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Aliases for RPS27A Gene

Aliases for RPS27A Gene

  • Ribosomal Protein S27a 2 3 5
  • Ubiquitin Carboxyl Extension Protein 80 2 3 4
  • UBCEP1 3 4
  • UBA80 3 4
  • Ubiquitin And Ribosomal Protein S27a 3
  • Ubiquitin-40S Ribosomal Protein S27a 3
  • Epididymis Luminal Protein 112 3
  • 40S Ribosomal Protein S27a 3
  • Ubiquitin-CEP80 3
  • Ubiquitin C 3
  • UBCEP80 3
  • HEL112 3
  • CEP80 3
  • S27A 3
  • UBC 3

External Ids for RPS27A Gene

Previous GeneCards Identifiers for RPS27A Gene

  • GC02P055497
  • GC02P055646
  • GC02P055417
  • GC02P055434
  • GC02P055371
  • GC02P055313
  • GC02P055459
  • GC02P055193

Summaries for RPS27A Gene

Entrez Gene Summary for RPS27A Gene

  • Ubiquitin, a highly conserved protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome, is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein S27a at the C terminus. When expressed in yeast, the protein is post-translationally processed, generating free ubiquitin monomer and ribosomal protein S27a. Ribosomal protein S27a is a component of the 40S subunit of the ribosome and belongs to the S27AE family of ribosomal proteins. It contains C4-type zinc finger domains and is located in the cytoplasm. Pseudogenes derived from this gene are present in the genome. As with ribosomal protein S27a, ribosomal protein L40 is also synthesized as a fusion protein with ubiquitin; similarly, ribosomal protein S30 is synthesized as a fusion protein with the ubiquitin-like protein fubi. Multiple alternatively spliced transcript variants that encode the same proteins have been identified.[provided by RefSeq, Sep 2008]

GeneCards Summary for RPS27A Gene

RPS27A (Ribosomal Protein S27a) is a Protein Coding gene. Diseases associated with RPS27A include Oculopharyngeal Muscular Dystrophy and Corticobasal Degeneration. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Ovarian tumor domain proteases. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome. An important paralog of this gene is ZFAND4.

UniProtKB/Swiss-Prot for RPS27A Gene

  • Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.

  • 40S Ribosomal protein S27a: Component of the 40S subunit of the ribosome.

Gene Wiki entry for RPS27A Gene

Additional gene information for RPS27A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS27A Gene

Genomics for RPS27A Gene

Regulatory Elements for RPS27A Gene

Enhancers for RPS27A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H055115 1.5 Ensembl ENCODE dbSUPER 20.3 -115.9 -115866 0.9 ATF1 TCF12 GTF3C2 ZNF766 GATA2 ELK1 FOS ATF7 CAVIN1 NCOA1 RPS27A ENSG00000203327 PRORSD1P CLHC1 RTN4 GC02P055128
GH02H055231 1.4 ENCODE dbSUPER 21.6 +1.1 1083 3.7 PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 ZNF207 ZNF143 CLHC1 RPS27A PRORSD1P RTN4 GC02P055233
GH02H055268 1.2 ENCODE 24.5 +37.3 37315 2 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC PPARGC1A RPS27A CLHC1 MTIF2 GC02P055233
GH02H054523 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12.1 -707.3 -707273 2.6 HDGF CTCF FOXA2 JUN EBF1 BATF FOSL1 GATA3 EED ATF7 EML6 ENSG00000203327 PRORSD1P RPS27A SPTBN1 CLHC1 ACYP2 RNU7-172P RPL23AP32 GC02P054516
GH02H054554 1.9 FANTOM5 ENCODE dbSUPER 9.9 -672.7 -672699 8.8 HDGF PKNOX1 FOXA2 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SPTBN1 EML6 ENSG00000203327 RPS27A RTN4 LOC105374640 PIR49112 GC02M054620
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPS27A on UCSC Golden Path with GeneCards custom track

Promoters for RPS27A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000117336 597 2201 PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 ZNF207 ZNF143

Genomic Locations for RPS27A Gene

Genomic Locations for RPS27A Gene
chr2:55,231,903-55,235,853
(GRCh38/hg38)
Size:
3,951 bases
Orientation:
Plus strand
chr2:55,459,039-55,462,989
(GRCh37/hg19)

Genomic View for RPS27A Gene

Genes around RPS27A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS27A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS27A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS27A Gene

Proteins for RPS27A Gene

  • Protein details for RPS27A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62979-RS27A_HUMAN
    Recommended name:
    Ubiquitin-40S ribosomal protein S27a
    Protein Accession:
    P62979
    Secondary Accessions:
    • P02248
    • P02249
    • P02250
    • P14798
    • P62988
    • Q29120
    • Q6LBL4
    • Q6LDU5
    • Q8WYN8
    • Q91887
    • Q91888
    • Q9BQ77
    • Q9BWD6
    • Q9BX98
    • Q9UEF2
    • Q9UEG1
    • Q9UEK8
    • Q9UPK7

    Protein attributes for RPS27A Gene

    Size:
    156 amino acids
    Molecular mass:
    17965 Da
    Quaternary structure:
    • Ribosomal protein S27a is part of the 40S ribosomal subunit.
    Miscellaneous:
    • For a better understanding, features related to ubiquitin are only indicated for the first chain.
    • Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.

