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Aliases for RPS2 Gene

Aliases for RPS2 Gene

  • Ribosomal Protein S2 2 3
  • 40S Ribosomal Protein S4 3 4
  • Protein LLRep3 3 4
  • 40S Ribosomal Protein S2 3
  • OK/KNS-Cl.6 3
  • LLREP3 3
  • RPS4 4
  • S2 3

External Ids for RPS2 Gene

Previous GeneCards Identifiers for RPS2 Gene

  • GC16M002029
  • GC16M001952
  • GC16M002012

Summaries for RPS2 Gene

Entrez Gene Summary for RPS2 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S5P family of ribosomal proteins. It is located in the cytoplasm. This gene shares sequence similarity with mouse LLRep3. It is co-transcribed with the small nucleolar RNA gene U64, which is located in its third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS2 Gene

RPS2 (Ribosomal Protein S2) is a Protein Coding gene. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include RNA binding and fibroblast growth factor binding.

Gene Wiki entry for RPS2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS2 Gene

Genomics for RPS2 Gene

Regulatory Elements for RPS2 Gene

Genomic Location for RPS2 Gene

Start:
1,962,052 bp from pter
End:
1,964,860 bp from pter
Size:
2,809 bases
Orientation:
Minus strand

Genomic View for RPS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS2 Gene

Proteins for RPS2 Gene

  • Protein details for RPS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15880-RS2_HUMAN
    Recommended name:
    40S ribosomal protein S2
    Protein Accession:
    P15880
    Secondary Accessions:
    • B2R5G0
    • D3DU82
    • Q3MIB1

    Protein attributes for RPS2 Gene

    Size:
    293 amino acids
    Molecular mass:
    31324 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA35078.1; Type=Frameshift; Positions=14, 27, 40, 46, 48, 52; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPS2 Gene

neXtProt entry for RPS2 Gene

Proteomics data for RPS2 Gene at MOPED

Post-translational modifications for RPS2 Gene

  • Asymmetric arginine dimethylation by PRMT3 occurs at multiple sites in the Arg/Gly-rich region
  • Citrullinated by PADI4 in the Arg/Gly-rich region.
  • Ubiquitination at Lys58, Lys65, Lys76, Lys108, Lys114, Lys145, Lys212, Lys238, Lys246, Lys257, Lys263, and Lys275
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS2 Gene

No data available for DME Specific Peptides for RPS2 Gene

Domains for RPS2 Gene

Gene Families for RPS2 Gene

HGNC:
  • RPS :S ribosomal proteins

Graphical View of Domain Structure for InterPro Entry

P15880

UniProtKB/Swiss-Prot:

RS2_HUMAN :
  • P15880
Domain:
  • Contains 1 S5 DRBM domain.
Family:
  • Belongs to the ribosomal protein S5P family.
genes like me logo Genes that share domains with RPS2: view

Function for RPS2 Gene

Molecular function for RPS2 Gene

GENATLAS Biochemistry: 60S ribosomal protein S2

Gene Ontology (GO) - Molecular Function for RPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding --
GO:0003729 mRNA binding IDA 18464793
GO:0003735 structural constituent of ribosome IDA 15883184
GO:0005515 protein binding IPI 15473865
GO:0017134 fibroblast growth factor binding IPI 16263090
genes like me logo Genes that share ontologies with RPS2: view
genes like me logo Genes that share phenotypes with RPS2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPS2 Gene

Localization for RPS2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS2 Gene COMPARTMENTS Subcellular localization image for RPS2 gene
Compartment Confidence
cytosol 5
nucleus 5
chloroplast 2
mitochondrion 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for RPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm IDA 16061210
GO:0005730 NOT nucleolus IDA 16061210
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RPS2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS2 Gene

Pathways for RPS2 Gene

SuperPathways for RPS2 Gene

Superpath Contained pathways
1 Influenza Viral RNA Transcription and Replication
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 CFTR translational fidelity (class I mutations)
.54
4 Disease
5 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
genes like me logo Genes that share pathways with RPS2: view

Pathways by source for RPS2 Gene

1 KEGG pathway for RPS2 Gene
1 GeneGo (Thomson Reuters) pathway for RPS2 Gene

Gene Ontology (GO) - Biological Process for RPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
GO:0006415 translational termination TAS --
genes like me logo Genes that share ontologies with RPS2: view

Compounds for RPS2 Gene

(1) Novoseek inferred chemical compound relationships for RPS2 Gene

Compound -log(P) Hits PubMed IDs
arginine 34.9 1
genes like me logo Genes that share compounds with RPS2: view

Transcripts for RPS2 Gene

Unigene Clusters for RPS2 Gene

Ribosomal protein S2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPS2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c
SP1: - - -
SP2: - -
SP3: - -
SP4: -
SP5: - - - - -
SP6: - - -
SP7: - - -
SP8:
SP9: -
SP10: - - - - - -
SP11: -
SP12: -

Relevant External Links for RPS2 Gene

GeneLoc Exon Structure for
RPS2
ECgene alternative splicing isoforms for
RPS2

Expression for RPS2 Gene

mRNA expression in normal human tissues for RPS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS2 Gene

