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RPS4Y2 Gene(Protein Coding)

Ribosomal Protein S4, Y-Linked 2

GCID:
GC0YP020756
GIFtS:
39
Genes Participants
UDN Logo

Aliases for RPS4Y2 Gene

Aliases for RPS4Y2 Gene

  • Ribosomal Protein S4, Y-Linked 2 2 3 5
  • Ribosomal Protein S4, Y-Linked 2 Pseudogene 2 3
  • RPS4Y2P 3 4
  • 40S Ribosomal Protein S4, Y 3

External Ids for RPS4Y2 Gene

Previous HGNC Symbols for RPS4Y2 Gene

  • RPS4Y2P

Previous GeneCards Identifiers for RPS4Y2 Gene

  • GC0YP022073
  • GC0YP021763
  • GC0YP021256
  • GC0YP021327
  • GC0YP022917
  • GC0YP016504

Summaries for RPS4Y2 Gene

Entrez Gene Summary for RPS4Y2 Gene

  • The protein encoded by this gene is a ribosomal protein that is highly similar to RPS4Y1. This gene is located in the male-specific region of the Y chromosome. [provided by RefSeq, Aug 2012]

GeneCards Summary for RPS4Y2 Gene

RPS4Y2 (Ribosomal Protein S4, Y-Linked 2) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation. GO annotations related to this gene include RNA binding and rRNA binding. An important paralog of this gene is RPS4Y1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS4Y2 Gene

Genomics for RPS4Y2 Gene

Products:

  1. Regulatory Element

Regulatory Elements for RPS4Y2 Gene


Transcription factor binding sites by QIAGEN in the RPS4Y2 gene promoter:

Genomic Location for RPS4Y2 Gene

Chromosome:
Y
Start:
20,756,068 bp from pter
End:
20,781,056 bp from pter
Size:
24,989 bases
Orientation:
Plus strand

Genomic View for RPS4Y2 Gene

Genes around RPS4Y2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS4Y2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS4Y2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for RPS4Y2 Gene

Proteins for RPS4Y2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for RPS4Y2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TD47-RS4Y2_HUMAN
    Recommended name:
    40S ribosomal protein S4, Y isoform 2
    Protein Accession:
    Q8TD47
    Secondary Accessions:
    • A6NIR6

    Protein attributes for RPS4Y2 Gene

    Size:
    263 amino acids
    Molecular mass:
    29295 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RPS4Y2 Gene

Proteomics data for RPS4Y2 Gene at MOPED

Protein Expression for RPS4Y2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for RPS4Y2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPS4Y2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPS4Y2 Gene

Domains & Families for RPS4Y2 Gene

Gene Families for RPS4Y2 Gene

HGNC:

Protein Domains for RPS4Y2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RPS4Y2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TD47

UniProtKB/Swiss-Prot:

RS4Y2_HUMAN :
  • Contains 1 S4 RNA-binding domain.
  • Belongs to the ribosomal protein S4e family.
Domain:
  • Contains 1 S4 RNA-binding domain.
Family:
  • Belongs to the ribosomal protein S4e family.
genes like me logo Genes that share domains with RPS4Y2: view

Function for RPS4Y2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Gene Ontology (GO) - Molecular Function for RPS4Y2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with RPS4Y2: view

Phenotypes for RPS4Y2 Gene

GenomeRNAi human phenotypes for RPS4Y2:
genes like me logo Genes that share phenotypes with RPS4Y2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RPS4Y2 Gene

Localization for RPS4Y2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS4Y2 Gene COMPARTMENTS Subcellular localization image for RPS4Y2 gene
Compartment Confidence
cytosol 5
mitochondrion 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RPS4Y2 Gene

Pathways & Interactions for RPS4Y2 Gene

genes like me logo Genes that share pathways with RPS4Y2: view

Pathways by source for RPS4Y2 Gene

1 KEGG pathway for RPS4Y2 Gene
1 GeneGo (Thomson Reuters) pathway for RPS4Y2 Gene

Interacting Proteins for RPS4Y2 Gene

Gene Ontology (GO) - Biological Process for RPS4Y2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA,IBA --
genes like me logo Genes that share ontologies with RPS4Y2: view

