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Aliases for RPS3A Gene

Aliases for RPS3A Gene

  • Ribosomal Protein S3A 2 3
  • Fte-1 3 4
  • MFTL 3 4
  • FTE1 3 4
  • V-Fos Transformation Effector Protein 1 3
  • V-Fos Transformation Effector Protein 4
  • 40S Ribosomal Protein S3a 3
  • S3A 3

External Ids for RPS3A Gene

Previous Symbols for RPS3A Gene

  • MFTL

Summaries for RPS3A Gene

Entrez Gene Summary for RPS3A Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S3AE family of ribosomal proteins. It is located in the cytoplasm. Disruption of the gene encoding rat ribosomal protein S3a, also named v-fos transformation effector protein, in v-fos-transformed rat cells results in reversion of the transformed phenotype. This gene is co-transcribed with the U73A and U73B small nucleolar RNA genes, which are located in its fourth and third introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for RPS3A Gene

RPS3A (Ribosomal Protein S3A) is a Protein Coding gene. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include RNA binding and structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPS3A Gene

  • May play a role during erythropoiesis through regulation of transcription factor DDIT3.

Gene Wiki entry for RPS3A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS3A Gene

Genomics for RPS3A Gene

Genomic Location for RPS3A Gene

Start:
151,099,573 bp from pter
End:
151,104,652 bp from pter
Size:
5,080 bases
Orientation:
Plus strand

Genomic View for RPS3A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPS3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS3A Gene

Regulatory Elements for RPS3A Gene

Proteins for RPS3A Gene

  • Protein details for RPS3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61247-RS3A_HUMAN
    Recommended name:
    40S ribosomal protein S3a
    Protein Accession:
    P61247
    Secondary Accessions:
    • B2R4D4
    • D3DP05
    • P33443
    • P49241

    Protein attributes for RPS3A Gene

    Size:
    264 amino acids
    Molecular mass:
    29945 Da
    Quaternary structure:
    • Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.

    Three dimensional structures from OCA and Proteopedia for RPS3A Gene

neXtProt entry for RPS3A Gene

Proteomics data for RPS3A Gene at MOPED

Post-translational modifications for RPS3A Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys34, Lys46, Lys63, Lys94, Lys167, Lys182, Lys187, Lys199, Lys227, Lys240, and Lys249

No data available for DME Specific Peptides for RPS3A Gene

Domains for RPS3A Gene

Gene Families for RPS3A Gene

HGNC:
  • RPS :S ribosomal proteins

Protein Domains for RPS3A Gene

UniProtKB/Swiss-Prot:

RS3A_HUMAN
Family:
  • Belongs to the ribosomal protein S3Ae family.:
    • P61247
genes like me logo Genes that share domains with RPS3A: view

Function for RPS3A Gene

Molecular function for RPS3A Gene

GENATLAS Biochemistry: 40S ribosomal protein S3,pseudogene
UniProtKB/Swiss-Prot Function: May play a role during erythropoiesis through regulation of transcription factor DDIT3.

Gene Ontology (GO) - Molecular Function for RPS3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding NAS 1398113
GO:0003735 structural constituent of ribosome IBA --
GO:0005515 protein binding IPI 11823430
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPS3A: view
genes like me logo Genes that share phenotypes with RPS3A: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPS3A Gene

Localization for RPS3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS3A Gene

Cytoplasm. Nucleus. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS3A Gene COMPARTMENTS Subcellular localization image for RPS3A gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPS3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus ISS --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RPS3A: view

Pathways for RPS3A Gene

SuperPathways for RPS3A Gene

Superpath Contained pathways
1 Influenza Viral RNA Transcription and Replication
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 CFTR translational fidelity (class I mutations)
.54
4 Disease
5 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
genes like me logo Genes that share pathways with RPS3A: view

Pathways by source for RPS3A Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for RPS3A Gene
1 BioSystems pathway for RPS3A Gene

Gene Ontology (GO) - Biological Process for RPS3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002181 cytoplasmic translation IBA --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS 9566973
GO:0006414 translational elongation TAS --
genes like me logo Genes that share ontologies with RPS3A: view

Transcripts for RPS3A Gene

Unigene Clusters for RPS3A Gene

Ribosomal protein S3A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPS3A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7
SP1: - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - -
SP5: - -
SP6: -
SP7: - - - - - -

Relevant External Links for RPS3A Gene

GeneLoc Exon Structure for
RPS3A
ECgene alternative splicing isoforms for
RPS3A

Expression for RPS3A Gene

mRNA expression in normal human tissues for RPS3A Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS3A Gene

SOURCE GeneReport for Unigene cluster for RPS3A Gene Hs.356572

genes like me logo Genes that share expressions with RPS3A: view

Orthologs for RPS3A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS3A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPS3A 36
  • 100 (n)
  • 100 (a)
RPS3A 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 72 (a)
OneToMany
-- 37
  • 98 (a)
OneToMany
RPS3A 36
  • 92.8 (n)
  • 100 (a)
RPS3A 37
  • 100 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RPS3A 36
  • 93.56 (n)
  • 100 (a)
RPS3A 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rps3a1 16
Rps3a1 37
  • 99 (a)
OneToMany
Rps3a2 37
  • 99 (a)
OneToMany
Rps3a3 37
  • 98 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia RPS3A 37
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPS3A 37
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100365839 36
  • 89.14 (n)
  • 98.48 (a)
chicken
(Gallus gallus)
Aves RPS3A 37
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPS3A 37
  • 96 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia rps3a-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6700 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8315 36
zebrafish
(Danio rerio)
Actinopterygii rps3a 37
  • 93 (a)
OneToOne
wufb02h01 36
fruit fly
(Drosophila melanogaster)
Insecta RpS3A 37
  • 68 (a)
OneToOne
RpS3A 38
  • 67 (a)
worm
(Caenorhabditis elegans)
Secernentea rps-1 36
  • 63.42 (n)
  • 64.98 (a)
rps-1 37
  • 65 (a)
OneToOne
rps-1 38
  • 62 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS1A 37
  • 51 (a)
OneToMany
RPS1B 37
  • 52 (a)
OneToMany
RPS1B 39
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7235 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4971 37
  • 73 (a)
OneToOne
Species with no ortholog for RPS3A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS3A Gene

ENSEMBL:
Gene Tree for RPS3A (if available)
TreeFam:
Gene Tree for RPS3A (if available)

Paralogs for RPS3A Gene

genes like me logo Genes that share paralogs with RPS3A: view

No data available for Paralogs for RPS3A Gene

Variants for RPS3A Gene

Sequence variations from dbSNP and Humsavar for RPS3A Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs2280282 -- 151,100,804(-) GCTCA(C/G)AACTA intron-variant
rs2280283 -- 151,099,625(-) GGGCG(A/G)AAGTG utr-variant-5-prime
rs2952810 -- 151,098,778(-) tccca(G/T)cactt upstream-variant-2KB
rs3828490 -- 151,098,941(-) TGGCT(C/G)ACACC upstream-variant-2KB
rs4696226 -- 151,099,077(+) CAGCA(C/T)CCACA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPS3A Gene

Variant ID Type Subtype PubMed ID
nsv526976 CNV Gain 19592680
nsv880262 CNV Gain 21882294
nsv881526 CNV Gain 21882294

Relevant External Links for RPS3A Gene

HapMap Linkage Disequilibrium report
RPS3A

Disorders for RPS3A Gene

No disorders were found for RPS3A Gene.

No data available for UniProtKB/Swiss-Prot for RPS3A Gene

Publications for RPS3A Gene

  1. The human S3a ribosomal protein: sequence, location and cell-free transcription of the functional gene. (PMID: 8647443) Nolte D. … Seifart K.H. (Gene 1996) 2 3 4 23
  2. Human ribosomal protein S3a: cloning of the cDNA and primary structure of the protein. (PMID: 1398113) Metspalu A. … Kruppa J. (Gene 1992) 2 3 4 23
  3. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 3 4
  4. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PMID: 8706699) Vladimirov S.N. … Otto A. (Eur. J. Biochem. 1996) 3 4
  5. Importins fulfill a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains. (PMID: 11823430) Jaekel S. … Goerlich D. (EMBO J. 2002) 3 4

Products for RPS3A Gene

Sources for RPS3A Gene

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