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RPS3 Gene

protein-coding   GIFtS: 66
GCID: GC11P075110

Ribosomal Protein S3

  See RPS3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribosomal Protein S31 2
40S Ribosomal Protein S31 2
IMR-90 Ribosomal Protein S31 2
S32

External Ids:    HGNC: 104201   Entrez Gene: 61882   Ensembl: ENSG000001492737   OMIM: 6004545   UniProtKB: P233963   

Export aliases for RPS3 gene to outside databases

Previous GC identifers: GC11P077437 GC11P076649 GC11P075333 GC11P074836 GC11P074788 GC11P071407


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RPS3 Gene:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This
gene encodes a ribosomal protein that is a component of the 40S subunit, where it forms part of the domain where
translation is initiated. The protein belongs to the S3P family of ribosomal proteins. Studies of the mouse and
rat proteins have demonstrated that the protein has an extraribosomal role as an endonuclease involved in the
repair of UV-induced DNA damage. The protein appears to be located in both the cytoplasm and nucleus but not in
the nucleolus. Higher levels of expression of this gene in colon adenocarcinomas and adenomatous polyps compared
to adjacent normal colonic mucosa have been observed. This gene is co-transcribed with the small nucleolar RNA
genes U15A and U15B, which are located in its first and fifth introns, respectively. As is typical for genes
encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, May 2012)

GeneCards Summary for RPS3 Gene:
RPS3 (ribosomal protein S3) is a protein-coding gene. Diseases associated with RPS3 include eumycotic mycetoma, and mycetoma. GO annotations related to this gene include mRNA binding and protein kinase binding.

Gene Wiki entry for RPS3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPS3 gene promoter:
         Max1   USF1   FAC1   AML1a   USF-1   c-Myb   MyoD   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPS3 promoter sequence
   Search Chromatin IP Primers for RPS3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPS3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.3-q13.5   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q13.3-q13.5

RPS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P075110:  view genomic region     (about GC identifiers)

Start:
75,110,530 bp from pter      End:
75,133,324 bp from pter
Size:
22,795 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RS3_HUMAN, P23396 (See protein sequence)
Recommended Name: 40S ribosomal protein S3  
Size: 243 amino acids; 26688 Da
Subunit: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Identified in a HCV
IRES-mediated translation complex, at least composed of EIF3C, IGF2BP1, RPS3 and HCV RNA-replicon
Sequence caution: Sequence=BAB93471.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for RPS3:
1WH9 (3D)        3J3A (3D)    
Secondary accessions: B2R7N5 J3KN86 Q498B5 Q8NI95
Alternative splicing: 2 isoforms:  P23396-1   P23396-2   (No experimental confirmation available. Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for RPS3: NX_P23396

Explore proteomics data for RPS3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys7, Lys10, Lys18, Lys62, Lys75, Lys90, Lys108, Lys132, Lys141, Lys151,
                                 Lys187, Lys197, Lys201, Lys202, Lys214, Lys230
  • Modification sites at PhosphoSitePlus

  • See RPS3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_000996.2  NP_001243731.1  NP_001247435.1  NP_001247436.1  

    ENSEMBL proteins: 
     ENSP00000434643   ENSP00000432542   ENSP00000433155   ENSP00000432458   ENSP00000416745  
     ENSP00000278572   ENSP00000431834   ENSP00000436335   ENSP00000436971   ENSP00000433421  
     ENSP00000435457   ENSP00000433821   ENSP00000431737   ENSP00000435566   ENSP00000436556  
     ENSP00000436476   ENSP00000437105  
    Reactome Protein details: P23396

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RPS: S ribosomal proteins

    Selected InterPro protein domains (see all 7):
     IPR009019 KH_prok-type
     IPR001351 Ribosomal_S3_C
     IPR018280 Ribosomal_S3_CS
     IPR004044 KH_dom_type_2
     IPR004087 KH_dom

    Graphical View of Domain Structure for InterPro Entry P23396

    ProtoNet protein and cluster: P23396

    2 Blocks protein domains:
    IPB001351 Ribosomal protein S3
    IPB004087 KH domain


    UniProtKB/Swiss-Prot: RS3_HUMAN, P23396
    Similarity: Belongs to the ribosomal protein S3P family
    Similarity: Contains 1 KH type-2 domain


    Find genes that share domains with RPS3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for RPS3:
    40S ribosomal protein S3,26kDa (see RNU15A),invvolved in the repair of oxidative DNA lesions,not overexpressed in
    Fanconi anemia

         Gene Ontology (GO): Selected molecular function terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003684damaged DNA binding IDA16737853
    GO:0003723RNA binding ----
    GO:0003729mRNA binding IDA18464793
    GO:0003735structural constituent of ribosome NAS1712897
    GO:0003906DNA-(apurinic or apyrimidinic site) lyase activity IDA16737853
         
    Find genes that share ontologies with RPS3           About GenesLikeMe


    Phenotypes:
         7 GenomeRNAi human phenotypes for RPS3:
     Cytoplasmic 40S maturation def  Decreased cell number, increas  Decreased influenza A/WSN/33 r  Decreased viability 
     Decreased viability of wild-ty  Nucleolar pre-40S maturation d  S arrest 

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    miRNA
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    hsa-mir-30c-5p (MIRT047912), hsa-mir-182-5p (MIRT047193), hsa-mir-30e-3p (MIRT044122), hsa-mir-16-5p (MIRT051120), hsa-mir-106b-3p (MIRT038586), hsa-mir-331-3p (MIRT043461), hsa-mir-196b-3p (MIRT035761), hsa-mir-615-3p (MIRT039732), hsa-mir-15b-5p (MIRT046540), hsa-mir-193b-3p (MIRT041288), hsa-mir-324-3p (MIRT042817)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RS3_HUMAN, P23396: Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5
    plasma membrane5
    chloroplast2
    mitochondrion2

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IMP--
    GO:0005737cytoplasm IDA14988002
    GO:0005829cytosol TAS--
    GO:0005840ribosome ----
    GO:0015935small ribosomal subunit ----

    Find genes that share ontologies with RPS3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RPS3 About   (see all 7)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CFTR translational fidelity class I mutations
    CFTR translational fidelity class I mutations 0.60
    Ribosome0.54
    Cytoplasmic Ribosomal Proteins0.60
    2Influenza Viral RNA Transcription and Replication
    Viral mRNA Translation0.94
    Eukaryotic Translation Initiation0.89
    Peptide chain elongation0.94
    Cap-dependent Translation Initiation0.89
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    Formation of a pool of free 40S subunits0.94
    Nonsense-Mediated Decay0.89
    3Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
    Translation initiation complex formation0.91
    Ribosomal scanning and start codon recognition0.91
    Formation of the ternary complex, and subsequently, the 43S complex0.91
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.90
    4Gene Expression
    Gene Expression0.40
    5Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30


    Find genes that share SuperPaths with RPS3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for RPS3
        Translational Control

    1 GeneGo (Thomson Reuters) Pathway for RPS3
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPS3
        Cytoplasmic Ribosomal Proteins


    Selected Reactome Pathways for RPS3 (see all 12)
        Peptide chain elongation
    Formation of the ternary complex, and subsequently, the 43S complex
    Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
    Viral mRNA Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit


    1 Kegg Pathway  (Kegg details for RPS3):
        Ribosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RPS3
    Interactions:

        GeneGlobe Interaction Network for RPS3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPS3 (P233961, 2, 3 ENSP000002785724) via UniProtKB, MINT, STRING, and/or I2D (see all 1285)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628052, 3MINT-7899812 I2D: score=2 
    HIST1H4BP628052, 3MINT-7899812 I2D: score=2 
    HIST1H4CP628052, 3MINT-7899812 I2D: score=2 
    HIST1H4DP628052, 3MINT-7899812 I2D: score=2 
    HIST1H4EP628052, 3MINT-7899812 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0000737DNA catabolic process, endonucleolytic IDA16737853
    GO:0002181cytoplasmic translation IBA--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--

    Find genes that share ontologies with RPS3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPS3 (RS3)

    2 Novoseek inferred chemical compound relationships for RPS3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nadh 26.9 3 12679003 (1), 7545979 (1)
    arginine 6.98 1 19460357 (1)



    Find genes that share compounds with RPS3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RPS3 gene (4 alternative transcripts): 
    NM_001005.4  NM_001256802.1  NM_001260506.1  NM_001260507.1  

    Unigene Cluster for RPS3:

    Ribosomal protein S3
    Hs.546286  [show with all ESTs]
    Unigene Representative Sequence: NM_001260506
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000531188(uc001owh.3) ENST00000529173 ENST00000528439 ENST00000530164(uc001owg.3)
    ENST00000530721 ENST00000422465 ENST00000278572 ENST00000532872 ENST00000534440
    ENST00000527446 ENST00000526608 ENST00000527273 ENST00000524851 ENST00000526248
    ENST00000529285 ENST00000534555 ENST00000528847 ENST00000525933
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    Additional mRNA sequence: 

    AB062288.1 AK223048.1 AK313051.1 BC003137.1 BC003577.1 BC013196.1 BC013231.1 BC029981.1 
    BC034149.1 BC071917.1 BC100284.1 BC150501.1 S42658.1 U14990.1 U14991.1 U14992.1 
    X55715.1 

    Selected DOTS entries (see all 127):

    DT.92473500  DT.95266276  DT.99926512  DT.97869257  DT.91966371  DT.100729297  DT.100729300  DT.86996332 
    DT.100729295  DT.100729283  DT.100857373  DT.92473333  DT.98084082  DT.95076748  DT.92473381  DT.100729312 
    DT.100871291  DT.100729308  DT.92473562  DT.92473542  DT.120722678  DT.95266203  DT.97851716  DT.100729317 

    Selected AceView cDNA sequences (see all 2409):

    BU168397 AI620069 BU184912 BM907647 CR607881 BU553354 BM719040 BM469016 
    BG035471 BU194696 BQ233420 AA700026 BM468120 BQ227612 BM802116 AI879681 
    BU069107 BI711204 BQ683504 BQ675807 BQ056792 BM559378 CA411867 CA843227 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RPS3 (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b
    SP1:                                                  -                 -                                       
    SP2:                                                                    -                                       
    SP3:                                                  -           -     -     -     -                           
    SP4:              -     -     -                       -                 -                                       
    SP5:                                                  -     -     -     -                                       


    ECgene alternative splicing isoforms for RPS3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RPS3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCAGCCAG
    RPS3 Expression
    About this image


    RPS3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Endoderm (Gastrulation Derivatives)
             Endoderm-like cells
     
     Tonsil (Hematopoietic System)
    RPS3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPS3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.546286
        Custom PCR Arrays for RPS3
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPS3 gene from Selected species (see all 30)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rps31 , 5 ribosomal protein S31, 5 90.26(n)1
    99.59(a)1
      7 (54.07 cM)5
    270501  NM_012052.21  NP_036182.11 
     994778965 
    chicken
    (Gallus gallus)
    Aves RPS31 ribosomal protein S3 83.13(n)
    97.94(a)
      419069  NM_001030836.1  NP_001026007.1 
    lizard
    (Anolis carolinensis)
    Reptilia RPS36
    ribosomal protein S3
    98(a)
    1 ↔ 1
    GL343298.1(701102-709200)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.62 X.laevis mRNA for ribosomal protein S1a 84.28(n)    BC042230.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc560882 similar to 40S ribosomal protein S3 82.24(n)   394128  AY394937.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RpS31 , 3 protein biosynthesis DNA-(apurinic or
    apyrimidinic more3
    Ribosomal protein S31
    83(a)3
    71.01(n)1
    83.91(a)1
      3 94E133
    427611  NM_057284.51  NP_476632.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rps-31 , 3 Ribosomal protein S33
    rps-31
    76(a)3
    65.81(n)1
    75.64(a)1
      III(6278589-6279694)3
    1758791  NM_065948.41  NP_498349.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPS3(YNL178W)4
    RPS31
    Protein component of the small (40S) ribosomal subunit, more4
    RPS31
    60.9(n)1
    67.09(a)1
      14(302680-303402)4
    8555431, 4  NP_014221.31  NP_014221.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G316101 AT2G31610 72.22(n)
    81.98(a)
      817719  NM_128718.4  NP_180719.1 
    rice
    (Oryza sativa)
    Liliopsida Os.217632 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.16(n)    AK061051.1 


    ENSEMBL Gene Tree for RPS3 (if available)
    TreeFam Gene Tree for RPS3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RPS3 gene

