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Aliases for RPS26 Gene

Aliases for RPS26 Gene

  • Ribosomal Protein S26 2 3 5
  • Small Ribosomal Subunit Protein ES26 3 4
  • 40S Ribosomal Protein S26 2 3
  • DBA10 3
  • S26 3

External Ids for RPS26 Gene

Previous GeneCards Identifiers for RPS26 Gene

  • GC13M099552
  • GC12P056999
  • GC12P056152
  • GC12P054721
  • GC12P054722
  • GC12P056438
  • GC07P121716

Summaries for RPS26 Gene

Entrez Gene Summary for RPS26 Gene

  • This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S26E family of ribosomal proteins. Mutations in this gene are found in Diamond-Blackfan anemia 10. There are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Aug 2017]

GeneCards Summary for RPS26 Gene

RPS26 (Ribosomal Protein S26) is a Protein Coding gene. Diseases associated with RPS26 include Diamond-Blackfan Anemia 10 and Diamond-Blackfan Anemia 15 With Mandibulofacial Dysostosis. Among its related pathways are Viral mRNA Translation and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. Gene Ontology (GO) annotations related to this gene include mRNA binding.

Gene Wiki entry for RPS26 Gene

Additional gene information for RPS26 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS26 Gene

Genomics for RPS26 Gene

GeneHancer (GH) Regulatory Elements for RPS26 Gene

Promoters and enhancers for RPS26 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I056040 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 556.6 +0.1 146 3.3 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 RPS26 LOC105369780 BAZ2A RN7SL809P STAT2 PAN2 ENSG00000258199 ZC3H10 CDK2 ENSG00000257740
GH12I056009 Enhancer 1.1 ENCODE dbSUPER 20.6 -31.1 -31097 3.2 FOXA2 ARID4B TCF12 ZNF766 ATF7 SP5 PPARG NFIL3 MIER3 ATF4 RAB5B PMEL RPS26 CDK2 PA2G4 ORMDL2 SARNP IKZF4 LOC105369781
GH12I056016 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 9.9 -21.5 -21470 6.8 HDGF PKNOX1 ATF1 SIN3A ARID2 RXRA GTF2B REST ZNF592 MEF2D IKZF4 RAB5B BAZ2A PMEL PYM1 RN7SL809P DNAJC14 STAT2 RPS26 LOC105369781
GH12I055970 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 9.4 -68.9 -68916 5.1 ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 PMEL RAB5B BAZ2A DNAJC14 ZC3H10 ENSG00000258199 ENSG00000258317 TMEM198B CDK2 ENSG00000257740
GH12I056006 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 10 -34.1 -34145 1.8 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 POLR2B IKZF4 SUOX DNAJC14 ZC3H10 ENSG00000258317 HSPD1P4 ZBTB39 ENSG00000257740 PA2G4 ENSG00000258199
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RPS26 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPS26 gene promoter:

Genomic Locations for RPS26 Gene

Genomic Locations for RPS26 Gene
chr12:56,041,853-56,044,675
(GRCh38/hg38)
Size:
2,823 bases
Orientation:
Plus strand
chr12:56,435,637-56,438,116
(GRCh37/hg19)

Genomic View for RPS26 Gene

Genes around RPS26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS26 Gene

Proteins for RPS26 Gene

  • Protein details for RPS26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62854-RS26_HUMAN
    Recommended name:
    40S ribosomal protein S26
    Protein Accession:
    P62854
    Secondary Accessions:
    • P02383
    • P70394
    • Q06722
    • Q3MHD8
    • Q6IRY4

    Protein attributes for RPS26 Gene

    Size:
    115 amino acids
    Molecular mass:
    13015 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS26 Gene

neXtProt entry for RPS26 Gene

Post-translational modifications for RPS26 Gene

No Post-translational modifications

Other Protein References for RPS26 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPS26 Gene

Domains & Families for RPS26 Gene

Gene Families for RPS26 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPS26 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RPS26 Gene

Graphical View of Domain Structure for InterPro Entry

P62854

UniProtKB/Swiss-Prot:

