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RPS18 Gene

protein-coding   GIFtS: 60
GCID: GC06P033240

Ribosomal Protein S18


(Previous symbol: D6S218E)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribosomal Protein S181 2     KE32
D6S218E1 2 3     S182
40S Ribosomal Protein S182     Rhabdomyosarcoma Antigen MU-RMS-40.212
HKE32     Ke-33
KE-32     Ke33

External Ids:    HGNC: 104011   Entrez Gene: 62222   Ensembl: ENSG000002315007   OMIM: 1804735   UniProtKB: P622693   

Export aliases for RPS18 gene to outside databases

Previous GC identifers: GC06P033243 GC06P033236 GC06P033232 GC06P033286 GC06P033347 GC06Pf33317 GC06P032981


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RPS18 Gene:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This
gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S13P family
of ribosomal proteins. It is located in the cytoplasm. The gene product of the E. coli ortholog (ribosomal
protein S13) is involved in the binding of fMet-tRNA, and thus, in the initiation of translation. This gene is an
ortholog of mouse Ke3. As is typical for genes encoding ribosomal proteins, there are multiple processed
pseudogenes of this gene dispersed through the genome. (provided by RefSeq, Jul 2008)

GeneCards Summary for RPS18 Gene:
RPS18 (ribosomal protein S18) is a protein-coding gene. Diseases associated with RPS18 include bowen-conradi syndrome, and pasteurellosis. GO annotations related to this gene include structural constituent of ribosome and rRNA binding.

UniProtKB/Swiss-Prot: RS18_HUMAN, P62269
Function: Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA (By
similarity)

Gene Wiki entry for RPS18 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  NT_113891.3  NT_167245.2  NT_167247.2  NT_167248.2  NT_167249.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPS18 gene promoter:
         ER-alpha   TBP   p53   AP-1   Olf-1   Meis-1b   PPAR-alpha   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPS18 promoter sequence
   Search Chromatin IP Primers for RPS18

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPS18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

RPS18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS18 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P033240:  view genomic region     (about GC identifiers)

Start:
33,239,787 bp from pter      End:
33,244,287 bp from pter
Size:
4,501 bases      Orientation:
plus strand

5 alternative locations:
Chr6+,NT_113891.2 4,683,662-4,688,091      Chr6+,NT_167245 4,521,174-4,525,603      Chr6+,NT_167249 4,720,054-4,720,712     
Chr6+,NT_167248 4,472,088-4,476,520      Chr6+,NT_167247 4,713,622-4,718,055     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RS18_HUMAN, P62269 (See protein sequence)
Recommended Name: 40S ribosomal protein S18  
Size: 152 amino acids; 17719 Da
1 PDB 3D structure from and Proteopedia for RPS18:
3J3A (3D)    
Secondary accessions: P25232 Q5SUJ3 Q6IPF8

Explore the universe of human proteins at neXtProt for RPS18: NX_P62269

Explore proteomics data for RPS18 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys8, Lys78, Lys94, Lys106
  • Modification sites at PhosphoSitePlus

  • See RPS18 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_072045.1  
    ENSEMBL proteins: 
     ENSP00000393241   ENSP00000434837  
    Reactome Protein details: P62269

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RPS: S ribosomal proteins

    4 InterPro protein domains:
     IPR027437 30s_Rbsml_prot_S13_C
     IPR010979 Ribosomal_S13-like_H2TH
     IPR001892 Ribosomal_S13
     IPR018269 Ribosomal_S13_CS

    Graphical View of Domain Structure for InterPro Entry P62269

    ProtoNet protein and cluster: P62269

    UniProtKB/Swiss-Prot: RS18_HUMAN, P62269
    Similarity: Belongs to the ribosomal protein S13P family


    RPS18 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RS18_HUMAN, P62269
    Function: Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA (By
    similarity)

         Genatlas biochemistry entry for RPS18:
    40S ribosomal protein S18,17kDa

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0003735structural constituent of ribosome IBA--
    GO:0019843rRNA binding IEA--
         
    RPS18 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for RPS18:
     Decreased Hepatitis C virus re  Increased S DNA content  Increased number of cells in m 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Rps18):
     normal 

    RPS18 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RPS18
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RPS18

    miRNA
    Products:
        
    miRTarBase miRNAs that target RPS18:
    hsa-mir-421 (MIRT039415), hsa-mir-27a-3p (MIRT050014), hsa-mir-484 (MIRT041672), hsa-mir-193b-3p (MIRT041265)

