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RPS2 Gene

protein-coding   GIFtS: 64
GCID: GC16M002012

Ribosomal Protein S2

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribosomal Protein S21 2     LLREP32
Protein LLRep32 3     OK/KNS-cl.62
40S Ribosomal Protein S42 3     S22
40S Ribosomal Protein S22     RPS43

External Ids:    HGNC: 104041   Entrez Gene: 61872   Ensembl: ENSG000001409887   OMIM: 6036245   UniProtKB: P158803   

Export aliases for RPS2 gene to outside databases

Previous GC identifers: GC16M002029 GC16M001952


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RPS2 Gene:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This
gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S5P family of
ribosomal proteins. It is located in the cytoplasm. This gene shares sequence similarity with mouse LLRep3. It is
co-transcribed with the small nucleolar RNA gene U64, which is located in its third intron. As is typical for
genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the
genome. (provided by RefSeq, Jul 2008)

GeneCards Summary for RPS2 Gene:
RPS2 (ribosomal protein S2) is a protein-coding gene. Diseases associated with RPS2 include diamond-blackfan anemia, and herpes simplex. GO annotations related to this gene include fibroblast growth factor binding and RNA binding.

Gene Wiki entry for RPS2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_010393.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPS2 gene promoter:
         SRF   NF-1   NF-1/L   AML1a   MAZR   Pax-5   SRF (504 AA)   AP-4   YY1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPS2 promoter sequence
   Search Chromatin IP Primers for RPS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

RPS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M002012:  view genomic region     (about GC identifiers)

Start:
2,012,053 bp from pter      End:
2,014,861 bp from pter
Size:
2,809 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RS2_HUMAN, P15880 (See protein sequence)
Recommended Name: 40S ribosomal protein S2  
Size: 293 amino acids; 31324 Da
Sequence caution: Sequence=CAA35078.1; Type=Frameshift; Positions=14, 27, 40, 46, 48, 52;
1 PDB 3D structure from and Proteopedia for RPS2:
3J3A (3D)    
Secondary accessions: B2R5G0 D3DU82 Q3MIB1

Explore the universe of human proteins at neXtProt for RPS2: NX_P15880

Explore proteomics data for RPS2 at MOPED

Post-translational modifications: 

  • Citrullinated by PADI4 in the Arg/Gly-rich region1
  • Asymmetric arginine dimethylation by PRMT3 occurs at multiple sites in the Arg/Gly-rich region1
  • Ubiquitination2 at Lys58, Lys65, Lys76, Lys108, Lys114, Lys145, Lys212, Lys238, Lys246, Lys257,
                                 Lys263, Lys275
  • Modification sites at PhosphoSitePlus

  • See RPS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002943.2  
    ENSEMBL proteins: 
     ENSP00000341885   ENSP00000436865   ENSP00000460860   ENSP00000436227   ENSP00000434846  
     ENSP00000436356   ENSP00000433170   ENSP00000433034   ENSP00000454837  
    Reactome Protein details: P15880

    RPS2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RPS: S ribosomal proteins

    Selected InterPro protein domains (see all 8):
     IPR005711 Ribosomal_S5_euk/arc
     IPR013810 Ribosomal_S5_N
     IPR014720 dsRNA-bd_dom
     IPR005324 Ribosomal_S5_C
     IPR020568 Ribosomal_S5_D2-typ_fold

    Graphical View of Domain Structure for InterPro Entry P15880

    ProtoNet protein and cluster: P15880

    2 Blocks protein domains:
    IPB000851 Ribosomal protein S5
    IPB011070 Globular protein


    UniProtKB/Swiss-Prot: RS2_HUMAN, P15880
    Similarity: Belongs to the ribosomal protein S5P family
    Similarity: Contains 1 S5 DRBM domain


    RPS2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for RPS2:
    60S ribosomal protein S2

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding ----
    GO:0003729mRNA binding IDA18464793
    GO:0003735structural constituent of ribosome IDA15883184
    GO:0005515protein binding IPI15473865
    GO:0017134fibroblast growth factor binding IPI16263090
         
