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Aliases for RPS18 Gene

Aliases for RPS18 Gene

  • Ribosomal Protein S18 2 3
  • D6S218E 3 4
  • KE-3 3 4
  • KE3 3 4
  • Rhabdomyosarcoma Antigen MU-RMS-40.21 3
  • 40S Ribosomal Protein S18 3
  • HKE3 3
  • S18 3

External Ids for RPS18 Gene

Previous Symbols for RPS18 Gene

  • D6S218E

Summaries for RPS18 Gene

Entrez Gene Summary for RPS18 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S13P family of ribosomal proteins. It is located in the cytoplasm. The gene product of the E. coli ortholog (ribosomal protein S13) is involved in the binding of fMet-tRNA, and thus, in the initiation of translation. This gene is an ortholog of mouse Ke3. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS18 Gene

RPS18 (Ribosomal Protein S18) is a Protein Coding gene. Diseases associated with RPS18 include bowen-conradi syndrome. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include structural constituent of ribosome and rRNA binding.

UniProtKB/Swiss-Prot for RPS18 Gene

  • Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.

Gene Wiki entry for RPS18 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS18 Gene

Genomics for RPS18 Gene

Genomic Location for RPS18 Gene

33,272,010 bp from pter
33,276,510 bp from pter
4,501 bases
Plus strand

Genomic View for RPS18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPS18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Regulatory Elements for RPS18 Gene

Proteins for RPS18 Gene

  • Protein details for RPS18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    40S ribosomal protein S18
    Protein Accession:
    Secondary Accessions:
    • P25232
    • Q5SUJ3
    • Q6IPF8

    Protein attributes for RPS18 Gene

    152 amino acids
    Molecular mass:
    17719 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS18 Gene

neXtProt entry for RPS18 Gene

Proteomics data for RPS18 Gene at MOPED

Post-translational modifications for RPS18 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys8, Lys78, Lys94, and Lys106

Other Protein References for RPS18 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RPS18 Gene

Domains for RPS18 Gene

Gene Families for RPS18 Gene

  • RPS :S ribosomal proteins

Protein Domains for RPS18 Gene


  • Belongs to the ribosomal protein S13P family.:
    • P62269
genes like me logo Genes that share domains with RPS18: view

Function for RPS18 Gene

Molecular function for RPS18 Gene

GENATLAS Biochemistry: 40S ribosomal protein S18,17kDa
UniProtKB/Swiss-Prot Function: Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.

Gene Ontology (GO) - Molecular Function for RPS18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding --
GO:0003735 structural constituent of ribosome IBA --
GO:0005515 protein binding IPI 22720776
GO:0019843 rRNA binding IEA --
genes like me logo Genes that share ontologies with RPS18: view
genes like me logo Genes that share phenotypes with RPS18: view

miRNA for RPS18 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPS18 Gene

Localization for RPS18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS18 Gene


Subcellular locations from

Jensen Localization Image for RPS18 Gene COMPARTMENTS Subcellular localization image for RPS18 gene
Compartment Confidence
cytosol 5
chloroplast 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPS18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005581 collagen trimer --
GO:0005622 intracellular --
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RPS18: view

Pathways for RPS18 Gene

SuperPathways for RPS18 Gene

Superpath Contained pathways
1 Influenza Viral RNA Transcription and Replication
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 CFTR translational fidelity (class I mutations)
4 Disease
5 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
genes like me logo Genes that share pathways with RPS18: view

Pathways by source for RPS18 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for RPS18 Gene
1 BioSystems pathway for RPS18 Gene

Gene Ontology (GO) - Biological Process for RPS18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
GO:0006415 translational termination TAS --
genes like me logo Genes that share ontologies with RPS18: view

Transcripts for RPS18 Gene

Unigene Clusters for RPS18 Gene

Ribosomal protein S18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPS18 Gene

No ASD Table

Relevant External Links for RPS18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS18 Gene

mRNA expression in normal human tissues for RPS18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS18 Gene

