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Aliases for RPS25 Gene

Aliases for RPS25 Gene

  • Ribosomal Protein S25 2 3 5
  • S25 3

External Ids for RPS25 Gene

Previous GeneCards Identifiers for RPS25 Gene

  • GC11M134077
  • GC11M120398
  • GC11M118917
  • GC11M118424
  • GC11M118391
  • GC11M114826
  • GC11M118886

Summaries for RPS25 Gene

Entrez Gene Summary for RPS25 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S25E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS25 Gene

RPS25 (Ribosomal Protein S25) is a Protein Coding gene. Among its related pathways are Gene Expression and Metabolism. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPS25 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS25 Gene

Genomics for RPS25 Gene

Regulatory Elements for RPS25 Gene

Promoters for RPS25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPS25 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPS25 Gene

Chromosome:
11
Start:
119,015,712 bp from pter
End:
119,018,691 bp from pter
Size:
2,980 bases
Orientation:
Minus strand

Genomic View for RPS25 Gene

Genes around RPS25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS25 Gene

Proteins for RPS25 Gene

  • Protein details for RPS25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62851-RS25_HUMAN
    Recommended name:
    40S ribosomal protein S25
    Protein Accession:
    P62851
    Secondary Accessions:
    • B2R4M7
    • P25111

    Protein attributes for RPS25 Gene

    Size:
    125 amino acids
    Molecular mass:
    13742 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS25 Gene

neXtProt entry for RPS25 Gene

Proteomics data for RPS25 Gene at MOPED

Post-translational modifications for RPS25 Gene

  • Ubiquitination at Lys 43, Lys 52, Lys 60, Lys 94, Lys 98, and Lys 114
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS25 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RPS25 Gene

Domains & Families for RPS25 Gene

Gene Families for RPS25 Gene

Protein Domains for RPS25 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RPS25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62851

UniProtKB/Swiss-Prot:

RS25_HUMAN :
  • Belongs to the ribosomal protein S25e family.
Family:
  • Belongs to the ribosomal protein S25e family.
genes like me logo Genes that share domains with RPS25: view

Function for RPS25 Gene

Molecular function for RPS25 Gene

GENATLAS Biochemistry:
40S ribosomal protein S25,13kDa

Gene Ontology (GO) - Molecular Function for RPS25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22720776
genes like me logo Genes that share ontologies with RPS25: view
genes like me logo Genes that share phenotypes with RPS25: view

Animal Model Products

miRNA for RPS25 Gene

miRTarBase miRNAs that target RPS25

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS25 Gene

Localization for RPS25 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS25 Gene COMPARTMENTS Subcellular localization image for RPS25 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5

Gene Ontology (GO) - Cellular Components for RPS25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome NAS 8020948
GO:0015935 small ribosomal subunit IDA 15883184
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with RPS25: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS25 Gene

Pathways & Interactions for RPS25 Gene

SuperPathways for RPS25 Gene

Superpath Contained pathways
1 Viral mRNA Translation
.60
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 Infectious disease
.48
5 rRNA processing
genes like me logo Genes that share pathways with RPS25: view

Pathways by source for RPS25 Gene

1 BioSystems pathway for RPS25 Gene
1 KEGG pathway for RPS25 Gene
1 GeneGo (Thomson Reuters) pathway for RPS25 Gene

Gene Ontology (GO) - Biological Process for RPS25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006413 translational initiation TAS --
GO:0006415 translational termination TAS --
GO:0016032 viral process TAS --
genes like me logo Genes that share ontologies with RPS25: view

No data available for SIGNOR curated interactions for RPS25 Gene

Drugs & Compounds for RPS25 Gene

No Compound Related Data Available

Transcripts for RPS25 Gene

Unigene Clusters for RPS25 Gene

Ribosomal protein S25:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPS25 Gene

No ASD Table

Relevant External Links for RPS25 Gene

GeneLoc Exon Structure for
RPS25
ECgene alternative splicing isoforms for
RPS25

Expression for RPS25 Gene

mRNA expression in normal human tissues for RPS25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPS25 Gene

This gene is overexpressed in Nasal epithelium (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS25 Gene



SOURCE GeneReport for Unigene cluster for RPS25 Gene Hs.512676

genes like me logo Genes that share expression patterns with RPS25: view

Protein tissue co-expression partners for RPS25 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS25 Gene

Orthologs for RPS25 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPS25 35
  • 100 (n)
  • 100 (a)
RPS25 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 80 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
RPS25 36
  • 100 (a)
OneToMany
RPS25 36
  • 100 (a)
OneToMany
RPS25 35
  • 93.6 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia RPS25 35
  • 92.8 (n)
  • 100 (a)
RPS25 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rps25 16
Rps25 36
  • 100 (a)
OneToOne
Rps25 35
  • 88.53 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia RPS25 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPS25 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rps25 35
  • 91.47 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves RPS25 36
  • 99 (a)
OneToOne
RPS25 35
  • 82.13 (n)
  • 99.2 (a)
lizard
(Anolis carolinensis)
Reptilia RPS25 36
  • 98 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.787 35
zebrafish
(Danio rerio)
Actinopterygii rps25 35
  • 78.82 (n)
  • 91.59 (a)
zgc73391 35
rps25 36
  • 85 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004462 35
  • 69.8 (n)
  • 82.35 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpS25 36
  • 69 (a)
OneToOne
RpS25 35
  • 69.77 (n)
  • 79.07 (a)
worm
(Caenorhabditis elegans)
Secernentea rps-25 36
  • 66 (a)
OneToOne
rps-25 35
  • 65.1 (n)
  • 72.94 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS25A 36
  • 45 (a)
OneToMany
RPS25B 36
  • 44 (a)
OneToMany
corn
(Zea mays)
Liliopsida Zm.12378 35
rice
(Oryza sativa)
Liliopsida Os.22978 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 72 (a)
OneToOne
Species with no ortholog for RPS25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RPS25 Gene

ENSEMBL:
Gene Tree for RPS25 (if available)
TreeFam:
Gene Tree for RPS25 (if available)

Paralogs for RPS25 Gene

genes like me logo Genes that share paralogs with RPS25: view

No data available for Paralogs for RPS25 Gene

Variants for RPS25 Gene

Sequence variations from dbSNP and Humsavar for RPS25 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs111446537 -- 119,016,365(+) GGAGA(C/G)CAGCC intron-variant
rs147336503 -- 119,016,510(+) TAGAA(A/G)TACAA intron-variant
rs187427495 -- 119,016,474(+) CTCAA(A/T)TGATC intron-variant
rs369407946 -- 119,016,440(+) CAGAG(G/T)TGCCC intron-variant
rs533630277 -- 119,016,347(+) GTGGA(G/T)CTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPS25 Gene

Variant ID Type Subtype PubMed ID
nsv826101 CNV Gain 20364138

Variation tolerance for RPS25 Gene

Residual Variation Intolerance Score: 46.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 1.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS25 Gene

HapMap Linkage Disequilibrium report
RPS25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS25 Gene

Disorders for RPS25 Gene

Relevant External Links for RPS25

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPS25

No disorders were found for RPS25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPS25 Gene

Publications for RPS25 Gene

  1. Cloning and sequencing a cDNA encoding human ribosomal protein S25. (PMID: 1748303) Li M. … Center M.S. (Gene 1991) 2 3 4 23 67
  2. Nuclear and nucleolar targeting of human ribosomal protein S25: common features shared with HIV-1 regulatory proteins. (PMID: 10050887) Kubota S. … Pomerantz R.J. (Oncogene 1999) 3 23
  3. Assignment of the human ribosomal protein S25 gene (RPS25) to chromosome 11q23.3 by sequence analysis of the marker D11S456. (PMID: 8020948) Imai T. … Miwa T. (Genomics 1994) 3 23
  4. Regulation of ribosomal protein S25 in HL60 cells isolated for resistance to adriamycin. (PMID: 1544436) Li M. … Center M.S. (FEBS Lett. 1992) 3 23
  5. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3

Products for RPS25 Gene

Sources for RPS25 Gene

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