    Find genes that share paralogs with RPS3           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for RPS3 (see all 10)
    PGOHUM00000257942 PGOHUM00000249177 PGOHUM00000234961 PGOHUM00000258112 PGOHUM00000258113


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RPS3 (see all 376)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1447282691,2
    C--75108549(+) GCTCAC/GGCCTG 4 -- us2k10--------
    rs1883482061,2
    --75108577(+) GAGGCC/TGAGGT 4 -- us2k10--------
    rs1491563291,2
    C--75108610(+) TTCAAG/AACAAG 4 -- us2k11Minor allele frequency- A:0.01NS 150
    rs1858318121,2
    --75108643(+) TATCTC/GTACTA 4 -- us2k10--------
    rs1432499321,2
    C--75108656(+) AATATG/CAAAAT 4 -- us2k11Minor allele frequency- C:0.01NS 150
    rs1899077181,2
    --75108676(+) ATGGCA/GGTGCT 4 -- us2k10--------
    rs1120806541,2
    C,F--75108681(+) GGTGCT/GTGCCT 4 -- us2k13Minor allele frequency- G:0.01CSA NA NS 272
    rs1433520381,2
    C,F--75108726(+) AATCGC/TTTGAA 4 -- us2k11Minor allele frequency- T:0.01NS 150
    rs1868067631,2
    --75108764(+) GCGATC/TGCACC 4 -- us2k10--------
    rs1439768141,2
    C--75108841(+) ACTGTC/TATTGA 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for RPS3 (75110530 - 75133324 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RPS3:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1224n71CNV Loss21882294
    nsv897920CNV Loss21882294
    nsv825995CNV Gain20364138

    Human Gene Mutation Database (HGMD): RPS3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RPS3
    DNA2.0 Custom Variant and Variant Library Synthesis for RPS3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600454    OMIM disorders: --

    2 diseases for RPS3:    
    About MalaCards
    eumycotic mycetoma    mycetoma

    1 disease from the University of Copenhagen DISEASES database for RPS3:
    Eumycotic mycetoma

    Find genes that share disorders with RPS3           About GenesLikeMe

    3 Novoseek inferred disease relationships for RPS3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 0 1 12697126 (1)
    adenocarcinoma 0 1 11948124 (1)
    cancer 0 1 12679003 (1)


    Export disorders for RPS3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RPS3 gene, integrated from 10 sources (see all 180):
    (articles sorted by number of sources associating them with RPS3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Ribosomal protein genes are overexpressed in colorectal cancer: isolation of a cDNA clone encoding the human S3 ribosomal protein. (PubMed id 1712897)1, 2, 3, 9 Pogue-Geile K.... Pipas J.M. (Mol. Cell. Biol. 1991)
    2. Mapping of ribosomal protein S3 and internally nested snoRNA U15A gene to human chromosome 11q13.3-q13.5. (PubMed id 7789996)1, 3, 9 Polakiewicz R.D....Page D.C. (Genomics 1995)
    3. A small nucleolar RNA is processed from an intron of the human gene encoding ribosomal protein S3. (PubMed id 8319909)1, 2, 9 Tycowski K.T.... Steitz J.A. (Genes Dev. 1993)
    4. Isolation of a cDNA encoding human 40S ribosomal protein s3. (PubMed id 2129557)1, 2, 9 Zhang X.T.... Tan Y.H. (Nucleic Acids Res. 1990)
    5. Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)1, 2 Joeson L.... Nielsen F.C. (Mol. Cell. Proteomics 2007)
    6. Phosphoproteomic analysis of the human pituitary. (PubMed id 16807684)1, 2 Beranova-Giorgianni S.... Giorgianni F. (Pituitary 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PubMed id 11875025)1, 2 Yoshihama M.... Kenmochi N. (Genome Res. 2002)
    9. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699)1, 2 Vladimirov S.N.... Otto A. (Eur. J. Biochem. 1996)
    10. RpS3 translation is repressed by interaction with its own mRNA. (PubMed id 20217897)1, 9 Kim H.D....Kim J. (J. Cell. Biochem. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6188 HGNC: 10420 AceView: RPS3 Ensembl:ENSG00000149273 euGenes: HUgn6188
    ECgene: RPS3 Kegg: 6188 H-InvDB: RPS3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RPS3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RPS3 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/rps3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RPS3 gene:
    Search GeneIP for patents involving RPS3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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