SOURCE GeneReport for Unigene cluster for RPS18 Gene Hs.448854

genes like me logo Genes that share expressions with RPS18: view

Orthologs for RPS18 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS18 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 37
  • 100 (a)
-- 37
  • 100 (a)
(Bos Taurus)
Mammalia RPS18 36
  • 93.2 (n)
  • 100 (a)
RPS18 37
  • 100 (a)
(Canis familiaris)
Mammalia RPS18 36
  • 93.2 (n)
  • 100 (a)
RPS18 37
  • 100 (a)
(Mus musculus)
Mammalia Gm10260 37
  • 99 (a)
Rps18 36
  • 91.89 (n)
  • 100 (a)
Rps18 16
Rps18 37
  • 100 (a)
Rps18-ps3 37
  • 99 (a)
(Monodelphis domestica)
Mammalia RPS18 37
  • 95 (a)
(Rattus norvegicus)
Mammalia Rps18 36
  • 89.91 (n)
  • 100 (a)
(Anolis carolinensis)
Reptilia RPS18 37
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rps18 36
  • 82.24 (n)
  • 98.03 (a)
(Danio rerio)
Actinopterygii rps18 36
  • 81.58 (n)
  • 98.03 (a)
rps18 37
  • 98 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010375 36
  • 69.76 (n)
  • 77.48 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpS18 36
  • 72.37 (n)
  • 77.63 (a)
RpS18 37
  • 78 (a)
RpS18 38
  • 74 (a)
(Caenorhabditis elegans)
Secernentea rps-18 36
  • 70.61 (n)
  • 76.32 (a)
rps-18 37
  • 75 (a)
rps-18 38
  • 76 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER315C 36
  • 68.78 (n)
  • 73.94 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS18A 37
  • 69 (a)
RPS18B 36
  • 64.55 (n)
  • 71.83 (a)
RPS18B 37
  • 69 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B01562g 36
  • 66.43 (n)
  • 71.83 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PFL 36
  • 70.18 (n)
  • 74.34 (a)
(Oryza sativa)
Liliopsida Os07g0173700 36
  • 68.64 (n)
  • 71.71 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00475 36
  • 70.18 (n)
  • 75.66 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps1802 36
  • 67.54 (n)
  • 73.68 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 72 (a)
Species with no ortholog for RPS18:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS18 Gene

Gene Tree for RPS18 (if available)
Gene Tree for RPS18 (if available)

Paralogs for RPS18 Gene

No data available for Paralogs for RPS18 Gene

Variants for RPS18 Gene

Sequence variations from dbSNP and Humsavar for RPS18 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs458434 -- 33,275,048(-) TCACT(G/T)TATCC intron-variant
rs458679 -- 33,274,715(-) agaga(C/G)acacg intron-variant
rs7771360 -- 33,275,103(+) AGCCC(A/C)ATACC intron-variant
rs7771361 -- 33,275,104(+) GCCCA(A/G)TACCT intron-variant
rs10080929 -- 33,274,074(+) gcaca(C/T)gccca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPS18 Gene

Variant ID Type Subtype PubMed ID
nsv830634 CNV Loss 17160897
nsv5249 CNV Loss 18451855
nsv830635 CNV Loss 17160897

Relevant External Links for RPS18 Gene

HapMap Linkage Disequilibrium report

Disorders for RPS18 Gene

(1) MalaCards Diseases for RPS18 Gene

Search for RPS18 Gene in MalaCards »

(1) University of Copenhagen DISEASES for RPS18 Gene

Relevant External Links for RPS18

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RPS18: view

No data available for UniProtKB/Swiss-Prot for RPS18 Gene

Publications for RPS18 Gene

  1. The human homolog of ribosomal protein S18. (PMID: 8441687) Chassin D. … Koman A. (Nucleic Acids Res. 1993) 2 3 4 23
  2. The S18 ribosomal protein is a putative substrate for Ca2+/calmodulin-activated protein kinase II. (PMID: 12145273) Mishra-Gorur K. … Castellot J.J. (J. Biol. Chem. 2002) 3 23
  3. Ribosomal protein S18 identified as a cofilin-binding protein by using phage display library. (PMID: 15532723) Kusui K. … Suzuki K. (Mol. Cell. Biochem. 2004) 3 23
  4. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4

Products for RPS18 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate RPS18
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for RPS18
    • Block miRNA regulation of RPS18 using miScript Target Protectors

    Sources for RPS18 Gene

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