RS26_HUMAN :
  • Belongs to the eukaryotic ribosomal protein eS26 family.
Family:
  • Belongs to the eukaryotic ribosomal protein eS26 family.
genes like me logo Genes that share domains with RPS26: view

Function for RPS26 Gene

Molecular function for RPS26 Gene

GENATLAS Biochemistry:
40S ribosomal protein S26,12kDa

Phenotypes From GWAS Catalog for RPS26 Gene

Gene Ontology (GO) - Molecular Function for RPS26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA,HDA 22658674
GO:0003729 mRNA binding IDA 15716004
GO:0003735 structural constituent of ribosome IBA --
GO:0005515 protein binding IPI 16189514
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with RPS26: view
genes like me logo Genes that share phenotypes with RPS26: view

Human Phenotype Ontology for RPS26 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS26 Gene

Localization for RPS26 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS26 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Endoplasmic reticulum (4)
  • Nucleoli (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPS26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
GO:0015935 small ribosomal subunit HDA,IDA 15883184
genes like me logo Genes that share ontologies with RPS26: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS26 Gene

Pathways & Interactions for RPS26 Gene

SuperPathways for RPS26 Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
.55
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing in the nucleus and cytosol
5 HIV Life Cycle
.45
genes like me logo Genes that share pathways with RPS26: view

Gene Ontology (GO) - Biological Process for RPS26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,IC 8706699
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPS26: view

No data available for SIGNOR curated interactions for RPS26 Gene

Drugs & Compounds for RPS26 Gene

No Compound Related Data Available

Transcripts for RPS26 Gene

mRNA/cDNA for RPS26 Gene

Unigene Clusters for RPS26 Gene

Ribosomal protein S26:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS26 Gene

No ASD Table

Relevant External Links for RPS26 Gene

GeneLoc Exon Structure for
RPS26
ECgene alternative splicing isoforms for
RPS26

Expression for RPS26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPS26 Gene

Protein differential expression in normal tissues from HIPED for RPS26 Gene

This gene is overexpressed in Pancreas (14.8) and Lung (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPS26 Gene



Protein tissue co-expression partners for RPS26 Gene

NURSA nuclear receptor signaling pathways regulating expression of RPS26 Gene:

RPS26

SOURCE GeneReport for Unigene cluster for RPS26 Gene:

Hs.447562

Evidence on tissue expression from TISSUES for RPS26 Gene

  • Nervous system(4.8)
  • Liver(4.5)
  • Muscle(3)
  • Blood(2.8)
  • Intestine(2.6)
  • Stomach(2.6)
  • Heart(2.5)
  • Kidney(2.5)
  • Lung(2.5)
  • Spleen(2.5)
  • Pancreas(2.4)
  • Adrenal gland(2.2)
  • Lymph node(2.2)
  • Thyroid gland(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS26 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Organs:
Head and neck:
  • brain
  • cheek
  • chin
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • head
  • inner ear
  • jaw
  • lip
  • mandible
  • maxilla
  • middle ear
  • mouth
  • neck
  • nose
  • outer ear
  • skull
Thorax:
  • aorta
  • chest wall
  • clavicle
  • heart
  • heart valve
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • intestine
  • kidney
  • large intestine
Pelvis:
  • pelvis
  • penis
  • ureter
  • urethra
  • urinary bladder
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • peripheral nervous system
  • red blood cell
  • skin
  • spinal column
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with RPS26: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS26 Gene

