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Set Analyses:

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RPS2 Gene

protein-coding GIFtS: 64
GCID: GC16M002012

Ribosomal Protein S2

Microbiology & Infectious Diseases Congress

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at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Ribosomal Protein S2¹ ²		LLREP3²
Protein LLRep3² ³		OK/KNS-cl.6²
40S Ribosomal Protein S4² ³		S2²
40S Ribosomal Protein S2²		RPS4³

External Ids:	HGNC: 10404¹	Entrez Gene: 6187²	Ensembl: ENSG00000140988⁷	OMIM: 603624⁵	UniProtKB: P15880³

Export aliases for RPS2 gene to outside databases

Previous GC identifers: GC16M002029 GC16M001952

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RPS2 Gene:

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.

Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This

gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S5P family of

ribosomal proteins. It is located in the cytoplasm. This gene shares sequence similarity with mouse LLRep3. It is

co-transcribed with the small nucleolar RNA gene U64, which is located in its third intron. As is typical for

genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the

genome. (provided by RefSeq, Jul 2008)

GeneCards Summary for RPS2 Gene:

RPS2 (ribosomal protein S2) is a protein-coding gene. Diseases associated with RPS2 include diamond-blackfan anemia, and herpes simplex. GO annotations related to this gene include fibroblast growth factor binding and RNA binding.

Gene Wiki entry for RPS2 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000016.10 NC_018927.2 NT_010393.17

Regulatory elements:

Regulatory transcription factor binding sites in the RPS2 gene promoter:
SRF NF-1 NF-1/L AML1a MAZR Pax-5 SRF (504 AA) AP-4 YY1 STAT3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RPS2 promoter sequence

Search Chromatin IP Primers for RPS2

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPS2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3

RPS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS2 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M002012: view genomic region (about GC identifiers)

Start:	2,012,053 bp from pter	End:	2,014,861 bp from pter
Size:	2,809 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RS2_HUMAN, P15880 (See protein sequence)

Recommended Name: 40S ribosomal protein S2

Size: 293 amino acids; 31324 Da

Sequence caution: Sequence=CAA35078.1; Type=Frameshift; Positions=14, 27, 40, 46, 48, 52;

1 PDB 3D structure from and Proteopedia for RPS2:

3J3A (3D)

Secondary accessions: B2R5G0 D3DU82 Q3MIB1

Explore the universe of human proteins at neXtProt for RPS2: NX_P15880

Explore proteomics data for RPS2 at MOPED

Post-translational modifications:

Citrullinated by PADI4 in the Arg/Gly-rich region¹

Asymmetric arginine dimethylation by PRMT3 occurs at multiple sites in the Arg/Gly-rich region¹

Ubiquitination² at Lys58, Lys65, Lys76, Lys108, Lys114, Lys145, Lys212, Lys238, Lys246, Lys257,
Lys263, Lys275

Modification sites at PhosphoSitePlus

See RPS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_002943.2

ENSEMBL proteins:

ENSP00000341885 ENSP00000436865 ENSP00000460860 ENSP00000436227 ENSP00000434846

ENSP00000436356 ENSP00000433170 ENSP00000433034 ENSP00000454837

Reactome Protein details: P15880

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

RPS: S ribosomal proteins

Selected InterPro protein domains (see all 8):

IPR005711 Ribosomal_S5_euk/arc

IPR013810 Ribosomal_S5_N

IPR014720 dsRNA-bd_dom

IPR005324 Ribosomal_S5_C

IPR020568 Ribosomal_S5_D2-typ_fold

Graphical View of Domain Structure for InterPro Entry P15880

ProtoNet protein and cluster: P15880

2 Blocks protein domains:

IPB000851 Ribosomal protein S5

IPB011070 Globular protein

UniProtKB/Swiss-Prot: RS2_HUMAN, P15880

Similarity: Belongs to the ribosomal protein S5P family

Similarity: Contains 1 S5 DRBM domain

RPS2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

Genatlas biochemistry entry for RPS2:

60S ribosomal protein S2

Gene Ontology (GO): Selected molecular function terms (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003723	RNA binding	--	--
GO:0003729	mRNA binding	IDA	18464793
GO:0003735	structural constituent of ribosome	IDA	15883184
GO:0005515	protein binding	IPI	15473865
GO:0017134	fibroblast growth factor binding	IPI	16263090

RPS2 for ontologies About GeneDecksing

Phenotypes:
6 GenomeRNAi human phenotypes for RPS2:

Cytoplasmic 40S maturation def	Decreased G3BP1 protein expres	Decreased Hepatitis C virus re	Increased cell death HMECs cel
Increased cell number in S	Increased gamma-H2AX phosphory