    Three dimensional structures from OCA and Proteopedia for RPS27A Gene

neXtProt entry for RPS27A Gene

Post-translational modifications for RPS27A Gene

  • Ubiquitin: Phosphorylated at Ser-65 by PINK1 during mitophagy. Phosphorylated ubiquitin specifically binds and activates parkin (PRKN), triggering mitophagy (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291). Phosphorylation does not affect E1-mediated E2 charging of ubiquitin but affects discharging of E2 enzymes to form polyubiquitin chains. It also affects deubiquitination by deubiquitinase enzymes such as USP30 (PubMed:25527291).
  • Ubiquitination at isoforms=6, Lys11, Lys27, isoforms=29, isoforms=33, isoforms=48, Lys63, Lys113, and Lys143
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS27A Gene

No data available for DME Specific Peptides for RPS27A Gene

Domains & Families for RPS27A Gene

Gene Families for RPS27A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Graphical View of Domain Structure for InterPro Entry

P62979

UniProtKB/Swiss-Prot:

RS27A_HUMAN :
  • In the N-terminal section; belongs to the ubiquitin family.
Family:
  • In the N-terminal section; belongs to the ubiquitin family.
  • In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
genes like me logo Genes that share domains with RPS27A: view

Function for RPS27A Gene

Molecular function for RPS27A Gene

GENATLAS Biochemistry:
60S ribosomal protein S27A
UniProtKB/Swiss-Prot Function:
Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.
UniProtKB/Swiss-Prot Function:
40S Ribosomal protein S27a: Component of the 40S subunit of the ribosome.

Phenotypes From GWAS Catalog for RPS27A Gene

Gene Ontology (GO) - Molecular Function for RPS27A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0003735 structural constituent of ribosome IDA 15883184
GO:0005515 protein binding IPI 15936278
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RPS27A: view
genes like me logo Genes that share phenotypes with RPS27A: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS27A Gene

Localization for RPS27A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS27A Gene

Ubiquitin: Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS27A gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 4
mitochondrion 4
endoplasmic reticulum 4
endosome 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Endoplasmic reticulum (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPS27A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16502470
GO:0005634 nucleus IDA,IEA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA 16791210
GO:0005737 cytoplasm IEA,IDA 16791210
genes like me logo Genes that share ontologies with RPS27A: view

Pathways & Interactions for RPS27A Gene

SuperPathways for RPS27A Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 Activated TLR4 signalling
4 Viral mRNA Translation
.55
5 HIV Life Cycle
.45
genes like me logo Genes that share pathways with RPS27A: view

Gene Ontology (GO) - Biological Process for RPS27A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS --
GO:0000165 MAPK cascade TAS --
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000187 activation of MAPK activity TAS --
genes like me logo Genes that share ontologies with RPS27A: view

No data available for SIGNOR curated interactions for RPS27A Gene

Drugs & Compounds for RPS27A Gene

(54) Drugs for RPS27A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(61) Additional Compounds for RPS27A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RPS27A: view

Transcripts for RPS27A Gene

Unigene Clusters for RPS27A Gene

Ribosomal protein S27a:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS27A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5
SP1:
SP2:

Relevant External Links for RPS27A Gene

GeneLoc Exon Structure for
RPS27A
ECgene alternative splicing isoforms for
RPS27A

Expression for RPS27A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPS27A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPS27A Gene

This gene is overexpressed in Brain (20.0) and Skin (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPS27A Gene



Protein tissue co-expression partners for RPS27A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS27A Gene:

RPS27A

SOURCE GeneReport for Unigene cluster for RPS27A Gene:

Hs.311640

Evidence on tissue expression from TISSUES for RPS27A Gene

  • Skin(4.7)
  • Nervous system(4.7)
  • Pancreas(4.4)
  • Liver(4.3)
  • Lung(3.9)
  • Intestine(3.6)
  • Eye(3.5)
  • Blood(3.3)
  • Kidney(3.1)
  • Muscle(3.1)
  • Stomach(3)
  • Heart(2.8)
  • Bone marrow(2.5)
  • Bone(2.4)
  • Spleen(2.4)
  • Lymph node(2.3)
  • Thyroid gland(2.3)
  • Adrenal gland(2.2)
genes like me logo Genes that share expression patterns with RPS27A: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS27A Gene

Orthologs for RPS27A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS27A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC101059860 33
  • 99.79 (n)
RPS27A 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 97 (a)
OneToMany
RPS27A 33 34
  • 94.44 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 96 (a)
OneToMany
-- 34
  • 85 (a)
OneToMany
cow
(Bos Taurus)
Mammalia RPS27A 33 34
  • 92.95 (n)