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Aliases for RPS19BP1 Gene

Aliases for RPS19BP1 Gene

  • Ribosomal Protein S19 Binding Protein 1 2 3 5
  • 40S Ribosomal Protein S19-Binding Protein 1 3 4
  • RPS19-Binding Protein 1 3 4
  • S19BP 3 4
  • AROS 3 4
  • Homolog Of Mouse S19 Binding Protein 3

External Ids for RPS19BP1 Gene

Previous GeneCards Identifiers for RPS19BP1 Gene

  • GC22M038255
  • GC22M039925
  • GC22M022889
  • GC22M039563
  • GC22M039839

Summaries for RPS19BP1 Gene

GeneCards Summary for RPS19BP1 Gene

RPS19BP1 (Ribosomal Protein S19 Binding Protein 1) is a Protein Coding gene. Among its related pathways are Cellular response to heat stress and Cellular Senescence. GO annotations related to this gene include poly(A) RNA binding and enzyme binding.

UniProtKB/Swiss-Prot for RPS19BP1 Gene

  • Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS19BP1 Gene

Genomics for RPS19BP1 Gene

Regulatory Elements for RPS19BP1 Gene

Enhancers for RPS19BP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPS19BP1 on UCSC Golden Path with GeneCards custom track

Promoters for RPS19BP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPS19BP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPS19BP1 Gene

39,529,093 bp from pter
39,532,855 bp from pter
3,763 bases
Minus strand

Genomic View for RPS19BP1 Gene

Genes around RPS19BP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS19BP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS19BP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS19BP1 Gene

Proteins for RPS19BP1 Gene

  • Protein details for RPS19BP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Active regulator of SIRT1
    Protein Accession:
    Secondary Accessions:
    • B0QY96
    • Q5JZA1

    Protein attributes for RPS19BP1 Gene

    136 amino acids
    Molecular mass:
    15434 Da
    Quaternary structure:
    • Interacts with RPS19 (By similarity). Interacts with SIRT1.

neXtProt entry for RPS19BP1 Gene

Proteomics data for RPS19BP1 Gene at MOPED

Post-translational modifications for RPS19BP1 Gene

Other Protein References for RPS19BP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RPS19BP1 Gene

Domains & Families for RPS19BP1 Gene

Protein Domains for RPS19BP1 Gene


Suggested Antigen Peptide Sequences for RPS19BP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AROS family.
  • Belongs to the AROS family.
genes like me logo Genes that share domains with RPS19BP1: view

No data available for Gene Families for RPS19BP1 Gene

Function for RPS19BP1 Gene

Molecular function for RPS19BP1 Gene

UniProtKB/Swiss-Prot Function:
Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity.

Gene Ontology (GO) - Molecular Function for RPS19BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17964266
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPS19BP1: view

Phenotypes for RPS19BP1 Gene

genes like me logo Genes that share phenotypes with RPS19BP1: view

Animal Models for RPS19BP1 Gene

MGI Knock Outs for RPS19BP1:

Animal Model Products

CRISPR Products

miRNA for RPS19BP1 Gene

miRTarBase miRNAs that target RPS19BP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RPS19BP1 Gene

Localization for RPS19BP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS19BP1 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for RPS19BP1 Gene COMPARTMENTS Subcellular localization image for RPS19BP1 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for RPS19BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IEA,ISS 16289379
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with RPS19BP1: view

Pathways & Interactions for RPS19BP1 Gene

genes like me logo Genes that share pathways with RPS19BP1: view

Pathways by source for RPS19BP1 Gene

Gene Ontology (GO) - Biological Process for RPS19BP1 Gene


No data available for SIGNOR curated interactions for RPS19BP1 Gene

Drugs & Compounds for RPS19BP1 Gene

No Compound Related Data Available

Transcripts for RPS19BP1 Gene

Unigene Clusters for RPS19BP1 Gene

Ribosomal protein S19 binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPS19BP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d
SP1: - -
SP2: - - -
SP3: - - -
SP5: - - -

