Aliases for RPS4Y2 Gene
Aliases for RPS4Y2 Gene
External Ids for RPS4Y2 Gene
- HGNC: 18501
- Entrez Gene: 140032
- Ensembl: ENSG00000280969
- OMIM: 400030
- UniProtKB: Q8TD47
Previous HGNC Symbols for RPS4Y2 Gene
- RPS4Y2P
Previous GeneCards Identifiers for RPS4Y2 Gene
- GC0YP022073
- GC0YP021763
- GC0YP021256
- GC0YP021327
- GC0YP022917
- GC0YP016504
Summaries for RPS4Y2 Gene
-
The protein encoded by this gene is a ribosomal protein that is highly similar to RPS4Y1. This gene is located in the male-specific region of the Y chromosome. [provided by RefSeq, Aug 2012]
GeneCards Summary for RPS4Y2 Gene
RPS4Y2 (Ribosomal Protein S4, Y-Linked 2) is a Protein Coding gene. Diseases associated with RPS4Y2 include Spermatogenic Failure, Y-Linked, 2. Among its related pathways are Viral mRNA Translation and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. Gene Ontology (GO) annotations related to this gene include RNA binding and rRNA binding. An important paralog of this gene is RPS4Y1.
Additional gene information for RPS4Y2 Gene
- Monarch Initiative
- Search for RPS4Y2 at DataMed
- Search for RPS4Y2 at HumanCyc
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS4Y2 Gene
Genomics for RPS4Y2 Gene
GeneHancer (GH) Regulatory Elements for RPS4Y2 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH0YI020756 | Promoter | 0.5 | EPDnew | 550.8 | +0.1 | 52 | 0.1 | RPS4Y2 HSFY4P |
Regulatory Element Products
Genomic Locations for RPS4Y2 Gene
- chrY:20,756,068-20,781,056
- (GRCh38/hg38)
- Size:
- 24,989 bases
- Orientation:
- Plus strand
- chrY:22,917,954-22,942,918
- (GRCh37/hg19)
Genomic View for RPS4Y2 Gene
- Cytogenetic band:
-
- Yq11.223 by Ensembl
- Yq11.223 by Entrez Gene
- Yq11.223 by HGNC


RefSeq DNA sequence for RPS4Y2 Gene
Proteins for RPS4Y2 Gene
-
Protein details for RPS4Y2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8TD47-RS4Y2_HUMAN
- Recommended name:
- 40S ribosomal protein S4, Y isoform 2
- Protein Accession:
- Q8TD47
- A6NIR6
Protein attributes for RPS4Y2 Gene
- Size:
- 263 amino acids
- Molecular mass:
- 29295 Da
- Quaternary structure:
- No Data Available
Protein Expression for RPS4Y2 Gene
Post-translational modifications for RPS4Y2 Gene
Other Protein References for RPS4Y2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Invitrogen Antibodies for RPS4Y2
- antibodies-online: Search results for 4 available RPS4Y2 Antibodies ranked by validation data
- Compare Top RPS4Y2 Antibodies
-
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Protein Products
-
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- Search GeneTex for Proteins for RPS4Y2
Assay Products
No data available for DME Specific Peptides for RPS4Y2 Gene
Domains & Families for RPS4Y2 Gene
Gene Families for RPS4Y2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Ribosomal proteins
Protein Domains for RPS4Y2 Gene
Suggested Antigen Peptide Sequences for RPS4Y2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8TD47- Family:
-
- Belongs to the eukaryotic ribosomal protein eS4 family.
