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Aliases for RPS20 Gene

Aliases for RPS20 Gene

  • Ribosomal Protein S20 2 3 5
  • S20 3

External Ids for RPS20 Gene

Previous GeneCards Identifiers for RPS20 Gene

  • GC08M056164
  • GC08M056924
  • GC08M056704
  • GC08M057035
  • GC08M057148
  • GC08M056982

Summaries for RPS20 Gene

Entrez Gene Summary for RPS20 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S10P family of ribosomal proteins. It is located in the cytoplasm. This gene is co-transcribed with the small nucleolar RNA gene U54, which is located in its second intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Apr 2009]

GeneCards Summary for RPS20 Gene

RPS20 (Ribosomal Protein S20) is a Protein Coding gene. Diseases associated with RPS20 include familial colorectal cancer type x. Among its related pathways are Gene Expression and Metabolism. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPS20 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS20 Gene

Genomics for RPS20 Gene

Regulatory Elements for RPS20 Gene

Promoters for RPS20 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPS20 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPS20 Gene

Chromosome:
8
Start:
56,067,295 bp from pter
End:
56,074,581 bp from pter
Size:
7,287 bases
Orientation:
Minus strand

Genomic View for RPS20 Gene

Genes around RPS20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS20 Gene

Proteins for RPS20 Gene

  • Protein details for RPS20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60866-RS20_HUMAN
    Recommended name:
    40S ribosomal protein S20
    Protein Accession:
    P60866
    Secondary Accessions:
    • B2R4F4
    • B4DW28
    • P17075
    • Q5M8S9

    Protein attributes for RPS20 Gene

    Size:
    119 amino acids
    Molecular mass:
    13373 Da
    Quaternary structure:
    • Component of the 40S small ribosomal subunit.

    Three dimensional structures from OCA and Proteopedia for RPS20 Gene

    Alternative splice isoforms for RPS20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPS20 Gene

Proteomics data for RPS20 Gene at MOPED

Post-translational modifications for RPS20 Gene

  • Ubiquitination at Lys 30, Lys 34, Lys 67, and Lys 75
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPS20 Gene

Domains & Families for RPS20 Gene

Gene Families for RPS20 Gene

Protein Domains for RPS20 Gene

Suggested Antigen Peptide Sequences for RPS20 Gene

Graphical View of Domain Structure for InterPro Entry

P60866

UniProtKB/Swiss-Prot:

RS20_HUMAN :
  • Belongs to the ribosomal protein S10P family.
Family:
  • Belongs to the ribosomal protein S10P family.
genes like me logo Genes that share domains with RPS20: view

Function for RPS20 Gene

Molecular function for RPS20 Gene

GENATLAS Biochemistry:
40S ribosomal protein S20

Gene Ontology (GO) - Molecular Function for RPS20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18274552
genes like me logo Genes that share ontologies with RPS20: view
genes like me logo Genes that share phenotypes with RPS20: view

Human Phenotype Ontology for RPS20 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for RPS20

miRNA for RPS20 Gene

miRTarBase miRNAs that target RPS20

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS20 Gene

Localization for RPS20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS20 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS20 Gene COMPARTMENTS Subcellular localization image for RPS20 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 2
plasma membrane 2
chloroplast 1
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPS20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015935 small ribosomal subunit IEA --
GO:0016020 membrane IDA 19946888
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with RPS20: view

Pathways & Interactions for RPS20 Gene

SuperPathways for RPS20 Gene

Superpath Contained pathways
1 Viral mRNA Translation
.60
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 Infectious disease
.48
5 rRNA processing
genes like me logo Genes that share pathways with RPS20: view

Pathways by source for RPS20 Gene

1 BioSystems pathway for RPS20 Gene
1 KEGG pathway for RPS20 Gene
1 GeneGo (Thomson Reuters) pathway for RPS20 Gene

Gene Ontology (GO) - Biological Process for RPS20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS --
GO:0006413 translational initiation TAS --
GO:0006415 translational termination TAS --
GO:0016032 viral process TAS --
GO:0019058 viral life cycle TAS --
genes like me logo Genes that share ontologies with RPS20: view

No data available for SIGNOR curated interactions for RPS20 Gene

Drugs & Compounds for RPS20 Gene

No Compound Related Data Available

Transcripts for RPS20 Gene

Unigene Clusters for RPS20 Gene

Ribosomal protein S20:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPS20 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c
SP1: - -
SP2: - - -
SP3: -
SP4: -
SP5:
SP6: - - - -

Relevant External Links for RPS20 Gene

GeneLoc Exon Structure for
RPS20
ECgene alternative splicing isoforms for
RPS20

Expression for RPS20 Gene

mRNA expression in normal human tissues for RPS20 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS20 Gene



