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Aliases for RPS3A Gene

Aliases for RPS3A Gene

  • Ribosomal Protein S3A 2 3 5
  • Fte-1 3 4
  • MFTL 3 4
  • FTE1 3 4
  • V-Fos Transformation Effector Protein 1 3
  • V-Fos Transformation Effector Protein 4
  • 40S Ribosomal Protein S3a 3
  • S3A 3

External Ids for RPS3A Gene

Previous HGNC Symbols for RPS3A Gene

  • MFTL

Previous GeneCards Identifiers for RPS3A Gene

  • GC04P152874
  • GC04P152409
  • GC04P152486
  • GC04P152598
  • GC04P152593
  • GC04P152378
  • GC04P152240
  • GC04P152020

Summaries for RPS3A Gene

Entrez Gene Summary for RPS3A Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S3AE family of ribosomal proteins. It is located in the cytoplasm. Disruption of the gene encoding rat ribosomal protein S3a, also named v-fos transformation effector protein, in v-fos-transformed rat cells results in reversion of the transformed phenotype. This gene is co-transcribed with the U73A and U73B small nucleolar RNA genes, which are located in its fourth and third introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for RPS3A Gene

RPS3A (Ribosomal Protein S3A) is a Protein Coding gene. Diseases associated with RPS3A include Diamond-Blackfan Anemia. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Metabolism. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPS3A Gene

  • May play a role during erythropoiesis through regulation of transcription factor DDIT3.

Gene Wiki entry for RPS3A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS3A Gene

Genomics for RPS3A Gene

Regulatory Elements for RPS3A Gene

Enhancers for RPS3A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F151097 0.8 ENCODE 29.8 +0.5 478 4.5 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 RPS3A ENSG00000249708 ENSG00000249818 FAM160A1 SH3D19 ENSG00000270681 GC04P151100 GC04P151105 GC04P151106 GC04P151107
GH04F150178 0.2 ENCODE 23.5 -921.2 -921190 0.2 HDGF PKNOX1 MLX ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 RPS3A DCLK2 RNU7-194P GC04P150129
GH04F151760 0.2 ENCODE 12.2 +661.3 661325 1.7 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 GATB RPS3A GC04P151731
GH04F151029 0.9 ENCODE 11.9 -69.5 -69545 0.8 BCOR BMI1 ZNF316 POLR2A FOXK2 CBX5 EED NFE2 TRIM24 CREM RPS3A SNORD73B AK4P6 GC04M151092
GH04F151034 0.2 ENCODE 10.8 -64.2 -64175 2.2 SOX13 PKNOX1 ZNF384 CEBPG RAD21 TEAD3 CTBP1 ZNF26 RCOR1 SOX5 RPS3A AK4P6 GC04M151092
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RPS3A on UCSC Golden Path with GeneCards custom track

Promoters for RPS3A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001251950 527 2601 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for RPS3A Gene

Chromosome:
4
Start:
151,099,573 bp from pter
End:
151,104,652 bp from pter
Size:
5,080 bases
Orientation:
Plus strand

Genomic View for RPS3A Gene

Genes around RPS3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS3A Gene

Proteins for RPS3A Gene

  • Protein details for RPS3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61247-RS3A_HUMAN
    Recommended name:
    40S ribosomal protein S3a
    Protein Accession:
    P61247
    Secondary Accessions:
    • B2R4D4
    • D3DP05
    • P33443
    • P49241

    Protein attributes for RPS3A Gene

    Size:
    264 amino acids
    Molecular mass:
    29945 Da
    Quaternary structure:
    • Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.

    Three dimensional structures from OCA and Proteopedia for RPS3A Gene

neXtProt entry for RPS3A Gene

Post-translational modifications for RPS3A Gene

  • Ubiquitination at Lys 34, Lys 46, Lys 63, Lys 94, Lys 167, Lys 182, Lys 187, Lys 199, Lys 227, Lys 240, and Lys 249
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPS3A Gene

Domains & Families for RPS3A Gene

Gene Families for RPS3A Gene

Protein Domains for RPS3A Gene

Suggested Antigen Peptide Sequences for RPS3A Gene

Graphical View of Domain Structure for InterPro Entry

P61247

UniProtKB/Swiss-Prot:

RS3A_HUMAN :
  • Belongs to the ribosomal protein S3Ae family.
Family:
  • Belongs to the ribosomal protein S3Ae family.
genes like me logo Genes that share domains with RPS3A: view

Function for RPS3A Gene

Molecular function for RPS3A Gene

GENATLAS Biochemistry:
40S ribosomal protein S3,pseudogene
UniProtKB/Swiss-Prot Function:
May play a role during erythropoiesis through regulation of transcription factor DDIT3.

