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RPS19 Gene

protein-coding GIFtS: 69

GC19P047055

ribosomal protein S19
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DBA ^¹, ², ⁵

Descriptions
40S ribosomal protein S19 ^²
ribosomal protein S19 ^²

External Ids
HGNC: 10402¹
Entrez Gene: 6223²
UniProtKB: P39019³
Ensembl: ENSG00000105372⁷

Search outside databases for aliases for RPS19 gene

Previous GC identifers: GC19P043003 GC19P042755 GC19P047040

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for RPS19:

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a

large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80

structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the

40S subunit. The protein belongs to the S19E family of ribosomal proteins. It is located in the

cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia (DBA), a constitutional

erythroblastopenia characterized by absent or decreased erythroid precursors, in a subset of

patients. This suggests a possible extra-ribosomal function for this gene in erythropoietic

differentiation and proliferation, in addition to its ribosomal function. Higher expression levels

of this gene in some primary colon carcinomas compared to matched normal colon tissues has been

observed. As is typical for genes encoding ribosomal proteins, there are multiple processed

pseudogenes of this gene dispersed through the genome. [provided by RefSeq]

UniProtKB/Swiss-Prot: RS19_HUMAN, P39019

Function: Required for pre-rRNA processing and maturation of 40S ribosomal subunits

Gene Wiki entry for RPS19 (Ribosomal_protein_S19)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the RPS19 gene

Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.2

RPS19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P047055: (about GC identifiers)

Start:	47,055,828 bp from pter
End:	47,067,324 bp from pter
Size:	11,497 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000019.8 NT_011109.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: RS19_HUMAN, P39019 (See protein sequence)

Recommended Name: 40S ribosomal protein S19

Size: 145 amino acids; 16060 Da

Subunit: Interacts with RPS19BP1 (By similarity)

Subcellular location: Nucleus. Note=Located more specifically in the nucleoli

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001013.1

ENSEMBL proteins:

ENSP00000221975

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (RPS19)
	Human Recombinant Proteins from Abnova (RPS19)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IEA	--
GO:0005730	nucleolus	IDA	16289379
GO:0005829	cytosol	EXP	12588972
GO:0005840	ribosome	IEA	--

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Antibodies for RPS19:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for RPS19
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (RPS19), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (RPS19)
	Novus Biologicals Antibodies for RPS19

Assays for RPS19:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P39019

ProtoNet protein and cluster: P39019

1 Blocks protein family: IPB001266 Ribosomal protein S19e

UniProtKB/Swiss-Prot: RS19_HUMAN, P39019

Similarity: Belongs to the ribosomal protein S19e family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RPS19)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RPS19)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001022

Applied Biosystems Silencer® siRNAs for RPS19

Sigma-Aldrich siRNA for RPS19

Sigma-Aldrich shRNA for RPS19

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for RPS19
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001022
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001022
untagged cDNA clone in CMV expression vector: NM_001022

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001022

UniProtKB/Swiss-Prot: RS19_HUMAN, P39019

Function: Required for pre-rRNA processing and maturation of 40S ribosomal subunits

Genatlas biochemistry entry for RPS19:

40S ribosomal protein S19

5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Rps19):

hematopoietic system

lethality-prenatal/perinatal

limbs/digits/tail

pigmentation

skin/coat/nails

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003723	RNA binding	TAS	9988267
GO:0003735	structural constituent of ribosome	IDA	15883184
GO:0005515	protein binding	IPI	17353931

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for RPS19

5/121 Interacting proteins for RPS19 (P39019^{1, 2} ENSP00000221975³) via UniProtKB, MINT, and/or STRING (see all 121 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CNBP	P62633¹	EBI-354451, EBI-1047529
MAGEB2	O15479¹	EBI-354451, EBI-1057615
PINX1	Q96BK5¹	EBI-354451, EBI-721782
FGF2	P09038²	MINT-14337
NFKB2	Q00653²	MINT-48752

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5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006364	rRNA processing	IMP	18697920
GO:0006414	translational elongation	EXP	15189156
GO:0009991	response to extracellular stimulus	TAS	16289379
GO:0015669	gas transport	IMP	9988267
GO:0030218	erythrocyte differentiation	IMP	16289379

