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Aliases for RPS27A Gene

Aliases for RPS27A Gene

  • Ribosomal Protein S27a 2 3
  • Ubiquitin Carboxyl Extension Protein 80 2 3 4
  • UBCEP1 3 4
  • UBA80 3 4
  • Ubiquitin And Ribosomal Protein S27a 3
  • Ubiquitin-40S Ribosomal Protein S27a 3
  • Epididymis Luminal Protein 112 3
  • 40S Ribosomal Protein S27a 3
  • Ubiquitin-CEP80 3
  • Ubiquitin C 3
  • UBCEP80 3
  • HEL112 3
  • CEP80 3
  • S27A 3
  • UBC 3

External Ids for RPS27A Gene

Previous GeneCards Identifiers for RPS27A Gene

  • GC02P055497
  • GC02P055646
  • GC02P055417
  • GC02P055434
  • GC02P055371
  • GC02P055313
  • GC02P055459
  • GC02P055193

Summaries for RPS27A Gene

Entrez Gene Summary for RPS27A Gene

  • Ubiquitin, a highly conserved protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome, is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein S27a at the C terminus. When expressed in yeast, the protein is post-translationally processed, generating free ubiquitin monomer and ribosomal protein S27a. Ribosomal protein S27a is a component of the 40S subunit of the ribosome and belongs to the S27AE family of ribosomal proteins. It contains C4-type zinc finger domains and is located in the cytoplasm. Pseudogenes derived from this gene are present in the genome. As with ribosomal protein S27a, ribosomal protein L40 is also synthesized as a fusion protein with ubiquitin; similarly, ribosomal protein S30 is synthesized as a fusion protein with the ubiquitin-like protein fubi. Multiple alternatively spliced transcript variants that encode the same proteins have been identified.[provided by RefSeq, Sep 2008]

GeneCards Summary for RPS27A Gene

RPS27A (Ribosomal Protein S27a) is a Protein Coding gene. Diseases associated with RPS27A include neuronal intranuclear inclusion disease and dementia pugilistica. Among its related pathways are PI-3K cascade and Signaling by FGFR. GO annotations related to this gene include structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPS27A Gene

  • Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling

  • 40S Ribosomal protein S27a: Component of the 40S subunit of the ribosome

Gene Wiki entry for RPS27A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS27A Gene

Genomics for RPS27A Gene

Regulatory Elements for RPS27A Gene

Genomic Location for RPS27A Gene

Start:
55,231,903 bp from pter
End:
55,235,853 bp from pter
Size:
3,951 bases
Orientation:
Plus strand

Genomic View for RPS27A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPS27A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS27A Gene

Proteins for RPS27A Gene

  • Protein details for RPS27A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62979-RS27A_HUMAN
    Recommended name:
    Ubiquitin-40S ribosomal protein S27a
    Protein Accession:
    P62979
    Secondary Accessions:
    • P02248
    • P02249
    • P02250
    • P14798
    • P62988
    • Q29120
    • Q6LBL4
    • Q6LDU5
    • Q8WYN8
    • Q91887
    • Q91888
    • Q9BQ77
    • Q9BWD6
    • Q9BX98
    • Q9UEF2
    • Q9UEG1
    • Q9UEK8
    • Q9UPK7

    Protein attributes for RPS27A Gene

    Size:
    156 amino acids
    Molecular mass:
    17965 Da
    Quaternary structure:
    • Ribosomal protein S27a is part of the 40S ribosomal subunit.
    Miscellaneous:
    • For a better understanding, features related to ubiquitin are only indicated for the first chain
    • Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains

    Three dimensional structures from OCA and Proteopedia for RPS27A Gene

neXtProt entry for RPS27A Gene

Proteomics data for RPS27A Gene at MOPED

Post-translational modifications for RPS27A Gene

  • Ubiquitin: Phosphorylated at Ser-65 by PINK1 during mitophagy. Phosphorylated ubiquitin specifically binds and activates parkin (PARK2), triggering mitophagy (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291). Phosphorylation does not affect E1-mediated E2 charging of ubiquitin but affects discharging of E2 enzymes to form polyubiquitin chains. It also affects deubiquitination by deubiquitinase enzymes such as USP30 (PubMed:25527291).
  • Ubiquitination at Lys6, Lys11, Lys27, Lys29, Lys33, Lys48, Lys63, Lys113, Lys143, and Lys152
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS27A Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RPS27A (RPS27A)

