Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPS4X Gene

protein-coding   GIFtS: 62
GCID: GC0XM071475

Ribosomal Protein S4, X-Linked

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ribosomal Protein S4, X-Linked1 2     RPS42 3
CCG22 3 5     SCR102 3
SCAR2 3 5     40S Ribosomal Protein S41
Cell Cycle Gene 21 2     X Isoform1
Ribosomal Protein S4X Isoform1 2     40S Ribosomal Protein S4, X Isoform2
Single-Copy Abundant MRNA1 2     DXS3062
Single Copy Abundant MRNA Protein2 3     S42

External Ids:    HGNC: 104241   Entrez Gene: 61912   Ensembl: ENSG000001980347   OMIM: 3127605   UniProtKB: P627013   

Export aliases for RPS4X gene to outside databases

Previous GC identifers: GC0XM067219 GC0XM068727 GC0XM069725 GC0XM070359 GC0XM071275 GC0XM071408 GC0XM065247


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RPS4X Gene:
Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S
subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct
proteins. This gene encodes ribosomal protein S4, a component of the 40S subunit. Ribosomal protein S4 is the
only ribosomal protein known to be encoded by more than one gene, namely this gene and ribosomal protein S4,
Y-linked (RPS4Y). The 2 isoforms encoded by these genes are not identical, but are functionally equivalent.
Ribosomal protein S4 belongs to the S4E family of ribosomal proteins. This gene is not subject to X-inactivation.
It has been suggested that haploinsufficiency of the ribosomal protein S4 genes plays a role in Turner syndrome;
however, this hypothesis is controversial. As is typical for genes encoding ribosomal proteins, there are
multiple processed pseudogenes of this gene dispersed through the genome. (provided by RefSeq, Jul 2008)

GeneCards Summary for RPS4X Gene: 
RPS4X (ribosomal protein S4, X-linked) is a protein-coding gene. Diseases associated with RPS4X include band keratopathy, and cardiac tamponade, and among its related super-pathways are Eukaryotic Translation Initiation and Formation of the ternary complex, and subsequently, the 43S complex. GO annotations related to this gene include structural constituent of ribosome and rRNA binding. An important paralog of this gene is RPS4Y2.

Gene Wiki entry for RPS4X Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_011669.17  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPS4X gene promoter:
         Oct-B1   Pax-5   p53   CUTL1   FAC1   NRF-2   POU2F1   POU2F1a   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPS4X promoter sequence
   Search SABiosciences Chromatin IP Primers for RPS4X

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS4X


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq13.1   Ensembl cytogenetic band:  Xq13.1   HGNC cytogenetic band: Xq13.1

RPS4X Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS4X gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM071475:  view genomic region     (about GC identifiers)

Start:
71,475,529 bp from pter      End:
71,497,150 bp from pter
Size:
21,622 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RS4X_HUMAN, P62701 (See protein sequence)
Recommended Name: 40S ribosomal protein S4, X isoform  
Size: 263 amino acids; 29598 Da
Subunit: Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1,
HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1,
RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs
Subcellular location: Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs
1 PDB 3D structure from and Proteopedia for RPS4X:
3J3A (3D)    
Secondary accessions: P12631 P12750 P27576 P55831 Q14727 Q6IPY4

Explore the universe of human proteins at neXtProt for RPS4X: NX_P62701

Explore proteomics data for RPS4X at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P62701

  • RPS4X Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RPS4X Protein Expression
    REFSEQ proteins: NP_000998.1  
    ENSEMBL proteins: 
     ENSP00000362744   ENSP00000362729  
    Reactome Protein details: P62701
    Human Recombinant Protein Products for RPS4X: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for RPS4X
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for RPS4X
    GenScript Custom Purified and Recombinant Proteins Services for RPS4X
    Novus Biologicals RPS4X Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RPS4X 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--
    GO:0005840ribosome IDA15883184
    GO:0005844polysome IDA8139551
    GO:0015935small ribosomal subunit IDA8139551

