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Aliases for RPS28 Gene

Aliases for RPS28 Gene

  • Ribosomal Protein S28 2 3 5
  • 40S Ribosomal Protein S28 2
  • DBA15 3
  • S28 3

External Ids for RPS28 Gene

Previous GeneCards Identifiers for RPS28 Gene

  • GC19M008155
  • GC19P008476
  • GC19P008281
  • GC19P008292
  • GC19P008386
  • GC19P008040

Summaries for RPS28 Gene

Entrez Gene Summary for RPS28 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S28E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS28 Gene

RPS28 (Ribosomal Protein S28) is a Protein Coding gene. Diseases associated with RPS28 include Diamond Blackfan Anemia 15 With Mandibulofacial Dysostosis and Diamond-Blackfan Anemia. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPS28 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS28 Gene

Genomics for RPS28 Gene

Regulatory Elements for RPS28 Gene

Enhancers for RPS28 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPS28 on UCSC Golden Path with GeneCards custom track

Promoters for RPS28 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPS28 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPS28 Gene

8,321,158 bp from pter
8,323,340 bp from pter
2,183 bases
Plus strand

Genomic View for RPS28 Gene

Genes around RPS28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS28 Gene

Proteins for RPS28 Gene

  • Protein details for RPS28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    40S ribosomal protein S28
    Protein Accession:
    Secondary Accessions:
    • P25112

    Protein attributes for RPS28 Gene

    69 amino acids
    Molecular mass:
    7841 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS28 Gene

neXtProt entry for RPS28 Gene

Proteomics data for RPS28 Gene at MOPED

Post-translational modifications for RPS28 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPS28 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPS28 Gene

Domains & Families for RPS28 Gene

Gene Families for RPS28 Gene

Protein Domains for RPS28 Gene

Suggested Antigen Peptide Sequences for RPS28 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein S28e family.
  • Belongs to the ribosomal protein S28e family.
genes like me logo Genes that share domains with RPS28: view

Function for RPS28 Gene

Molecular function for RPS28 Gene

GENATLAS Biochemistry:
60S ribosomal protein S28
genes like me logo Genes that share phenotypes with RPS28: view

Human Phenotype Ontology for RPS28 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS28 Gene

Localization for RPS28 Gene

Subcellular locations from

Jensen Localization Image for RPS28 Gene COMPARTMENTS Subcellular localization image for RPS28 gene
Compartment Confidence
cytosol 5
extracellular 5
mitochondrion 2
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RPS28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0022627 cytosolic small ribosomal subunit IDA 8706699
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with RPS28: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS28 Gene

Pathways & Interactions for RPS28 Gene

SuperPathways for RPS28 Gene

Superpath Contained pathways
1 Viral mRNA Translation
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 Infectious disease
5 rRNA processing
genes like me logo Genes that share pathways with RPS28: view

Gene Ontology (GO) - Biological Process for RPS28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006407 rRNA export from nucleus IBA --
GO:0006412 translation IEA,IC 8706699
GO:0006413 translational initiation TAS --
GO:0006415 translational termination TAS --
genes like me logo Genes that share ontologies with RPS28: view

No data available for SIGNOR curated interactions for RPS28 Gene

Drugs & Compounds for RPS28 Gene

No Compound Related Data Available

Transcripts for RPS28 Gene

Unigene Clusters for RPS28 Gene

Ribosomal protein S28:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPS28 Gene

No ASD Table

Relevant External Links for RPS28 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS28 Gene

mRNA expression in normal human tissues for RPS28 Gene

Protein differential expression in normal tissues from HIPED for RPS28 Gene

This gene is overexpressed in Bone marrow stromal cell (8.2) and Peripheral blood mononuclear cells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS28 Gene

SOURCE GeneReport for Unigene cluster for RPS28 Gene Hs.153177

genes like me logo Genes that share expression patterns with RPS28: view

Protein tissue co-expression partners for RPS28 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS28 Gene

