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Aliases for RPS4X Gene

Aliases for RPS4X Gene

  • Ribosomal Protein S4, X-Linked 2 3 5
  • 40S Ribosomal Protein S4, X Isoform 2 3
  • Small Ribosomal Subunit Protein ES4 3 4
  • Single Copy Abundant MRNA Protein 3 4
  • Ribosomal Protein S4X Isoform 2 3
  • Single-Copy Abundant MRNA 2 3
  • Cell Cycle Gene 2 2 3
  • SCR10 3 4
  • RPS4 3 4
  • CCG2 3 4
  • SCAR 3 4
  • DXS306 3
  • S4 3

External Ids for RPS4X Gene

Previous GeneCards Identifiers for RPS4X Gene

  • GC0XM067219
  • GC0XM068727
  • GC0XM069725
  • GC0XM070359
  • GC0XM071275
  • GC0XM071408
  • GC0XM071475
  • GC0XM065247

Summaries for RPS4X Gene

Entrez Gene Summary for RPS4X Gene

  • Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ribosomal protein S4, a component of the 40S subunit. Ribosomal protein S4 is the only ribosomal protein known to be encoded by more than one gene, namely this gene and ribosomal protein S4, Y-linked (RPS4Y). The 2 isoforms encoded by these genes are not identical, but are functionally equivalent. Ribosomal protein S4 belongs to the S4E family of ribosomal proteins. This gene is not subject to X-inactivation. It has been suggested that haploinsufficiency of the ribosomal protein S4 genes plays a role in Turner syndrome; however, this hypothesis is controversial. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS4X Gene

RPS4X (Ribosomal Protein S4, X-Linked) is a Protein Coding gene. Diseases associated with RPS4X include Turner Syndrome. Among its related pathways are Viral mRNA Translation and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome. An important paralog of this gene is RPS4Y1.

Gene Wiki entry for RPS4X Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS4X Gene

Genomics for RPS4X Gene

Regulatory Elements for RPS4X Gene

Enhancers for RPS4X Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG072272 1.1 ENCODE 13.6 +2.4 2395 6.0 HDGF ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 RTL5 OGT LOC100420758 ERCC6L NAP1L2 PIN4 RPS4X TOMM20P4 LOC392489 NHSL2
GH0XG072267 0.8 ENCODE 0.4 +7.8 7821 3.0 SOX13 FOXA2 JUN ZNF140 ZNF384 CHD7 ZNF2 FOSL1 ZNF121 POLR2A RPS4X ERCC6L
GH0XG072257 0.8 ENCODE 0.4 +19.0 18986 0.9 FOXA2 NFIB SAP130 ZEB1 RARA TEAD3 GLIS2 ZBTB48 PATZ1 ZNF639 PIN4 RPS4X ERCC6L
GH0XG072271 0.5 ENCODE 0.4 +6.0 5995 0.2 ZNF362 POLR2A ZNF384 PRDM1 RPS4X ERCC6L
GH0XG072255 0.4 Ensembl 0.3 +21.8 21800 0.2 ZFHX2 ERCC6L RPS4X
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPS4X on UCSC Golden Path with GeneCards custom track

Promoters for RPS4X Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000247208 500 1600 HDGF FOXA2 ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for RPS4X Gene

Chromosome:
X
Start:
72,255,679 bp from pter
End:
72,277,300 bp from pter
Size:
21,622 bases
Orientation:
Minus strand

Genomic View for RPS4X Gene

Genes around RPS4X on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS4X Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS4X Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS4X Gene

Proteins for RPS4X Gene

  • Protein details for RPS4X Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62701-RS4X_HUMAN
    Recommended name:
    40S ribosomal protein S4, X isoform
    Protein Accession:
    P62701
    Secondary Accessions:
    • P12631
    • P12750
    • P27576
    • P55831
    • Q14727
    • Q6IPY4

    Protein attributes for RPS4X Gene

    Size:
    263 amino acids
    Molecular mass:
    29598 Da
    Quaternary structure:
    • Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.

