Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RPS20 Gene

protein-coding GIFtS: 59
GCID: GC08M056982

ribosomal protein S20

Explore 8 diseases affiliated with
RPS20 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ribosomal Protein S20¹ ²
S20¹ ²
40S Ribosomal Protein S20²

External Ids:	HGNC: 10405¹	Entrez Gene: 6224²	Ensembl: ENSG00000008988⁷	OMIM: 603682⁵	UniProtKB: P60866³

Export aliases for RPS20 gene to outside databases

Previous GC identifers: GC08M056164 GC08M056924 GC08M056704 GC08M057035 GC08M057148

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RPS20:

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.

Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene

encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S10P family of

ribosomal proteins. It is located in the cytoplasm. This gene is co-transcribed with the small nucleolar RNA gene U54,

which is located in its second intron. As is typical for genes encoding ribosomal proteins, there are multiple

processed pseudogenes of this gene dispersed through the genome. Two transcript variants encoding different isoforms

have been identified for this gene. (provided by RefSeq, Apr 2009)

Gene Wiki entry for RPS20

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_008183.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RPS20 gene promoter:
ISGF-3 AP-1 p53 Ik-3 AP-2gamma RORalpha2 c-Ets-1 AP-2beta AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RPS20 promoter sequence

Search SABiosciences Chromatin IP Primers for RPS20

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS20

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q12 Ensembl cytogenetic band: 8q12.1 HGNC cytogenetic band: 8q12.1

RPS20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS20 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M056982: view genomic region (about GC identifiers)

Start:	56,979,854 bp from pter	End:	56,987,140 bp from pter
Size:	7,287 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RS20_HUMAN, P60866 (See protein sequence)

Recommended Name: 40S ribosomal protein S20

Size: 119 amino acids; 13373 Da

Subunit: Component of the 40S small ribosomal subunit (By similarity)

Subcellular location: Cytoplasm (By similarity)

Secondary accessions: B2R4F4 B4DW28 P17075 Q5M8S9

Alternative splicing: 2 isoforms: P60866-1 P60866-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RPS20: NX_P60866

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P60866

RPS20 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001014.1 NP_001139699.1

ENSEMBL proteins:

ENSP00000429374 ENSP00000009589 ENSP00000429049 ENSP00000427788 ENSP00000427860

ENSP00000428104 ENSP00000429333 ENSP00000428146

Reactome Protein details: P60866
Human Recombinant Protein Products for RPS20:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: RPS20 OriGene Protein Over-expression Lysate: RPS20 OriGene Custom Protein Services for RPS20
	GenScript Custom Purified and Recombinant Proteins Services for RPS20
	Novus Biologicals RPS20 Proteins Novus Biologicals RPS20 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for RPS20

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	--
GO:0005829	cytosol	TAS	--
GO:0005840	ribosome	--	--
GO:0015935	small ribosomal subunit	--	--
GO:0022627	cytosolic small ribosomal subunit	IDA	8706699

RPS20 for ontologies About GeneDecksing

RPS20 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies: RPS20 OriGene Custom Antibody Services for RPS20
	GenScript Custom Superior Antibodies Services for RPS20
	Novus Biologicals RPS20 Antibodies
	Abcam antibodies for RPS20
	Uscn Antibodies for RPS20
	Search ThermoFisher Antibodies for RPS20

Assay Products for RPS20:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RPS20
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for RPS20

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RPS20 for domains About GeneDecksing

3 InterPro domains/families:

IPR001848 Ribosomal_S10

IPR018268 Ribosomal_S10_CS

IPR005729 Ribosomal_S10_euk/arc

Graphical View of Domain Structure for InterPro Entry P60866

ProtoNet protein and cluster: P60866

UniProtKB/Swiss-Prot: RS20_HUMAN, P60866

Similarity: Belongs to the ribosomal protein S10P family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

Genatlas biochemistry entry for RPS20:

40S ribosomal protein S20

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003723	RNA binding	NAS	8479924
GO:0003735	structural constituent of ribosome	NAS	8479924

RPS20 for ontologies About GeneDecksing

Phenotypes:
8 GenomeRNAi human phenotypes for RPS20:

Cytoplasmic 40S maturation def	Decreased Hepatitis C virus re	Decreased cell number, increas	Decreased nuclei size in G2M
Decreased viability of wild-ty	Increased number of mitotic ce	Nucleolar pre-40S maturation d	S arrest

4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Rps20):

integument

limbs/digits/tail

mortality/aging

pigmentation

RPS20 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RPS20

miRNA Products:		OriGene 3'-UTR Clone (see all 2): RPS20 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPS20
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate RPS20
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPS20 (see all 7) OriGene shRNA RFP: RPS20 OriGene siRNA: RPS20
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS20
		Sirion Biotech Custom design and validation of potent shRNA sequences against RPS20

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for RPS20
			Sirion Biotech Customized adenovirus for overexpression of RPS20 Sirion Biotech Customized adenovirus for potent knockdown of RPS20

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPS20 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPS20 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): RPS20 (NM_001023)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPS20
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS20

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RPS20
		Search LifeMap BioReagents cell lines for RPS20
		Sirion Biotech Customized stable knockdown cell line services for RPS20 Sirion Biotech Customized inducible knockdown cell line services for RPS20 Sirion Biotech Customized stable overexpressing cell line services for RPS20 Sirion Biotech Customized inducible overexpressing cell line services for RPS20

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RPS20

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Synthesis of PB1-F2

8/26 pathways (see all 26)
Viral Protein Synthesis	1.00	Cytoplasmic Ribosomal Proteins	0.86
Viral mRNA Translation	1.00	CFTR translational fidelity (class I mutations)	0.83
Influenza Viral RNA Transcription and Replication	1.00	SMG6 Cleaves mRNA with Premature Termination Codon	0.80
Synthesis of nascent polypeptide containing signal sequence	1.00	L13a-mediated translational silencing of Ceruloplasmin expression	0.79

Translation initiation complex formation

	Translation initiation complex formation	1.00			Ribosomal scanning and start codon recognition	0.96
	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	0.98			Formation of the ternary complex, and subsequently, the 43S complex	0.87

Metabolism of mRNA

Metabolism of mRNA

1.00

Metabolism of RNA

0.92

Disease

Disease

1.00

Generic Transcription Pathway

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

1 GeneGo (Thomson Reuters) Pathway for RPS20

CFTR translational fidelity (class I mutations)

1 BioSystems Pathway for RPS20

Cytoplasmic Ribosomal Proteins

5/32 Reactome Pathways for RPS20 (see all 32)

	Formation of a pool of free 40S subunits
	Synthesis of PB1-F2
	SMG6 Cleaves mRNA with Premature Termination Codon
	Influenza Life Cycle
	Viral mRNA Translation

1 Kegg Pathway (Kegg details for RPS20):

Ribosome

RPS20 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RPS20

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/439 Interacting proteins for RPS20 (P60866^{2, 3} ENSP00000009589⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 439)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RPL23	P62829²^,³, ENSP00000377865⁴	MINT-6542674 MINT-6489217 MINT-6489539 I2D: score=2 STRING: ENSP00000377865
RPS26	P62854²^,³, ENSP00000348849⁴	MINT-6542674 MINT-6489539 MINT-8044024 I2D: score=1 STRING: ENSP00000348849
RPS3	P23396²^,³, ENSP00000278572⁴	MINT-6542674 MINT-6489539 I2D: score=5 STRING: ENSP00000278572
RPS15A	P62244²^,³, ENSP00000318646⁴	MINT-6542674 MINT-6489539 I2D: score=4 STRING: ENSP00000318646
RPL11	P62913²^,³, ENSP00000363676⁴	MINT-6542674 MINT-6489539 I2D: score=3 STRING: ENSP00000363676

About this table

Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS	--
GO:0006412	translation	TAS	--
GO:0006413	translational initiation	TAS	--
GO:0006414	translational elongation	TAS	--
GO:0006415	translational termination	TAS	--

RPS20 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RPS20
Search CenterWatch for drugs/clinical trials and news about RPS20 / RS20