    RPS4X for ontologies           About GeneDecksing



    RPS4X Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for RPS4X
    OriGene Custom Antibody Services for RPS4X
    GenScript Custom Superior Antibodies Services for RPS4X
    Novus Biologicals RPS4X Antibodies
    Abcam antibodies for RPS4X
    Cloud-Clone Corp. Antibodies for RPS4X 
    ThermoFisher Antibodies for RPS4X
    LSBio Antibodies in human, mouse, rat for RPS4X 

    Assay Products for RPS4X: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RPS4X
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RPS4X
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RPS4X 
    Cloud-Clone Corp. CLIAs for RPS4X


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RPS: S ribosomal proteins

    5/6 InterPro protein domains (see all 6):
     IPR013845 Ribosomal_S4e_central_region
     IPR002942 S4_RNA-bd
     IPR013843 Ribosomal_S4e_N
     IPR000876 Ribosomal_S4e
     IPR018199 Ribosomal_S4e_N_CS

    Graphical View of Domain Structure for InterPro Entry P62701

    ProtoNet protein and cluster: P62701

    2 Blocks protein domains:
    IPB000876 Ribosomal protein S4E
    IPB002942 RNA-binding S4


    UniProtKB/Swiss-Prot: RS4X_HUMAN, P62701
    Similarity: Belongs to the ribosomal protein S4e family
    Similarity: Contains 1 S4 RNA-binding domain


    RPS4X for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for RPS4X:
    40S ribosomal protein S4,29kDa,X-linked isoform,escaping inactivation

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding ----
    GO:0003735structural constituent of ribosome IMP8358435
    GO:0019843rRNA binding IEA--
         
    RPS4X for ontologies           About GeneDecksing


    Phenotypes:
         10 GenomeRNAi human phenotypes for RPS4X:
     Decreased Hepatitis C virus re  Decreased homologous recombina  Decreased viability  Decreased viability of wild-ty 
     Increased S DNA content  Increased circadian period len  Increased gamma-H2AX phosphory  Nucleolar pre-40S maturation d 
     S arrest  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RPS4X 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RPS4X

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RPS4X 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RPS4X 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPS4X
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate RPS4X
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RPS4X
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS4X

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RPS4X
    Sirion Biotech Customized adenovirus for overexpression of RPS4X

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RPS4X (see all 9)
    OriGene ORF clones in mouse, rat for RPS4X
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RPS4X (NM_001007)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPS4X
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS4X
    Sirion Biotech Customized lentivirus for stable overexpression of RPS4X 
                         Customized lentivirus expression plasmids for stable overexpression of RPS4X 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RPS4X
    Search LifeMap BioReagents cell lines for RPS4X
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS4X


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RPS4X About   (see all 6)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Viral mRNA Translation
    Influenza Life Cycle0.95
    3' -UTR-mediated translational regulation0.93
    Influenza Infection0.95
    L13a-mediated translational silencing of Ceruloplasmin expression0.93
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Formation of a pool of free 40S subunits0.90
    Eukaryotic Translation Termination0.94
    Nonsense-Mediated Decay0.84
    2Translation initiation complex formation
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.95
    Formation of the ternary complex, and subsequently, the 43S complex0.87
    Ribosomal scanning and start codon recognition0.95
    Translation initiation complex formation0.87
    3Metabolism of mRNA
    Metabolism of mRNA0.92
    Metabolism of RNA0.92
    4Generic Transcription Pathway
    Gene Expression0.47
    5Asparagine N-linked glycosylation
    Metabolism of proteins0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPS4X
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPS4X
        Cytoplasmic Ribosomal Proteins

    5/27        Reactome Pathways for RPS4X (see all 27)
        Formation of the ternary complex, and subsequently, the 43S complex
    Nonsense Mediated Decay Independent of the Exon Junction Complex
    Nonsense-Mediated Decay
    Translation
    SRP-dependent cotranslational protein targeting to membrane


    1         Kegg Pathway  (Kegg details for RPS4X):
        Ribosome


    RPS4X for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RPS4X

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/560 Interacting proteins for RPS4X (P627012, 3 ENSP000003627444) via UniProtKB, MINT, STRING, and/or I2D (see all 560)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=2 
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    HIST1H4EP628053I2D: score=2 
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--
    GO:0006415translational termination TAS--

