RPS19BP1 Gene
protein-coding GIFtS: 46
GCID: GC22M039925
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|
ribosomal protein S19 binding protein 1
| |
Aliases
for RPS19BP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ribosomal Protein S19 Binding Protein 11 2 | | MGC520101 5 | | S19BP2 3 5 | | FLJ217701 | | 40S Ribosomal Protein S19-Binding Protein 12 3 | | Active Regulator Of SIRT12 | | AROS2 3 | | DJ1104E15.41 | | RPS19-Binding Protein 12 3 | | Homolog Of Mouse S19 Binding Protein2 |
Export aliases for RPS19BP1 gene to outside databasesPrevious GC identifers: GC22M038255 GC22M022889 |
Summaries
for RPS19BP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: AROS_HUMAN, Q86WX3Function: Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating ininhibition of p53/TP53-mediated transcriptional activity
|
Genomic Views
for RPS19BP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RPS19BP1 gene promoter:
HOXA9B HOXA9 Meis-1b FOXJ2 (long isoform) ZIC2/Zic2 Meis-1a FOXJ2 Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for RPS19BP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS19BP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q13.1 Ensembl cytogenetic band: 22q13.1 HGNC cytogenetic band: 22q13.1RPS19BP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22M039925: view genomic region
(about GC identifiers)
Start:
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39,925,098 bp from pter |
End:
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39,928,860 bp from pter |
Size:
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3,763 bases |
Orientation:
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minus strand |
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Proteins
for RPS19BP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AROS_HUMAN, Q86WX3 (See
protein sequence)Recommended Name: Active regulator of SIRT1 Size: 136 amino acids; 15434 Da
Subunit: Interacts with RPS19 (By similarity). Interacts with SIRT1
Subcellular location: Nucleus, nucleolus
Secondary accessions: B0QY96 Q5JZA1Explore the universe of human proteins at neXtProt for RPS19BP1: NX_Q86WX3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86WX3
RPS19BP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_919307.1
ENSEMBL proteins: ENSP00000333948 ENSP00000399304
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
RPS19BP1 for ontologies About GeneDecksing
RPS19BP1 Antibody Products:
Assay Products for RPS19BP1: |
Protein
Domains /
Families
for RPS19BP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RPS19BP1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q86WX3ProtoNet protein and cluster: Q86WX3 UniProtKB/Swiss-Prot: AROS_HUMAN, Q86WX3Similarity: Belongs to the AROS family |
Function
for RPS19BP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: AROS_HUMAN, Q86WX3Function: Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating ininhibition of p53/TP53-mediated transcriptional activity
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPS19BP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPS19BP1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RPS19BP1 (NM_194326) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPS19BP1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS19BP1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
RPS19BP1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for RPS19BP1:
|
Pathways & Interactions
for RPS19BP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPS19BP1
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for RPS19BP1 (Q86WX31, 3 ENSP000003339484) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for RPS19BP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RPS19BP1
Search CenterWatch for drugs/clinical trials and news about RPS19BP1 / AROS
|
Transcripts
for RPS19BP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RPS19BP1 gene: NM_194326.2 Unigene Cluster for RPS19BP1: Ribosomal protein S19 binding protein 1 Hs.526933 [show with all ESTs]Unigene Representative Sequence: BM9069206 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000334678(uc003ayb.3) ENST00000488602 ENST00000420879 ENST00000459956
ENST00000491966 ENST00000472291
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPS19BP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPS19BP1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RPS19BP1 (NM_194326) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPS19BP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS19BP1 |
Additional cDNA sequence: AK025423.1 BC037573.1 BC047711.1 CR456443.1 7 DOTS entries: DT.120691 DT.100810397 DT.95107790 DT.75183215 DT.100657566 DT.95107814 DT.97847896 24/259 AceView cDNA sequences (see all 259): BU584972 AI298756 BM782041 BQ949561 BG716279 BG014741 AW044234 BU623537 CA306952 CR613278 BU738025 BM763751 BM918069 BG397654 CD671203 BM806269 AW964799 BF196607 BE264258 BU580369 BQ687237 BQ576158 BM765071 BE274335
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RPS19BP1 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d |
|---|
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| SP1: | | | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for RPS19BP1
|
Expression
for RPS19BP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RPS19BP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCGCCGCCC
About this image
See RPS19BP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RPS19BP1
SOURCE GeneReport for Unigene cluster: Hs.526933
UniProtKB/Swiss-Prot: AROS_HUMAN, Q86WX3Tissue specificity: Widely expressed (at protein level)
SABiosciences Custom PCR Arrays for RPS19BP1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPS19BP1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RPS19BP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS19BP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS19BP1 |
Orthologs
for RPS19BP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for RPS19BP1 gene from 3/9 species (see all 9) About this table
ENSEMBL Gene Tree for RPS19BP1 (if available)
TreeFam Gene Tree for RPS19BP1 (if available) |
Paralogs
for RPS19BP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for RPS19BP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RPS19BP1 (39925098 - 39928860 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RPS19BP1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPS19BP1 |
|
Disorders
/ Diseases
for RPS19BP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RPS19BP1 for disorders About GeneDecksing
OMIM gene information: 610225
OMIM disorders: --
2  diseases for RPS19BP1: About MalaCardssevere acute respiratory syndrome gastroenteritis
Export disorders for RPS19BP1 gene to outside databases
|
Publications
for RPS19BP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RPS19BP1 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with RPS19BP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel nucleolar protein interacts with ribosomal protein S19. (PubMed id 16289379)1, 3, 9 Maeda N....Tanaka T. (2006)
- Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity. (PubMed id 17964266)1, 2 Kim E.J....Um S.J. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
|
External Searches for RPS19BP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RPS19BP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RPS19BP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RPS19BP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RPS19BP1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for RPS19BP1 gene:
Search GeneIP for patents involving RPS19BP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RPS19BP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RPS19BP1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPS19BP1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPS19BP1 | | | OriGene Protein Over-expression Lysate for RPS19BP1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RPS19BP1 | | OriGene 3'-UTR Clone for RPS19BP1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPS19BP1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPS19BP1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RPS19BP1 | | OriGene Custom Protein Services for RPS19BP1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RPS19BP1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPS19BP1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS19BP1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS19BP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS19BP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS19BP1 |
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 | | | RPS19BP1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS19BP1 |
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