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RPS27A Gene

protein-coding   GIFtS: 66
GCID: GC02P055459

Ribosomal Protein S27a

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribosomal Protein S27a1 2     UBC2
Ubiquitin Carboxyl Extension Protein 801 2 3     UBCEP802
UBA802 3     Epididymis Luminal Protein 1122
UBCEP12 3     Ubiquitin And Ribosomal Protein S27a2
40S Ribosomal Protein S27a2     Ubiquitin C2
CEP802     Ubiquitin-40S Ribosomal Protein S27a2
HEL1122     ubiquitin-CEP802
S27A2     

External Ids:    HGNC: 104171   Entrez Gene: 62332   Ensembl: ENSG000001439477   OMIM: 1913435   UniProtKB: P629793   

Export aliases for RPS27A gene to outside databases

Previous GC identifers: GC02P055497 GC02P055646 GC02P055417 GC02P055434 GC02P055371 GC02P055313 GC02P055193


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RPS27A Gene:
Ubiquitin, a highly conserved protein that has a major role in targeting cellular proteins for degradation by the
26S proteosome, is synthesized as a precursor protein consisting of either polyubiquitin chains or a single
ubiquitin fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N
terminus and ribosomal protein S27a at the C terminus. When expressed in yeast, the protein is
post-translationally processed, generating free ubiquitin monomer and ribosomal protein S27a. Ribosomal protein
S27a is a component of the 40S subunit of the ribosome and belongs to the S27AE family of ribosomal proteins. It
contains C4-type zinc finger domains and is located in the cytoplasm. Pseudogenes derived from this gene are
present in the genome. As with ribosomal protein S27a, ribosomal protein L40 is also synthesized as a fusion
protein with ubiquitin; similarly, ribosomal protein S30 is synthesized as a fusion protein with the
ubiquitin-like protein fubi. Multiple alternatively spliced transcript variants that encode the same proteins
have been identified.(provided by RefSeq, Sep 2008)

GeneCards Summary for RPS27A Gene:
RPS27A (ribosomal protein S27a) is a protein-coding gene. Diseases associated with RPS27A include dementia pugilistica, and neuronal intranuclear inclusion disease. GO annotations related to this gene include structural constituent of ribosome.

UniProtKB/Swiss-Prot: RS27A_HUMAN, P62979
Function: Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently
bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer
linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the
initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target
protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may
be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and
in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase
modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in
endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription
factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling.
Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or
Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct
roles, such as in activation of protein kinases, and in signaling
Function: Ribosomal protein S27a is a component of the 40S subunit of the ribosome

Gene Wiki entry for RPS27A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPS27A gene promoter:
         c-Fos   AP-1   c-Jun   IRF-1   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPS27A promoter sequence
   Search Chromatin IP Primers for RPS27A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPS27A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p16   Ensembl cytogenetic band:  2p16.1   HGNC cytogenetic band: 2p16

RPS27A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS27A gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P055459:  view genomic region     (about GC identifiers)

Start:
55,459,039 bp from pter      End:
55,462,989 bp from pter
Size:
3,951 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RS27A_HUMAN, P62979 (See protein sequence)
Recommended Name: Ubiquitin-40S ribosomal protein S27a precursor  
Size: 156 amino acids; 17965 Da
Subunit: Ribosomal protein S27a is part of the 40S ribosomal subunit (By similarity)
Miscellaneous: Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of
ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin
precursor with exact head to tail repeats, the number of repeats differ between species and strains
Miscellaneous: For a better understanding, features related to ubiquitin are only indicated for the first chain
Selected PDB 3D structures from and Proteopedia for RPS27A (see all 19):
2KHW (3D)        2KOX (3D)        2KTF (3D)        2KWU (3D)        2KWV (3D)        2L0F (3D)    
Secondary accessions: P02248 P02249 P02250 P14798 P62988 Q29120 Q6LBL4 Q6LDU5 Q8WYN8 Q91887
Q91888 Q9BQ77 Q9BWD6 Q9BX98 Q9UEF2 Q9UEG1 Q9UEK8 Q9UPK7

Explore the universe of human proteins at neXtProt for RPS27A: NX_P62979

Explore proteomics data for RPS27A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys6, Lys11, Lys27, Lys29, Lys33, Lys48, Lys63, Lys113, Lys143, Lys152
  • Modification sites at PhosphoSitePlus

  • See RPS27A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001129064.1  NP_001170884.1  NP_002945.1  

