Aliases for RPS4Y2 Gene
Aliases for RPS4Y2 Gene
External Ids for RPS4Y2 Gene
- HGNC: 18501
- Entrez Gene: 140032
- Ensembl: ENSG00000280969
- OMIM: 400030
- UniProtKB: Q8TD47
Previous HGNC Symbols for RPS4Y2 Gene
- RPS4Y2P
Previous GeneCards Identifiers for RPS4Y2 Gene
- GC0YP022073
- GC0YP021763
- GC0YP021256
- GC0YP021327
- GC0YP022917
- GC0YP016504
Summaries for RPS4Y2 Gene
-
The protein encoded by this gene is a ribosomal protein that is highly similar to RPS4Y1. This gene is located in the male-specific region of the Y chromosome. [provided by RefSeq, Aug 2012]
GeneCards Summary for RPS4Y2 Gene
RPS4Y2 (Ribosomal Protein S4, Y-Linked 2) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. GO annotations related to this gene include RNA binding and rRNA binding. An important paralog of this gene is RPS4Y1.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS4Y2 Gene
Genomics for RPS4Y2 Gene
Regulatory Elements for RPS4Y2 Gene
Regulatory Element Products
Genomic Location for RPS4Y2 Gene
- Chromosome:
- Y
- Start:
- 20,756,068 bp from pter
- End:
- 20,781,056 bp from pter
- Size:
- 24,989 bases
- Orientation:
- Plus strand
Genomic View for RPS4Y2 Gene
Genes around RPS4Y2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Yq11.223 by Ensembl
- Yq11.223 by Entrez Gene
- Yq11.223 by HGNC
RPS4Y2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RPS4Y2 Gene
Proteins for RPS4Y2 Gene
-
Protein details for RPS4Y2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8TD47-RS4Y2_HUMAN
- Recommended name:
- 40S ribosomal protein S4, Y isoform 2
- Protein Accession:
- Q8TD47
- A6NIR6
Protein attributes for RPS4Y2 Gene
- Size:
- 263 amino acids
- Molecular mass:
- 29295 Da
- Quaternary structure:
- No Data Available
Protein Expression for RPS4Y2 Gene
Post-translational modifications for RPS4Y2 Gene
Other Protein References for RPS4Y2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Abcam antibodies for RPS4Y2
- antibodies-online Antibodies for RPS4Y2: See all 4
- Search GeneTex for Antibodies for RPS4Y2
Protein Products
-
OriGene Purified Proteins for RPS4Y2
- Search Origene for MassSpec and Protein Over-expression Lysates for RPS4Y2
- Origene Custom Protein Services for RPS4Y2
- Search GeneTex for Proteins for RPS4Y2
No data available for DME Specific Peptides for RPS4Y2 Gene
Domains & Families for RPS4Y2 Gene
Gene Families for RPS4Y2 Gene
Protein Domains for RPS4Y2 Gene
Suggested Antigen Peptide Sequences for RPS4Y2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8TD47- Family:
-
- Belongs to the eukaryotic ribosomal protein eS4 family.
Function for RPS4Y2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
| GO:0003723 | RNA binding | IEA | -- |
| GO:0003735 | structural constituent of ribosome | IBA | -- |
| GO:0019843 | rRNA binding | IEA | -- |
Phenotypes for RPS4Y2 Gene
- GenomeRNAi human phenotypes for RPS4Y2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for RPS4Y2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for RPS4Y2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RPS4Y2 gene
- Search ViGene Biosciences for RPS4Y2
CRISPR Products
-
OriGene CRISPR knockouts for RPS4Y2
-
Santa Cruz Biotechnology (SCBT) CRISPR for RPS4Y2
- GenScript: Design CRISPR guide RNA sequences for RPS4Y2
miRNA Products
- Search ViGene Biosciences for RPS4Y2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for RPS4Y2
- Browse OriGene Inhibitory RNA Products For RPS4Y2
-
ViGene Biosciences ready-to-package AAV shRNAs for RPS4Y2 gene
Clone Products
-
OriGene ORF clones in human for RPS4Y2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- VectorBuilder custom plasmid, inducible vectors for RPS4Y2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RPS4Y2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for RPS4Y2
-
ViGene Biosciences adenoviral particle packaged cDNA for RPS4Y2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for RPS4Y2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RPS4Y2 gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RPS4Y2 Gene
Localization for RPS4Y2 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| mitochondrion | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005575 | cellular_component | ND | -- |
| GO:0005622 | intracellular | IEA | -- |
| GO:0005840 | ribosome | IEA | -- |
| GO:0022627 | cytosolic small ribosomal subunit | IBA | -- |
| GO:0030529 | intracellular ribonucleoprotein complex | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS4Y2 Gene
Pathways & Interactions for RPS4Y2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Viral mRNA Translation |
.77
.56
|
|
| 2 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | ||
| 3 | Influenza Viral RNA Transcription and Replication | ||
| 4 | rRNA processing in the nucleus and cytosol |
.89
|
|
| 5 | HIV Life Cycle |
.45
|
|
Pathways by source for RPS4Y2 Gene
32 Reactome pathways for RPS4Y2 Gene
1 KEGG pathway for RPS4Y2 Gene
1 GeneGo (Thomson Reuters) pathway for RPS4Y2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006412 | translation | IBA | -- |
| GO:0008150 | biological_process | ND | -- |
No data available for SIGNOR curated interactions for RPS4Y2 Gene
Transcripts for RPS4Y2 Gene
mRNA/cDNA for RPS4Y2 Gene
- (1) REFSEQ mRNAs :
- (2) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for RPS4Y2
-
Santa Cruz Biotechnology (SCBT) CRISPR for RPS4Y2
- GenScript: Design CRISPR guide RNA sequences for RPS4Y2
miRNA Products
- Search ViGene Biosciences for RPS4Y2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for RPS4Y2
- Browse OriGene Inhibitory RNA Products For RPS4Y2
-
ViGene Biosciences ready-to-package AAV shRNAs for RPS4Y2 gene
Clone Products
-
OriGene ORF clones in human for RPS4Y2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- VectorBuilder custom plasmid, inducible vectors for RPS4Y2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RPS4Y2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for RPS4Y2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Endothelium (Cardiovascular System)
mRNA differential expression in normal tissues according to GTEx for RPS4Y2 Gene
This gene is overexpressed in Testis (x22.4) and Prostate (x17.2).