    Block miRNA regulation of human, mouse, rat RPS18 using miScript Target Protectors
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    GenScript: all cDNA clones in your preferred vector: RPS18 (NM_022551)
    Sino Biological Human cDNA Clone for RPS18
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RS18_HUMAN, P62269: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    chloroplast2
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005581collagen ----
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--
    GO:0005840ribosome NAS8441687
    GO:0015935small ribosomal subunit IDA15883184

    RPS18 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RPS18 About   (see all 6)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CFTR translational fidelity class I mutations
    CFTR translational fidelity class I mutations 0.60
    Ribosome0.54
    Cytoplasmic Ribosomal Proteins0.60
    2Influenza Viral RNA Transcription and Replication
    Viral mRNA Translation0.94
    Eukaryotic Translation Initiation0.89
    Peptide chain elongation0.94
    Cap-dependent Translation Initiation0.89
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    Formation of a pool of free 40S subunits0.94
    Nonsense-Mediated Decay0.89
    3Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
    Translation initiation complex formation0.91
    Ribosomal scanning and start codon recognition0.91
    Formation of the ternary complex, and subsequently, the 43S complex0.91
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.90
    4Gene Expression
    Gene Expression0.40
    5Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPS18
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPS18
        Cytoplasmic Ribosomal Proteins


    Selected Reactome Pathways for RPS18 (see all 12)
        Peptide chain elongation
    Formation of the ternary complex, and subsequently, the 43S complex
    Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
    Viral mRNA Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit


    1 Kegg Pathway  (Kegg details for RPS18):
        Ribosome


    RPS18 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RPS18
    Interactions:

        Search GeneGlobe Interaction Network for RPS18

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPS18 (P622692, 3 ENSP000003932414) via UniProtKB, MINT, STRING, and/or I2D (see all 924)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPS3P233962, 3, ENSP000002785724MINT-7945693 I2D: score=4 STRING: ENSP00000278572
    RPL8P629172, 3, ENSP000002625844MINT-7945693 I2D: score=3 STRING: ENSP00000262584
    RPS2P158802, 3, ENSP000003418854MINT-6541718 I2D: score=3 STRING: ENSP00000341885
    RPS4XP627012, 3, ENSP000003627444MINT-8395092 I2D: score=1 STRING: ENSP00000362744
    KPNA2P522922, 3MINT-7945693 I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--
    GO:0006415translational termination TAS--

    RPS18 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPS18 (RS18)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RPS18 gene: 
    NM_022551.2  

    Unigene Clusters for RPS18:

    Ribosomal protein S18
    Hs.448854  [show with all ESTs], Hs.627414  [show with all ESTs]
    Unigene Representative Sequences: BM807407, BM455098
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000439602(uc003odp.1) ENST00000474973 ENST00000474626 ENST00000476222(uc010jum.1)
    ENST00000496813 ENST00000490191 ENST00000472218 ENST00000479802
    miRNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat RPS18
      QuantiFast Probe-based Assays in human, mouse, rat RPS18

    Additional mRNA sequence: 

    AY536376.1 BC101786.1 BC101788.1 BC106063.1 X69150.1 

    Selected DOTS entries (see all 89):

    DT.91998585  DT.95377286  DT.100740961  DT.95344519  DT.100740939  DT.100060011  DT.91834101  DT.86996684 
    DT.91814620  DT.120845911  DT.100740909  DT.100740951  DT.91998593  DT.100837312  DT.95376793  DT.97845755 
    DT.121308046  DT.95376571  DT.100740954  DT.421008  DT.95377868  DT.121307918  DT.121308042  DT.95376911 

    Selected AceView cDNA sequences (see all 2732):

    BI261011 AI684960 W04989 AW005354 BU163217 BQ267768 BG756295 AJ709709 
    BE784457 BE464951 BQ055072 AA876519 BQ958546 BF175647 AA587299 AA303579 
    BF129009 AW173609 AW954000 AA081873 CD108525 BU508314 AA372805 BM797265 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RPS18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGTGTTGAG
    RPS18 Expression
    About this image


    RPS18 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Epithelial Cells
             Fetal Matrix Cells Hair Follicle
     
