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RPS27AP11 Gene

pseudogene   GIFtS: 16
GCID: GC06P113903

Ribosomal Protein S27a Pseudogene 11

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribosomal Protein S27a Pseudogene 111 2
RPS27A_4_7402

External Ids:    HGNC: 361261   Entrez Gene: 7285902   Ensembl: ENSG000002182087   

Export aliases for RPS27AP11 gene to outside databases

Previous GC identifer: GC06P114012


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RPS27AP11 Gene:
RPS27AP11 (ribosomal protein S27a pseudogene 11) is a pseudogene. Diseases associated with RPS27AP11 include multiple myeloma, and myeloma.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for RPS27AP11
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPS27AP11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q22.1

RPS27AP11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS27AP11 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P113903:  view genomic region     (about GC identifiers)

Start:
113,902,665 bp from pter      End:
113,903,201 bp from pter
Size:
537 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB: --


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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  --

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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  --

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for RPS27AP11 About   (see all 44)  
See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1CDK-mediated phosphorylation and removal of Cdc6
CDK-mediated phosphorylation and removal of Cdc60.94
p53-Independent G1/S DNA damage checkpoint0.91
Regulation of activated PAK-2p34 by proteasome mediated degradation0.94
Assembly of the pre-replicative complex0.89
Ubiquitin-dependent degradation of Cyclin D10.94
Destabilization of mRNA by AUF1 (hnRNP D0)0.88
Ubiquitin-dependent degradation of Cyclin D0.94
G1/S DNA Damage Checkpoints0.87
2Influenza Viral RNA Transcription and Replication
Viral mRNA Translation0.94
Eukaryotic Translation Initiation0.89
Peptide chain elongation0.94
Cap-dependent Translation Initiation0.89
Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
Formation of a pool of free 40S subunits0.94
Nonsense-Mediated Decay0.89
3Loss of Function of SMAD2/3 in Cancer
Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer0.72
TGFBR2 MSI Frameshift Mutants in Cancer0.60
SMAD2/SMAD3-SMAD4 heterotrimer regulates transcription0.72
Signaling by TGF-beta Receptor Complex in Cancer0.60
Loss of Function of SMAD2/3 in Cancer0.60
Signaling by TGF-beta Receptor Complex0.60
TGFBR1 LBD Mutants in Cancer0.60
TGFBR1 KD Mutants in Cancer0.60
4Signaling by NOTCH1 PEST Domain Mutants in Cancer
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants0.79
Signaling by NOTCH1 HD Domain Mutants in Cancer0.79
Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
Constitutive Signaling by NOTCH1 PEST Domain Mutants0.79
FBXW7 Mutants and NOTCH1 in Cancer0.79
Signaling by NOTCH1 t(7;9)(NOTCH1-M1580 K2555) Translocation Mutant0.79
Signaling by NOTCH1 in Cancer0.79
NOTCH1 Intracellular Domain Regulates Transcription0.68
5Signaling by FGFR
Signaling by FGFR0.91
Signaling by EGFR in Cancer0.82
Signaling by FGFR in disease0.91
Signalling by NGF0.71
Signaling by ERBB20.89
Signaling by constitutively active EGFR0.00
Signaling by EGFR0.83
Downregulation of ERBB2-ERBB3 signaling0.00



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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000402798
miRNA
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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RPS27AP11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
RPS27AP11 Expression
About this image


RPS27AP11 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 15) fully expand
 
 Brain (Nervous System)    fully expand to see all 4 entries
         Cerebral Cortex
 
 Ovary (Reproductive System)    fully expand to see all 2 entries
         Ovarian Mesenchymal Stroma Cells Ovary Interstitium
         Oviduct
 
 Bone (Muscoskeletal System)
         Bone Marrow
 
 Trophoblast (Extraembryonic Tissues)
         Trophoblast Cells Trophoblast
 
 Testis (Reproductive System)
         Leydig Cells Testis Interstitium
RPS27AP11 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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  --

ENSEMBL Gene Tree for RPS27AP11 (if available)
TreeFam Gene Tree for RPS27AP11 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing RPS27AP11
DNA2.0 Custom Variant and Variant Library Synthesis for RPS27AP11

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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3 diseases for RPS27AP11:    
About MalaCards
multiple myeloma    myeloma    endotheliitis


RPS27AP11 for disorders           About GeneDecksing

Genetic Association Database (GAD): RPS27AP11

Export disorders for RPS27AP11 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for RPS27AP11 gene integrated from 10 sources:
(articles sorted by number of sources associating them with RPS27AP11)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Comparative analysis of processed ribosomal protein pseudogenes in four mammalian genomes. (PubMed id 19123937)1, 3 Balasubramanian S....Gerstein M. (Genome Biol. 2009)
  2. Identification of ubiquitinated proteins from human multiple myeloma U266 cells by proteomics. (PubMed id 22108332)1 Jia H....He Q. (Biomed. Environ. Sci. 2011)
  3. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)4 Vasan R.S....Benjamin E.J. (BMC Med. Genet. 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 728590 HGNC: 36126 Ensembl:ENSG00000218208 euGenes: HUgn728590 ECgene: RPS27AP11
H-InvDB: RPS27AP11

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for RPS27AP11 gene:
Search GeneIP for patents involving RPS27AP11

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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