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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RPS2 Gene

protein-coding GIFtS: 62
GCID: GC16M002012

ribosomal protein S2

Explore 10 diseases affiliated with
RPS2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ribosomal Protein S2¹ ²		40S Ribosomal Protein S4² ³
LLREP3¹ ²		40S Ribosomal Protein S2²
S2¹ ²		OK/KNS-Cl.6¹
Protein LLRep3² ³		RPS4³

External Ids:	HGNC: 10404¹	Entrez Gene: 6187²	Ensembl: ENSG00000140988⁷	OMIM: 603624⁵	UniProtKB: P15880³

Export aliases for RPS2 gene to outside databases

Previous GC identifers: GC16M002029 GC16M001952

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RPS2:

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.

Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene

encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S5P family of ribosomal

proteins. It is located in the cytoplasm. This gene shares sequence similarity with mouse LLRep3. It is co-transcribed

with the small nucleolar RNA gene U64, which is located in its third intron. As is typical for genes encoding

ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. (provided by

RefSeq, Jul 2008)

Gene Wiki entry for RPS2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RPS2 gene promoter:
SRF NF-1 NF-1/L AML1a MAZR Pax-5 SRF (504 AA) AP-4 YY1 STAT3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RPS2 promoter sequence

Search SABiosciences Chromatin IP Primers for RPS2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3

RPS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS2 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M002012: view genomic region (about GC identifiers)

Start:	2,012,053 bp from pter	End:	2,014,861 bp from pter
Size:	2,809 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RS2_HUMAN, P15880 (See protein sequence)

Recommended Name: 40S ribosomal protein S2

Size: 293 amino acids; 31324 Da

Sequence caution: Sequence=CAA35078.1; Type=Frameshift; Positions=14, 27, 40, 46, 48, 52;

Secondary accessions: B2R5G0 D3DU82 Q3MIB1

Explore the universe of human proteins at neXtProt for RPS2: NX_P15880

Post-translational modifications:

Citrullinated by PADI4 in the Arg/Gly-rich region¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P15880

RPS2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002943.2

ENSEMBL proteins:

ENSP00000341885 ENSP00000436865 ENSP00000460860 ENSP00000436227 ENSP00000434846

ENSP00000436356 ENSP00000433170 ENSP00000433034 ENSP00000454837

Reactome Protein details: P15880
Human Recombinant Protein Products for RPS2:

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	Uscn Proteins for RPS2

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005654	nucleoplasm	IDA	16263090
GO:0005730	NOT nucleolus	IDA	16263090
GO:0005829	cytosol	TAS	--
GO:0005840	ribosome	--	--
GO:0015935	small ribosomal subunit	--	--

RPS2 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for RPS2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RPS2 for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR005711 Ribosomal_S5_euk/arc

IPR013810 Ribosomal_S5_N

IPR014720 dsRNA-bd-like_dom

IPR005324 Ribosomal_S5_C

IPR020568 Ribosomal_S5_D2-typ_fold

Graphical View of Domain Structure for InterPro Entry P15880

ProtoNet protein and cluster: P15880

2 Blocks protein families:

IPB000851 Ribosomal protein S5

IPB011070 Globular protein

UniProtKB/Swiss-Prot: RS2_HUMAN, P15880

Similarity: Belongs to the ribosomal protein S5P family

Similarity: Contains 1 S5 DRBM domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

Genatlas biochemistry entry for RPS2:

60S ribosomal protein S2

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003723	RNA binding	IEA	--
GO:0003735	structural constituent of ribosome	IDA	15883184
GO:0005515	protein binding	IPI	15473865
GO:0017134	fibroblast growth factor binding	IPI	16263090

RPS2 for ontologies About GeneDecksing

Phenotypes:
6 GenomeRNAi human phenotypes for RPS2:

Cytoplasmic 40S maturation def	Decreased G3BP1 protein expres	Decreased Hepatitis C virus re	Increased cell death HMECs cel
Increased cell number in S	Increased gamma-H2AX phosphory

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RPS2

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In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RPS2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Synthesis of PB1-F2

8/26 pathways (see all 26)
Viral Protein Synthesis	1.00	Cytoplasmic Ribosomal Proteins	0.86
Viral mRNA Translation	1.00	CFTR translational fidelity (class I mutations)	0.83
Influenza Viral RNA Transcription and Replication	1.00	SMG6 Cleaves mRNA with Premature Termination Codon	0.80
Synthesis of nascent polypeptide containing signal sequence	1.00	L13a-mediated translational silencing of Ceruloplasmin expression	0.79

Translation initiation complex formation

	Translation initiation complex formation	1.00			Ribosomal scanning and start codon recognition	0.96
	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	0.98			Formation of the ternary complex, and subsequently, the 43S complex	0.87

Metabolism of mRNA

Metabolism of mRNA

1.00

Metabolism of RNA

0.92

Disease

Disease

1.00

Generic Transcription Pathway

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

1 GeneGo (Thomson Reuters) Pathway for RPS2

CFTR translational fidelity (class I mutations)

1 BioSystems Pathway for RPS2

Cytoplasmic Ribosomal Proteins

5/32 Reactome Pathways for RPS2 (see all 32)

	Formation of a pool of free 40S subunits
	Synthesis of PB1-F2
	SMG6 Cleaves mRNA with Premature Termination Codon
	Influenza Life Cycle
	Viral mRNA Translation

1 Kegg Pathway (Kegg details for RPS2):

Ribosome

RPS2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RPS2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/388 Interacting proteins for RPS2 (P15880^{2, 3} ENSP00000341885⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 388)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RPS15A	P62244²^,³, ENSP00000318646⁴	MINT-6542674 MINT-6489539 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=4 STRING: ENSP00000318646
RPL11	P62913²^,³, ENSP00000363676⁴	MINT-6542674 MINT-6489539 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=3 STRING: ENSP00000363676
RPS3	P23396²^,³, ENSP00000278572⁴	MINT-6542674 MINT-6489539 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=3 STRING: ENSP00000278572
RPL6	Q02878²^,³, ENSP00000202773⁴	MINT-6542674 MINT-6489539 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=1 STRING: ENSP00000202773
RPL26	P61254²^,³	MINT-6542674 MINT-6489539 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=2

About this table

Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS	--
GO:0006412	translation	TAS	--
GO:0006413	translational initiation	TAS	--
GO:0006414	translational elongation	TAS	--
GO:0006415	translational termination	TAS	--

RPS2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RPS2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RPS2
1 Novoseek chemical compound relationship for RPS2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
arginine	34.9	1	15473865 (1)

Search CenterWatch for drugs/clinical trials and news about RPS2 / RS2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RPS2 gene:

NM_002952.3

Unigene Clusters for RPS2:

Ribosomal protein S2

Hs.356366 [show with all ESTs], Hs.381079 [show with all ESTs], Hs.498569 [show with all ESTs], Hs.506997 [show with all ESTs]

Unigene Representative Sequences: BG165653, BM467031, BF972117, BM423570

18 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000343262(uc002cno.2) ENST00000526522 ENST00000526586 ENST00000533186

ENST00000532746 ENST00000533872 ENST00000527109(uc002cnm.2) ENST00000527871

ENST00000530225 ENST00000531065 ENST00000533161(uc002cnn.2) ENST00000529806

ENST00000534461 ENST00000531182 ENST00000527302 ENST00000526908 ENST00000527826

ENST00000563194

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Additional cDNA sequence:

AB082925.1 AL832857.1 BC001795.1 BC006559.2 BC008329.2 BC008862.2 BC010165.2 BC012354.1

BC013833.1 BC016178.1 BC016951.2 BC018993.2 BC019021.2 BC021545.1 BC023541.1 BC025677.1

BC029979.1 BC032129.2 BC035427.1 BC066321.1 BC068051.1 BC071673.1 BC071922.1 BC071923.1

BC071924.1 BC073966.1 BC075830.1 BC105985.1 BC106060.1

24/351 DOTS entries (see all 351):

DT.95277449 DT.100640089 DT.100763615 DT.100737773 DT.92411543 DT.95277540 DT.100737906 DT.100737854

DT.100737763 DT.91940355 DT.75177498 DT.99926730 DT.97849492 DT.92473920 DT.100846786 DT.87010305

DT.92473980 DT.100737891 DT.99926712 DT.97869804 DT.92474003 DT.120702433 DT.97869788 DT.100737858

24/260 AceView cDNA sequences (see all 260):

CR605226 CR620130 CR606602 CR624847 CR612811 BG876857 CR596231 CR607006

CR607612 CR622407 AI971893 CR609604 AB065089 BC063011 CR608202 BC004520

CR617837 CN484452 CR613584 CR601170 CR593005 CR594414 BC006559 CR590936

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for RPS2 (see all 12) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	·	1g	^	2	^	3a	·	3b	·	3c	·	3d	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	^	7a	·	7b	·	7c
SP1:																			-								-		-
SP2:																			-								-
SP3:																			-								-
SP4:																			-
SP5:																			-		-		-		-		-

ECgene alternative splicing isoforms for RPS2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RPS2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGGCTGGTA

About this image

RPS2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Endoderm-like cells (Generation of hepato...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RPS2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RPS2

SOURCE GeneReport for Unigene clusters: Hs.356366 Hs.381079 Hs.498569 Hs.506997

SABiosciences Custom PCR Arrays for RPS2

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In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RPS2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for RPS2 gene from 11/46 species (see all 46) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rps2^{1 , 5}	ribosomal protein S2^{1, 5}	87.6(n)¹ 98.63(a)¹		17 (12.51 cM)⁵ 16898¹ NM_008503.5¹ NP_032529.2¹ 24718116⁵
chicken (Gallus gallus)	Aves	RPS2¹	ribosomal protein S2	82.43(n) 96.51(a)		416544 XM_414845.2 XP_414845.2
lizard (Anolis carolinensis)	Reptilia	RPS2⁶ MRPS5⁶	--	94(a) 9(a)	1 ↔ 1 possible ortholog	GL344276.1(92075-96934) 1(252872478-252911788)
African clawed frog (Xenopus laevis)	Amphibia	Xl.29155²	Xenopus laevis transcribed sequence with moderate similarity more	86.94(n)		BQ897446.1
zebrafish (Danio rerio)	Actinopterygii	wufb65c08²	wufb65c08	81.59(n)		322564 57070873
fruit fly (Drosophila melanogaster)	Insecta	sop³ RpS2¹	protein biosynthesis structural constituent of more³ Ribosomal protein S2¹	83(a)³ 76.6(n)¹ 84.31(a)¹		30E1³ 34309¹ NM_057526.4¹ NP_476874.1¹
worm (Caenorhabditis elegans)	Secernentea	rps-2^{1 , 3}	Protein RPS-2¹	78(a)³ 67.79(n)¹ 75.19(a)¹		IV(7925484-7926587)³ 177583¹ NM_068921.4¹ NP_501322.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	RPS2(YGL123W)⁴ RPS2¹	Protein component of the small (40S) subunit, essential more⁴ Rps2p¹	59.57(n)¹ 62.13(a)¹		7(277617-278381)⁴ 852754^{1, 4} NP_011392.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	XW6¹	40S ribosomal protein S2-1	66.02(n) 75.29(a)		842207 NM_104618.2 NP_176134.1
rice (Oryza sativa)	Liliopsida	Os.11049²	Oryza sativa (japonica cultivar-group) cDNA cloneJ more	75.16(n)		AK064984.1

ENSEMBL Gene Tree for RPS2 (if available)
TreeFam Gene Tree for RPS2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RPS2 gene

4 SIMAP similar genes for RPS2 using alignment to 14 protein entries: RS2_HUMAN (see all proteins):

OK/KNS-cl.6 rps2 OK/KNS-cl.7 LOC392781

RPS2 for paralogs About GeneDecksing

5/65 Pseudogenes.org Pseudogenes for RPS2 (see all 65)
PGOHUM00000238600 PGOHUM00000242315 PGOHUM00000242471 PGOHUM00000250396 PGOHUM00000242617

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs140705705^1,2	C,F	--	2012499(+)	`CTACCG/AAAGTT`	4	/F	us2k¹ ds500¹ syn¹		1		NA	3104
rs146634856^1,2	C	--	2012520(+)	`GCAGTG/ACAGCC`	4	/C	us2k¹ ds500¹ syn¹		2		NS EU	1471
rs145914766^1,2	C,F	--	2012547(+)	`CAGTCA/GTCGAT`	4	D	syn¹ us2k¹ ds500¹		1		NA	2816
rs138203888^1,2	F	--	2012595(+)	`GAGACG/AATGCC`	4	/I	ds500¹ us2k¹ syn¹		1		NA	3186
rs112659495^1,2	C,F	--	2012598(+)	`ACGATG/ACCAGT`	4	/G	syn¹ ds500¹ us2k¹		4		NA NS EU	4517
rs143347500^1,2	C,F	--	2012677(+)	`AGTCAG/AGAGAC`	3	--	ds500¹ us2k¹ int¹		2		NS EU	283
rs144474496^1,2		--	2012708(+)	`CCCACA/GGCAGG`	3	--	int¹ ds500¹ us2k¹		0	--	--	--	--
rs200947241^1,2		--	2012755(+)	`GTGTGA/GGGCTT`	4	P	syn¹ ds500¹ us2k¹		0	--	--	--	--
rs143242490^1,2	F	--	2012794(+)	`CGCACG/AGGGAC`	4	/P	syn¹ us2k¹ ds500¹		1		NA	2984
rs201628829^1,2		--	2012885(+)	`GGCCAC/TTGTAG`	4	N S	mis¹ ds500¹ us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for RPS2 (2012053 - 2014861 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for RPS2
3 CNVs: 5329 29656 4917

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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RPS2 for disorders           About GeneDecksing

OMIM gene information: 603624    OMIM disorders: --

10 diseases for RPS2:    About MalaCards

diamond-blackfan anemia herpes simplex anemia astrocytoma

prostate cancer breast cancer adenoma prostatitis

malaria carcinoma

1 disease from the University of Copenhagen DISEASES database for RPS2:

Diamond-Blackfan anemia

2 Novoseek disease relationships for RPS2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	1	12694581 (1)
cancer	0	1	17184759 (1)

Export disorders for RPS2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RPS2 gene, integrated from 9 sources (see all 85):
(articles sorted by number of sources associating them with RPS2)

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Discovery of peptidylarginine deiminase-4 substrates by protein array: antagonistic citrullination and methylation of human ribosoma l protein S2. (PubMed id 21584310)^{1, 2} Guo Q....Fast W. (2011)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A map of 75 human ribosomal protein genes. (PubMed id 9582194)^{1, 3} Kenmochi N.... Page D.C. (1998)
Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699)^{1, 2} Vladimirov S.N.... Otto A. (1996)
Human cDNA sequence homologous to the mouse LLRep3 gene family. (PubMed id 2308862)^{1, 2} Slynn G.... Markham A.F. (1990)
PRMT3 inhibits ubiquitination of ribosomal protein S2 and together forms an active enzyme complex. (PubMed id 18573314)^{1, 9} Choi S....Im D.S. (2008)
Fibroblast growth factor 3, a protein with a dual subcellular fate, is interacting with human ribosomal protein S2. (PubMed id 16263090)^{1, 9} Antoine M....Kiefer P. (2005)
Ribosomal protein S2 is a substrate for mammalian PRMT3 (protein arginine methyltransferase 3). (PubMed id 15473865)^{1, 9} Swiercz R....Bedford M.T. (2005)
Identification of an unconventional nuclear localization signal in human ribosomal protein S2. (PubMed id 16061210)^{1, 9} Antoine M....Kiefer P. (2005)
Identification of ribosomal proteins S2 and L10a as tumor antigens recognized by HLA-A26-restricted CTL. (PubMed id 12694581)^{1, 9} Koga M....Itoh K. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6187	HGNC: 10404	AceView: RPS2	Ensembl:ENSG00000140988	euGenes: HUgn6187
ECgene: RPS2	Kegg: 6187	H-InvDB: RPS2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RPS2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RPS2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for RPS2 gene:
Search GeneIP for patents involving RPS2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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ribosomal protein S2

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