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Aliases for RPS26 Gene

Aliases for RPS26 Gene

  • Ribosomal Protein S26 2 3 5
  • 40S Ribosomal Protein S26 2
  • DBA10 3
  • S26 3

External Ids for RPS26 Gene

Previous GeneCards Identifiers for RPS26 Gene

  • GC13M099552
  • GC12P056999
  • GC12P056152
  • GC12P054721
  • GC12P054722
  • GC12P056438
  • GC07P121716

Summaries for RPS26 Gene

Entrez Gene Summary for RPS26 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S26E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS26 Gene

RPS26 (Ribosomal Protein S26) is a Protein Coding gene. Diseases associated with RPS26 include Diamond-Blackfan Anemia 10 and Rps26-Related Diamond-Blackfan Anemia. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. GO annotations related to this gene include poly(A) RNA binding and mRNA binding.

Gene Wiki entry for RPS26 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS26 Gene

Genomics for RPS26 Gene

Regulatory Elements for RPS26 Gene

Enhancers for RPS26 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPS26 on UCSC Golden Path with GeneCards custom track

Promoters for RPS26 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPS26 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPS26 Gene

56,041,853 bp from pter
56,044,675 bp from pter
2,823 bases
Plus strand

Genomic View for RPS26 Gene

Genes around RPS26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS26 Gene

Proteins for RPS26 Gene

  • Protein details for RPS26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    40S ribosomal protein S26
    Protein Accession:
    Secondary Accessions:
    • P02383
    • P70394
    • Q06722
    • Q3MHD8
    • Q6IRY4

    Protein attributes for RPS26 Gene

    115 amino acids
    Molecular mass:
    13015 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS26 Gene

neXtProt entry for RPS26 Gene

Proteomics data for RPS26 Gene at MOPED

Post-translational modifications for RPS26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPS26 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPS26 Gene

Domains & Families for RPS26 Gene

Gene Families for RPS26 Gene

Protein Domains for RPS26 Gene


Suggested Antigen Peptide Sequences for RPS26 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein S26e family.
  • Belongs to the ribosomal protein S26e family.
genes like me logo Genes that share domains with RPS26: view

Function for RPS26 Gene

Molecular function for RPS26 Gene

GENATLAS Biochemistry:
40S ribosomal protein S26,12kDa

Gene Ontology (GO) - Molecular Function for RPS26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with RPS26: view
genes like me logo Genes that share phenotypes with RPS26: view

Human Phenotype Ontology for RPS26 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS26 Gene

Localization for RPS26 Gene

Subcellular locations from

Jensen Localization Image for RPS26 Gene COMPARTMENTS Subcellular localization image for RPS26 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPS26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005840 ribosome IEA --
GO:0015935 small ribosomal subunit IDA 15883184
GO:0016020 membrane IDA 19946888
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with RPS26: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS26 Gene

Pathways & Interactions for RPS26 Gene

SuperPathways for RPS26 Gene

Superpath Contained pathways
1 Viral mRNA Translation
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 Infectious disease
5 rRNA processing
genes like me logo Genes that share pathways with RPS26: view

Gene Ontology (GO) - Biological Process for RPS26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS --
GO:0006413 translational initiation TAS --
GO:0006415 translational termination TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
GO:0016032 viral process TAS --
genes like me logo Genes that share ontologies with RPS26: view

No data available for SIGNOR curated interactions for RPS26 Gene

Drugs & Compounds for RPS26 Gene

No Compound Related Data Available

Transcripts for RPS26 Gene

mRNA/cDNA for RPS26 Gene

Unigene Clusters for RPS26 Gene

Ribosomal protein S26:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPS26 Gene

No ASD Table

Relevant External Links for RPS26 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS26 Gene

mRNA expression in normal human tissues for RPS26 Gene

Protein differential expression in normal tissues from HIPED for RPS26 Gene

This gene is overexpressed in Pancreas (14.8) and Lung (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS26 Gene

SOURCE GeneReport for Unigene cluster for RPS26 Gene Hs.447562

genes like me logo Genes that share expression patterns with RPS26: view

Protein tissue co-expression partners for RPS26 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS26 Gene

Orthologs for RPS26 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS26 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPS26 35
  • 93.04 (n)
  • 100 (a)
RPS26 36
  • 74 (a)
(Canis familiaris)
Mammalia RPS26 35
  • 89.57 (n)
  • 100 (a)
RPS26 36
  • 85 (a)
(Mus musculus)
Mammalia Rps26 35
  • 86.09 (n)
  • 100 (a)
Rps26 16
Rps26 36
  • 100 (a)
Rps26-ps1 36
  • 100 (a)
(Pan troglodytes)
Mammalia RPS26 35
  • 99.71 (n)
  • 100 (a)
RPS26 36
  • 100 (a)
RPS26 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rps26 35
  • 87.54 (n)
  • 100 (a)
(Monodelphis domestica)
Mammalia RPS26 36
  • 80 (a)
(Gallus gallus)
Aves RPS26 35
  • 82.32 (n)
  • 98.26 (a)
RPS26 36
  • 69 (a)
(Anolis carolinensis)
Reptilia RPS26 36
  • 98 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rps26 35
  • 79.54 (n)
  • 98.02 (a)
Str.403 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.8381 35
(Danio rerio)
Actinopterygii -- 35
rps26l 35
  • 81.19 (n)
  • 99.01 (a)
rps26 36
  • 93 (a)
rps26l 36
  • 97 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpS26 37
  • 83 (a)
RpS26 35
  • 71.67 (n)
  • 86 (a)
RpS26 36
  • 77 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta RS26_ANOGA 35
  • 66.67 (n)
  • 83 (a)
(Caenorhabditis elegans)
Secernentea rps-26 35
  • 66.67 (n)
  • 79.21 (a)
rps-26 36
  • 74 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR194W 35
  • 63.67 (n)
  • 72 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D05115g 35
  • 63.04 (n)
  • 70.3 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS26B 35
  • 63.7 (n)
  • 72.28 (a)
RPS26A 36
  • 62 (a)
RPS26B 36
  • 62 (a)
RPS26A 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G40510 35
  • 62.71 (n)
  • 70.3 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04552 35
  • 69.33 (n)
  • 73 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps2602 35
  • 62.33 (n)
  • 72 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 57 (a)
Species with no ortholog for RPS26:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS26 Gene

Gene Tree for RPS26 (if available)
Gene Tree for RPS26 (if available)

Paralogs for RPS26 Gene

(1) SIMAP similar genes for RPS26 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RPS26: view

No data available for Paralogs for RPS26 Gene

Variants for RPS26 Gene

Sequence variations from dbSNP and Humsavar for RPS26 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_063580 Diamond-Blackfan anemia 10 (DBA10)
VAR_063581 Diamond-Blackfan anemia 10 (DBA10)
rs812822 -- 56,044,462(+) cctca(A/G)cttct downstream-variant-500B
rs111473859 -- 56,043,812(+) CTCTT(-/AAAA)AAAAA intron-variant
rs112803628 -- 56,044,253(+) CCAGA(C/T)AAGGT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RPS26 Gene

Variant ID Type Subtype PubMed ID
nsv832424 CNV Loss 17160897
nsv832427 CNV Loss 17160897

Variation tolerance for RPS26 Gene

Residual Variation Intolerance Score: 47.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 0.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS26 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS26 Gene

Disorders for RPS26 Gene

MalaCards: The human disease database

(8) MalaCards diseases for RPS26 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
diamond-blackfan anemia 10
  • dba10
rps26-related diamond-blackfan anemia
  • diamond-blackfan anemia 10
diamond blackfan anemia 15 with mandibulofacial dysostosis
  • diamond-blackfan anemia 15, with mandibulofacial dysostosis
diamond-blackfan anemia
  • blackfan - diamond syndrome
klippel-feil syndrome
  • autosomal dominant klippel-feil syndrome
- elite association - COSMIC cancer census association via MalaCards
Search RPS26 in MalaCards View complete list of genes associated with diseases


  • Diamond-Blackfan anemia 10 (DBA10) [MIM:613309]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. {ECO:0000269 PubMed:20116044}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for RPS26

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RPS26: view

No data available for Genatlas for RPS26 Gene

Publications for RPS26 Gene

  1. Isolation, structural analysis and mapping of the functional gene of human ribosomal protein S26. (PMID: 9602156) Filipenko M.L. … Amaldi F. (Gene 1998) 3 4 23 67
  2. [Mapping of the genes for ribosomal proteins S26, L19, and L32 on human chromosomes]. (PMID: 8670309) Filipenko M.L. … Mertvetsov N.P. (Bioorg. Khim. 1995) 2 3 23
  3. Human ribosomal protein S26 suppresses the splicing of its pre-mRNA. (PMID: 15716004) Ivanov A.V. … Karpova G.G. (Biochim. Biophys. Acta 2005) 3 23
  4. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3
  5. Cloning cDNA of human S26 ribosomal protein and determination of its primary structure. (PMID: 7945460) Filipenko M.L. … Mertvetsov N.P. (Bioorg. Khim. 1994) 3 23

Products for RPS26 Gene

Sources for RPS26 Gene