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Aliases for RPS19BP1 Gene

Aliases for RPS19BP1 Gene

  • Ribosomal Protein S19 Binding Protein 1 2 3 5
  • 40S Ribosomal Protein S19-Binding Protein 1 3 4
  • RPS19-Binding Protein 1 3 4
  • S19BP 3 4
  • AROS 3 4
  • Homolog Of Mouse S19 Binding Protein 3
  • Active Regulator Of SIRT1 3

External Ids for RPS19BP1 Gene

Previous GeneCards Identifiers for RPS19BP1 Gene

  • GC22M038255
  • GC22M039925
  • GC22M022889
  • GC22M039563
  • GC22M039839
  • GC22M039851
  • GC22M039946
  • GC22M040637
  • GC22M041082

Summaries for RPS19BP1 Gene

GeneCards Summary for RPS19BP1 Gene

RPS19BP1 (Ribosomal Protein S19 Binding Protein 1) is a Protein Coding gene. Among its related pathways are Cellular Senescence (REACTOME) and Cellular response to heat stress. GO annotations related to this gene include poly(A) RNA binding and enzyme binding.

UniProtKB/Swiss-Prot for RPS19BP1 Gene

  • Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity.

Additional gene information for RPS19BP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS19BP1 Gene

Genomics for RPS19BP1 Gene

Regulatory Elements for RPS19BP1 Gene

Enhancers for RPS19BP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H039462 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +63.6 63582 14 HDGF PKNOX1 MLX ARID4B DMAP1 YY1 ZNF143 SP5 REST ZNF592 MGAT3 SYNGR1 ENSG00000230912 MIEF1 RPS19BP1 TAB1 MGAT3-AS1 DDX17
GH22H039500 1.3 ENCODE dbSUPER 12 +30.4 30420 3 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 SP3 ATF4 MGAT3 RPS19BP1 MGAT3-AS1 LOC105373035 GC22P039509 GC22P039507 GC22P039504
GH22H039518 2 FANTOM5 Ensembl ENCODE dbSUPER 5 +8.5 8472 12 MLX DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC ZFP41 SSRP1 ENSG00000272834 TAB1 ENSG00000230912 ATF4 ENSG00000228274 RPL3 CBY1 CBX6 SNORD83B CBX7
GH22H039530 1.3 ENCODE dbSUPER 5.4 +0.7 725 2 HDGF FOXA2 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF416 ZNF143 ATF4 RPL3 TNRC6B ENSG00000228274 RPS19BP1 GC22P039523 PIR62526
GH22H039905 1.4 Ensembl ENCODE dbSUPER 4.8 -376.1 -376139 6 TBP HDGF PKNOX1 FOXA2 BMI1 YBX1 BATF POLR3A ATF7 ETV6 CACNA1I RPS19BP1 ENTHD1 ENSG00000225528
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPS19BP1 on UCSC Golden Path with GeneCards custom track

Promoters for RPS19BP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000146360 155 1400 HDGF FOXA2 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF416 ZNF143

Genomic Location for RPS19BP1 Gene

Chromosome:
22
Start:
39,529,093 bp from pter
End:
39,532,855 bp from pter
Size:
3,763 bases
Orientation:
Minus strand

Genomic View for RPS19BP1 Gene

Genes around RPS19BP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS19BP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS19BP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS19BP1 Gene

Proteins for RPS19BP1 Gene

  • Protein details for RPS19BP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WX3-AROS_HUMAN
    Recommended name:
    Active regulator of SIRT1
    Protein Accession:
    Q86WX3
    Secondary Accessions:
    • B0QY96
    • Q5JZA1

    Protein attributes for RPS19BP1 Gene

    Size:
    136 amino acids
    Molecular mass:
    15434 Da
    Quaternary structure:
    • Interacts with RPS19 (By similarity). Interacts with SIRT1.

neXtProt entry for RPS19BP1 Gene

Post-translational modifications for RPS19BP1 Gene

Other Protein References for RPS19BP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPS19BP1 Gene

Domains & Families for RPS19BP1 Gene

Gene Families for RPS19BP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RPS19BP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RPS19BP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86WX3

UniProtKB/Swiss-Prot:

AROS_HUMAN :
  • Belongs to the AROS family.
Family:
  • Belongs to the AROS family.
genes like me logo Genes that share domains with RPS19BP1: view

Function for RPS19BP1 Gene

Molecular function for RPS19BP1 Gene

UniProtKB/Swiss-Prot Function:
Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity.

