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RPS4X Gene

protein-coding   GIFtS: 63
GCID: GC0XM071475

Ribosomal Protein S4, X-Linked

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribosomal Protein S4, X-Linked1 2     RPS42 3
CCG22 3 5     SCR102 3
SCAR2 3 5     40S Ribosomal Protein S41
Cell Cycle Gene 21 2     X Isoform1
Ribosomal Protein S4X Isoform1 2     40S Ribosomal Protein S4, X Isoform2
Single-Copy Abundant MRNA1 2     DXS3062
Single Copy Abundant MRNA Protein2 3     S42

External Ids:    HGNC: 104241   Entrez Gene: 61912   Ensembl: ENSG000001980347   OMIM: 3127605   UniProtKB: P627013   

Export aliases for RPS4X gene to outside databases

Previous GC identifers: GC0XM067219 GC0XM068727 GC0XM069725 GC0XM070359 GC0XM071275 GC0XM071408 GC0XM065247


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RPS4X Gene:
Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S
subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct
proteins. This gene encodes ribosomal protein S4, a component of the 40S subunit. Ribosomal protein S4 is the
only ribosomal protein known to be encoded by more than one gene, namely this gene and ribosomal protein S4,
Y-linked (RPS4Y). The 2 isoforms encoded by these genes are not identical, but are functionally equivalent.
Ribosomal protein S4 belongs to the S4E family of ribosomal proteins. This gene is not subject to X-inactivation.
It has been suggested that haploinsufficiency of the ribosomal protein S4 genes plays a role in Turner syndrome;
however, this hypothesis is controversial. As is typical for genes encoding ribosomal proteins, there are
multiple processed pseudogenes of this gene dispersed through the genome. (provided by RefSeq, Jul 2008)

GeneCards Summary for RPS4X Gene:
RPS4X (ribosomal protein S4, X-linked) is a protein-coding gene. Diseases associated with RPS4X include band keratopathy, and cardiac tamponade. GO annotations related to this gene include structural constituent of ribosome and rRNA binding. An important paralog of this gene is RPS4Y2.

Gene Wiki entry for RPS4X Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_011651.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPS4X gene promoter:
         Oct-B1   Pax-5   p53   CUTL1   FAC1   NRF-2   POU2F1   POU2F1a   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPS4X promoter sequence
   Search Chromatin IP Primers for RPS4X

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPS4X


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq13.1   Ensembl cytogenetic band:  Xq13.1   HGNC cytogenetic band: Xq13.1

RPS4X Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS4X gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM071475:  view genomic region     (about GC identifiers)

Start:
71,475,529 bp from pter      End:
71,497,150 bp from pter
Size:
21,622 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RS4X_HUMAN, P62701 (See protein sequence)
Recommended Name: 40S ribosomal protein S4, X isoform  
Size: 263 amino acids; 29598 Da
Subunit: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs
1 PDB 3D structure from and Proteopedia for RPS4X:
3J3A (3D)    
Secondary accessions: P12631 P12750 P27576 P55831 Q14727 Q6IPY4

Explore the universe of human proteins at neXtProt for RPS4X: NX_P62701

Explore proteomics data for RPS4X at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys16, Lys22, Lys37, Lys53, Lys62, Lys63, Lys94, Lys134, Lys211, Lys233
  • Modification sites at PhosphoSitePlus

  • See RPS4X Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000998.1  
    ENSEMBL proteins: 
     ENSP00000362744   ENSP00000362729  
    Reactome Protein details: P62701

    RPS4X Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RPS: S ribosomal proteins

    Selected InterPro protein domains (see all 6):
     IPR013845 Ribosomal_S4e_central_region
     IPR002942 S4_RNA-bd
     IPR013843 Ribosomal_S4e_N
     IPR000876 Ribosomal_S4e
     IPR018199 Ribosomal_S4e_N_CS

    Graphical View of Domain Structure for InterPro Entry P62701

    ProtoNet protein and cluster: P62701

    2 Blocks protein domains:
    IPB000876 Ribosomal protein S4E
    IPB002942 RNA-binding S4


    UniProtKB/Swiss-Prot: RS4X_HUMAN, P62701
    Similarity: Belongs to the ribosomal protein S4e family
    Similarity: Contains 1 S4 RNA-binding domain


    RPS4X for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for RPS4X:
    40S ribosomal protein S4,29kDa,X-linked isoform,escaping inactivation

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding ----
    GO:0003735structural constituent of ribosome IMP8358435
    GO:0019843rRNA binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    RPS4X for ontologies           About GeneDecksing


    Phenotypes:
         10 GenomeRNAi human phenotypes for RPS4X:
     Decreased Hepatitis C virus re  Decreased homologous recombina  Decreased viability  Decreased viability of wild-ty 
     Increased S DNA content  Increased circadian period len  Increased gamma-H2AX phosphory  Nucleolar pre-40S maturation d 
     S arrest  Synthetic lethal with Ras 

    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target RPS4X:
    hsa-mir-320a (MIRT044434), hsa-mir-330-3p (MIRT043831), hsa-mir-22-3p (MIRT050453), hsa-mir-182-5p (MIRT047191), hsa-let-7b-5p (MIRT052233), hsa-mir-29b-3p (MIRT048379), hsa-let-7a-5p (MIRT052498), hsa-mir-92b-3p (MIRT040631), hsa-mir-23a-3p (MIRT050403), hsa-mir-30b-5p (MIRT046132), hsa-mir-29a-3p (MIRT049977), hsa-mir-186-5p (MIRT045173)

    Block miRNA regulation of human, mouse, rat RPS4X using miScript Target Protectors
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS4X

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RS4X_HUMAN, P62701: Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    mitochondrion2

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--
    GO:0005840ribosome IDA15883184
    GO:0005844polysome IDA8139551
    GO:0015935small ribosomal subunit IDA8139551

    RPS4X for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RPS4X About   (see all 6)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CFTR translational fidelity class I mutations
    CFTR translational fidelity class I mutations 0.60
    Ribosome0.54
    Cytoplasmic Ribosomal Proteins0.60
    2Influenza Viral RNA Transcription and Replication
    Viral mRNA Translation0.94
    Eukaryotic Translation Initiation0.89
    Peptide chain elongation0.94
    Cap-dependent Translation Initiation0.89
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    Formation of a pool of free 40S subunits0.94
    Nonsense-Mediated Decay0.89
    3Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
    Translation initiation complex formation0.91
    Ribosomal scanning and start codon recognition0.91
    Formation of the ternary complex, and subsequently, the 43S complex0.91
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.90
    4Gene Expression
    Gene Expression0.40
    5Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPS4X
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPS4X
        Cytoplasmic Ribosomal Proteins


    Selected Reactome Pathways for RPS4X (see all 12)
        Peptide chain elongation
    Formation of the ternary complex, and subsequently, the 43S complex
    Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
    Viral mRNA Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit


    1 Kegg Pathway  (Kegg details for RPS4X):
        Ribosome


    RPS4X for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RPS4X
    Interactions:

        GeneGlobe Interaction Network for RPS4X

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPS4X (P627012, 3 ENSP000003627444) via UniProtKB, MINT, STRING, and/or I2D (see all 658)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=2 
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    HIST1H4EP628053I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--
    GO:0006415translational termination TAS--

    RPS4X for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPS4X (RS4X)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RPS4X gene: 
    NM_001007.4  

    Unigene Cluster for RPS4X:

    Ribosomal protein S4, X-linked
    Hs.118076  [show with all ESTs]
    Unigene Representative Sequence: AK097914
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000470671 ENST00000492695 ENST00000316084(uc004ear.3) ENST00000486733(uc011mqb.2)
    ENST00000373626
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    GenScript: all cDNA clones in your preferred vector: RPS4X (NM_001007)
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      QuantiTect SYBR Green Assays in human, mouse, rat RPS4X
      QuantiFast Probe-based Assays in human, mouse, rat RPS4X

    Additional mRNA sequence: 

    AK097914.1 AK222479.1 AK293663.1 AK311745.1 BC000472.2 BC002569.1 BC007308.1 BC071662.1 
    BC100903.1 BC100904.1 CR456735.1 M22146.1 M58458.1 Z70767.1 