No data available for SIGNOR curated interactions for RPS4Y2 Gene

Drugs & Compounds for RPS4Y2 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for RPS4Y2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for RPS4Y2 Gene

(2) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS4Y2 Gene

No ASD Table

Relevant External Links for RPS4Y2 Gene

GeneLoc Exon Structure for
RPS4Y2
ECgene alternative splicing isoforms for
RPS4Y2

Expression for RPS4Y2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for RPS4Y2 Gene

mRNA expression in normal human tissues for RPS4Y2 Gene
mRNA expression by GTEx for RPS4Y2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RPS4Y2 Gene

This gene is overexpressed in Testis (x22.4) and Prostate (x17.2).

Protein differential expression in normal tissues from HIPED for RPS4Y2 Gene

This gene is overexpressed in Heart (39.7) and Brain (29.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for RPS4Y2 Gene



SOURCE GeneReport for Unigene cluster for RPS4Y2 Gene Hs.367761

genes like me logo Genes that share expression patterns with RPS4Y2: view

Protein tissue co-expression partners for RPS4Y2 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for RPS4Y2 Gene

Orthologs for RPS4Y2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RPS4Y2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia RPS4Y1 35
  • 79.72 (n)
  • 90.87 (a)
dog
(Canis familiaris)
 Mammalia RPS4X 35
  • 80.86 (n)
  • 91.63 (a)
chimpanzee
(Pan troglodytes)
 Mammalia RPS4Y2 35
  • 98.99 (n)
  • 97.34 (a)
rat
(Rattus norvegicus)
 Mammalia Rps4y2 35
  • 73.82 (n)
  • 86.59 (a)
fruit fly
(Drosophila melanogaster)
 Insecta RpS4 37
  • 72 (a)
worm
(Caenorhabditis elegans)
 Secernentea Y43B11AR.4 37
  • 61 (a)
Species with no ortholog for RPS4Y2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for RPS4Y2 Gene

ENSEMBL:
Gene Tree for RPS4Y2 (if available)
TreeFam:
Gene Tree for RPS4Y2 (if available)

Paralogs for RPS4Y2 Gene

Paralogs for RPS4Y2 Gene

(2) SIMAP similar genes for RPS4Y2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RPS4Y2: view

Variants for RPS4Y2 Gene

Sequence variations from dbSNP and Humsavar for RPS4Y2 Gene

SNP ID Clin Chr 0Y pos Sequence Context AA Info Type
rs9786516 -- 20,772,223(+) gtcat(A/G)gaaat intron-variant
rs13303733 -- 20,762,643(+) cgctg(A/C)aacct intron-variant
rs13303931 -- 20,762,642(+) tcgct(A/G)caacc intron-variant
rs13303993 -- 20,766,813(+) CCTCA(A/G)CAGCT intron-variant
rs13304464 -- 20,762,462(+) TGTTG(C/T)GTCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPS4Y2 Gene

Variant ID Type Subtype PubMed ID
nsv10025 CNV Gain 18304495

Variation tolerance for RPS4Y2 Gene

Gene Damage Index Score: 0.14; 3.08% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RPS4Y2 Gene

Disorders for RPS4Y2 Gene

Relevant External Links for RPS4Y2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPS4Y2

No disorders were found for RPS4Y2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPS4Y2 Gene

Publications for RPS4Y2 Gene

  1. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H. … Page D.C. (Nature 2003) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Primer-BLAST: a tool to design target-specific primers for polymerase chain reaction. (PMID: 22708584) Ye J. … Madden T.L. (BMC Bioinformatics 2012) 3
  4. The human RPS4 paralogue on Yq11.223 encodes a structurally conserved ribosomal protein and is preferentially expressed during spermatogenesis. (PMID: 20459660) Lopes A.M. … Affara N.A. (BMC Mol. Biol. 2010) 3
  5. Y Chromosome Infertility (PMID: 20301513) Pagon R.A. … Stephens K. ( 1993) 3

Products for RPS4Y2 Gene

Sources for RPS4Y2 Gene

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