RPS27L Gene
protein-coding GIFtS : 53
GCID: GC15 M063445
ribosomal protein S27-like
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Aliasesfor RPS27L gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Ribosomal Protein S27-Like 1 2 40S Ribosomal Protein S27-Like2
Export aliases for RPS27L gene to outside databases Previous GC identifers: GC15M059232 GC15M056493 GC15M060996 GC15M061161 GC15M061233 GC15M040268
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Summariesfor RPS27L gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for RPS27L : This gene encodes a protein sharing 96% amino acid similarity with ribosomal protein S27, which suggests the encoded protein may be a component of the 40S ribosomal subunit. (provided by RefSeq, Jul 2008)
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Genomic Viewsfor RPS27L gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000015.9 NC_018926.1 NT_010194.17 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the RPS27L gene promoter: GR NF-1 Pbx1a Gfi-1 SREBP-1a STAT3 FOXO1a GR-alpha FOXO1 Other transcription factors Search SABiosciences Chromatin IP Primers for RPS27L Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat RPS27L
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 15q22.2 Ensembl cytogenetic band: 15q22.2 HGNC cytogenetic band: 15q21.3 RPS27L Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 15 GeneLoc Exon Structure
GeneLoc location for GC15M063445: view genomic region
(about GC identifiers )
Start:
63,418,071 bp from pter
End:
63,450,220 bp from pter
Size:
32,150 bases
Orientation:
minus strand
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Proteinsfor RPS27L gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: RS27L_HUMAN, Q71UM5 (See
protein sequence )Recommended Name: 40S ribosomal protein S27-like Size : 84 amino acids; 9477 Da
Cofactor : Binds 1 zinc ion per subunit (Potential)
Secondary accessions : Q9BTJ1Explore the universe of human proteins at neXtProt for RPS27L: NX_Q71UM5 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q71UM5 RPS27L Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_057004.1 ENSEMBL proteins: ENSP00000331019 ENSP00000453764 ENSP00000412026 ENSP00000405300 ENSP00000402423 Human Recombinant Protein Products: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
RPS27L for ontologies About GeneDecksing RPS27L Antibody Products: Assay Products for RPS27L:
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Protein
Domains / Familiesfor RPS27L gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
RPS27L for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q71UM5 ProtoNet protein and cluster: Q71UM5
1 Blocks protein family : IPB000592 Ribosomal protein S27E UniProtKB/Swiss-Prot: RS27L_HUMAN, Q71UM5 Similarity : Belongs to the ribosomal protein S27e family
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Functionfor RPS27L gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RPS27L (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RPS27LOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: RPS27L (NM_015920 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPS27L Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RPS27L
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS27L
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view) : About this table
RPS27L for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for RPS27L :
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Pathways & Interactionsfor RPS27L gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Direct p53 effectors 2 Synthesis of PB1-F2
Pathway sources See GeneCards unified pathways Show all pathways 1 BioSystems Pathway for RPS27L 1
Kegg Pathway (Kegg details for RPS27L) :
RPS27L for pathways About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPS27L STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/122 Interacting proteins for RPS27L (Q71UM5 1 , 2 , 3 ENSP00000331019 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 122 )About this table Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8 ): About this table
RPS27L for ontologies About GeneDecksing
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Drugs & Compoundsfor RPS27L gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for RPS27L Search CenterWatch for drugs/clinical trials and news about RPS27L / RS27L
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Transcriptsfor RPS27L gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
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siRNAs from
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shRNA from
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Tagged/untagged cDNA clones from
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Vector BioLabs ,
Primers from
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SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for RPS27L gene: NM_015920.3 Unigene Cluster for RPS27L:
Ribosomal protein S27-like Hs.108957 [show with all ESTs ] Unigene Representative Sequence: BF983391 7 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000559763 ENST00000330964 (uc002alx.3 uc002aly.3 ) ENST00000462430 ENST00000455271 ENST00000482846 ENST00000411926 ENST00000439025 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RPS27L (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RPS27LOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: RPS27L (NM_015920 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPS27L Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RPS27L
Additional cDNA sequence: AF070668.1 AK024591.1 BC003667.1
18 DOTS entries : DT.97798991 DT.87017240
DT.100828358 DT.86995016 DT.95356544 DT.95154820 DT.40112737 DT.100828360 DT.95127151 DT.100828365 DT.100828366 DT.120667225 DT.100828362 DT.100828363 DT.101966880 DT.91759589 DT.95127150 DT.120667107 24/431 AceView cDNA sequences (see all 431 ):