    Selected DOTS entries (see all 106):

    DT.80100887  DT.100703156  DT.100703187  DT.100703192  DT.100703154  DT.95306034  DT.121296613  DT.100703190 
    DT.100703180  DT.91842245  DT.91812692  DT.95200505  DT.100703164  DT.100703183  DT.91815578  DT.121296619 
    DT.121296525  DT.121296696  DT.121296701  DT.91842208  DT.100703157  DT.100703170  DT.100703167  DT.101988003 

    Selected AceView cDNA sequences (see all 4000):

    AA576542 BM769975 CB108483 AA157069 BQ643158 AA341380 BM797236 AA360991 
    BM696342 BM313761 BU180480 BU074195 CB120071 BM839708 AW406882 BQ549309 
    BU580100 BG105998 BU786839 BE302384 BM770721 T60125 BM845962 CA843361 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RPS4X (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b
    SP1:                          -     -                 -     -     -                                             
    SP2:                          -     -                 -     -     -                                             
    SP3:                          -     -                 -     -     -                                             
    SP4:                          -     -     -           -     -     -                                             
    SP5:                          -     -                 -                                                         


    ECgene alternative splicing isoforms for RPS4X

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RPS4X expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGATCTTT
    RPS4X Expression
    About this image

    RPS4X Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPS4X Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.118076
        Custom PCR Arrays for RPS4X
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS4X

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPS4X gene from Selected species (see all 28)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rps4x5 ribosomal protein S4, X-linked   --   X (45.20 cM) 102184941 
    chicken
    (Gallus gallus)
    Aves RPS4X1 ribosomal protein S4, X-linked 83.9(n)
    98.48(a)
      396001  NM_205108.1  NP_990439.1 
    lizard
    (Anolis carolinensis)
    Reptilia RPS4X6
    ribosomal protein S4, X-linked
    99(a)
    1 ↔ 1
    GL343686.1(237404-240652)
    African clawed frog
    (Xenopus laevis)
    Amphibia X64206.12   -- 85.71(n)    X64206.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hmzehn21852 hmzehn2185 82.01(n)   337759  57052169 
    fruit fly
    (Drosophila melanogaster)
    Insecta RpS41 , 3 protein biosynthesis structural
    constituent of more3
    Ribosomal protein S41
    75(a)3
    69.24(n)1
    76.06(a)1
      69F63
    394841  NM_168537.21  NP_729871.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y43B11AR.43
    rps-41
    rps-41 64(a)3
    62.02(n)1
    64.73(a)1
      IV(7083923-7084849)3
    1774811  NM_068702.41  NP_501103.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPS4A(YJR145C)4
    RPS4B1
    Protein component of the small (40S) ribosomal subunit; more4
    RPS4B1
    65.64(n)1
    72.59(a)1
      10(703068-702027)4
    8566101  NP_012073.11  8536104 
     NP_012679.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G173601 AT2G17360 63.47(n)
    70.11(a)
      816243  NM_127291.3  NP_565414.1 
    rice
    (Oryza sativa)
    Liliopsida Os.84662 Oryza sativa (japonica cultivar-group) cDNA clone0 more 76.69(n)    AK061826.1 


    ENSEMBL Gene Tree for RPS4X (if available)
    TreeFam Gene Tree for RPS4X (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RPS4X gene
    RPS4Y22  RPS4Y12  
    2 SIMAP similar genes for RPS4X using alignment to 4 protein entries:     RS4X_HUMAN (see all proteins):
    RPS4Y1    RPS4Y2

    RPS4X for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for RPS4X (see all 22)
    PGOHUM00000238394 PGOHUM00000242288 PGOHUM00000242510 PGOHUM00000239291 PGOHUM00000239471


