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RPS2 Gene(Protein Coding)

Ribosomal Protein S2

GCID:
GC16M001983
GIFtS:
61
Genes Participants
UDN Logo

Aliases for RPS2 Gene

Aliases for RPS2 Gene

  • Ribosomal Protein S2 2 3 5
  • 40S Ribosomal Protein S4 3 4
  • Protein LLRep3 3 4
  • OK/KNS-Cl.6 3
  • LLREP3 3
  • RPS4 4
  • S2 3

External Ids for RPS2 Gene

Previous GeneCards Identifiers for RPS2 Gene

  • GC16M002029
  • GC16M001952
  • GC16M002012
  • GC16M001967
  • GC16M001975

Summaries for RPS2 Gene

Entrez Gene Summary for RPS2 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S5P family of ribosomal proteins. It is located in the cytoplasm. This gene shares sequence similarity with mouse LLRep3. It is co-transcribed with the small nucleolar RNA gene U64, which is located in its third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS2 Gene

RPS2 (Ribosomal Protein S2) is a Protein Coding gene. Diseases associated with RPS2 include Diamond-Blackfan Anemia and Retroperitoneal Sarcoma. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. GO annotations related to this gene include poly(A) RNA binding and enzyme binding.

Gene Wiki entry for RPS2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS2 Gene

Genomics for RPS2 Gene

Products:

  1. Regulatory Element

Regulatory Elements for RPS2 Gene

Enhancers for RPS2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPS2 on UCSC Golden Path with GeneCards custom track

Promoters for RPS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPS2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the RPS2 gene promoter:

Genomic Location for RPS2 Gene

Chromosome:
16
Start:
1,962,052 bp from pter
End:
1,964,860 bp from pter
Size:
2,809 bases
Orientation:
Minus strand

Genomic View for RPS2 Gene

Genes around RPS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for RPS2 Gene

Proteins for RPS2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for RPS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15880-RS2_HUMAN
    Recommended name:
    40S ribosomal protein S2
    Protein Accession:
    P15880
    Secondary Accessions:
    • B2R5G0
    • D3DU82
    • Q3MIB1

    Protein attributes for RPS2 Gene

    Size:
    293 amino acids
    Molecular mass:
    31324 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA35078.1; Type=Frameshift; Positions=14, 27, 40, 46, 48, 52; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPS2 Gene

neXtProt entry for RPS2 Gene

Proteomics data for RPS2 Gene at MOPED

Protein Expression for RPS2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for RPS2 Gene

  • Asymmetric arginine dimethylation by PRMT3 occurs at multiple sites in the Arg/Gly-rich region.
  • Citrullinated by PADI4 in the Arg/Gly-rich region.
  • Ubiquitination at Lys 58, Lys 65, Lys 114, Lys 145, Lys 212, Lys 238, Lys 246, Lys 257, Lys 263, and Lys 275
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPS2 Gene

Domains & Families for RPS2 Gene

Gene Families for RPS2 Gene

HGNC:

Protein Domains for RPS2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RPS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P15880

UniProtKB/Swiss-Prot:

RS2_HUMAN :
  • Contains 1 S5 DRBM domain.
  • Belongs to the ribosomal protein S5P family.
Domain:
  • Contains 1 S5 DRBM domain.
Family:
  • Belongs to the ribosomal protein S5P family.
genes like me logo Genes that share domains with RPS2: view

Function for RPS2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for RPS2 Gene

GENATLAS Biochemistry:
60S ribosomal protein S2

Gene Ontology (GO) - Molecular Function for RPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003729 mRNA binding IDA 18464793
GO:0005515 protein binding IPI 15473865
genes like me logo Genes that share ontologies with RPS2: view

Phenotypes for RPS2 Gene

GenomeRNAi human phenotypes for RPS2:
genes like me logo Genes that share phenotypes with RPS2: view

miRNA for RPS2 Gene

miRTarBase miRNAs that target RPS2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS2 Gene

Localization for RPS2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS2 Gene COMPARTMENTS Subcellular localization image for RPS2 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
chloroplast 2
mitochondrion 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for RPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 NOT nucleolus IDA 16061210
GO:0005829 cytosol TAS --
GO:0015935 small ribosomal subunit IEA --
GO:0016020 membrane IDA 19946888
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with RPS2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS2 Gene

Pathways & Interactions for RPS2 Gene

SuperPathways for RPS2 Gene

PathCards logoMore details on SuperPathways for RPS2
Superpath Contained pathways
1 Viral mRNA Translation
Cap-dependent Translation Initiation
.94
Eukaryotic Translation Elongation
.94
Eukaryotic Translation Initiation
.94
GTP hydrolysis and joining of the 60S ribosomal subunit
.94
Peptide chain elongation
.94
L13a-mediated translational silencing of Ceruloplasmin expression
.93
Eukaryotic Translation Termination
.92
Selenocysteine synthesis
.92
Viral mRNA Translation
.92
Formation of a pool of free 40S subunits
.91
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
.91
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
.84
Nonsense-Mediated Decay (NMD)
.84
CFTR translational fidelity (class I mutations)
.82
Selenoamino acid metabolism
.79
Translation
.76
SRP-dependent cotranslational protein targeting to membrane
.75
Cytoplasmic Ribosomal Proteins
.66
Ribosome
.60
Metabolism of amino acids and derivatives
.33
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Formation of the ternary complex, and subsequently, the 43S complex
.88
Ribosomal scanning and start codon recognition
.88
Translation initiation complex formation
.88
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
.87
3 Influenza Viral RNA Transcription and Replication
Influenza Life Cycle
.94
Influenza Viral RNA Transcription and Replication
.94
Influenza Infection
.93
4 rRNA processing
Major pathway of rRNA processing in the nucleolus
.92
rRNA processing
.92
rRNA modification in the nucleus
.32
5 Infectious disease
Infectious disease
.64
Disease
.48
genes like me logo Genes that share pathways with RPS2: view

Gene Ontology (GO) - Biological Process for RPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006413 translational initiation TAS --
GO:0006415 translational termination TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPS2: view

No data available for SIGNOR curated interactions for RPS2 Gene

Drugs & Compounds for RPS2 Gene

Products:

  1. Drug

(1) Drugs for RPS2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with RPS2: view

Transcripts for RPS2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for RPS2 Gene

(1) REFSEQ mRNAs :
(40) Additional mRNA sequences :
(260) Selected AceView cDNA sequences:
(17) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RPS2 Gene

Ribosomal protein S2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c
SP1: - - -
SP2: - -
SP3: - -
SP4: -
SP5: - - - - -
SP6: - - -
SP7: - - -
SP8:
SP9: -
SP10: - - - - - -
SP11: -
SP12: -

Relevant External Links for RPS2 Gene

GeneLoc Exon Structure for
RPS2
ECgene alternative splicing isoforms for
RPS2

Expression for RPS2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for RPS2 Gene

mRNA expression in normal human tissues for RPS2 Gene
mRNA expression by BioGPS for RPS2 GenemRNA expression by GTEx for RPS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPS2 Gene

This gene is overexpressed in Nasal epithelium (6.9) and Tlymphocyte (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS2 Gene



SOURCE GeneReport for Unigene cluster for RPS2 Gene Hs.356366

genes like me logo Genes that share expression patterns with RPS2: view

Protein tissue co-expression partners for RPS2 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS2 Gene

Orthologs for RPS2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia RPS2 35
  • 89.65 (n)
  • 98.98 (a)
RPS2 36
  • 99 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia RPS2 35
  • 88.85 (n)
  • 99.32 (a)
RPS2 36
  • 84 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Rps2 35
  • 87.6 (n)
  • 98.63 (a)
Rps2 16
Rps2-ps6 36
  • 99 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia RPS2 35
  • 99.09 (n)
  • 100 (a)
rat
(Rattus norvegicus)
 Mammalia Rps2 35
  • 88.17 (n)
  • 98.63 (a)
oppossum
(Monodelphis domestica)
 Mammalia RPS2 36
  • 86 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia RPS2 36
  • 81 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves RPS2 35
  • 83.75 (n)
  • 98.33 (a)
RPS2 36
  • 97 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia RPS2 36
  • 94 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia rps2 35
  • 85 (n)
  • 96.67 (a)
Str.6712 35
African clawed frog
(Xenopus laevis)
 Amphibia Xl.29155 35
zebrafish
(Danio rerio)
 Actinopterygii rps2 35
  • 83.48 (n)
  • 96.58 (a)
wufb65c08 35
rps2 36
  • 94 (a)
 OneToOne
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.9009 35
fruit fly
(Drosophila melanogaster)
 Insecta sop 37
  • 83 (a)
RpS2 35
  • 77.09 (n)
  • 83.26 (a)
RpS2 36
  • 81 (a)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP003768 35
  • 75.6 (n)
  • 83.04 (a)
worm
(Caenorhabditis elegans)
 Secernentea rps-2 37
  • 78 (a)
rps-2 35
  • 70.61 (n)
  • 77.73 (a)
rps-2 36
  • 71 (a)
 OneToOne
A. gosspyii yeast
(Ashbya gossypii)
 Saccharomycetes AGOS_AAR177W 35
  • 64.44 (n)
  • 60 (a)
K. lactis yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0F09812g 35
  • 62.19 (n)
  • 62.04 (a)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes RPS2 35
  • 60.19 (n)
  • 61.57 (a)
RPS2 36
  • 58 (a)
 OneToOne
RPS2 38
thale cress
(Arabidopsis thaliana)
 eudicotyledons XW6 35
  • 66.82 (n)
  • 76.26 (a)
Alicante grape
(Vitis vinifera)
 eudicotyledons Vvi.7153 35
barley
(Hordeum vulgare)
 Liliopsida Hv.4103 35
rice
(Oryza sativa)
 Liliopsida Os.11049 35
Os03g0807800 35
  • 72.4 (n)
  • 71.49 (a)
wheat
(Triticum aestivum)
 Liliopsida Ta.28855 35
corn
(Zea mays)
 Liliopsida Zm.7140 35
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.4371 35
bread mold
(Neurospora crassa)
 Ascomycetes NCU06047 35
  • 70.32 (n)
  • 69.86 (a)
fission yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes rps2 35
  • 65.33 (n)
  • 67.56 (a)
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.10600 36
  • 81 (a)
 OneToOne
Species with no ortholog for RPS2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPS2 Gene

ENSEMBL:
Gene Tree for RPS2 (if available)
TreeFam:
Gene Tree for RPS2 (if available)

Paralogs for RPS2 Gene

(4) SIMAP similar genes for RPS2 Gene using alignment to 14 proteins:

Pseudogenes.org Pseudogenes for RPS2 Gene

genes like me logo Genes that share paralogs with RPS2: view

No data available for Paralogs for RPS2 Gene

Variants for RPS2 Gene

Structural Variations from Database of Genomic Variants (DGV) for RPS2 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
dgv2540n71 CNV Loss 21882294
dgv2544n71 CNV Loss 21882294
dgv2545n71 CNV Loss 21882294
nsv833120 CNV Loss 17160897
nsv905048 CNV Loss 21882294
dgv2546n71 CNV Loss 21882294
dgv2547n71 CNV Loss 21882294
dgv2548n71 CNV Gain 21882294
dgv2549n71 CNV Loss 21882294
dgv2550n71 CNV Loss 21882294
nsv905061 CNV Loss 21882294
dgv2551n71 CNV Loss 21882294
nsv471070 CNV Gain 18288195
nsv905070 CNV Gain+Loss 21882294
dgv2552n71 CNV Gain+Loss 21882294

Variation tolerance for RPS2 Gene

Residual Variation Intolerance Score: 35.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 8.03% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for RPS2 Gene

Disorders for RPS2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RPS2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
diamond-blackfan anemia
  • blackfan - diamond syndrome
retroperitoneal sarcoma
- elite association - COSMIC cancer census association via MalaCards
Search RPS2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RPS2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPS2
genes like me logo Genes that share disorders with RPS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS2 Gene

Publications for RPS2 Gene

  1. Ribosomal protein S2 is a substrate for mammalian PRMT3 (protein arginine methyltransferase 3). (PMID: 15473865) Swiercz R. … Bedford M.T. (Biochem. J. 2005) 3 4 23 67
  2. PRMT3 inhibits ubiquitination of ribosomal protein S2 and together forms an active enzyme complex. (PMID: 18573314) Choi S. … Im D.S. (Biochim. Biophys. Acta 2008) 3 23
  3. Identification of an unconventional nuclear localization signal in human ribosomal protein S2. (PMID: 16061210) Antoine M. … Kiefer P. (Biochem. Biophys. Res. Commun. 2005) 3 23
  4. Fibroblast growth factor 3, a protein with a dual subcellular fate, is interacting with human ribosomal protein S2. (PMID: 16263090) Antoine M. … Kiefer P. (Biochem. Biophys. Res. Commun. 2005) 3 23
  5. Identification of ribosomal proteins S2 and L10a as tumor antigens recognized by HLA-A26-restricted CTL. (PMID: 12694581) Koga M. … Itoh K. (Tissue Antigens 2003) 3 23

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