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Aliases for RPS3 Gene

Aliases for RPS3 Gene

  • Ribosomal Protein S3 2 3 5
  • IMR-90 Ribosomal Protein S3 2 3
  • 40S Ribosomal Protein S3 2 3
  • EC 4.2.99.18 4
  • S3 3

External Ids for RPS3 Gene

Previous GeneCards Identifiers for RPS3 Gene

  • GC11P077437
  • GC11P076649
  • GC11P074836
  • GC11P074788
  • GC11P075110
  • GC11P071407

Summaries for RPS3 Gene

Entrez Gene Summary for RPS3 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit, where it forms part of the domain where translation is initiated. The protein belongs to the S3P family of ribosomal proteins. Studies of the mouse and rat proteins have demonstrated that the protein has an extraribosomal role as an endonuclease involved in the repair of UV-induced DNA damage. The protein appears to be located in both the cytoplasm and nucleus but not in the nucleolus. Higher levels of expression of this gene in colon adenocarcinomas and adenomatous polyps compared to adjacent normal colonic mucosa have been observed. This gene is co-transcribed with the small nucleolar RNA genes U15A and U15B, which are located in its first and fifth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for RPS3 Gene

RPS3 (Ribosomal Protein S3) is a Protein Coding gene. Diseases associated with RPS3 include Eumycotic Mycetoma and Dermatomycosis. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Metabolism. GO annotations related to this gene include poly(A) RNA binding and protein kinase binding.

UniProtKB/Swiss-Prot for RPS3 Gene

  • Involved in translation as a component of the 40S small ribosomal subunit (PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571). Enhances the uracil excision activity of UNG1 (PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (PubMed:17049931). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (PubMed:18045535). Represses its own translation by binding to its cognate mRNA (PubMed:20217897). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (PubMed:23131551). Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (PubMed:22510408).

Gene Wiki entry for RPS3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS3 Gene

Genomics for RPS3 Gene

Regulatory Elements for RPS3 Gene

Enhancers for RPS3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F075398 1.1 ENCODE 17.4 +1.8 1806 4.8 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 SERPINH1 KLHL35 POLD3 RNF169 RPS3 ENSG00000254460 ENSG00000254630 OR2AT1P LOC283214 ENSG00000254837
GH11F075417 0.8 Ensembl ENCODE 17.1 +21.4 21431 6.6 PKNOX1 MLX ARID4B SIN3A YY1 GATA2 FOS SP5 SMARCA4 KDM1A KLHL35 RPS3 ENSG00000254837 GC11M075423 SNORD15B
GH11F075379 0.6 Ensembl ENCODE 13.5 -16.9 -16906 5.3 HDGF PKNOX1 ZFP64 ARID4B ZNF48 ZNF2 ZNF143 DEK MIER2 REST ARRB1 RPS3 MIR326 SNORD15B KLHL35 GDPD5 LOC105369391
GH11F075375 0.7 Ensembl 13.1 -23.3 -23286 0.8 CTCF SAP130 RAD21 NR2F6 ZSCAN29 GATAD2A SMARCA5 L3MBTL2 HLF NR2F1 RPS3 ARRB1
GH11F075370 1.2 FANTOM5 Ensembl ENCODE 12.3 -29.5 -29453 1.3 ARID1B BCOR ZNF146 ZMYM3 KDM1A NR3C1 RPS3 NEU3 ARRB1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RPS3 on UCSC Golden Path with GeneCards custom track

Promoters for RPS3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000565483 814 2201 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for RPS3 Gene

Chromosome:
11
Start:
75,399,486 bp from pter
End:
75,422,302 bp from pter
Size:
22,817 bases
Orientation:
Plus strand

Genomic View for RPS3 Gene

Genes around RPS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS3 Gene

Proteins for RPS3 Gene

  • Protein details for RPS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23396-RS3_HUMAN
    Recommended name:
    40S ribosomal protein S3
    Protein Accession:
    P23396
    Secondary Accessions:
    • B2R7N5
    • J3KN86
    • Q498B5
    • Q8NI95

    Protein attributes for RPS3 Gene

    Size:
    243 amino acids
    Molecular mass:
    26688 Da
    Quaternary structure:
    • Component of the 40S small ribosomal subunit (PubMed:8706699). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661). Interacts with HNRPD (PubMed:24423872). Interacts with PRMT1; the interaction methylates RPS3 (PubMed:19460357). Interacts with SUMO1; the interaction sumoylates RPS3 (PubMed:21968017). Interacts with UBC9 (PubMed:21968017). Interacts with CDK1; the interaction phosphorylates RPS3 (PubMed:21871177). Interacts with PRKCD; the interaction phosphorylates RPS3 (PubMed:19059439). Interacts with PKB/AKT; the interaction phosphorylates RPS3 (PubMed:20605787). Interacts with E2F1; the interaction occurs in the absence of nerve growth factor and increases transcription of pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with the base excision repair proteins APEX1 and OGG1; interaction with OGG1 increases OGG1 N-glycosylase activity (PubMed:15518571). Interacts with UNG; the interaction increases the uracil excision activity of UNG1 (PubMed:18973764). Interacts with HSP90; the interaction prevents the ubiquitination and proteasome-dependent degradation of RPS3 and is suppressed by increased ROS levels (PubMed:16314389). Interacts with TOM70; the interaction promotes translocation of RPS3 to the mitochondrion (PubMed:23911537). Interacts (via N-terminus) with RELA (via N-terminus); the interaction enhances the DNA-binding activity of the NF-kappa-B p65-p50 complex (PubMed:18045535). Interacts with NFKBIA; the interaction is direct and may bridge the interaction between RPS3 and RELA (PubMed:24457201). Interacts with IKKB; the interaction phosphorylates RPS3 and enhances its translocation to the nucleus (PubMed:21399639). Interacts (via KH domain) with MDM2 and TP53 (PubMed:19656744). Interacts with TRADD (PubMed:22510408). Interacts (via N-terminus) with E.coli O157:H7 (strain EDL933) nleH1 and nleH2; the interaction with nleH1 inhibits phosphorylation by IKKB, reduces RPS3 nuclear abundance and inhibits transcriptional activation by the NF-kappa-B p65-p50 complex (PubMed:20041225, PubMed:21399639). Identified in a HCV IRES-mediated translation complex, at least composed of EIF3C, IGF2BP1, RPS3 and HCV RNA-replicon (PubMed:19541769). Interacts with CRY1 (By similarity).
    SequenceCaution:
    • Sequence=BAB93471.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPS3 Gene

    Alternative splice isoforms for RPS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPS3 Gene

Post-translational modifications for RPS3 Gene

  • Methylation by PRMT1 is required for import into the nucleolus and for ribosome assembly.
  • Phosphorylation at Thr-221 by CDK1 occurs mainly in G2/M phase (PubMed:21871177). Phosphorylation by PRKCD occurs on a non-ribosomal-associated form which results in translocation of RPS3 to the nucleus and enhances its endonuclease activity (PubMed:19059439). Phosphorylated on Ser-209 by IKKB in response to activation of the NF-kappa-B p65-p50 complex which enhances the association of RPS3 with importin-alpha and mediates the nuclear translocation of RPS3 (PubMed:21399639). Phosphorylation by MAPK is required for translocation to the nucleus following exposure of cells to DNA damaging agents such as hydrogen peroxide (PubMed:17560175). Phosphorylation by PKB/AKT mediates RPS3 nuclear translocation, enhances RPS3 endonuclease activity and suppresses RPS3-induced neuronal apoptosis (PubMed:20605787).
  • Sumoylation by SUMO1 enhances protein stability through increased resistance to proteolysis. Sumoylation occurs at one or more of the three consensus sites, Lys-18, Lys-214 and Lys-230.
  • Ubiquitinated. This is prevented by interaction with HSP90 which stabilizes the protein.
  • Ubiquitination at Lys 7, Lys 10, Lys 18, Lys 62, Lys 75, Lys 90, Lys 108, Lys 132, Lys 141, Lys 151, Lys 187, Lys 197, Lys 201, Lys 202, Lys 214, and Lys 230
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RPS3 (RPS3)

No data available for DME Specific Peptides for RPS3 Gene

Domains & Families for RPS3 Gene

Gene Families for RPS3 Gene

Suggested Antigen Peptide Sequences for RPS3 Gene

Graphical View of Domain Structure for InterPro Entry

P23396

UniProtKB/Swiss-Prot:

RS3_HUMAN :
  • Contains 1 KH type-2 domain.
  • Belongs to the ribosomal protein S3P family.
Domain:
  • Contains 1 KH type-2 domain.
Family:
  • Belongs to the ribosomal protein S3P family.
genes like me logo Genes that share domains with RPS3: view

Function for RPS3 Gene

Molecular function for RPS3 Gene

GENATLAS Biochemistry:
40S ribosomal protein S3,26kDa (see RNU15A),invvolved in the repair of oxidative DNA lesions,not overexpressed in Fanconi anemia
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is between 8.0 and 9.0 with activity decreasing sharply below 8.0. {ECO:0000269 PubMed:15707971};
UniProtKB/Swiss-Prot CatalyticActivity:
The C-O-P bond 3 to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3-terminal unsaturated sugar and a product with a terminal 5-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Endonuclease activity is inhibited by MgCl2 on apurinic/apyrimidinic DNA but not on UV-irradiated DNA.
UniProtKB/Swiss-Prot Function:
Involved in translation as a component of the 40S small ribosomal subunit (PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571). Enhances the uracil excision activity of UNG1 (PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (PubMed:17049931). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (PubMed:18045535). Represses its own translation by binding to its cognate mRNA (PubMed:20217897). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (PubMed:23131551). Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (PubMed:22510408).

Enzyme Numbers (IUBMB) for RPS3 Gene

Gene Ontology (GO) - Molecular Function for RPS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA,IDA 18610840
GO:0003684 damaged DNA binding IDA 14706345
GO:0003723 RNA binding IEA,IDA 20217897
GO:0003729 mRNA binding IDA 18464793
GO:0003735 structural constituent of ribosome IEA,NAS 1712897
genes like me logo Genes that share ontologies with RPS3: view
genes like me logo Genes that share phenotypes with RPS3: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS3 Gene

Localization for RPS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS3 Gene

Cytoplasm. Nucleus. Nucleus, nucleolus. Mitochondrion inner membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, spindle. Note=In normal cells, located mainly in the cytoplasm with small amounts in the nucleus but translocates to the nucleus in cells undergoing apoptosis (By similarity). Nuclear translocation is induced by DNA damaging agents such as hydrogen peroxide (PubMed:17560175). Accumulates in the mitochondrion in response to increased ROS levels (PubMed:23911537). Localizes to the spindle during mitosis (PubMed:23131551). Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:17289661). {ECO:0000250 UniProtKB:P62908, ECO:0000269 PubMed:17289661, ECO:0000269 PubMed:17560175, ECO:0000269 PubMed:23131551, ECO:0000269 PubMed:23911537}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS3 Gene COMPARTMENTS Subcellular localization image for RPS3 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
mitochondrion 5
nucleus 5
plasma membrane 5
chloroplast 2

Gene Ontology (GO) - Cellular Components for RPS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IMP 21399639
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA,IDA 19460357
GO:0005737 cytoplasm IMP 21871177
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with RPS3: view

Pathways & Interactions for RPS3 Gene

SuperPathways for RPS3 Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
.55
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing in the nucleus and cytosol
5 HIV Life Cycle
.45
genes like me logo Genes that share pathways with RPS3: view

Pathways by source for RPS3 Gene

SIGNOR curated interactions for RPS3 Gene

Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for RPS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006281 DNA repair IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006364 rRNA processing TAS --
genes like me logo Genes that share ontologies with RPS3: view

Drugs & Compounds for RPS3 Gene

(2) Drugs for RPS3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with RPS3: view

Transcripts for RPS3 Gene

Unigene Clusters for RPS3 Gene

Ribosomal protein S3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b
SP1: - -
SP2: -
SP3: - - - - -
SP4: - - - - -
SP5: - - - -
SP6: - - -
SP7: - -
SP8: - - -
SP9: - - - - - -
SP10: -
SP11: - - - -

Relevant External Links for RPS3 Gene

GeneLoc Exon Structure for
RPS3
ECgene alternative splicing isoforms for
RPS3

Expression for RPS3 Gene

mRNA expression in normal human tissues for RPS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPS3 Gene

This gene is overexpressed in Tlymphocyte (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPS3 Gene



Protein tissue co-expression partners for RPS3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS3 Gene:

RPS3

SOURCE GeneReport for Unigene cluster for RPS3 Gene:

Hs.546286
genes like me logo Genes that share expression patterns with RPS3: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS3 Gene