Orthologs for RPS26 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS26 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Rps26-ps1 34
  • 100 (a)
OneToMany
Rps26 33 16 34
  • 86.09 (n)
chimpanzee
(Pan troglodytes)
Mammalia RPS26 33 34 34
  • 99.71 (n)
cow
(Bos Taurus)
Mammalia RPS26 33 34
  • 93.04 (n)
dog
(Canis familiaris)
Mammalia RPS26 33 34
  • 89.57 (n)
rat
(Rattus norvegicus)
Mammalia LOC100360508 33
  • 87.54 (n)
oppossum
(Monodelphis domestica)
Mammalia RPS26 34
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPS26 33 34
  • 82.32 (n)
lizard
(Anolis carolinensis)
Reptilia RPS26 34
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rps26 33
  • 79.54 (n)
Str.403 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.8381 33
zebrafish
(Danio rerio)
Actinopterygii rps26 34
  • 93 (a)
OneToMany
rps26l 33 34
  • 81.19 (n)
-- 33
fruit fly
(Drosophila melanogaster)
Insecta RpS26 35 33 34
  • 71.67 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta RS26_ANOGA 33
  • 66.67 (n)
worm
(Caenorhabditis elegans)
Secernentea rps-26 33 34
  • 66.67 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS26B 33 34
  • 63.7 (n)
RPS26A 34 36
  • 62 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR194W 33
  • 63.67 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D05115g 33
  • 63.04 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G40510 33
  • 62.71 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04552 33
  • 69.33 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps2602 33
  • 62.33 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 57 (a)
OneToOne
Species where no ortholog for RPS26 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS26 Gene

ENSEMBL:
Gene Tree for RPS26 (if available)
TreeFam:
Gene Tree for RPS26 (if available)

Paralogs for RPS26 Gene

(1) SIMAP similar genes for RPS26 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RPS26: view

No data available for Paralogs for RPS26 Gene

Variants for RPS26 Gene

Sequence variations from dbSNP and Humsavar for RPS26 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1131017 benign, Diamond-Blackfan anemia 56,042,145(+) C/G/T 5_prime_UTR_variant
rs143951267 pathogenic, Diamond-Blackfan anemia 10 56,042,167(+) A/G/T initiator_codon_variant, missense_variant
rs148622862 pathogenic, Diamond-Blackfan anemia 10 56,042,170(+) G/A splice_donor_variant
rs148942765 pathogenic, Diamond-Blackfan anemia 10, Diamond-Blackfan anemia 15 with mandibulofacial dysostosis 56,043,440(+) C/A/T coding_sequence_variant, stop_gained, synonymous_variant
rs17118262 benign, Diamond-Blackfan anemia 56,042,136(+) C/G/T 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for RPS26 Gene

Variant ID Type Subtype PubMed ID
nsv1051961 CNV gain 25217958
nsv832424 CNV loss 17160897
nsv832427 CNV loss 17160897
nsv973074 CNV duplication 23825009

Variation tolerance for RPS26 Gene

Residual Variation Intolerance Score: 47.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 0.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPS26 Gene

Human Gene Mutation Database (HGMD)
RPS26
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPS26

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS26 Gene

Disorders for RPS26 Gene

MalaCards: The human disease database

(8) MalaCards diseases for RPS26 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search RPS26 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

RS26_HUMAN
  • Diamond-Blackfan anemia 10 (DBA10) [MIM:613309]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. {ECO:0000269 PubMed:20116044, ECO:0000269 PubMed:24942156}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for RPS26

genes like me logo Genes that share disorders with RPS26: view

No data available for Genatlas for RPS26 Gene

Publications for RPS26 Gene

  1. Isolation, structural analysis and mapping of the functional gene of human ribosomal protein S26. (PMID: 9602156) Filipenko ML … Amaldi F (Gene 1998) 3 4 22 58
  2. [Mapping of the genes for ribosomal proteins S26, L19, and L32 on human chromosomes]. (PMID: 8670309) Filipenko ML … Mertvetsov NP (Bioorganicheskaia khimiia 1995) 2 3 22 58
  3. [Cloning cDNA of human S26 ribosomal protein and determination of its primary structure]. (PMID: 7945460) Filipenko ML … Mertvetsov NP (Bioorganicheskaia khimiia 1994) 3 4 22 58
  4. A new system for naming ribosomal proteins. (PMID: 24524803) Ban N … Yusupov M (Current opinion in structural biology 2014) 3 4 58
  5. Diamond-Blackfan anemia with mandibulofacial dystostosis is heterogeneous, including the novel DBA genes TSR2 and RPS28. (PMID: 24942156) Gripp KW … Sol-Church K (American journal of medical genetics. Part A 2014) 3 4 58

Products for RPS26 Gene

Sources for RPS26 Gene

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