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Aliases for RPS23 Gene

Aliases for RPS23 Gene

  • Ribosomal Protein S23 2 3 5
  • Homolog Of Yeast Ribosomal Protein S28 3
  • 40S Ribosomal Protein S23 3
  • S23 3

External Ids for RPS23 Gene

Previous GeneCards Identifiers for RPS23 Gene

  • GC05M080389
  • GC05M081796
  • GC05M081608
  • GC05M081655
  • GC05M081607
  • GC05M076778
  • GC05M081569

Summaries for RPS23 Gene

Entrez Gene Summary for RPS23 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S12P family of ribosomal proteins. It is located in the cytoplasm. The protein shares significant amino acid similarity with S. cerevisiae ribosomal protein S28. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS23 Gene

RPS23 (Ribosomal Protein S23) is a Protein Coding gene. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Metabolism. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPS23 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS23 Gene

Genomics for RPS23 Gene

Regulatory Elements for RPS23 Gene

Enhancers for RPS23 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F082404 1.6 FANTOM5 Ensembl ENCODE 8.3 -127.2 -127245 3.3 PKNOX1 ZNF133 FEZF1 ZNF2 ZNF121 GLIS2 FOS KLF7 TSHZ1 ZNF488 ATG10 RPS23 ATP6AP1L LOC105379052 PIR35354 GC05P082523 GC05P082524
GH05F082412 0.9 Ensembl ENCODE 7.2 -135.0 -135047 1.8 MAFG CEBPB JUND MAFF ZNF316 CUX1 MAFK PRDM1 EMSY ATG10 ATP6AP1L RPS23 PIR35354 GC05P082523 GC05P082524
GH05F081970 1.1 ENCODE 4.4 +306.8 306801 2.8 HDGF ARNT MLX CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207 ATG10 ATP6AP1L RPS23 SEM1P1
GH05F082356 1.6 FANTOM5 Ensembl ENCODE 1.4 -78.9 -78924 3.0 PKNOX1 ATF1 ARNT CBX5 GATA2 FOS KDM4B JUNB NCOA1 REST ATG10 ATP6AP1L RPS23 GC05M082354 GC05M082258
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPS23 on UCSC Golden Path with GeneCards custom track

Promoters for RPS23 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001284248 77 2600 ARNT CREB3L1 ARID4B SIN3A DMAP1 YY1 CBX5 ZNF143 ZNF207 PAF1

Genomic Location for RPS23 Gene

Chromosome:
5
Start:
82,273,320 bp from pter
End:
82,278,577 bp from pter
Size:
5,258 bases
Orientation:
Minus strand

Genomic View for RPS23 Gene

Genes around RPS23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS23 Gene

Proteins for RPS23 Gene

  • Protein details for RPS23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62266-RS23_HUMAN
    Recommended name:
    40S ribosomal protein S23
    Protein Accession:
    P62266
    Secondary Accessions:
    • P39028
    • Q6IB08

    Protein attributes for RPS23 Gene

    Size:
    143 amino acids
    Molecular mass:
    15808 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS23 Gene

neXtProt entry for RPS23 Gene

Post-translational modifications for RPS23 Gene

  • Hydroxylation at Pro-62 affects translation termination efficiency.
  • Ubiquitination at Lys 37, Lys 48, and Lys 54
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS23 Gene

No data available for DME Specific Peptides for RPS23 Gene

Domains & Families for RPS23 Gene

Gene Families for RPS23 Gene

Protein Domains for RPS23 Gene

Suggested Antigen Peptide Sequences for RPS23 Gene

Graphical View of Domain Structure for InterPro Entry

P62266

UniProtKB/Swiss-Prot:

RS23_HUMAN :
  • Belongs to the ribosomal protein S12P family.
Family:
  • Belongs to the ribosomal protein S12P family.
genes like me logo Genes that share domains with RPS23: view

Function for RPS23 Gene

Molecular function for RPS23 Gene

GENATLAS Biochemistry:
60S ribosomal protein S23

Gene Ontology (GO) - Molecular Function for RPS23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA,IBA --
GO:0005515 protein binding IPI 20434207
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with RPS23: view
genes like me logo Genes that share phenotypes with RPS23: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS23 Gene

Localization for RPS23 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS23 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for RPS23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RPS23: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS23 Gene

Pathways & Interactions for RPS23 Gene

SuperPathways for RPS23 Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
.55
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing in the nucleus and cytosol
5 HIV Life Cycle
.45
genes like me logo Genes that share pathways with RPS23: view

Gene Ontology (GO) - Biological Process for RPS23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,IC 8706699
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPS23: view

No data available for SIGNOR curated interactions for RPS23 Gene

Transcripts for RPS23 Gene

Unigene Clusters for RPS23 Gene

Ribosomal protein S23:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS23 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7
SP1: - - -
SP2: - -
SP3:
SP4: - -
SP5:

Relevant External Links for RPS23 Gene

GeneLoc Exon Structure for
RPS23
ECgene alternative splicing isoforms for
RPS23

Expression for RPS23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPS23 Gene

Protein differential expression in normal tissues from HIPED for RPS23 Gene

This gene is overexpressed in Nasal epithelium (9.1), Cervix (8.4), and Tlymphocyte (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPS23 Gene



Protein tissue co-expression partners for RPS23 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS23 Gene:

RPS23

SOURCE GeneReport for Unigene cluster for RPS23 Gene:

Hs.527193
genes like me logo Genes that share expression patterns with RPS23: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS23 Gene

Orthologs for RPS23 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS23 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia RPS23 35
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPS23 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPS23 34 35
  • 99.3 (n)
cow
(Bos Taurus)
Mammalia RPS23 34 35
  • 92.77 (n)
rat
(Rattus norvegicus)
Mammalia Rps23 34
  • 90.68 (n)
mouse
(Mus musculus)
Mammalia Rps23 34 16 35
  • 89.74 (n)
dog
(Canis familiaris)
Mammalia RPS23 34 35
  • 87.65 (n)
chicken
(Gallus gallus)
Aves RPS23 34 35
  • 83.92 (n)
lizard
(Anolis carolinensis)
Reptilia RPS23 35
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rps23 34
  • 82.75 (n)
Str.1679 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.25836 34
zebrafish
(Danio rerio)
Actinopterygii rps23 34 35
  • 84.15 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8559 34
fruit fly
(Drosophila melanogaster)
Insecta CG8415 36
  • 90 (a)
RpS23 34 35
  • 76.46 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012990 34
  • 73.19 (n)
worm
(Caenorhabditis elegans)
Secernentea rps-23 36 34 35
  • 71.79 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS23B 35
  • 77 (a)
OneToMany
RPS23A 34 35 37
  • 68.31 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B11231g 34
  • 66.2 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR108C 34
  • 65.96 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G09680 34
  • 69.95 (n)
soybean
(Glycine max)
eudicotyledons Gma.15234 34
rice
(Oryza sativa)
Liliopsida Os.9075 34
wheat
(Triticum aestivum)
Liliopsida Ta.1335 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 86 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU01552 34
  • 69.01 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps23 34
  • 67.37 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5143 34
Species where no ortholog for RPS23 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPS23 Gene

ENSEMBL:
Gene Tree for RPS23 (if available)
TreeFam:
Gene Tree for RPS23 (if available)

Paralogs for RPS23 Gene

No data available for Paralogs for RPS23 Gene

Variants for RPS23 Gene

Sequence variations from dbSNP and Humsavar for RPS23 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1053173 -- 82,273,600(+) ACTAG(C/G)TTTAG utr-variant-3-prime
rs1053252 -- 82,273,930(+) TTTTT(C/T)TTTTA utr-variant-3-prime
rs111309881 -- 82,273,643(+) GTGCC(A/G)GGCTG utr-variant-3-prime
rs111339998 -- 82,277,854(+) TTGCC(A/C/T)AAAAA upstream-variant-2KB, splice-acceptor-variant
rs111515755 -- 82,278,022(+) ACTAA(C/T)AAACG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPS23 Gene

Variant ID Type Subtype PubMed ID
esv2676657 CNV deletion 23128226
esv3566179 CNV deletion 23714750
esv3605612 CNV loss 21293372
nsv1114699 CNV deletion 24896259
nsv520938 CNV gain 19592680
nsv830364 CNV loss 17160897
nsv968216 CNV duplication 23825009

Variation tolerance for RPS23 Gene

Residual Variation Intolerance Score: 49.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.02; 0.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS23 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPS23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS23 Gene

Disorders for RPS23 Gene

Relevant External Links for RPS23

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPS23

No disorders were found for RPS23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPS23 Gene

Publications for RPS23 Gene

  1. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3 4 64
  2. Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy. (PMID: 24550462) Loenarz C. … Schofield C.J. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PMID: 8706699) Vladimirov S.N. … Otto A. (Eur. J. Biochem. 1996) 3 4 64
  5. A cDNA sequence of human ribosomal protein, homologue of yeast S28. (PMID: 8415000) Hori N. … Matsubara K. (Nucleic Acids Res. 1993) 3 4 64

Products for RPS23 Gene

Sources for RPS23 Gene

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