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RPS3A Gene

protein-coding   GIFtS: 62
GCID: GC04P152020

Ribosomal Protein S3A


(Previous symbol: MFTL)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribosomal Protein S3A1 2     fte-12
MFTL1 2 3     V-Fos Transformation Effector Protein 12
FTE12 3     Fte-13
40S Ribosomal Protein S3a2     V-Fos Transformation Effector Protein3
S3A2     

External Ids:    HGNC: 104211   Entrez Gene: 61892   Ensembl: ENSG000001454257   OMIM: 1804785   UniProtKB: P612473   

Export aliases for RPS3A gene to outside databases

Previous GC identifers: GC04P152874 GC04P152409 GC04P152486 GC04P152598 GC04P152593 GC04P152378 GC04P152240


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RPS3A Gene:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This
gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S3AE family
of ribosomal proteins. It is located in the cytoplasm. Disruption of the gene encoding rat ribosomal protein S3a,
also named v-fos transformation effector protein, in v-fos-transformed rat cells results in reversion of the
transformed phenotype. This gene is co-transcribed with the U73A and U73B small nucleolar RNA genes, which are
located in its fourth and third introns, respectively. As is typical for genes encoding ribosomal proteins, there
are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript
variants have been found for this gene. (provided by RefSeq, May 2012)

GeneCards Summary for RPS3A Gene:
RPS3A (ribosomal protein S3A) is a protein-coding gene. Diseases associated with RPS3A include pure red-cell aplasia, and diamond-blackfan anemia. GO annotations related to this gene include structural constituent of ribosome and RNA binding.

UniProtKB/Swiss-Prot: RS3A_HUMAN, P61247
Function: May play a role during erythropoiesis through regulation of transcription factor DDIT3 (By similarity)

Gene Wiki entry for RPS3A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPS3A gene promoter:
         STAT5B   E2F-5   Ik-3   GATA-1   C/EBPalpha   HEN1   PPAR-gamma1   NRF-2   COMP1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPS3A promoter sequence
   Search Chromatin IP Primers for RPS3A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPS3A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31.2-q31.3   Ensembl cytogenetic band:  4q31.3   HGNC cytogenetic band: 4q31.2-q31.3

RPS3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS3A gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P152020:  view genomic region     (about GC identifiers)

Start:
152,020,725 bp from pter      End:
152,025,804 bp from pter
Size:
5,080 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RS3A_HUMAN, P61247 (See protein sequence)
Recommended Name: 40S ribosomal protein S3a  
Size: 264 amino acids; 29945 Da
Subunit: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S)
subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit
contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent
mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3
1 PDB 3D structure from and Proteopedia for RPS3A:
3J3A (3D)    
Secondary accessions: B2R4D4 D3DP05 P33443 P49241

Explore the universe of human proteins at neXtProt for RPS3A: NX_P61247

Explore proteomics data for RPS3A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys34, Lys46, Lys63, Lys94, Lys167, Lys182, Lys187, Lys199, Lys227, Lys240,
                                 Lys249
  • Modification sites at PhosphoSitePlus

  • See RPS3A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000997.1  NP_001254628.1  

    ENSEMBL proteins: 
     ENSP00000346050   ENSP00000422994   ENSP00000425024   ENSP00000425978   ENSP00000421770  
     ENSP00000421277   ENSP00000423953   ENSP00000421776   ENSP00000421457   ENSP00000424547  
     ENSP00000425508   ENSP00000426282   ENSP00000426466   ENSP00000444951  
    Reactome Protein details: P61247

    RPS3A Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RPS: S ribosomal proteins

    3 InterPro protein domains:
     IPR001593 Ribosomal_S3Ae
     IPR027500 Ribosomal_S1/3_euk
     IPR018281 Ribosomal_S3Ae_CS

    Graphical View of Domain Structure for InterPro Entry P61247

    ProtoNet protein and cluster: P61247

    UniProtKB/Swiss-Prot: RS3A_HUMAN, P61247
    Similarity: Belongs to the ribosomal protein S3Ae family


    RPS3A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RS3A_HUMAN, P61247
    Function: May play a role during erythropoiesis through regulation of transcription factor DDIT3 (By similarity)

         Genatlas biochemistry entry for RPS3A:
    40S ribosomal protein S3,pseudogene

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding NAS1398113
    GO:0003735structural constituent of ribosome IBA--
    GO:0005515protein binding IPI11823430
    GO:0044822poly(A) RNA binding IDA--
         
    RPS3A for ontologies           About GeneDecksing


    Phenotypes:
         8 GenomeRNAi human phenotypes for RPS3A:
     Decreased Hepatitis C virus re  Decreased cell number  Decreased homologous recombina  Decreased viability 
     Decreased viability of wild-ty  Increased number of mitotic ce  Nucleolar pre-40S maturation d  S arrest 

