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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPS27L Gene

protein-coding   GIFtS: 52
GCID: GC15M063445

Ribosomal Protein S27-Like

  Search for RPS27L
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ribosomal Protein S27-Like1 2
40S Ribosomal Protein S27-Like2

External Ids:    HGNC: 184761   Entrez Gene: 510652   Ensembl: ENSG000001850887   OMIM: 6120555   UniProtKB: Q71UM53   

Export aliases for RPS27L gene to outside databases

Previous GC identifers: GC15M059232 GC15M056493 GC15M060996 GC15M061161 GC15M061233 GC15M040268


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RPS27L Gene:
This gene encodes a protein sharing 96% amino acid similarity with ribosomal protein S27, which suggests the
encoded protein may be a component of the 40S ribosomal subunit. (provided by RefSeq, Jul 2008)

GeneCards Summary for RPS27L Gene: 
RPS27L (ribosomal protein S27-like) is a protein-coding gene. Among its related super-pathways are Viral mRNA Translation. GO annotations related to this gene include structural constituent of ribosome and translation activator activity. An important paralog of this gene is RPS27.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.2  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPS27L gene promoter:
         GR   NF-1   Pbx1a   Gfi-1   SREBP-1a   STAT3   FOXO1a   GR-alpha   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPS27L promoter sequence
   Search SABiosciences Chromatin IP Primers for RPS27L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS27L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22.2   Ensembl cytogenetic band:  15q22.2   HGNC cytogenetic band: 15q21.3

RPS27L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS27L gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M063445:  view genomic region     (about GC identifiers)

Start:
63,418,071 bp from pter      End:
63,450,220 bp from pter
Size:
32,150 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RS27L_HUMAN, Q71UM5 (See protein sequence)
Recommended Name: 40S ribosomal protein S27-like  
Size: 84 amino acids; 9477 Da
Cofactor: Binds 1 zinc ion per subunit (Potential)
Secondary accessions: Q9BTJ1

Explore the universe of human proteins at neXtProt for RPS27L: NX_Q71UM5

Explore proteomics data for RPS27L at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q71UM5

  • RPS27L Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RPS27L Protein Expression
    REFSEQ proteins: NP_057004.1  
    ENSEMBL proteins: 
     ENSP00000331019   ENSP00000453764   ENSP00000412026   ENSP00000405300   ENSP00000402423  

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    Cloud-Clone Corp. Proteins for RPS27L 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA18056458
    GO:0005840ribosome IEA--
    GO:0022627cytosolic small ribosomal subunit ----

    RPS27L for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RPS: S ribosomal proteins

    3 InterPro protein domains:
     IPR000592 Ribosomal_S27e
     IPR011332 Ribosomal_zn-bd_dom
     IPR023407 Ribosomal_S27e_Zn-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q71UM5

    ProtoNet protein and cluster: Q71UM5

    1 Blocks protein domain: IPB000592 Ribosomal protein S27E

    UniProtKB/Swiss-Prot: RS27L_HUMAN, Q71UM5
    Similarity: Belongs to the ribosomal protein S27e family


    RPS27L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome IEA--
    GO:0005515protein binding IPI--
    GO:0008494translation activator activity IDA18056458
    GO:0008656cysteine-type endopeptidase activator activity involved in apoptotic process IDA17057733
    GO:0046872metal ion binding IEA--
         
    RPS27L for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RPS27L:
     Increased cell number in S and 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidRPS27L 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RPS27L About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Viral mRNA Translation
    Ribosome0.59
    2Direct p53 effectors
    Direct p53 effectors

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for RPS27L
        Direct p53 effectors


