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Aliases for RPS28 Gene

Aliases for RPS28 Gene

  • Ribosomal Protein S28 2 3
  • 40S Ribosomal Protein S28 2 3
  • DBA15 3
  • S28 3

External Ids for RPS28 Gene

Previous GeneCards Identifiers for RPS28 Gene

  • GC19M008155
  • GC19P008476
  • GC19P008281
  • GC19P008292
  • GC19P008386
  • GC19P008040

Summaries for RPS28 Gene

Entrez Gene Summary for RPS28 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S28E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS28 Gene

RPS28 (Ribosomal Protein S28) is a Protein Coding gene. Diseases associated with RPS28 include pasteurellosis and diamond-blackfan anemia. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for RPS28 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS28 Gene

Genomics for RPS28 Gene

Regulatory Elements for RPS28 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RPS28 Gene

Start:
8,321,158 bp from pter
End:
8,323,340 bp from pter
Size:
2,183 bases
Orientation:
Plus strand

Genomic View for RPS28 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPS28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS28 Gene

Proteins for RPS28 Gene

  • Protein details for RPS28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62857-RS28_HUMAN
    Recommended name:
    40S ribosomal protein S28
    Protein Accession:
    P62857
    Secondary Accessions:
    • P25112

    Protein attributes for RPS28 Gene

    Size:
    69 amino acids
    Molecular mass:
    7841 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS28 Gene

neXtProt entry for RPS28 Gene

Proteomics data for RPS28 Gene at MOPED

Post-translational modifications for RPS28 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPS28 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RPS28 Gene

Domains for RPS28 Gene

Gene Families for RPS28 Gene

HGNC:
  • RPS :S ribosomal proteins

Protein Domains for RPS28 Gene

Suggested Antigen Peptide Sequences for RPS28 Gene

Graphical View of Domain Structure for InterPro Entry

P62857

UniProtKB/Swiss-Prot:

RS28_HUMAN :
  • P62857
Family:
  • Belongs to the ribosomal protein S28e family.
genes like me logo Genes that share domains with RPS28: view

Function for RPS28 Gene

Molecular function for RPS28 Gene

GENATLAS Biochemistry:
60S ribosomal protein S28

Gene Ontology (GO) - Molecular Function for RPS28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA --
GO:0005515 protein binding IPI 25416956
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPS28: view

Phenotypes for RPS28 Gene

genes like me logo Genes that share phenotypes with RPS28: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPS28

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPS28 Gene

Localization for RPS28 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS28 Gene COMPARTMENTS Subcellular localization image for RPS28 gene
Compartment Confidence
cytosol 5
mitochondrion 2
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RPS28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome --
GO:0015935 small ribosomal subunit IDA 15883184
genes like me logo Genes that share ontologies with RPS28: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS28 Gene

Pathways for RPS28 Gene

SuperPathways for RPS28 Gene

Superpath Contained pathways
1 Influenza Viral RNA Transcription and Replication
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 CFTR translational fidelity (class I mutations)
.54
4 Disease
5 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
genes like me logo Genes that share pathways with RPS28: view

Pathways by source for RPS28 Gene

1 KEGG pathway for RPS28 Gene
1 GeneGo (Thomson Reuters) pathway for RPS28 Gene

Gene Ontology (GO) - Biological Process for RPS28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing IMP 18697920
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
genes like me logo Genes that share ontologies with RPS28: view

Transcripts for RPS28 Gene

mRNA/cDNA for RPS28 Gene

Unigene Clusters for RPS28 Gene

Ribosomal protein S28:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPS28

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS28 Gene

No ASD Table

Relevant External Links for RPS28 Gene

GeneLoc Exon Structure for
RPS28
ECgene alternative splicing isoforms for
RPS28

Expression for RPS28 Gene

mRNA expression in normal human tissues for RPS28 Gene

Protein differential expression in normal tissues for RPS28 Gene

This gene is overexpressed in Bone marrow stromal cell (8.2) and Peripheral blood mononuclear cells (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS28 Gene

SOURCE GeneReport for Unigene cluster for RPS28 Gene Hs.153177

genes like me logo Genes that share expressions with RPS28: view

Expression partners for RPS28 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS28 Gene

Orthologs for RPS28 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS28 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPS28 35
  • 93.24 (n)
  • 100 (a)
RPS28 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPS28 35
  • 93.24 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Rps28 35
  • 87.92 (n)
  • 100 (a)
Rps28 16
Rps28 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPS28 35
  • 99.52 (n)
  • 100 (a)
RPS28 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rps28 35
  • 85.99 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia RPS28 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPS28 35
  • 86.47 (n)
  • 100 (a)
RPS28 36
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rps28p9 35
  • 76.81 (n)
  • 94.2 (a)
Str.17156 35
zebrafish
(Danio rerio)
Actinopterygii Dr.24923 35
rps28 35
  • 77.29 (n)
  • 95.65 (a)
rps28 36
  • 96 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.827 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003412 35
  • 73.45 (n)
  • 86.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpS28b 35
  • 71.43 (n)
  • 79.37 (a)
RpS28a 36
  • 77 (a)
OneToMany
RpS28b 36
  • 80 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rps-28 35
  • 72.68 (n)
  • 86.89 (a)
rps-28 36
  • 85 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR261W 35
  • 66.67 (n)
  • 77.42 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F20383g 35
  • 63.68 (n)
  • 74.63 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS28A 35
  • 63.98 (n)
  • 75.81 (a)
RPS28A 36
  • 73 (a)
OneToMany
RPS28B 36
  • 73 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons RPS28 35
  • 68.33 (n)
  • 80 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.2070 35
rice
(Oryza sativa)
Liliopsida Os10g0411700 35
  • 69.23 (n)
  • 78.46 (a)
corn
(Zea mays)
Liliopsida Zm.16049 35
bread mold
(Neurospora crassa)
Ascomycetes NCU05599 35
  • 69.12 (n)
  • 77.94 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps2802 35
  • 64.71 (n)
  • 83.82 (a)
Species with no ortholog for RPS28:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS28 Gene

ENSEMBL:
Gene Tree for RPS28 (if available)
TreeFam:
Gene Tree for RPS28 (if available)

Paralogs for RPS28 Gene

genes like me logo Genes that share paralogs with RPS28: view

No data available for Paralogs for RPS28 Gene

Variants for RPS28 Gene

Structural Variations from Database of Genomic Variants (DGV) for RPS28 Gene

Variant ID Type Subtype PubMed ID
dgv3718n71 CNV Loss 21882294
dgv3719n71 CNV Loss 21882294

Relevant External Links for RPS28 Gene

HapMap Linkage Disequilibrium report
RPS28
Human Gene Mutation Database (HGMD)
RPS28

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for RPS28 Gene

Disorders for RPS28 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for RPS28 Gene in MalaCards »

(2) Diseases for RPS28 Gene including...

(1) University of Copenhagen DISEASES for RPS28 Gene

genes like me logo Genes that share disorders with RPS28: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for RPS28 Gene

Publications for RPS28 Gene

  1. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3 4
  2. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PMID: 11875025) Yoshihama M. … Kenmochi N. (Genome Res. 2002) 3 4
  3. A cDNA sequence of human ribosomal protein, homologue of yeast S28. (PMID: 8415000) Hori N. … Matsubara K. (Nucleic Acids Res. 1993) 2 3
  4. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PMID: 8706699) Vladimirov S.N. … Otto A. (Eur. J. Biochem. 1996) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RPS28 Gene

Sources for RPS28 Gene

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