Orthologs for RPS28 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS28 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPS28 35
  • 93.24 (n)
  • 100 (a)
RPS28 36
  • 100 (a)
(Canis familiaris)
Mammalia RPS28 35
  • 93.24 (n)
  • 100 (a)
(Mus musculus)
Mammalia Rps28 35
  • 87.92 (n)
  • 100 (a)
Rps28 16
Rps28 36
  • 100 (a)
(Pan troglodytes)
Mammalia RPS28 35
  • 99.52 (n)
  • 100 (a)
RPS28 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rps28 35
  • 85.99 (n)
  • 100 (a)
(Monodelphis domestica)
Mammalia RPS28 36
  • 99 (a)
(Gallus gallus)
Aves RPS28 35
  • 86.47 (n)
  • 100 (a)
RPS28 36
  • 100 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rps28p9 35
  • 76.81 (n)
  • 94.2 (a)
Str.17156 35
(Danio rerio)
Actinopterygii Dr.24923 35
rps28 35
  • 77.29 (n)
  • 95.65 (a)
rps28 36
  • 96 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.827 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003412 35
  • 73.45 (n)
  • 86.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpS28b 35
  • 71.43 (n)
  • 79.37 (a)
RpS28a 36
  • 77 (a)
RpS28b 36
  • 80 (a)
(Caenorhabditis elegans)
Secernentea rps-28 35
  • 72.68 (n)
  • 86.89 (a)
rps-28 36
  • 85 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR261W 35
  • 66.67 (n)
  • 77.42 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F20383g 35
  • 63.68 (n)
  • 74.63 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS28A 35
  • 63.98 (n)
  • 75.81 (a)
RPS28A 36
  • 73 (a)
RPS28B 36
  • 73 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons RPS28 35
  • 68.33 (n)
  • 80 (a)
(Hordeum vulgare)
Liliopsida Hv.2070 35
(Oryza sativa)
Liliopsida Os10g0411700 35
  • 69.23 (n)
  • 78.46 (a)
(Zea mays)
Liliopsida Zm.16049 35
bread mold
(Neurospora crassa)
Ascomycetes NCU05599 35
  • 69.12 (n)
  • 77.94 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps2802 35
  • 64.71 (n)
  • 83.82 (a)
Species with no ortholog for RPS28:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS28 Gene

Gene Tree for RPS28 (if available)
Gene Tree for RPS28 (if available)

Paralogs for RPS28 Gene

genes like me logo Genes that share paralogs with RPS28: view

No data available for Paralogs for RPS28 Gene

Variants for RPS28 Gene

Structural Variations from Database of Genomic Variants (DGV) for RPS28 Gene

Variant ID Type Subtype PubMed ID
dgv3718n71 CNV Loss 21882294
dgv3719n71 CNV Loss 21882294

Variation tolerance for RPS28 Gene

Residual Variation Intolerance Score: 59.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.02; 0.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS28 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for RPS28 Gene

Disorders for RPS28 Gene

MalaCards: The human disease database

(3) MalaCards diseases for RPS28 Gene - From: OMIM, ClinVar, Orphanet, and GeneCards

Disorder Aliases PubMed IDs
diamond blackfan anemia 15 with mandibulofacial dysostosis
  • diamond-blackfan anemia 15, with mandibulofacial dysostosis
diamond-blackfan anemia
  • blackfan - diamond syndrome
pierre robin syndrome
  • pierre robin sequence
- elite association - COSMIC cancer census association via MalaCards
Search RPS28 in MalaCards View complete list of genes associated with diseases


  • Diamond-Blackfan anemia 15, with mandibulofacial dysostosis (DBA15) [MIM:606164]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. {ECO:0000269 PubMed:24942156}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for RPS28

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RPS28: view

No data available for Genatlas for RPS28 Gene

Publications for RPS28 Gene

  1. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3 4 67
  2. A cDNA sequence of human ribosomal protein, homologue of yeast S28. (PMID: 8415000) Hori N. … Matsubara K. (Nucleic Acids Res. 1993) 2 3
  3. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  4. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for RPS28 Gene

Sources for RPS28 Gene