    1         Kegg Pathway  (Kegg details for RPS27L):
        Ribosome


    RPS27L for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPS27L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/122 Interacting proteins for RPS27L (Q71UM51, 2, 3 ENSP000003310194) via UniProtKB, MINT, STRING, and/or I2D (see all 122)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDM2Q009871, 3, ENSP000004172814EBI-355126,EBI-389668 I2D: score=1 STRING: ENSP00000417281
    IKBKGQ9Y6K92, 3MINT-48139 I2D: score=2 
    MAP3K1Q132332, 3MINT-48279 I2D: score=2 
    MAP3K3Q997592, 3MINT-48387 I2D: score=2 
    TNFRSF1BP203332, 3MINT-49376 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair IMP18056458
    GO:0006412translation IDA18056458
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process IDA17057733
    GO:0006974response to DNA damage stimulus IDA18056458
    GO:0031571mitotic G1 DNA damage checkpoint IMP18056458

    RPS27L for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RPS27L (RS27L)

    Search CenterWatch for drugs/clinical trials and news about RPS27L / RS27L

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RPS27L gene: 
    NM_015920.3  

    Unigene Cluster for RPS27L:

    Ribosomal protein S27-like
    Hs.108957  [show with all ESTs]
    Unigene Representative Sequence: BF983391
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000559763 ENST00000330964(uc002alx.3 uc002aly.3) ENST00000462430
    ENST00000455271 ENST00000482846 ENST00000411926 ENST00000439025
    miRNA
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    hsa-miR-548am hsa-miR-875-5p hsa-miR-548e hsa-miR-548o hsa-miR-888* hsa-miR-3144-3p hsa-miR-33a* hsa-miR-3161
    SwitchGear 3'UTR luciferase reporter plasmidRPS27L 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF070668.1 AK024591.1 BC003667.1 

    18 DOTS entries:

    DT.97798991  DT.87017240  DT.100828358  DT.86995016  DT.95356544  DT.95154820  DT.40112737  DT.100828360 
    DT.95127151  DT.100828365  DT.100828366  DT.120667225  DT.100828362  DT.100828363  DT.101966880  DT.91759589 
    DT.95127150  DT.120667107 

    24/431 AceView cDNA sequences (see all 431):

    BU686514 N95533 BE440118 AV653919 AA844067 AA854218 W37801 CB857082 
    BX107465 BM874229 CB857745 BE858110 AA844088 AW013916 AI028417 BU735040 
    BM696404 AA071339 BM873353 AI192144 AI017241 AI088093 AA910498 AI335087 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPS27L expression in normal human tissues (normalized intensities)      RPS27L embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCAGACAGT
    RPS27L Expression
    About this image


    RPS27L expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/18 selected tissues (see all 18) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
             spinal cord/lateral wall/ventricular layer   
     
     Tooth (Integumentary System)    fully expand to see all 4 entries
             visceral organ/oral region/upper jaw   
     
     Nose (Sensory Organs)    fully expand to see all 3 entries
             sensory organ/nose/nasal cavity   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             visceral organ/lung/right lung   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb/leg   

    See RPS27L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPS27L

    SOURCE GeneReport for Unigene cluster: Hs.108957
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPS27L gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rps27l1 , 5 ribosomal protein S27-like1, 5 88.89(n)1
    100(a)1
      9 (36.23 cM)5
    679411  NM_026467.31  NP_080743.11 
     669460865 
    chicken
    (Gallus gallus)
    Aves RPS27L1 ribosomal protein S27-like 79.76(n)
    96.43(a)
      415372  XM_413758.3  XP_413758.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.77872 Transcribed sequence with moderate similarity to protein more 78.93(n)    AL919866.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG104233 structural constituent of ribosome 81(a)   96C8   --
    worm
    (Caenorhabditis elegans)
    Secernentea rps-276
    40S ribosomal protein S27
    76(a)
    1 → many
    V(103385-104070)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPS27B6
    RPS27A6
    Protein component of the small (40S) ribosomal sub...
    Protein component of the small (40S) ribosomal sub...
    71(a)
    70(a)
    many ↔ many
    many ↔ many
    VIII(147871-148669)
    XI(158613-159212)
    soybean
    (Glycine max)
    eudicotyledons Gma.66122 Transcribed sequence with strong similarity to protein more 73.91(n)  
    barley
    (Hordeum vulgare)
    Liliopsida Hv.80492 Transcribed sequence with moderate similarity to protein more 75.29(n)    BQ762936.1 