    RPS2 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for RPS2:
     Cytoplasmic 40S maturation def  Decreased G3BP1 protein expres  Decreased Hepatitis C virus re  Increased cell death HMECs cel 
     Increased cell number in S  Increased gamma-H2AX phosphory 

    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target RPS2:
    hsa-mir-1250-5p (MIRT035864), hsa-mir-196a-5p (MIRT048173), hsa-mir-361-5p (MIRT044087), hsa-mir-186-5p (MIRT045205), hsa-mir-361-3p (MIRT038274), hsa-mir-423-5p (MIRT038055), hsa-mir-222-3p (MIRT046672), hsa-mir-34a-5p (MIRT047364), hsa-mir-324-5p (MIRT043030), hsa-mir-760 (MIRT036761), hsa-mir-1301-3p (MIRT036012), hsa-mir-25-5p (MIRT038957), hsa-mir-455-3p (MIRT037900), hsa-mir-18a-3p (MIRT040839), hsa-mir-615-3p (MIRT040163), hsa-mir-16-5p (MIRT031671), hsa-mir-125a-5p (MIRT045736), hsa-mir-940 (MIRT036604), hsa-mir-330-3p (MIRT043827), hsa-mir-3943 (MIRT052895), hsa-mir-99b-5p (MIRT044194), hsa-mir-423-3p (MIRT042586), hsa-mir-328-3p (MIRT043802), hsa-mir-22-3p (MIRT050452), hsa-mir-331-3p (MIRT043266)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5
    chloroplast2
    mitochondrion2
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm IDA16061210
    GO:0005730NOT nucleolus IDA16061210
    GO:0005829cytosol TAS--
    GO:0005840ribosome ----
    GO:0015935small ribosomal subunit ----

    RPS2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RPS2 About   (see all 6)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CFTR translational fidelity class I mutations
    CFTR translational fidelity class I mutations 0.60
    Ribosome0.54
    Cytoplasmic Ribosomal Proteins0.60
    2Influenza Viral RNA Transcription and Replication
    Viral mRNA Translation0.94
    Eukaryotic Translation Initiation0.89
    Peptide chain elongation0.94
    Cap-dependent Translation Initiation0.89
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    Formation of a pool of free 40S subunits0.94
    Nonsense-Mediated Decay0.89
    3Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
    Translation initiation complex formation0.91
    Ribosomal scanning and start codon recognition0.91
    Formation of the ternary complex, and subsequently, the 43S complex0.91
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.90
    4Gene Expression
    Gene Expression0.40
    5Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPS2
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPS2
        Cytoplasmic Ribosomal Proteins


    Selected Reactome Pathways for RPS2 (see all 12)
        Peptide chain elongation
    Formation of the ternary complex, and subsequently, the 43S complex
    Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
    Viral mRNA Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit


    1 Kegg Pathway  (Kegg details for RPS2):
        Ribosome


    RPS2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RPS2
    Interactions:

        GeneGlobe Interaction Network for RPS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPS2 (P158802, 3 ENSP000003418854) via UniProtKB, MINT, STRING, and/or I2D (see all 493)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPS15AP622442, 3, ENSP000003186464MINT-6542674 MINT-6489539 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=4 STRING: ENSP00000318646
    RPL11P629132, 3, ENSP000003636764MINT-6542674 MINT-6489539 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=3 STRING: ENSP00000363676
    RPS3P233962, 3, ENSP000002785724MINT-6542674 MINT-6489539 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=3 STRING: ENSP00000278572
    RPL26P612542, 3MINT-6542674 MINT-6489539 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=2 
    RPL27AP467762, 3, ENSP000003460154MINT-6489539 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=2 STRING: ENSP00000346015
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--
    GO:0006415translational termination TAS--

    RPS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPS2 (RS2)

    1 Novoseek inferred chemical compound relationship for RPS2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arginine 34.9 1 15473865 (1)



    RPS2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RPS2 gene: 
    NM_002952.3  

    Unigene Clusters for RPS2:

    Ribosomal protein S2
    Hs.356366  [show with all ESTs], Hs.381079  [show with all ESTs], Hs.498569  [show with all ESTs], Hs.506997  [show with all ESTs]
    Unigene Representative Sequences: BG165653, BM467031, BF972117, BM423570
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000343262(uc002cno.2) ENST00000526522 ENST00000526586 ENST00000533186
    ENST00000532746 ENST00000533872 ENST00000527109(uc002cnm.2) ENST00000527871
    ENST00000530225 ENST00000531065 ENST00000533161(uc002cnn.2) ENST00000529806
    ENST00000534461 ENST00000527302 ENST00000526908 ENST00000527826 ENST00000563194

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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      QuantiFast Probe-based Assays in human, mouse, rat RPS2

    Additional mRNA sequence: 

    AB082925.1 AL832857.1 BC001795.1 BC006559.2 BC008329.2 BC008862.2 BC010165.2 BC012354.1 
    BC013833.1 BC016178.1 BC016951.2 BC018993.2 BC019021.2 BC021545.1 BC023541.1 BC025677.1 
    BC029979.1 BC032129.2 BC035427.1 BC066321.1 BC068051.1 BC071673.1 BC071922.1 BC071923.1 
    BC071924.1 BC073966.1 BC075830.1 BC105985.1 BC106060.1 

    Selected DOTS entries (see all 346):

    DT.95277449  DT.100640089  DT.100763615  DT.95277540  DT.100737773  DT.92411543  DT.100737906  DT.100737854 
    DT.100737763  DT.91940355  DT.97849492  DT.99926730  DT.100846786  DT.75177498  DT.92473920  DT.87010305 
    DT.97869804  DT.92473980  DT.99926712  DT.100737891  DT.92474003  DT.120702433  DT.97869788  DT.100737858 

    Selected AceView cDNA sequences (see all 260):

    CR620130 CR605226 CR606602 CR624847 CR612811 BG876857 CR596231 CR607612 
    CR607006 CR622407 AI971893 CR609604 AB065089 CR608202 BC004520 BC063011 
    CR617837 CN484452 CR601170 CR613584 CR593005 CR607747 Y11158 AB065088 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RPS2 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c
    SP1:                                                        -                       -     -                                       
    SP2:                                                        -                       -                                             
    SP3:                                                        -                       -                                             
    SP4:                                                        -                                                                     
    SP5:                                                        -     -     -     -     -                                             


    ECgene alternative splicing isoforms for RPS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RPS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGCTGGTA
    RPS2 Expression
    About this image


    RPS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer
     
     Endoderm (Gastrulation Derivatives)
             Endoderm-like cells
     
     Tonsil (Hematopoietic System)
     
     Prostate (Endocrine System)
    RPS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPS2 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.356366 Hs.381079 Hs.498569 Hs.506997
        Custom PCR Arrays for RPS2
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPS2 gene from Selected species (see all 30)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rps21 , 5 ribosomal protein S21, 5 87.6(n)1
    98.63(a)1
      17 (12.51 cM)5
    168981  NM_008503.51  NP_032529.21 
     247181165 
    chicken
    (Gallus gallus)
    Aves RPS21 ribosomal protein S2 83.75(n)
    98.33(a)
      416544  NM_001277164.1  NP_001264093.1 
    lizard
    (Anolis carolinensis)
    Reptilia RPS26
    ribosomal protein S2
    94(a)
    1 ↔ 1
    GL344276.1(92072-101490)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.291552 Xenopus laevis transcribed sequence with moderate similarity more 86.94(n)    BQ897446.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb65c082 wufb65c08 81.59(n)   322564  57070873 
    fruit fly
    (Drosophila melanogaster)
    Insecta sop3
    RpS21
    protein biosynthesis structural
    constituent of more3
    Ribosomal protein S21
    83(a)3
    77.09(n)1
    83.26(a)1
      30E13
    343091  NM_001273374.11  NP_001260303.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rps-21 , 3 rps-21 78(a)3
    70.61(n)1
    77.73(a)1
      IV(7925484-7926587)3
    1775831  NM_068921.51  NP_501322.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPS2(YGL123W)4
    RPS21
    Protein component of the small (40S) subunit, essential more4
    RPS21
    60.19(n)1
    61.57(a)1
      7(277617-278381)4
    8527541, 4  NP_011392.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons XW61 XW6 66.82(n)
    76.26(a)
      842207  NM_104618.2  NP_176134.1 
    rice
    (Oryza sativa)
    Liliopsida Os.110492 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 75.16(n)    AK064984.1 


