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Aliases for RPS27L Gene

Aliases for RPS27L Gene

  • Ribosomal Protein S27 Like 2 3 5
  • Small Ribosomal Subunit Protein ES27-Like 4
  • Ribosomal Protein S27-Like 2

External Ids for RPS27L Gene

Previous GeneCards Identifiers for RPS27L Gene

  • GC15M059232
  • GC15M056493
  • GC15M060996
  • GC15M061161
  • GC15M061233
  • GC15M063445
  • GC15M040268
  • GC15M063128
  • GC15M063134
  • GC15M063368
  • GC15M063414

Summaries for RPS27L Gene

Entrez Gene Summary for RPS27L Gene

  • This gene encodes a protein sharing 96% amino acid similarity with ribosomal protein S27, which suggests the encoded protein may be a component of the 40S ribosomal subunit. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS27L Gene

RPS27L (Ribosomal Protein S27 Like) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. GO annotations related to this gene include poly(A) RNA binding and cysteine-type endopeptidase activator activity involved in apoptotic process. An important paralog of this gene is RPS27.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS27L Gene

Genomics for RPS27L Gene

Regulatory Elements for RPS27L Gene

Enhancers for RPS27L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G063188 1.8 FANTOM5 ENCODE dbSUPER 26.7 -34.9 -34882 8.5 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A YBX1 ZBTB7B YY1 ZNF143 RPS27L RAB8B LACTB APH1B USP3
GH15G063155 1.4 ENCODE dbSUPER 33.6 +0.9 918 3.3 HDGF FOXA2 MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B RPS27L LACTB ENSG00000259498
GH15G063231 1.8 FANTOM5 Ensembl ENCODE dbSUPER 25.5 -75.3 -75342 4.1 FOXA2 PKNOX1 ARNT CREB3L1 ZNF133 TCF12 GATA2 FOS CAVIN1 PPARG RPS27L RAB8B LACTB APH1B CA12 FBXL22 USP3 ENSG00000259498
GH15G063209 1.7 Ensembl ENCODE dbSUPER 25.3 -54.6 -54566 5.2 CREB3L1 MLX ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 RPS27L RAB8B APH1B LACTB FBXL22 CA12
GH15G063133 1.7 FANTOM5 Ensembl ENCODE dbSUPER 19.6 +22.6 22634 4.0 TBP ZNF146 CBX3 TAF1 ZNF133 JUN MAX CEBPG RFX5 FOSL1 LACTB RPS27L RAB8B APH1B CA12 TPM1 ENSG00000259498 USP3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPS27L on UCSC Golden Path with GeneCards custom track

Promoters for RPS27L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000077740 921 2601 HDGF FOXA2 MLX CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for RPS27L Gene

Chromosome:
15
Start:
63,125,872 bp from pter
End:
63,158,021 bp from pter
Size:
32,150 bases
Orientation:
Minus strand

Genomic View for RPS27L Gene

Genes around RPS27L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS27L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS27L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS27L Gene

Proteins for RPS27L Gene

  • Protein details for RPS27L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q71UM5-RS27L_HUMAN
    Recommended name:
    40S ribosomal protein S27-like
    Protein Accession:
    Q71UM5
    Secondary Accessions:
    • Q9BTJ1

    Protein attributes for RPS27L Gene

    Size:
    84 amino acids
    Molecular mass:
    9477 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

neXtProt entry for RPS27L Gene

Post-translational modifications for RPS27L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPS27L Gene

No data available for DME Specific Peptides for RPS27L Gene

Domains & Families for RPS27L Gene

Gene Families for RPS27L Gene

Protein Domains for RPS27L Gene

Suggested Antigen Peptide Sequences for RPS27L Gene

Graphical View of Domain Structure for InterPro Entry

Q71UM5

UniProtKB/Swiss-Prot:

RS27L_HUMAN :
  • Belongs to the eukaryotic ribosomal protein eS27 family.
Family:
  • Belongs to the eukaryotic ribosomal protein eS27 family.
genes like me logo Genes that share domains with RPS27L: view

Function for RPS27L Gene

Gene Ontology (GO) - Molecular Function for RPS27L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22681889
GO:0003735 structural constituent of ribosome IBA,IEA --
GO:0005515 protein binding IPI 21170087
GO:0008494 translation activator activity IDA 18056458
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process IDA 17057733
genes like me logo Genes that share ontologies with RPS27L: view
genes like me logo Genes that share phenotypes with RPS27L: view

Animal Model Products

miRNA for RPS27L Gene

miRTarBase miRNAs that target RPS27L

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS27L Gene

Localization for RPS27L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS27L gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 3

Gene Ontology (GO) - Cellular Components for RPS27L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA 18056458
GO:0005840 ribosome IEA --
GO:0022627 cytosolic small ribosomal subunit IBA --
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with RPS27L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS27L Gene