SOURCE GeneReport for Unigene cluster for RPS20 Gene Hs.8102

genes like me logo Genes that share expression patterns with RPS20: view

Protein tissue co-expression partners for RPS20 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS20 Gene

Orthologs for RPS20 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPS20 36
  • 99 (a)
OneToOne
RPS20 35
  • 100 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia RPS20 35
  • 88.8 (n)
  • 100 (a)
RPS20 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 77 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
-- 36
  • 96 (a)
OneToMany
RPS20 35
  • 90.48 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Rps20 35
  • 89.64 (n)
  • 100 (a)
Rps20 16
Rps20 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RPS20 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPS20 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rps20 35
  • 89.64 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves RPS20 35
  • 82.63 (n)
  • 98.32 (a)
RPS20 36
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1787 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rbm6 35
  • 79.27 (n)
  • 96.64 (a)
Str.17075 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10529 35
zebrafish
(Danio rerio)
Actinopterygii Dr.280 35
rps20 35
  • 79.83 (n)
  • 97.48 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010591 35
  • 67.52 (n)
  • 82.91 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpS20 35
  • 69.23 (n)
  • 81.2 (a)
RpS20 36
  • 77 (a)
OneToOne
RpS20 37
  • 81 (a)
worm
(Caenorhabditis elegans)
Secernentea rps-20 35
  • 66.01 (n)
  • 80.2 (a)
rps-20 36
  • 71 (a)
OneToOne
Y105E8A.16 37
  • 80 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR041C 35
  • 58.79 (n)
  • 54.55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS20 36
  • 51 (a)
OneToOne
RPS20 38
RPS20 35
  • 64.03 (n)
  • 62.38 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F25542g 35
  • 61.52 (n)
  • 62.73 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.767 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G62300 35
  • 68.21 (n)
  • 74.07 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.3696 35
rice
(Oryza sativa)
Liliopsida Os06g0134000 35
  • 66.67 (n)
  • 76.24 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06892 35
  • 65.74 (n)
  • 72.22 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps20 35
  • 71.57 (n)
  • 80.39 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6589 35
Species with no ortholog for RPS20:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS20 Gene

ENSEMBL:
Gene Tree for RPS20 (if available)
TreeFam:
Gene Tree for RPS20 (if available)

Paralogs for RPS20 Gene

genes like me logo Genes that share paralogs with RPS20: view

No data available for Paralogs for RPS20 Gene

Variants for RPS20 Gene

Sequence variations from dbSNP and Humsavar for RPS20 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs4576403 -- 56,069,525(+) aactc(C/G)tgacc intron-variant
rs2953897 -- 56,068,010(+) AGATA(C/T)TAGAA downstream-variant-500B
rs2953898 -- 56,068,244(+) CAATA(C/T)AAGTG utr-variant-3-prime
rs2953900 -- 56,069,765(-) GTATT(C/T)GAATC reference, synonymous-codon
rs2953901 -- 56,069,265(-) ACTCA(G/T)TCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPS20 Gene

Variant ID Type Subtype PubMed ID
nsv831319 CNV Gain 17160897
nsv524526 CNV Loss 19592680
nsv525972 CNV Loss 19592680

Variation tolerance for RPS20 Gene

Residual Variation Intolerance Score: 53.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS20 Gene

HapMap Linkage Disequilibrium report
RPS20
Human Gene Mutation Database (HGMD)
RPS20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS20 Gene

Disorders for RPS20 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPS20 Gene - From: Orphanet

Disorder Aliases PubMed IDs
familial colorectal cancer type x
  • fcctx
- elite association - COSMIC cancer census association via MalaCards
Search RPS20 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RPS20

Genetic Association Database (GAD)
RPS20
Human Genome Epidemiology (HuGE) Navigator
RPS20
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPS20
genes like me logo Genes that share disorders with RPS20: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS20 Gene

Publications for RPS20 Gene

  1. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3 4 67
  2. HDM2-binding partners: interaction with translation elongation factor EF1alpha. (PMID: 17373842) Frum R. … Deb S.P. (J. Proteome Res. 2007) 3 23
  3. Medulloblastoma outcome is adversely associated with overexpression of EEF1D, RPL30, and RPS20 on the long arm of chromosome 8. (PMID: 16968546) De Bortoli M. … Kim J.Y. (BMC Cancer 2006) 3 23
  4. Human ribosomal protein S20 cDNA sequence. (PMID: 8479924) Chu W. … Burns D.K. (Nucleic Acids Res. 1993) 2 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for RPS20 Gene

Sources for RPS20 Gene

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