    ENSEMBL proteins: 
     ENSP00000383981   ENSP00000272317   ENSP00000408482   ENSP00000385659  
    Reactome Protein details: P62979

    RPS27A Human Recombinant Protein Products:

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    Novus Biologicals RPS27A Proteins
    Novus Biologicals RPS27A Lysates
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RPS: S ribosomal proteins

    5 InterPro protein domains:
     IPR002906 Ribosomal_S27a
     IPR019956 Ubiquitin
     IPR011332 Ribosomal_zn-bd
     IPR019954 Ubiquitin_CS
     IPR000626 Ubiquitin_dom

    Graphical View of Domain Structure for InterPro Entry P62979

    ProtoNet protein and cluster: P62979

    1 Blocks protein domain: IPB002906 Ribosomal protein S27a

    UniProtKB/Swiss-Prot: RS27A_HUMAN, P62979
    Similarity: In the N-terminal section; belongs to the ubiquitin family
    Similarity: In the C-terminal section; belongs to the ribosomal protein S27Ae family
    Similarity: Contains 1 ubiquitin-like domain


    RPS27A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RS27A_HUMAN, P62979
    Function: Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently
    bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer
    linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the
    initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target
    protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may
    be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and
    in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase
    modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in
    endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription
    factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling.
    Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or
    Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct
    roles, such as in activation of protein kinases, and in signaling
    Function: Ribosomal protein S27a is a component of the 40S subunit of the ribosome

         Genatlas biochemistry entry for RPS27A:
    60S ribosomal protein S27A

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome IDA15883184
    GO:0005515protein binding ----
    GO:0044822poly(A) RNA binding IDA--
    GO:0046872metal ion binding IEA--
         
    RPS27A for ontologies           About GeneDecksing


    Phenotypes:
         9 GenomeRNAi human phenotypes for RPS27A:
     Cytoplasmic 40S maturation def  Decreased Hepatitis C virus re  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 
     Decreased viability  Decreased viability of wild-ty  Increased S DNA content, incre  Nucleolar pre-40S maturation d 
     S arrest 

    Animal Models:
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    hsa-mir-23b-3p (MIRT046242), hsa-mir-30b-5p (MIRT046153), hsa-mir-30c-5p (MIRT047980), hsa-mir-17-5p (MIRT050798), hsa-mir-26a-5p (MIRT050094)

    Block miRNA regulation of human, mouse, rat RPS27A using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate RPS27A:
    hsa-miR-511
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RS27A_HUMAN, P62979: Ubiquitin: Cytoplasm (By similarity). Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    endosome4
    nucleus4
    cytoskeleton2
    extracellular2

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--
    GO:0005840ribosome ----
    GO:0005886plasma membrane TAS--

    RPS27A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RPS27A About   (see all 45)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CFTR translational fidelity class I mutations
    CFTR translational fidelity class I mutations 0.60
    Ribosome0.54
    Cytoplasmic Ribosomal Proteins0.60
    2CDK-mediated phosphorylation and removal of Cdc6
    CDK-mediated phosphorylation and removal of Cdc60.94
    p53-Independent G1/S DNA damage checkpoint0.91
    Regulation of activated PAK-2p34 by proteasome mediated degradation0.94
    Assembly of the pre-replicative complex0.89
    Ubiquitin-dependent degradation of Cyclin D10.94
    Destabilization of mRNA by AUF1 (hnRNP D0)0.88
    Ubiquitin-dependent degradation of Cyclin D0.94
    G1/S DNA Damage Checkpoints0.87
    3Influenza Viral RNA Transcription and Replication
    Viral mRNA Translation0.94
    Eukaryotic Translation Initiation0.89
    Peptide chain elongation0.94
    Cap-dependent Translation Initiation0.89
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    Formation of a pool of free 40S subunits0.94
    Nonsense-Mediated Decay0.89
    4Loss of Function of SMAD2/3 in Cancer
    Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer0.72
    TGFBR2 MSI Frameshift Mutants in Cancer0.60
    SMAD2/SMAD3-SMAD4 heterotrimer regulates transcription0.72
    Signaling by TGF-beta Receptor Complex in Cancer0.60
    Loss of Function of SMAD2/3 in Cancer0.60
    Signaling by TGF-beta Receptor Complex0.60
    TGFBR1 LBD Mutants in Cancer0.60
    TGFBR1 KD Mutants in Cancer0.60
    5Signaling by NOTCH1 PEST Domain Mutants in Cancer
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants0.79
    Signaling by NOTCH1 HD Domain Mutants in Cancer0.79
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Constitutive Signaling by NOTCH1 PEST Domain Mutants0.79
    FBXW7 Mutants and NOTCH1 in Cancer0.79
    Signaling by NOTCH1 t(7;9)(NOTCH1-M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH1 in Cancer0.79
    NOTCH1 Intracellular Domain Regulates Transcription0.68

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RPS27A (see all 17)
        Remodeling of Adherens Junctions
    TRAF Pathway
    BRCA1 Pathway
    CDK5 Pathway
    Inhibition of Ribosome Biogenesis by p14(ARF)

    1 GeneGo (Thomson Reuters) Pathway for RPS27A
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPS27A
        Cytoplasmic Ribosomal Proteins

    Selected Reactome Pathways for RPS27A (see all 95)
        NOTCH1 Intracellular Domain Regulates Transcription
    FCERI mediated NF-kB activation
    Regulation of innate immune responses to cytosolic DNA
    Orc1 removal from chromatin
    TAK1 activates NFkB by phosphorylation and activation of IKKs complex


    1 Kegg Pathway  (Kegg details for RPS27A):
        Ribosome


    RPS27A for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RPS27A
    Interactions:

        Search GeneGlobe Interaction Network for RPS27A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPS27A (P629792, 3 ENSP000002723174) via UniProtKB, MINT, STRING, and/or I2D (see all 563)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 91):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS--
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0000187activation of MAPK activity TAS--

    RPS27A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for RPS27A (RS27A)

    Selected Novoseek inferred chemical compound relationships for RPS27A gene (see all 115)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lactacystin 83 12 17976956 (1), 15466866 (1), 15781258 (1), 9528855 (1) (see all 12)
    mg 132 82.8 21 9814555 (3), 16275144 (2), 19636403 (1), 19218244 (1) (see all 17)
    lysine 74 175 18042044 (3), 12890688 (3), 17334503 (3), 15100473 (2) (see all 99)
    propanil 62.5 10 17078930 (2), 19111546 (1), 17052190 (1), 15314065 (1) (see all 5)
    epoxomicin 61.4 4 17220374 (1), 16687393 (1), 19103198 (1), 19274461 (1)
    spectrins 59.7 1 15929114 (1)
    bortezomib 57.8 12 12710947 (2), 15486193 (2), 18176107 (2), 12802699 (1) (see all 8)
    thioflavine s 57.1 7 9496540 (2), 9546999 (1), 19756365 (1), 8304839 (1) (see all 6)
    glutamine 55.3 39 18599482 (2), 12702496 (2), 19666572 (2), 14749733 (1) (see all 29)
    hnco(.-) 55.2 6 17828465 (1), 14611222 (1), 14872130 (1), 17031954 (1) (see all 6)



    RPS27A for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RPS27A gene (3 alternative transcripts): 
    NM_001135592.2  NM_001177413.1  NM_002954.5  

    Unigene Clusters for RPS27A:

    Ribosomal protein S27a
    Hs.311640  [show with all ESTs], Hs.546292  [show with all ESTs]
    Unigene Representative Sequences: BU588489, CD049144
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000402285 ENST00000272317(uc010yow.2 uc002ryk.3) ENST00000449323
    ENST00000404735(uc021vhs.1) ENST00000463185 ENST00000471772 ENST00000478196
    ENST00000494756 ENST00000495843 ENST00000468810
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK225718.1 AY952889.1 BC042362.1 M10939.1 S79522.1 X63237.1 

    Selected DOTS entries (see all 48):

    DT.95112295  DT.100697635  DT.91825993  DT.100697639  DT.85103673  DT.120997662  DT.97792960  DT.100697633 
    DT.120997616  DT.92407348  DT.95313101  DT.320761  DT.91873812  DT.100697642  DT.100032328  DT.101987384 
    DT.120997688  DT.91963052  DT.121383699  DT.121383657  DT.40261136  DT.100697632  DT.101987382  DT.120662624 

    Selected AceView cDNA sequences (see all 1254):

    AA328611 BG121793 AI338636 BQ653449 AI366916 BM551347 CB107684 BM692099 
    BF036410 CD676940 AI708254 BM843345 BE277464 BQ423822 AI719781 CB155393 
    BM873863 BG685064 BM817974 BM090610 CB125016 AI080574 BG026258 BU072411 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for RPS27A    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5
    SP1:                                    
    SP2:                                    


