y-linked 2 pseudogene)
(Previous symbol: RPS4Y2P)

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Ribosomal Protein S4, Y-Linked 2¹ ²
RPS4Y2P¹ ² ³
Ribosomal Protein S4, Y-Linked 2 Pseudogene¹ ²
40S Ribosomal Protein S4, Y²
40S Ribosomal Protein S4, Y Isoform 2²

External Ids:	HGNC: 18501¹	Entrez Gene: 140032²	Ensembl: ENSG00000157828⁷	OMIM: 400030⁵	UniProtKB: Q8TD47³

Export aliases for RPS4Y2 gene to outside databases

Previous GC identifers: GC0YP022073 GC0YP021763 GC0YP021256 GC0YP021327 GC0YP016504

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RPS4Y2 Gene:

The protein encoded by this gene is a ribosomal protein that is highly similar to RPS4Y1. This gene is located in

the male-specific region of the Y chromosome. (provided by RefSeq, Aug 2012)

GeneCards Summary for RPS4Y2 Gene:

RPS4Y2 (ribosomal protein S4, Y-linked 2) is a protein-coding gene. Diseases associated with RPS4Y2 include y chromosome infertility, and azoospermia, and among its related super-pathways are Viral mRNA Translation. GO annotations related to this gene include structural constituent of ribosome and rRNA binding. An important paralog of this gene is RPS4Y1.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000024.9 NT_011875.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RPS4Y2 gene promoter:
Elk-1 HOXA3 Pax-6 Nkx2-5 RORalpha2 GATA-1 FOXL1 RORalpha1 Ik-1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for RPS4Y2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS4Y2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Yq11.223 Ensembl cytogenetic band: Yq11.223 HGNC cytogenetic band: Yq11.223

RPS4Y2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS4Y2 gene location

GeneLoc information about chromosome Y GeneLoc Exon Structure

GeneLoc location for GC0YP022917: view genomic region (about GC identifiers)

Start:	22,917,954 bp from pter	End:	22,942,918 bp from pter
Size:	24,965 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RS4Y2_HUMAN, Q8TD47 (See protein sequence)

Recommended Name: 40S ribosomal protein S4, Y isoform 2

Size: 263 amino acids; 29295 Da

Secondary accessions: A6NIR6

Explore the universe of human proteins at neXtProt for RPS4Y2: NX_Q8TD47

Explore proteomics data for RPS4Y2 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q8TD47

RPS4Y2 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_001034656.1

ENSEMBL proteins:

ENSP00000288666

Human Recombinant Protein Products for RPS4Y2:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for RPS4Y2 OriGene Custom MassSpec OriGene Custom Protein Services for RPS4Y2
	GenScript Custom Purified and Recombinant Proteins Services for RPS4Y2
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for RPS4Y2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005840	ribosome	IEA	--

RPS4Y2 for ontologies About GeneDecksing

RPS4Y2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for RPS4Y2
	GenScript Custom Superior Antibodies Services for RPS4Y2
	Abcam antibodies for RPS4Y2
	Cloud-Clone Corp. Antibodies for RPS4Y2
	Search ThermoFisher Antibodies for RPS4Y2
	LSBio Antibodies in human, mouse, rat for RPS4Y2

Assay Products for RPS4Y2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for RPS4Y2
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RPS4Y2
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for RPS4Y2 Cloud-Clone Corp. CLIAs for RPS4Y2

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

RPS: S ribosomal proteins

5/6 InterPro protein domains (see all 6):

IPR013845 Ribosomal_S4e_central_region

IPR002942 S4_RNA-bd

IPR013843 Ribosomal_S4e_N

IPR000876 Ribosomal_S4e

IPR018199 Ribosomal_S4e_N_CS

Graphical View of Domain Structure for InterPro Entry Q8TD47

ProtoNet protein and cluster: Q8TD47

3 Blocks protein domains:

IPB000876 Ribosomal protein S4E

IPB002942 RNA-binding S4

IPB006646 KOW (Kyprides

UniProtKB/Swiss-Prot: RS4Y2_HUMAN, Q8TD47

Similarity: Belongs to the ribosomal protein S4e family

Similarity: Contains 1 S4 RNA-binding domain

RPS4Y2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003723	RNA binding	--	--
GO:0003735	structural constituent of ribosome	IEA	--
GO:0019843	rRNA binding	IEA	--