    Animal Models:
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    miRNA
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    hsa-mir-92b-3p (MIRT040576), hsa-mir-15b-5p (MIRT046394), hsa-mir-92a-3p (MIRT049447), hsa-mir-7-5p (MIRT047756), hsa-mir-342-3p (MIRT043671), hsa-let-7a-5p (MIRT052412), hsa-mir-25-3p (MIRT050354), hsa-mir-16-5p (MIRT032020), hsa-mir-125b-5p (MIRT045970)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RS3A_HUMAN, P61247: Cytoplasm. Nucleus (By similarity). Note=Localized in cytoplasmic mRNP granules containing
    untranslated mRNAs
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ISS--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--

    RPS3A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RPS3A About   (see all 6)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CFTR translational fidelity class I mutations
    CFTR translational fidelity class I mutations 0.60
    Ribosome0.54
    Cytoplasmic Ribosomal Proteins0.60
    2Influenza Viral RNA Transcription and Replication
    Viral mRNA Translation0.94
    Eukaryotic Translation Initiation0.89
    Peptide chain elongation0.94
    Cap-dependent Translation Initiation0.89
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    Formation of a pool of free 40S subunits0.94
    Nonsense-Mediated Decay0.89
    3Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
    Translation initiation complex formation0.91
    Ribosomal scanning and start codon recognition0.91
    Formation of the ternary complex, and subsequently, the 43S complex0.91
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.90
    4Gene Expression
    Gene Expression0.40
    5Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPS3A
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPS3A
        Cytoplasmic Ribosomal Proteins


    Selected Reactome Pathways for RPS3A (see all 12)
        Peptide chain elongation
    Formation of the ternary complex, and subsequently, the 43S complex
    Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
    Viral mRNA Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit


    1 Kegg Pathway  (Kegg details for RPS3A):
        Ribosome


    RPS3A for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including RPS3A: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RPS3A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPS3A (P612471, 2, 3 ENSP000003460504) via UniProtKB, MINT, STRING, and/or I2D (see all 466)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPL35P427662, 3, ENSP000002594694MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=3 STRING: ENSP00000259469
    RPS6P627532, 3, ENSP000003697574MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=3 STRING: ENSP00000369757
    RPL4P365782, 3, ENSP000003114304MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=2 STRING: ENSP00000311430
    RPL11P629132, 3, ENSP000003636764MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=1 STRING: ENSP00000363676
    RPL26P612542, 3, ENSP000002938424MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=1 STRING: ENSP00000293842
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0002181cytoplasmic translation IBA--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS9566973
    GO:0006414translational elongation TAS--

    RPS3A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPS3A (RS3A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RPS3A gene (2 alternative transcripts): 
    NM_001006.4  NM_001267699.1  

    Unigene Cluster for RPS3A:

    Ribosomal protein S3A
    Hs.356572  [show with all ESTs]
    Unigene Representative Sequence: BI087817
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000274065(uc003ilz.3) ENST00000509736 ENST00000505243 ENST00000507485(uc011cie.1)
    ENST00000515818 ENST00000514682 ENST00000503002 ENST00000512690 ENST00000508783
    ENST00000512797 ENST00000507327 ENST00000515792 ENST00000506126 ENST00000510993
    ENST00000322686
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    Additional mRNA sequence: 

    AK129825.1 AK291075.1 AK296121.1 AK308947.1 AK311788.1 BC000204.1 BC001708.1 BC004981.1 
    BC006298.2 BC009219.2 BC009404.2 BC017123.2 BC018954.2 BC019072.2 BC030161.2 BC066926.1 
    BC070211.1 BC071916.1 L13802.1 M77234.1 M84711.1 

    Selected DOTS entries (see all 137):

    DT.100835618  DT.121223319  DT.100745424  DT.100745460  DT.420987  DT.99926659  DT.92475215  DT.92475113 
    DT.95273194  DT.91679487  DT.100745415  DT.100042734  DT.100061201  DT.100647812  DT.100876054  DT.100745439 
    DT.100745453  DT.92475125  DT.92475069  DT.91840823  DT.100745340  DT.121223167  DT.100728440  DT.95273429 

    Selected AceView cDNA sequences (see all 6227):

    BF095465 BQ059138 BU838736 BQ877019 BQ224928 BG341623 BQ651821 BQ439957 
    BQ000411 BQ056674 BG490377 CB162201 BE256256 BQ687388 AW022331 BM849514 
    BE221653 CA773526 BM745828 BM833226 BG292009 BQ670712 BU189712 BE293589 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RPS3A (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7
    SP1:              -     -                       -           -     -     -                     
    SP2:                    -                       -           -     -     -                     
    SP3:                                            -           -     -     -                     
    SP4:              -     -                       -                                             
    SP5:              -     -                                                                     


    ECgene alternative splicing isoforms for RPS3A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RPS3A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGAAGGCAG
    RPS3A Expression
    About this image

    RPS3A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPS3A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.356572
        Pathway & Disease-focused RT2 Profiler PCR Array including RPS3A: 
              Apoptosis 384HT in human mouse rat

    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS3A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPS3A gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rps3a15 ribosomal protein S3A   --   3 (37.83 cM) 86137940 
    chicken
    (Gallus gallus)
    Aves RPS3A6
    Gallus gallus ribosomal protein S3A (RPS3A), mRNA....
    97(a)
    1 ↔ 1
    4(32682086-32685468)
    lizard
    (Anolis carolinensis)
    Reptilia RPS3A6
    ribosomal protein S3A
    96(a)
    1 ↔ 1
    5(132534696-132541712)
    African clawed frog
    (Xenopus laevis)
    Amphibia rps3a-prov2 ribosomal protein S3a 82.78(n)    BC047260.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb02h012 wufb02h01 76.08(n)   337240  BC059543.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RpS3A3 protein biosynthesis structural
    constituent of more
    67(a)   4 102A3   --
    worm
    (Caenorhabditis elegans)
    Secernentea rps-11 , 3 Ribosomal protein S3a (human) homolog.3
    rps-11
    62(a)3
    63.42(n)1
    64.98(a)1
      III(4547741-4548608)3
    1755841  NM_065509.51  NP_497910.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPS1B(YML063W)4 Ribosomal protein 10 (rp10) of the small (40S) subunit; more   --   13(146482-147249) 854939  NP_013648.1 
    Alicante grape
    (Vitis vinifera)
    eudicotyledons Vvi.72352 Vitis vinifera transcribed sequence with moderate similarity more 72.94(n)    CF208927.1 
    rice
    (Oryza sativa)
    Liliopsida AK104243.12   -- 76.06(n)    AK104243.1 


    ENSEMBL Gene Tree for RPS3A (if available)
    TreeFam Gene Tree for RPS3A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RPS3A gene
    1 SIMAP similar gene for RPS3A using alignment to 16 protein entries:     RS3A_HUMAN (see all proteins):
    LOC402287

    RPS3A for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for RPS3A (see all 65)
    PGOHUM00000251247 PGOHUM00000251272 PGOHUM00000238864 PGOHUM00000238898 PGOHUM00000242123


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RPS3A (see all 123)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1900177821,2
    --152018734(+) TACAGA/GTGTGC 2 -- us2k10--------
    rs1821405871,2
    --152018763(+) TTTTTA/GTATTT 2 -- us2k10--------
    rs1174989491,2
    C,F--152018920(+) AGCCGG/AGCTAA 2 -- us2k11Minor allele frequency- A:0.02EA 120
    rs1473924051,2
    C--152019047(+) TGAGCC/TACCAC 2 -- us2k10--------
    rs1484610591,2
    C--152019113(+) TGTTGC/TCCAGG 2 -- us2k10--------
    rs1140232551,2
    F--152019169(+) TCCGAA/GTACCT 2 -- us2k11Minor allele frequency- G:0.02WA 118
    rs117342871,2
    H--152019551(+) GGCCAC/GATGCT 2 -- us2k10--------
    rs68302601,2
    C,H--152019634(+) AAAAAA/TTGGGG 2 -- us2k14Minor allele frequency- T:0.00NS EA 418
    rs1135532791,2
    C--152019688(+) TCACTT/-TTTTT 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs106773271,2
    C--152019700(+) TTTTT-/T/TT  
            
    GACGC
    2 -- us2k11NA 2

    HapMap Linkage Disequilibrium report for RPS3A (152020725 - 152025804 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RPS3A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv880262CNV Gain21882294
    nsv526976CNV Gain19592680
    nsv881526CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RPS3A
    DNA2.0 Custom Variant and Variant Library Synthesis for RPS3A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 180478    OMIM disorders: --

    14 diseases for RPS3A:    
    About MalaCards
    pure red-cell aplasia    diamond-blackfan anemia    fanconi's anemia    non-hodgkin lymphoma
    hodgkin's lymphoma    influenza    hepatitis c    hepatocellular carcinoma
    hepatitis    alzheimer's disease    lung cancer    hiv-1
    breast cancer    malaria


    RPS3A for disorders           About GeneDecksing


    Export disorders for RPS3A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RPS3A gene, integrated from 10 sources (see all 109):
    (articles sorted by number of sources associating them with RPS3A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human S3a ribosomal protein: sequence, location and cell-free transcription of the functional gene. (PubMed id 8647443)1, 2, 3, 9 Nolte D.... Seifart K.H. (Gene 1996)
    2. Human ribosomal protein S3a: cloning of the cDNA and primary structure of the protein. (PubMed id 1398113)1, 2, 3, 9 Metspalu A.... Kruppa J. (Gene 1992)
    3. Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)1, 2 Joeson L.... Nielsen F.C. (Mol. Cell. Proteomics 2007)
    4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    6. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Importins fulfill a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains. (PubMed id 11823430)1, 2 Jaekel S.... Goerlich D. (EMBO J. 2002)
    9. A map of 75 human ribosomal protein genes. (PubMed id 9582194)1, 2 Kenmochi N.... Page D.C. (Genome Res. 1998)
    10. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699)1, 2 Vladimirov S.N.... Otto A. (Eur. J. Biochem. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6189 HGNC: 10421 AceView: RPS3A Ensembl:ENSG00000145425 euGenes: HUgn6189
    ECgene: RPS3A Kegg: 6189 H-InvDB: RPS3A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RPS3A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RPS3A gene:
    Search GeneIP for patents involving RPS3A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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