    ECgene alternative splicing isoforms for RPS27A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    RPS27A expression in normal human tissues (normalized intensities)      RPS27A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTAACAAA
    RPS27A Expression
    About this image


    RPS27A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Ovary (Reproductive System)
             Primary Oocyte Primary Follicle
     
     Gonad
             Primary Oocyte Primary Follicle
     
     Endoderm (Gastrulation Derivatives)
             Endoderm-like cells
     
     Umbilical Cord (Extraembryonic Tissues)
    RPS27A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPS27A Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.311640 Hs.546292
        Custom PCR Arrays for RPS27A
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS27A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPS27A gene from Selected species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rps27a1 , 5 ribosomal protein S27A1, 5 92.52(n)1
    99.36(a)1
      11 (16.79 cM)5
    782941  NM_001033865.11  NP_001029037.11 
     295458465 
    chicken
    (Gallus gallus)
    Aves RPS27A1 ribosomal protein S27a 87.18(n)
    99.36(a)
      395796  NM_204953.1  NP_990284.1 
    lizard
    (Anolis carolinensis)
    Reptilia RPS27A6
    ribosomal protein S27a
    99(a)
    1 ↔ 1
    1(255741229-255748489)
    African clawed frog
    (Xenopus laevis)
    Amphibia CB591870.12   -- 84.17(n)    CB591870.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC049478.12   -- 84.13(n)   393474  BC049478.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ubi-p63E3
    RpS27A1
    response to heat protein degradation
    tagging3
    Ribosomal protein S27A1
    100(a)3
    77.78(n)1
    91.03(a)1
      3 63F53
    344201  NM_057430.41  NP_476778.11 
    worm
    (Caenorhabditis elegans)
    Secernentea ubl-16
    F34H10.16
    (see all 3)
    Protein F34H10.1 (F34H10.1) mRNA, complete cds
    (see all 3)
    54(a)
    28(a)
    (see all 3)
    many → 1
    many → 1
    (see all 3)
    III(3068306-3069212) WBGene00006725
    X(9626135-9626849) WBGene00009378
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPS31(YLR167W)4
    RPS311
    Fusion protein that is cleaved to yield a ribosomal more4
    RPS311
    71.3(n)1
    82.78(a)1
      12(498947-499405)4
    8508641, 4  NP_013268.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons UBQ61 UBQ6 74.56(n)
    85.53(a)
      819323  NM_130278.3  NP_566095.1 
    rice
    (Oryza sativa)
    Liliopsida AK119731.12   -- 72.47(n)    AK119731.1 


    ENSEMBL Gene Tree for RPS27A (if available)
    TreeFam Gene Tree for RPS27A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RPS27A gene
    13 SIMAP similar genes for RPS27A using alignment to 6 protein entries:     RS27A_HUMAN (see all proteins):
    UBA52    UBB    UBC    DKFZp434K0435    UbC    UBBP4
    NEDD8    NEDD8-MDP1    ZFAND4    FAU    PARK2    RAD23A
    UBL4A

    RPS27A for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for RPS27A (see all 19)
    PGOHUM00000247751 PGOHUM00000247152 PGOHUM00000248907 PGOHUM00000237222 PGOHUM00000234476


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for RPS27A (see all 53)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs115578721,2
    C,Funtested155327599(+) CTTTGT/CCTGAC 6 /P /S mis13Minor allele frequency- C:0.00NS NA EU 6003
    rs1862672161,2
    C--55461802(+) TCCCTA/GTAAAC 3 -- int10--------
    rs1907357041,2
    C--55461811(+) ACTGTC/TAGTTA 3 -- int10--------
    rs25767221,2
    C,F,A,H--55461823(-) GTATCT/AGATTC 3 -- int118Minor allele frequency- A:0.21NS EA NA WA CSA 798
    rs786822191,2
    F--55461862(+) CCTCAA/GATGTT 3 -- int11Minor allele frequency- G:0.01WA 118
    rs1841805391,2
    --55461891(+) TTTTAA/CTTAGA 3 -- int10--------
    rs1181005761,2
    C,F--55461964(+) ATTAAC/AAGGAG 3 -- int11Minor allele frequency- A:0.05EA 120
    rs22306131,2
    C,F--55461991(+) TGTTGA/CGACTT 6 R syn13Minor allele frequency- C:0.02NS NA 4772
    rs1998720561,2
    --55462142(+) GCTTAC/TTTGGA 3 -- int10--------
    rs1886815311,2
    --55462267(+) TTTTCC/TTGTTT 3 -- int10--------