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RPS20 gene (2 alternative transcripts):

NM_001023.3 NM_001146227.1

Unigene Cluster for RPS20:

Ribosomal protein S20

Hs.8102 [show with all ESTs]

Unigene Representative Sequence: BQ053882

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000519807(uc003xsm.2) ENST00000009589(uc003xsn.2) ENST00000524349

ENST00000520490 ENST00000521262 ENST00000520627 ENST00000523936 ENST00000519606

ENST00000521289 ENST00000518875 ENST00000519369

miRNA Products:		OriGene 3'-UTR Clone (see all 2): RPS20 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPS20
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate RPS20
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPS20 (see all 7) OriGene shRNA RFP: RPS20 OriGene siRNA: RPS20
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS20
		Sirion Biotech Custom design and validation of potent shRNA sequences against RPS20

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPS20 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPS20 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): RPS20 (NM_001023)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPS20
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS20

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPS20 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat RPS20
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS20
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS20

Additional cDNA sequence:

AK130961.1 AK301342.1 AK311808.1 BC007507.2 BC087850.1 D28358.1 L06498.1

24/94 DOTS entries (see all 94):

DT.100741479 DT.98083175 DT.75120818 DT.100741514 DT.91867386 DT.91949530 DT.100855793 DT.91784069

DT.95210310 DT.91964648 DT.121470087 DT.100893924 DT.92045974 DT.100851177 DT.91784086 DT.91801971

DT.100741495 DT.91995465 DT.121469955 DT.99926488 DT.101956696 DT.121470098 DT.121470090 DT.100741492

24/2784 AceView cDNA sequences (see all 2784):

AA086151 T93315 CB135984 AA315089 CB118949 BM704126 BM838636 AA380060

BM760662 BM852095 BE206349 AV660572 BU154649 BU153590 BE265294 AA865986

CB110095 BU730022 AA160495 BM988512 AI357773 CB140319 H23739 BQ060056

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RPS20 (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	·	4c
SP1:											-								-
SP2:											-						-		-
SP3:																			-
SP4:											-
SP5:

ECgene alternative splicing isoforms for RPS20

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RPS20 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTTTTAAGG

About this image

RPS20 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Primary Follicle

Primary Oocyte

Female Gametocytes, Germ Cells

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RPS20 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RPS20

SOURCE GeneReport for Unigene cluster: Hs.8102

SABiosciences Custom PCR Arrays for RPS20

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPS20 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat RPS20
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS20
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS20

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RPS20

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for RPS20 gene from 9/38 species (see all 38) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rps20⁵	ribosomal protein S20	--		4 (2.14 cM) 3831334
chicken (Gallus gallus)	Aves	RPS20⁶	Uncharacterized protein	92(a)	1 ↔ 1	2(114876693-114883844)
African clawed frog (Xenopus laevis)	Amphibia	Xl.1787²	Xenopus laevis transcribed sequence with strong similarity more	81.61(n)		CB941110.1
zebrafish (Danio rerio)	Actinopterygii	Dr.280²	Danio rerio cDNA clone MGC77758 IMAGE7000995, complete more	80.54(n)		BC062282.1
fruit fly (Drosophila melanogaster)	Insecta	RpS20³	protein biosynthesis structural constituent of more	81(a)		93A1 --
worm (Caenorhabditis elegans)	Secernentea	Y105E8A.16³	--	80(a)		I(14476520-14477058) --
thale cress (Arabidopsis thaliana)	eudicotyledons	AT5G62300⁶ AT3G45030⁶ (see all 4)	40S ribosomal protein S20-1 (see all 4)	65(a) 65(a) (see all 4)	many → 1 many → 1 (see all 4)	5(25021200-25022436) 3(16471386-16472393)
rice (Oryza sativa)	Liliopsida	AK062184.1²	--	72.65(n)		AK062184.1
E. coli (Escherichia coli)	Gamma proteobacteria	rpsJ⁶	30S ribosomal subunit protein S10	24(a)	1 ↔ 1	Chromosome(3450981-3451292)