    Three dimensional structures from OCA and Proteopedia for RPS4X Gene

neXtProt entry for RPS4X Gene

Post-translational modifications for RPS4X Gene

  • Ubiquitination at Lys94 and Lys134
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS4X Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPS4X Gene

Domains & Families for RPS4X Gene

Gene Families for RPS4X Gene

Graphical View of Domain Structure for InterPro Entry

P62701

UniProtKB/Swiss-Prot:

RS4X_HUMAN :
  • Belongs to the eukaryotic ribosomal protein eS4 family.
Family:
  • Belongs to the eukaryotic ribosomal protein eS4 family.
genes like me logo Genes that share domains with RPS4X: view

Function for RPS4X Gene

Molecular function for RPS4X Gene

GENATLAS Biochemistry:
40S ribosomal protein S4,29kDa,X-linked isoform,escaping inactivation

Gene Ontology (GO) - Molecular Function for RPS4X Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0003735 structural constituent of ribosome IMP 8358435
GO:0005515 protein binding IPI 24965446
GO:0019843 rRNA binding IEA --
genes like me logo Genes that share ontologies with RPS4X: view
genes like me logo Genes that share phenotypes with RPS4X: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS4X Gene

Localization for RPS4X Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS4X Gene

Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS4X gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 4
mitochondrion 2

Gene Ontology (GO) - Cellular Components for RPS4X Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome IDA 15883184
genes like me logo Genes that share ontologies with RPS4X: view

Pathways & Interactions for RPS4X Gene

SuperPathways for RPS4X Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
.56
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing in the nucleus and cytosol
5 HIV Life Cycle
.45
genes like me logo Genes that share pathways with RPS4X: view

Gene Ontology (GO) - Biological Process for RPS4X Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IMP 8358435
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPS4X: view

No data available for SIGNOR curated interactions for RPS4X Gene

Drugs & Compounds for RPS4X Gene

No Compound Related Data Available

Transcripts for RPS4X Gene

Unigene Clusters for RPS4X Gene

Ribosomal protein S4, X-linked:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS4X Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b
SP1: - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - -
SP6: - - - -
SP7: - -
SP8:
SP9:

Relevant External Links for RPS4X Gene

GeneLoc Exon Structure for
RPS4X
ECgene alternative splicing isoforms for
RPS4X

Expression for RPS4X Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPS4X Gene

Protein differential expression in normal tissues from HIPED for RPS4X Gene

This gene is overexpressed in Nasal epithelium (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPS4X Gene



Protein tissue co-expression partners for RPS4X Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS4X Gene:

RPS4X

SOURCE GeneReport for Unigene cluster for RPS4X Gene:

Hs.118076

Evidence on tissue expression from TISSUES for RPS4X Gene

  • Nervous system(5)
  • Liver(4.9)
  • Pancreas(4.9)
  • Intestine(4.8)
  • Lung(4.8)
  • Muscle(4.8)
  • Kidney(4.7)
  • Skin(4.7)
  • Eye(4.6)
  • Stomach(4.2)
  • Blood(4.1)
  • Heart(3.6)
  • Bone(3.5)
  • Spleen(3.1)
  • Lymph node(2.6)
  • Bone marrow(2.5)
  • Thyroid gland(2.5)
  • Adrenal gland(2.4)
  • Gall bladder(2.3)
genes like me logo Genes that share expression patterns with RPS4X: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS4X Gene

Orthologs for RPS4X Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS4X Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPS4 35
  • 100 (a)
OneToMany
RPS4Y1 35
  • 99 (a)
OneToMany
-- 35
  • 98 (a)
OneToMany
RPS4X 34
  • 90.24 (n)
dog
(Canis familiaris)
Mammalia RPS4 35
  • 100 (a)
OneToOne
LOC102154781 34
  • 90.49 (n)
mouse
(Mus musculus)
Mammalia Rps4x 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPS4X 34 35
  • 99.87 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RPS4X 35
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RPS4X 35
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPS4 35
  • 98 (a)
OneToOne
RPS4X 34
  • 83.9 (n)
lizard
(Anolis carolinensis)
Reptilia RPS4X 35
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rps4x 34
  • 83.78 (n)
zebrafish
(Danio rerio)
Actinopterygii rps4x 34 35
  • 83.33 (n)
hmzehn2185 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11979 34
fruit fly
(Drosophila melanogaster)
Insecta RpS4 36 34 35
  • 69.24 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006871 34
  • 64.89 (n)
worm
(Caenorhabditis elegans)
Secernentea Y43B11AR.4 36
  • 64 (a)
rps-4 34 35
  • 62.02 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS4A 35 37
  • 72 (a)
ManyToMany
RPS4B 34 35
  • 65.64 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL391C 34
  • 66.92 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B03652g 34
  • 65.89 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G17360 34
  • 63.47 (n)
rice
(Oryza sativa)
Liliopsida Os05g0368300 34
  • 64.2 (n)
Os.8466 34
barley
(Hordeum vulgare)
Liliopsida Hv.8478 34
wheat
(Triticum aestivum)
Liliopsida Ta.1924 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5094 35
  • 76 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU02181 34
  • 68.88 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps403 34
  • 65.12 (n)
Species where no ortholog for RPS4X was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPS4X Gene

ENSEMBL:
Gene Tree for RPS4X (if available)
TreeFam:
Gene Tree for RPS4X (if available)

Paralogs for RPS4X Gene

Variants for RPS4X Gene

Sequence variations from dbSNP and Humsavar for RPS4X Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000214249 -- 72,276,733(+) TGACA(A/C)CAATT intron-variant
rs1000554984 -- 72,278,199(+) AGGGA(A/G)CAGGT upstream-variant-2KB
rs1000646820 -- 72,277,881(+) GTATA(A/T)AATCA upstream-variant-2KB
rs1000825369 -- 72,273,162(+) TGGAT(A/G)CTACA intron-variant
rs1001101562 -- 72,272,851(+) TCACC(-/TCACT)TAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPS4X Gene

Variant ID Type Subtype PubMed ID
esv2740221 CNV deletion 23290073
esv2740222 CNV deletion 23290073

Variation tolerance for RPS4X Gene

Residual Variation Intolerance Score: 31.1% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS4X Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPS4X

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS4X Gene

Disorders for RPS4X Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPS4X Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
turner syndrome
  • gonadal dysgenesis
- elite association - COSMIC cancer census association via MalaCards
Search RPS4X in MalaCards View complete list of genes associated with diseases

Relevant External Links for RPS4X

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPS4X
genes like me logo Genes that share disorders with RPS4X: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS4X Gene

Publications for RPS4X Gene

  1. Molecular cloning of the human gene, CCG2, that complements the BHK- derived temperature-sensitive cell cycle mutant tsBN63: identity of CCG2 with the human X chromosomal SCAR/RPS4X gene. (PMID: 1795030) Watanabe M. … Nishimoto T. (J. Cell Sci. 1991) 2 3 4 22 64
  2. Structure and function of ribosomal protein S4 genes on the human and mouse sex chromosomes. (PMID: 8139551) Zinn A.R. … Page D.C. (Mol. Cell. Biol. 1994) 2 3 22 64
  3. Homologous ribosomal protein genes on the human X and Y chromosomes: escape from X inactivation and possible implications for Turner syndrome. (PMID: 2124517) Fisher E.M.C. … Page D.C. (Cell 1990) 3 4 22 64
  4. Molecular composition of IMP1 ribonucleoprotein granules. (PMID: 17289661) Joeson L. … Nielsen F.C. (Mol. Cell. Proteomics 2007) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for RPS4X Gene

Sources for RPS4X Gene

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