RPS26 Gene
protein-coding GIFtS: 59
GCID: GC12P056438
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|
ribosomal protein S26
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Aliases for RPS26 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Ribosomal Protein S261 2 | | S261 2 | | DBA102 5 | | 40S Ribosomal Protein S262 |
Export aliases for RPS26 gene to outside databasesPrevious GC identifers: GC13M099552 GC12P056999 GC12P056152 GC12P054721 GC12P054722 GC07P121716 |
Summaries for RPS26 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for RPS26: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This geneencodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S26E family ofribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there aremultiple processed pseudogenes of this gene dispersed through the genome. (provided by RefSeq, Jul 2008) Gene Wiki entry for RPS26
|
Genomic Views for RPS26 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the RPS26 gene promoter: GATA-3 MAZR FOXD1 STAT5A Nkx2-5 AP-2gamma AP-2beta AP-2alpha AP-2alphaA Other transcription factors
Search SABiosciences Chromatin IP Primers for RPS26
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS26 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13 Ensembl cytogenetic band: 12q13.2 HGNC cytogenetic band: 12q13RPS26 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P056438: view genomic region
(about GC identifiers)
Start:
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56,435,637 bp from pter |
End:
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56,438,116 bp from pter |
Size:
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2,480 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 121,716,059-121,716,492 |
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Proteins for RPS26 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: RS26_HUMAN, P62854 (See
protein sequence)Recommended Name: 40S ribosomal protein S26 Size: 115 amino acids; 13015 Da
Secondary accessions: P02383 P70394 Q06722 Q3MHD8 Q6IRY4Explore the universe of human proteins at neXtProt for RPS26: NX_P62854
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P62854 RPS26 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001020.2 ENSEMBL proteins: ENSP00000348849 ENSP00000450339 Reactome Protein details: P62854 Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
RPS26 for ontologies About GeneDecksing
RPS26 Antibody Products: Assay Products for RPS26: |
Protein
Domains / Families for RPS26 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RPS26 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P62854ProtoNet protein and cluster: P62854 UniProtKB/Swiss-Prot: RS26_HUMAN, P62854Similarity: Belongs to the ribosomal protein S26e family |
Function for RPS26 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: Genatlas biochemistry entry for RPS26:40S ribosomal protein S26,12kDa
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPS26 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPS26 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RPS26 (NM_001029) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPS26 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS26  |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
RPS26 for ontologies About GeneDecksing
9 GenomeRNAi human phenotypes for RPS26:
|
Pathways & Interactions for RPS26 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Synthesis of PB1-F2 | | | 2 | Translation initiation complex formation | | | 3 | Metabolism of mRNA | | | 4 | Disease | | | 5 | Generic Transcription Pathway | |
Pathway sources See GeneCards unified pathways Show all pathways
1 GeneGo (Thomson Reuters) Pathway for RPS26 1 BioSystems Pathway for RPS26 
5/32
Reactome Pathways for RPS26 (see all 32)
1
Kegg Pathway (Kegg details for RPS26):
RPS26 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPS26
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
 5/285 Interacting proteins for RPS26 (P628541, 2, 3 ENSP000003488494) via UniProtKB, MINT, STRING, and/or I2D (see all 285)About this table
Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
TAS | -- | | GO:0006412 | translation |
TAS | -- | | GO:0006413 | translational initiation |
TAS | -- | | GO:0006414 | translational elongation |
TAS | -- | | GO:0006415 | translational termination |
TAS | -- |
RPS26 for ontologies About GeneDecksing
|
Drugs & Compounds for RPS26 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for RPS26 Search CenterWatch for drugs/clinical trials and news about RPS26 / RS26 
|
Transcripts for RPS26 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for RPS26 gene: NM_001029.3 Unigene Clusters for RPS26: Ribosomal protein S26 Hs.447562 [show with all ESTs], Hs.567235 [show with all ESTs], Hs.711461 [show with all ESTs]Unigene Representative Sequences: HY000542, BG254525, BF2451993 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000356464(uc001sjf.3) ENST00000552361 ENST00000548590
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPS26 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPS26 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RPS26 (NM_001029) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPS26 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS26  |
Additional cDNA sequence: BC070220.1 BC105276.1 BC105798.1 24/40 DOTS entries (see all 40): DT.100045806 DT.100693259 DT.87017935 DT.99954821 DT.100845352 DT.95367132 DT.100845353 DT.120895400 DT.100045813 DT.121257972 DT.100845351 DT.121257901 DT.97862472 DT.100845348 DT.121308519 DT.121147930 DT.121147978 DT.91742026 DT.100845356 DT.101986392 DT.120895286 DT.120895608 DT.121014633 DT.121257992 24/86 AceView cDNA sequences (see all 86): BU623060 CR611958 BQ773828 AA360942 CA413381 BE394149 BM507057 BM800488 BX376032 BU930916 BU935543 BU928418 BM553510 BG500010 CB321972 BU602548 BU588092 BF794655 BG777482 W32999 BM792365 BV174302 BG110689 AA346106 GeneLoc Exon Structure
|
Expression for RPS26 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RPS26 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TAAGGAGCTG
About this image See RPS26 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for RPS26
SOURCE GeneReport for Unigene clusters: Hs.447562 Hs.567235 Hs.711461 SABiosciences Custom PCR Arrays for RPS26
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPS26 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RPS26 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS26 | |  | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS26 |
Orthologs for RPS26 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RPS26 gene from 10/30 species (see all 30) About this table
ENSEMBL Gene Tree for RPS26 (if available) TreeFam Gene Tree for RPS26 (if available)  |
Paralogs for RPS26 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for RPS26 gene
2 SIMAP similar genes for RPS26 using alignment to 2 protein entries: RS26_HUMAN (see all proteins):LOC100996747 RPS26P11
RPS26 for paralogs About GeneDecksing
5/41 Pseudogenes.org Pseudogenes for RPS26 (see all 41) PGOHUM00000238525 PGOHUM00000238643 PGOHUM00000238846 PGOHUM00000238874 PGOHUM00000242514
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Genomic Variants for RPS26 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 12 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for RPS26 (56435637 - 56438116 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for RPS26: -- Human Gene Mutation Database (HGMD): RPS26
 | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPS26 |
|
Disorders
/ Diseases for RPS26 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RPS26 for disorders About GeneDecksing
OMIM gene information: 603701 OMIM disorders: 613309 UniProtKB/Swiss-Prot: RS26_HUMAN, P62854
Defects in RPS26 are the cause of Diamond-Blackfan anemia type 10 (DBA10) [MIM:613309]. It is a form ofDiamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy.Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and anincreased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenitalanomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenitalanomalies 12 diseases for RPS26: About MalaCardsdiamond-blackfan anemia klippel-feil syndrome macrocytic anemia ureteral obstruction short stature fanconi's anemia anemia hepatocellular carcinoma prostate cancer prostatitis carcinoma malaria 2 diseases from the University of Copenhagen DISEASES database for RPS26:Diamond-Blackfan anemia Klippel-Feil syndrome Export disorders for RPS26 gene to outside databases
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Publications for RPS26 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RPS26 gene, integrated from 9 sources (see all 48): (articles sorted by number of sources associating them with RPS26) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Isolation, structural analysis and mapping of the functional gene of human ribosomal protein S26. (PubMed id 9602156)1, 2, 9 Filipenko M.L....Amaldi F. (1998)
- Cloning cDNA of human S26 ribosomal protein and determination of its primary structure. (PubMed id 7945460)1, 2, 9 Filipenko M.L....Mertvetsov N.P. (1994)
- [Mapping of the genes for ribosomal proteins S26, L19, and L32 on human chromosomes] (PubMed id 8670309)1, 3, 9 Filipenko M.L....Mertvetsov N.P. (1995)
- Ribosomal protein genes RPS10 and RPS26 are commonly mutated in Diamond-Blackfan anemia. (PubMed id 20116044)1, 2 Doherty L....Gazda H.T. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A map of 75 human ribosomal protein genes. (PubMed id 9582194)1, 3 Kenmochi N.... Page D.C. (1998)
- Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699)1, 2 Vladimirov S.N.... Otto A. (1996)
- S26 ribosomal protein RNA: an invariant control for gene regulation experiments in eucaryotic cells and tissues. (PubMed id 8464749)1, 2 Vincent S.... Fort P. (1993)
- Human ribosomal protein S26 suppresses the splicing of its pre-mRNA. (PubMed id 15716004)1, 9 Ivanov A.V....Karpova G.G. (2005)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
|
External Searches for RPS26 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RPS26 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RPS26 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RPS26 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for RPS26 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RPS26 gene: Search GeneIP for patents involving RPS26
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for RPS26 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for RPS26 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPS26 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPS26 | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for RPS26 | | OriGene 3'-UTR Clone for RPS26 | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPS26 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPS26 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RPS26 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPS26 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS26 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS26 | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS26 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS26 |
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 |  |  |  | |
| | | Search Tocris compounds for RPS26 |
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 | | RPS26 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | ThermoFisher Antibodies for RPS26 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS26 |
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