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RPS21 Gene

protein-coding   GIFtS: 58
GCID: GC20P060962

Ribosomal Protein S21

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 4

Aliases
Ribosomal Protein S211 2
8.2 KDa Differentiation Factor1 2
40S Ribosomal Protein S212
HLDF2
S212
Human Leukemia Differentiation Factor2

External Ids:    HGNC: 104091   Entrez Gene: 62272   Ensembl: ENSG000001718587   OMIM: 1804775   UniProtKB: P632203   
ORGUL members:    fRNAdb10:FR074307      
H-InvDB12:HIT000101251    
NCBI13:D28422    
RNAdb15:HIV2758    

Export aliases for RPS21 gene to outside databases

Previous GC identifers: GC20P060725 GC20P061600 GC20P061647 GC20P060395


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RPS21 Gene:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This
gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S21E family
of ribosomal proteins. It is located in the cytoplasm. Alternative splice variants that encode different protein
isoforms have been described, but their existence has not been verified. As is typical for genes encoding
ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. (provided
by RefSeq, Jul 2008)

GeneCards Summary for RPS21 Gene:
RPS21 (ribosomal protein S21) is a protein-coding gene. Diseases associated with RPS21 include pure red-cell aplasia, and diamond-blackfan anemia. GO annotations related to this gene include structural constituent of ribosome and protein N-terminus binding.

Gene Wiki entry for RPS21 Gene

fRNAdb sequence ontology for RPS21:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for RPS21

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPS21 gene promoter:
         HFH-3   Pax-2   MyoD   Pax-2a   AP-2gamma   FOXI1   Pax-2b   AP-2beta   AP-2alpha   AP-2alphaA   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for RPS21

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPS21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.3   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.3

RPS21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS21 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P060962:  view genomic region     (about GC identifiers)

Start:
60,962,121 bp from pter      End:
60,963,576 bp from pter
Size:
1,456 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RS21_HUMAN, P63220 (See protein sequence)
Recommended Name: 40S ribosomal protein S21  
Size: 83 amino acids; 9111 Da
1 PDB 3D structure from and Proteopedia for RPS21:
3J3A (3D)    
Secondary accessions: P35265

Explore the universe of human proteins at neXtProt for RPS21: NX_P63220

Explore proteomics data for RPS21 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys27, Lys51, Lys74, Lys81
  • Modification sites at PhosphoSitePlus

  • See RPS21 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001015.1  
    ENSEMBL proteins: 
     ENSP00000345957   ENSP00000359593   ENSP00000359624   ENSP00000388332  
    Reactome Protein details: P63220

    RPS21 Human Recombinant Protein Products:

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    Novus Biologicals RPS21 Proteins
    Novus Biologicals RPS21 Lysates
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for RPS21

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    RPS21 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RPS: S ribosomal proteins

    2 InterPro protein domains:
     IPR001931 Ribosomal_S21e
     IPR018279 Ribosomal_S21e_CS

    Graphical View of Domain Structure for InterPro Entry P63220

    ProtoNet protein and cluster: P63220

    UniProtKB/Swiss-Prot: RS21_HUMAN, P63220
    Similarity: Belongs to the ribosomal protein S21e family


    RPS21 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for RPS21:
    40S ribosomal protein S21,9kDa

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome IBA--
    GO:0044822poly(A) RNA binding IDA--
    GO:0047485protein N-terminus binding IPI10079194
         
    RPS21 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for RPS21:
     Cytoplasmic 40S maturation def  Decreased G3BP1 protein expres  Increased gamma-H2AX phosphory  Nucleolar pre-40S maturation d 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RPS21
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RPS21

    miRNA
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    miRTarBase miRNAs that target RPS21:
    hsa-mir-186-5p (MIRT044996)

    Block miRNA regulation of human, mouse, rat RPS21 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate RPS21
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RPS21

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    GenScript: all cDNA clones in your preferred vector: RPS21 (NM_001024)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS21


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus2
    extracellular1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005840ribosome ----
    GO:0015935small ribosomal subunit IDA15883184

    RPS21 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RPS21 About   (see all 6)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CFTR translational fidelity class I mutations
    CFTR translational fidelity class I mutations 0.60
    Ribosome0.54
    Cytoplasmic Ribosomal Proteins0.60
    2Influenza Viral RNA Transcription and Replication
    Viral mRNA Translation0.94
    Eukaryotic Translation Initiation0.89
    Peptide chain elongation0.94
    Cap-dependent Translation Initiation0.89
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    Formation of a pool of free 40S subunits0.94
    Nonsense-Mediated Decay0.89
    3Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
    Translation initiation complex formation0.91
    Ribosomal scanning and start codon recognition0.91
    Formation of the ternary complex, and subsequently, the 43S complex0.91
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.90
    4Gene Expression
    Gene Expression0.40
    5Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPS21
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPS21
        Cytoplasmic Ribosomal Proteins

    Selected Reactome Pathways for RPS21 (see all 12)
        Peptide chain elongation
    Formation of the ternary complex, and subsequently, the 43S complex
    Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
    Viral mRNA Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit


    1 Kegg Pathway  (Kegg details for RPS21):
        Ribosome


    RPS21 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RPS21
    Interactions:

        GeneGlobe Interaction Network for RPS21

    Selected Interacting proteins for RPS21 (P632202, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 67)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000096150P622693I2D: score=1 
    ENSG00000223367P622693I2D: score=1 
    ENSG00000226225P622693I2D: score=1 
    ENSG00000235650P622693I2D: score=1 
    RPS18P622693I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA--
    GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--

    RPS21 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPS21 (RS21)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    1 fRNAdb Secondary structure:


    REFSEQ mRNAs for RPS21 gene: 
    NM_001024.3  

    Unigene Cluster for RPS21:

    Ribosomal protein S21
    Hs.190968  [show with all ESTs]
    Unigene Representative Sequence: BG032620
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000343986(uc002ycr.3) ENST00000492356(uc002ycs.3) ENST00000370562(uc002yct.3)
    ENST00000370592 ENST00000450116
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    GenScript: all cDNA clones in your preferred vector: RPS21 (NM_001024)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS21
    Primer
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    OriGene qPCR primer pairs and template standards for RPS21
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    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat RPS21
      QuantiTect SYBR Green Assays in human, mouse, rat RPS21
      QuantiFast Probe-based Assays in human, mouse, rat RPS21

    Additional mRNA sequence: 

    BC018140.1 BC021990.1 BC071927.1 CR542132.1 L04483.1 X79563.2 

    Selected DOTS entries (see all 43):

    DT.95339392  DT.100890163  DT.120811850  DT.95212695  DT.95264766  DT.100890133  DT.100890144  DT.101956201 
    DT.120811651  DT.91789943  DT.120811809  DT.91779554  DT.121644190  DT.100045444  DT.75169017  DT.120811701 
    DT.120811805  DT.100890146  DT.101956202  DT.120811613  DT.120811716  DT.100890126  DT.100890129  DT.120811683 

    Selected AceView cDNA sequences (see all 567):

    BQ643458 BM840415 BU557101 AI681381 BM738521 CB114115 CB112947 BF792813 
    CR593203 AV691666 BM988292 AJ713168 BE336925 BG686373 BM852578 NM_001024 
    BM840278 BM794524 BQ070366 AJ713327 AJ346675 BU156658 BQ222674 BM561052 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RPS21    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b
    SP1:              -                 -           -                     
    SP2:                                -           -                     
    SP3:              -                 -                                 
    SP4:                                                                  


    ECgene alternative splicing isoforms for RPS21

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RPS21 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTATAGTCT
    RPS21 Expression
    About this image


    RPS21 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Mural Trophectoderm Cells Mural Trophectoderm
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Bone marrow-derived hematopoietic stem cells (family)
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
    RPS21 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPS21 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.190968
        Custom PCR Arrays for RPS21
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS21

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPS21 gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rps211 , 5 ribosomal protein S211, 5 91.57(n)1
    95.18(a)1
      2 (102.78 cM)5
    664811  NM_025587.21  NP_079863.11 
     1802573775 
    chicken
    (Gallus gallus)
    Aves RPS211 ribosomal protein S21 82.88(n)
    94.59(a)
      419228  XM_417405.4  XP_417405.3 
    lizard
    (Anolis carolinensis)
    Reptilia RPS216
    ribosomal protein S21
    93(a)
    1 ↔ 1
    4(151272678-151280852)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.292652 Xenopus laevis transcribed sequence with strong similarity more 79.09(n)    48036029 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc566422 similar to ribosomal protein S21 79.69(n)   394166  BC049056.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RpS211 Ribosomal protein S21 67.87(n)
    73.49(a)
      33487  NM_164507.4  NP_722854.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rps-211 rps-21 63.82(n)
    68.29(a)
      176011  NM_066178.6  NP_498579.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPS21A(YKR057W)4
    RPS21A1
    Protein component of the small (40S) ribosomal subunit; more4
    RPS21A1
    60.34(n)1
    58.23(a)1
      11(551657-552242)4
    8539311, 4  NP_012983.31  NP_012983.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G538901 AT3G53890 56.25(n)
    47.5(a)
      824556  NM_001084811.1  NP_001078280.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g03452001 Os03g0345200 62.56(n)
    56.16(a)
      4332813  NM_001056623.1  NP_001050088.1 