    ENSEMBL Gene Tree for RPS2 (if available)
    TreeFam Gene Tree for RPS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RPS2 gene
    4 SIMAP similar genes for RPS2 using alignment to 14 protein entries:     RS2_HUMAN (see all proteins):
    OK/KNS-cl.6    rps2    OK/KNS-cl.7    LOC392781

    RPS2 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for RPS2 (see all 65)
    PGOHUM00000238600 PGOHUM00000242315 PGOHUM00000242471 PGOHUM00000250396 PGOHUM00000242617


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RPS2 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422427CNV Duplication17116639
    dgv2547n71CNV Loss21882294
    nsv833120CNV Loss17160897
    dgv2545n71CNV Loss21882294
    dgv2549n71CNV Loss21882294
    dgv2546n71CNV Loss21882294
    nsv905048CNV Loss21882294
    dgv2551n71CNV Loss21882294
    dgv2550n71CNV Loss21882294
    dgv2540n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603624    OMIM disorders: --

    13 diseases for RPS2:    
    About MalaCards
    diamond-blackfan anemia    herpes simplex    influenza    astrocytoma
    pneumonia    adenoma    prostatitis    prostate cancer
    hiv-1    breast cancer    multiple myeloma    myeloma
    malaria

    1 disease from the University of Copenhagen DISEASES database for RPS2:
    Diamond-Blackfan anemia

    RPS2 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for RPS2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 12694581 (1)
    cancer 0 1 17184759 (1)


    Export disorders for RPS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RPS2 gene, integrated from 10 sources (see all 105):
    (articles sorted by number of sources associating them with RPS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Ribosomal protein S2 is a substrate for mammalian PRMT3 (protein arginine methyltransferase 3). (PubMed id 15473865)1, 2, 9 Swiercz R....Bedford M.T. (Biochem. J. 2005)
    2. Discovery of peptidylarginine deiminase-4 substrates by protein array: antagonistic citrullination and methylation of human ribosomal protein S2. (PubMed id 21584310)1, 2 Guo Q.... Fast W. (Mol. Biosyst. 2011)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. A map of 75 human ribosomal protein genes. (PubMed id 9582194)1, 3 Kenmochi N.... Page D.C. (Genome Res. 1998)
    5. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699)1, 2 Vladimirov S.N.... Otto A. (Eur. J. Biochem. 1996)
    6. Human cDNA sequence homologous to the mouse LLRep3 gene family. (PubMed id 2308862)1, 2 Slynn G.... Markham A.F. (Nucleic Acids Res. 1990)
    7. PRMT3 inhibits ubiquitination of ribosomal protein S2 and together forms an active enzyme complex. (PubMed id 18573314)1, 9 Choi S....Im D.S. (Biochim. Biophys. Acta 2008)
    8. Fibroblast growth factor 3, a protein with a dual subcellular fate, is interacting with human ribosomal protein S2. (PubMed id 16263090)1, 9 Antoine M....Kiefer P. (Biochem. Biophys. Res. Commun. 2005)
    9. Identification of an unconventional nuclear localization signal in human ribosomal protein S2. (PubMed id 16061210)1, 9 Antoine M....Kiefer P. (Biochem. Biophys. Res. Commun. 2005)
    10. Identification of ribosomal proteins S2 and L10a as tumor antigens recognized by HLA-A26-restricted CTL. (PubMed id 12694581)1, 9 Koga M....Itoh K. (Tissue Antigens 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6187 HGNC: 10404 AceView: RPS2 Ensembl:ENSG00000140988 euGenes: HUgn6187
    ECgene: RPS2 Kegg: 6187 H-InvDB: RPS2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RPS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RPS2 gene:
    Search GeneIP for patents involving RPS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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