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RPS2 Gene(Protein Coding)

Ribosomal Protein S2

GCID:
GC16M002045
GIFtS:
60
Genes Participants
UDN Logo

Aliases for RPS2 Gene

Aliases for RPS2 Gene

  • Ribosomal Protein S2 2 3 5
  • 40S Ribosomal Protein S4 3 4
  • Protein LLRep3 3 4
  • 40S Ribosomal Protein S2 3
  • OK/KNS-Cl.6 3
  • LLREP3 3
  • RPS4 4
  • S2 3

External Ids for RPS2 Gene

Previous GeneCards Identifiers for RPS2 Gene

  • GC16M002029
  • GC16M001952
  • GC16M002012
  • GC16M001967
  • GC16M001975
  • GC16M001983
  • GC16M002007

Summaries for RPS2 Gene

Entrez Gene Summary for RPS2 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S5P family of ribosomal proteins. It is located in the cytoplasm. This gene shares sequence similarity with mouse LLRep3. It is co-transcribed with the small nucleolar RNA gene U64, which is located in its third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS2 Gene

RPS2 (Ribosomal Protein S2) is a Protein Coding gene. Diseases associated with RPS2 include Diamond-Blackfan Anemia. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Metabolism. GO annotations related to this gene include poly(A) RNA binding and enzyme binding.

Gene Wiki entry for RPS2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS2 Gene

Genomics for RPS2 Gene

Products:

  1. Regulatory Element

Regulatory Elements for RPS2 Gene

Enhancers for RPS2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F001962 1.2 ENCODE 6.7 +0.6 639 4.1 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 FOS ENSG00000255513 SNHG9 RPL3L ENSG00000261505 LOC105371055 TRAF7 ENSG00000226890 ENSG00000200059 ENSG00000261240 PRSS29P
GH16F001078 1.3 Ensembl ENCODE 5.1 +886.2 886207 1.2 PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF48 BRCA1 SLC30A9 FOS IFT140 ENSG00000269482 LOC105371038 HN1L NME3 CCDC154 ENSG00000262528 ENSG00000268836 EME2 SSTR5-AS1
GH16F002919 0.9 ENCODE 5.2 -954.8 -954752 0.2 ATF1 ARID4B SIN3A RAD21 ZNF121 ZNF335 ZNF143 ZNF362 ZNF654 SMAD5 KREMEN2 PAQR4 PKMYT1 PRSS22 PRSS27 RPS2 GC16M002924 FLYWCH1
GH16F002920 0.9 ENCODE 5.2 -955.0 -954975 0.2 ARID4B KLF17 SIN3A RAD21 ZNF121 ZNF335 ZNF143 ZNF362 ZNF654 REST KREMEN2 PAQR4 PKMYT1 PRSS22 SNORD60 PRSS27 SNHG19 PRSS30P RPS2 SRRM2
GH16F002427 1.4 FANTOM5 ENCODE 2.5 -464.4 -464389 2.8 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF766 CBX5 TIGD7 MEFV IFT140 MTCO1P28 CCNF LOC652276 KCTD5 DNASE1L2 ELOB MLST8
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPS2 on UCSC Golden Path with GeneCards custom track

Promoters for RPS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000502379 360 2601 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 FOS

Transcription factor binding sites by QIAGEN in the RPS2 gene promoter:

Genomic Location for RPS2 Gene

Chromosome:
16
Start:
1,962,052 bp from pter
End:
1,964,860 bp from pter
Size:
2,809 bases
Orientation:
Minus strand

Genomic View for RPS2 Gene

Genes around RPS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for RPS2 Gene

Proteins for RPS2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for RPS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15880-RS2_HUMAN
    Recommended name:
    40S ribosomal protein S2
    Protein Accession:
    P15880
    Secondary Accessions:
    • B2R5G0
    • D3DU82
    • Q3MIB1

    Protein attributes for RPS2 Gene

    Size:
    293 amino acids
    Molecular mass:
    31324 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA35078.1; Type=Frameshift; Positions=14, 27, 40, 46, 48, 52; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPS2 Gene

neXtProt entry for RPS2 Gene

Protein Expression for RPS2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for RPS2 Gene

  • Asymmetric arginine dimethylation by PRMT3 occurs at multiple sites in the Arg/Gly-rich region.
  • Citrullinated by PADI4 in the Arg/Gly-rich region.
  • Ubiquitination at Lys 58, Lys 65, Lys 114, Lys 145, Lys 212, Lys 238, Lys 246, Lys 257, Lys 263, and Lys 275
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPS2 Gene

Domains & Families for RPS2 Gene

Gene Families for RPS2 Gene

HGNC:

Protein Domains for RPS2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RPS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P15880

UniProtKB/Swiss-Prot:

RS2_HUMAN :
  • Contains 1 S5 DRBM domain.
  • Belongs to the ribosomal protein S5P family.
Domain:
  • Contains 1 S5 DRBM domain.
Family:
  • Belongs to the ribosomal protein S5P family.
genes like me logo Genes that share domains with RPS2: view

Function for RPS2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for RPS2 Gene

GENATLAS Biochemistry:
60S ribosomal protein S2

Gene Ontology (GO) - Molecular Function for RPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0003729 mRNA binding IDA 18464793
GO:0003735 structural constituent of ribosome IEA,IDA 15883184
GO:0005515 protein binding IPI 15473865
GO:0017134 fibroblast growth factor binding IPI 16263090
genes like me logo Genes that share ontologies with RPS2: view
genes like me logo Genes that share phenotypes with RPS2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS2 Gene

Localization for RPS2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS2 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
mitochondrion 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for RPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm IDA,TAS --
GO:0005730 NOT nucleolus IDA 16061210
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RPS2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS2 Gene

Pathways & Interactions for RPS2 Gene

SuperPathways for RPS2 Gene

PathCards logo More details on SuperPathways for RPS2
SuperPathway Contained pathways
1 Viral mRNA Translation
Eukaryotic Translation Elongation
.95
Peptide chain elongation
.95
Cap-dependent Translation Initiation
.94
Eukaryotic Translation Initiation
.94
GTP hydrolysis and joining of the 60S ribosomal subunit
.94
L13a-mediated translational silencing of Ceruloplasmin expression
.94
Selenocysteine synthesis
.93
Viral mRNA Translation
.93
Eukaryotic Translation Termination
.92
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
.91
Formation of a pool of free 40S subunits
.90
Cytoplasmic Ribosomal Proteins
.84
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
.83
Nonsense-Mediated Decay (NMD)
.83
Selenoamino acid metabolism
.78
CFTR translational fidelity (class I mutations)
.78
SRP-dependent cotranslational protein targeting to membrane
.77
Translation
.77
Ribosome
.55
Metabolism of amino acids and derivatives
.34
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
.94
Ribosomal scanning and start codon recognition
.94
Formation of the ternary complex, and subsequently, the 43S complex
.87
Translation initiation complex formation
.86
3 rRNA processing in the nucleus and cytosol
Major pathway of rRNA processing in the nucleolus and cytosol
.94
rRNA processing in the nucleus and cytosol
.94
rRNA processing
.89
rRNA modification in the nucleus and cytosol
.33
4 Influenza Viral RNA Transcription and Replication
Influenza Life Cycle
.94
Influenza Viral RNA Transcription and Replication
.94
Influenza Infection
.93
5 Chromatin organization
Chromatin modifying enzymes
.51
Chromatin organization
.51
genes like me logo Genes that share pathways with RPS2: view

Pathways by source for RPS2 Gene

1 BioSystems pathway for RPS2 Gene
1 KEGG pathway for RPS2 Gene
1 GeneGo (Thomson Reuters) pathway for RPS2 Gene

Gene Ontology (GO) - Biological Process for RPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,IC 8706699
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPS2: view

No data available for SIGNOR curated interactions for RPS2 Gene

Drugs & Compounds for RPS2 Gene

Products:

  1. Drug

(1) Drugs for RPS2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with RPS2: view

Transcripts for RPS2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for RPS2 Gene

(1) REFSEQ mRNAs :
(40) Additional mRNA sequences :
(260) Selected AceView cDNA sequences:
(17) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RPS2 Gene

Ribosomal protein S2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c
SP1: - - -
SP2: - -
SP3: - -
SP4: -
SP5: - - - - -
SP6: - - -
SP7: - - -
SP8:
SP9: -
SP10: - - - - - -
SP11: -
SP12: -

Relevant External Links for RPS2 Gene

GeneLoc Exon Structure for
RPS2
ECgene alternative splicing isoforms for
RPS2

Expression for RPS2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPS2 Gene

mRNA expression in normal human tissues for RPS2 Gene
mRNA expression by BioGPS for RPS2 GenemRNA expression by GTEx for RPS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPS2 Gene

This gene is overexpressed in Nasal epithelium (6.9) and Tlymphocyte (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPS2 Gene



Protein tissue co-expression partners for RPS2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS2 Gene:

RPS2

SOURCE GeneReport for Unigene cluster for RPS2 Gene:

Hs.356366
genes like me logo Genes that share expression patterns with RPS2: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS2 Gene

Orthologs for RPS2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia RPS2 34
  • 99.09 (n)
mouse
(Mus musculus)
 Mammalia Rps2-ps6 35
  • 99 (a)
 OneToOne
Rps2 34 16
  • 87.6 (n)
cow
(Bos Taurus)
 Mammalia RPS2 34 35
  • 89.65 (n)
dog
(Canis familiaris)
 Mammalia RPS2 34 35
  • 88.85 (n)
rat
(Rattus norvegicus)
 Mammalia Rps2 34
  • 88.17 (n)
oppossum
(Monodelphis domestica)
 Mammalia RPS2 35
  • 86 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia RPS2 35
  • 81 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves RPS2 34 35
  • 83.75 (n)
lizard
(Anolis carolinensis)
 Reptilia RPS2 35
  • 94 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia rps2 34
  • 85 (n)
Str.6712 34
African clawed frog
(Xenopus laevis)
 Amphibia Xl.29155 34
zebrafish
(Danio rerio)
 Actinopterygii rps2 34 35
  • 83.48 (n)
wufb65c08 34
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.9009 34
fruit fly
(Drosophila melanogaster)
 Insecta sop 36
  • 83 (a)
RpS2 34 35
  • 77.09 (n)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP003768 34
  • 75.6 (n)
worm
(Caenorhabditis elegans)
 Secernentea rps-2 36 34 35
  • 70.61 (n)
A. gosspyii yeast
(Ashbya gossypii)
 Saccharomycetes AGOS_AAR177W 34
  • 64.44 (n)
K. lactis yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0F09812g 34
  • 62.19 (n)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes RPS2 34 35 37
  • 60.19 (n)
thale cress
(Arabidopsis thaliana)
 eudicotyledons XW6 34
  • 66.82 (n)
Alicante grape
(Vitis vinifera)
 eudicotyledons Vvi.7153 34
rice
(Oryza sativa)
 Liliopsida Os03g0807800 34
  • 72.4 (n)
Os.11049 34
barley
(Hordeum vulgare)
 Liliopsida Hv.4103 34
wheat
(Triticum aestivum)
 Liliopsida Ta.28855 34
corn
(Zea mays)
 Liliopsida Zm.7140 34
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.10600 35
  • 81 (a)
 OneToOne
bread mold
(Neurospora crassa)
 Ascomycetes NCU06047 34
  • 70.32 (n)
fission yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes rps2 34
  • 65.33 (n)
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.4371 34
Species where no ortholog for RPS2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPS2 Gene

ENSEMBL:
Gene Tree for RPS2 (if available)
TreeFam:
Gene Tree for RPS2 (if available)

Paralogs for RPS2 Gene

(4) SIMAP similar genes for RPS2 Gene using alignment to 14 proteins:

Pseudogenes.org Pseudogenes for RPS2 Gene

genes like me logo Genes that share paralogs with RPS2: view

No data available for Paralogs for RPS2 Gene

Variants for RPS2 Gene

Sequence variations from dbSNP and Humsavar for RPS2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1054002 -- 1,965,431(+) TGACA(C/T)CGACG nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB
rs1054003 -- 1,965,476(+) TCCCA(C/T)GTCTT nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB
rs111356132 -- 1,963,486(+) TGGAG(C/T)GCGCC intron-variant, upstream-variant-2KB
rs111458254 -- 1,965,172(+) TGGTC(C/T)TCGAG intron-variant, upstream-variant-2KB
rs111548082 -- 1,964,109(+) ATCCA(A/C)CCTCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPS2 Gene

Variant ID Type Subtype PubMed ID
nsv984249 CNV duplication 23825009
nsv952901 CNV deletion 24416366
nsv833120 CNV loss 17160897
nsv571179 CNV loss 21841781
nsv471070 CNV gain 18288195
nsv1160329 CNV deletion 26073780
esv2422427 CNV duplication 17116639
dgv4858n54 CNV loss 21841781

Variation tolerance for RPS2 Gene

Residual Variation Intolerance Score: 35.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 8.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS2 Gene

Disorders for RPS2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPS2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
diamond-blackfan anemia
  • blackfan - diamond syndrome
- elite association - COSMIC cancer census association via MalaCards
Search RPS2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RPS2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPS2
genes like me logo Genes that share disorders with RPS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS2 Gene

Publications for RPS2 Gene

  1. Ribosomal protein S2 is a substrate for mammalian PRMT3 (protein arginine methyltransferase 3). (PMID: 15473865) Swiercz R. … Bedford M.T. (Biochem. J. 2005) 3 4 22 64
  2. Discovery of peptidylarginine deiminase-4 substrates by protein array: antagonistic citrullination and methylation of human ribosomal protein S2. (PMID: 21584310) Guo Q. … Fast W. (Mol. Biosyst. 2011) 3 4 64
  3. PRMT3 inhibits ubiquitination of ribosomal protein S2 and together forms an active enzyme complex. (PMID: 18573314) Choi S. … Im D.S. (Biochim. Biophys. Acta 2008) 3 22 64
  4. Identification of an unconventional nuclear localization signal in human ribosomal protein S2. (PMID: 16061210) Antoine M. … Kiefer P. (Biochem. Biophys. Res. Commun. 2005) 3 22 64
  5. Fibroblast growth factor 3, a protein with a dual subcellular fate, is interacting with human ribosomal protein S2. (PMID: 16263090) Antoine M. … Kiefer P. (Biochem. Biophys. Res. Commun. 2005) 3 22 64

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