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RPS27 Gene

protein-coding   GIFtS: 60
GCID: GC01P153963

Ribosomal Protein S27

(Previous name: ribosomal protein S27 (metallopanstimulin 1))
  Search for RPS27
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Ribosomal Protein S271 2     MPS-12 3
MPS12 3 5     Ribosomal Protein S27 (Metallopanstimulin 1)1
Metallopanstimulin 11 2     40S Ribosomal Protein S272
Metallopan-Stimulin 12 3     S272

External Ids:    HGNC: 104161   Entrez Gene: 62322   Ensembl: ENSG000001779547   OMIM: 6037025   UniProtKB: P426773   
ORGUL members:         

Export aliases for RPS27 gene to outside databases

Previous GC identifers: GC01P151780 GC01P149694 GC01P150738 GC01P151181 GC01P151182 GC01P150777 GC01P152229 GC01P125325


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RPS27 Gene:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This
gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S27E family
of ribosomal proteins. It contains a C4-type zinc finger domain that can bind to zinc. The encoded protein has
been shown to be able to bind to nucleic acid. It is located in the cytoplasm as a ribosomal component, but it
has also been detected in the nucleus. Studies in rat indicate that ribosomal protein S27 is located near
ribosomal protein S18 in the 40S subunit and is covalently linked to translation initiation factor eIF3. As is
typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed
through the genome. (provided by RefSeq, Jul 2008)

GeneCards Summary for RPS27 Gene:
RPS27 (ribosomal protein S27) is a protein-coding gene. GO annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is RPS27L.

Gene Wiki entry for RPS27 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPS27 gene promoter:
         AP-2gamma   C/EBPalpha   PPAR-gamma1   POU2F1   POU2F1a   AP-2beta   ZIC2/Zic2   PPAR-gamma2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPS27 promoter sequence
   Search Chromatin IP Primers for RPS27

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPS27


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21

RPS27 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS27 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P153963:  view genomic region     (about GC identifiers)

Start:
153,963,235 bp from pter      End:
153,964,631 bp from pter
Size:
1,397 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RS27_HUMAN, P42677 (See protein sequence)
Recommended Name: 40S ribosomal protein S27  
Size: 84 amino acids; 9461 Da
Cofactor: Binds 1 zinc ion per subunit (Potential)
Caution: Was originally (PubMed:8407955) thought to be a protein that could have played a role as a potentially
important mediator of cellular proliferative responses to various growth factors and other environmental signals.
Capable of specific binding to a cAMP response element in DNA
1 PDB 3D structure from and Proteopedia for RPS27:
3J3A (3D)    
Secondary accessions: Q5T4L6

Explore the universe of human proteins at neXtProt for RPS27: NX_P42677

Explore proteomics data for RPS27 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys5, Lys16
  • Modification sites at PhosphoSitePlus

  • See RPS27 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001021.1  
    ENSEMBL proteins: 
     ENSP00000357555   ENSP00000376341  
    Reactome Protein details: P42677

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RPS: S ribosomal proteins

    3 InterPro protein domains:
     IPR000592 Ribosomal_S27e
     IPR011332 Ribosomal_zn-bd
     IPR023407 Ribosomal_S27e_Zn-bd_dom

    Graphical View of Domain Structure for InterPro Entry P42677

    ProtoNet protein and cluster: P42677

    1 Blocks protein domain: IPB000592 Ribosomal protein S27E

    UniProtKB/Swiss-Prot: RS27_HUMAN, P42677
    Similarity: Belongs to the ribosomal protein S27e family


    Find genes that share domains with RPS27           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for RPS27:
    60S ribosomal protein S27

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS8908372
    GO:0003735structural constituent of ribosome IEA--
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding NAS8407955
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with RPS27           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for RPS27:
     Nuclear pre-40S maturation def  Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RPS27
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    miRNA
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    miRTarBase miRNAs that target RPS27:
    hsa-mir-100-5p (MIRT048465), hsa-mir-16-5p (MIRT031378), hsa-mir-877-5p (MIRT037255), hsa-mir-331-3p (MIRT043408), hsa-mir-455-3p (MIRT037843), hsa-mir-320a (MIRT044612), hsa-let-7e-5p (MIRT051425), hsa-mir-502-3p (MIRT037982), hsa-mir-636 (MIRT039575), hsa-mir-20a-5p (MIRT050605)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5
    extracellular3
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA8407955
    GO:0005829cytosol TAS--
    GO:0005840ribosome NAS8908372
    GO:0022627cytosolic small ribosomal subunit IDA15883184

