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Aliases for RPS25 Gene

Aliases for RPS25 Gene

  • Ribosomal Protein S25 2 3 5
  • Small Ribosomal Subunit Protein ES25 3 4
  • 40S Ribosomal Protein S25 3
  • S25 3

External Ids for RPS25 Gene

Previous GeneCards Identifiers for RPS25 Gene

  • GC11M134077
  • GC11M120398
  • GC11M118917
  • GC11M118424
  • GC11M118391
  • GC11M114826
  • GC11M118886

Summaries for RPS25 Gene

Entrez Gene Summary for RPS25 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S25E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS25 Gene

RPS25 (Ribosomal Protein S25) is a Protein Coding gene. Diseases associated with RPS25 include Spherocytosis, Type 4. Among its related pathways are Viral mRNA Translation and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPS25 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS25 Gene

Genomics for RPS25 Gene

Regulatory Elements for RPS25 Gene

Enhancers for RPS25 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G119090 1.7 Ensembl ENCODE dbSUPER 13.5 -75.0 -74981 5.9 CREB3L1 AGO1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 HINFP ARCN1 RNF26 ENSG00000254909 C2CD2L BCL9L RPL23AP64 UBE4A RPS25 IFT46
GH11G119167 1.1 ENCODE 13.4 -150.2 -150238 2.8 PKNOX1 ARNT WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF302 BCL9L IFT46 ENSG00000254909 UBE4A RPL23AP64 ARCN1 HINFP DDX6 ENSG00000254428 ENSG00000272186
GH11G119065 0.8 ENCODE 12.3 -46.9 -46914 0.2 BCOR HDAC1 CTCF RB1 WRNIP1 JUN ZMYM3 ZNF48 RAD21 ZNF766 H2AFX C2CD2L DPAGT1 SLC37A4 RPS25 TRAPPC4 HINFP NLRX1 FOXR1 ENSG00000222529
GH11G119062 0.8 ENCODE 12.3 -44.3 -44304 0.1 BCOR HDAC1 FOSL1 GTF3C2 ZNF316 ADNP NFE2 RCOR1 MAFK NFE2L2 ENSG00000254909 ENSG00000254428 RPL23AP64 UBE4A HMBS H2AFX C2CD2L DPAGT1 SLC37A4 RPS25
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPS25 on UCSC Golden Path with GeneCards custom track

Promoters for RPS25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for RPS25 Gene

119,015,712 bp from pter
119,018,691 bp from pter
2,980 bases
Minus strand

Genomic View for RPS25 Gene

Genes around RPS25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS25 Gene

Proteins for RPS25 Gene

  • Protein details for RPS25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    40S ribosomal protein S25
    Protein Accession:
    Secondary Accessions:
    • B2R4M7
    • P25111

    Protein attributes for RPS25 Gene

    125 amino acids
    Molecular mass:
    13742 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS25 Gene

neXtProt entry for RPS25 Gene

Post-translational modifications for RPS25 Gene

  • Ubiquitination at isoforms=43, isoforms=52, isoforms=60, Lys94, isoforms=98, and isoforms=1114
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS25 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPS25 Gene

Domains & Families for RPS25 Gene

Gene Families for RPS25 Gene

Protein Domains for RPS25 Gene


Suggested Antigen Peptide Sequences for RPS25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eukaryotic ribosomal protein eS25 family.
  • Belongs to the eukaryotic ribosomal protein eS25 family.
genes like me logo Genes that share domains with RPS25: view

Function for RPS25 Gene

Molecular function for RPS25 Gene

GENATLAS Biochemistry:
40S ribosomal protein S25,13kDa

Gene Ontology (GO) - Molecular Function for RPS25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding NAS 10050887
GO:0005515 protein binding IPI 22720776
genes like me logo Genes that share ontologies with RPS25: view
genes like me logo Genes that share phenotypes with RPS25: view

Animal Model Products

miRNA for RPS25 Gene

miRTarBase miRNAs that target RPS25

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS25 Gene

Localization for RPS25 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS25 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for RPS25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA 10050887
GO:0005829 cytosol TAS --
GO:0005840 ribosome NAS 8020948
genes like me logo Genes that share ontologies with RPS25: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS25 Gene

Pathways & Interactions for RPS25 Gene

SuperPathways for RPS25 Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing in the nucleus and cytosol
5 HIV Life Cycle
genes like me logo Genes that share pathways with RPS25: view

Gene Ontology (GO) - Biological Process for RPS25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation NAS 8020948
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPS25: view

No data available for SIGNOR curated interactions for RPS25 Gene

Drugs & Compounds for RPS25 Gene

No Compound Related Data Available

Transcripts for RPS25 Gene

Unigene Clusters for RPS25 Gene

Ribosomal protein S25:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS25 Gene

No ASD Table

Relevant External Links for RPS25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPS25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPS25 Gene

This gene is overexpressed in Nasal epithelium (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPS25 Gene

Protein tissue co-expression partners for RPS25 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS25 Gene:


SOURCE GeneReport for Unigene cluster for RPS25 Gene:


Evidence on tissue expression from TISSUES for RPS25 Gene

  • Skin(4.8)
  • Pancreas(4.6)
  • Muscle(4.5)
  • Lung(4.4)
  • Nervous system(4.2)
  • Liver(4.1)
  • Eye(4)
  • Heart(4)
  • Intestine(3.5)
  • Bone(2.8)
  • Blood(2.7)
  • Stomach(2.7)
  • Thyroid gland(2.7)
  • Lymph node(2.6)
  • Bone marrow(2.5)
  • Spleen(2.5)
  • Adrenal gland(2.4)
  • Gall bladder(2.3)
  • Kidney(2.3)
genes like me logo Genes that share expression patterns with RPS25: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS25 Gene

Orthologs for RPS25 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS25 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPS25 34 35
  • 100 (n)
(Ornithorhynchus anatinus)
Mammalia RPS25 35
  • 98 (a)
(Monodelphis domestica)
Mammalia RPS25 35
  • 96 (a)
(Bos Taurus)
Mammalia RPS25 34 35 35
  • 93.6 (n)
-- 35
  • 80 (a)
-- 35
  • 76 (a)
(Canis familiaris)
Mammalia RPS25 34 35
  • 92.8 (n)
(Rattus norvegicus)
Mammalia Rps25 34
  • 91.47 (n)
(Mus musculus)
Mammalia Rps25 34 16 35
  • 88.53 (n)
(Gallus gallus)
Aves RPS25 34 35
  • 82.13 (n)
(Anolis carolinensis)
Reptilia RPS25 35
  • 98 (a)
(Danio rerio)
Actinopterygii rps25 34 35
  • 78.82 (n)
zgc73391 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.787 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004462 34
  • 69.8 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpS25 34 35
  • 69.77 (n)
(Caenorhabditis elegans)
Secernentea rps-25 34 35
  • 65.1 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS25A 35
  • 45 (a)
RPS25B 35
  • 44 (a)
(Oryza sativa)
Liliopsida Os.22978 34
(Zea mays)
Liliopsida Zm.12378 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 72 (a)
Species where no ortholog for RPS25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RPS25 Gene

Gene Tree for RPS25 (if available)
Gene Tree for RPS25 (if available)

Paralogs for RPS25 Gene

No data available for Paralogs for RPS25 Gene

Variants for RPS25 Gene

Sequence variations from dbSNP and Humsavar for RPS25 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs386352288 Uncertain significance 119,015,316(+) AAAAC(A/G)GAAGT nc-transcript-variant, downstream-variant-500B, reference, missense
rs1000121364 -- 119,015,770(+) AAAAA(A/G)ATTAA intron-variant, nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1000708180 -- 119,019,907(+) CACAT(A/G)TTCCT intron-variant, upstream-variant-2KB
rs1000730956 -- 119,017,219(+) AAGAC(A/G)TCAGA intron-variant, upstream-variant-2KB
rs1001022384 -- 119,018,706(+) GCTGG(G/T)GTGGG upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for RPS25 Gene

Variant ID Type Subtype PubMed ID
nsv826101 CNV gain 20364138
nsv983067 CNV duplication 23825009

Variation tolerance for RPS25 Gene

Residual Variation Intolerance Score: 46.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 1.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS25 Gene

Disorders for RPS25 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPS25 Gene - From: DISEASES

Disorder Aliases PubMed IDs
spherocytosis, type 4
  • hereditary spherocytosis type 4
- elite association - COSMIC cancer census association via MalaCards
Search RPS25 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RPS25

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RPS25: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS25 Gene

Publications for RPS25 Gene

  1. Cloning and sequencing a cDNA encoding human ribosomal protein S25. (PMID: 1748303) Li M. … Center M.S. (Gene 1991) 2 3 4 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PMID: 11875025) Yoshihama M. … Kenmochi N. (Genome Res. 2002) 3 4 64
  4. Nuclear and nucleolar targeting of human ribosomal protein S25: common features shared with HIV-1 regulatory proteins. (PMID: 10050887) Kubota S. … Pomerantz R.J. (Oncogene 1999) 3 22 64
  5. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PMID: 8706699) Vladimirov S.N. … Otto A. (Eur. J. Biochem. 1996) 3 4 64

Products for RPS25 Gene

Sources for RPS25 Gene

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