SOURCE GeneReport for Unigene cluster for RPS2 Gene Hs.356366

genes like me logo Genes that share expressions with RPS2: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS2 Gene

Orthologs for RPS2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPS2 35
  • 99.09 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia RPS2 35
  • 89.65 (n)
  • 98.98 (a)
RPS2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPS2 35
  • 88.85 (n)
  • 99.32 (a)
RPS2 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rps2 35
  • 87.6 (n)
  • 98.63 (a)
Rps2 16
Rps2-ps6 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RPS2 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPS2 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rps2 35
  • 88.17 (n)
  • 98.63 (a)
chicken
(Gallus gallus)
Aves RPS2 35
  • 83.75 (n)
  • 98.33 (a)
RPS2 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPS2 36
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.29155 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rps2 35
  • 85 (n)
  • 96.67 (a)
Str.6712 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9009 35
zebrafish
(Danio rerio)
Actinopterygii rps2 35
  • 83.48 (n)
  • 96.58 (a)
rps2 36
  • 94 (a)
OneToOne
wufb65c08 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003768 35
  • 75.6 (n)
  • 83.04 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpS2 35
  • 77.09 (n)
  • 83.26 (a)
RpS2 36
  • 81 (a)
OneToOne
sop 37
  • 83 (a)
worm
(Caenorhabditis elegans)
Secernentea rps-2 35
  • 70.61 (n)
  • 77.73 (a)
rps-2 36
  • 71 (a)
OneToOne
rps-2 37
  • 78 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR177W 35
  • 64.44 (n)
  • 60 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS2 35
  • 60.19 (n)
  • 61.57 (a)
RPS2 36
  • 58 (a)
OneToOne
RPS2 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F09812g 35
  • 62.19 (n)
  • 62.04 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7153 35
thale cress
(Arabidopsis thaliana)
eudicotyledons XW6 35
  • 66.82 (n)
  • 76.26 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.4103 35
corn
(Zea mays)
Liliopsida Zm.7140 35
rice
(Oryza sativa)
Liliopsida Os.11049 35
Os03g0807800 35
  • 72.4 (n)
  • 71.49 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.28855 35
bread mold
(Neurospora crassa)
Ascomycetes NCU06047 35
  • 70.32 (n)
  • 69.86 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps2 35
  • 65.33 (n)
  • 67.56 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4371 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10600 36
  • 81 (a)
OneToOne
Species with no ortholog for RPS2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPS2 Gene

ENSEMBL:
Gene Tree for RPS2 (if available)
TreeFam:
Gene Tree for RPS2 (if available)

Paralogs for RPS2 Gene

genes like me logo Genes that share paralogs with RPS2: view

No data available for Paralogs for RPS2 Gene

Variants for RPS2 Gene

Structural Variations from Database of Genomic Variants (DGV) for RPS2 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
dgv2540n71 CNV Loss 21882294
dgv2544n71 CNV Loss 21882294
dgv2545n71 CNV Loss 21882294
nsv833120 CNV Loss 17160897
nsv905048 CNV Loss 21882294
dgv2546n71 CNV Loss 21882294
dgv2547n71 CNV Loss 21882294
dgv2548n71 CNV Gain 21882294
dgv2549n71 CNV Loss 21882294
dgv2550n71 CNV Loss 21882294
nsv905061 CNV Loss 21882294
dgv2551n71 CNV Loss 21882294
nsv471070 CNV Gain 18288195
nsv905070 CNV Gain+Loss 21882294
dgv2552n71 CNV Gain+Loss 21882294

Relevant External Links for RPS2 Gene

HapMap Linkage Disequilibrium report
RPS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for RPS2 Gene

Disorders for RPS2 Gene

(1) University of Copenhagen DISEASES for RPS2 Gene

(2) Novoseek inferred disease relationships for RPS2 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 1
cancer 0 1
genes like me logo Genes that share disorders with RPS2: view

No data available for UniProtKB/Swiss-Prot for RPS2 Gene

Publications for RPS2 Gene

  1. Ribosomal protein S2 is a substrate for mammalian PRMT3 (protein arginine methyltransferase 3). (PMID: 15473865) Swiercz R. … Bedford M.T. (Biochem. J. 2005) 3 4 23
  2. Identification of an unconventional nuclear localization signal in human ribosomal protein S2. (PMID: 16061210) Antoine M. … Kiefer P. (Biochem. Biophys. Res. Commun. 2005) 3 23
  3. Identification of ribosomal proteins S2 and L10a as tumor antigens recognized by HLA-A26-restricted CTL. (PMID: 12694581) Koga M. … Itoh K. (Tissue Antigens 2003) 3 23
  4. PRMT3 inhibits ubiquitination of ribosomal protein S2 and together forms an active enzyme complex. (PMID: 18573314) Choi S. … Im D.S. (Biochim. Biophys. Acta 2008) 3 23
  5. Human cDNA sequence homologous to the mouse LLRep3 gene family. (PMID: 2308862) Slynn G. … Markham A.F. (Nucleic Acids Res. 1990) 3 4

Products for RPS2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate RPS2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for RPS2
    • Block miRNA regulation of RPS2 using miScript Target Protectors

    Sources for RPS2 Gene

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