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Aliases for RPS23 Gene

Aliases for RPS23 Gene

  • Ribosomal Protein S23 2 3 5
  • Small Ribosomal Subunit Protein US12 3 4
  • Homolog Of Yeast Ribosomal Protein S28 3
  • 40S Ribosomal Protein S23 3
  • MABAS 3
  • MCINS 3
  • PAMAS 3
  • BTDD 3
  • S23 3

External Ids for RPS23 Gene

Previous GeneCards Identifiers for RPS23 Gene

  • GC05M080389
  • GC05M081796
  • GC05M081608
  • GC05M081655
  • GC05M081607
  • GC05M076778
  • GC05M081569

Summaries for RPS23 Gene

Entrez Gene Summary for RPS23 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S12P family of ribosomal proteins. It is located in the cytoplasm. The protein shares significant amino acid similarity with S. cerevisiae ribosomal protein S28. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS23 Gene

RPS23 (Ribosomal Protein S23) is a Protein Coding gene. Diseases associated with RPS23 include Brachycephaly, Trichomegaly, And Developmental Delay and Retinitis Pigmentosa 20. Among its related pathways are Viral mRNA Translation and Metabolism. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPS23 Gene

Additional gene information for RPS23 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS23 Gene

Genomics for RPS23 Gene

Regulatory Elements for RPS23 Gene

Enhancers for RPS23 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H082386 1.6 Ensembl ENCODE dbSUPER 11.7 -109.4 -109424 3.8 PKNOX1 FOXA2 MLX FEZF1 YY1 ZNF302 FOS SP5 MXD4 REST ATP6AP1L RPS23 ATG10 PIR35354 GC05P082524 GC05P082523
GH05H081748 1.4 ENCODE dbSUPER 11.6 +528.0 528038 4.5 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 YY1 ZNF766 CBX5 ZNF207 ZCCHC9 CKMT2-AS1 RPS23 ATG10 SSBP2 GC05M081517
GH05H081970 1.1 ENCODE 14.4 +306.8 306801 2.8 HDGF FOXA2 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 ZNF143 ATG10 ATP6AP1L RPS23 SEM1P1
GH05H083095 1.3 Ensembl ENCODE 11.6 -818.6 -818606 3.8 PKNOX1 ZNF133 FEZF1 GLI4 ZNF2 GLIS2 ZNF302 ATF7 KLF7 FOS XRCC4 ATP6AP1L VCAN-AS1 RPL13AP14 RPS23 SCARNA18 LOC105379052 TMEM167A RPL13P9
GH05H082404 1.8 FANTOM5 Ensembl ENCODE dbSUPER 8.3 -127.2 -127245 3.3 PKNOX1 ARNT ZNF133 FEZF1 ZNF2 ZNF121 GLIS2 FOS KLF7 TSHZ1 ATG10 RPS23 ATP6AP1L LOC105379052 PIR35354 GC05P082523 GC05P082524
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPS23 on UCSC Golden Path with GeneCards custom track

Promoters for RPS23 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000183307 277 2201 ARNT ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 PAF1 SP3 SP5

Genomic Locations for RPS23 Gene

Genomic Locations for RPS23 Gene
5,258 bases
Minus strand

Genomic View for RPS23 Gene

Genes around RPS23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS23 Gene

Proteins for RPS23 Gene

  • Protein details for RPS23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    40S ribosomal protein S23
    Protein Accession:
    Secondary Accessions:
    • P39028
    • Q6IB08

    Protein attributes for RPS23 Gene

    143 amino acids
    Molecular mass:
    15808 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS23 Gene

neXtProt entry for RPS23 Gene

Post-translational modifications for RPS23 Gene

  • Hydroxylation at Pro-62 affects translation termination efficiency.
  • Ubiquitination at isoforms=37, Lys48, and isoforms=54
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS23 Gene

No data available for DME Specific Peptides for RPS23 Gene

Domains & Families for RPS23 Gene

Gene Families for RPS23 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPS23 Gene

Suggested Antigen Peptide Sequences for RPS23 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the universal ribosomal protein uS12 family.
  • Belongs to the universal ribosomal protein uS12 family.
genes like me logo Genes that share domains with RPS23: view

Function for RPS23 Gene

Molecular function for RPS23 Gene

GENATLAS Biochemistry:
60S ribosomal protein S23

Gene Ontology (GO) - Molecular Function for RPS23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22681889
GO:0003735 structural constituent of ribosome IBA,IEA --
GO:0005515 protein binding IPI 20434207
genes like me logo Genes that share ontologies with RPS23: view
genes like me logo Genes that share phenotypes with RPS23: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS23 Gene

Localization for RPS23 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS23 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Endoplasmic reticulum (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPS23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0005840 ribosome NAS,IEA 8415000
GO:0015935 small ribosomal subunit IEA --
genes like me logo Genes that share ontologies with RPS23: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS23 Gene

Pathways & Interactions for RPS23 Gene

SuperPathways for RPS23 Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing in the nucleus and cytosol
5 HIV Life Cycle
genes like me logo Genes that share pathways with RPS23: view

Gene Ontology (GO) - Biological Process for RPS23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,IMP 28257692
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPS23: view

No data available for SIGNOR curated interactions for RPS23 Gene

Drugs & Compounds for RPS23 Gene

No Compound Related Data Available

Transcripts for RPS23 Gene

Unigene Clusters for RPS23 Gene

Ribosomal protein S23:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS23 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7
SP1: - - -
SP2: - -
SP4: - -

Relevant External Links for RPS23 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPS23 Gene

Protein differential expression in normal tissues from HIPED for RPS23 Gene

This gene is overexpressed in Nasal epithelium (9.1), Cervix (8.4), and Tlymphocyte (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPS23 Gene

Protein tissue co-expression partners for RPS23 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS23 Gene:


SOURCE GeneReport for Unigene cluster for RPS23 Gene:


Evidence on tissue expression from TISSUES for RPS23 Gene

  • Nervous system(4.9)
  • Liver(4.4)
  • Muscle(4)
  • Lung(3.9)
  • Intestine(3.8)
  • Pancreas(3.8)
  • Eye(3.6)
  • Skin(3.3)
  • Blood(3)
  • Stomach(2.9)
  • Heart(2.8)
  • Spleen(2.8)
  • Lymph node(2.7)
  • Bone marrow(2.6)
  • Adrenal gland(2.5)
  • Thyroid gland(2.5)
  • Kidney(2.4)
  • Gall bladder(2.3)
genes like me logo Genes that share expression patterns with RPS23: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS23 Gene

Orthologs for RPS23 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS23 Gene

Organism Taxonomy Gene Similarity Type Details
(Monodelphis domestica)
Mammalia RPS23 34
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia RPS23 34
  • 100 (a)
(Pan troglodytes)
Mammalia RPS23 33 34
  • 99.3 (n)
(Bos Taurus)
Mammalia RPS23 33 34
  • 92.77 (n)
(Rattus norvegicus)
Mammalia Rps23 33
  • 90.68 (n)
(Mus musculus)
Mammalia Rps23 33 16 34
  • 89.74 (n)
(Canis familiaris)
Mammalia RPS23 33 34
  • 87.65 (n)
(Gallus gallus)
Aves RPS23 33 34
  • 83.92 (n)
(Anolis carolinensis)
Reptilia RPS23 34
  • 100 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rps23 33
  • 82.75 (n)
Str.1679 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.25836 33
(Danio rerio)
Actinopterygii rps23 33 34
  • 84.15 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8559 33
fruit fly
(Drosophila melanogaster)
Insecta CG8415 35
  • 90 (a)
RpS23 33 34
  • 76.46 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012990 33
  • 73.19 (n)
(Caenorhabditis elegans)
Secernentea rps-23 35 33 34
  • 71.79 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS23B 34
  • 77 (a)
RPS23A 33 34 36
  • 68.31 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B11231g 33
  • 66.2 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR108C 33
  • 65.96 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G09680 33
  • 69.95 (n)
(Glycine max)
eudicotyledons Gma.15234 33
(Oryza sativa)
Liliopsida Os.9075 33
(Triticum aestivum)
Liliopsida Ta.1335 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 86 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01552 33
  • 69.01 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps2302 33
  • 67.37 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5143 33
Species where no ortholog for RPS23 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPS23 Gene

Gene Tree for RPS23 (if available)
Gene Tree for RPS23 (if available)

Paralogs for RPS23 Gene

No data available for Paralogs for RPS23 Gene

Variants for RPS23 Gene

Sequence variations from dbSNP and Humsavar for RPS23 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000912449 -- 82,274,241(+) CTCCA(C/T)GGATA utr-variant-3-prime
rs1001150651 -- 82,277,554(+) ACAAA(C/T)GCTTT intron-variant, upstream-variant-2KB
rs1002144614 -- 82,273,243(+) CAGCC(A/G)TCCGT downstream-variant-500B
rs1002153132 -- 82,278,454(+) CTGGG(G/T)TCTCT upstream-variant-2KB
rs1002360698 -- 82,279,846(+) GGAGA(A/G)AAAGA intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for RPS23 Gene

Variant ID Type Subtype PubMed ID
nsv968216 CNV duplication 23825009
nsv830364 CNV loss 17160897
nsv520938 CNV gain 19592680
nsv1114699 CNV deletion 24896259
esv3605612 CNV loss 21293372
esv3566179 CNV deletion 23714750
esv2676657 CNV deletion 23128226

Variation tolerance for RPS23 Gene

Residual Variation Intolerance Score: 49.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.02; 0.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS23 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS23 Gene

Disorders for RPS23 Gene

MalaCards: The human disease database

(8) MalaCards diseases for RPS23 Gene - From: HGMD, OMIM, ClinVar, and DISEASES

Disorder Aliases PubMed IDs
brachycephaly, trichomegaly, and developmental delay
  • macinnes syndrome
retinitis pigmentosa 20
  • rp20
retinitis pigmentosa 26
  • rp26
spherocytosis, type 4
  • hereditary spherocytosis type 4
spherocytosis, type 1
  • hereditary spherocytosis type 1
- elite association - COSMIC cancer census association via MalaCards
Search RPS23 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RPS23

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RPS23: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS23 Gene

Publications for RPS23 Gene

  1. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N … Page DC (Genome research 1998) 2 3 4 60
  2. Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy. (PMID: 24550462) Loenarz C … Schofield CJ (Proceedings of the National Academy of Sciences of the United States of America 2014) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. (PMID: 8706699) Vladimirov SN … Otto A (European journal of biochemistry 1996) 3 4 60
  5. A cDNA sequence of human ribosomal protein, homologue of yeast S28. (PMID: 8415000) Hori N … Matsubara K (Nucleic acids research 1993) 3 4 60

Products for RPS23 Gene

Sources for RPS23 Gene

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