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Aliases for RPS20 Gene

Aliases for RPS20 Gene

  • Ribosomal Protein S20 2 3 5
  • 40S Ribosomal Protein S20 3
  • S20 3

External Ids for RPS20 Gene

Previous GeneCards Identifiers for RPS20 Gene

  • GC08M056164
  • GC08M056924
  • GC08M056704
  • GC08M057035
  • GC08M057148
  • GC08M056982

Summaries for RPS20 Gene

Entrez Gene Summary for RPS20 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S10P family of ribosomal proteins. It is located in the cytoplasm. This gene is co-transcribed with the small nucleolar RNA gene U54, which is located in its second intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Apr 2009]

GeneCards Summary for RPS20 Gene

RPS20 (Ribosomal Protein S20) is a Protein Coding gene. Diseases associated with RPS20 include Familial Colorectal Cancer Type X. Among its related pathways are Viral mRNA Translation and Transport to the Golgi and subsequent modification. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPS20 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS20 Gene

Genomics for RPS20 Gene

Regulatory Elements for RPS20 Gene

Enhancers for RPS20 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around RPS20 on UCSC Golden Path with GeneCards custom track

Promoters for RPS20 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for RPS20 Gene

56,067,295 bp from pter
56,074,581 bp from pter
7,287 bases
Minus strand

Genomic View for RPS20 Gene

Genes around RPS20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS20 Gene

Proteins for RPS20 Gene

  • Protein details for RPS20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    40S ribosomal protein S20
    Protein Accession:
    Secondary Accessions:
    • B2R4F4
    • B4DW28
    • P17075
    • Q5M8S9

    Protein attributes for RPS20 Gene

    119 amino acids
    Molecular mass:
    13373 Da
    Quaternary structure:
    • Component of the 40S small ribosomal subunit.

    Three dimensional structures from OCA and Proteopedia for RPS20 Gene

    Alternative splice isoforms for RPS20 Gene


neXtProt entry for RPS20 Gene

Post-translational modifications for RPS20 Gene

  • Ubiquitination at Lys 30, Lys 34, Lys 67, and Lys 75
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPS20 Gene

Domains & Families for RPS20 Gene

Gene Families for RPS20 Gene

Protein Domains for RPS20 Gene

Suggested Antigen Peptide Sequences for RPS20 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein S10P family.
  • Belongs to the ribosomal protein S10P family.
genes like me logo Genes that share domains with RPS20: view

Function for RPS20 Gene

Molecular function for RPS20 Gene

GENATLAS Biochemistry:
40S ribosomal protein S20

Gene Ontology (GO) - Molecular Function for RPS20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 8479924
GO:0005515 protein binding IPI 18274552
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPS20: view
genes like me logo Genes that share phenotypes with RPS20: view

Human Phenotype Ontology for RPS20 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for RPS20 Gene

miRTarBase miRNAs that target RPS20

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS20 Gene

Localization for RPS20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS20 Gene


Subcellular locations from

Jensen Localization Image for RPS20 Gene COMPARTMENTS Subcellular localization image for RPS20 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 2
plasma membrane 2
chloroplast 1
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPS20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
GO:0022627 cytosolic small ribosomal subunit IDA 8706699
genes like me logo Genes that share ontologies with RPS20: view

Pathways & Interactions for RPS20 Gene

SuperPathways for RPS20 Gene

Superpath Contained pathways
1 Viral mRNA Translation
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 Infectious disease
5 rRNA processing
genes like me logo Genes that share pathways with RPS20: view

Gene Ontology (GO) - Biological Process for RPS20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation NAS 8479924
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPS20: view

No data available for SIGNOR curated interactions for RPS20 Gene

Drugs & Compounds for RPS20 Gene

No Compound Related Data Available

Transcripts for RPS20 Gene

Unigene Clusters for RPS20 Gene

Ribosomal protein S20:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS20 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c
SP1: - -
SP2: - - -
SP3: -
SP4: -
SP6: - - - -

Relevant External Links for RPS20 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS20 Gene

mRNA expression in normal human tissues for RPS20 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPS20 Gene

Protein tissue co-expression partners for RPS20 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS20 Gene:


SOURCE GeneReport for Unigene cluster for RPS20 Gene:

genes like me logo Genes that share expression patterns with RPS20: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS20 Gene

