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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPS3 Gene

protein-coding   GIFtS: 65
GCID: GC11P075110

ribosomal protein S3
 Explore 18 diseases affiliated with
RPS3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RPS3    

Aliases
for RPS3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ribosomal Protein S31 2     MGC878701
S31 2     40S Ribosomal Protein S32
FLJ262831     IMR-90 Ribosomal Protein S32
FLJ274501     

External Ids:    HGNC: 104201   Entrez Gene: 61882   Ensembl: ENSG000001492737   OMIM: 6004545   UniProtKB: P233963   

Export aliases for RPS3 gene to outside databases

Previous GC identifers: GC11P077437 GC11P076649 GC11P075333 GC11P074836 GC11P074788 GC11P071407


Summaries
for RPS3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RPS3:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene
encodes a ribosomal protein that is a component of the 40S subunit, where it forms part of the domain where
translation is initiated. The protein belongs to the S3P family of ribosomal proteins. Studies of the mouse and rat
proteins have demonstrated that the protein has an extraribosomal role as an endonuclease involved in the repair of
UV-induced DNA damage. The protein appears to be located in both the cytoplasm and nucleus but not in the nucleolus.
Higher levels of expression of this gene in colon adenocarcinomas and adenomatous polyps compared to adjacent normal
colonic mucosa have been observed. This gene is co-transcribed with the small nucleolar RNA genes U15A and U15B, which
are located in its first and fifth introns, respectively. As is typical for genes encoding ribosomal proteins, there
are multiple processed pseudogenes of this gene dispersed through the genome. Multiple alternatively spliced
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, May 2012)

Gene Wiki entry for RPS3


Genomic Views
for RPS3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPS3 gene promoter:
         Max1   USF1   FAC1   AML1a   USF-1   c-Myb   MyoD   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RPS3 promoter sequence
   Search SABiosciences Chromatin IP Primers for RPS3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.3-q13.5   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q13.3-q13.5

RPS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P075110:  view genomic region     (about GC identifiers)

Start:
 75,110,530 bp from pter      End:
 75,133,324 bp from pter
Size:
 22,795 bases      Orientation:
 plus strand

Proteins
for RPS3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RS3_HUMAN, P23396 (See protein sequence)
Recommended Name: 40S ribosomal protein S3  
Size: 243 amino acids; 26688 Da
Subunit: Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1,
HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0,
RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Identified in a HCV IRES-mediated
translation complex, at least composed of EIF3C, IGF2BP1, RPS3 and HCV RNA-replicon
Subcellular location: Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs
Sequence caution: Sequence=BAB93471.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for RPS3:
1WH9 (3D)    
Secondary accessions: B2R7N5 Q498B5 Q8NI95

Explore the universe of human proteins at neXtProt for RPS3: NX_P23396

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P23396

    • RPS3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_000996.2  NP_001243731.1  NP_001247435.1  NP_001247436.1  

    ENSEMBL proteins: 
     ENSP00000434643   ENSP00000432542   ENSP00000433155   ENSP00000433354   ENSP00000432458  
     ENSP00000416745   ENSP00000278572   ENSP00000431834   ENSP00000436335   ENSP00000436971  
     ENSP00000433421   ENSP00000435457   ENSP00000433821   ENSP00000431737   ENSP00000435566  
     ENSP00000436556   ENSP00000436476   ENSP00000437105  
    Reactome Protein details: P23396
    Human Recombinant Protein Products: 
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    ProSpec Recombinant Protein for RPS3
    Uscn Proteins for RPS3

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA18045535
    GO:0005737cytoplasm IDA14988002
    GO:0005829cytosol TAS--
    GO:0005840ribosome ----
    GO:0015935small ribosomal subunit ----


    RPS3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for RPS3

    Protein Domains /
    Families
    for RPS3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RPS3 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR009019 KH_prok-type
     IPR001351 Ribosomal_S3_C
     IPR018280 Ribosomal_S3_CS
     IPR004044 KH_dom_type_2
     IPR004087 KH_dom

    Graphical View of Domain Structure for InterPro Entry P23396

    ProtoNet protein and cluster: P23396

    2 Blocks protein families:
    IPB001351 Ribosomal protein S3
    IPB004087 KH domain


    UniProtKB/Swiss-Prot: RS3_HUMAN, P23396
    Similarity: Belongs to the ribosomal protein S3P family
    Similarity: Contains 1 KH type-2 domain


    Function
    for RPS3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:
         Genatlas biochemistry entry for RPS3:
    40S ribosomal protein S3,26kDa (see RNU15A),invvolved in the repair of oxidative DNA lesions,not overexpressed in
    Fanconi anemia

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for RPS3

    In Situ Assay
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    Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003684damaged DNA binding IDA16737853
    GO:0003723RNA binding ----
    GO:0003729mRNA binding IDA18464793
    GO:0003735structural constituent of ribosome NAS1712897
    GO:0003906DNA-(apurinic or apyrimidinic site) lyase activity IDA16737853


    RPS3 for ontologies           About GeneDecksing


    7 GenomeRNAi human phenotypes for RPS3:
     Cytoplasmic 40S maturation def  Decreased cell number, increas  Decreased influenza A/WSN/33 r  Decreased viability 
     Decreased viability of wild-ty  Nucleolar pre-40S maturation d  S arrest 


    Pathways & Interactions
    for RPS3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Synthesis of PB1-F2
    8/26 pathways (see all 26)
    		Viral Protein Synthesis1.00
    		Cytoplasmic Ribosomal Proteins0.86
    		Viral mRNA Translation1.00
    		CFTR translational fidelity (class I mutations)0.83
    		Influenza Viral RNA Transcription and Replication1.00
    		SMG6 Cleaves mRNA with Premature Termination Codon0.80
    		Synthesis of nascent polypeptide containing signal sequence1.00
    		L13a-mediated translational silencing of Ceruloplasmin expression0.79
    2Translation initiation complex formation
    		Translation initiation complex formation1.00
    		Ribosomal scanning and start codon recognition0.96
    		Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.98
    		Formation of the ternary complex, and subsequently, the 43S complex0.87
    3Metabolism of mRNA
    		Metabolism of mRNA1.00
    		Metabolism of RNA0.92
    4Translational Control
    		Translational Control1.00
    5Disease
    		Disease1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for RPS3
        Translational Control

    1 GeneGo (Thomson Reuters) Pathway for RPS3
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPS3 
        Cytoplasmic Ribosomal Proteins

    5/32        Reactome Pathways for RPS3 (see all 32)
        Formation of a pool of free 40S subunits
    Synthesis of PB1-F2
    SMG6 Cleaves mRNA with Premature Termination Codon
    Influenza Life Cycle
    Viral mRNA Translation


    1         Kegg Pathway  (Kegg details for RPS3):
        Ribosome


    RPS3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RPS3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/1166 Interacting proteins for RPS3 (P233961, 2, 3 ENSP000002785724) via UniProtKB, MINT, STRING, and/or I2D (see all 1166)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628052, 3MINT-7899812 I2D: score=2 
    HIST1H4BP628052, 3MINT-7899812 I2D: score=2 
    HIST1H4CP628052, 3MINT-7899812 I2D: score=2 
    HIST1H4DP628052, 3MINT-7899812 I2D: score=2 
    HIST1H4EP628052, 3MINT-7899812 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--
    GO:0006415translational termination TAS--


    RPS3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RPS3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RPS3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RPS3
    2 Novoseek chemical compound relationships for RPS3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nadh 26.9 3 12679003 (1), 7545979 (1)
    arginine 6.98 1 19460357 (1)

    Search CenterWatch for drugs/clinical trials and news about RPS3 / RS3 

    Transcripts
    for RPS3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RPS3 gene (4 alternative transcripts): 
    NM_001005.4  NM_001256802.1  NM_001260506.1  NM_001260507.1  

    Unigene Cluster for RPS3:

    Ribosomal protein S3
    Hs.546286  [show with all ESTs]
    Unigene Representative Sequence: NM_001260506
    18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000531188(uc001owh.3) ENST00000529173 ENST00000531810 ENST00000528439
    ENST00000530164(uc001owg.3) ENST00000530689 ENST00000530721 ENST00000422465
    ENST00000278572 ENST00000532872 ENST00000534440 ENST00000527446 ENST00000526608
    ENST00000527273 ENST00000524851 ENST00000526248 ENST00000529285 ENST00000534555


    miRNA
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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AB062288.1 AK223048.1 AK313051.1 BC003137.1 BC003577.1 BC013196.1 BC013231.1 BC029981.1 
    BC034149.1 BC071917.1 BC100284.1 BC150501.1 S42658.1 U14990.1 U14991.1 U14992.1 
    X55715.1 

    24/127 DOTS entries (see all 127):

    DT.92473500  DT.95266276  DT.99926512  DT.97869257  DT.91966371  DT.100729297  DT.100729300  DT.86996332 
    DT.100729295  DT.100729283  DT.100857373  DT.92473333  DT.98084082  DT.95076748  DT.92473381  DT.100729312 
    DT.100871291  DT.100729308  DT.92473562  DT.92473542  DT.120722678  DT.95266203  DT.97851716  DT.100729317 

    24/2409 AceView cDNA sequences (see all 2409):

    BU194462 BQ052366 U14990 CR611679 BU736287 BU149084 AI193324 CR598363 
    CR610850 BM311660 BQ954800 BQ645141 BI193124 BU178031 AI434096 CF130451 
    BU956604 BU902286 BQ061555 BM558829 AA381480 BQ959439 BU731738 BQ212887 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for RPS3 (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b
    SP1:                                                  -                 -                                       
    SP2:                                                                    -                                       
    SP3:                                                  -           -     -     -     -                           
    SP4:              -     -     -                       -                 -                                       
    SP5:                                                  -     -     -     -                                       


    ECgene alternative splicing isoforms for RPS3

    Expression
    for RPS3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPS3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCCCAGCCAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RPS3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Endoderm-like cells (Generation of hepato...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RPS3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPS3

    SOURCE GeneReport for Unigene cluster: Hs.546286
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    In Situ
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    Orthologs
    for RPS3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPS3 gene from 10/42 species (see all 42)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rps31 , 5 ribosomal protein S31, 5 90.26(n)1
    99.59(a)1    		   7 (54.07 cM)5
    270501  NM_012052.21  NP_036182.11 
     994778965 
    chicken
    (Gallus gallus)    		 Aves RPS31 ribosomal protein S3 83.13(n)
    97.94(a)    		   419069  NM_001030836.1  NP_001026007.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RPS36
    		 --
    		 98(a)
    		 1 ↔ 1
    		 GL343298.1(701409-709196)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.62 X.laevis mRNA for ribosomal protein S1a 84.28(n)    BC042230.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc560882 similar to 40S ribosomal protein S3 82.24(n)   394128  AY394937.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta RpS31 , 3 protein biosynthesis DNA-(apurinic or
    apyrimidinic more3
    Ribosomal protein S31    		 83(a)3
    71.01(n)1
    83.91(a)1    		   3 94E133
    427611  NM_057284.41  NP_476632.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea rps-31 , 3 Ribosomal protein S33
    Protein RPS-31    		 76(a)3
    65.95(n)1
    75.97(a)1    		   III(6278589-6279694)3
    1758791  NM_065948.31  NP_498349.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes RPS3(YNL178W)4
    RPS31    		 Protein component of the small (40S) ribosomal subunit, more4
    Rps3p1    		 59.8(n)1
    65.97(a)1    		   14(302680-303402)4
    8555431, 4  NP_014221.31  NP_014221.14 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT2G316101 40S ribosomal protein S3-1 72.22(n)
    81.98(a)    		   817719  NM_128718.4  NP_180719.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.217632 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.16(n)    AK061051.1 


    ENSEMBL Gene Tree for RPS3 (if available)
    TreeFam Gene Tree for RPS3 (if available) 

    Paralogs
    for RPS3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPS3 gene

    RPS3 for paralogs           About GeneDecksing


    5/10 Pseudogenes.org Pseudogenes for RPS3 (see all 10)
    PGOHUM00000257942 PGOHUM00000249177 PGOHUM00000234961 PGOHUM00000258112 PGOHUM00000258113


    Genomic Variants
    for RPS3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/383 NCBI SNPs in RPS3 are shown (see all 383)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1447282691,2
    		--75108549(+) GCTCAC/GGCCTG 4 -- us2k10--------
    rs1883482061,2
    		--75108577(+) GAGGCC/TGAGGT 4 -- us2k10--------
    rs1491563291,2
    		C,--75108610(+) TTCAAG/AACAAG 4 -- us2k11Minor allele frequency- A:0.01NS 150
    rs1858318121,2
    		--75108643(+) TATCTC/GTACTA 4 -- us2k10--------
    rs1432499321,2
    		C,--75108656(+) AATATG/CAAAAT 4 -- us2k11Minor allele frequency- C:0.01NS 150
    rs1899077181,2
    		--75108676(+) ATGGCA/GGTGCT 4 -- us2k10--------
    rs1120806541,2
    		C,--75108681(+) GGTGCT/GTGCCT 4 -- us2k13Minor allele frequency- G:0.01CSA NA NS 272
    rs1433520381,2
    		C,F,--75108726(+) AATCGC/TTTGAA 4 -- us2k11Minor allele frequency- T:0.01NS 150
    rs1868067631,2
    		--75108764(+) GCGATC/TGCACC 4 -- us2k10--------
    rs1439768141,2
    		--75108841(+) ACTGTC/TATTGA 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for RPS3 (75110530 - 75133324 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RPS3: --
    Human Gene Mutation Database (HGMD): RPS3

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPS3
    DNA2.0 Custom Variant and Variant Library Synthesis for RPS3

    Disorders / Diseases
    for RPS3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RPS3 for disorders           About GeneDecksing

    OMIM gene information: 600454    OMIM disorders: --

    18 diseases for RPS3:    About MalaCards
    adenocarcinoma    eumycotic mycetoma    colon adenocarcinoma    mycetoma
    fanconi's anemia    squamous cell carcinoma    conjunctivitis    fibrosarcoma
    anemia    lung adenocarcinoma    colorectal cancer    prostate cancer
    breast cancer    pneumonia    leukemia    prostatitis
    carcinoma    malaria

    1 disease from the University of Copenhagen DISEASES database for RPS3:
    Eumycotic mycetoma

    3 Novoseek disease relationships for RPS3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 0 1 12697126 (1)
    adenocarcinoma 0 1 11948124 (1)
    cancer 0 1 12679003 (1)


    Export disorders for RPS3 gene to outside databases

    Publications
    for RPS3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPS3 gene, integrated from 9 sources (see all 151):
    (articles sorted by number of sources associating them with RPS3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Ribosomal protein genes are overexpressed in colorectal cancer: isolation of a cDNA clone encoding the human S3 ribosomal protein. (PubMed id 1712897)1, 2, 3, 9 Pogue-Geile K.... Pipas J.M. (1991)
    2. Mapping of ribosomal protein S3 and internally nested snoRNA U15A gene to human chromosome 11q13.3-q13.5. (PubMed id 7789996)1, 3, 9 Polakiewicz R.D....Page D.C. (1995)
    3. A small nucleolar RNA is processed from an intron of the human gene encoding ribosomal protein S3. (PubMed id 8319909)1, 2, 9 Tycowski K.T.... Steitz J.A. (1993)
    4. Isolation of a cDNA encoding human 40S ribosomal protein s3. (PubMed id 2129557)1, 2, 9 Zhang X.T.... Tan Y.H. (1990)
    5. Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PubMed id 18781797)1, 2 Meierhofer D.... Kaiser P. (2008)
    6. Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)1, 2 Joeson L.... Nielsen F.C. (2007)
    7. Phosphoproteomic analysis of the human pituitary. (PubMed id 16807684)1, 2 Beranova-Giorgianni S.... Giorgianni F. (2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PubMed id 11875025)1, 2 Yoshihama M.... Kenmochi N. (2002)
    10. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699)1, 2 Vladimirov S.N.... Otto A. (1996)

    External Searches for RPS3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RPS3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6188 HGNC: 10420 AceView: RPS3 Ensembl:ENSG00000149273 euGenes: HUgn6188
    ECgene: RPS3 Kegg: 6188 H-InvDB: RPS3

    Other Databases showing RPS3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RPS3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPS3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RPS3 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/rps3/

    Intellectual Property
    for RPS3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RPS3 gene:
    Search GeneIP for patents involving RPS3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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