     Hair (Integumentary System)
             Fetal Matrix Cells Hair Follicle
    RPS18 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPS18 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.448854 Hs.627414
        Custom PCR Arrays for RPS18
    Primer
    Products:
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    QuantiFast Probe-based Assays in human, mouse, rat RPS18
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPS18 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rps181 , 5 ribosomal protein S181, 5 91.89(n)1
    100(a)1
      17 (17.98 cM)5
    200841  NM_011296.21  NP_035426.11 
     339519995 
    lizard
    (Anolis carolinensis)
    Reptilia RPS186
    ribosomal protein S18
    99(a)
    1 ↔ 1
    GL343857.1(4617-12076)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rps181 ribosomal protein S18 82.24(n)
    98.03(a)
      549112  NM_001016358.2  NP_001016358.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rps181 ribosomal protein S18 81.58(n)
    98.03(a)
      192300  NM_173234.1  NP_775341.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RpS181 , 3 protein biosynthesis structural
    constituent of more3
    Ribosomal protein S181
    74(a)3
    72.37(n)1
    77.63(a)1
      56F133
    372921  NM_166383.31  NP_725943.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rps-181 , 3 ribosomal protein S133
    rps-181
    76(a)3
    70.61(n)1
    76.32(a)1
      IV(14825803-14826578)3
    1784081  NM_070393.41  NP_502794.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPS18B1 RPS18B 64.55(n)
    71.83(a)
      854982   NP_013686.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PFL1 PFL 70.18(n)
    74.34(a)
      838884  NM_102125.3  NP_173692.1 
    rice
    (Oryza sativa)
    Liliopsida Os07g01737001 Os07g0173700 68.64(n)
    71.71(a)
      4342526  NM_001065542.2  NP_001059007.2 


    ENSEMBL Gene Tree for RPS18 (if available)
    TreeFam Gene Tree for RPS18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RPS18 (see all 36)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs775372931,2
    C--33241675(+) TTAATA/TAATAA 1 -- int10--------
    rs92824851,2
    C--33241682(+) TAAAT-/AAAT  
            
    TTGAA
    1 -- int10--------
    rs105399521,2
    C--33241737(+) TCATG-/TTTA  
            
    TTTAT
    1 -- int10--------
    rs1806795581,2
    --33241740(+) TGTTTA/GTTTAT 1 -- int10--------
    rs1852528691,2
    --33241797(+) TGGTGC/TAATCT 1 -- int10--------
    rs1402696551,2
    --33241806(+) CTTATC/GTCACT 1 -- int10--------
    rs100809291,2
    C--33241851(+) gcacaC/Tgccca 1 -- int10--------
    rs1813117631,2
    --33241922(+) ACTTCC/TGACCT 1 -- int10--------
    rs1503543331,2
    C--33242361(+) CTTGGC/TGCTGG 1 -- int10--------
    rs1474914031,2
    C--33242491(+) TCGTG-/TCTCTCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for RPS18 (33239787 - 33244287 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RPS18:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830634CNV Loss17160897
    nsv830635CNV Loss17160897
    nsv5249CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 180473    OMIM disorders: --

    11 diseases for RPS18:    
    About MalaCards
    bowen-conradi syndrome    pasteurellosis    rhabdomyosarcoma    fanconi's anemia
    influenza    systemic lupus erythematosus    lupus erythematosus    prostate cancer
    prostatitis    breast cancer    malaria

    1 disease from the University of Copenhagen DISEASES database for RPS18:
    Bowen-Conradi syndrome

    RPS18 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RPS18
    Human Genome Epidemiology (HuGE) Navigator: RPS18 (3 documents)

    Export disorders for RPS18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RPS18 gene, integrated from 10 sources (see all 74):
    (articles sorted by number of sources associating them with RPS18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human homolog of ribosomal protein S18. (PubMed id 8441687)1, 2, 3, 9 Chassin D.... Koman A. (Nucleic Acids Res. 1993)
    2. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (PLoS Genet. 2009)
    3. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (PLoS Genet. 2009)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    5. A map of 75 human ribosomal protein genes. (PubMed id 9582194)1, 3 Kenmochi N.... Page D.C. (Genome Res. 1998)
    6. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699)1, 2 Vladimirov S.N.... Otto A. (Eur. J. Biochem. 1996)
    7. Ribosomal protein S18 identified as a cofilin-binding protein by using phage display library. (PubMed id 15532723)1, 9 Kusui K....Suzuki K. (Mol. Cell. Biochem. 2004)
    8. The S18 ribosomal protein is a putative substrate for Ca2+/calmodulin-activated protein kinase II. (PubMed id 12145273)1, 9 Mishra-Gorur K....Castellot J.J. (J. Biol. Chem. 2002)
    9. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)
    10. Structures of the human and Drosophila 80S ribosome. (PubMed id 23636399)2 Anger A.M.... Beckmann R. (Nature 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 6222 HGNC: 10401 AceView: B3GALT4andRPS18andD6S2723E Ensembl:ENSG00000231500 euGenes: HUgn6222
    ECgene: RPS18 Kegg: 6222 H-InvDB: RPS18

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RPS18 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RPS18 gene:
    Search GeneIP for patents involving RPS18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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