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Aliases for RPS24 Gene

Aliases for RPS24 Gene

  • Ribosomal Protein S24 2 3
  • DBA3 3 6
  • 40S Ribosomal Protein S24 3
  • S24 3

External Ids for RPS24 Gene

Summaries for RPS24 Gene

Entrez Gene Summary for RPS24 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S24E family of ribosomal proteins. It is located in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Mutations in this gene result in Diamond-Blackfan anemia. [provided by RefSeq, Nov 2008]

GeneCards Summary for RPS24 Gene

RPS24 (Ribosomal Protein S24) is a Protein Coding gene. Diseases associated with RPS24 include diamond-blackfan anemia 3 and diamond-blackfan anemia. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include nucleotide binding and translation initiation factor binding.

UniProtKB/Swiss-Prot for RPS24 Gene

  • Required for processing of pre-rRNA and maturation of 40S ribosomal subunits.

Gene Wiki entry for RPS24 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS24 Gene

Genomics for RPS24 Gene

Genomic Location for RPS24 Gene

Start:
78,033,760 bp from pter
End:
78,056,813 bp from pter
Size:
23,054 bases
Orientation:
Plus strand

Genomic View for RPS24 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPS24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS24 Gene

Regulatory Elements for RPS24 Gene

Proteins for RPS24 Gene

  • Protein details for RPS24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62847-RS24_HUMAN
    Recommended name:
    40S ribosomal protein S24
    Protein Accession:
    P62847
    Secondary Accessions:
    • E7EPK6
    • P16632
    • Q5T0P7
    • Q5T0P8
    • Q7Z3D1

    Protein attributes for RPS24 Gene

    Size:
    133 amino acids
    Molecular mass:
    15423 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS24 Gene

    Alternative splice isoforms for RPS24 Gene

neXtProt entry for RPS24 Gene

Proteomics data for RPS24 Gene at MOPED

Post-translational modifications for RPS24 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys21, Lys32, Lys37, Lys49, Lys68, and Lys83

Other Protein References for RPS24 Gene

No data available for DME Specific Peptides for RPS24 Gene

Domains for RPS24 Gene

Gene Families for RPS24 Gene

HGNC:
  • RPS :S ribosomal proteins

UniProtKB/Swiss-Prot:

RS24_HUMAN
Family:
  • Belongs to the ribosomal protein S24e family.:
    • P62847
genes like me logo Genes that share domains with RPS24: view

Function for RPS24 Gene

Molecular function for RPS24 Gene

GENATLAS Biochemistry: 40S ribosomal protein S24,small subunit,5kDa
UniProtKB/Swiss-Prot Function: Required for processing of pre-rRNA and maturation of 40S ribosomal subunits.

Gene Ontology (GO) - Molecular Function for RPS24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003735 structural constituent of ribosome NAS 18412286
GO:0031369 translation initiation factor binding ISS --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPS24: view
genes like me logo Genes that share phenotypes with RPS24: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPS24 Gene

Localization for RPS24 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS24 Gene COMPARTMENTS Subcellular localization image for RPS24 gene
Compartment Confidence
cytosol 5
nucleus 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for RPS24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IBA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RPS24: view

Pathways for RPS24 Gene

SuperPathways for RPS24 Gene

Superpath Contained pathways
1 Influenza Viral RNA Transcription and Replication
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 CFTR translational fidelity (class I mutations)
.54
4 Disease
5 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
genes like me logo Genes that share pathways with RPS24: view

Pathways by source for RPS24 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for RPS24 Gene
1 BioSystems pathway for RPS24 Gene

Gene Ontology (GO) - Biological Process for RPS24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0006364 rRNA processing IMP 18230666
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPS24: view

Transcripts for RPS24 Gene

Unigene Clusters for RPS24 Gene

Ribosomal protein S24:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPS24 Gene

No ASD Table

Relevant External Links for RPS24 Gene

GeneLoc Exon Structure for
RPS24
ECgene alternative splicing isoforms for
RPS24

Expression for RPS24 Gene

mRNA expression in normal human tissues for RPS24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS24 Gene

SOURCE GeneReport for Unigene cluster for RPS24 Gene Hs.280130

mRNA Expression by UniProt/SwissProt for RPS24 Gene

P62847-RS24_HUMAN
Tissue specificity: Mature tissues, such as adult brain, skeletal muscle, heart, and kidney, express low levels, whereas tissues and organs with significant populations of proliferating cells, such as fetal brain, placenta, bone marrow, and various glandular organs, contain significantly higher levels.
genes like me logo Genes that share expressions with RPS24: view

