Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RPS26 Gene

Aliases for RPS26 Gene

  • Ribosomal Protein S26 2 3
  • 40S Ribosomal Protein S26 2 3
  • DBA10 3 6
  • S26 3

External Ids for RPS26 Gene

Previous GeneCards Identifiers for RPS26 Gene

  • GC13M099552
  • GC12P056999
  • GC12P056152
  • GC12P054721
  • GC12P054722
  • GC12P056438
  • GC07P121716

Summaries for RPS26 Gene

Entrez Gene Summary for RPS26 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S26E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS26 Gene

RPS26 (Ribosomal Protein S26) is a Protein Coding gene. Diseases associated with RPS26 include diamond-blackfan anemia 10 and rps26-related diamond-blackfan anemia. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include structural constituent of ribosome and mRNA binding.

Gene Wiki entry for RPS26 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS26 Gene

Genomics for RPS26 Gene

Regulatory Elements for RPS26 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RPS26 Gene

Start:
56,041,853 bp from pter
End:
56,044,675 bp from pter
Size:
2,823 bases
Orientation:
Plus strand

Genomic View for RPS26 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPS26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS26 Gene

Proteins for RPS26 Gene

  • Protein details for RPS26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62854-RS26_HUMAN
    Recommended name:
    40S ribosomal protein S26
    Protein Accession:
    P62854
    Secondary Accessions:
    • P02383
    • P70394
    • Q06722
    • Q3MHD8
    • Q6IRY4

    Protein attributes for RPS26 Gene

    Size:
    115 amino acids
    Molecular mass:
    13015 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS26 Gene

neXtProt entry for RPS26 Gene

Proteomics data for RPS26 Gene at MOPED

Post-translational modifications for RPS26 Gene

  • Ubiquitination at Lys66
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS26 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RPS26 Gene

Domains for RPS26 Gene

Gene Families for RPS26 Gene

HGNC:
  • RPS :S ribosomal proteins

Protein Domains for RPS26 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RPS26 Gene

Graphical View of Domain Structure for InterPro Entry

P62854

UniProtKB/Swiss-Prot:

RS26_HUMAN :
  • P62854
Family:
  • Belongs to the ribosomal protein S26e family.
genes like me logo Genes that share domains with RPS26: view

Function for RPS26 Gene

Molecular function for RPS26 Gene

GENATLAS Biochemistry: 40S ribosomal protein S26,12kDa

Gene Ontology (GO) - Molecular Function for RPS26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003729 mRNA binding IDA 15716004
GO:0003735 structural constituent of ribosome IEA --
GO:0005515 protein binding IPI 16189514
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPS26: view
genes like me logo Genes that share phenotypes with RPS26: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPS26

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPS26 Gene

Localization for RPS26 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS26 Gene COMPARTMENTS Subcellular localization image for RPS26 gene
Compartment Confidence
cytosol 5
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPS26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome --
genes like me logo Genes that share ontologies with RPS26: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS26 Gene

Pathways for RPS26 Gene

SuperPathways for RPS26 Gene

Superpath Contained pathways
1 Influenza Viral RNA Transcription and Replication
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 CFTR translational fidelity (class I mutations)
.54
4 Disease
5 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
genes like me logo Genes that share pathways with RPS26: view

Pathways by source for RPS26 Gene

1 KEGG pathway for RPS26 Gene
1 GeneGo (Thomson Reuters) pathway for RPS26 Gene

Gene Ontology (GO) - Biological Process for RPS26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
GO:0006415 translational termination TAS --
genes like me logo Genes that share ontologies with RPS26: view

Transcripts for RPS26 Gene

mRNA/cDNA for RPS26 Gene

Unigene Clusters for RPS26 Gene

Ribosomal protein S26:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPS26

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS26 Gene

No ASD Table

Relevant External Links for RPS26 Gene

GeneLoc Exon Structure for
RPS26
ECgene alternative splicing isoforms for
RPS26

Expression for RPS26 Gene

mRNA expression in normal human tissues for RPS26 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS26 Gene

SOURCE GeneReport for Unigene cluster for RPS26 Gene Hs.447562

genes like me logo Genes that share expressions with RPS26: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS26 Gene

