RPS18 Gene
protein-coding GIFtS: 55
GCID: GC06P033240
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ribosomal protein S18 (Previous symbol: D6S218E)
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Aliases for RPS18 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Ribosomal Protein S181 2 | | S181 2 | | D6S218E1 2 3 | | 40S Ribosomal Protein S182 | | HKE31 2 | | Rhabdomyosarcoma Antigen MU-RMS-40.212 | | KE-31 2 | | Ke-33 | | KE31 2 | | Ke33 |
Export aliases for RPS18 gene to outside databasesPrevious GC identifers: GC06P033243 GC06P033236 GC06P033232 GC06P033286 GC06P033347 GC06Pf33317 GC06P032981 |
Summaries for RPS18 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for RPS18: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This geneencodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S13P family ofribosomal proteins. It is located in the cytoplasm. The gene product of the E. coli ortholog (ribosomal protein S13)is involved in the binding of fMet-tRNA, and thus, in the initiation of translation. This gene is an ortholog of mouseKe3. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this genedispersed through the genome. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: RS18_HUMAN, P62269Function: Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA (Bysimilarity) Gene Wiki entry for RPS18
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Genomic Views for RPS18 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15 NT_113891.2 NT_167245.1 NT_167247.1 NT_167248.1 NT_167249.1
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the RPS18 gene promoter: ER-alpha TBP p53 AP-1 Olf-1 Meis-1b PPAR-alpha Meis-1a Meis-1 Other transcription factors
Search SABiosciences Chromatin IP Primers for RPS18
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS18 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.32 HGNC cytogenetic band: 6p21.3RPS18 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P033240: view genomic region
(about GC identifiers)
Start:
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33,239,787 bp from pter |
End:
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33,244,287 bp from pter |
Size:
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4,501 bases |
Orientation:
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plus strand |
5 alternative locations:
| Chr6+,ALT_REF_LOCI_2 33,161,393-33,205,075 | Chr6+,ALT_REF_LOCI_3 33,217,712-33,233,244 | Chr6+,ALT_REF_LOCI_5 33,325,045-33,329,478 | | Chr6+,ALT_REF_LOCI_6 33,168,626-33,208,704 | Chr6+,ALT_REF_LOCI_7 33,309,519-33,310,184 |
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Proteins for RPS18 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: RS18_HUMAN, P62269 (See
protein sequence)Recommended Name: 40S ribosomal protein S18 Size: 152 amino acids; 17719 Da
Subcellular location: Cytoplasm
Secondary accessions: P25232 Q5SUJ3 Q6IPF8Explore the universe of human proteins at neXtProt for RPS18: NX_P62269
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P62269 RPS18 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_072045.1 ENSEMBL proteins: ENSP00000393241 ENSP00000434837 Reactome Protein details: P62269 Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
RPS18 for ontologies About GeneDecksing
RPS18 Antibody Products: Assay Products for RPS18: |
Protein
Domains / Families for RPS18 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RPS18 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P62269ProtoNet protein and cluster: P62269 UniProtKB/Swiss-Prot: RS18_HUMAN, P62269Similarity: Belongs to the ribosomal protein S13P family |
Function for RPS18 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: RS18_HUMAN, P62269Function: Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA (Bysimilarity) Genatlas biochemistry entry for RPS18:40S ribosomal protein S18,17kDa
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPS18 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPS18 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for RPS18 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS18  |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
RPS18 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for RPS18: Animal Models: 1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Rps18):
RPS18 for phenotypes About GeneDecksing
|
Pathways & Interactions for RPS18 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
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| 1 | Synthesis of PB1-F2 | | | 2 | Translation initiation complex formation | | | 3 | Metabolism of mRNA | | | 4 | Disease | | | 5 | Generic Transcription Pathway | |
Pathway sources See GeneCards unified pathways Show all pathways
