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Aliases for RPS26 Gene

Aliases for RPS26 Gene

  • Ribosomal Protein S26 2 3 5
  • 40S Ribosomal Protein S26 2 3
  • DBA10 3
  • S26 3

External Ids for RPS26 Gene

Previous GeneCards Identifiers for RPS26 Gene

  • GC13M099552
  • GC12P056999
  • GC12P056152
  • GC12P054721
  • GC12P054722
  • GC12P056438
  • GC07P121716

Summaries for RPS26 Gene

Entrez Gene Summary for RPS26 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S26E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS26 Gene

RPS26 (Ribosomal Protein S26) is a Protein Coding gene. Diseases associated with RPS26 include Diamond-Blackfan Anemia 10 and Rps26-Related Diamond-Blackfan Anemia. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Metabolism. GO annotations related to this gene include poly(A) RNA binding and mRNA binding.

Gene Wiki entry for RPS26 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS26 Gene

Genomics for RPS26 Gene

Regulatory Elements for RPS26 Gene

Enhancers for RPS26 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F056071 0.2 ENCODE 11.1 +29.9 29889 0.1 SOX13 ZNF121 CEBPA BHLHE40 CEBPG RARA TEAD3 PA2G4 RPS26 RPL41 ZC3H10 IKZF4 SUOX SMARCC2 ERBB3
GH12F055955 1 Ensembl ENCODE 10.4 -84.8 -84832 4.0 CBX3 PKNOX1 RAD21 ZEB1 RFX5 GLIS2 RCOR1 FOS DEK ZNF362 DGKA RPS26 ORMDL2 SARNP MMP19 RDH5 MYL6B CDK2 PYM1
GH12F056006 0.5 ENCODE 10 -34.1 -34134 1.8 PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF302 ZNF207 ZNF143 SUOX ENSG00000258199 ZC3H10 ENSG00000258317 PA2G4 BAZ2A RPS26 IKZF4 LOC105369781
GH12F056016 0.5 ENCODE 9.9 -21.5 -21471 6.8 TBP HDGF ATF1 PKNOX1 SCRT2 KDM4B EGR2 SMARCA5 ZBTB2 GTF2B RAB5B BAZ2A PMEL RN7SL809P STAT2 RPS26 LOC105369781 LOC105369780
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RPS26 on UCSC Golden Path with GeneCards custom track

Promoters for RPS26 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000431190 247 2201 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263

Genomic Location for RPS26 Gene

56,041,853 bp from pter
56,044,675 bp from pter
2,823 bases
Plus strand

Genomic View for RPS26 Gene

Genes around RPS26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS26 Gene

Proteins for RPS26 Gene

  • Protein details for RPS26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    40S ribosomal protein S26
    Protein Accession:
    Secondary Accessions:
    • P02383
    • P70394
    • Q06722
    • Q3MHD8
    • Q6IRY4

    Protein attributes for RPS26 Gene

    115 amino acids
    Molecular mass:
    13015 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS26 Gene

neXtProt entry for RPS26 Gene

Post-translational modifications for RPS26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPS26 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPS26 Gene

Domains & Families for RPS26 Gene

Gene Families for RPS26 Gene

Protein Domains for RPS26 Gene


Suggested Antigen Peptide Sequences for RPS26 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein S26e family.
  • Belongs to the ribosomal protein S26e family.
genes like me logo Genes that share domains with RPS26: view

Function for RPS26 Gene

Molecular function for RPS26 Gene

GENATLAS Biochemistry:
40S ribosomal protein S26,12kDa

Gene Ontology (GO) - Molecular Function for RPS26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003729 mRNA binding IDA 15716004
GO:0003735 structural constituent of ribosome IBA --
GO:0005515 protein binding IPI 16189514
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0098641 cadherin binding involved in cell-cell adhesion IDA 25468996
genes like me logo Genes that share ontologies with RPS26: view
genes like me logo Genes that share phenotypes with RPS26: view

Human Phenotype Ontology for RPS26 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS26 Gene

Localization for RPS26 Gene

Subcellular locations from

Jensen Localization Image for RPS26 Gene COMPARTMENTS Subcellular localization image for RPS26 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPS26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RPS26: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS26 Gene

Pathways & Interactions for RPS26 Gene

SuperPathways for RPS26 Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing in the nucleus and cytosol
5 HIV Life Cycle
genes like me logo Genes that share pathways with RPS26: view

Gene Ontology (GO) - Biological Process for RPS26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IC 8706699
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPS26: view

No data available for SIGNOR curated interactions for RPS26 Gene

Transcripts for RPS26 Gene

mRNA/cDNA for RPS26 Gene

Unigene Clusters for RPS26 Gene

Ribosomal protein S26:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS26 Gene

No ASD Table

Relevant External Links for RPS26 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS26 Gene

mRNA expression in normal human tissues for RPS26 Gene

Protein differential expression in normal tissues from HIPED for RPS26 Gene

This gene is overexpressed in Pancreas (14.8) and Lung (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPS26 Gene

Protein tissue co-expression partners for RPS26 Gene

NURSA nuclear receptor signaling pathways regulating expression of RPS26 Gene:


SOURCE GeneReport for Unigene cluster for RPS26 Gene:

genes like me logo Genes that share expression patterns with RPS26: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS26 Gene

Orthologs for RPS26 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS26 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Rps26-ps1 35
  • 100 (a)
Rps26 34 16 35
  • 86.09 (n)
(Pan troglodytes)
Mammalia RPS26 34 35 35
  • 99.71 (n)
(Bos Taurus)
Mammalia RPS26 34 35
  • 93.04 (n)
(Canis familiaris)
Mammalia RPS26 34 35
  • 89.57 (n)
(Rattus norvegicus)
Mammalia Rps26 34
  • 87.54 (n)
(Monodelphis domestica)
Mammalia RPS26 35
  • 80 (a)
(Gallus gallus)
Aves RPS26 34 35
  • 82.32 (n)
(Anolis carolinensis)
Reptilia RPS26 35
  • 98 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rps26 34
  • 79.54 (n)
Str.403 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.8381 34
(Danio rerio)
Actinopterygii rps26 35
  • 93 (a)
rps26l 34 35
  • 81.19 (n)
-- 34
fruit fly
(Drosophila melanogaster)
Insecta RpS26 36 34 35
  • 71.67 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta RS26_ANOGA 34
  • 66.67 (n)
(Caenorhabditis elegans)
Secernentea rps-26 34 35
  • 66.67 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS26B 34 35
  • 63.7 (n)
RPS26A 35 37
  • 62 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR194W 34
  • 63.67 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D05115g 34
  • 63.04 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G40510 34
  • 62.71 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04552 34
  • 69.33 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps2602 34
  • 62.33 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 57 (a)
Species where no ortholog for RPS26 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS26 Gene

Gene Tree for RPS26 (if available)
Gene Tree for RPS26 (if available)

Paralogs for RPS26 Gene

(1) SIMAP similar genes for RPS26 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RPS26: view

No data available for Paralogs for RPS26 Gene

Variants for RPS26 Gene

Sequence variations from dbSNP and Humsavar for RPS26 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs267607023 Diamond-Blackfan anemia 10 (DBA10) [MIM:613309], Pathogenic 56,042,518(+) CCAAG(A/G)ACAAG upstream-variant-2KB, reference, missense
VAR_063581 Diamond-Blackfan anemia 10 (DBA10) [MIM:613309]
rs143951267 Pathogenic 56,042,167(+) CCAAG(A/G/T)TGGTG upstream-variant-2KB, reference, missense
rs148622862 Pathogenic 56,042,170(+) AGATG(A/G)TGAGT upstream-variant-2KB, splice-donor-variant
rs148942765 Pathogenic 56,043,440(+) GGAAT(A/C/T)GATCT upstream-variant-2KB, reference, synonymous-codon, stop-gained

Structural Variations from Database of Genomic Variants (DGV) for RPS26 Gene

Variant ID Type Subtype PubMed ID
nsv1051961 CNV gain 25217958
nsv832424 CNV loss 17160897
nsv832427 CNV loss 17160897
nsv973074 CNV duplication 23825009

Variation tolerance for RPS26 Gene

Residual Variation Intolerance Score: 47.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 0.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS26 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS26 Gene

Disorders for RPS26 Gene

MalaCards: The human disease database

(9) MalaCards diseases for RPS26 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
diamond-blackfan anemia 10
  • dba10
rps26-related diamond-blackfan anemia
  • dba10
diamond blackfan anemia 15 with mandibulofacial dysostosis
  • diamond-blackfan anemia 15, with mandibulofacial dysostosis
diamond-blackfan anemia
  • diamond-blackfan anemia 1
klippel-feil syndrome
  • autosomal dominant klippel-feil syndrome
- elite association - COSMIC cancer census association via MalaCards
Search RPS26 in MalaCards View complete list of genes associated with diseases


  • Diamond-Blackfan anemia 10 (DBA10) [MIM:613309]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. {ECO:0000269 PubMed:20116044, ECO:0000269 PubMed:24942156}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for RPS26

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RPS26: view

No data available for Genatlas for RPS26 Gene

Publications for RPS26 Gene

  1. Isolation, structural analysis and mapping of the functional gene of human ribosomal protein S26. (PMID: 9602156) Filipenko M.L. … Amaldi F. (Gene 1998) 3 4 22 64
  2. [Mapping of the genes for ribosomal proteins S26, L19, and L32 on human chromosomes]. (PMID: 8670309) Filipenko M.L. … Mertvetsov N.P. (Bioorg. Khim. 1995) 2 3 22 64
  3. Cloning cDNA of human S26 ribosomal protein and determination of its primary structure. (PMID: 7945460) Filipenko M.L. … Mertvetsov N.P. (Bioorg. Khim. 1994) 3 4 22 64
  4. Ribosomal protein genes RPS10 and RPS26 are commonly mutated in Diamond-Blackfan anemia. (PMID: 20116044) Doherty L. … Gazda H.T. (Am. J. Hum. Genet. 2010) 3 4 64
  5. Genome-wide association analysis identifies three psoriasis susceptibility loci. (PMID: 20953189) Stuart P.E. … Elder J.T. (Nat. Genet. 2010) 3 46 64

Products for RPS26 Gene

Sources for RPS26 Gene

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