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for RPS19
1 Novoseek chemical compound relationship for RPS19 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
rrna	36.42	8	17376718 (2), 18697920 (1), 17053056 (1), 8188044 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RPS19)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RPS19)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001022

Sigma-Aldrich siRNA for RPS19

Sigma-Aldrich shRNA for RPS19

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001022

REFSEQ mRNAs for RPS19 gene:

NM_001022.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001022

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001022
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001022
                                 untagged cDNA clone in CMV expression vector: NM_001022

Additional cDNA sequence:

AK311786.1 BC000023.2 BC007615.2 BC017386.1 BC018616.1 M81757.1

24/66 DOTS entries (see all 66 ):

DT.95150873 DT.451466 DT.100701260 DT.100701255 DT.91781136 DT.100651397 DT.422781 DT.121486065

DT.92057542 DT.121486123 DT.97863855 DT.121486080 DT.95120271 DT.121486048 DT.121486075 DT.101987507

DT.100057430 DT.100701243 DT.100701246 DT.97846754 DT.100850034 DT.120820 DT.121486129 DT.75173202

24/2533 AceView cDNA sequences (see all 2533 ):

BQ070067 BF001194 BM889510 AA328492 AI735508 BU785798 BG746669 AW161113

BI769684 AA368860 BI857673 BM766244 W72287 F32037 AI748831 BI115678

AI129764 AI310009 BI834740 AA327060 BQ058545 AI151150 CB111170 BG033557

highest scoring ESTs for RPS19:

M81757 AA045577 AA046009 AA053243 AA057843 AA081154 AA083518 AA085334 AA085896 AA143236

Unigene Cluster for RPS19:

Ribosomal protein S19

Hs.438429 [show with all ESTs]

Unigene Representative Sequence: BQ066037

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for RPS19 (see all 8 )

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2a	·	2b	^	3a	·	3b	·	3c	^	4	^	5	^	6	^	7	^	8
SP1:							-		-								-		-		-		-
SP2:							-		-										-		-		-
SP3:							-		-		-						-		-		-		-
SP4:									-								-		-		-		-
SP5:																	-		-		-		-

About this scheme

ECgene alternative splicing isoforms for RPS19

1 Ensembl transcript including schematic representation:

ENST00000221975

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

RPS19 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for RPS19

¹ / ² / ³

6 probe-sets matching RPS19 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
31330_at²^{, 3}	U95-A	7	1.00	0.42	0.97	0.98	M81757	1.00	1.00	1.00	1
79903_f_at²^{, 3}	U95-E	6	0.94	0.33	0.98	1.02	AI985514	0.80	0.67	0.74	1
202649_x_at²^{, 3}	U133-A	6	1.00	0.41	--	--	NM_001022	0.60	1.00	0.82	1
213414_s_at²^{, 3}	U133-A	7	1.00	0.38	--	--	BE259729	0.40	1.00	0.76	1
202649_x_at²	U133Plus2	6	1.00	0.41	--	--	--	--	--	--	--
213414_s_at²	U133Plus2	7	1.00	0.38	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTGGGTTAAT

SOURCE GeneReport for Unigene cluster: Hs.438429
Expression variation in blood from EXPOLDB for RPS19
UniProtKB/Swiss-Prot: RS19_HUMAN, P39019
Tissue specificity: Higher level expression is seen in the colon carcinoma tissue than normal colon
tissue

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for RPS19 gene from 5/20 species (see all 20 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	RPS19¹	--	ribosomal protein S19	95.63(n) 100(a)	476450 XM_533657.2 XP_533657.2
chimpanzee (Pan troglodytes)	RPS19¹	--	ribosomal protein S19	98.84(n) 99.31(a)	456065 XM_512692.2 XP_512692.2
cow (Bos taurus)	RPS19¹	--	ribosomal protein S19	95.63(n) 100(a)	516063 NM_001037467.1 NP_001032544.1
rat (Rattus norvegicus)	Rps19¹	--	ribosomal protein S19	93.56(n) 99.31(a)	29287 NM_001037346.1 NP_001032423.1
mouse (Mus musculus)	Rps19^{1, 5}	7 (6.00 cM)⁵	ribosomal protein S19^{1, 5}	93.33(n)¹ 99.31(a)¹	20085¹ NM_023133.1¹ NP_075622.1¹ AF216207⁵ AK012052⁵ (see all 15)

About this table Species with no ortholog for RPS19

ENSEMBL Gene Tree for RPS19

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/132 NCBI SNPs in RPS19 are shown (see all 132 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 35)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs8101003^1,2	H	47067602(+)	`CAGTCG/AGGCCT`	1	--	ng3¹		4	EU EA WA	410
	rs2075751^1,2	A,C,F,H,O	47065733(+)	`TACTTT/CGTCAG`	1	--	int¹		12	EA EU WA NA	2478
--	rs1366610^1,2	A,C,F,H,O	47065138(+)	`GGTAGA/GGGGGG`	1	--	int¹		10	EA NA MN EU WA	2236
	rs3786536^1,2	A,C,F,H	47064297(-)	`ACCCTT/GCTTCA`	1	--	int¹		8	EA EU NA	2154
	rs2075752^1,2	A,C,F,H	47066676(+)	`TTGGCG/TCACAC`	1	--	int¹		9	EA EU WA	2140
	rs3786539^1,2	A,C,F,H	47058072(-)	`AGGAGT/CTTTGC`	1	--	int¹		8	EU EA WA	834
	rs2075754^1,2	A,C,F,H	47067084(+)	`gagacT/Ccagtt`	1	--	int¹		4	EU EA WA	388
	rs7254214^1,2	C,F,H	47060578(+)	`AGGTAG/AGGGGT`	1	--	int¹		4	EU EA WA	420
	rs12974044^1,2	C,F,H	47060469(+)	`TGCTCA/GGATCC`	1	--	int¹		4	EU EA WA	420
	rs930102^1,2	A,C,F	47056235(+)	`CGAGGT/CGGCAG`	1	--	int¹		1	MN	184

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HapMap Linkage Disequilibrium images for RPS19 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603474 disorders: 105650

UniProtKB/Swiss-Prot: RS19_HUMAN, P39019

Defects in RPS19 are the cause of Diamond-Blackfan anemia type 1 (DBA1) [MIM:105650]. DBA1

is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that

usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to

severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of

Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most

frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital

anomalies

10/17 Novoseek disease relationships for RPS19 gene (see all 17 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
diamond-blackfan anemia	98.24	69	18768533 (4), 17178250 (3), 16159874 (2), 12586610 (2) (see all 35)
anemia hypoplastic congenital	93.51	4	12586610 (1), 17517689 (1), 15523650 (1)
congenital pure red cell aplasia	88.07	2	16531079 (1)
anemia macrocytic	81.02	2	16531079 (1)
anemia hypoplastic	78.57	1	16159874 (1)
aplasia	72.57	1	17186470 (1)
anemia	54.71	11	9241274 (2), 18217898 (1), 18386371 (1), 15384984 (1) (see all 9)
anemia severe	43.92	2	16531079 (1), 16088923 (1)
anemia aplastic	33.28	1	16794503 (1)
congenital malformation	16.36	1	18515656 (1)

About this table

Human Gene Mutation Database: RPS19
Human Genome Epidemiology Navigator: RPS19 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/112 PubMed articles for RPS19 gene (see all 112 ):