    ENSEMBL Gene Tree for RPS27L (if available)
    TreeFam Gene Tree for RPS27L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPS27L gene
    RPS272  
    2 SIMAP similar genes for RPS27L using alignment to 4 protein entries:     RS27L_HUMAN (see all proteins):
    RPS27    LOC392748

    RPS27L for paralogs           About GeneDecksing


    5/10 Pseudogenes.org Pseudogenes for RPS27L (see all 10)
    PGOHUM00000238647 PGOHUM00000239706 PGOHUM00000239906 PGOHUM00000239943 PGOHUM00000248924


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/192 SNPs in RPS27L are shown (see all 192)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs9539781,2
    C,F,A,H--63445144(+) TGCCAC/TAAGGT 1 -- ds500118Minor allele frequency- T:0.26NS EA NA WA 2458
    rs1167789571,2
    C,F--63445170(+) AGCAGA/GGTAGA 1 -- ds50011Minor allele frequency- G:0.12WA 118
    rs1146043491,2
    C,F--63445293(+) CCAGAA/GCCACT 1 -- ds50011Minor allele frequency- G:0.12WA 118
    rs1923834551,2
    --63445344(+) CAGAGA/GATTCA 1 -- ds50010--------
    rs1482230651,2
    F--63445403(+) CTTCAG/AATTTC 1 -- ds50011Minor allele frequency- A:0.01NS 142
    rs1460116931,2
    C--63445434(+) AAAAGC/GAGCTT 1 -- ds50010--------
    rs25888631,2
    C,F,A--63445458(-) GCTGGA/G/TGTGTG 1 -- ds50012WA NS 246
    rs1827653231,2
    --63445563(+) TCTTTC/TTAATT 1 -- ut310--------
    rs1858993361,2
    --63445592(+) TACACA/GTGCAG 1 -- ut310--------
    rs1399237811,2
    C--63445600(+) CAGGAC/TGTGCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RPS27L (63418071 - 63450220 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RPS27L:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv904305CNV Loss21882294
    nsv428305CNV Gain18775914
    nsv904304CNV Gain21882294
    esv27033CNV Gain+Loss19812545

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RPS27L for disorders           About MalaCards
    OMIM gene information: 612055    OMIM disorders: --


    RPS27L for disorders           About GeneDecksing


    Export disorders for RPS27L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RPS27L gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with RPS27L)
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    1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Ribosomal protein S27-like, a p53-inducible modulator of cell fate in response to genotoxic stress. (PubMed id 18056458)1, 9 Li J....Yu Q. (2007)
    4. Ribosomal protein S27L is a direct p53 target that regulates apoptosis. (PubMed id 17057733)1, 9 He H. and Sun Y. (2007)
    5. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Shotgun proteomics and network analysis of ubiquitin-r elated proteins from human breast carcinoma epithelial cells. (PubMed id 21853274)1 Zhou J....Liang S. (2012)
    8. Viral immune modulators perturb the human molecular ne twork by common and unique strategies. (PubMed id 22810585)1 Pichlmair A....Superti-Furga G. (2012)
    9. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    10. Proteomic dissection of the von Hippel-Lindau (VHL) i nteractome. (PubMed id 21942715)1 Lai Y....Shiio Y. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51065 HGNC: 18476 AceView: RPS27L Ensembl:ENSG00000185088 euGenes: HUgn51065
    ECgene: RPS27L Kegg: 51065 H-InvDB: RPS27L

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPS27L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RPS27L gene:
    Search GeneIP for patents involving RPS27L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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