ENSEMBL Gene Tree for RPS20 (if available)
TreeFam Gene Tree for RPS20 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RPS20 gene

RPS20 for paralogs About GeneDecksing

5/37 Pseudogenes.org Pseudogenes for RPS20 (see all 37)
PGOHUM00000242223 PGOHUM00000242376 PGOHUM00000239311 PGOHUM00000239612 PGOHUM00000239639

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs142278807^1,2	C	other	56985818(+)	`TTGTAG/ATGATT`	4	/T /I	mis¹		1		NA	3370
rs187507813^1,2		--	56980280(+)	`ATGATA/GTGGTA`	1	--	ds500¹		0	--	--	--	--
rs7812337^1,2	C,F,H	--	56980480(+)	`aagacA/Gaaaga`	1	--	ds500¹		5		NS EA WA	536
rs73592339^1,2	C	--	56980528(+)	`TAATGC/TTACAG`	1	--	ds500¹		1		WA	2
rs138342615^1,2	C	--	56980540(+)	`CTGTT-/AAGAAA`	1	--	ds500¹		0	--	--	--	--
rs2976009^1,2	C,F,H	--	56980542(-)	`cttttC/Ttaaca`	1	--	ds500¹		10		NS EA WA NA CSA	428
rs2953897^1,2	C,F	--	56980569(+)	`AGATAC/TTAGAA`	1	--	ds500¹		1		NA	120
rs151271827^1,2	C	--	56980644(+)	`TTGTT-/GGGAGT`	1	--	ds500¹		0	--	--	--	--
rs185518377^1,2		--	56980665(+)	`ATAAAA/GCTGGT`	1	--	ds500¹		0	--	--	--	--
rs190827927^1,2		--	56980679(+)	`AGTTGA/GCAATC`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for RPS20 (56979854 - 56987140 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RPS20: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPS20

DNA2.0 Custom Variant and Variant Library Synthesis for RPS20

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RPS20 for disorders           About GeneDecksing

OMIM gene information: 603682    OMIM disorders: --

8 diseases for RPS20:    About MalaCards

intrahepatic cholangiocarcinoma cholangiocarcinoma medulloblastoma influenza

prostate cancer retinitis prostatitis malaria

1 Novoseek disease relationship for RPS20 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	1	17373842 (1)

Human Genome Epidemiology (HuGE) Navigator: RPS20 (1 document)

Export disorders for RPS20 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RPS20 gene, integrated from 9 sources (see all 59):
(articles sorted by number of sources associating them with RPS20)

Utopia: connect your pdf to the dynamic
world of online information

A map of 75 human ribosomal protein genes. (PubMed id 9582194)^{1, 2, 3} Kenmochi N.... Page D.C. (1998)
Human ribosomal protein S20 cDNA sequence. (PubMed id 8479924)^{1, 2, 3} Chu W.... Burns D.K. (1993)
Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PubMed id 18781797)^{1, 2} Meierhofer D.... Kaiser P. (2008)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PubMed id 11875025)^{1, 2} Yoshihama M.... Kenmochi N. (2002)
Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699)^{1, 2} Vladimirov S.N.... Otto A. (1996)
Medulloblastoma outcome is adversely associated with overexpression of EEF1D, RPL30, and RPS20 on the long arm of chromosome 8. (PubMed id 16968546)^{1, 9} De Bortoli M....Kim J.Y. (2006)
HDM2-binding partners: interaction with translation elongation factor EF1alpha. (PubMed id 17373842)^{1, 9} Frum R....Deb S.P. (2007)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)¹ Woods N.T....Monteiro A.N. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6224	HGNC: 10405	AceView: RPS20	Ensembl:ENSG00000008988	euGenes: HUgn6224
ECgene: RPS20	Kegg: 6224	H-InvDB: RPS20

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RPS20	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RPS20 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RPS20 gene:
Search GeneIP for patents involving RPS20

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for RPS20		OriGene shRNA RFP for RPS20
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPS20		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPS20
	OriGene Protein Over-expression Lysate for RPS20		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for RPS20		OriGene 3'-UTR Clone for RPS20
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPS20		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPS20
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for RPS20		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for RPS20		OriGene Custom Protein Services for RPS20
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RPS20
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPS20
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS20
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS20
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS20
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS20

