RPS28 Gene
protein-coding GIFtS: 51
GCID: GC19P008386
|
|
ribosomal protein S28
| |
Aliases
for RPS28 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ribosomal Protein S281 2 | | S281 2 | | 40S Ribosomal Protein S282 |
Export aliases for RPS28 gene to outside databasesPrevious GC identifers: GC19M008155 GC19P008476 GC19P008281 GC19P008292 GC19P008040 |
Summaries
for RPS28 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RPS28:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This geneencodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S28E family ofribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there aremultiple processed pseudogenes of this gene dispersed through the genome. (provided by RefSeq, Jul 2008)
Gene Wiki entry for RPS28
|
Genomic Views
for RPS28 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_077812.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RPS28 gene promoter:
Bach1 AML1a Bach2 CUTL1 GATA-2 C/EBPalpha RORalpha1 CHOP-10 HEN1 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for RPS28
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS28 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2RPS28 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P008386: view genomic region
(about GC identifiers)
Start:
|
8,386,384 bp from pter |
End:
|
8,387,809 bp from pter |
Size:
|
1,426 bases |
Orientation:
|
plus strand |
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Proteins
for RPS28 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RS28_HUMAN, P62857 (See
protein sequence)Recommended Name: 40S ribosomal protein S28 Size: 69 amino acids; 7841 Da
Secondary accessions: P25112Explore the universe of human proteins at neXtProt for RPS28: NX_P62857
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P62857
RPS28 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001022.1
ENSEMBL proteins: ENSP00000397872 ENSP00000415944 Reactome Protein details: P62857
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
RPS28 for ontologies About GeneDecksing
RPS28 Antibody Products:
Assay Products for RPS28: |
Protein
Domains /
Families
for RPS28 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RPS28 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P62857ProtoNet protein and cluster: P62857 UniProtKB/Swiss-Prot: RS28_HUMAN, P62857Similarity: Belongs to the ribosomal protein S28e family |
Function
for RPS28 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
Genatlas biochemistry entry for RPS28:60S ribosomal protein S28
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPS28 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPS28
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for RPS28 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS28 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003735 | structural constituent of ribosome |
IEA | -- |
RPS28 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for RPS28:
Animal Models:
1 MGI mutant phenotype (inferred from 2 alleles ) (MGI details for Rps28):
RPS28 for phenotypes About GeneDecksing
|
Pathways & Interactions
for RPS28 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Synthesis of PB1-F2 | | | 2 | Translation initiation complex formation | | | 3 | Metabolism of mRNA | | | 4 | Disease | | | 5 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  GeneGo (Thomson Reuters) Pathway for RPS28
1  BioSystems Pathway for RPS28
5/32 
Reactome Pathways for RPS28 (see all 32)
1 
Kegg Pathway (Kegg details for RPS28):
RPS28 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPS28
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/276 Interacting proteins for RPS28 (P628571, 2, 3 ENSP000003978724) via UniProtKB, MINT, STRING, and/or I2D (see all 276)About this table
Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table
RPS28 for ontologies About GeneDecksing
|
Drugs & Compounds
for RPS28 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RPS28
Search CenterWatch for drugs/clinical trials and news about RPS28 / RS28
|
Transcripts
for RPS28 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RPS28 gene: NM_001031.4 Unigene Clusters for RPS28: Ribosomal protein S28 Hs.153177 [show with all ESTs], Hs.740394 [show with all ESTs]Unigene Representative Sequences: CD048071, CD3874082 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000417088 ENST00000449223(uc002mjn.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPS28 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPS28
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RPS28 (NM_001031) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPS28 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS28 |