    HapMap Linkage Disequilibrium report for RPS27A (55459039 - 55462989 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RPS27A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2720078CNV Deletion23290073
    nsv522016CNV Gain19592680

    Human Gene Mutation Database (HGMD): RPS27A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RPS27A
    DNA2.0 Custom Variant and Variant Library Synthesis for RPS27A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 191343    OMIM disorders: --

    Selected diseases for RPS27A (see all 169):    About MalaCards
    dementia pugilistica    neuronal intranuclear inclusion disease    dementia - subcortical    giant axonal neuropathy
    neuroaxonal dystrophy, infantile    neuroaxonal dystrophy    myositis    endotoxin hyporesponsiveness
    oculopharyngeal muscular dystrophy    rem sleep behavior disorder    amyotrophic lateral sclerosis-parkinsonism/dementia complex    alexander disease
    myotilinopathy    amyotrophic lateral sclerosis with frontotemporal dementia    progressive supranuclear palsy    werdnig-hoffmann disease
    myopathy congenital    corticobasal degeneration    striatonigral degeneration    spinocerebellar degeneration

    1 disease from the University of Copenhagen DISEASES database for RPS27A:
    Parkinson's disease

    RPS27A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for RPS27A gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    frontotemporal dementia 81.6 65 19938689 (2), 17279000 (2), 7575218 (2), 17615169 (2) (see all 56)
    neurofibrillary tangles 79.9 51 1850450 (2), 1321968 (2), 1372157 (1), 1321966 (1) (see all 47)
    paired helical filament 78.2 40 9496540 (2), 8391280 (2), 1953965 (2), 9829817 (2) (see all 35)
    neurodegenerative diseases 77.5 87 16447778 (3), 11980917 (2), 20061621 (2), 14522239 (2) (see all 75)
    picks disease 75.8 9 1382240 (2), 15641590 (2), 8841956 (1), 8247323 (1) (see all 7)
    parkinsonism juvenile autosomal recessive 74.4 2 16722463 (1), 15571819 (1)
    motor neuron disease 72.6 30 16106222 (2), 16317257 (2), 1648124 (2), 15641590 (2) (see all 25)
    inclusion body myopathy 72.3 3 17279000 (1), 16104845 (1), 15732117 (1)
    lewy body disease 71.9 9 1668896 (2), 9464659 (1), 12647802 (1), 7912027 (1) (see all 8)
    amyotrophic lateral sclerosis 71.6 49 2169172 (2), 19938689 (2), 9083558 (2), 1646064 (2) (see all 39)


    Export disorders for RPS27A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RPS27A gene, integrated from 10 sources (see all 1828):
    (articles sorted by number of sources associating them with RPS27A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A map of 75 human ribosomal protein genes. (PubMed id 9582194)1, 2, 3 Kenmochi N.... Page D.C. (Genome Res. 1998)
    2. Effect of ubiquitin on platelet functions: possible identity with platelet activity suppressive lymphokine (PASL). (PubMed id 1657614)1, 2, 9 Pancre V.... Auriault C. (Eur. J. Immunol. 1991)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PubMed id 11875025)1, 2 Yoshihama M.... Kenmochi N. (Genome Res. 2002)
    5. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699)1, 2 Vladimirov S.N.... Otto A. (Eur. J. Biochem. 1996)
    6. Differential expression of translation-associated genes in benign and malignant human breast tumours. (PubMed id 1370760)1, 2 Adams S.M.... Varley J.M. (Br. J. Cancer 1992)
    7. Nucleotide sequence analysis of a cDNA encoding human ubiquitin reveals that ubiquitin is synthesized as a precursor. (PubMed id 2581967)1, 2 Lund P.K.... van Wyk J.J. (J. Biol. Chem. 1985)
    8. Structure of the human ubiquitin fusion gene Uba80 (RPS27a) and one of its pseudogenes. (PubMed id 10772958)1, 9 Kirschner L.S. and Stratakis C.A. (Biochem. Biophys. Res. Commun. 2000)
    9. The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells. (PubMed id 17203973)2, 9 Vasilescu J.... Figeys D. (J. Proteome Res. 2007)
    10. Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain. (PubMed id 16543144)2, 9 Huang F.... Sorkin A. (Mol. Cell 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6233 HGNC: 10417 AceView: RPS27A Ensembl:ENSG00000143947 euGenes: HUgn6233
    ECgene: RPS27A Kegg: 6233 H-InvDB: RPS27A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RPS27A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for RPS27A gene:
    Search GeneIP for patents involving RPS27A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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