Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPS2 Gene

protein-coding   GIFtS: 63
GCID: GC16M002012

Ribosomal Protein S2
Microbiology & Infectious Diseases Congress
  See related diseases
at
MalaCards
 

Aliases
for RPS2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Ribosomal Protein S21 2     LLREP32
Protein LLRep32 3     OK/KNS-cl.62
40S Ribosomal Protein S42 3     S22
40S Ribosomal Protein S22     RPS43

External Ids:    HGNC: 104041   Entrez Gene: 61872   Ensembl: ENSG000001409887   OMIM: 6036245   UniProtKB: P158803   

Export aliases for RPS2 gene to outside databases

Previous GC identifers: GC16M002029 GC16M001952


Summaries
for RPS2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RPS2 Gene:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This
gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S5P family of
ribosomal proteins. It is located in the cytoplasm. This gene shares sequence similarity with mouse LLRep3. It is
co-transcribed with the small nucleolar RNA gene U64, which is located in its third intron. As is typical for
genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the
genome. (provided by RefSeq, Jul 2008)

GeneCards Summary for RPS2 Gene: 
RPS2 (ribosomal protein S2) is a protein-coding gene. Diseases associated with RPS2 include diamond-blackfan anemia, and herpes simplex, and among its related super-pathways are Eukaryotic Translation Initiation and Formation of the ternary complex, and subsequently, the 43S complex. GO annotations related to this gene include fibroblast growth factor binding and RNA binding.

Gene Wiki entry for RPS2 Gene


Genomic Views
for RPS2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPS2 gene promoter:
         SRF   NF-1   NF-1/L   AML1a   MAZR   Pax-5   SRF (504 AA)   AP-4   YY1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RPS2 promoter sequence
   Search SABiosciences Chromatin IP Primers for RPS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

RPS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M002012:  view genomic region     (about GC identifiers)

Start:
 2,012,053 bp from pter      End:
 2,014,861 bp from pter
Size:
 2,809 bases      Orientation:
 minus strand

Proteins
for RPS2 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: RS2_HUMAN, P15880 (See protein sequence)
Recommended Name: 40S ribosomal protein S2  
Size: 293 amino acids; 31324 Da
Sequence caution: Sequence=CAA35078.1; Type=Frameshift; Positions=14, 27, 40, 46, 48, 52;
1 PDB 3D structure from and Proteopedia for RPS2:
3J3A (3D)    
Secondary accessions: B2R5G0 D3DU82 Q3MIB1

Explore the universe of human proteins at neXtProt for RPS2: NX_P15880

Explore proteomics data for RPS2 at MOPED 

Post-translational modifications:

  • UniProtKB: Citrullinated by PADI4 in the Arg/Gly-rich region
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P15880

    • RPS2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RPS2 Protein Expression
    REFSEQ proteins: NP_002943.2  
    ENSEMBL proteins: 
     ENSP00000341885   ENSP00000436865   ENSP00000460860   ENSP00000436227   ENSP00000434846  
     ENSP00000436356   ENSP00000433170   ENSP00000433034   ENSP00000454837  
    Reactome Protein details: P15880
    Human Recombinant Protein Products for RPS2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for RPS2
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for RPS2
    GenScript Custom Purified and Recombinant Proteins Services for RPS2
    Novus Biologicals RPS2 Proteins
    Novus Biologicals RPS2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RPS2 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm IDA16061210
    GO:0005730NOT nucleolus IDA16061210
    GO:0005829cytosol TAS--
    GO:0005840ribosome ----
    GO:0015935small ribosomal subunit ----

    RPS2 for ontologies           About GeneDecksing



    RPS2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for RPS2
    OriGene Custom Antibody Services for RPS2
    GenScript Superior Antibodies for RPS2
    Novus Biologicals RPS2 Antibodies
    Abcam antibodies for RPS2
    Cloud-Clone Corp. Antibodies for RPS2 
    ThermoFisher Antibody for RPS2
    LSBio Antibodies in human, mouse, rat for RPS2 

    Assay Products for RPS2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RPS2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RPS2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RPS2 
    Cloud-Clone Corp. CLIAs for RPS2

    Protein Domains /
    Families
    for RPS2 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    RPS: S ribosomal proteins

    5/8 InterPro protein domains (see all 8):
     IPR005711 Ribosomal_S5_euk/arc
     IPR013810 Ribosomal_S5_N
     IPR014720 dsRNA-bd-like_dom
     IPR005324 Ribosomal_S5_C
     IPR020568 Ribosomal_S5_D2-typ_fold

    Graphical View of Domain Structure for InterPro Entry P15880

    ProtoNet protein and cluster: P15880

    2 Blocks protein domains:
    IPB000851 Ribosomal protein S5
    IPB011070 Globular protein


    UniProtKB/Swiss-Prot: RS2_HUMAN, P15880
    Similarity: Belongs to the ribosomal protein S5P family
    Similarity: Contains 1 S5 DRBM domain


    RPS2 for domains           About GeneDecksing


    Function
    for RPS2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:
         Genatlas biochemistry entry for RPS2:
    60S ribosomal protein S2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0003735structural constituent of ribosome IDA15883184
    GO:0005515protein binding IPI15473865
    GO:0017134fibroblast growth factor binding IPI16263090
         
    RPS2 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for RPS2:
     Cytoplasmic 40S maturation def  Decreased G3BP1 protein expres  Decreased Hepatitis C virus re  Increased cell death HMECs cel 
     Increased cell number in S  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RPS2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RPS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RPS2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RPS2 

    miRNA
    Products:            		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPS2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate RPS2
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RPS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RPS2
    Sirion Biotech Customized adenovirus for overexpression of RPS2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RPS2 (see all 7)
    OriGene ORF clones in mouse, rat for RPS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RPS2 (NM_002765)
    Sino Biological Human cDNA Clone for RPS2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS2
    Sirion Biotech Customized lentivirus for stable overexpression of RPS2 
                         Customized lentivirus expression plasmids for stable overexpression of RPS2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for RPS2
    Search LifeMap BioReagents cell lines for RPS2
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS2


    Pathways & Interactions
    for RPS2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RPS2 About   (see all 6)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Viral mRNA Translation
    		Influenza Life Cycle0.95
    		3' -UTR-mediated translational regulation0.93
    		Influenza Infection0.95
    		L13a-mediated translational silencing of Ceruloplasmin expression0.93
    		Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    		Formation of a pool of free 40S subunits0.90
    		Eukaryotic Translation Termination0.94
    		Nonsense-Mediated Decay0.84
    2Translation initiation complex formation
    		Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.95
    		Formation of the ternary complex, and subsequently, the 43S complex0.87
    		Ribosomal scanning and start codon recognition0.95
    		Translation initiation complex formation0.87
    3Metabolism of mRNA
    		Metabolism of mRNA0.92
    		Metabolism of RNA0.92
    4Generic Transcription Pathway
    		Gene Expression0.47
    5Asparagine N-linked glycosylation
    		Metabolism of proteins0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPS2
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPS2
        Cytoplasmic Ribosomal Proteins


    5/27        Reactome Pathways for RPS2 (see all 27)
        Formation of the ternary complex, and subsequently, the 43S complex
    Nonsense Mediated Decay Independent of the Exon Junction Complex
    Nonsense-Mediated Decay
    Translation
    SRP-dependent cotranslational protein targeting to membrane


    1         Kegg Pathway  (Kegg details for RPS2):
        Ribosome


    RPS2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RPS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/393 Interacting proteins for RPS2 (P158802, 3 ENSP000003418854) via UniProtKB, MINT, STRING, and/or I2D (see all 393)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPS15AP622442, 3, ENSP000003186464MINT-6542674 MINT-6489539 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=4 STRING: ENSP00000318646
    RPL11P629132, 3, ENSP000003636764MINT-6542674 MINT-6489539 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=3 STRING: ENSP00000363676
    RPS3P233962, 3, ENSP000002785724MINT-6542674 MINT-6489539 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=3 STRING: ENSP00000278572
    RPL6Q028782, 3, ENSP000002027734MINT-6542674 MINT-6489539 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=1 STRING: ENSP00000202773
    ENSG00000096150P622692, 3MINT-6541718 I2D: score=3 
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--
    GO:0006415translational termination TAS--

    RPS2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RPS2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RPS2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RPS2 (RS2)

    1 Novoseek inferred chemical compound relationship for RPS2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arginine 34.9 1 15473865 (1)

    Search CenterWatch for drugs/clinical trials and news about RPS2 / RS2

    Transcripts
    for RPS2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RPS2 gene: 
    NM_002952.3  

    Unigene Clusters for RPS2:

    Ribosomal protein S2
    Hs.356366  [show with all ESTs], Hs.381079  [show with all ESTs], Hs.498569  [show with all ESTs], Hs.506997  [show with all ESTs]
    Unigene Representative Sequences: BG165653, BM467031, BF972117, BM423570
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000343262(uc002cno.2) ENST00000526522 ENST00000526586 ENST00000533186
    ENST00000532746 ENST00000533872 ENST00000527109(uc002cnm.2) ENST00000527871
    ENST00000530225 ENST00000531065 ENST00000533161(uc002cnn.2) ENST00000529806
    ENST00000534461 ENST00000527302 ENST00000526908 ENST00000527826 ENST00000563194

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:             		 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPS2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate RPS2
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RPS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS2
    Clone
    Products:             		 OriGene clones in human, mouse for RPS2 (see all 7)
    OriGene ORF clones in mouse, rat for RPS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RPS2 (NM_002765)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS2
    Sirion Biotech Customized lentivirus for stable overexpression of RPS2 
                         Customized lentivirus expression plasmids for stable overexpression of RPS2 
    Primer
    Products:            		OriGene qPCR primer pairs and template standards for RPS2
    OriGene qSTAR qPCR primer pairs in human, mouse for RPS2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RPS2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS2

    Additional mRNA sequence: 

    AB082925.1 AL832857.1 BC001795.1 BC006559.2 BC008329.2 BC008862.2 BC010165.2 BC012354.1 
    BC013833.1 BC016178.1 BC016951.2 BC018993.2 BC019021.2 BC021545.1 BC023541.1 BC025677.1 
    BC029979.1 BC032129.2 BC035427.1 BC066321.1 BC068051.1 BC071673.1 BC071922.1 BC071923.1 
    BC071924.1 BC073966.1 BC075830.1 BC105985.1 BC106060.1 

    24/346 DOTS entries (see all 346):

    DT.95277449  DT.100640089  DT.100763615  DT.95277540  DT.100737773  DT.92411543  DT.100737906  DT.100737854 
    DT.100737763  DT.91940355  DT.97849492  DT.99926730  DT.100846786  DT.75177498  DT.92473920  DT.87010305 
    DT.97869804  DT.92473980  DT.99926712  DT.100737891  DT.92474003  DT.120702433  DT.97869788  DT.100737858 

    24/260 AceView cDNA sequences (see all 260):

    CR601170 CR610190 Y11158 BC068051 AB065088 BQ374822 CR608509 CR593005 
    BF871825 BF871025 CR591765 BC018993 CR607747 BG938536 CR613101 BM423994 
    CR613584 BC006559 CR594414 CN484452 CR617837 BC063011 BC004520 CR608202 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for RPS2 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c
    SP1:                                                        -                       -     -                                       
    SP2:                                                        -                       -                                             
    SP3:                                                        -                       -                                             
    SP4:                                                        -                                                                     
    SP5:                                                        -     -     -     -     -                                             


    ECgene alternative splicing isoforms for RPS2

    Expression
    for RPS2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPS2 expression in normal human tissues (normalized intensities)      RPS2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGCTGGTA
    RPS2 Expression
    About this image


    RPS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer
     
     Tonsil (Hematopoietic System)
     
     Prostate (Endocrine System)

    See RPS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPS2

    SOURCE GeneReport for Unigene clusters: Hs.356366 Hs.381079 Hs.498569 Hs.506997
        SABiosciences Custom PCR Arrays for RPS2
    Primer
    Products:    		OriGene qPCR primer pairs and template standards for RPS2
    OriGene qSTAR qPCR primer pairs in human, mouse for RPS2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RPS2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS2

    Orthologs
    for RPS2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPS2 gene from 10/29 species (see all 29)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rps21 , 5 ribosomal protein S21, 5 87.6(n)1
    98.63(a)1    		   17 (12.51 cM)5
    168981  NM_008503.51  NP_032529.21 
     247181165 
    chicken
    (Gallus gallus)    		 Aves RPS21 ribosomal protein S2 82.43(n)
    96.51(a)    		   416544  XM_414845.2  XP_414845.2 
    lizard
    (Anolis carolinensis)    		 Reptilia RPS26
    		 Uncharacterized protein
    		 94(a)
    		 1 ↔ 1
    		 GL344276.1(92072-101490)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.291552 Xenopus laevis transcribed sequence with moderate similarity more 86.94(n)    BQ897446.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufb65c082 wufb65c08 81.59(n)   322564  57070873 
    fruit fly
    (Drosophila melanogaster)    		 Insecta sop3
    RpS21    		 protein biosynthesis structural
    constituent of more3
    Ribosomal protein S21    		 83(a)3
    76.6(n)1
    84.31(a)1    		   30E13
    343091  NM_057526.41  NP_476874.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea rps-21 , 3 Protein RPS-21 78(a)3
    67.79(n)1
    75.19(a)1    		   IV(7925484-7926587)3
    1775831  NM_068921.41  NP_501322.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes RPS2(YGL123W)4
    RPS21    		 Protein component of the small (40S) subunit, essential more4
    Rps2p1    		 59.57(n)1
    62.13(a)1    		   7(277617-278381)4
    8527541, 4  NP_011392.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons XW61 40S ribosomal protein S2-1 66.02(n)
    75.29(a)    		   842207  NM_104618.2  NP_176134.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.110492 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 75.16(n)    AK064984.1 


    ENSEMBL Gene Tree for RPS2 (if available)
    TreeFam Gene Tree for RPS2 (if available)

    Paralogs
    for RPS2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPS2 gene
    4 SIMAP similar genes for RPS2 using alignment to 14 protein entries:     RS2_HUMAN (see all proteins):
    OK/KNS-cl.6    rps2    OK/KNS-cl.7    LOC392781

    RPS2 for paralogs           About GeneDecksing


    5/65 Pseudogenes.org Pseudogenes for RPS2 (see all 65)
    PGOHUM00000238600 PGOHUM00000242315 PGOHUM00000242471 PGOHUM00000250396 PGOHUM00000242617


    Genomic Variants
    for RPS2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    		Structural Variations
         Database of Genomic Variants (DGV) 10/16 variations for RPS2 (see all 16):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422427CNV Duplication17116639
    dgv2547n71CNV Loss21882294
    nsv833120CNV Loss17160897
    dgv2545n71CNV Loss21882294
    dgv2549n71CNV Loss21882294
    dgv2546n71CNV Loss21882294
    nsv905048CNV Loss21882294
    dgv2551n71CNV Loss21882294
    dgv2550n71CNV Loss21882294
    dgv2540n71CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RPS2
    DNA2.0 Custom Variant and Variant Library Synthesis for RPS2

    Disorders / Diseases
    for RPS2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 603624    OMIM disorders: --

    10 diseases for RPS2:    About MalaCards
    diamond-blackfan anemia    herpes simplex    astrocytoma    influenza
    anemia    pneumonia    adenoma    prostate cancer
    prostatitis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for RPS2:
    Diamond-Blackfan anemia

    RPS2 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for RPS2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 12694581 (1)
    cancer 0 1 17184759 (1)


    Export disorders for RPS2 gene to outside databases

    Publications
    for RPS2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPS2 gene, integrated from 9 sources (see all 101):
    (articles sorted by number of sources associating them with RPS2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Discovery of peptidylarginine deiminase-4 substrates by protein array: antagonistic citrullination and methylation of human ribosoma l protein S2. (PubMed id 21584310)1, 2 Guo Q....Fast W. (2011)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. A map of 75 human ribosomal protein genes. (PubMed id 9582194)1, 3 Kenmochi N.... Page D.C. (1998)
    4. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699)1, 2 Vladimirov S.N.... Otto A. (1996)
    5. Human cDNA sequence homologous to the mouse LLRep3 gene family. (PubMed id 2308862)1, 2 Slynn G.... Markham A.F. (1990)
    6. PRMT3 inhibits ubiquitination of ribosomal protein S2 and together forms an active enzyme complex. (PubMed id 18573314)1, 9 Choi S....Im D.S. (2008)
    7. Fibroblast growth factor 3, a protein with a dual subcellular fate, is interacting with human ribosomal protein S2. (PubMed id 16263090)1, 9 Antoine M....Kiefer P. (2005)
    8. Ribosomal protein S2 is a substrate for mammalian PRMT3 (protein arginine methyltransferase 3). (PubMed id 15473865)1, 9 Swiercz R....Bedford M.T. (2005)
    9. Identification of an unconventional nuclear localization signal in human ribosomal protein S2. (PubMed id 16061210)1, 9 Antoine M....Kiefer P. (2005)
    10. Identification of ribosomal proteins S2 and L10a as tumor antigens recognized by HLA-A26-restricted CTL. (PubMed id 12694581)1, 9 Koga M....Itoh K. (2003)

    External Searches for RPS2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RPS2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6187 HGNC: 10404 AceView: RPS2 Ensembl:ENSG00000140988 euGenes: HUgn6187
    ECgene: RPS2 Kegg: 6187 H-InvDB: RPS2

    Other Databases showing RPS2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RPS2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPS2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RPS2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RPS2 gene:
    Search GeneIP for patents involving RPS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for RPS2 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RPS2   OriGene RNAi products in human, mouse, rat for RPS2  
     OriGene qPCR primer pairs and template standards for RPS2   OriGene Protein Over-expression Lysate for RPS2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for RPS2  
     OriGene qSTAR qPCR primer pairs in human, mouse for RPS2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for RPS2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RPS2   OriGene Custom Protein Services for RPS2  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RPS2
     QIAGEN SeqTarget long-range PCR primers for resequencing RPS2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS2
     GenScript Custom Purified and Recombinant Proteins Services for RPS2 GenScript cDNA clones with any tag delivered in your preferred vector for RPS2
     GenScript Custom Assay Services for RPS2 GenScript Superior Antibodies for RPS2
     GenScript Custom overexpressing Cell Line Services for RPS2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RPS2 promoter
     Search Chromatin IP Primers for RPS2
     RT2 qPCR Primer Assay in human, mouse, rat RPS2
     GNC Network for RPS2
     SABiosciences Custom PCR Arrays for RPS2
     Search Tocris compounds for RPS2 (RS2)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for RPS2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RPS2 antibodies
     RPS2 proteins
     RPS2 lysates
     Antibodies for RPS2
     See all of Abcam's Antibodies, Kits and Proteins for RPS2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for RPS2
     Antibodies for RPS2
     ELISAs for RPS2
     CLIAs for RPS2
     Search LifeMap BioReagents cell lines for RPS2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS2
     Browse SwitchGear 3'UTR luciferase reporter plasmids for RPS2
     SwitchGear Promoter luciferase reporter plasmids for RPS2
     ThermoFisher Antibody for RPS2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for RPS2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RPS2
    Customized:
     lentivirus for stable overexpression of RPS2
     lentivirus expression plasmids for stable overexpression of RPS2
     adenovirus for overexpression of RPS2
     LSBio Antibodies in human, mouse, rat for RPS2
    		Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2014 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      RPS2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4