	GenScript Custom Purified and Recombinant Proteins Services for RPS20		GenScript cDNA clones with any tag delivered in your preferred vector for RPS20
	GenScript Custom Assay Services for RPS20		GenScript Custom Superior Antibodies Services for RPS20
	GenScript Custom overexpressing Cell Line Services for RPS20		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in RPS20 promoter
	Search Chromatin IP Primers for RPS20
	RT² qPCR Primer Assay in human, mouse / rat RPS20
	GNC Network for RPS20
	SABiosciences Custom PCR Arrays for RPS20

Search Tocris compounds for RPS20

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	RPS20 antibodies
	RPS20 proteins
	RPS20 lysates

	Antibodies for RPS20
	See all of Abcam's Antibodies, Kits and Proteins for RPS20
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

RPS20 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for RPS20

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RPS20

	Browse SwitchGear 3'UTR luciferase reporter plasmids for RPS20
	SwitchGear Promoter luciferase reporter plasmids for RPS20

Search ThermoFisher Antibodies for RPS20

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS20

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RPS20

Sirion Biotech Customized:

	stable knockdown cell line services for RPS20
	inducible knockdown cell line services for RPS20
	design and validation of potent shRNA sequences against RPS20
	adenovirus for potent knockdown of RPS20
	adenovirus for overexpression of RPS20
	stable overexpressing cell line services for RPS20
	inducible overexpressing cell line services for RPS20

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes RPS20 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

RPS20 Gene

ribosomal protein S20

Aliases
for RPS20 gene

Summaries
for RPS20 gene

Genomic Views
for RPS20 gene

Proteins
for RPS20 gene

Protein Domains /
Families
for RPS20 gene

Function
for RPS20 gene

Pathways & Interactions
for RPS20 gene

Drugs & Compounds
for RPS20 gene

Transcripts
for RPS20 gene

Expression
for RPS20 gene

Orthologs
for RPS20 gene

Paralogs
for RPS20 gene

Genomic Variants
for RPS20 gene

Disorders / Diseases
for RPS20 gene

Publications
for RPS20 gene

External Searches for RPS20 gene

Genome Databases showing RPS20 gene

Other Databases showing RPS20 gene

Specialized Databases showing RPS20 gene

Intellectual Property
for RPS20 gene

Products
for RPS20 gene

View Random Gene

Advanced Search

Export list of displayed genes

RPS20 Gene

ribosomal protein S20

Aliasesfor RPS20 gene

Summariesfor RPS20 gene

Genomic Viewsfor RPS20 gene

Proteinsfor RPS20 gene

Protein Domains /Familiesfor RPS20 gene

Functionfor RPS20 gene

Pathways & Interactionsfor RPS20 gene

Drugs & Compoundsfor RPS20 gene

Transcriptsfor RPS20 gene

Expression for RPS20 gene

Orthologsfor RPS20 gene

Paralogsfor RPS20 gene

Genomic Variantsfor RPS20 gene

Disorders / Diseasesfor RPS20 gene

Publicationsfor RPS20 gene

External Searches for RPS20 gene

Genome Databases showing RPS20 gene

Other Databases showing RPS20 gene

Specialized Databases showing RPS20 gene

Intellectual Propertyfor RPS20 gene

Productsfor RPS20 gene

View Random Gene

Aliases
for RPS20 gene

Summaries
for RPS20 gene

Genomic Views
for RPS20 gene

Proteins
for RPS20 gene

Protein Domains /
Families
for RPS20 gene

Function
for RPS20 gene

Pathways & Interactions
for RPS20 gene

Drugs & Compounds
for RPS20 gene

Transcripts
for RPS20 gene

Expression
for RPS20 gene

Orthologs
for RPS20 gene

Paralogs
for RPS20 gene

Genomic Variants
for RPS20 gene

Disorders / Diseases
for RPS20 gene

Publications
for RPS20 gene

Intellectual Property
for RPS20 gene

Products
for RPS20 gene