RPS4Y2 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for RPS4Y2

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RPS4Y2

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RPS4Y2

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RPS4Y2

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPS4Y2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate RPS4Y2
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for RPS4Y2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS4Y2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for RPS4Y2
			Sirion Biotech Customized adenovirus for overexpression of RPS4Y2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for RPS4Y2 (see all 5) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RPS4Y2 (NM_001039567)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPS4Y2
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RPS4Y2
		Sirion Biotech Customized lentivirus for stable overexpression of RPS4Y2 Customized lentivirus expression plasmids for stable overexpression of RPS4Y2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RPS4Y2
		Search LifeMap BioReagents cell lines for RPS4Y2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS4Y2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for RPS4Y2 About

See pathways by source

SuperPath

Contained pathways About

Viral mRNA Translation

CFTR translational fidelity (class I mutations)

0.83

Pathways by source See SuperPaths
Show all pathways

1 GeneGo (Thomson Reuters) Pathway for RPS4Y2

CFTR translational fidelity (class I mutations)

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RPS4Y2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/99 Interacting proteins for RPS4Y2 (ENSP00000288666⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 99)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RPS13	ENSP00000228140⁴	STRING: ENSP00000228140
RPS5	ENSP00000196551⁴	STRING: ENSP00000196551
RPS3	ENSP00000278572⁴	STRING: ENSP00000278572
RPS9	ENSP00000302896⁴	STRING: ENSP00000302896
RPS6	ENSP00000369757⁴	STRING: ENSP00000369757

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006412	translation	IEA	--

RPS4Y2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RPS4Y2 (RS4Y2)

Search CenterWatch for drugs/clinical trials and news about RPS4Y2 / RS4Y2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RPS4Y2 gene:

NM_001039567.2

Unigene Cluster for RPS4Y2:

Ribosomal protein S4, Y-linked 2

Hs.367761

Unigene Representative Sequence: NM_001039567

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000288666(uc011nbb.2)

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPS4Y2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate RPS4Y2
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for RPS4Y2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS4Y2

Clone Products:		OriGene clones in human, mouse for RPS4Y2 (see all 5) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RPS4Y2 (NM_001039567)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPS4Y2
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RPS4Y2
		Sirion Biotech Customized lentivirus for stable overexpression of RPS4Y2 Customized lentivirus expression plasmids for stable overexpression of RPS4Y2

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for RPS4Y2
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat RPS4Y2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS4Y2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS4Y2

Additional mRNA sequence: AF497481.2

1 DOTS entry:

DT.120653212

2 AceView cDNA sequences:

AF497481 NM_138963

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RPS4Y2 expression in normal human tissues (normalized intensities) RPS4Y2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

RPS4Y2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/3 selected tissues (see all 3) fully expand


Smooth Muscle (Muscoskeletal System)
Human Colonic Smooth Muscle Cells (HCoSMC)

Colon (Gastrointestinal Tract)
Human Colonic Smooth Muscle Cells (HCoSMC)

Endothelium (Cardiovascular System)
Human umbilical vein endothelial cells (HUVEC)

See RPS4Y2 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.367761

SABiosciences Custom PCR Arrays for RPS4Y2

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for RPS4Y2
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat RPS4Y2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS4Y2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS4Y2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS4Y2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for RPS4Y2 gene from 6/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RPS4⁶	40S ribosomal protein S4	93(a)	possible ortholog	4(1867724-1871061)
lizard (Anolis carolinensis)	Reptilia	RPS4X⁶	ribosomal protein S4, X-linked	93(a)	possible ortholog	GL343686.1(237404-240652)
zebrafish (Danio rerio)	Actinopterygii	rps4x⁶	ribosomal protein S4, X-linked	87(a)	1 → many	7(53088995-53094879)
fruit fly (Drosophila melanogaster)	Insecta	RpS4³	protein biosynthesis structural constituent of more	72(a)		69F6 --
worm (Caenorhabditis elegans)	Secernentea	Y43B11AR.4³	--	61(a)		IV(7083923-7084849) --
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	RPS4A⁶ RPS4B⁶	Protein component of the small (40S) ribosomal sub... Protein component of the small (40S) ribosomal sub...	68(a) 68(a)	many ↔ many many ↔ many	X(702027-703068) VIII(504476-505530)

Species with no ortholog for RPS4Y2

ENSEMBL Gene Tree for RPS4Y2 (if available)
TreeFam Gene Tree for RPS4Y2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RPS4Y2 gene