This gene is overexpressed in Heart (39.7) and Brain (29.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPS4Y2 Gene
NURSA nuclear receptor signaling pathways regulating expression of RPS4Y2 Gene:
RPS4Y2SOURCE GeneReport for Unigene cluster for RPS4Y2 Gene:
Hs.367761Primer Products
-
OriGene qPCR primer pairs for RPS4Y2
No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS4Y2 Gene
Orthologs for RPS4Y2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | RPS4Y2 34 |
|
||
| dog (Canis familiaris) |
Mammalia | RPS4X 34 |
|
||
| cow (Bos Taurus) |
Mammalia | RPS4Y1 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Rps4y2 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | RpS4 36 |
|
|
|
| worm (Caenorhabditis elegans) |
Secernentea | Y43B11AR.4 36 |
|
|
- Species where no ortholog for RPS4Y2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- zebrafish (Danio rerio)
Paralogs for RPS4Y2 Gene
(2) SIMAP similar genes for RPS4Y2 Gene using alignment to 1 proteins:
Pseudogenes.org Pseudogenes for RPS4Y2 Gene
Variants for RPS4Y2 Gene
| SNP ID | Clin | Chr 0Y pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000117736 | -- | 20,772,154(+) | CCTCA(C/G)TGTCC | intron-variant | |
| rs1000170809 | -- | 20,773,684(+) | TTCAC(A/G)TAGCT | intron-variant | |
| rs1000482247 | -- | 20,763,878(+) | TGACT(A/G)AAATA | intron-variant | |
| rs1002153232 | -- | 20,756,795(+) | AAGAA(A/G)CACTT | reference, synonymous-codon | |
| rs1002516877 | -- | 20,765,914(+) | TGGAA(G/T)ATACA | intron-variant |
Gene Damage Index Score:
0.14;
3.08% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for RPS4Y2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RPS4Y2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS4Y2 Gene
Disorders for RPS4Y2 Gene
Relevant External Links for RPS4Y2
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- RPS4Y2
No disorders were found for RPS4Y2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPS4Y2 Gene
Publications for RPS4Y2 Gene
- The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H. … Page D.C. (Nature 2003) 2 3 4 64
- Repression of rRNA transcription by PARIS contributes to Parkinson's disease. (PMID: 25315684) Kang H. … Shin J.H. (Neurobiol. Dis. 2015) 3 64
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
- A new system for naming ribosomal proteins. (PMID: 24524803) Ban N. … Yusupov M. (Curr. Opin. Struct. Biol. 2014) 4 64
- Primer-BLAST: a tool to design target-specific primers for polymerase chain reaction. (PMID: 22708584) Ye J. … Madden T.L. (BMC Bioinformatics 2012) 3 64
Products for RPS4Y2 Gene
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- OriGene Purified Proteins for RPS4Y2
- Search Origene for MassSpec and Protein Over-expression Lysates for RPS4Y2
- Origene Custom Protein Services for RPS4Y2
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for RPS4Y2
- Browse OriGene Inhibitory RNA Products For RPS4Y2
- OriGene qPCR primer pairs for RPS4Y2
- OriGene CRISPR knockouts for RPS4Y2
- OriGene ORF clones in human for RPS4Y2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA ORF clone for RPS4Y2 in any vector
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- Abcam antibodies for RPS4Y2
- Find your target
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- Search GeneTex for Antibodies for RPS4Y2
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- ViGene Biosciences adenoviral particle packaged cDNA for RPS4Y2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for RPS4Y2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for RPS4Y2 gene
- Search ViGene Biosciences for RPS4Y2
- Horizon Cell Lines for RPS4Y2
- Cyagen custom Knockout/knockin (KOKI) mouse models for RPS4Y2
- VectorBuilder custom plasmid, inducible vectors for RPS4Y2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RPS4Y2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for RPS4Y2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
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- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
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- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
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- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer