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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPS21 Gene

protein-coding   GIFtS: 56
GCID: GC20P060962

ribosomal protein S21
 Explore 5 diseases affiliated with
RPS21 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RPS21    

Aliases
for RPS21 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ribosomal Protein S211 2
S211 2
40S Ribosomal Protein S212
8.2 KDa Differentiation Factor2

External Ids:    HGNC: 104091   Entrez Gene: 62272   Ensembl: ENSG000001718587   OMIM: 1804775   UniProtKB: P632203   

Export aliases for RPS21 gene to outside databases

Previous GC identifers: GC20P060725 GC20P061600 GC20P061647 GC20P060395


Summaries
for RPS21 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RPS21:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene
encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S21E family of
ribosomal proteins. It is located in the cytoplasm. Alternative splice variants that encode different protein isoforms
have been described, but their existence has not been verified. As is typical for genes encoding ribosomal proteins,
there are multiple processed pseudogenes of this gene dispersed through the genome. (provided by RefSeq, Jul 2008)

Gene Wiki entry for RPS21


Genomic Views
for RPS21 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPS21 gene promoter:
         HFH-3   Pax-2   MyoD   Pax-2a   AP-2gamma   FOXI1   Pax-2b   AP-2beta   AP-2alpha   AP-2alphaA   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for RPS21

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.3   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.3

RPS21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS21 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P060962:  view genomic region     (about GC identifiers)

Start:
 60,962,105 bp from pter      End:
 60,963,576 bp from pter
Size:
 1,472 bases      Orientation:
 plus strand

Proteins
for RPS21 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RS21_HUMAN, P63220 (See protein sequence)
Recommended Name: 40S ribosomal protein S21  
Size: 83 amino acids; 9111 Da
Secondary accessions: P35265

Explore the universe of human proteins at neXtProt for RPS21: NX_P63220

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P63220

    • RPS21 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001015.1  
    ENSEMBL proteins: 
     ENSP00000359624   ENSP00000324438   ENSP00000359593   ENSP00000345957   ENSP00000388332  
    Reactome Protein details: P63220
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: RPS21
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    Novus Biologicals RPS21 Proteins
    Novus Biologicals RPS21 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RPS21

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005840ribosome ----
    GO:0015935small ribosomal subunit IDA15883184
    GO:0022627cytosolic small ribosomal subunit NAS8332502


    RPS21 for ontologies           About GeneDecksing



    RPS21 Antibody Products: 
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    Uscn ELISAs and CLIAs for RPS21

    Protein Domains /
    Families
    for RPS21 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RPS21 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001931 Ribosomal_S21e
     IPR018279 Ribosomal_S21e_CS

    Graphical View of Domain Structure for InterPro Entry P63220

    ProtoNet protein and cluster: P63220

    UniProtKB/Swiss-Prot: RS21_HUMAN, P63220
    Similarity: Belongs to the ribosomal protein S21e family


    Function
    for RPS21 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:
         Genatlas biochemistry entry for RPS21:
    40S ribosomal protein S21,9kDa

    miRNA
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    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPS21 (see all 6)
    OriGene shRNA RFP: RPS21
    Browse OriGene siRNA
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RPS21

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPS21 (see all 4)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS21 

    Cell Line
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    Search LifeMap BioReagents cell lines for RPS21

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RPS21

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome IBA--
    GO:0047485protein N-terminus binding IPI10079194


    RPS21 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for RPS21:
     Cytoplasmic 40S maturation def  Decreased G3BP1 protein expres  Increased gamma-H2AX phosphory  Nucleolar pre-40S maturation d 


    Pathways & Interactions
    for RPS21 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Synthesis of PB1-F2
    8/26 pathways (see all 26)
    		Viral Protein Synthesis1.00
    		Cytoplasmic Ribosomal Proteins0.86
    		Viral mRNA Translation1.00
    		CFTR translational fidelity (class I mutations)0.83
    		Influenza Viral RNA Transcription and Replication1.00
    		SMG6 Cleaves mRNA with Premature Termination Codon0.80
    		Synthesis of nascent polypeptide containing signal sequence1.00
    		L13a-mediated translational silencing of Ceruloplasmin expression0.79
    2Translation initiation complex formation
    		Translation initiation complex formation1.00
    		Ribosomal scanning and start codon recognition0.96
    		Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.98
    		Formation of the ternary complex, and subsequently, the 43S complex0.87
    3Metabolism of mRNA
    		Metabolism of mRNA1.00
    		Metabolism of RNA0.92
    4Disease
    		Disease1.00
    5Generic Transcription Pathway
    		Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPS21
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPS21 
        Cytoplasmic Ribosomal Proteins

    5/32        Reactome Pathways for RPS21 (see all 32)
        Formation of a pool of free 40S subunits
    Synthesis of PB1-F2
    SMG6 Cleaves mRNA with Premature Termination Codon
    Influenza Life Cycle
    Viral mRNA Translation


    1         Kegg Pathway  (Kegg details for RPS21):
        Ribosome


    RPS21 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RPS21

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/227 Interacting proteins for RPS21 (P632202, 3 ENSP000003244384) via UniProtKB, MINT, STRING, and/or I2D (see all 227)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RIOK2Q9BVS43, ENSP000002831094I2D: score=2 STRING: ENSP00000283109
    RPSAP088653, ENSP000003460674I2D: score=11 STRING: ENSP00000346067
    ABCF2Q9UG633, ENSP000002223884I2D: score=1 STRING: ENSP00000222388
    KRR1Q136013, ENSP000002292144I2D: score=1 STRING: ENSP00000229214
    MCTS1Q9ULC43, ENSP000003603654I2D: score=1 STRING: ENSP00000360365
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA--
    GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--


    RPS21 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RPS21 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RPS21
    Search CenterWatch for drugs/clinical trials and news about RPS21 / RS21 

    Transcripts
    for RPS21 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RPS21 gene: 
    NM_001024.3  

    Unigene Cluster for RPS21:

    Ribosomal protein S21
    Hs.190968  [show with all ESTs]
    Unigene Representative Sequence: BG032620
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370592 ENST00000317311 ENST00000492356(uc002ycs.3) ENST00000370562(uc002yct.3)
    ENST00000343986(uc002ycr.3) ENST00000450116

    miRNA
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    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPS21 (see all 6)
    OriGene shRNA RFP: RPS21
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS21
    Clone
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    GenScript: all cDNA clones in your preferred vector: RPS21 (NM_001024)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS21
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS21

    Additional cDNA sequence: 

    BC018140.1 BC021990.1 BC071927.1 CR542132.1 L04483.1 X79563.2 

    24/42 DOTS entries (see all 42):

    DT.95339392  DT.100890163  DT.120811850  DT.95264766  DT.95212695  DT.100890133  DT.100890144  DT.101956201 
    DT.120811651  DT.91789943  DT.120811809  DT.91779554  DT.121644190  DT.75169017  DT.100045444  DT.120811701 
    DT.120811805  DT.101956202  DT.120811613  DT.100890126  DT.100890129  DT.100890146  DT.120811716  DT.120811836 

    24/567 AceView cDNA sequences (see all 567):

    BF792813 AV691666 CB114115 AJ713168 CR593203 BM738521 CB112947 BM840415 
    AI681381 BU557101 BQ643458 BQ070366 BF974135 CB113902 AJ713327 BM852578 
    BE336925 BG686373 BM840278 NM_001024 BM794524 AJ346675 BU156658 BQ222674 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RPS21    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b
    SP1:              -                 -           -                     
    SP2:                                -           -                     
    SP3:              -                 -                                 
    SP4:                                                                  


    ECgene alternative splicing isoforms for RPS21

    Expression
    for RPS21 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPS21 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTATAGTCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RPS21 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TrophoblastMural TrophectodermMural Trophectoderm CellsExtraembryonic Tissues
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RPS21 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPS21

    SOURCE GeneReport for Unigene cluster: Hs.190968
        SABiosciences Custom PCR Arrays for RPS21
    Primer
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    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RPS21

    Orthologs
    for RPS21 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPS21 gene from 10/34 species (see all 34)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rps211 , 5 ribosomal protein S211, 5 91.57(n)1
    95.18(a)1    		   2 (102.78 cM)5
    664811  NM_025587.21  NP_079863.11 
     1802573775 
    chicken
    (Gallus gallus)    		 Aves RPS211 ribosomal protein S21 82.88(n)
    94.59(a)    		   419228  XM_417405.3  XP_417405.3 
    lizard
    (Anolis carolinensis)    		 Reptilia RPS216
    		 --
    		 93(a)
    		 1 ↔ 1
    		 4(151274352-151277262)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.292652 Xenopus laevis transcribed sequence with strong similarity more 79.09(n)    48036029 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc566422 similar to ribosomal protein S21 79.69(n)   394166  BC049056.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta RpS211 Ribosomal protein S21 67.87(n)
    73.49(a)    		   33487  NM_164506.3  NP_722853.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea rps-211 Protein RPS-21 63.82(n)
    68.29(a)    		   176011  NM_066178.5  NP_498579.2 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes RPS21A(YKR057W)4
    RPS21A1    		 Protein component of the small (40S) ribosomal subunit; more4
    Rps21ap1    		 60.34(n)1
    58.23(a)1    		   11(551657-552242)4
    8539311, 4  NP_012983.31  NP_012983.14 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G538906
    AT5G277006
    		 small subunit ribosomal protein S21e
    		 46(a)
    45(a)
    		 many → 1
    many → 1
    		 3(19955344-19956361)
    5(9807302-9808506)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 40S ribosomal protein S21, putative, expressed
    		 50(a)
    		 1 ↔ 1
    		 3(26301600-26305942)


    ENSEMBL Gene Tree for RPS21 (if available)
    TreeFam Gene Tree for RPS21 (if available) 

    Paralogs
    for RPS21 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPS21 gene
    1 SIMAP similar gene for RPS21 using alignment to 5 protein entries:     RS21_HUMAN (see all proteins):
    TBCE

    RPS21 for paralogs           About GeneDecksing


    5/8 Pseudogenes.org Pseudogenes for RPS21 (see all 8)
    PGOHUM00000262887 PGOHUM00000262999 PGOHUM00000247434 PGOHUM00000263085 PGOHUM00000263097


    Genomic Variants
    for RPS21 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/121 NCBI SNPs in RPS21 are shown (see all 121)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 20 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs130364951,2
    		C,F,A,--60960144(+) GACAGA/GGCAAG 1 -- us2k14Minor allele frequency- G:0.38NA WA 8
    rs1114668981,2
    		C,--60960159(+) CGTCTCAAAC   
       AAA    /-    CAAAC     		1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1858348481,2
    		--60960201(+) ACTAAA/GAATAG 1 -- us2k10--------
    rs60615051,2
    		C,A,--60960211(+) GAGCTG/ACCATA 1 -- us2k110Minor allele frequency- A:0.40NA WA CSA EA 370
    rs1902962691,2
    		--60960286(+) CCTGGC/TCGGGT 1 -- us2k10--------
    rs1824552761,2
    		--60960334(+) GCTGAC/GGCAGG 1 -- us2k10--------
    rs1435968841,2
    		--60960539(+) GACAGC/TAGAAA 1 -- us2k10--------
    rs1493810121,2
    		C,F,--60960734(+) TTGTAA/TCGCAA 1 -- us2k11Minor allele frequency- T:0.02NS 148
    rs1144433141,2
    		F,--60960803(+) CATGCC/TGGTAT 1 -- us2k11Minor allele frequency- T:0.06WA 118
    rs1173788071,2
    		F,--60960843(+) CACACC/ACACTA 1 -- us2k11Minor allele frequency- A:0.05EA 120

    HapMap Linkage Disequilibrium report for RPS21 (60962105 - 60963576 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 9 variations for RPS21
         9 CNVs: 29710 4106 5347 30131 30128 30130 50706 30127 53671

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    Disorders / Diseases
    for RPS21 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RPS21 for disorders           About GeneDecksing

    OMIM gene information: 180477    OMIM disorders: --

    5 diseases for RPS21:    About MalaCards
    pure red-cell aplasia    diamond-blackfan anemia    anemia    malaria
    leukemia


    Export disorders for RPS21 gene to outside databases

    Publications
    for RPS21 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPS21 gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with RPS21)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Primary structure of human ribosomal protein S21. (PubMed id 8332502)1, 2, 3, 9 Bhat K.S. and Morrison S.G. (1993)
    2. A map of 75 human ribosomal protein genes. (PubMed id 9582194)1, 2, 3 Kenmochi N.... Page D.C. (1998)
    3. Cloning and characterization of the human ribosomal protein S21 gene. (PubMed id 10900511)1, 2, 9 Smirnova E.V....Lipkin V.M. (2000)
    4. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PubMed id 11875025)1, 2 Yoshihama M.... Kenmochi N. (2002)
    5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    6. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699)1, 2 Vladimirov S.N.... Otto A. (1996)
    7. Ribosome-associated protein LBP/p40 binds to S21 protein of 40S ribosome: analysis using a yeast two-hybrid system. (PubMed id 10079194)1, 9 Sato M.... Kaneda Y. (1999)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    10. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)

    External Searches for RPS21 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
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    OMIM
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    Genome Databases showing RPS21 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6227 HGNC: 10409 AceView: RPS21 Ensembl:ENSG00000171858 euGenes: HUgn6227
    ECgene: RPS21 Kegg: 6227 H-InvDB: RPS21

    Other Databases showing RPS21 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RPS21 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPS21 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RPS21 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RPS21 gene:
    Search GeneIP for patents involving RPS21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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