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Aliases for RPS27L Gene

Aliases for RPS27L Gene

  • Ribosomal Protein S27-Like 2 3

External Ids for RPS27L Gene

Previous GeneCards Identifiers for RPS27L Gene

  • GC15M059232
  • GC15M056493
  • GC15M060996
  • GC15M061161
  • GC15M061233
  • GC15M063445
  • GC15M040268

Summaries for RPS27L Gene

Entrez Gene Summary for RPS27L Gene

  • This gene encodes a protein sharing 96% amino acid similarity with ribosomal protein S27, which suggests the encoded protein may be a component of the 40S ribosomal subunit. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS27L Gene

RPS27L (Ribosomal Protein S27-Like) is a Protein Coding gene. Among its related pathways are Direct p53 effectors and CFTR translational fidelity (class I mutations). GO annotations related to this gene include structural constituent of ribosome and translation activator activity. An important paralog of this gene is RPS27.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS27L Gene

Genomics for RPS27L Gene

Regulatory Elements for RPS27L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RPS27L Gene

63,125,872 bp from pter
63,158,021 bp from pter
32,150 bases
Minus strand

Genomic View for RPS27L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPS27L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS27L Gene

Proteins for RPS27L Gene

  • Protein details for RPS27L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    40S ribosomal protein S27-like
    Protein Accession:
    Secondary Accessions:
    • Q9BTJ1

    Protein attributes for RPS27L Gene

    84 amino acids
    Molecular mass:
    9477 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available

neXtProt entry for RPS27L Gene

Proteomics data for RPS27L Gene at MOPED

Post-translational modifications for RPS27L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPS27L Gene

Antibody Products

No data available for DME Specific Peptides for RPS27L Gene

Domains for RPS27L Gene

Gene Families for RPS27L Gene

Protein Domains for RPS27L Gene

Suggested Antigen Peptide Sequences for RPS27L Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein S27e family.
  • Belongs to the ribosomal protein S27e family.
genes like me logo Genes that share domains with RPS27L: view

Function for RPS27L Gene

Gene Ontology (GO) - Molecular Function for RPS27L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA --
GO:0005515 protein binding IPI 21170087
GO:0008494 translation activator activity IDA 18056458
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process IDA 17057733
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with RPS27L: view

Phenotypes for RPS27L Gene

GenomeRNAi human phenotypes for RPS27L:
genes like me logo Genes that share phenotypes with RPS27L: view

miRNA for RPS27L Gene

miRTarBase miRNAs that target RPS27L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS27L Gene

Localization for RPS27L Gene

Subcellular locations from

Jensen Localization Image for RPS27L Gene COMPARTMENTS Subcellular localization image for RPS27L gene
Compartment Confidence
nucleus 5
extracellular 3
cytosol 1

Gene Ontology (GO) - Cellular Components for RPS27L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA 18056458
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with RPS27L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS27L Gene

Pathways for RPS27L Gene

genes like me logo Genes that share pathways with RPS27L: view

Pathways by source for RPS27L Gene

1 BioSystems pathway for RPS27L Gene
1 KEGG pathway for RPS27L Gene

Gene Ontology (GO) - Biological Process for RPS27L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IMP 18056458
GO:0006412 translation IDA 18056458
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA 17057733
GO:0006974 cellular response to DNA damage stimulus IDA 18056458
GO:0031571 mitotic G1 DNA damage checkpoint IMP 18056458
genes like me logo Genes that share ontologies with RPS27L: view

Transcripts for RPS27L Gene

mRNA/cDNA for RPS27L Gene

Unigene Clusters for RPS27L Gene

Ribosomal protein S27-like:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPS27L

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS27L Gene

No ASD Table

Relevant External Links for RPS27L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS27L Gene

mRNA expression in normal human tissues for RPS27L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for RPS27L Gene

This gene is overexpressed in Islet of Langerhans (7.8) and Amniocyte (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS27L Gene

SOURCE GeneReport for Unigene cluster for RPS27L Gene Hs.108957

genes like me logo Genes that share expressions with RPS27L: view

Expression partners for RPS27L Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS27L Gene

Orthologs for RPS27L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS27L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPS27L 35
  • 92.86 (n)
  • 98.81 (a)
RPS27L 36
  • 99 (a)
RPS27L 36
  • 99 (a)
(Canis familiaris)
Mammalia RPS27L 35
  • 93.65 (n)
  • 100 (a)
RPS27L 36
  • 96 (a)
(Mus musculus)
Mammalia Rps27l 35
  • 88.89 (n)
  • 100 (a)
Rps27l 16
Rps27l 36
  • 100 (a)
(Pan troglodytes)
Mammalia RPS27L 35
  • 100 (n)
  • 100 (a)
RPS27L 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rps27l 35
  • 90.48 (n)
  • 100 (a)
(Monodelphis domestica)
Mammalia RPS27L 36
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia RPS27L 36
  • 90 (a)
(Gallus gallus)
Aves RPS27L 35
  • 79.76 (n)
  • 96.43 (a)
(Danio rerio)
Actinopterygii Dr.7787 35
zgc:136826 35
  • 79.37 (n)
  • 89.29 (a)
rps27.2 36
  • 89 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10423 37
  • 81 (a)
RpS27 36
  • 79 (a)
(Caenorhabditis elegans)
Secernentea rps-27 36
  • 76 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS27A 36
  • 68 (a)
RPS27B 36
  • 70 (a)
(Glycine max)
eudicotyledons Gma.6612 35
(Hordeum vulgare)
Liliopsida Hv.8049 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10862 36
  • 94 (a)
Species with no ortholog for RPS27L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RPS27L Gene

Gene Tree for RPS27L (if available)
Gene Tree for RPS27L (if available)

Paralogs for RPS27L Gene

Paralogs for RPS27L Gene

(2) SIMAP similar genes for RPS27L Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RPS27L: view

Variants for RPS27L Gene

Sequence variations from dbSNP and Humsavar for RPS27L Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs14775 -- 63,153,929(+) ACCAA(A/T)TGTAA utr-variant-3-prime
rs953978 -- 63,152,945(+) TGCCA(C/T)AAGGT downstream-variant-500B
rs1053695 -- 63,153,990(-) GTCTC(A/G)CAGAA utr-variant-3-prime
rs2270948 -- 63,156,581(+) TTAAC(C/G)ATACG intron-variant
rs577728777 -- 63,156,625(+) ATCCT(C/G)GGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPS27L Gene

Variant ID Type Subtype PubMed ID
nsv428305 CNV Gain 18775914
nsv904304 CNV Gain 21882294
esv27033 CNV Gain+Loss 19812545
nsv904305 CNV Loss 21882294

Relevant External Links for RPS27L Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS27L Gene

Disorders for RPS27L Gene

No disorders were found for RPS27L Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for RPS27L Gene

Publications for RPS27L Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4
  2. Ribosomal protein S27L is a direct p53 target that regulates apoptosis. (PMID: 17057733) He H. … Sun Y. (Oncogene 2007) 3 23
  3. Ribosomal protein S27-like, a p53-inducible modulator of cell fate in response to genotoxic stress. (PMID: 18056458) Li J. … Yu Q. (Cancer Res. 2007) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for RPS27L Gene

Sources for RPS27L Gene

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