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RPS2

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miRNA Products:		miRTarBase miRNAs that target RPS2: hsa-mir-1250-5p (MIRT035864), hsa-mir-196a-5p (MIRT048173), hsa-mir-361-5p (MIRT044087), hsa-mir-186-5p (MIRT045205), hsa-mir-361-3p (MIRT038274), hsa-mir-423-5p (MIRT038055), hsa-mir-222-3p (MIRT046672), hsa-mir-34a-5p (MIRT047364), hsa-mir-324-5p (MIRT043030), hsa-mir-760 (MIRT036761), hsa-mir-1301-3p (MIRT036012), hsa-mir-25-5p (MIRT038957), hsa-mir-455-3p (MIRT037900), hsa-mir-18a-3p (MIRT040839), hsa-mir-615-3p (MIRT040163), hsa-mir-16-5p (MIRT031671), hsa-mir-125a-5p (MIRT045736), hsa-mir-940 (MIRT036604), hsa-mir-330-3p (MIRT043827), hsa-mir-3943 (MIRT052895), hsa-mir-99b-5p (MIRT044194), hsa-mir-423-3p (MIRT042586), hsa-mir-328-3p (MIRT043802), hsa-mir-22-3p (MIRT050452), hsa-mir-331-3p (MIRT043266)

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS2

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytosol	5
nucleus	5
chloroplast	2
mitochondrion	2
peroxisome	1

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Gene Ontology (GO): Selected cellular component terms (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005654	nucleoplasm	IDA	16061210
GO:0005730	NOT nucleolus	IDA	16061210
GO:0005829	cytosol	TAS	--
GO:0005840	ribosome	--	--
GO:0015935	small ribosomal subunit	--	--

RPS2 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for RPS2 About (see all 6)

See pathways by source

SuperPath

Selected contained pathways About (see all per SuperPath)

CFTR translational fidelity class I mutations

	CFTR translational fidelity class I mutations	0.60			Ribosome	0.54
	Cytoplasmic Ribosomal Proteins	0.60

Influenza Viral RNA Transcription and Replication

Viral mRNA Translation	0.94	Eukaryotic Translation Initiation	0.89
Peptide chain elongation	0.94	Cap-dependent Translation Initiation	0.89
Nonsense Mediated Decay Independent of the Exon Junction Complex	0.94	Nonsense Mediated Decay Enhanced by the Exon Junction Complex	0.89
Formation of a pool of free 40S subunits	0.94	Nonsense-Mediated Decay	0.89

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

	Translation initiation complex formation	0.91			Ribosomal scanning and start codon recognition	0.91
	Formation of the ternary complex, and subsequently, the 43S complex	0.91			Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	0.90

Gene Expression

Gene Expression

0.40

Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein

Metabolism of proteins

0.30

Pathways by source See SuperPaths
Show all pathways

1 GeneGo (Thomson Reuters) Pathway for RPS2

CFTR translational fidelity (class I mutations)

1 BioSystems Pathway for RPS2

Cytoplasmic Ribosomal Proteins

Selected Reactome Pathways for RPS2 (see all 12)

	Peptide chain elongation
	Formation of the ternary complex, and subsequently, the 43S complex
	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
	Viral mRNA Translation
	GTP hydrolysis and joining of the 60S ribosomal subunit

1 Kegg Pathway (Kegg details for RPS2):

Ribosome

RPS2 for pathways About GeneDecksing

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for RPS2
Interactions:

GeneGlobe Interaction Network for RPS2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for RPS2 (P15880^{2, 3} ENSP00000341885⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 493)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RPS15A	P62244²^,³, ENSP00000318646⁴	MINT-6542674 MINT-6489539 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=4 STRING: ENSP00000318646
RPL11	P62913²^,³, ENSP00000363676⁴	MINT-6542674 MINT-6489539 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=3 STRING: ENSP00000363676
RPS3	P23396²^,³, ENSP00000278572⁴	MINT-6542674 MINT-6489539 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=3 STRING: ENSP00000278572
RPL26	P61254²^,³	MINT-6542674 MINT-6489539 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=2
RPL27A	P46776²^,³, ENSP00000346015⁴	MINT-6489539 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=2 STRING: ENSP00000346015

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Gene Ontology (GO): Selected biological process terms (see all 14): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS	--
GO:0006412	translation	TAS	--
GO:0006413	translational initiation	TAS	--
GO:0006414	translational elongation	TAS	--
GO:0006415	translational termination	TAS	--

RPS2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for RPS2 (RS2)

1 Novoseek inferred chemical compound relationship for RPS2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
arginine	34.9	1	15473865 (1)

RPS2 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for RPS2 gene:

NM_002952.3

Unigene Clusters for RPS2:

Ribosomal protein S2

Hs.356366 [show with all ESTs], Hs.381079 [show with all ESTs], Hs.498569 [show with all ESTs], Hs.506997 [show with all ESTs]

Unigene Representative Sequences: BG165653, BM467031, BF972117, BM423570

17 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000343262(uc002cno.2) ENST00000526522 ENST00000526586 ENST00000533186

ENST00000532746 ENST00000533872 ENST00000527109(uc002cnm.2) ENST00000527871

ENST00000530225 ENST00000531065 ENST00000533161(uc002cnn.2) ENST00000529806

ENST00000534461 ENST00000527302 ENST00000526908 ENST00000527826 ENST00000563194

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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		Predesigned siRNA for gene silencing in human, mouse, rat RPS2

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Additional mRNA sequence:

AB082925.1 AL832857.1 BC001795.1 BC006559.2 BC008329.2 BC008862.2 BC010165.2 BC012354.1

BC013833.1 BC016178.1 BC016951.2 BC018993.2 BC019021.2 BC021545.1 BC023541.1 BC025677.1

BC029979.1 BC032129.2 BC035427.1 BC066321.1 BC068051.1 BC071673.1 BC071922.1 BC071923.1

BC071924.1 BC073966.1 BC075830.1 BC105985.1 BC106060.1

Selected DOTS entries (see all 346):

DT.95277449 DT.100640089 DT.100763615 DT.95277540 DT.100737773 DT.92411543 DT.100737906 DT.100737854

DT.100737763 DT.91940355 DT.97849492 DT.99926730 DT.100846786 DT.75177498 DT.92473920 DT.87010305

DT.97869804 DT.92473980 DT.99926712 DT.100737891 DT.92474003 DT.120702433 DT.97869788 DT.100737858

Selected AceView cDNA sequences (see all 260):

CR620130 CR605226 CR606602 CR624847 CR612811 BG876857 CR596231 CR607612

CR607006 CR622407 AI971893 CR609604 AB065089 CR608202 BC004520 BC063011

CR617837 CN484452 CR601170 CR613584 CR593005 CR607747 Y11158 AB065088

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for RPS2 (see all 12) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	·	1g	^	2	^	3a	·	3b	·	3c	·	3d	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	^	7a	·	7b	·	7c
SP1:																			-								-		-
SP2:																			-								-
SP3:																			-								-
SP4:																			-
SP5:																			-		-		-		-		-

ECgene alternative splicing isoforms for RPS2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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RPS2 expression in normal human tissues (normalized intensities) RPS2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ATGGCTGGTA

About this image

RPS2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 5) fully expand


Epithelial Cells
Presumptive Podocytes Podocyte Layer

Kidney (Urinary System)
Presumptive Podocytes Podocyte Layer

Endoderm (Gastrulation Derivatives)
Endoderm-like cells

Tonsil (Hematopoietic System)

Prostate (Endocrine System)

RPS2 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

RPS2 Protein Expression

SOURCE GeneReport for Unigene clusters: Hs.356366 Hs.381079 Hs.498569 Hs.506997

Custom PCR Arrays for RPS2

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS2 gene from Selected species (see all 30) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rps2^{1 , 5}	ribosomal protein S2^{1, 5}	87.6(n)¹ 98.63(a)¹		17 (12.51 cM)⁵ 16898¹ NM_008503.5¹ NP_032529.2¹ 24718116⁵
chicken (Gallus gallus)	Aves	RPS2¹	ribosomal protein S2	83.75(n) 98.33(a)		416544 NM_001277164.1 NP_001264093.1
lizard (Anolis carolinensis)	Reptilia	RPS2⁶	ribosomal protein S2	94(a)	1 ↔ 1	GL344276.1(92072-101490)
African clawed frog (Xenopus laevis)	Amphibia	Xl.29155²	Xenopus laevis transcribed sequence with moderate similarity more	86.94(n)		BQ897446.1
zebrafish (Danio rerio)	Actinopterygii	wufb65c08²	wufb65c08	81.59(n)		322564 57070873
fruit fly (Drosophila melanogaster)	Insecta	sop³ RpS2¹	protein biosynthesis structural constituent of more³ Ribosomal protein S2¹	83(a)³ 77.09(n)¹ 83.26(a)¹		30E1³ 34309¹ NM_001273374.1¹ NP_001260303.1¹
worm (Caenorhabditis elegans)	Secernentea	rps-2^{1 , 3}	rps-2¹	78(a)³ 70.61(n)¹ 77.73(a)¹		IV(7925484-7926587)³ 177583¹ NM_068921.5¹ NP_501322.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	RPS2(YGL123W)⁴ RPS2¹	Protein component of the small (40S) subunit, essential more⁴ RPS2¹	60.19(n)¹ 61.57(a)¹		7(277617-278381)⁴ 852754^{1, 4} NP_011392.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	XW6¹	XW6	66.82(n) 76.26(a)		842207 NM_104618.2 NP_176134.1
rice (Oryza sativa)	Liliopsida	Os.11049²	Oryza sativa (japonica cultivar-group) cDNA cloneJ more	75.16(n)		AK064984.1