Gene Ontology (GO) - Molecular Function for RPS3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding NAS 1398113
GO:0003735 structural constituent of ribosome IEA --
GO:0005515 protein binding IPI 11823430
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPS3A: view
genes like me logo Genes that share phenotypes with RPS3A: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS3A Gene

Localization for RPS3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS3A Gene

Cytoplasm. Nucleus. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS3A Gene COMPARTMENTS Subcellular localization image for RPS3A gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPS3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,ISS --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA 15572026
GO:0005737 cytoplasm IEA,IDA 11823430
genes like me logo Genes that share ontologies with RPS3A: view

Pathways & Interactions for RPS3A Gene

SuperPathways for RPS3A Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
.55
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing in the nucleus and cytosol
5 HIV Life Cycle
.45
genes like me logo Genes that share pathways with RPS3A: view

Gene Ontology (GO) - Biological Process for RPS3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,NAS 1398113
GO:0006413 translational initiation TAS 9566973
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPS3A: view

No data available for SIGNOR curated interactions for RPS3A Gene

Transcripts for RPS3A Gene

Unigene Clusters for RPS3A Gene

Ribosomal protein S3A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS3A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7
SP1: - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - -
SP5: - -
SP6: -
SP7: - - - - - -

Relevant External Links for RPS3A Gene

GeneLoc Exon Structure for
RPS3A
ECgene alternative splicing isoforms for
RPS3A

Expression for RPS3A Gene

mRNA expression in normal human tissues for RPS3A Gene

Protein differential expression in normal tissues from HIPED for RPS3A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPS3A Gene



Protein tissue co-expression partners for RPS3A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS3A Gene:

RPS3A

SOURCE GeneReport for Unigene cluster for RPS3A Gene:

Hs.356572
genes like me logo Genes that share expression patterns with RPS3A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS3A Gene

Orthologs for RPS3A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS3A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPS3A 34 35
  • 100 (n)
mouse
(Mus musculus)
Mammalia Rps3a1 35
  • 99 (a)
OneToMany
Rps3a2 35
  • 99 (a)
OneToMany
Rps3a3 35
  • 98 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 98 (a)
OneToMany
RPS3A 34 35
  • 92.8 (n)
-- 35
  • 72 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia RPS3A 35
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPS3A 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPS3A 34 35
  • 93.56 (n)
rat
(Rattus norvegicus)
Mammalia LOC100365839 34
  • 89.14 (n)
chicken
(Gallus gallus)
Aves RPS3A 35
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPS3A 35
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6700 34
African clawed frog
(Xenopus laevis)
Amphibia rps3a-prov 34
zebrafish
(Danio rerio)
Actinopterygii rps3a 35
  • 93 (a)
OneToOne
wufb02h01 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8315 34
fruit fly
(Drosophila melanogaster)
Insecta RpS3A 36 35
  • 67 (a)
worm
(Caenorhabditis elegans)
Secernentea rps-1 36 34 35
  • 63.42 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS1B 35 37
  • 52 (a)
OneToMany
RPS1A 35
  • 51 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7235 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4971 35
  • 73 (a)
OneToOne
Species where no ortholog for RPS3A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS3A Gene

ENSEMBL:
Gene Tree for RPS3A (if available)
TreeFam:
Gene Tree for RPS3A (if available)

Paralogs for RPS3A Gene

genes like me logo Genes that share paralogs with RPS3A: view

No data available for Paralogs for RPS3A Gene

Variants for RPS3A Gene

Sequence variations from dbSNP and Humsavar for RPS3A Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10594186 -- 151,102,480(+) GATGT(-/G)TTCAT intron-variant, upstream-variant-2KB
rs10677327 -- 151,098,548(+) TTTTT(-/T)GACGC upstream-variant-2KB
rs111471748 -- 151,098,979(+) AAAAC(C/T)TTTTA upstream-variant-2KB
rs112701183 -- 151,098,278(+) AAAGC(C/T)TGCAG upstream-variant-2KB
rs112711579 -- 151,103,624(+) AAGTT(C/G)AGTGG intron-variant, upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RPS3A Gene

Variant ID Type Subtype PubMed ID
dgv5436n100 CNV gain 25217958
esv2763837 CNV gain+loss 21179565
esv3602674 CNV gain 21293372
nsv1028814 CNV gain 25217958
nsv526976 CNV gain 19592680
nsv595690 CNV gain 21841781
nsv964104 CNV duplication 23825009

Variation tolerance for RPS3A Gene

Residual Variation Intolerance Score: 44.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS3A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPS3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS3A Gene

Disorders for RPS3A Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPS3A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
diamond-blackfan anemia
  • diamond-blackfan anemia 1
- elite association - COSMIC cancer census association via MalaCards
Search RPS3A in MalaCards View complete list of genes associated with diseases

Relevant External Links for RPS3A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPS3A
genes like me logo Genes that share disorders with RPS3A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS3A Gene

Publications for RPS3A Gene

  1. The human S3a ribosomal protein: sequence, location and cell-free transcription of the functional gene. (PMID: 8647443) Nolte D. … Seifart K.H. (Gene 1996) 2 3 4 22 64
  2. Human ribosomal protein S3a: cloning of the cDNA and primary structure of the protein. (PMID: 1398113) Metspalu A. … Kruppa J. (Gene 1992) 2 3 4 22 64
  3. Molecular composition of IMP1 ribonucleoprotein granules. (PMID: 17289661) Joeson L. … Nielsen F.C. (Mol. Cell. Proteomics 2007) 3 4 64
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64

Products for RPS3A Gene

Sources for RPS3A Gene

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