Orthologs for RPS3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPS3 34 35
  • 99.73 (n)
oppossum
(Monodelphis domestica)
Mammalia RPS3 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RPS3 34 35
  • 94.38 (n)
dog
(Canis familiaris)
Mammalia RPS3 34 35
  • 93.96 (n)
rat
(Rattus norvegicus)
Mammalia Rps3 34
  • 90.67 (n)
mouse
(Mus musculus)
Mammalia Rps3 34 16 35
  • 90.26 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RPS3 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPS3 34 35
  • 83.13 (n)
lizard
(Anolis carolinensis)
Reptilia RPS3 35
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rps3 34
  • 84.22 (n)
MGC75699 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.6 34
zebrafish
(Danio rerio)
Actinopterygii rps3 34 35
  • 82.03 (n)
zgc56088 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10138 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001910 34
  • 72.68 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpS3 36 34 35
  • 71.01 (n)
worm
(Caenorhabditis elegans)
Secernentea rps-3 36 34 35
  • 65.81 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL138W 34
  • 62.66 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D08305g 34
  • 62.15 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS3 34 35 37
  • 60.9 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G31610 34
  • 72.22 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1623 34
rice
(Oryza sativa)
Liliopsida Os03g0577000 34
  • 71.14 (n)
Os.21763 34
barley
(Hordeum vulgare)
Liliopsida Hv.3071 34
wheat
(Triticum aestivum)
Liliopsida Ta.14274 34
corn
(Zea mays)
Liliopsida Zm.5498 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5631 35
  • 79 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU00489 34
  • 66.67 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps3 34
  • 65.91 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8884 34
Species where no ortholog for RPS3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPS3 Gene

ENSEMBL:
Gene Tree for RPS3 (if available)
TreeFam:
Gene Tree for RPS3 (if available)

Paralogs for RPS3 Gene

No data available for Paralogs for RPS3 Gene

Variants for RPS3 Gene

Sequence variations from dbSNP and Humsavar for RPS3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10047443 -- 75,419,079(+) AGGGG(G/T)TGGGT intron-variant
rs10501422 -- 75,402,894(+) CAAAT(C/G)TGCTT intron-variant, upstream-variant-2KB
rs10604801 -- 75,412,799(+) TGACA(-/CA)GAGTC intron-variant
rs10793118 -- 75,415,686(+) CTGTA(A/G)TTCCA intron-variant
rs10899088 -- 75,409,392(+) CTTAA(C/T)GAGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPS3 Gene

Variant ID Type Subtype PubMed ID
nsv825995 CNV gain 20364138

Variation tolerance for RPS3 Gene

Residual Variation Intolerance Score: 45.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.46; 43.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS3 Gene

Human Gene Mutation Database (HGMD)
RPS3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS3 Gene

Disorders for RPS3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RPS3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
eumycotic mycetoma
  • eumycetoma
dermatomycosis
  • dermatomycoses
- elite association - COSMIC cancer census association via MalaCards
Search RPS3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RPS3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPS3
genes like me logo Genes that share disorders with RPS3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS3 Gene

Publications for RPS3 Gene

  1. Ribosomal protein genes are overexpressed in colorectal cancer: isolation of a cDNA clone encoding the human S3 ribosomal protein. (PMID: 1712897) Pogue-Geile K. … Pipas J.M. (Mol. Cell. Biol. 1991) 2 3 4 22 64
  2. RpS3 translation is repressed by interaction with its own mRNA. (PMID: 20217897) Kim H.D. … Kim J. (J. Cell. Biochem. 2010) 3 4 22 64
  3. PKCdelta-dependent functional switch of rpS3 between translation and DNA repair. (PMID: 19059439) Kim T.S. … Kim J. (Biochim. Biophys. Acta 2009) 3 4 22 64
  4. Arginine methylation of ribosomal protein S3 affects ribosome assembly. (PMID: 19460357) Shin H.S. … Kim J. (Biochem. Biophys. Res. Commun. 2009) 3 4 22 64
  5. Bacterial effector binding to ribosomal protein s3 subverts NF-kappaB function. (PMID: 20041225) Gao X. … Hardwidge P.R. (PLoS Pathog. 2009) 3 4 22 64

Products for RPS3 Gene

Sources for RPS3 Gene

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