    Find genes that share ontologies with RPS27           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RPS27 About   (see all 9)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CFTR translational fidelity class I mutations
    CFTR translational fidelity class I mutations 0.60
    Ribosome0.54
    Cytoplasmic Ribosomal Proteins0.60
    2Influenza Viral RNA Transcription and Replication
    Viral mRNA Translation0.94
    Eukaryotic Translation Initiation0.89
    Peptide chain elongation0.94
    Cap-dependent Translation Initiation0.89
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    Formation of a pool of free 40S subunits0.94
    Nonsense-Mediated Decay0.89
    3Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
    Translation initiation complex formation0.91
    Ribosomal scanning and start codon recognition0.91
    Formation of the ternary complex, and subsequently, the 43S complex0.91
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.90
    4Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    5Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90


    Find genes that share SuperPaths with RPS27           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPS27
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPS27
        Cytoplasmic Ribosomal Proteins


    Selected Reactome Pathways for RPS27 (see all 15)
        Peptide chain elongation
    Formation of the ternary complex, and subsequently, the 43S complex
    Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
    Resolution of Sister Chromatid Cohesion
    Viral mRNA Translation


    1 Kegg Pathway  (Kegg details for RPS27):
        Ribosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RPS27
    Interactions:

        GeneGlobe Interaction Network for RPS27

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPS27 (P426771, 2, 3 ENSP000003575554) via UniProtKB, MINT, STRING, and/or I2D (see all 226)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MARSP561922, 3, ENSP000002620274MINT-8269340 I2D: score=2 STRING: ENSP00000262027
    RTN4Q9NQC32, 3, ENSP000003378384MINT-8269373 I2D: score=2 STRING: ENSP00000337838
    MDM2Q009871, 3, ENSP000004172814EBI-356336,EBI-389668 I2D: score=1 STRING: ENSP00000417281
    C2orf44Q9H6R72, 3MINT-8269307 I2D: score=2 
    HMP19Q9Y3282, 3MINT-8269329 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--

    Find genes that share ontologies with RPS27           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPS27 (RS27)

    1 HMDB Compound for RPS27    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    1 Novoseek inferred chemical compound relationship for RPS27 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 55.8 12 9404850 (1), 10556717 (1), 9179190 (1), 9216656 (1) (see all 10)



    Find genes that share compounds with RPS27           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RPS27 gene: 
    NM_001030.4  

    Unigene Clusters for RPS27:

    Ribosomal protein S27
    Hs.546291  [show with all ESTs], Hs.654475  [show with all ESTs]
    Unigene Representative Sequences: BQ278503, CD556147
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368567(uc001fdv.3) ENST00000392558 ENST00000493224 ENST00000477151

    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat RPS27

    Additional mRNA sequence: 

    AK312070.1 BC002658.2 L19739.1 

    Selected DOTS entries (see all 104):

    DT.121136986  DT.40227959  DT.95143195  DT.100739076  DT.97849623  DT.95115492  DT.100739067  DT.100739063 
    DT.101955243  DT.102843142  DT.100739085  DT.120925364  DT.100739080  DT.92007476  DT.91649976  DT.120925355 
    DT.85101639  DT.121136915  DT.121353864  DT.121403566  DT.121353935  DT.121353870  DT.91741299  DT.100739062 

    Selected AceView cDNA sequences (see all 1610):

    BE733602 AI253696 AI707951 AA299920 AA935542 AA352927 CB134016 AA669227 
    BM769928 F27408 BM841495 BQ892648 AA328706 CB133658 BQ376688 BM773448 
    CB138999 T53711 CD108061 AA757556 BM759095 CB110733 AI720149 CB121742 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RPS27 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACAAACGGT
    RPS27 Expression
    About this image


    RPS27 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Neurons
             Adult Dopaminergic Neurons Ventral Tegmental Area
     
     Endoderm (Gastrulation Derivatives)
             Endoderm-like cells
     
     Brain (Nervous System)
             Adult Dopaminergic Neurons Ventral Tegmental Area
     
     Thymus (Hematopoietic System)
    RPS27 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPS27 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.546291 Hs.654475

    UniProtKB/Swiss-Prot: RS27_HUMAN, P42677
    Tissue specificity: Expressed in a wide variety of actively proliferating cells and tumor tissues

        Custom PCR Arrays for RPS27
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS27

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPS27 gene from Selected species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rps275 ribosomal protein S27   --   3 (39.21 cM) 90212725 
    lizard
    (Anolis carolinensis)
    Reptilia RPS276
    ribosomal protein S27
    100(a)
    1 ↔ 1
    GL343805.1(101551-103790)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC053815.12   -- 83.39(n)    BC053815.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC059595.12   -- 81.54(n)   393738  BC059595.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG104233
    RpS271
    structural constituent of ribosome3
    Ribosomal protein S271
    85(a)3
    73.98(n)1
    85.37(a)1
      96C83
    430391  NM_143102.21  NP_651359.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rps-271 rps-27 68.27(n)
    79.52(a)
      178538  NM_070733.5  NP_503134.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPS27B1 RPS27B 62.6(n)
    71.95(a)
      856415   NP_011885.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G479301 AT5G47930 71.86(n)
    81.82(a)
      834844  NM_124167.3  NP_199604.1 
    rice
    (Oryza sativa)
    Liliopsida CA755866.12   -- 76.22(n)    CA755866.1 