Function for RPS4Y2 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003674 | molecular_function | ND | -- |
GO:0003723 | RNA binding | IBA | -- |
GO:0003735 | structural constituent of ribosome | IBA | -- |
GO:0019843 | rRNA binding | IEA | -- |
Phenotypes for RPS4Y2 Gene
- GenomeRNAi human phenotypes for RPS4Y2:
Animal Model Products
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-
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-
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-
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-
Vectors and viruses for KO, Activation, Repression, and more
-
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
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-
Horizon Cell Lines for RPS4Y2
-
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No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RPS4Y2 Gene
Localization for RPS4Y2 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005575 | cellular_component | ND | -- |
GO:0005622 | intracellular | IEA | -- |
GO:0005840 | ribosome | IEA | -- |
GO:0022627 | cytosolic small ribosomal subunit | IBA | -- |
GO:0030529 | intracellular ribonucleoprotein complex | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for RPS4Y2 Gene
Pathways & Interactions for RPS4Y2 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Viral mRNA Translation |
.77
.55
|
|
2 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | ||
3 | Influenza Viral RNA Transcription and Replication | ||
4 | rRNA processing in the nucleus and cytosol |
.89
|
|
5 | HIV Life Cycle |
.45
|
Pathways by source for RPS4Y2 Gene
32 Reactome pathways for RPS4Y2 Gene
1 KEGG pathway for RPS4Y2 Gene
1 GeneGo (Thomson Reuters) pathway for RPS4Y2 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006412 | translation | IBA | -- |
GO:0008150 | biological_process | ND | -- |
No data available for SIGNOR curated interactions for RPS4Y2 Gene
Transcripts for RPS4Y2 Gene
mRNA/cDNA for RPS4Y2 Gene
- (1) REFSEQ mRNAs :
- (2) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for RPS4Y2
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RPS4Y2
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-
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for RPS4Y2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Endothelium (Cardiovascular System)
mRNA differential expression in normal tissues according to GTEx for RPS4Y2 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPS4Y2 Gene
NURSA nuclear receptor signaling pathways regulating expression of RPS4Y2 Gene:
RPS4Y2SOURCE GeneReport for Unigene cluster for RPS4Y2 Gene:
Hs.367761Primer Products
-
OriGene qPCR primer pairs for RPS4Y2
- genomics-online: primer clones - Search results for available RPS4Y2 gene related products
No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS4Y2 Gene
Orthologs for RPS4Y2 Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | RPS4Y2 33 |
|
||
dog (Canis familiaris) |
Mammalia | RPS4X 33 |
|
||
cow (Bos Taurus) |
Mammalia | RPS4Y1 33 |
|
||
rat (Rattus norvegicus) |
Mammalia | Rps4y2 33 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | RpS4 35 |
|
|
|
worm (Caenorhabditis elegans) |
Secernentea | Y43B11AR.4 35 |
|
|
- Species where no ortholog for RPS4Y2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- zebrafish (Danio rerio)
Paralogs for RPS4Y2 Gene
(2) SIMAP similar genes for RPS4Y2 Gene using alignment to 1 proteins:
Pseudogenes.org Pseudogenes for RPS4Y2 Gene
Variants for RPS4Y2 Gene
SNP ID | Clin | Chr 0Y pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000117736 | -- | 20,772,154(+) | G/C | intron_variant | |
rs1000170809 | -- | 20,773,684(+) | G/A | intron_variant | |
rs1000482247 | -- | 20,763,878(+) | G/A | intron_variant | |
rs1002153232 | -- | 20,756,795(+) | G/A | coding_sequence_variant, synonymous_variant | |
rs1002516877 | -- | 20,765,914(+) | G/T | intron_variant |
Additional Variant Information for RPS4Y2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RPS4Y2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS4Y2 Gene
Disorders for RPS4Y2 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
spermatogenic failure, y-linked, 2 |
|
|
Additional Disease Information for RPS4Y2
No data available for UniProtKB/Swiss-Prot and Genatlas for RPS4Y2 Gene
Publications for RPS4Y2 Gene
- The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H … Page DC (Nature 2003) 2 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- Repression of rRNA transcription by PARIS contributes to Parkinson's disease. (PMID: 25315684) Kang H … Shin JH (Neurobiology of disease 2015) 3 58
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
- A new system for naming ribosomal proteins. (PMID: 24524803) Ban N … Yusupov M (Current opinion in structural biology 2014) 4 58
Products for RPS4Y2 Gene
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- Invitrogen Antibodies for RPS4Y2
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Sources for RPS4Y2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
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- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew