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Aliases for RPS4X Gene

Aliases for RPS4X Gene

  • Ribosomal Protein S4, X-Linked 2 3
  • Single Copy Abundant MRNA Protein 3 4
  • Ribosomal Protein S4X Isoform 2 3
  • Single-Copy Abundant MRNA 2 3
  • Cell Cycle Gene 2 2 3
  • SCR10 3 4
  • RPS4 3 4
  • CCG2 3 4
  • SCAR 3 4
  • 40S Ribosomal Protein S4 2
  • X Isoform 2
  • DXS306 3
  • S4 3

External Ids for RPS4X Gene

Previous GeneCards Identifiers for RPS4X Gene

  • GC0XM067219
  • GC0XM068727
  • GC0XM069725
  • GC0XM070359
  • GC0XM071275
  • GC0XM071408
  • GC0XM071475
  • GC0XM065247

Summaries for RPS4X Gene

Entrez Gene Summary for RPS4X Gene

  • Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ribosomal protein S4, a component of the 40S subunit. Ribosomal protein S4 is the only ribosomal protein known to be encoded by more than one gene, namely this gene and ribosomal protein S4, Y-linked (RPS4Y). The 2 isoforms encoded by these genes are not identical, but are functionally equivalent. Ribosomal protein S4 belongs to the S4E family of ribosomal proteins. This gene is not subject to X-inactivation. It has been suggested that haploinsufficiency of the ribosomal protein S4 genes plays a role in Turner syndrome; however, this hypothesis is controversial. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS4X Gene

RPS4X (Ribosomal Protein S4, X-Linked) is a Protein Coding gene. Diseases associated with RPS4X include turner syndrome. Among its related pathways are Infectious disease and Transport to the Golgi and subsequent modification. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome. An important paralog of this gene is RPS4Y1.

Gene Wiki entry for RPS4X Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS4X Gene

Genomics for RPS4X Gene

Regulatory Elements for RPS4X Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RPS4X Gene

72,255,679 bp from pter
72,277,300 bp from pter
21,622 bases
Minus strand

Genomic View for RPS4X Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for RPS4X Gene

Proteins for RPS4X Gene

  • Protein details for RPS4X Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    40S ribosomal protein S4, X isoform
    Protein Accession:
    Secondary Accessions:
    • P12631
    • P12750
    • P27576
    • P55831
    • Q14727
    • Q6IPY4

    Protein attributes for RPS4X Gene

    263 amino acids
    Molecular mass:
    29598 Da
    Quaternary structure:
    • Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.

    Three dimensional structures from OCA and Proteopedia for RPS4X Gene

neXtProt entry for RPS4X Gene

Proteomics data for RPS4X Gene at MOPED

Post-translational modifications for RPS4X Gene

  • Ubiquitination at Lys 94 and Lys 134
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS4X Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RPS4X Gene

Domains & Families for RPS4X Gene

Gene Families for RPS4X Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 S4 RNA-binding domain.
  • Belongs to the ribosomal protein S4e family.
  • Contains 1 S4 RNA-binding domain.
  • Belongs to the ribosomal protein S4e family.
genes like me logo Genes that share domains with RPS4X: view

Function for RPS4X Gene

Molecular function for RPS4X Gene

GENATLAS Biochemistry:
40S ribosomal protein S4,29kDa,X-linked isoform,escaping inactivation

Gene Ontology (GO) - Molecular Function for RPS4X Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding --
GO:0003735 structural constituent of ribosome IMP 8358435
GO:0019843 rRNA binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPS4X: view
genes like me logo Genes that share phenotypes with RPS4X: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPS4X

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS4X Gene

Localization for RPS4X Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS4X Gene

Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Subcellular locations from

Jensen Localization Image for RPS4X Gene COMPARTMENTS Subcellular localization image for RPS4X gene
Compartment Confidence
cytosol 5
extracellular 5

Gene Ontology (GO) - Cellular Components for RPS4X Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
GO:0005840 ribosome IDA 15883184
GO:0005844 polysome IDA 8139551
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with RPS4X: view

Pathways & Interactions for RPS4X Gene

SuperPathways for RPS4X Gene

genes like me logo Genes that share pathways with RPS4X: view

Pathways by source for RPS4X Gene

1 BioSystems pathway for RPS4X Gene
1 KEGG pathway for RPS4X Gene
1 GeneGo (Thomson Reuters) pathway for RPS4X Gene

Gene Ontology (GO) - Biological Process for RPS4X Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
GO:0006415 translational termination TAS --
genes like me logo Genes that share ontologies with RPS4X: view

No data available for SIGNOR curated interactions for RPS4X Gene

Drugs & Compounds for RPS4X Gene

No Compound Related Data Available

Transcripts for RPS4X Gene

Unigene Clusters for RPS4X Gene

Ribosomal protein S4, X-linked:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPS4X

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS4X Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b
SP1: - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - -
SP6: - - - -
SP7: - -

Relevant External Links for RPS4X Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS4X Gene

mRNA expression in normal human tissues for RPS4X Gene

Protein differential expression in normal tissues from HIPED for RPS4X Gene

This gene is overexpressed in Nasal epithelium (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS4X Gene

SOURCE GeneReport for Unigene cluster for RPS4X Gene Hs.118076

genes like me logo Genes that share expression patterns with RPS4X: view

Protein tissue co-expression partners for RPS4X Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS4X Gene

Orthologs for RPS4X Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS4X Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPS4X 35
  • 90.24 (n)
  • 100 (a)
-- 36
  • 98 (a)
RPS4 36
  • 100 (a)
RPS4Y1 36
  • 99 (a)
(Canis familiaris)
Mammalia LOC102154781 35
  • 90.49 (n)
  • 94.68 (a)
RPS4 36
  • 100 (a)
(Pan troglodytes)
Mammalia RPS4X 35
  • 99.87 (n)
  • 100 (a)
RPS4X 36
  • 100 (a)
(Mus musculus)
Mammalia Rps4x 16
Rps4x 36
  • 100 (a)
(Monodelphis domestica)
Mammalia RPS4X 36
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia RPS4X 36
  • 97 (a)
(Gallus gallus)
Aves RPS4X 35
  • 83.9 (n)
  • 98.48 (a)
RPS4 36
  • 98 (a)
(Anolis carolinensis)
Reptilia RPS4X 36
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rps4x 35
  • 83.78 (n)
  • 97.72 (a)
(Danio rerio)
Actinopterygii hmzehn2185 35
rps4x 35
  • 83.33 (n)
  • 93.51 (a)
rps4x 36
  • 93 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11979 35
fruit fly
(Drosophila melanogaster)
Insecta RpS4 37
  • 75 (a)
RpS4 35
  • 69.24 (n)
  • 76.06 (a)
RpS4 36
  • 75 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006871 35
  • 64.89 (n)
  • 70.61 (a)
(Caenorhabditis elegans)
Secernentea Y43B11AR.4 37
  • 64 (a)
rps-4 35
  • 62.02 (n)
  • 64.73 (a)
rps-4 36
  • 64 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL391C 35
  • 66.92 (n)
  • 73.75 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B03652g 35
  • 65.89 (n)
  • 73.15 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS4B 35
  • 65.64 (n)
  • 72.59 (a)
RPS4A 36
  • 72 (a)
RPS4B 36
  • 72 (a)
RPS4A 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G17360 35
  • 63.47 (n)
  • 70.11 (a)
(Hordeum vulgare)
Liliopsida Hv.8478 35
(Oryza sativa)
Liliopsida Os.8466 35
Os05g0368300 35
  • 64.2 (n)
  • 70.82 (a)
(Triticum aestivum)
Liliopsida Ta.1924 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02181 35
  • 68.88 (n)
  • 75 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps403 35
  • 65.12 (n)
  • 72.2 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5094 36
  • 76 (a)
Species with no ortholog for RPS4X:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPS4X Gene

Gene Tree for RPS4X (if available)
Gene Tree for RPS4X (if available)

Paralogs for RPS4X Gene

Paralogs for RPS4X Gene

(2) SIMAP similar genes for RPS4X Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RPS4X: view

Variants for RPS4X Gene

Sequence variations from dbSNP and Humsavar for RPS4X Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs7580 -- 72,273,841(-) GATTT(A/G)GAGAC synonymous-codon, reference
rs10783 -- 72,272,730(-) GTATC(A/C)GCCTC missense, reference
rs12564 -- 72,272,656(-) CTGGG(C/T)GACAT utr-variant-3-prime
rs14285 -- 72,275,552(-) TGCTG(G/T)ATTCA reference, missense
rs1804389 -- 72,273,377(-) GTGTA(C/T)GGTGA missense, reference

Structural Variations from Database of Genomic Variants (DGV) for RPS4X Gene

Variant ID Type Subtype PubMed ID
esv2740221 CNV Deletion 23290073
esv2740222 CNV Deletion 23290073

Variation tolerance for RPS4X Gene

Residual Variation Intolerance Score: 31.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS4X Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS4X Gene

Disorders for RPS4X Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPS4X Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
turner syndrome
  • gonadal dysgenesis - turner
- elite association
Search RPS4X in MalaCards View complete list of genes associated with diseases

Relevant External Links for RPS4X

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RPS4X: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS4X Gene

Publications for RPS4X Gene

  1. Structure and function of ribosomal protein S4 genes on the human and mouse sex chromosomes. (PMID: 8139551) Zinn A.R. … Page D.C. (Mol. Cell. Biol. 1994) 2 23 67
  2. Molecular cloning of the human gene, CCG2, that complements the BHK- derived temperature-sensitive cell cycle mutant tsBN63: identity of CCG2 with the human X chromosomal SCAR/RPS4X gene. (PMID: 1795030) Watanabe M. … Nishimoto T. (J. Cell Sci. 1991) 2 23 67
  3. Establishment of a new method for precisely determining the functions of individual mitochondrial genes, using Dictyostelium cells. (PMID: 18366713) Chida J. … Maeda Y. (BMC Genet. 2008) 23 67
  4. RPS4Y gene family evolution in primates. (PMID: 18477388) AndrAcs O. … Bosch M. (BMC Evol. Biol. 2008) 23 67
  5. Screening for metronidazole-resistance associated gene fragments of H pylori by suppression subtractive hybridization. (PMID: 17465479) Li A.Q. … Zhu Y.L. (World J. Gastroenterol. 2007) 23 67

Products for RPS4X Gene

Sources for RPS4X Gene

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