Orthologs for RPS24 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPS24 36
  • 99.24 (n)
  • 100 (a)
RPS24 37
  • 83 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RPS24 36
  • 92.05 (n)
  • 100 (a)
RPS24 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 91 (a)
OneToMany
-- 37
  • 93 (a)
OneToMany
-- 37
  • 83 (a)
OneToMany
-- 37
  • 88 (a)
OneToMany
-- 37
  • 92 (a)
OneToMany
RPS24 36
  • 93.43 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Rps24 36
  • 88.89 (n)
  • 99.24 (a)
Rps24 16
Rps24 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RPS24 37
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPS24 37
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rps24 36
  • 88.64 (n)
  • 99.24 (a)
chicken
(Gallus gallus)
Aves RPS24 36
  • 84.85 (n)
  • 99.24 (a)
RPS24 37
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPS24 37
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rps24 36
  • 81.17 (n)
  • 100 (a)
zebrafish
(Danio rerio)
Actinopterygii rps24 36
  • 78.37 (n)
  • 90.08 (a)
rps24 37
  • 74 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005131 36
  • 65.63 (n)
  • 78.29 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpS24 36
  • 68.77 (n)
  • 77.95 (a)
RpS24 37
  • 63 (a)
OneToOne
CG3751 38
  • 77 (a)
worm
(Caenorhabditis elegans)
Secernentea rps-24 36
  • 61.79 (n)
  • 66.92 (a)
rps-24 37
  • 56 (a)
OneToOne
rps-24 38
  • 62 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL043W 36
  • 62.02 (n)
  • 63.93 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS24A 36
  • 63.93 (n)
  • 61.48 (a)
RPS24A 37
  • 46 (a)
OneToMany
RPS24A 39
RPS24B 37
  • 46 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C07755g 36
  • 62.33 (n)
  • 60.98 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2466 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G04920 36
  • 67.45 (n)
  • 67.19 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.3058 36
rice
(Oryza sativa)
Liliopsida Os02g0229000 36
  • 59.9 (n)
  • 67.19 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07182 36
  • 60.81 (n)
  • 58.02 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps2402 36
  • 63.66 (n)
  • 65.57 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11310 37
  • 64 (a)
OneToOne
Species with no ortholog for RPS24:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS24 Gene

ENSEMBL:
Gene Tree for RPS24 (if available)
TreeFam:
Gene Tree for RPS24 (if available)

Paralogs for RPS24 Gene

genes like me logo Genes that share paralogs with RPS24: view

No data available for Paralogs for RPS24 Gene

Variants for RPS24 Gene

Sequence variations from dbSNP and Humsavar for RPS24 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs6496 -- 78,035,618(+) TTTGG(A/G)TTCAG reference, synonymous-codon, nc-transcript-variant
rs13342 -- 78,040,626(+) GAGTA(A/T)AGGTG reference, stop-lost, utr-variant-3-prime, intron-variant, nc-transcript-variant
rs731776 -- 78,037,092(-) CACAG(C/T)TTTCT intron-variant
rs1863899 -- 78,045,145(-) CCAGG(C/T)ATGGT intron-variant
rs1863900 -- 78,042,492(-) CTTCC(C/T)GACAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPS24 Gene

Variant ID Type Subtype PubMed ID
nsv895736 CNV Gain 21882294
esv2676466 CNV Deletion 23128226

Relevant External Links for RPS24 Gene

HapMap Linkage Disequilibrium report
RPS24
Human Gene Mutation Database (HGMD)
RPS24
Locus Specific Mutation Databases (LSDB)
RPS24

Disorders for RPS24 Gene

(1) OMIM Diseases for RPS24 Gene (602412)

UniProtKB/Swiss-Prot

RS24_HUMAN
  • Diamond-Blackfan anemia 3 (DBA3) [MIM:610629]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of developing leukemia. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. {ECO:0000269 PubMed:17186470}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for RPS24 Gene

Relevant External Links for RPS24

GeneTests
RPS24
GeneReviews
RPS24
Genetic Association Database (GAD)
RPS24
Human Genome Epidemiology (HuGE) Navigator
RPS24
genes like me logo Genes that share disorders with RPS24: view

Publications for RPS24 Gene

  1. A cDNA encoding human ribosomal protein S24. (PMID: 2210388) Brown S.J. … Roufa D.J. (Gene 1990) 3 4 23
  2. The gene encoding human ribosomal protein S24 and tissue-specific expression of differentially spliced mRNAs. (PMID: 8647458) Xu W.-B. … Roufa D.J. (Gene 1996) 3 4 23
  3. Ribosomal protein S24 gene is mutated in Diamond-Blackfan anemia. (PMID: 17186470) Gazda H.T. … Sieff C.A. (Am. J. Hum. Genet. 2006) 3 4 23
  4. Ribosomal protein S19 and S24 insufficiency cause distinct cell cycle defects in Diamond-Blackfan anemia. (PMID: 19689926) Badhai J. … Dahl N. (Biochim. Biophys. Acta 2009) 3 23
  5. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PMID: 8706699) Vladimirov S.N. … Otto A. (Eur. J. Biochem. 1996) 3 4

Products for RPS24 Gene

Sources for RPS24 Gene

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