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Aliases for RPS19BP1 Gene

Aliases for RPS19BP1 Gene

  • Ribosomal Protein S19 Binding Protein 1 2 3
  • S19BP 3 4 6
  • 40S Ribosomal Protein S19-Binding Protein 1 3 4
  • RPS19-Binding Protein 1 3 4
  • AROS 3 4
  • Homolog Of Mouse S19 Binding Protein 3
  • Active Regulator Of SIRT1 3
  • MGC52010 6

External Ids for RPS19BP1 Gene

Previous GeneCards Identifiers for RPS19BP1 Gene

  • GC22M038255
  • GC22M039925
  • GC22M022889

Summaries for RPS19BP1 Gene

GeneCards Summary for RPS19BP1 Gene

RPS19BP1 (Ribosomal Protein S19 Binding Protein 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for RPS19BP1 Gene

  • Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS19BP1 Gene

Genomics for RPS19BP1 Gene

Regulatory Elements for RPS19BP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RPS19BP1 Gene

Start:
39,529,093 bp from pter
End:
39,532,855 bp from pter
Size:
3,763 bases
Orientation:
Minus strand

Genomic View for RPS19BP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPS19BP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS19BP1 Gene

Proteins for RPS19BP1 Gene

  • Protein details for RPS19BP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WX3-AROS_HUMAN
    Recommended name:
    Active regulator of SIRT1
    Protein Accession:
    Q86WX3
    Secondary Accessions:
    • B0QY96
    • Q5JZA1

    Protein attributes for RPS19BP1 Gene

    Size:
    136 amino acids
    Molecular mass:
    15434 Da
    Quaternary structure:
    • Interacts with RPS19 (By similarity). Interacts with SIRT1.

neXtProt entry for RPS19BP1 Gene

Proteomics data for RPS19BP1 Gene at MOPED

Post-translational modifications for RPS19BP1 Gene

Other Protein References for RPS19BP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RPS19BP1 Gene

Domains for RPS19BP1 Gene

Protein Domains for RPS19BP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RPS19BP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86WX3

UniProtKB/Swiss-Prot:

AROS_HUMAN :
  • Q86WX3
Family:
  • Belongs to the AROS family.
genes like me logo Genes that share domains with RPS19BP1: view

No data available for Gene Families for RPS19BP1 Gene

Function for RPS19BP1 Gene

Molecular function for RPS19BP1 Gene

UniProtKB/Swiss-Prot Function: Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity.

Gene Ontology (GO) - Molecular Function for RPS19BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17964266
GO:0019899 enzyme binding IPI 23382074
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPS19BP1: view

Phenotypes for RPS19BP1 Gene

GenomeRNAi human phenotypes for RPS19BP1:
genes like me logo Genes that share phenotypes with RPS19BP1: view

Animal Model Products

CRISPR Products

miRNA for RPS19BP1 Gene

miRTarBase miRNAs that target RPS19BP1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPS19BP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPS19BP1 Gene

Localization for RPS19BP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS19BP1 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS19BP1 Gene COMPARTMENTS Subcellular localization image for RPS19BP1 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for RPS19BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm ISS 16289379
GO:0005730 nucleolus ISS 16289379
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with RPS19BP1: view

Pathways for RPS19BP1 Gene

SuperPathways for RPS19BP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RPS19BP1 Gene

None

No data available for Pathways by source for RPS19BP1 Gene

Transcripts for RPS19BP1 Gene

mRNA/cDNA for RPS19BP1 Gene

Unigene Clusters for RPS19BP1 Gene

Ribosomal protein S19 binding protein 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPS19BP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS19BP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d
SP1: - -
SP2: - - -
SP3: - - -
SP4:
SP5: - - -
SP6:

Relevant External Links for RPS19BP1 Gene

GeneLoc Exon Structure for
RPS19BP1
ECgene alternative splicing isoforms for
RPS19BP1

Expression for RPS19BP1 Gene

mRNA expression in normal human tissues for RPS19BP1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS19BP1 Gene

SOURCE GeneReport for Unigene cluster for RPS19BP1 Gene Hs.526933

mRNA Expression by UniProt/SwissProt for RPS19BP1 Gene

Q86WX3-AROS_HUMAN
Tissue specificity: Widely expressed (at protein level).
genes like me logo Genes that share expressions with RPS19BP1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RPS19BP1 Gene

Orthologs for RPS19BP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RPS19BP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPS19BP1 35
  • 99.75 (n)
  • 100 (a)
RPS19BP1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RPS19BP1 35
  • 84.07 (n)
  • 76.47 (a)
RPS19BP1 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPS19BP1 35
  • 87.25 (n)
  • 80.88 (a)
RPS19BP1 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rps19bp1 35
  • 81.37 (n)
  • 78.68 (a)
Rps19bp1 16
Rps19bp1 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RPS19BP1 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPS19BP1 36
  • 39 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPS19BP1 35
  • 58.4 (n)
  • 52.63 (a)
RPS19BP1 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPS19BP1 36
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rps19bp1 35
  • 47.65 (n)
  • 39.26 (a)
zebrafish
(Danio rerio)
Actinopterygii rps19bp1 36
  • 35 (a)
OneToOne
Species with no ortholog for RPS19BP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPS19BP1 Gene

ENSEMBL:
Gene Tree for RPS19BP1 (if available)
TreeFam:
Gene Tree for RPS19BP1 (if available)

Paralogs for RPS19BP1 Gene

No data available for Paralogs for RPS19BP1 Gene

Variants for RPS19BP1 Gene

Sequence variations from dbSNP and Humsavar for RPS19BP1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs14729 -- 39,529,231(+) CAAAA(A/C)AGATA utr-variant-3-prime
rs1015940 -- 39,530,756(+) caaca(A/C)caaaa intron-variant
rs1015941 -- 39,530,957(+) attac(A/G)ggggg intron-variant
rs1028320 -- 39,530,856(+) agacc(A/G)ccacc intron-variant
rs1028321 -- 39,530,924(+) tacac(A/G)atcac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPS19BP1 Gene

Variant ID Type Subtype PubMed ID
nsv834199 CNV Loss 17160897
nsv915099 CNV Loss 21882294
nsv3629 CNV Insertion 18451855

Relevant External Links for RPS19BP1 Gene

HapMap Linkage Disequilibrium report
RPS19BP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS19BP1 Gene

Disorders for RPS19BP1 Gene

No disorders were found for RPS19BP1 Gene.

No data available for UniProtKB/Swiss-Prot for RPS19BP1 Gene

Publications for RPS19BP1 Gene

  1. A novel nucleolar protein interacts with ribosomal protein S19. (PMID: 16289379) Maeda N. … Tanaka T. (Biochem. Biophys. Res. Commun. 2006) 2 3 23
  2. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  3. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity. (PMID: 17964266) Kim E.-J. … Um S.-J. (Mol. Cell 2007) 3 4

Products for RPS19BP1 Gene

  • antibodies-online proteins for RPS19BP1
  • antibodies-online antibodies for RPS19BP1
  • antibodies-online kits for RPS19BP1

Sources for RPS19BP1 Gene

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