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RPS4X (see all 151)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs345639811,2
    C--65250508(+) AACTT-/AC    
       T
    /CTA
    CTTAC
    2 -- cds13CSA 6
    rs1127658121,2
    C--65250508(+) AAACTA/TCTTAC 1 -- int10--------
    rs38424721,2
    C,F--71495390(+) CTTCTACT/-TACCC 1 -- cds11Minor allele frequency- -:0.08NS 144
    rs1470403101,2
    C--71497578(+) GTCCAA/GGGAAC 1 -- ds50011Minor allele frequency- G:0.01NS 148
    rs1393292631,2
    --71497615(+) CATTTA/GTGACC 1 -- ds50010--------
    rs456246421,2
    C,F--71497832(+) GAGATA/CAATAC 1 -- ds50011Minor allele frequency- C:0.03NS 144
    rs1472329791,2
    --71497840(+) TACTCC/TGGGAT 1 -- ds50010--------
    rs1864923911,2
    --71497841(+) ACTCCA/GGGATT 1 -- ds50010--------
    rs1139699081,2
    C--71497920(+) CACTAA/GCTAAG 1 -- ds50012Minor allele frequency- G:0.02CSA NS 145
    rs1917734471,2
    --71497995(+) AAATAG/TCAGGA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for RPS4X (71475529 - 71497150 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RPS4X:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2740222CNV Deletion23290073
    esv2740221CNV Deletion23290073

    Locus Specific Mutation Databases (LSDB): RPS4X

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RPS4X
    DNA2.0 Custom Variant and Variant Library Synthesis for RPS4X

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 312760    OMIM disorders: --

    12 diseases for RPS4X:    About MalaCards
    band keratopathy    cardiac tamponade    turner syndrome    keratopathy
    stevens-johnson syndrome    treacher collins syndrome    wiskott-aldrich syndrome    fanconi's anemia
    influenza    hiv-1    breast cancer    malaria

    1 disease from the University of Copenhagen DISEASES database for RPS4X:
    Turner syndrome

    RPS4X for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for RPS4X gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    turners syndrome 82.2 3 1587534 (2), 8557258 (1)
    monosomy 78.2 3 8808278 (2)


    Export disorders for RPS4X gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RPS4X gene, integrated from 10 sources (see all 82):
    (articles sorted by number of sources associating them with RPS4X)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the human gene, CCG2, that complements the BHK- derived temperature-sensitive cell cycle mutant tsBN63: identity of CCG2 with the human X chromosomal SCAR/RPS4X gene. (PubMed id 1795030)1, 2, 3, 9 Watanabe M.... Nishimoto T. (J. Cell Sci. 1991)
    2. Homologous ribosomal protein genes on the human X and Y chromosomes: escape from X inactivation and possible implications for Turner syndrome. (PubMed id 2124517)1, 2, 9 Fisher E.M.C.... Page D.C. (Cell 1990)
    3. Structure and function of ribosomal protein S4 genes on the human and mouse sex chromosomes. (PubMed id 8139551)1, 3, 9 Zinn A.R....Page D.C. (Mol. Cell. Biol. 1994)
    4. Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)1, 2 Joeson L.... Nielsen F.C. (Mol. Cell. Proteomics 2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699)1, 2 Vladimirov S.N.... Otto A. (Eur. J. Biochem. 1996)
    7. Isolation of an abundantly expressed sequence from the human X chromosome by differential screening. (PubMed id 2829364)1, 2 Wiles M.V.... Goodfellow P.N. (Somat. Cell Mol. Genet. 1988)
    8. Ullrich-Turner syndrome is not caused by haploinsufficiency of RPS4X. (PubMed id 8557258)1, 9 Geerkens C....Vogel W. (Hum. Genet. 1996)
    9. Relationship between the monosomy X phenotype and Y-linked ribosomal protein S4 (Rps4) in several species of mammals: a molecular evolutionary analysis of Rps4 homologs. (PubMed id 8808278)1, 9 Omoe K. and Endo A. (Genomics 1996)
    10. Functional equivalence of human X- and Y-encoded isoforms of ribosomal protein S4 consistent with a role in Turner syndrome. (PubMed id 8358435)1, 9 Watanabe M....Nishimoto T. (Nat. Genet. 1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6191 HGNC: 10424 AceView: RPS4X Ensembl:ENSG00000198034 euGenes: HUgn6191
    ECgene: RPS4X Kegg: 6191 H-InvDB: RPS4X

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RPS4X Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RPS4X gene:
    Search GeneIP for patents involving RPS4X

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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