Pathways & Interactions for RPS27L Gene

SuperPathways for RPS27L Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
.56
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing in the nucleus and cytosol
5 HIV Life Cycle
.45
genes like me logo Genes that share pathways with RPS27L: view

Gene Ontology (GO) - Biological Process for RPS27L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000028 ribosomal small subunit assembly IBA --
GO:0006281 DNA repair IMP 18056458
GO:0006412 translation IDA,IEA 18056458
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA --
GO:0006974 cellular response to DNA damage stimulus IDA 18056458
genes like me logo Genes that share ontologies with RPS27L: view

No data available for SIGNOR curated interactions for RPS27L Gene

Drugs & Compounds for RPS27L Gene

No Compound Related Data Available

Transcripts for RPS27L Gene

Unigene Clusters for RPS27L Gene

Ribosomal protein S27-like:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS27L Gene

No ASD Table

Relevant External Links for RPS27L Gene

GeneLoc Exon Structure for
RPS27L
ECgene alternative splicing isoforms for
RPS27L

Expression for RPS27L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPS27L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPS27L Gene

This gene is overexpressed in Islet of Langerhans (7.8) and Amniocyte (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPS27L Gene



Protein tissue co-expression partners for RPS27L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS27L Gene:

RPS27L

SOURCE GeneReport for Unigene cluster for RPS27L Gene:

Hs.108957

Evidence on tissue expression from TISSUES for RPS27L Gene

  • Liver(4.5)
  • Skin(2.6)
  • Nervous system(2.4)
  • Lung(2.1)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with RPS27L: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS27L Gene

Orthologs for RPS27L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS27L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPS27L 34 35
  • 100 (n)
oppossum
(Monodelphis domestica)
Mammalia RPS27L 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPS27L 34 35
  • 93.65 (n)
cow
(Bos Taurus)
Mammalia RPS27L 34 35 35
  • 92.86 (n)
rat
(Rattus norvegicus)
Mammalia Rps27l 34
  • 90.48 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RPS27L 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rps27l 34 16 35
  • 88.89 (n)
chicken
(Gallus gallus)
Aves RPS27L 34
  • 79.76 (n)
zebrafish
(Danio rerio)
Actinopterygii rps27.2 35
  • 89 (a)
OneToOne
zgc:136826 34
  • 79.37 (n)
Dr.7787 34
fruit fly
(Drosophila melanogaster)
Insecta CG10423 36
  • 81 (a)
RpS27 35
  • 79 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rps-27 35
  • 76 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS27B 35
  • 70 (a)
ManyToMany
RPS27A 35
  • 68 (a)
ManyToMany
soybean
(Glycine max)
eudicotyledons Gma.6612 34
barley
(Hordeum vulgare)
Liliopsida Hv.8049 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10862 35
  • 94 (a)
OneToMany
Species where no ortholog for RPS27L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RPS27L Gene

ENSEMBL:
Gene Tree for RPS27L (if available)
TreeFam:
Gene Tree for RPS27L (if available)

Paralogs for RPS27L Gene

Paralogs for RPS27L Gene

(2) SIMAP similar genes for RPS27L Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RPS27L: view

Variants for RPS27L Gene

Sequence variations from dbSNP and Humsavar for RPS27L Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000263127 -- 63,153,702(+) CTTGA(C/G)TGACA utr-variant-3-prime
rs1000303088 -- 63,159,325(+) ACCAC(A/G)CCTGG upstream-variant-2KB
rs1000576820 -- 63,157,659(+) GGGCT(G/T)GTTGG upstream-variant-2KB
rs1000629049 -- 63,157,842(+) GGTGG(A/G)CACAC upstream-variant-2KB
rs1000635827 -- 63,158,129(+) AGGGG(G/T)CCTGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPS27L Gene

Variant ID Type Subtype PubMed ID
esv27033 CNV gain+loss 19812545
esv3636712 CNV gain 21293372
nsv1035441 CNV gain 25217958
nsv428305 CNV gain 18775914

Variation tolerance for RPS27L Gene

Residual Variation Intolerance Score: 49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS27L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPS27L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS27L Gene

Disorders for RPS27L Gene

Relevant External Links for RPS27L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPS27L

No disorders were found for RPS27L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPS27L Gene

Publications for RPS27L Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 64
  2. Ribosomal protein S27L is a direct p53 target that regulates apoptosis. (PMID: 17057733) He H. … Sun Y. (Oncogene 2007) 3 22 64
  3. Ribosomal protein S27-like, a p53-inducible modulator of cell fate in response to genotoxic stress. (PMID: 18056458) Li J. … Yu Q. (Cancer Res. 2007) 3 22 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Repression of rRNA transcription by PARIS contributes to Parkinson's disease. (PMID: 25315684) Kang H. … Shin J.H. (Neurobiol. Dis. 2015) 3 64

Products for RPS27L Gene

Sources for RPS27L Gene

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