RPS4Y1² RPS4X²

3 SIMAP similar genes for RPS4Y2 using alignment to 1 protein entry: RS4Y2_HUMAN:

RPS4Y1 RPS4X RPS4XP21

RPS4Y2 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for RPS4Y2
PGOHUM00000249330

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr Y pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs35474563^1,2	C	--	22917995(+)	`CACCGC/TAGATT`	1	--	ut5¹		2		MN NA	43
rs16980548^1,2	C,F,H	--	22918577(+)	`ATTACC/TCGTTA`	1	--	int¹		11		NA MN NS EA WA CSA	327
rs13305747^1,2	C	--	22919819(+)	`CAGACA/CTGAGG`	1	--	int¹		0	--	--	--	--
rs13305800^1,2	C	--	22919840(+)	`ATGTGC/ATAAAT`	1	--	int¹		1		NA	2
rs34581739^1,2	C,F	--	22921768(+)	`CCATCG/AACAGG`	2	/S	syn¹		2		MN NA	48
rs34740450^1,2	C,F	--	22922129(+)	`AAGGGG/ATTGGT`	1	--	int¹		2		MN NA	48
rs13304464^1,2	C	--	22924348(+)	`TGTTGT/CGTCTA`	1	--	int¹		1		NA	2
rs13305220^1,2	C,F	--	22927023(+)	`TGGGGC/TCAGAA`	1	--	int¹		2		NA	4
rs34123756^1,2	C	--	22928067(+)	`GCTTTC/TGCTGG`	1	--	int¹		0	--	--	--	--
rs34194308^1,2	C,F,H	--	22928344(+)	`TAAATC/GTAGCA`	1	--	int¹		6		NS EA NA	215

HapMap Linkage Disequilibrium report for RPS4Y2 (22917954 - 22942918 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for RPS4Y2: About this table

Variant ID	Type	Subtype	PubMed ID
nsv10025	CNV	Gain	18304495

SABiosciences Cancer Mutation PCR Assays

SeqTarget long-range PCR primers for resequencing RPS4Y2

DNA2.0 Custom Variant and Variant Library Synthesis for RPS4Y2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 400030 OMIM disorders: --

3 diseases for RPS4Y2: About MalaCards

y chromosome infertility azoospermia infertility

RPS4Y2 for disorders About GeneDecksing

Export disorders for RPS4Y2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RPS4Y2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RPS4Y2)

Utopia: connect your pdf to the dynamic
world of online information

The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PubMed id 12815422)^{1, 2, 3} Skaletsky H.... Page D.C. (2003)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Primer-BLAST: a tool to design target-specific primers for polymerase chain reaction. (PubMed id 22708584)¹ Ye J....Madden T.L. (2012)
Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)¹ Povlsen L.K....Choudhary C. (2012)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)¹ Emanuele M.J....Elledge S.J. (2011)
The human RPS4 paralogue on Yq11.223 encodes a struct urally conserved ribosomal protein and is preferentially expressed during sperm atogenesis. (PubMed id 20459660)¹ Lopes A.M....Affara N.A. (2010)
Y Chromosome Infertility (PubMed id 20301513)¹ Disteche C.M. (1993)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 140032	HGNC: 18501	AceView: RPS4Y2	Ensembl:ENSG00000157828	euGenes: HUgn140032
ECgene: RPS4Y2	H-InvDB: RPS4Y2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RPS4Y2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RPS4Y2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RPS4Y2 gene:
Search GeneIP for patents involving RPS4Y2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Protease Activity Assays and Reagents		Browse Recombinant/Natural Proteins
	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for RPS4Y2
	Browse OriGene qPCR primer pairs and template standards		OriGene Protein Over-expression Lysate for RPS4Y2
	OriGene Custom Mass Spec		OriGene clones in human, mouse for RPS4Y2
	OriGene qSTAR qPCR primer pairs in human, mouse for RPS4Y2		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	Browse OriGene ORF clones		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for RPS4Y2		OriGene Custom Protein Services for RPS4Y2

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RPS4Y2
	QIAGEN SeqTarget long-range PCR primers for resequencing RPS4Y2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS4Y2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS4Y2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS4Y2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS4Y2

	GenScript Custom Purified and Recombinant Proteins Services for RPS4Y2		GenScript cDNA clones with any tag delivered in your preferred vector for RPS4Y2
	GenScript Custom Assay Services for RPS4Y2		GenScript Custom Superior Antibodies Services for RPS4Y2
	GenScript Custom overexpressing Cell Line Services for RPS4Y2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in RPS4Y2 promoter
	Search Chromatin IP Primers for RPS4Y2
	RT² qPCR Primer Assay in human, mouse / rat RPS4Y2
	Search GNC Networks for RPS4Y2
	SABiosciences Custom PCR Arrays for RPS4Y2