    RPS4X for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RPS4X (RS4X)

    Search CenterWatch for drugs/clinical trials and news about RPS4X / RS4X

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RPS4X gene: 
    NM_001007.4  

    Unigene Cluster for RPS4X:

    Ribosomal protein S4, X-linked
    Hs.118076  [show with all ESTs]
    Unigene Representative Sequence: AK097914
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000470671 ENST00000492695 ENST00000316084(uc004ear.3) ENST00000486733(uc011mqb.2)
    ENST00000373626
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPS4X
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate RPS4X
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RPS4X
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS4X
    Clone
    Products:
         
    OriGene clones in human, mouse for RPS4X (see all 9)
    OriGene ORF clones in mouse, rat for RPS4X
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RPS4X (NM_001007)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPS4X
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS4X
    Sirion Biotech Customized lentivirus for stable overexpression of RPS4X 
                         Customized lentivirus expression plasmids for stable overexpression of RPS4X 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RPS4X
    OriGene qSTAR qPCR primer pairs in human, mouse for RPS4X
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RPS4X
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS4X
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS4X

    Additional mRNA sequence: 

    AK097914.1 AK222479.1 AK293663.1 AK311745.1 BC000472.2 BC002569.1 BC007308.1 BC071662.1 
    BC100903.1 BC100904.1 CR456735.1 M22146.1 M58458.1 Z70767.1 

    24/106 DOTS entries (see all 106):

    DT.80100887  DT.100703156  DT.100703187  DT.100703192  DT.100703154  DT.95306034  DT.121296613  DT.100703190 
    DT.100703180  DT.91842245  DT.91812692  DT.95200505  DT.100703164  DT.100703183  DT.91815578  DT.121296619 
    DT.121296525  DT.121296696  DT.121296701  DT.91842208  DT.100703157  DT.100703170  DT.100703167  DT.101988003 

    24/4000 AceView cDNA sequences (see all 4000):

    BU069476 CA448289 AV713946 BU071392 BQ926800 BM509093 CB128186 BM810091 
    BM773060 BM091345 BQ670898 BI256526 BE379032 BM842792 BU735054 BQ268689 
    BM764700 AI708357 AA331983 BE378882 BM772778 BM887620 CF126218 AW248615 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for RPS4X (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b
    SP1:                          -     -                 -     -     -                                             
    SP2:                          -     -                 -     -     -                                             
    SP3:                          -     -                 -     -     -                                             
    SP4:                          -     -     -           -     -     -                                             
    SP5:                          -     -                 -                                                         


    ECgene alternative splicing isoforms for RPS4X

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPS4X expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGATCTTT
    RPS4X Expression
    About this image


    See RPS4X Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPS4X

    SOURCE GeneReport for Unigene cluster: Hs.118076
        SABiosciences Custom PCR Arrays for RPS4X
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RPS4X
    OriGene qSTAR qPCR primer pairs in human, mouse for RPS4X
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RPS4X
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS4X
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS4X
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS4X