Relevant External Links for RPS19BP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS19BP1 Gene

mRNA expression in normal human tissues for RPS19BP1 Gene

Protein differential expression in normal tissues from HIPED for RPS19BP1 Gene

This gene is overexpressed in Lung (28.3) and Breast (25.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS19BP1 Gene

SOURCE GeneReport for Unigene cluster for RPS19BP1 Gene Hs.526933

mRNA Expression by UniProt/SwissProt for RPS19BP1 Gene

Tissue specificity: Widely expressed (at protein level).
genes like me logo Genes that share expression patterns with RPS19BP1: view

Protein tissue co-expression partners for RPS19BP1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RPS19BP1 Gene

Orthologs for RPS19BP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RPS19BP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPS19BP1 35
  • 84.07 (n)
  • 76.47 (a)
RPS19BP1 36
  • 77 (a)
(Canis familiaris)
Mammalia RPS19BP1 35
  • 87.25 (n)
  • 80.88 (a)
RPS19BP1 36
  • 80 (a)
(Mus musculus)
Mammalia Rps19bp1 35
  • 81.37 (n)
  • 78.68 (a)
Rps19bp1 16
Rps19bp1 36
  • 74 (a)
(Pan troglodytes)
Mammalia RPS19BP1 35
  • 99.75 (n)
  • 100 (a)
RPS19BP1 36
  • 100 (a)
(Monodelphis domestica)
Mammalia RPS19BP1 36
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia RPS19BP1 36
  • 39 (a)
(Gallus gallus)
Aves RPS19BP1 35
  • 58.4 (n)
  • 52.63 (a)
RPS19BP1 36
  • 46 (a)
(Anolis carolinensis)
Reptilia RPS19BP1 36
  • 42 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rps19bp1 35
  • 47.65 (n)
  • 39.26 (a)
(Danio rerio)
Actinopterygii rps19bp1 36
  • 35 (a)
Species with no ortholog for RPS19BP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPS19BP1 Gene

Gene Tree for RPS19BP1 (if available)
Gene Tree for RPS19BP1 (if available)

Paralogs for RPS19BP1 Gene

No data available for Paralogs for RPS19BP1 Gene

Variants for RPS19BP1 Gene

Sequence variations from dbSNP and Humsavar for RPS19BP1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs17001278 - 39,529,532(+) AGTCT(G/T)CCTCG nc-transcript-variant, reference, missense
rs14729 -- 39,529,231(+) CAAAA(A/C)AGATA nc-transcript-variant, utr-variant-3-prime
rs2413595 -- 39,534,192(+) TCCTG(C/T)CCCAG upstream-variant-2KB
rs34398019 -- 39,532,393(+) ACTTA(-/C)CCCAG splice-donor-variant
rs77249721 -- 39,534,565(+) GCTCC(A/G/T)CAAGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPS19BP1 Gene

Variant ID Type Subtype PubMed ID
nsv834199 CNV Loss 17160897
nsv915099 CNV Loss 21882294
nsv3629 CNV Insertion 18451855

Variation tolerance for RPS19BP1 Gene

Residual Variation Intolerance Score: 44.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.77% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RPS19BP1 Gene

Disorders for RPS19BP1 Gene

Relevant External Links for RPS19BP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RPS19BP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPS19BP1 Gene

Publications for RPS19BP1 Gene

  1. A novel nucleolar protein interacts with ribosomal protein S19. (PMID: 16289379) Maeda N. … Tanaka T. (Biochem. Biophys. Res. Commun. 2006) 2 3 23 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  4. AROS has a context-dependent effect on SIRT1. (PMID: 24681097) Kokkola T. … Lahtela-Kakkonen M. (FEBS Lett. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for RPS19BP1 Gene

Sources for RPS19BP1 Gene