Phenotypes From GWAS Catalog for RPS19BP1 Gene

Gene Ontology (GO) - Molecular Function for RPS19BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI 17964266
GO:0019899 enzyme binding IPI 23382074
genes like me logo Genes that share ontologies with RPS19BP1: view
genes like me logo Genes that share phenotypes with RPS19BP1: view

Animal Models for RPS19BP1 Gene

MGI Knock Outs for RPS19BP1:

Animal Model Products

CRISPR Products

miRNA for RPS19BP1 Gene

miRTarBase miRNAs that target RPS19BP1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RPS19BP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RPS19BP1 Gene

Localization for RPS19BP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS19BP1 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS19BP1 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (4)
  • Cytosol (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPS19BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm ISS 16289379
GO:0005730 nucleolus ISS 16289379
GO:0005829 cytosol IDA --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with RPS19BP1: view

Pathways & Interactions for RPS19BP1 Gene

genes like me logo Genes that share pathways with RPS19BP1: view

Pathways by source for RPS19BP1 Gene

Gene Ontology (GO) - Biological Process for RPS19BP1 Gene

None

No data available for SIGNOR curated interactions for RPS19BP1 Gene

Drugs & Compounds for RPS19BP1 Gene

No Compound Related Data Available

Transcripts for RPS19BP1 Gene

Unigene Clusters for RPS19BP1 Gene

Ribosomal protein S19 binding protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RPS19BP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RPS19BP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d
SP1: - -
SP2: - - -
SP3: - - -
SP4:
SP5: - - -
SP6:

Relevant External Links for RPS19BP1 Gene

GeneLoc Exon Structure for
RPS19BP1
ECgene alternative splicing isoforms for
RPS19BP1

Expression for RPS19BP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPS19BP1 Gene

Protein differential expression in normal tissues from HIPED for RPS19BP1 Gene

This gene is overexpressed in Lung (28.3) and Breast (25.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPS19BP1 Gene



Protein tissue co-expression partners for RPS19BP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RPS19BP1 Gene:

RPS19BP1

SOURCE GeneReport for Unigene cluster for RPS19BP1 Gene:

Hs.526933

mRNA Expression by UniProt/SwissProt for RPS19BP1 Gene:

Q86WX3-AROS_HUMAN
Tissue specificity: Widely expressed (at protein level).

Evidence on tissue expression from TISSUES for RPS19BP1 Gene

  • Skin(4.2)
  • Nervous system(3.3)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with RPS19BP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS19BP1 Gene

Orthologs for RPS19BP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RPS19BP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPS19BP1 33 34
  • 99.75 (n)
dog
(Canis familiaris)
Mammalia RPS19BP1 33 34
  • 87.25 (n)
cow
(Bos Taurus)
Mammalia RPS19BP1 33 34
  • 84.07 (n)
mouse
(Mus musculus)
Mammalia Rps19bp1 33 16 34
  • 81.37 (n)
oppossum
(Monodelphis domestica)
Mammalia RPS19BP1 34
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPS19BP1 34
  • 39 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPS19BP1 33 34
  • 58.4 (n)
lizard
(Anolis carolinensis)
Reptilia RPS19BP1 34
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rps19bp1 33
  • 47.65 (n)
zebrafish
(Danio rerio)
Actinopterygii rps19bp1 34
  • 35 (a)
OneToOne
Species where no ortholog for RPS19BP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPS19BP1 Gene

ENSEMBL:
Gene Tree for RPS19BP1 (if available)
TreeFam:
Gene Tree for RPS19BP1 (if available)

Paralogs for RPS19BP1 Gene

No data available for Paralogs for RPS19BP1 Gene

Variants for RPS19BP1 Gene

Sequence variations from dbSNP and Humsavar for RPS19BP1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000258840 -- 39,533,220(+) CTCAT(A/T)AAATA upstream-variant-2KB
rs1000596569 -- 39,534,577(+) AGGGA(A/T)CTTTG upstream-variant-2KB
rs1000822683 -- 39,529,237(+) AGATA(C/T)GTTCC nc-transcript-variant, utr-variant-3-prime
rs1000962710 -- 39,530,995(+) CTAGG(C/T)TTCTG intron-variant
rs1001081913 -- 39,530,816(+) GGGGT(C/G)GGGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPS19BP1 Gene

Variant ID Type Subtype PubMed ID
nsv3629 CNV insertion 18451855
nsv834199 CNV loss 17160897

Variation tolerance for RPS19BP1 Gene

Residual Variation Intolerance Score: 44.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS19BP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPS19BP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS19BP1 Gene

Disorders for RPS19BP1 Gene

Relevant External Links for RPS19BP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPS19BP1

No disorders were found for RPS19BP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPS19BP1 Gene

Publications for RPS19BP1 Gene

  1. A novel nucleolar protein interacts with ribosomal protein S19. (PMID: 16289379) Maeda N … Tanaka T (Biochemical and biophysical research communications 2006) 2 3 22 60
  2. Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity. (PMID: 17964266) Kim EJ … Um SJ (Molecular cell 2007) 3 4 60
  3. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 3 4 60

Products for RPS19BP1 Gene

Sources for RPS19BP1 Gene

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