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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPS4X Gene

protein-coding   GIFtS: 61
GCID: GC0XM071475

ribosomal protein S4, X-linked
 Explore 12 diseases affiliated with
RPS4X via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RPS4X    

Aliases
for RPS4X gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ribosomal Protein S4, X-Linked1 2     Single Copy Abundant MRNA Protein2 3
CCG21 2 3 5     FLJ405951
SCAR1 2 3 5     40S Ribosomal Protein S4, X Isoform2
RPS41 2 3     Cell Cycle Gene 22
SCR101 2 3     Ribosomal Protein S4X Isoform2
DXS3061 2     Single-Copy Abundant MRNA2
S41 2     

External Ids:    HGNC: 104241   Entrez Gene: 61912   Ensembl: ENSG000001980347   OMIM: 3127605   UniProtKB: P627013   

Export aliases for RPS4X gene to outside databases

Previous GC identifers: GC0XM067219 GC0XM068727 GC0XM069725 GC0XM070359 GC0XM071275 GC0XM071408 GC0XM065247


Summaries
for RPS4X gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RPS4X:
Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S
subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins.
This gene encodes ribosomal protein S4, a component of the 40S subunit. Ribosomal protein S4 is the only ribosomal
protein known to be encoded by more than one gene, namely this gene and ribosomal protein S4, Y-linked (RPS4Y). The 2
isoforms encoded by these genes are not identical, but are functionally equivalent. Ribosomal protein S4 belongs to
the S4E family of ribosomal proteins. This gene is not subject to X-inactivation. It has been suggested that
haploinsufficiency of the ribosomal protein S4 genes plays a role in Turner syndrome; however, this hypothesis is
controversial. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this
gene dispersed through the genome. (provided by RefSeq, Jul 2008)

Gene Wiki entry for RPS4X


Genomic Views
for RPS4X gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_011669.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPS4X gene promoter:
         Oct-B1   Pax-5   p53   CUTL1   FAC1   NRF-2   POU2F1   POU2F1a   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RPS4X promoter sequence
   Search SABiosciences Chromatin IP Primers for RPS4X

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS4X


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq13.1   Ensembl cytogenetic band:  Xq13.1   HGNC cytogenetic band: Xq13.1

RPS4X Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS4X gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM071475:  view genomic region     (about GC identifiers)

Start:
 71,475,529 bp from pter      End:
 71,497,150 bp from pter
Size:
 21,622 bases      Orientation:
 minus strand

Proteins
for RPS4X gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RS4X_HUMAN, P62701 (See protein sequence)
Recommended Name: 40S ribosomal protein S4, X isoform  
Size: 263 amino acids; 29598 Da
Subunit: Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1,
HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0,
RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs
Subcellular location: Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs
Secondary accessions: P12631 P12750 P27576 P55831 Q14727 Q6IPY4

Explore the universe of human proteins at neXtProt for RPS4X: NX_P62701

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P62701

    • RPS4X Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000998.1  
    ENSEMBL proteins: 
     ENSP00000362744   ENSP00000362729  
    Reactome Protein details: P62701
    Human Recombinant Protein Products: 
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    Novus Biologicals RPS4X Protein
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RPS4X

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005840ribosome IDA15883184
    GO:0005844polysome IDA8139551
    GO:0015935small ribosomal subunit IDA8139551
    GO:0022627cytosolic small ribosomal subunit NAS2124517


    RPS4X for ontologies           About GeneDecksing



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    Uscn Antibodies for RPS4X
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    Uscn ELISAs and CLIAs for RPS4X

    Protein Domains /
    Families
    for RPS4X gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RPS4X for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR013845 Ribosomal_S4e_central
     IPR002942 S4_RNA-bd
     IPR013843 Ribosomal_S4e_N
     IPR000876 Ribosomal_S4e
     IPR018199 Ribosomal_S4e_N_CS

    Graphical View of Domain Structure for InterPro Entry P62701

    ProtoNet protein and cluster: P62701

    2 Blocks protein families:
    IPB000876 Ribosomal protein S4E
    IPB002942 RNA-binding S4


    UniProtKB/Swiss-Prot: RS4X_HUMAN, P62701
    Similarity: Belongs to the ribosomal protein S4e family
    Similarity: Contains 1 S4 RNA-binding domain


    Function
    for RPS4X gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:
         Genatlas biochemistry entry for RPS4X:
    40S ribosomal protein S4,29kDa,X-linked isoform,escaping inactivation

    miRNA
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    Inhib. RNA
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    OriGene shRNA RFP: RPS4X
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    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPS4X (see all 4)
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    Cell Line
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    Search LifeMap BioReagents cell lines for RPS4X

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding ----
    GO:0003735structural constituent of ribosome IMP8358435
    GO:0019843rRNA binding IEA--


    RPS4X for ontologies           About GeneDecksing


    10 GenomeRNAi human phenotypes for RPS4X:
     Decreased Hepatitis C virus re  Decreased homologous recombina  Decreased viability  Decreased viability of wild-ty 
     Increased S DNA content  Increased circadian period len  Increased gamma-H2AX phosphory  Nucleolar pre-40S maturation d 
     S arrest  Synthetic lethal with Ras 


    Pathways & Interactions
    for RPS4X gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Synthesis of PB1-F2
    8/26 pathways (see all 26)
    		Viral Protein Synthesis1.00
    		Cytoplasmic Ribosomal Proteins0.86
    		Viral mRNA Translation1.00
    		CFTR translational fidelity (class I mutations)0.83
    		Influenza Viral RNA Transcription and Replication1.00
    		SMG6 Cleaves mRNA with Premature Termination Codon0.80
    		Synthesis of nascent polypeptide containing signal sequence1.00
    		L13a-mediated translational silencing of Ceruloplasmin expression0.79
    2Translation initiation complex formation
    		Translation initiation complex formation1.00
    		Ribosomal scanning and start codon recognition0.96
    		Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.98
    		Formation of the ternary complex, and subsequently, the 43S complex0.87
    3Metabolism of mRNA
    		Metabolism of mRNA1.00
    		Metabolism of RNA0.92
    4Disease
    		Disease1.00
    5Generic Transcription Pathway
    		Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPS4X
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPS4X 
        Cytoplasmic Ribosomal Proteins

    5/32        Reactome Pathways for RPS4X (see all 32)
        Formation of a pool of free 40S subunits
    Synthesis of PB1-F2
    SMG6 Cleaves mRNA with Premature Termination Codon
    Influenza Life Cycle
    Viral mRNA Translation


    1         Kegg Pathway  (Kegg details for RPS4X):
        Ribosome


    RPS4X for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RPS4X

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/545 Interacting proteins for RPS4X (P627012, 3 ENSP000003627444) via UniProtKB, MINT, STRING, and/or I2D (see all 545)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=2 
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    HIST1H4EP628053I2D: score=2 
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--
    GO:0006415translational termination TAS--


    RPS4X for ontologies           About GeneDecksing



    Drugs & Compounds
    for RPS4X gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RPS4X
    Search CenterWatch for drugs/clinical trials and news about RPS4X / RS4X 

    Transcripts
    for RPS4X gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RPS4X gene: 
    NM_001007.4  

    Unigene Cluster for RPS4X:

    Ribosomal protein S4, X-linked
    Hs.118076  [show with all ESTs]
    Unigene Representative Sequence: AK097914
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000470671 ENST00000492695 ENST00000316084(uc004ear.3) ENST00000486733(uc011mqb.2)
    ENST00000373626

    miRNA
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPS4X (see all 7)
    OriGene shRNA RFP: RPS4X
    OriGene siRNA: RPS4X
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS4X
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPS4X (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPS4X (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: RPS4X (NM_001007)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS4X
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS4X

    Additional cDNA sequence: 

    AK097914.1 AK222479.1 AK293663.1 AK311745.1 BC000472.2 BC002569.1 BC007308.1 BC071662.1 
    BC100903.1 BC100904.1 CR456735.1 M22146.1 M58458.1 Z70767.1 

    24/108 DOTS entries (see all 108):

    DT.80100887  DT.100703156  DT.100703187  DT.100703192  DT.100703154  DT.95306034  DT.121296613  DT.100703190 
    DT.100703180  DT.91842245  DT.91812692  DT.95200505  DT.100703164  DT.100703183  DT.91815578  DT.121296619 
    DT.121296696  DT.121296525  DT.121296701  DT.91842208  DT.100703157  DT.100703170  DT.100703167  DT.101988003 

    24/4000 AceView cDNA sequences (see all 4000):

    AA363309 BI258613 BM769109 BE545997 BF663366 BE396962 BQ639300 BM509113 
    AV711718 BM747273 N80936 BU856375 BM904114 BM763758 AA179203 BM772940 
    AW327663 AA379978 BM781976 AI051944 AA364392 BU553928 CA943058 BM781685 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for RPS4X (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b
    SP1:                          -     -                 -     -     -                                             
    SP2:                          -     -                 -     -     -                                             
    SP3:                          -     -                 -     -     -                                             
    SP4:                          -     -     -           -     -     -                                             
    SP5:                          -     -                 -                                                         


    ECgene alternative splicing isoforms for RPS4X

    Expression
    for RPS4X gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPS4X expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCAGATCTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See RPS4X Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPS4X

    SOURCE GeneReport for Unigene cluster: Hs.118076
        SABiosciences Custom PCR Arrays for RPS4X
    Primer
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    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RPS4X

    Orthologs
    for RPS4X gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPS4X gene from 9/40 species (see all 40)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RPS4X1 ribosomal protein S4, X-linked 83.9(n)
    98.48(a)    		   396001  NM_205108.1  NP_990439.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 99(a)
    		 1 → many
    		 GL343686.1(237406-240651)
    African clawed frog
    (Xenopus laevis)    		 Amphibia X64206.12   -- 85.71(n)    X64206.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii hmzehn21852 hmzehn2185 82.01(n)   337759  57052169 
    fruit fly
    (Drosophila melanogaster)    		 Insecta RpS41 , 3 protein biosynthesis structural constituent
    of ribosome less3
    Ribosomal protein S41    		 75(a)3
    69.24(n)1
    76.06(a)1    		   69F63
    394841  NM_079329.21  NP_524053.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y43B11AR.43
    rps-41    		 Protein RPS-41 64(a)3
    62(n)1
    64.98(a)1    		   IV(7083923-7084849)3
    1774811  NM_068702.31  NP_501103.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes RPS4A(YJR145C)4
    RPS4B1    		 Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; identical to Rps4Bp and has similarity to rat S4 ribosomal protein less4
    Rps4bp1    		 65.89(n)1
    73.15(a)1    		   10(703068-702027)4
    8566101  NP_012073.11  8536104 
     NP_012679.14 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT2G173601 40S ribosomal protein S4-1 63.47(n)
    70.11(a)    		   816243  NM_127291.3  NP_565414.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.84662 Oryza sativa (japonica cultivar-group) cDNA clone001-040-C06, full insert sequence less 76.69(n)    AK061826.1 


    ENSEMBL Gene Tree for RPS4X (if available)
    TreeFam Gene Tree for RPS4X (if available) 

    Paralogs
    for RPS4X gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPS4X gene
    RPS4Y22  RPS4XP212  RPS4Y12  
    3 SIMAP similar genes for RPS4X using alignment to 4 protein entries:     RS4X_HUMAN (see all proteins):
    RPS4Y1    RPS4Y2    RPS4XP21

    RPS4X for paralogs           About GeneDecksing


    5/22 Pseudogenes.org Pseudogenes for RPS4X (see all 22)
    PGOHUM00000238394 PGOHUM00000242288 PGOHUM00000242510 PGOHUM00000239291 PGOHUM00000239471


    Genomic Variants
    for RPS4X gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/113 NCBI SNPs in RPS4X are shown (see all 113)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1470403101,2
    		C,--65247112(+) GTCCAA/GGGAAC 1 -- ds50011Minor allele frequency- G:0.01NS 148
    rs1139699081,2
    		C,--65247454(+) CACTAA/GCTAAG 1 -- ds50012Minor allele frequency- G:0.02CSA NS 145
    rs1113545451,2
    		C--65247571(+) ACCAAT/AATGCT 1 -- ds50011Minor allele frequency- A:0.00CSA 1
    rs1139273161,2
    		C--65247572(+) CCAAAT/ATGCTA 1 -- ds50011Minor allele frequency- A:0.00CSA 1
    rs1479641901,2
    		C,--65248071(+) TCTGCA/GTGAGT 1 -- int10--------
    rs413061271,2
    		C,--65249139(+) CTCCAA/GTGTAA 1 -- int11Minor allele frequency- G:0.01NS 150
    rs1385097951,2
    		C,--65249153(+) CCACTC/TCAGTT 1 -- int10--------
    rs736242281,2
    		C,--65249792(+) GGGGGC/TCAATT 1 -- int12Minor allele frequency- T:0.02WA NS 150
    rs115454101,2
    		C--65250068(-) GACACC/AAAGGG 2 /T syn1 ese31Minor allele frequency- A:0.00NA 4542
    rs736242291,2
    		C,--65250179(+) CCGAGT/CAACAA 1 -- int11Minor allele frequency- C:0.00WA 2

    HapMap Linkage Disequilibrium report for RPS4X (71475529 - 71497150 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for RPS4X
         1 CNV: 96754
    Locus Specific Mutation Databases (LSDB): RPS4X

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPS4X
    DNA2.0 Custom Variant and Variant Library Synthesis for RPS4X

    Disorders / Diseases
    for RPS4X gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RPS4X for disorders           About GeneDecksing

    OMIM gene information: 312760    OMIM disorders: --

    12 diseases for RPS4X:    About MalaCards
    turner syndrome    x inactivation    stevens-johnson syndrome    band keratopathy
    wiskott-aldrich syndrome    cardiac tamponade    treacher collins syndrome    keratopathy
    fanconi's anemia    anemia    breast cancer    malaria

    1 disease from the University of Copenhagen DISEASES database for RPS4X:
    Turner syndrome

    2 Novoseek disease relationships for RPS4X gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    turners syndrome 82.2 3 1587534 (2), 8557258 (1)
    monosomy 78.2 3 8808278 (2)


    Export disorders for RPS4X gene to outside databases

    Publications
    for RPS4X gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPS4X gene, integrated from 9 sources (see all 64):
    (articles sorted by number of sources associating them with RPS4X)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the human gene, CCG2, that complements the BHK- derived temperature-sensitive cell cycle mutant tsBN63: identity of CCG2 with the human X chromosomal SCAR/RPS4X gene. (PubMed id 1795030)1, 2, 3, 9 Watanabe M.... Nishimoto T. (1991)
    2. Homologous ribosomal protein genes on the human X and Y chromosomes: escape from X inactivation and possible implications for Turner syndrome. (PubMed id 2124517)1, 2, 9 Fisher E.M.C.... Page D.C. (1990)
    3. Structure and function of ribosomal protein S4 genes on the human and mouse sex chromosomes. (PubMed id 8139551)1, 3, 9 Zinn A.R....Page D.C. (1994)
    4. Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)1, 2 Joeson L.... Nielsen F.C. (2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699)1, 2 Vladimirov S.N.... Otto A. (1996)
    7. Isolation of an abundantly expressed sequence from the human X chromosome by differential screening. (PubMed id 2829364)1, 2 Wiles M.V.... Goodfellow P.N. (1988)
    8. Ullrich-Turner syndrome is not caused by haploinsufficiency of RPS4X. (PubMed id 8557258)1, 9 Geerkens C....Vogel W. (1996)
    9. Relationship between the monosomy X phenotype and Y-linked ribosomal protein S4 (Rps4) in several species of mammals: a molecular evolutionary analysis of Rps4 homologs. (PubMed id 8808278)1, 9 Omoe K. and Endo A. (1996)
    10. Functional equivalence of human X- and Y-encoded isoforms of ribosomal protein S4 consistent with a role in Turner syndrome. (PubMed id 8358435)1, 9 Watanabe M....Nishimoto T. (1993)

    External Searches for RPS4X gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RPS4X gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6191 HGNC: 10424 AceView: RPS4X Ensembl:ENSG00000198034 euGenes: HUgn6191
    ECgene: RPS4X Kegg: 6191 H-InvDB: RPS4X

    Other Databases showing RPS4X gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RPS4X gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPS4X Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RPS4X gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RPS4X gene:
    Search GeneIP for patents involving RPS4X

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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