Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RPS27A Gene

protein-coding GIFtS: 64
GCID: GC02P055459

ribosomal protein S27a

Explore 177 diseases affiliated with
RPS27A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ribosomal Protein S27a¹ ²		40S Ribosomal Protein S27a²
S27A¹ ²		CEP80²
UBCEP80¹ ²		UBC²
Ubiquitin Carboxyl Extension Protein 80² ³		Ubiquitin And Ribosomal Protein S27a²
UBA80² ³		Ubiquitin C²
UBCEP1² ³		Ubiquitin-40S Ribosomal Protein S27a²
Uba80¹		Ubiquitin-CEP80¹

External Ids:	HGNC: 10417¹	Entrez Gene: 6233²	Ensembl: ENSG00000143947⁷	OMIM: 191343⁵	UniProtKB: P62979³

Export aliases for RPS27A gene to outside databases

Previous GC identifers: GC02P055497 GC02P055646 GC02P055417 GC02P055434 GC02P055371 GC02P055313 GC02P055193

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RPS27A:

Ubiquitin, a highly conserved protein that has a major role in targeting cellular proteins for degradation by the 26S

proteosome, is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin

fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and

ribosomal protein S27a at the C terminus. When expressed in yeast, the protein is post-translationally processed,

generating free ubiquitin monomer and ribosomal protein S27a. Ribosomal protein S27a is a component of the 40S subunit

of the ribosome and belongs to the S27AE family of ribosomal proteins. It contains C4-type zinc finger domains and is

located in the cytoplasm. Pseudogenes derived from this gene are present in the genome. As with ribosomal protein

S27a, ribosomal protein L40 is also synthesized as a fusion protein with ubiquitin; similarly, ribosomal protein S30

is synthesized as a fusion protein with the ubiquitin-like protein fubi. Multiple alternatively spliced transcript

variants that encode the same proteins have been identified.(provided by RefSeq, Sep 2008)

UniProtKB/Swiss-Prot: RS27A_HUMAN, P62979

Function: Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound,

it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via

different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the

ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different

functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair;

Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation;

Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is

involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as

well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains

formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of

target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is

free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in

signaling

Function: Ribosomal protein S27a is a component of the 40S subunit of the ribosome

Gene Wiki entry for RPS27A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022184.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RPS27A gene promoter:
c-Fos AP-1 c-Jun IRF-1 Hlf
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RPS27A promoter sequence

Search SABiosciences Chromatin IP Primers for RPS27A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS27A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p16 Ensembl cytogenetic band: 2p16.1 HGNC cytogenetic band: 2p16

RPS27A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS27A gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P055459: view genomic region (about GC identifiers)

Start:	55,459,039 bp from pter	End:	55,462,989 bp from pter
Size:	3,951 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RS27A_HUMAN, P62979 (See protein sequence)

Recommended Name: Ubiquitin-40S ribosomal protein S27a precursor

Size: 156 amino acids; 17965 Da

Subunit: Ribosomal protein S27a is part of the 40S ribosomal subunit (By similarity)

Subcellular location: Ubiquitin: Cytoplasm (By similarity). Nucleus (By similarity)

Miscellaneous: Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin

fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with

exact head to tail repeats, the number of repeats differ between species and strains

Miscellaneous: For a better understanding, features related to ubiquitin are only indicated for the first chain

6/18 PDB 3D structures from and Proteopedia for RPS27A (see all 18):

2KHW (3D)

2KOX (3D)

2KTF (3D)

2KWU (3D)

2KWV (3D)

2L0F (3D)

Secondary accessions: P02248 P02249 P02250 P14798 P62988 Q29120 Q6LBL4 Q6LDU5 Q8WYN8 Q91887 Q91888

Q9BQ77 Q9BWD6 Q9BX98 Q9UEF2 Q9UEG1 Q9UEK8 Q9UPK7

Explore the universe of human proteins at neXtProt for RPS27A: NX_P62979

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P62979

RPS27A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001129064.1 NP_001170884.1 NP_002945.1

ENSEMBL proteins:

ENSP00000383981 ENSP00000272317 ENSP00000408482 ENSP00000385659

Reactome Protein details: P62979
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 3): RPS27A OriGene Custom Protein Services for RPS27A
	GenScript Custom Purified and Recombinant Proteins Services for RPS27A
	Novus Biologicals RPS27A Proteins Novus Biologicals RPS27A Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for RPS27A
	Uscn Proteins for RPS27A

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005654	nucleoplasm	TAS	--
GO:0005829	cytosol	TAS	--
GO:0005886	plasma membrane	TAS	--
GO:0010008	endosome membrane	TAS	--
GO:0015935	small ribosomal subunit	IDA	15883184

RPS27A for ontologies About GeneDecksing

RPS27A Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies (see all 2): RPS27A OriGene Custom Antibody Services for RPS27A
	GenScript Custom Superior Antibodies Services for RPS27A
	Novus Biologicals RPS27A Antibodies
	Search for Antibodies for RPS27A at Abcam
	Uscn Antibodies for RPS27A
	ThermoFisher Antibody for RPS27A

Assay Products for RPS27A:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RPS27A
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for RPS27A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RPS27A for domains About GeneDecksing

5 InterPro domains/families:

IPR002906 Ribosomal_S27a

IPR019956 Ubiquitin_subgr

IPR019954 Ubiquitin_CS

IPR000626 Ubiquitin

IPR019955 Ubiquitin_supergroup

Graphical View of Domain Structure for InterPro Entry P62979

ProtoNet protein and cluster: P62979

1 Blocks protein family: IPB002906 Ribosomal protein S27a

UniProtKB/Swiss-Prot: RS27A_HUMAN, P62979

Similarity: In the N-terminal section; belongs to the ubiquitin family

Similarity: In the C-terminal section; belongs to the ribosomal protein S27Ae family

Similarity: Contains 1 ubiquitin-like domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary: