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Aliases for RPS2 Gene

Aliases for RPS2 Gene

  • Ribosomal Protein S2 2 3 5
  • 40S Ribosomal Protein S4 3 4
  • Protein LLRep3 3 4
  • 40S Ribosomal Protein S2 3
  • OK/KNS-Cl.6 3
  • LLREP3 3
  • RPS4 4
  • S2 3

External Ids for RPS2 Gene

Previous GeneCards Identifiers for RPS2 Gene

  • GC16M002029
  • GC16M001952
  • GC16M002012
  • GC16M001967
  • GC16M001975
  • GC16M001983

Summaries for RPS2 Gene

Entrez Gene Summary for RPS2 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S5P family of ribosomal proteins. It is located in the cytoplasm. This gene shares sequence similarity with mouse LLRep3. It is co-transcribed with the small nucleolar RNA gene U64, which is located in its third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS2 Gene

RPS2 (Ribosomal Protein S2) is a Protein Coding gene. Diseases associated with RPS2 include Diamond-Blackfan Anemia. Among its related pathways are Viral mRNA Translation and Transport to the Golgi and subsequent modification. GO annotations related to this gene include poly(A) RNA binding and enzyme binding.

Gene Wiki entry for RPS2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS2 Gene

Genomics for RPS2 Gene

Regulatory Elements for RPS2 Gene

Enhancers for RPS2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around RPS2 on UCSC Golden Path with GeneCards custom track

Promoters for RPS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for RPS2 Gene

1,962,052 bp from pter
1,964,860 bp from pter
2,809 bases
Minus strand

Genomic View for RPS2 Gene

Genes around RPS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS2 Gene

Proteins for RPS2 Gene

  • Protein details for RPS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    40S ribosomal protein S2
    Protein Accession:
    Secondary Accessions:
    • B2R5G0
    • D3DU82
    • Q3MIB1

    Protein attributes for RPS2 Gene

    293 amino acids
    Molecular mass:
    31324 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAA35078.1; Type=Frameshift; Positions=14, 27, 40, 46, 48, 52; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPS2 Gene

neXtProt entry for RPS2 Gene

Post-translational modifications for RPS2 Gene

  • Asymmetric arginine dimethylation by PRMT3 occurs at multiple sites in the Arg/Gly-rich region.
  • Citrullinated by PADI4 in the Arg/Gly-rich region.
  • Ubiquitination at Lys 58, Lys 65, Lys 114, Lys 145, Lys 212, Lys 238, Lys 246, Lys 257, Lys 263, and Lys 275
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPS2 Gene

Domains & Families for RPS2 Gene

Gene Families for RPS2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 S5 DRBM domain.
  • Belongs to the ribosomal protein S5P family.
  • Contains 1 S5 DRBM domain.
  • Belongs to the ribosomal protein S5P family.
genes like me logo Genes that share domains with RPS2: view

Function for RPS2 Gene

Molecular function for RPS2 Gene

GENATLAS Biochemistry:
60S ribosomal protein S2

Gene Ontology (GO) - Molecular Function for RPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003729 mRNA binding IDA 18464793
GO:0003735 structural constituent of ribosome IDA 15883184
GO:0005515 protein binding IPI 15473865
GO:0017134 fibroblast growth factor binding IPI 16263090
GO:0019899 enzyme binding IPI 18573314
genes like me logo Genes that share ontologies with RPS2: view
genes like me logo Genes that share phenotypes with RPS2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS2 Gene

Localization for RPS2 Gene

Subcellular locations from

Jensen Localization Image for RPS2 Gene COMPARTMENTS Subcellular localization image for RPS2 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
chloroplast 2
mitochondrion 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for RPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005730 NOT nucleolus IDA 16061210
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RPS2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS2 Gene

Pathways & Interactions for RPS2 Gene

SuperPathways for RPS2 Gene

Superpath Contained pathways
1 Viral mRNA Translation
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing
5 Infectious disease
genes like me logo Genes that share pathways with RPS2: view

Gene Ontology (GO) - Biological Process for RPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IC 8706699
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPS2: view

No data available for SIGNOR curated interactions for RPS2 Gene

Drugs & Compounds for RPS2 Gene

(1) Drugs for RPS2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with RPS2: view

Transcripts for RPS2 Gene

Unigene Clusters for RPS2 Gene

Ribosomal protein S2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c
SP1: - - -
SP2: - -
SP3: - -
SP4: -
SP5: - - - - -
SP6: - - -
SP7: - - -
SP9: -
SP10: - - - - - -
SP11: -
SP12: -

Relevant External Links for RPS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS2 Gene

mRNA expression in normal human tissues for RPS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPS2 Gene

This gene is overexpressed in Nasal epithelium (6.9) and Tlymphocyte (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPS2 Gene

Protein tissue co-expression partners for RPS2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS2 Gene:


SOURCE GeneReport for Unigene cluster for RPS2 Gene:

genes like me logo Genes that share expression patterns with RPS2: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS2 Gene

Orthologs for RPS2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPS2 34
  • 89.65 (n)
  • 98.98 (a)
RPS2 35
  • 99 (a)
(Canis familiaris)
Mammalia RPS2 34
  • 88.85 (n)
  • 99.32 (a)
RPS2 35
  • 84 (a)
(Mus musculus)
Mammalia Rps2 34
  • 87.6 (n)
  • 98.63 (a)
Rps2 16
Rps2-ps6 35
  • 99 (a)
(Pan troglodytes)
Mammalia RPS2 34
  • 99.09 (n)
  • 100 (a)
(Rattus norvegicus)
Mammalia Rps2 34
  • 88.17 (n)
  • 98.63 (a)
(Monodelphis domestica)
Mammalia RPS2 35
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia RPS2 35
  • 81 (a)
(Gallus gallus)
Aves RPS2 34
  • 83.75 (n)
  • 98.33 (a)
RPS2 35
  • 97 (a)
(Anolis carolinensis)
Reptilia RPS2 35
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rps2 34
  • 85 (n)
  • 96.67 (a)
Str.6712 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.29155 34
(Danio rerio)
Actinopterygii rps2 34
  • 83.48 (n)
  • 96.58 (a)
wufb65c08 34
rps2 35
  • 94 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9009 34
fruit fly
(Drosophila melanogaster)
Insecta sop 36
  • 83 (a)
RpS2 34
  • 77.09 (n)
  • 83.26 (a)
RpS2 35
  • 81 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003768 34
  • 75.6 (n)
  • 83.04 (a)
(Caenorhabditis elegans)
Secernentea rps-2 36
  • 78 (a)
rps-2 34
  • 70.61 (n)
  • 77.73 (a)
rps-2 35
  • 71 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR177W 34
  • 64.44 (n)
  • 60 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F09812g 34
  • 62.19 (n)
  • 62.04 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS2 34
  • 60.19 (n)
  • 61.57 (a)
RPS2 35
  • 58 (a)
RPS2 37
thale cress
(Arabidopsis thaliana)
eudicotyledons XW6 34
  • 66.82 (n)
  • 76.26 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7153 34
(Hordeum vulgare)
Liliopsida Hv.4103 34
(Oryza sativa)
Liliopsida Os.11049 34
Os03g0807800 34
  • 72.4 (n)
  • 71.49 (a)
(Triticum aestivum)
Liliopsida Ta.28855 34
(Zea mays)
Liliopsida Zm.7140 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4371 34
bread mold
(Neurospora crassa)
Ascomycetes NCU06047 34
  • 70.32 (n)
  • 69.86 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps2 34
  • 65.33 (n)
  • 67.56 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10600 35
  • 81 (a)
Species where no ortholog for RPS2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPS2 Gene

Gene Tree for RPS2 (if available)
Gene Tree for RPS2 (if available)

Paralogs for RPS2 Gene

genes like me logo Genes that share paralogs with RPS2: view

No data available for Paralogs for RPS2 Gene

Variants for RPS2 Gene

Structural Variations from Database of Genomic Variants (DGV) for RPS2 Gene

Variant ID Type Subtype PubMed ID
dgv4858n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
nsv1160329 CNV deletion 26073780
nsv471070 CNV gain 18288195
nsv571179 CNV loss 21841781
nsv833120 CNV loss 17160897
nsv952901 CNV deletion 24416366
nsv984249 CNV duplication 23825009

Variation tolerance for RPS2 Gene

Residual Variation Intolerance Score: 35.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 8.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for RPS2 Gene

Disorders for RPS2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPS2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
diamond-blackfan anemia
  • diamond-blackfan anemia 1
- elite association - COSMIC cancer census association via MalaCards
Search RPS2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RPS2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RPS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS2 Gene

Publications for RPS2 Gene

  1. Ribosomal protein S2 is a substrate for mammalian PRMT3 (protein arginine methyltransferase 3). (PMID: 15473865) Swiercz R. … Bedford M.T. (Biochem. J. 2005) 3 4 22 65
  2. Discovery of peptidylarginine deiminase-4 substrates by protein array: antagonistic citrullination and methylation of human ribosomal protein S2. (PMID: 21584310) Guo Q. … Fast W. (Mol. Biosyst. 2011) 3 4 65
  3. PRMT3 inhibits ubiquitination of ribosomal protein S2 and together forms an active enzyme complex. (PMID: 18573314) Choi S. … Im D.S. (Biochim. Biophys. Acta 2008) 3 22 65
  4. Identification of an unconventional nuclear localization signal in human ribosomal protein S2. (PMID: 16061210) Antoine M. … Kiefer P. (Biochem. Biophys. Res. Commun. 2005) 3 22 65
  5. Fibroblast growth factor 3, a protein with a dual subcellular fate, is interacting with human ribosomal protein S2. (PMID: 16263090) Antoine M. … Kiefer P. (Biochem. Biophys. Res. Commun. 2005) 3 22 65

Products for RPS2 Gene

Sources for RPS2 Gene

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