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Aliases for RPS23 Gene

Aliases for RPS23 Gene

  • Ribosomal Protein S23 2 3
  • Homolog Of Yeast Ribosomal Protein S28 3
  • S23 3

External Ids for RPS23 Gene

Previous GeneCards Identifiers for RPS23 Gene

  • GC05M080389
  • GC05M081796
  • GC05M081608
  • GC05M081655
  • GC05M081607
  • GC05M076778
  • GC05M081569

Summaries for RPS23 Gene

Entrez Gene Summary for RPS23 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S12P family of ribosomal proteins. It is located in the cytoplasm. The protein shares significant amino acid similarity with S. cerevisiae ribosomal protein S28. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS23 Gene

RPS23 (Ribosomal Protein S23) is a Protein Coding gene. Among its related pathways are Infectious disease and Transport to the Golgi and subsequent modification. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPS23 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS23 Gene

Genomics for RPS23 Gene

Regulatory Elements for RPS23 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RPS23 Gene

Chromosome:
5
Start:
82,273,320 bp from pter
End:
82,278,577 bp from pter
Size:
5,258 bases
Orientation:
Minus strand

Genomic View for RPS23 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPS23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS23 Gene

Proteins for RPS23 Gene

  • Protein details for RPS23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62266-RS23_HUMAN
    Recommended name:
    40S ribosomal protein S23
    Protein Accession:
    P62266
    Secondary Accessions:
    • P39028
    • Q6IB08

    Protein attributes for RPS23 Gene

    Size:
    143 amino acids
    Molecular mass:
    15808 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS23 Gene

neXtProt entry for RPS23 Gene

Proteomics data for RPS23 Gene at MOPED

Post-translational modifications for RPS23 Gene

  • Hydroxylation at Pro-62 affects translation termination efficiency.
  • Ubiquitination at Lys 37, Lys 48, and Lys 54
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS23 Gene

Antibody Products

No data available for DME Specific Peptides for RPS23 Gene

Domains & Families for RPS23 Gene

Gene Families for RPS23 Gene

Protein Domains for RPS23 Gene

Suggested Antigen Peptide Sequences for RPS23 Gene

Graphical View of Domain Structure for InterPro Entry

P62266

UniProtKB/Swiss-Prot:

RS23_HUMAN :
  • Belongs to the ribosomal protein S12P family.
Family:
  • Belongs to the ribosomal protein S12P family.
genes like me logo Genes that share domains with RPS23: view

Function for RPS23 Gene

Molecular function for RPS23 Gene

GENATLAS Biochemistry:
60S ribosomal protein S23

Gene Ontology (GO) - Molecular Function for RPS23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IBA --
GO:0005515 protein binding IPI 20434207
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with RPS23: view
genes like me logo Genes that share phenotypes with RPS23: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPS23

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS23 Gene

Localization for RPS23 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS23 Gene COMPARTMENTS Subcellular localization image for RPS23 gene
Compartment Confidence
cytosol 5
nucleus 4

Gene Ontology (GO) - Cellular Components for RPS23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome NAS 8415000
genes like me logo Genes that share ontologies with RPS23: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS23 Gene

Pathways & Interactions for RPS23 Gene

SuperPathways for RPS23 Gene

genes like me logo Genes that share pathways with RPS23: view

Pathways by source for RPS23 Gene

1 BioSystems pathway for RPS23 Gene
1 KEGG pathway for RPS23 Gene
1 GeneGo (Thomson Reuters) pathway for RPS23 Gene

Gene Ontology (GO) - Biological Process for RPS23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
GO:0006415 translational termination TAS --
genes like me logo Genes that share ontologies with RPS23: view

No data available for SIGNOR curated interactions for RPS23 Gene

Drugs & Compounds for RPS23 Gene

No Compound Related Data Available

Transcripts for RPS23 Gene

Unigene Clusters for RPS23 Gene

Ribosomal protein S23:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPS23

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS23 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7
SP1: - - -
SP2: - -
SP3:
SP4: - -
SP5:

Relevant External Links for RPS23 Gene

GeneLoc Exon Structure for
RPS23
ECgene alternative splicing isoforms for
RPS23

Expression for RPS23 Gene

mRNA expression in normal human tissues for RPS23 Gene

Protein differential expression in normal tissues from HIPED for RPS23 Gene

This gene is overexpressed in Nasal epithelium (9.1), Cervix (8.4), and Tlymphocyte (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS23 Gene



SOURCE GeneReport for Unigene cluster for RPS23 Gene Hs.527193

genes like me logo Genes that share expression patterns with RPS23: view

Protein tissue co-expression partners for RPS23 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS23 Gene

Orthologs for RPS23 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS23 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPS23 35
  • 92.77 (n)
  • 100 (a)
RPS23 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPS23 35
  • 87.65 (n)
  • 100 (a)
RPS23 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rps23 35
  • 89.74 (n)
  • 100 (a)
Rps23 16
Rps23 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPS23 35
  • 99.3 (n)
  • 100 (a)
RPS23 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rps23 35
  • 90.68 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia RPS23 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPS23 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPS23 35
  • 83.92 (n)
  • 100 (a)
RPS23 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPS23 36
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rps23 35
  • 82.75 (n)
  • 97.9 (a)
Str.1679 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.25836 35
zebrafish
(Danio rerio)
Actinopterygii rps23 35
  • 84.15 (n)
  • 98.6 (a)
rps23 36
  • 99 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8559 35
fruit fly
(Drosophila melanogaster)
Insecta CG8415 37
  • 90 (a)
RpS23 35
  • 76.46 (n)
  • 90.91 (a)
RpS23 36
  • 91 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012990 35
  • 73.19 (n)
  • 89.51 (a)
worm
(Caenorhabditis elegans)
Secernentea rps-23 37
  • 84 (a)
rps-23 35
  • 71.79 (n)
  • 84.62 (a)
rps-23 36
  • 85 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR108C 35
  • 65.96 (n)
  • 78.87 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B11231g 35
  • 66.2 (n)
  • 78.17 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS23A 35
  • 68.31 (n)
  • 78.17 (a)
RPS23A 36
  • 77 (a)
OneToMany
RPS23B 36
  • 77 (a)
OneToMany
RPS23A 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G09680 35
  • 69.95 (n)
  • 76.06 (a)
soybean
(Glycine max)
eudicotyledons Gma.15234 35
rice
(Oryza sativa)
Liliopsida Os.9075 35
wheat
(Triticum aestivum)
Liliopsida Ta.1335 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5143 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01552 35
  • 69.01 (n)
  • 80.28 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps23 35
  • 67.37 (n)
  • 75.52 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 86 (a)
OneToOne
Species with no ortholog for RPS23:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPS23 Gene

ENSEMBL:
Gene Tree for RPS23 (if available)
TreeFam:
Gene Tree for RPS23 (if available)

Paralogs for RPS23 Gene

genes like me logo Genes that share paralogs with RPS23: view

No data available for Paralogs for RPS23 Gene

Variants for RPS23 Gene

Structural Variations from Database of Genomic Variants (DGV) for RPS23 Gene

Variant ID Type Subtype PubMed ID
nsv830364 CNV Loss 17160897
nsv520938 CNV Gain 19592680
esv2676657 CNV Deletion 23128226

Variation tolerance for RPS23 Gene

Residual Variation Intolerance Score: 49.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.02; 0.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS23 Gene

HapMap Linkage Disequilibrium report
RPS23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for RPS23 Gene

Disorders for RPS23 Gene

Relevant External Links for RPS23

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPS23
genes like me logo Genes that share disorders with RPS23: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPS23 Gene

Publications for RPS23 Gene

  1. A functional mouse retroposed gene Rps23r1 reduces Alzheimer's beta-amyloid levels and tau phosphorylation. (PMID: 19914182) Zhang Y.W. … Xu H. (Neuron 2009) 23 67
  2. Comparison of oligonucleotide-microarray and serial analysis of gene expression (SAGE) in transcript profiling analysis of megakaryocytes derived from CD34+ cells. (PMID: 14646601) Kim H.L. (Exp. Mol. Med. 2003) 23 67
  3. [Cloning of differentially expressed cDNA sequences involved in malignant transformation induced by benzo(a)pyrene metabolite dihydroxyepoxy benzo pyrene]. (PMID: 12515615) Jiang Y. … Yi F. (Zhonghua Zhong Liu Za Zhi 2002) 23 67
  4. DNA microarray analysis of gene expression markers of endometriosis. (PMID: 11779588) Eyster K.M. … Hansen K.A. (Fertil. Steril. 2002) 23 67
  5. Differential expression of the L-plastin gene in human colorectal cancer progression and metastasis. (PMID: 11735128) Otsuka M. … Seki N. (Biochem. Biophys. Res. Commun. 2001) 23 67

Products for RPS23 Gene

Sources for RPS23 Gene

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