AI571404 BM873836 AL701787 AW013916 BM873543 BM669146 CB955743 AA974851 CB857381 BM873779 BM874229 AA666202 AI146608 N29263 BE858110 AA156054 BC031307 AI088093 AA137068 BC047648 BM874799 BM873353 AI017241 AI817421 GeneLoc Exon Structure
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Expression for RPS27L gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section RPS27L expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CTCAGACAGT
About this image RPS27L expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See RPS27L Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for RPS27L SOURCE GeneReport for Unigene cluster: Hs.108957 SABiosciences Custom PCR Arrays for RPS27L Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for RPS27LBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat RPS27L QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat RPS27L QIAGEN QuantiFast Probe-based Assays in human , mouse , rat RPS27L In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS27L
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Orthologsfor RPS27L gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for RPS27L gene from 7/26 species (see all 26 ) About this table
ENSEMBL Gene Tree for RPS27L (if available)TreeFam Gene Tree for RPS27L (if available)
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Paralogsfor RPS27L gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for RPS27L gene RPS27 2 2 SIMAP similar genes for RPS27L using alignment to 4 protein entries: RS27L_HUMAN (see all proteins ):RPS27 LOC392748
RPS27L for paralogs About GeneDecksing 5/10 Pseudogenes.org Pseudogenes for RPS27L (see all 10 )PGOHUM00000238647 PGOHUM00000239706 PGOHUM00000239906 PGOHUM00000239943 PGOHUM00000248924
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Genomic Variantsfor RPS27L gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 15 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for RPS27L (63418071 - 63450220 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for RPS27L 1 CNV : 66819
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing RPS27L
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Disorders
/ Diseasesfor RPS27L gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
RPS27L for disorders About GeneDecksing
OMIM gene information: 612055
OMIM disorders : --1 disease for RPS27L : About MalaCards malaria Export disorders for RPS27L gene to outside databases
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Publicationsfor RPS27L gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for RPS27L gene, integrated from 9 sources (see all 15 ): (articles sorted by number of sources associating them with RPS27L) Utopia : connect your pdf to the dynamic world of online information
Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152) 1 , 2 , 3 Zhang Q.-H.... Chen Z. (2000) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Ribosomal protein S27-like, a p53-inducible modulator of cell fate in response to genotoxic stress. (PubMed id 18056458) 1 , 9 Li J....Yu Q. (2007) Ribosomal protein S27L is a direct p53 target that regulates apoptosis. (PubMed id 17057733) 1 , 9 He H. and Sun Y. (2007) A census of human soluble protein complexes. (PubMed id 22939629) 1 Havugimana P.C....Emili A. (2012) Shotgun proteomics and network analysis of ubiquitin-r elated proteins from human breast carcinoma epithelial cells. (PubMed id 21853274) 1 Zhou J....Liang S. (2012) A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883) 1 Kristensen A.R....Foster L.J. (2012) Proteomic dissection of the von Hippel-Lindau (VHL) i nteractome. (PubMed id 21942715) 1 Lai Y....Shiio Y. (2011) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) Initial characterization of the human central proteome. (PubMed id 21269460) 2 Burkard T.R.... Colinge J. (2011)
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External Searches for RPS27L gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing RPS27L gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing RPS27L gene
(According to HUGE )
About This Section --
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Specialized Databases showing RPS27L gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for RPS27L Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for RPS27L gene: Search GeneIP for patents involving RPS27L GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor RPS27L gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for RPS27L OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for RPS27L OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for RPS27L OriGene Protein Over-expression Lysate for RPS27L Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for RPS27L OriGene 3'-UTR Clone for RPS27L OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RPS27L OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RPS27L Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for RPS27L OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for RPS27L OriGene Custom Protein Services for RPS27L OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RPS27L QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing RPS27L QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat RPS27L QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat RPS27L QIAGEN QuantiFast Probe-based Assays in human , mouse , rat RPS27L QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat RPS27L
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RPS27L Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS27L
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RPS27L
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