    ENSEMBL Gene Tree for RPS21 (if available)
    TreeFam Gene Tree for RPS21 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RPS21 gene

    RPS21 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for RPS21 (see all 8)
    PGOHUM00000262887 PGOHUM00000262999 PGOHUM00000247434 PGOHUM00000263085 PGOHUM00000263097


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RPS21 (see all 106)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs130364951,2
    C,F,A--60960144(+) gacagA/Ggcaag 1 -- us2k14Minor allele frequency- G:0.38NA WA 8
    rs1114668981,2
    C--60960159(+) CGTCTCAAAC   
       AAA
    /-
    CAAAC
    1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1858348481,2
    --60960201(+) ACTAAA/GAATAG 1 -- us2k10--------
    rs60615051,2
    C,A--60960211(+) gagctG/Accata 1 -- us2k110Minor allele frequency- A:0.40NA WA CSA EA 370
    rs1902962691,2
    --60960286(+) CCTGGC/TCGGGT 1 -- us2k10--------
    rs1824552761,2
    --60960334(+) GCTGAC/GGCAGG 1 -- us2k10--------
    rs1435968841,2
    --60960539(+) GACAGC/TAGAAA 1 -- us2k10--------
    rs1493810121,2
    C,F--60960734(+) TTGTAA/TCGCAA 1 -- us2k11Minor allele frequency- T:0.02NS 148
    rs1144433141,2
    F--60960803(+) CATGCC/TGGTAT 1 -- us2k11Minor allele frequency- T:0.06WA 118
    rs1173788071,2
    C,F--60960843(+) CACACC/ACACTA 1 -- us2k11Minor allele frequency- A:0.05EA 120

    HapMap Linkage Disequilibrium report for RPS21 (60962121 - 60963576 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RPS21 (see all 20):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422398CNV Duplication17116639
    dgv518n27CNV Loss19166990
    dgv4602n71CNV Loss21882294
    dgv4599n71CNV Loss21882294
    nsv459067CNV Loss19166990
    dgv4603n71CNV Loss21882294
    nsv470556CNV Loss18288195
    nsv828774CNV Loss20364138
    dgv4605n71CNV Loss21882294
    nsv913073CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 180477OMIM information: 217400 605804 607116 608031 608559 610245    
    7 diseases for RPS21:    
    About MalaCards
    pure red-cell aplasia    diamond-blackfan anemia    influenza    malaria
    prostate cancer    leukemia    prostatitis


    RPS21 for disorders           About GeneDecksing


    Export disorders for RPS21 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RPS21 gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with RPS21)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Primary structure of human ribosomal protein S21. (PubMed id 8332502)1, 2, 3, 9 Bhat K.S. and Morrison S.G. (Nucleic Acids Res. 1993)
    2. A map of 75 human ribosomal protein genes. (PubMed id 9582194)1, 2, 3 Kenmochi N.... Page D.C. (Genome Res. 1998)
    3. Cloning and characterization of the human ribosomal protein S21 gene. (PubMed id 10900511)1, 2, 9 Smirnova E.V....Lipkin V.M. (Bioorg. Khim. 2000)
    4. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PubMed id 11875025)1, 2 Yoshihama M.... Kenmochi N. (Genome Res. 2002)
    5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    6. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699)1, 2 Vladimirov S.N.... Otto A. (Eur. J. Biochem. 1996)
    7. Ribosome-associated protein LBP/p40 binds to S21 protein of 40S ribosome: analysis using a yeast two-hybrid system. (PubMed id 10079194)1, 9 Sato M.... Kaneda Y. (Biochem. Biophys. Res. Commun. 1999)
    8. Structures of the human and Drosophila 80S ribosome. (PubMed id 23636399)2 Anger A.M.... Beckmann R. (Nature 2013)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PubMed id 23535732)1 Eeles R.A....Easton D.F. (Nat. Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 6227 HGNC: 10409 AceView: RPS21 Ensembl:ENSG00000171858 euGenes: HUgn6227
    ECgene: RPS21 Kegg: 6227 H-InvDB: RPS21

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RPS21 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RPS21 gene:
    Search GeneIP for patents involving RPS21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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