No data available for DME Specific Peptides for RPS27A Gene

Domains for RPS27A Gene

Gene Families for RPS27A Gene

HGNC:
  • RPS :S ribosomal proteins

Graphical View of Domain Structure for InterPro Entry

P62979

UniProtKB/Swiss-Prot:

RS27A_HUMAN :
  • P62979
Domain:
  • Contains 1 ubiquitin-like domain.
Family:
  • In the N-terminal section; belongs to the ubiquitin family.
  • In the C-terminal section; belongs to the ribosomal protein S27Ae family.
genes like me logo Genes that share domains with RPS27A: view

Function for RPS27A Gene

Molecular function for RPS27A Gene

GENATLAS Biochemistry: 60S ribosomal protein S27A
UniProtKB/Swiss-Prot Function: Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling
UniProtKB/Swiss-Prot Function: 40S Ribosomal protein S27a: Component of the 40S subunit of the ribosome

Gene Ontology (GO) - Molecular Function for RPS27A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IDA 15883184
GO:0005515 protein binding IPI 16189514
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RPS27A: view
genes like me logo Genes that share phenotypes with RPS27A: view

Animal Model Products

CRISPR Products

miRNA for RPS27A Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPS27A Gene

Localization for RPS27A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS27A Gene

Ubiquitin: Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS27A Gene COMPARTMENTS Subcellular localization image for RPS27A gene
Compartment Confidence
cytosol 5
endosome 4
nucleus 4
cytoskeleton 2
extracellular 2

Gene Ontology (GO) - Cellular Components for RPS27A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA 16791210
GO:0005737 cytoplasm IDA 16791210
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RPS27A: view

Pathways for RPS27A Gene

SuperPathways for RPS27A Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.38
2 Loss of Function of SMAD2/3 in Cancer
3 Influenza Viral RNA Transcription and Replication
4 Signaling by NOTCH1 PEST Domain Mutants in Cancer
5 Signaling by FGFR
genes like me logo Genes that share pathways with RPS27A: view

Gene Ontology (GO) - Biological Process for RPS27A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS --
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000187 activation of MAPK activity TAS --
genes like me logo Genes that share ontologies with RPS27A: view

Compounds for RPS27A Gene

(115) Novoseek inferred chemical compound relationships for RPS27A Gene

Compound -log(P) Hits PubMed IDs
lactacystin 83 12
mg 132 82.8 20
lysine 74 114
propanil 62.5 6
epoxomicin 61.4 4
genes like me logo Genes that share compounds with RPS27A: view

Transcripts for RPS27A Gene

Unigene Clusters for RPS27A Gene

Ribosomal protein S27a:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPS27A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS27A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5
SP1:
SP2:

Relevant External Links for RPS27A Gene

GeneLoc Exon Structure for
RPS27A
ECgene alternative splicing isoforms for
RPS27A

Expression for RPS27A Gene

mRNA expression in normal human tissues for RPS27A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS27A Gene

SOURCE GeneReport for Unigene cluster for RPS27A Gene Hs.311640

genes like me logo Genes that share expressions with RPS27A: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS27A Gene