Search Tocris compounds for RPS4Y2 (RS4Y2)

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Biologicals
	Novus Tissue Slides

	Antibodies for RPS4Y2
	See all of Abcam's Antibodies, Kits and Proteins for RPS4Y2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for RPS4Y2
	Antibodies for RPS4Y2
	ELISAs for RPS4Y2
	CLIAs for RPS4Y2

Search LifeMap BioReagents cell lines for RPS4Y2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS4Y2

	Browse SwitchGear 3'UTR luciferase reporter plasmids for RPS4Y2
	Browse SwitchGear Promoter luciferase reporter plasmids for RPS4Y2

Search ThermoFisher Antibodies for RPS4Y2

Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RPS4Y2

	inGenious Targeting Laboratory - Custom generated mouse model solutions for RPS4Y2
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RPS4Y2

Customized:

	lentivirus for stable overexpression of RPS4Y2
	lentivirus expression plasmids for stable overexpression of RPS4Y2
	adenovirus for overexpression of RPS4Y2

LSBio Antibodies in human, mouse, rat for RPS4Y2

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes RPS4Y2 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

RPS4Y2 Gene

Ribosomal Protein S4, Y-Linked 2

Aliases
for RPS4Y2 gene

Summaries
for RPS4Y2 gene

Genomic Views
for RPS4Y2 gene

Proteins
for RPS4Y2 gene

Protein Domains /
Families
for RPS4Y2 gene

Function
for RPS4Y2 gene

Pathways & Interactions
for RPS4Y2 gene

Drugs & Compounds
for RPS4Y2 gene

Transcripts
for RPS4Y2 gene

Expression
for RPS4Y2 gene

Orthologs
for RPS4Y2 gene

Paralogs
for RPS4Y2 gene

Genomic Variants
for RPS4Y2 gene

Disorders / Diseases
for RPS4Y2 gene

Publications
for RPS4Y2 gene

External Searches for RPS4Y2 gene

Genome Databases showing RPS4Y2 gene

Other Databases showing RPS4Y2 gene

Specialized Databases showing RPS4Y2 gene

Intellectual Property
for RPS4Y2 gene

Products
for RPS4Y2 gene

View Random Gene

Advanced Search

Export list of displayed genes

RPS4Y2 Gene

Ribosomal Protein S4, Y-Linked 2

Aliasesfor RPS4Y2 gene

Summariesfor RPS4Y2 gene

Genomic Viewsfor RPS4Y2 gene

Proteinsfor RPS4Y2 gene

Protein Domains /Familiesfor RPS4Y2 gene

Functionfor RPS4Y2 gene

Pathways & Interactionsfor RPS4Y2 gene

Drugs & Compoundsfor RPS4Y2 gene

Transcriptsfor RPS4Y2 gene

Expression for RPS4Y2 gene

Orthologsfor RPS4Y2 gene

Paralogsfor RPS4Y2 gene

Genomic Variantsfor RPS4Y2 gene

Disorders / Diseasesfor RPS4Y2 gene

Publicationsfor RPS4Y2 gene

External Searches for RPS4Y2 gene

Genome Databases showing RPS4Y2 gene

Other Databases showing RPS4Y2 gene

Specialized Databases showing RPS4Y2 gene

Intellectual Propertyfor RPS4Y2 gene

Productsfor RPS4Y2 gene

View Random Gene

Aliases
for RPS4Y2 gene

Summaries
for RPS4Y2 gene

Genomic Views
for RPS4Y2 gene

Proteins
for RPS4Y2 gene

Protein Domains /
Families
for RPS4Y2 gene

Function
for RPS4Y2 gene

Pathways & Interactions
for RPS4Y2 gene

Drugs & Compounds
for RPS4Y2 gene

Transcripts
for RPS4Y2 gene

Expression
for RPS4Y2 gene

Orthologs
for RPS4Y2 gene

Paralogs
for RPS4Y2 gene

Genomic Variants
for RPS4Y2 gene

Disorders / Diseases
for RPS4Y2 gene

Publications
for RPS4Y2 gene

Intellectual Property
for RPS4Y2 gene

Products
for RPS4Y2 gene