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Aliases for RPS27 Gene

Aliases for RPS27 Gene

  • Ribosomal Protein S27 2 3 5
  • Metallopan-Stimulin 1 3 4
  • Metallopanstimulin 1 2 3
  • MPS-1 3 4
  • MPS1 3 4
  • Ribosomal Protein S27 (Metallopanstimulin 1) 2
  • 40S Ribosomal Protein S27 3
  • S27 3

External Ids for RPS27 Gene

Previous GeneCards Identifiers for RPS27 Gene

  • GC01P151780
  • GC01P149694
  • GC01P150738
  • GC01P151181
  • GC01P151182
  • GC01P150777
  • GC01P152229
  • GC01P153963
  • GC01P125325

Summaries for RPS27 Gene

Entrez Gene Summary for RPS27 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S27E family of ribosomal proteins. It contains a C4-type zinc finger domain that can bind to zinc. The encoded protein has been shown to be able to bind to nucleic acid. It is located in the cytoplasm as a ribosomal component, but it has also been detected in the nucleus. Studies in rat indicate that ribosomal protein S27 is located near ribosomal protein S18 in the 40S subunit and is covalently linked to translation initiation factor eIF3. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS27 Gene

RPS27 (Ribosomal Protein S27) is a Protein Coding gene. Diseases associated with RPS27 include Irregular Astigmatism and Diamond-Blackfan Anemia. Among its related pathways are Viral mRNA Translation and Signaling by GPCR. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome. An important paralog of this gene is RPS27L.

Gene Wiki entry for RPS27 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS27 Gene

Genomics for RPS27 Gene

Regulatory Elements for RPS27 Gene

Enhancers for RPS27 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around RPS27 on UCSC Golden Path with GeneCards custom track

Promoters for RPS27 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for RPS27 Gene

153,990,759 bp from pter
153,992,155 bp from pter
1,397 bases
Plus strand

Genomic View for RPS27 Gene

Genes around RPS27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS27 Gene

Proteins for RPS27 Gene

  • Protein details for RPS27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    40S ribosomal protein S27
    Protein Accession:
    Secondary Accessions:
    • Q5T4L6

    Protein attributes for RPS27 Gene

    84 amino acids
    Molecular mass:
    9461 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS27 Gene

neXtProt entry for RPS27 Gene

Post-translational modifications for RPS27 Gene

  • Ubiquitination at Lys 5
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS27 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPS27 Gene

Domains & Families for RPS27 Gene

Gene Families for RPS27 Gene

Protein Domains for RPS27 Gene

Suggested Antigen Peptide Sequences for RPS27 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein S27e family.
  • Belongs to the ribosomal protein S27e family.
genes like me logo Genes that share domains with RPS27: view

Function for RPS27 Gene

Molecular function for RPS27 Gene

GENATLAS Biochemistry:
60S ribosomal protein S27

Gene Ontology (GO) - Molecular Function for RPS27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 8908372
GO:0003735 structural constituent of ribosome IBA --
GO:0005515 protein binding IPI 21170087
GO:0008270 zinc ion binding NAS 8407955
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with RPS27: view
genes like me logo Genes that share phenotypes with RPS27: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS27 Gene

Localization for RPS27 Gene

Subcellular locations from

Jensen Localization Image for RPS27 Gene COMPARTMENTS Subcellular localization image for RPS27 gene
Compartment Confidence
cytosol 5
nucleus 5
extracellular 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPS27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 8407955
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0005840 ribosome NAS 8908372
GO:0022627 cytosolic small ribosomal subunit IEA,IDA 8706699
genes like me logo Genes that share ontologies with RPS27: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS27 Gene

Pathways & Interactions for RPS27 Gene

SuperPathways for RPS27 Gene

Superpath Contained pathways
1 Viral mRNA Translation
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Cell Cycle, Mitotic
4 Influenza Viral RNA Transcription and Replication
5 Mitotic Metaphase and Anaphase
genes like me logo Genes that share pathways with RPS27: view

Pathways by source for RPS27 Gene

Gene Ontology (GO) - Biological Process for RPS27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000028 ribosomal small subunit assembly IBA --
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation NAS 8908372
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPS27: view

No data available for SIGNOR curated interactions for RPS27 Gene

Drugs & Compounds for RPS27 Gene

(2) Drugs for RPS27 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
genes like me logo Genes that share compounds with RPS27: view

Transcripts for RPS27 Gene

mRNA/cDNA for RPS27 Gene

Unigene Clusters for RPS27 Gene

Ribosomal protein S27:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS27 Gene

No ASD Table

Relevant External Links for RPS27 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS27 Gene

mRNA expression in normal human tissues for RPS27 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RPS27 Gene

Protein tissue co-expression partners for RPS27 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS27 Gene:


SOURCE GeneReport for Unigene cluster for RPS27 Gene:


mRNA Expression by UniProt/SwissProt for RPS27 Gene:

Tissue specificity: Expressed in a wide variety of actively proliferating cells and tumor tissues.
genes like me logo Genes that share expression patterns with RPS27: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for RPS27 Gene

Orthologs for RPS27 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS27 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPS27 34
  • 94.84 (n)
  • 100 (a)
-- 35
  • 95 (a)
RPS27 35
  • 100 (a)
(Canis familiaris)
Mammalia RPS27 34
  • 88.89 (n)
  • 100 (a)
RPS27 35
  • 100 (a)
RPS27 35
  • 98 (a)
(Pan troglodytes)
Mammalia RPS27 34
  • 100 (n)
  • 100 (a)
RPS27 35
  • 100 (a)
RPS27 35
  • 100 (a)
(Rattus norvegicus)
Mammalia Rps27 34
  • 96.03 (n)
  • 100 (a)
(Monodelphis domestica)
Mammalia RPS27 35
  • 98 (a)
(Mus musculus)
Mammalia Gm9846 35
  • 100 (a)
Rps27 35
  • 100 (a)
(Anolis carolinensis)
Reptilia RPS27 35
  • 100 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rps27 34
  • 80.16 (n)
  • 96.43 (a)
(Danio rerio)
Actinopterygii -- 34
rps27.2 34
  • 80.95 (n)
  • 97.62 (a)
rps27.1 35
  • 96 (a)
rps27.2 35
  • 98 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10423 36
  • 85 (a)
RpS27 34
  • 73.98 (n)
  • 85.37 (a)
RpS27 35
  • 82 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007157 34
  • 74.21 (n)
  • 85.71 (a)
(Caenorhabditis elegans)
Secernentea rps-27 34
  • 68.27 (n)
  • 79.52 (a)
rps-27 35
  • 78 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR065C 34
  • 61.79 (n)
  • 74.39 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E11661g 34
  • 58.94 (n)
  • 71.95 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS27B 34
  • 62.6 (n)
  • 71.95 (a)
RPS27A 35
  • 70 (a)
RPS27B 35
  • 71 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G47930 34
  • 71.86 (n)
  • 81.82 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7575 34
(Hordeum vulgare)
Liliopsida Hv.190 34
(Oryza sativa)
Liliopsida Os02g0478700 34
  • 72.29 (n)
  • 83.12 (a)
(Zea mays)
Liliopsida Zm.7093 34
bread mold
(Neurospora crassa)
Ascomycetes NCU00618 34
  • 65.85 (n)
  • 79.27 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps27 34
  • 67.07 (n)
  • 75.9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10862 35
  • 96 (a)
Species where no ortholog for RPS27 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS27 Gene

Gene Tree for RPS27 (if available)
Gene Tree for RPS27 (if available)

Paralogs for RPS27 Gene

Paralogs for RPS27 Gene

(2) SIMAP similar genes for RPS27 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RPS27: view

Variants for RPS27 Gene

Sequence variations from dbSNP and Humsavar for RPS27 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2632 -- 153,991,545(+) AAAAA(A/T)GTTAT intron-variant
rs2633 -- 153,991,514(+) AAGTG(A/C)AGGAA intron-variant
rs6668510 -- 153,989,878(+) caaga(C/G)caaaa upstream-variant-2KB
rs12563539 -- 153,989,308(+) gcagc(A/G)gcgcg upstream-variant-2KB
rs12563772 -- 153,989,749(+) tagcc(A/G)ggcat upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPS27 Gene

Variant ID Type Subtype PubMed ID
nsv946401 CNV duplication 23825009

Variation tolerance for RPS27 Gene

Residual Variation Intolerance Score: 48.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 0.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS27 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS27 Gene

Disorders for RPS27 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RPS27 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
irregular astigmatism
diamond-blackfan anemia
  • diamond-blackfan anemia 1
- elite association - COSMIC cancer census association via MalaCards
Search RPS27 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RPS27

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RPS27: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS27 Gene

Publications for RPS27 Gene

  1. Primary structures and sequence analysis of human ribosomal proteins L39 and S27. (PMID: 8908372) Tsui S.K.W. … Lee C.Y. (Biochem. Mol. Biol. Int. 1996) 2 3 4 22 65
  2. A growth factor-inducible gene encodes a novel nuclear protein with zinc finger structure. (PMID: 8407955) Fernandez-Pol J.A. … Hamilton P.D. (J. Biol. Chem. 1993) 2 3 4 22 65
  3. Extraribosomal function of metallopanstimulin-1: reducing paxillin in head and neck squamous cell carcinoma and inhibiting tumor growth. (PMID: 19642098) Dai Y. … Stack B.C. (Int. J. Cancer 2010) 3 22 65
  4. In vitro and in vivo evidence of metallopanstimulin-1 in gastric cancer progression and tumorigenicity. (PMID: 16914586) Wang Y.W. … Zhu Z.G. (Clin. Cancer Res. 2006) 3 22 65
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 65

Products for RPS27 Gene

Sources for RPS27 Gene

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