    ENSEMBL Gene Tree for RPS27 (if available)
    TreeFam Gene Tree for RPS27 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RPS27 gene
    RPS27L2  
    2 SIMAP similar genes for RPS27 using alignment to 2 protein entries:     RS27_HUMAN (see all proteins):
    RPS27L    LOC392748

    Find genes that share paralogs with RPS27           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for RPS27 (see all 14)
    PGOHUM00000238887 PGOHUM00000242928 PGOHUM00000239423 PGOHUM00000239492 PGOHUM00000246677


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RPS27 (see all 97)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1399199471,2
    --153961388(+) CAACCG/TTTGTT 1 -- us2k10--------
    rs125635391,2
    C,F,H--153961784(+) gcagcG/Agcgcg 1 -- us2k11Minor allele frequency- A:0.50NA 4
    rs1842140931,2
    --153961955(+) CTCCTA/GACCTC 1 -- us2k10--------
    rs1891363831,2
    --153962200(+) CCCGTC/TTCTAC 1 -- us2k10--------
    rs125637721,2
    H--153962225(+) tagccA/Gggcat 1 -- us2k10--------
    rs125649211,2
    H--153962229(+) cgggcA/Gtggtg 1 -- us2k10--------
    rs1458903161,2
    --153962299(+) GGAGGC/TGGAGG 1 -- us2k10--------
    rs1484004771,2
    --153962327(+) GGCGCC/TATCAC 1 -- us2k10--------
    rs1439939031,2
    --153962372(+) TAAAAA/TAAAAA 1 -- us2k10--------
    rs1464398891,2
    --153962468(+) CTATTC/TAATCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RPS27 (153963235 - 153964631 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for RPS27: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RPS27
    DNA2.0 Custom Variant and Variant Library Synthesis for RPS27

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603702    OMIM disorders: --


    Find genes that share disorders with RPS27           About GenesLikeMe

    7 Novoseek inferred disease relationships for RPS27 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hnscc 58.6 9 15598348 (3), 14732777 (2), 19642098 (2)
    tumors 19.9 14 19642098 (3), 9404850 (1), 9179190 (1), 9216656 (1) (see all 9)
    carcinoma squamous cell 17.8 3 19642098 (2), 15598348 (1)
    cancer 17.2 13 19642098 (2), 12175529 (2), 16299651 (2), 10556717 (1) (see all 8)
    melanoma 17.2 7 9404850 (3), 18071315 (3), 8407955 (1)
    gastric cancer 14.4 19 16914586 (7), 16299651 (4)
    carcinoma 0 1 8407955 (1)


    Export disorders for RPS27 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RPS27 gene, integrated from 10 sources (see all 76):
    (articles sorted by number of sources associating them with RPS27)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A growth factor-inducible gene encodes a novel nuclear protein with zinc finger structure. (PubMed id 8407955)1, 2, 3, 9 Fernandez-Pol J.A.... Hamilton P.D. (J. Biol. Chem. 1993)
    2. Primary structures and sequence analysis of human ribosomal proteins L39 and S27. (PubMed id 8908372)1, 2, 3, 9 Tsui S.K.W.... Lee C.Y. (Biochem. Mol. Biol. Int. 1996)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PubMed id 11875025)1, 2 Yoshihama M.... Kenmochi N. (Genome Res. 2002)
    6. A map of 75 human ribosomal protein genes. (PubMed id 9582194)1, 2 Kenmochi N.... Page D.C. (Genome Res. 1998)
    7. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699)1, 2 Vladimirov S.N.... Otto A. (Eur. J. Biochem. 1996)
    8. In vitro and in vivo evidence of metallopanstimulin-1 in gastric cancer progression and tumorigenicity. (PubMed id 16914586)1, 9 Wang Y.W....Zhu Z.G. (Clin. Cancer Res. 2006)
    9. Extraribosomal function of metallopanstimulin-1: reducing paxillin in head and neck squamous cell carcinoma and inhibiting tumor growth. (PubMed id 19642098)1, 9 Dai Y....Stack B.C. (Int. J. Cancer 2010)
    10. Metallopanstimulin gene product produced in a baculovirus expression system is a nuclear phosphoprotein that binds to DNA. (PubMed id 7986747)1, 9 Fernandez-Pol J.A....Hamilton P.D. (amp 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6232 HGNC: 10416 AceView: RPS27 Ensembl:ENSG00000177954 euGenes: HUgn6232
    ECgene: RPS27 Kegg: 6232 H-InvDB: RPS27

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RPS27 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RPS27 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RPS27 gene:
    Search GeneIP for patents involving RPS27

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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