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPS4X gene from 10/29 species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rps4x1 , 5 ribosomal protein S4, X-linked1, 5 91(n)1
    100(a)1
      X (45.20 cM)5
    201021  NM_009094.11  NP_033120.11 
     1021849415 
    chicken
    (Gallus gallus)
    Aves RPS4X1 ribosomal protein S4, X-linked 83.9(n)
    98.48(a)
      396001  NM_205108.1  NP_990439.1 
    lizard
    (Anolis carolinensis)
    Reptilia RPS4X6
    ribosomal protein S4, X-linked
    99(a)
    1 ↔ 1
    GL343686.1(237404-240652)
    African clawed frog
    (Xenopus laevis)
    Amphibia X64206.12   -- 85.71(n)    X64206.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hmzehn21852 hmzehn2185 82.01(n)   337759  57052169 
    fruit fly
    (Drosophila melanogaster)
    Insecta RpS41 , 3 protein biosynthesis structural
    constituent of more3
    Ribosomal protein S41
    75(a)3
    69.24(n)1
    76.06(a)1
      69F63
    394841  NM_079329.21  NP_524053.21 
    worm
    (Caenorhabditis elegans)
    Secernentea Y43B11AR.43
    rps-41
    Protein RPS-41 64(a)3
    62(n)1
    64.98(a)1
      IV(7083923-7084849)3
    1774811  NM_068702.31  NP_501103.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPS4A(YJR145C)4
    RPS4B1
    Protein component of the small (40S) ribosomal subunit; more4
    Rps4bp1
    65.89(n)1
    73.15(a)1
      10(703068-702027)4
    8566101  NP_012073.11  8536104 
     NP_012679.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G173601 40S ribosomal protein S4-1 63.47(n)
    70.11(a)
      816243  NM_127291.3  NP_565414.1 
    rice
    (Oryza sativa)
    Liliopsida Os.84662 Oryza sativa (japonica cultivar-group) cDNA clone0 more 76.69(n)    AK061826.1 


    ENSEMBL Gene Tree for RPS4X (if available)
    TreeFam Gene Tree for RPS4X (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPS4X gene
    RPS4Y22  RPS4Y12  
    3 SIMAP similar genes for RPS4X using alignment to 4 protein entries:     RS4X_HUMAN (see all proteins):
    RPS4Y1    RPS4Y2    RPS4XP21

    RPS4X for paralogs           About GeneDecksing


    5/22 Pseudogenes.org Pseudogenes for RPS4X (see all 22)
    PGOHUM00000238394 PGOHUM00000242288 PGOHUM00000242510 PGOHUM00000239291 PGOHUM00000239471


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/151 SNPs in RPS4X are shown (see all 151)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs345639811,2
    C--65250508(+) AACTT-/AC    
       T
    /CTA
    CTTAC
    2 -- cds13CSA 6
    rs1127658121,2
    C--65250508(+) AAACTA/TCTTAC 1 -- int10--------
    rs38424721,2
    C,F--71495390(+) CTTCTACT/-TACCC 1 -- cds11Minor allele frequency- -:0.08NS 144
    rs1470403101,2
    C--71497578(+) GTCCAA/GGGAAC 1 -- ds50011Minor allele frequency- G:0.01NS 148
    rs1393292631,2
    --71497615(+) CATTTA/GTGACC 1 -- ds50010--------
    rs456246421,2
    C,F--71497832(+) GAGATA/CAATAC 1 -- ds50011Minor allele frequency- C:0.03NS 144
    rs1472329791,2
    --71497840(+) TACTCC/TGGGAT 1 -- ds50010--------
    rs1864923911,2
    --71497841(+) ACTCCA/GGGATT 1 -- ds50010--------
    rs1139699081,2
    C--71497920(+) CACTAA/GCTAAG 1 -- ds50012Minor allele frequency- G:0.02CSA NS 145
    rs1917734471,2
    --71497995(+) AAATAG/TCAGGA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for RPS4X (71475529 - 71497150 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RPS4X:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2740222CNV Deletion23290073
    esv2740221CNV Deletion23290073


    Locus Specific Mutation Databases (LSDB): RPS4X
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RPS4X
    DNA2.0 Custom Variant and Variant Library Synthesis for RPS4X

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 312760    OMIM disorders: --

    10 diseases for RPS4X:    About MalaCards
    band keratopathy    cardiac tamponade    turner syndrome    keratopathy
    stevens-johnson syndrome    wiskott-aldrich syndrome    fanconi's anemia    anemia
    influenza    breast cancer

    1 disease from the University of Copenhagen DISEASES database for RPS4X:
    Turner syndrome

    RPS4X for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for RPS4X gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    turners syndrome 82.2 3 1587534 (2), 8557258 (1)
    monosomy 78.2 3 8808278 (2)