Orthologs for RPS20 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS20 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPS20 34
  • 88.8 (n)
  • 100 (a)
RPS20 35
  • 96 (a)
(Canis familiaris)
Mammalia RPS20 34
  • 90.48 (n)
  • 100 (a)
-- 35
  • 77 (a)
-- 35
  • 58 (a)
-- 35
  • 96 (a)
(Mus musculus)
Mammalia Rps20 34
  • 89.64 (n)
  • 100 (a)
Rps20 16
Rps20 35
  • 96 (a)
(Pan troglodytes)
Mammalia RPS20 34
  • 100 (n)
  • 100 (a)
RPS20 35
  • 99 (a)
(Rattus norvegicus)
Mammalia Rps20 34
  • 89.64 (n)
  • 100 (a)
(Monodelphis domestica)
Mammalia RPS20 35
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia RPS20 35
  • 95 (a)
(Gallus gallus)
Aves RPS20 34
  • 82.63 (n)
  • 98.32 (a)
RPS20 35
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rbm6 34
  • 79.27 (n)
  • 96.64 (a)
Str.17075 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.1787 34
(Danio rerio)
Actinopterygii Dr.280 34
rps20 34
  • 79.83 (n)
  • 97.48 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10529 34
fruit fly
(Drosophila melanogaster)
Insecta RpS20 36
  • 81 (a)
RpS20 34
  • 69.23 (n)
  • 81.2 (a)
RpS20 35
  • 77 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010591 34
  • 67.52 (n)
  • 82.91 (a)
(Caenorhabditis elegans)
Secernentea Y105E8A.16 36
  • 80 (a)
rps-20 34
  • 66.01 (n)
  • 80.2 (a)
rps-20 35
  • 71 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR041C 34
  • 58.79 (n)
  • 54.55 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F25542g 34
  • 61.52 (n)
  • 62.73 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS20 34
  • 64.03 (n)
  • 62.38 (a)
RPS20 35
  • 51 (a)
RPS20 37
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G62300 34
  • 68.21 (n)
  • 74.07 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.767 34
(Hordeum vulgare)
Liliopsida Hv.3696 34
(Oryza sativa)
Liliopsida Os06g0134000 34
  • 66.67 (n)
  • 76.24 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6589 34
bread mold
(Neurospora crassa)
Ascomycetes NCU06892 34
  • 65.74 (n)
  • 72.22 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps20 34
  • 71.57 (n)
  • 80.39 (a)
Species where no ortholog for RPS20 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS20 Gene

Gene Tree for RPS20 (if available)
Gene Tree for RPS20 (if available)

Paralogs for RPS20 Gene

genes like me logo Genes that share paralogs with RPS20: view

No data available for Paralogs for RPS20 Gene

Variants for RPS20 Gene

Sequence variations from dbSNP and Humsavar for RPS20 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2953897 -- 56,068,010(+) AGATA(C/T)TAGAA downstream-variant-500B
rs2953898 -- 56,068,244(+) CAATA(C/T)AAGTG utr-variant-3-prime
rs2953900 -- 56,069,765(-) GTATT(C/T)GAATC reference, synonymous-codon
rs2953901 -- 56,069,265(-) ACTCA(G/T)TCTCA intron-variant
rs2953916 -- 56,071,833(-) TTTGA(A/G)ATTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPS20 Gene

Variant ID Type Subtype PubMed ID
nsv524526 CNV loss 19592680
nsv525972 CNV loss 19592680
nsv831319 CNV gain 17160897
nsv967592 CNV duplication 23825009

Variation tolerance for RPS20 Gene

Residual Variation Intolerance Score: 53.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS20 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS20 Gene

Disorders for RPS20 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPS20 Gene - From: Orphanet

Disorder Aliases PubMed IDs
familial colorectal cancer type x
  • fcctx
- elite association - COSMIC cancer census association via MalaCards
Search RPS20 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RPS20

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RPS20: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS20 Gene

Publications for RPS20 Gene

  1. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3 4 65
  2. Human ribosomal protein S20 cDNA sequence. (PMID: 8479924) Chu W. … Burns D.K. (Nucleic Acids Res. 1993) 2 3 4 65
  3. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J. … Grant S.F. (BMC Med. Genet. 2010) 3 46 65
  4. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 46 65
  5. HDM2-binding partners: interaction with translation elongation factor EF1alpha. (PMID: 17373842) Frum R. … Deb S.P. (J. Proteome Res. 2007) 3 22 65

Products for RPS20 Gene

Sources for RPS20 Gene

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