Orthologs for RPS27A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS27A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC101059860 35
  • 99.79 (n)
  • 100 (a)
RPS27A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RPS27A 35
  • 92.95 (n)
  • 100 (a)
RPS27A 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 97 (a)
OneToMany
RPS27A 35
  • 94.44 (n)
  • 100 (a)
RPS27A 36
  • 100 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rps27a 35
  • 92.52 (n)
  • 99.36 (a)
Rps27a 16
Rps27a 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 96 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia RPS27A 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rps27a 35
  • 91.03 (n)
  • 99.36 (a)
chicken
(Gallus gallus)
Aves RPS27A 35
  • 87.18 (n)
  • 99.36 (a)
RPS27A 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPS27A 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rps27a 35
  • 85.47 (n)
  • 100 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8914 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
rps27a 35
  • 84.19 (n)
  • 98.72 (a)
rps27a 36
  • 99 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RpS27A 35
  • 77.78 (n)
  • 91.03 (a)
RpS27A 36
  • 91 (a)
OneToOne
Ubi-p63E 37
  • 100 (a)
worm
(Caenorhabditis elegans)
Secernentea F34H10.1 36
  • 28 (a)
OneToMany
K08C9.7 36
  • 26 (a)
OneToMany
ubl-1 36
  • 54 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL128W 35
  • 70.27 (n)
  • 81.76 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS31 35
  • 71.3 (n)
  • 82.78 (a)
RPS31 36
  • 82 (a)
OneToOne
RPS31 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D18304g 35
  • 70.67 (n)
  • 81.33 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7312 35
thale cress
(Arabidopsis thaliana)
eudicotyledons UBQ6 35
  • 74.56 (n)
  • 85.53 (a)
rice
(Oryza sativa)
Liliopsida Os01g0328400 35
  • 72.15 (n)
  • 85.53 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04553 35
  • 70.39 (n)
  • 86.18 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ubi3 35
  • 78.16 (n)
  • 84.83 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 79 (a)
OneToOne
Species with no ortholog for RPS27A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS27A Gene

ENSEMBL:
Gene Tree for RPS27A (if available)
TreeFam:
Gene Tree for RPS27A (if available)

Paralogs for RPS27A Gene

Selected SIMAP similar genes for RPS27A Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RPS27A: view

No data available for Paralogs for RPS27A Gene

Variants for RPS27A Gene

Sequence variations from dbSNP and Humsavar for RPS27A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs2230613 -- 55,234,855(+) TGTTG(A/C)GACTT reference, synonymous-codon
rs2576722 -- 55,234,687(-) GTATC(A/T)GATTC intron-variant
rs11557873 -- 55,235,533(+) GTGGC(A/T)AATGT reference, stop-gained
rs13028202 -- 55,235,431(+) AGGTG(A/G)ATGAG missense, reference
rs13028392 -- 55,235,434(+) TGGAT(A/G)AGAAT missense, reference

Structural Variations from Database of Genomic Variants (DGV) for RPS27A Gene

Variant ID Type Subtype PubMed ID
esv2720078 CNV Deletion 23290073
nsv522016 CNV Gain 19592680

Relevant External Links for RPS27A Gene

HapMap Linkage Disequilibrium report
RPS27A
Human Gene Mutation Database (HGMD)
RPS27A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS27A Gene

Disorders for RPS27A Gene

(1) University of Copenhagen DISEASES for RPS27A Gene

(95) Novoseek inferred disease relationships for RPS27A Gene

Disease -log(P) Hits PubMed IDs
frontotemporal dementia 81.6 61
neurofibrillary tangles 79.9 49
paired helical filament 78.2 39
neurodegenerative diseases 77.5 81
picks disease 75.8 9
genes like me logo Genes that share disorders with RPS27A: view

No data available for UniProtKB/Swiss-Prot for RPS27A Gene

Publications for RPS27A Gene

  1. Effect of ubiquitin on platelet functions: possible identity with platelet activity suppressive lymphokine (PASL). (PMID: 1657614) Pancre V. … Auriault C. (Eur. J. Immunol. 1991) 3 4 23
  2. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3 4
  3. Differential expression of translation-associated genes in benign and malignant human breast tumours. (PMID: 1370760) Adams S.M. … Varley J.M. (Br. J. Cancer 1992) 3 4
  4. Nucleotide sequence analysis of a cDNA encoding human ubiquitin reveals that ubiquitin is synthesized as a precursor. (PMID: 2581967) Lund P.K. … van Wyk J.J. (J. Biol. Chem. 1985) 3 4
  5. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PMID: 8706699) Vladimirov S.N. … Otto A. (Eur. J. Biochem. 1996) 3 4

Products for RPS27A Gene

Sources for RPS27A Gene

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