ENSEMBL Gene Tree for RPS2 (if available)
TreeFam Gene Tree for RPS2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for RPS2 gene

4 SIMAP similar genes for RPS2 using alignment to 14 protein entries: RS2_HUMAN (see all proteins):

OK/KNS-cl.6 rps2 OK/KNS-cl.7 LOC392781

RPS2 for paralogs About GeneDecksing

Selected Pseudogenes.org Pseudogenes for RPS2 (see all 65)
PGOHUM00000238600 PGOHUM00000242315 PGOHUM00000242471 PGOHUM00000250396 PGOHUM00000242617

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Structural Variations
Database of Genomic Variants (DGV) Selected variations for RPS2 (see all 16): About this table

Variant ID	Type	Subtype	PubMed ID
esv2422427	CNV	Duplication	17116639
dgv2547n71	CNV	Loss	21882294
nsv833120	CNV	Loss	17160897
dgv2545n71	CNV	Loss	21882294
dgv2549n71	CNV	Loss	21882294
dgv2546n71	CNV	Loss	21882294
nsv905048	CNV	Loss	21882294
dgv2551n71	CNV	Loss	21882294
dgv2550n71	CNV	Loss	21882294
dgv2540n71	CNV	Loss	21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 603624 OMIM disorders: --

13 diseases for RPS2: About MalaCards

diamond-blackfan anemia herpes simplex influenza astrocytoma

pneumonia adenoma prostatitis prostate cancer

hiv-1 breast cancer multiple myeloma myeloma

malaria

1 disease from the University of Copenhagen DISEASES database for RPS2:

Diamond-Blackfan anemia

RPS2 for disorders About GeneDecksing

2 Novoseek inferred disease relationships for RPS2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	1	12694581 (1)
cancer	0	1	17184759 (1)

Export disorders for RPS2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RPS2 gene, integrated from 10 sources (see all 105):
(articles sorted by number of sources associating them with RPS2)

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Ribosomal protein S2 is a substrate for mammalian PRMT3 (protein arginine methyltransferase 3). (PubMed id 15473865)^{1, 2, 9} Swiercz R....Bedford M.T. (Biochem. J. 2005)
Discovery of peptidylarginine deiminase-4 substrates by protein array: antagonistic citrullination and methylation of human ribosomal protein S2. (PubMed id 21584310)^{1, 2} Guo Q.... Fast W. (Mol. Biosyst. 2011)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
A map of 75 human ribosomal protein genes. (PubMed id 9582194)^{1, 3} Kenmochi N.... Page D.C. (Genome Res. 1998)
Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699)^{1, 2} Vladimirov S.N.... Otto A. (Eur. J. Biochem. 1996)
Human cDNA sequence homologous to the mouse LLRep3 gene family. (PubMed id 2308862)^{1, 2} Slynn G.... Markham A.F. (Nucleic Acids Res. 1990)
PRMT3 inhibits ubiquitination of ribosomal protein S2 and together forms an active enzyme complex. (PubMed id 18573314)^{1, 9} Choi S....Im D.S. (Biochim. Biophys. Acta 2008)
Fibroblast growth factor 3, a protein with a dual subcellular fate, is interacting with human ribosomal protein S2. (PubMed id 16263090)^{1, 9} Antoine M....Kiefer P. (Biochem. Biophys. Res. Commun. 2005)
Identification of an unconventional nuclear localization signal in human ribosomal protein S2. (PubMed id 16061210)^{1, 9} Antoine M....Kiefer P. (Biochem. Biophys. Res. Commun. 2005)
Identification of ribosomal proteins S2 and L10a as tumor antigens recognized by HLA-A26-restricted CTL. (PubMed id 12694581)^{1, 9} Koga M....Itoh K. (Tissue Antigens 2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6187	HGNC: 10404	AceView: RPS2	Ensembl:ENSG00000140988	euGenes: HUgn6187
ECgene: RPS2	Kegg: 6187	H-InvDB: RPS2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RPS2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RPS2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for RPS2 gene:
Search GeneIP for patents involving RPS2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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