    Export disorders for RPS4X gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPS4X gene, integrated from 9 sources (see all 79):
    (articles sorted by number of sources associating them with RPS4X)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the human gene, CCG2, that complements the BHK- derived temperature-sensitive cell cycle mutant tsBN63: identity of CCG2 with the human X chromosomal SCAR/RPS4X gene. (PubMed id 1795030)1, 2, 3, 9 Watanabe M.... Nishimoto T. (1991)
    2. Homologous ribosomal protein genes on the human X and Y chromosomes: escape from X inactivation and possible implications for Turner syndrome. (PubMed id 2124517)1, 2, 9 Fisher E.M.C.... Page D.C. (1990)
    3. Structure and function of ribosomal protein S4 genes on the human and mouse sex chromosomes. (PubMed id 8139551)1, 3, 9 Zinn A.R....Page D.C. (1994)
    4. Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)1, 2 Joeson L.... Nielsen F.C. (2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699)1, 2 Vladimirov S.N.... Otto A. (1996)
    7. Isolation of an abundantly expressed sequence from the human X chromosome by differential screening. (PubMed id 2829364)1, 2 Wiles M.V.... Goodfellow P.N. (1988)
    8. Ullrich-Turner syndrome is not caused by haploinsufficiency of RPS4X. (PubMed id 8557258)1, 9 Geerkens C....Vogel W. (1996)
    9. Relationship between the monosomy X phenotype and Y-linked ribosomal protein S4 (Rps4) in several species of mammals: a molecular evolutionary analysis of Rps4 homologs. (PubMed id 8808278)1, 9 Omoe K. and Endo A. (1996)
    10. Functional equivalence of human X- and Y-encoded isoforms of ribosomal protein S4 consistent with a role in Turner syndrome. (PubMed id 8358435)1, 9 Watanabe M....Nishimoto T. (1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6191 HGNC: 10424 AceView: RPS4X Ensembl:ENSG00000198034 euGenes: HUgn6191
    ECgene: RPS4X Kegg: 6191 H-InvDB: RPS4X

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPS4X Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RPS4X gene:
    Search GeneIP for patents involving RPS4X

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RPS4X   OriGene RNAi products in human, mouse, rat for RPS4X  
     OriGene qPCR primer pairs and template standards for RPS4X   OriGene Protein Over-expression Lysate for RPS4X  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for RPS4X  
     OriGene qSTAR qPCR primer pairs in human, mouse for RPS4X   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for RPS4X   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RPS4X   OriGene Custom Protein Services for RPS4X  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RPS4X
     QIAGEN SeqTarget long-range PCR primers for resequencing RPS4X
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS4X
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS4X
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS4X
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS4X
     GenScript Custom Purified and Recombinant Proteins Services for RPS4X GenScript cDNA clones with any tag delivered in your preferred vector for RPS4X
     GenScript Custom Assay Services for RPS4X GenScript Custom Superior Antibodies Services for RPS4X
     GenScript Custom overexpressing Cell Line Services for RPS4X CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RPS4X promoter
     Search Chromatin IP Primers for RPS4X
     RT2 qPCR Primer Assay in human, mouse / rat RPS4X
     GNC Network for RPS4X
     SABiosciences Custom PCR Arrays for RPS4X
     Search Tocris compounds for RPS4X (RS4X)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RPS4X antibodies
     RPS4X proteins
     Antibodies for RPS4X
     See all of Abcam's Antibodies, Kits and Proteins for RPS4X
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for RPS4X
     Antibodies for RPS4X
     ELISAs for RPS4X
     CLIAs for RPS4X
     Search LifeMap BioReagents cell lines for RPS4X
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS4X
     Browse SwitchGear 3'UTR luciferase reporter plasmids for RPS4X
     SwitchGear Promoter luciferase reporter plasmids for RPS4X
     ThermoFisher Antibodies for RPS4X
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS4X
     inGenious Targeting Laboratory - Custom generated mouse model solutions for RPS4X
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RPS4X
    Customized:
     lentivirus for stable overexpression of RPS4X
     lentivirus expression plasmids for stable overexpression of RPS4X
     adenovirus for overexpression of RPS4X
     LSBio Antibodies in human, mouse, rat for RPS4X
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RPS4X gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4