Orthologs for RPS26 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPS26 35
  • 99.71 (n)
  • 100 (a)
RPS26 36
  • 100 (a)
OneToMany
RPS26 36
  • 100 (a)
OneToMany
cow
(Bos Taurus)
Mammalia RPS26 35
  • 93.04 (n)
  • 100 (a)
RPS26 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPS26 35
  • 89.57 (n)
  • 100 (a)
RPS26 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rps26 35
  • 86.09 (n)
  • 100 (a)
Rps26 16
Rps26 36
  • 100 (a)
OneToMany
Rps26-ps1 36
  • 100 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia RPS26 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rps26 35
  • 87.54 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves RPS26 35
  • 82.32 (n)
  • 98.26 (a)
RPS26 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPS26 36
  • 98 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8381 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rps26 35
  • 79.54 (n)
  • 98.02 (a)
Str.403 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
rps26 36
  • 93 (a)
OneToMany
rps26l 35
  • 81.19 (n)
  • 99.01 (a)
rps26l 36
  • 97 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta RS26_ANOGA 35
  • 66.67 (n)
  • 83 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpS26 35
  • 71.67 (n)
  • 86 (a)
RpS26 36
  • 77 (a)
OneToOne
RpS26 37
  • 83 (a)
worm
(Caenorhabditis elegans)
Secernentea rps-26 35
  • 66.67 (n)
  • 79.21 (a)
rps-26 36
  • 74 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR194W 35
  • 63.67 (n)
  • 72 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS26A 36
  • 62 (a)
OneToMany
RPS26A 38
RPS26B 35
  • 63.7 (n)
  • 72.28 (a)
RPS26B 36
  • 62 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D05115g 35
  • 63.04 (n)
  • 70.3 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G40510 35
  • 62.71 (n)
  • 70.3 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04552 35
  • 69.33 (n)
  • 73 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps2602 35
  • 62.33 (n)
  • 72 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 57 (a)
OneToOne
Species with no ortholog for RPS26:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS26 Gene

ENSEMBL:
Gene Tree for RPS26 (if available)
TreeFam:
Gene Tree for RPS26 (if available)

Paralogs for RPS26 Gene

Selected SIMAP similar genes for RPS26 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RPS26: view

No data available for Paralogs for RPS26 Gene

Variants for RPS26 Gene

Sequence variations from dbSNP and Humsavar for RPS26 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs705704 -- 56,041,628(+) ACCTA(A/G)TAGAA upstream-variant-2KB
rs705705 -- 56,041,720(+) GGGGG(C/G)GAGGG upstream-variant-2KB
rs705706 -- 56,042,688(+) TGTTC(G/T)TTGGA intron-variant
rs705707 -- 56,042,826(-) GCAAA(C/G)CTTTA intron-variant
rs773106 -- 56,039,999(-) atctc(C/T)tgacc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPS26 Gene

Variant ID Type Subtype PubMed ID
nsv832424 CNV Loss 17160897
nsv832427 CNV Loss 17160897

Relevant External Links for RPS26 Gene

HapMap Linkage Disequilibrium report
RPS26
Human Gene Mutation Database (HGMD)
RPS26

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS26 Gene

Disorders for RPS26 Gene

(1) OMIM Diseases for RPS26 Gene (603701)

UniProtKB/Swiss-Prot

RS26_HUMAN
  • Diamond-Blackfan anemia 10 (DBA10) [MIM:613309]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. {ECO:0000269 PubMed:20116044}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for RPS26 Gene

Relevant External Links for RPS26

Genetic Association Database (GAD)
RPS26
genes like me logo Genes that share disorders with RPS26: view

Publications for RPS26 Gene

  1. [Mapping of the genes for ribosomal proteins S26, L19, and L32 on human chromosomes]. (PMID: 8670309) Filipenko M.L. … Mertvetsov N.P. (Bioorg. Khim. 1995) 2 3 23
  2. Isolation, structural analysis and mapping of the functional gene of human ribosomal protein S26. (PMID: 9602156) Filipenko M.L. … Amaldi F. (Gene 1998) 3 4 23
  3. Cloning cDNA of human S26 ribosomal protein and determination of its primary structure. (PMID: 7945460) Filipenko M.L. … Mertvetsov N.P. (Bioorg. Khim. 1994) 3 4 23
  4. Ribosomal protein genes RPS10 and RPS26 are commonly mutated in Diamond-Blackfan anemia. (PMID: 20116044) Doherty L. … Gazda H.T. (Am. J. Hum. Genet. 2010) 3 4
  5. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3

Products for RPS26 Gene

Sources for RPS26 Gene

Back to Top

Content