A map of 75 human ribosomal protein genes. (PubMed id 9582194)^{2, 3, 4} Kenmochi N....Page D.C. (1998)
Nucleolar localization of RPS19 protein in normal cells and mislocalization due to mutations in the nucleolar localization signals in 2 Diamond-Blackfan anemia patients: potential insights into pathophysiology. (PubMed id 12586610)^{1, 3, 4} Da Costa L.... Mohandas N. (2003)
Missense mutations associated with Diamond-Blackfan anemia affect the assembly of ribosomal protein S19 into the ribosome. (PubMed id 17517689)^{1, 3, 4} Angelini M....Loreni F. (2007)
Human RPS19, the gene mutated in Diamond-Blackfan anemia, encodes a ribosomal protein required for the maturation of 40S ribosomal subunits. (PubMed id 16990592)^{1, 3, 4} Flygare J....Ellis S.R. (2007)
Ten novel Diamond-Blackfan anemia mutations and three polymorphisms within the rps19 gene. (PubMed id 12750732)^{1, 3, 4} Proust A.... Delaunay J. (2003)
Mutations in ribosomal protein S19 gene and diamond blackfan anemia: wide variations in phenotypic expression. (PubMed id 10590074)^{1, 3, 4} Willig T.-N.D.... Tchernia G. (1999)
The gene encoding ribosomal protein S19 is mutated in Diamond- Blackfan anaemia. (PubMed id 9988267)^{1, 3, 4} Draptchinskaia N.... Dahl N. (1999)
Molecular basis of Diamond-Blackfan anemia: new findings from the Italian registry and a review of the literature. (PubMed id 15075082)^{1, 3, 4} Campagnoli M.F....Dianzan I. (2004)
RPS19 mutations in patients with Diamond-Blackfan anemia. (PubMed id 18412286)^{1, 3, 4} Campagnoli M.F....Dianzani I. (2008)
Differential expression of S19 ribosomal protein, laminin-binding protein, and human lymphocyte antigen class I messenger RNAs associated with colon carcinoma progression and differentiation. (PubMed id 1339304)^{1, 3, 4} Kondoh N.... Papas T.S. (1992)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6223	HGNC: 10402	AceView: RPS19	Ensembl:ENSG00000105372	euGenes: HUgn6223
ECgene: RPS19	H-InvDB: RPS19

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for RPS19	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.genetests.org/query?gene=RPS19
Diamond-Blackfan Anemia mutation database	http://www.dbagenes.unito.it/home.php?select_db=RPS19

Licensable Technologies for RPS19
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for RPS19:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for RPS19-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for RPS19		Antibodies for RPS19
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for RPS19		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Antibodies for RPS19

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RPS19 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for RPS19

Summaries
for RPS19

Genomic Location
for RPS19

Proteins
for RPS19

Protein Domains/
Families
for RPS19

Gene Function
for RPS19

Pathways & Interactions
for RPS19

Drugs & Compounds
for RPS19

Transcripts
for RPS19

Expression
for RPS19

Orthologs
for RPS19

Paralogs
for RPS19

SNPs/Variants
for RPS19

Disorders & Mutations
for RPS19

Medical News
for RPS19

Publications
for RPS19

Search for RPS19

Genome Databases showing RPS19

Other Databases showing RPS19

Specialized Databases showing RPS19

Licensable Technologies
for RPS19

Services
for RPS19

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

RPS19 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor RPS19

Summariesfor RPS19

Genomic Locationfor RPS19

Proteinsfor RPS19

Protein Domains/Familiesfor RPS19

Gene Functionfor RPS19

Pathways & Interactionsfor RPS19

Drugs & Compoundsfor RPS19

Transcriptsfor RPS19

Expression for RPS19

Orthologsfor RPS19

Paralogsfor RPS19

SNPs/Variantsfor RPS19

Disorders & Mutationsfor RPS19

Medical Newsfor RPS19

Publicationsfor RPS19

Search for RPS19

Genome Databases showing RPS19

Other Databases showing RPS19

Specialized Databases showing RPS19

Licensable Technologiesfor RPS19

Servicesfor RPS19

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for RPS19

Summaries
for RPS19

Genomic Location
for RPS19

Proteins
for RPS19

Protein Domains/
Families
for RPS19

Gene Function
for RPS19

Pathways & Interactions
for RPS19

Drugs & Compounds
for RPS19

Transcripts
for RPS19

Expression
for RPS19

Orthologs
for RPS19

Paralogs
for RPS19

SNPs/Variants
for RPS19

Disorders & Mutations
for RPS19

Medical News
for RPS19

Publications
for RPS19

Licensable Technologies
for RPS19

Services
for RPS19