Additional cDNA sequence: AK293636.1 AK301638.1 BC000354.1 BC018810.1 BC021239.2 BC070217.1 BC070218.1 L05091.1 U58682.1 24/28 DOTS entries (see all 28): DT.100052497 DT.99949585 DT.100670984 DT.451349 DT.97834548 DT.100700773 DT.120701836 DT.100700774 DT.100700769 DT.100748990 DT.95334037 DT.120701851 DT.95334122 DT.95334140 DT.95334250 DT.100048650 DT.121498047 DT.95202774 DT.101985544 DT.120701844 DT.120701821 DT.120701829 DT.120701832 DT.95334022 24/643 AceView cDNA sequences (see all 643): BU070406 BM875513 AA947517 AA320477 AA295700 AA494331 AI002142 BU783146 BQ218329 AI819509 AI700306 BC021239 AI375717 AW007383 BQ477313 AW137757 BM840734 AI479399 BQ219700 BM090881 BM510958 BM818859 N67181 BM849110
GeneLoc Exon Structure
|
Expression
for RPS28 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RPS28 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACGACACGA
About this image
See RPS28 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RPS28
SOURCE GeneReport for Unigene clusters: Hs.153177 Hs.740394
SABiosciences Custom PCR Arrays for RPS28
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RPS28 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS28 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS28 |
Orthologs
for RPS28 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RPS28 gene from 9/34 species (see all 34) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Rps285 |
ribosomal protein S28 |
-- |
|
17 (17.98 cM) 33819027 |
chicken
(Gallus gallus) |
Aves |
RPS281 |
ribosomal protein S28 |
86.47(n)
100(a) |
|
768930 XM_001231864.2 XP_001231865.2 |
African clawed frog
(Xenopus laevis) |
Amphibia |
480578502 |
-- |
78.28(n) |
|
48057850 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.249232 |
Danio rerio cDNA clone MGC73367 IMAGE4146224, complete more |
77.42(n) |
|
BC059677.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
RpS28b1 |
Ribosomal protein S28b |
71.43(n)
79.37(a) |
|
31897 NM_132340.3 NP_572568.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
rps-281 |
Protein RPS-28 |
72.68(n)
86.89(a) |
|
176975 NM_067714.3 NP_500115.1 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
RPS28A1 |
Rps28ap |
63.98(n)
75.81(a) |
|
854338 NP_014810.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
RPS281 |
40S ribosomal protein S28-2 |
68.33(n)
80(a) |
|
836535 NM_125810.2 NP_201219.1 |
rice
(Oryza sativa) |
Liliopsida |
AA752078.12 |
-- |
95.5(n) |
|
AA752078.1 |
ENSEMBL Gene Tree for RPS28 (if available)
TreeFam Gene Tree for RPS28 (if available) |
Paralogs
for RPS28 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RPS28 gene
RPS28 for paralogs About GeneDecksing
5/11 Pseudogenes.org Pseudogenes for RPS28 (see all 11)
PGOHUM00000250414 PGOHUM00000239788 PGOHUM00000248574 PGOHUM00000248202 PGOHUM00000237260
|
Genomic Variants
for RPS28 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPS28 |
|
Disorders
/ Diseases
for RPS28 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RPS28 for disorders About GeneDecksing
OMIM gene information: 603685
OMIM disorders: --
4  diseases for RPS28: About MalaCardsdiamond-blackfan anemia pasteurellosis anemia malaria
1 disease from the University of Copenhagen DISEASES database for RPS28:Pasteurellosis Export disorders for RPS28 gene to outside databases
|
Publications
for RPS28 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RPS28 gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with RPS28) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A map of 75 human ribosomal protein genes. (PubMed id 9582194)1, 2, 3 Kenmochi N.... Page D.C. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PubMed id 11875025)1, 2 Yoshihama M.... Kenmochi N. (2002)
- Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699)1, 2 Vladimirov S.N.... Otto A. (1996)
- A cDNA sequence of human ribosomal protein, homologue of yeast S28. (PubMed id 8415000)1, 3 Hori N.... Matsubara K. (1993)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
|
External Searches for RPS28 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RPS28 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RPS28 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RPS28 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RPS28 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RPS28 gene:
Search GeneIP for patents involving RPS28
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RPS28 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RPS28 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPS28 | | Browse OriGene genome-wide validated SYBR primer pairs | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RPS28 | | OriGene 3'-UTR Clone for RPS28 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPS28 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPS28 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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