1 GeneGo (Thomson Reuters) Pathway for RPS18 1 BioSystems Pathway for RPS18 
5/32
Reactome Pathways for RPS18 (see all 32)
1
Kegg Pathway (Kegg details for RPS18):
RPS18 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPS18
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
 5/798 Interacting proteins for RPS18 (P622692, 3 ENSP000003932414) via UniProtKB, MINT, STRING, and/or I2D (see all 798)About this table
Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
TAS | -- | | GO:0006412 | translation |
TAS | -- | | GO:0006413 | translational initiation |
TAS | -- | | GO:0006414 | translational elongation |
TAS | -- | | GO:0006415 | translational termination |
TAS | -- |
RPS18 for ontologies About GeneDecksing
|
Drugs & Compounds for RPS18 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for RPS18 Search CenterWatch for drugs/clinical trials and news about RPS18 / RS18 
|
Transcripts for RPS18 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for RPS18 gene: NM_022551.2 Unigene Clusters for RPS18: Ribosomal protein S18 Hs.448854 [show with all ESTs], Hs.627414 [show with all ESTs]Unigene Representative Sequences: BM807407, BM4550988 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000439602(uc003odp.1) ENST00000474973 ENST00000474626 ENST00000476222(uc010jum.1) ENST00000496813 ENST00000490191 ENST00000472218 ENST00000479802
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPS18 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPS18 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RPS18 (NM_022551) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPS18 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS18  |
Additional cDNA sequence: AY536376.1 BC101786.1 BC101788.1 BC106063.1 X69150.1 24/88 DOTS entries (see all 88): DT.91998585 DT.95377286 DT.100740961 DT.95344519 DT.100740939 DT.100060011 DT.91834101 DT.86996684 DT.91814620 DT.120845911 DT.100740909 DT.100740951 DT.91998593 DT.100837312 DT.95376793 DT.97845755 DT.121308046 DT.95376571 DT.100740954 DT.421008 DT.95377868 DT.121307918 DT.121308042 DT.95376911 24/2732 AceView cDNA sequences (see all 2732): BQ052125 BM740319 BM479799 AA196251 BU192597 BQ637309 AI523146 T58679 BI258730 F27525 R74539 BU859066 BG576878 BM786130 BM917341 AA371123 BG519755 AA365750 AI884416 AJ706416 AA864202 BU161545 AJ713489 BG033614 GeneLoc Exon Structure
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Expression for RPS18 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RPS18 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TGGTGTTGAG
About this image See RPS18 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for RPS18
SOURCE GeneReport for Unigene clusters: Hs.448854 Hs.627414 SABiosciences Custom PCR Arrays for RPS18
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPS18 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RPS18 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS18 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS18 |
Orthologs for RPS18 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RPS18 gene from 8/31 species (see all 31) About this table
ENSEMBL Gene Tree for RPS18 (if available) TreeFam Gene Tree for RPS18 (if available)  |
Paralogs for RPS18 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| -- |
Genomic Variants for RPS18 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 6 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for RPS18 (33239787 - 33244287 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for RPS18: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPS18 |
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Disorders
/ Diseases for RPS18 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RPS18 for disorders About GeneDecksing
OMIM gene information: 180473
OMIM disorders: --
12 diseases for RPS18: About MalaCardsbowen-conradi syndrome rhabdomyosarcoma systemic lupus erythematosus pasteurellosis lupus erythematosus fanconi's anemia anemia ovarian carcinoma carcinoma malaria prostate cancer prostatitis 1 disease from the University of Copenhagen DISEASES database for RPS18:Bowen-Conradi syndrome Human Genome Epidemiology (HuGE) Navigator: RPS18 (3 documents) Export disorders for RPS18 gene to outside databases
|
Publications for RPS18 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RPS18 gene, integrated from 9 sources (see all 55): (articles sorted by number of sources associating them with RPS18) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The human homolog of ribosomal protein S18. (PubMed id 8441687)1, 2, 3, 9 Chassin D.... Koman A. (1993)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- A map of 75 human ribosomal protein genes. (PubMed id 9582194)1, 3 Kenmochi N.... Page D.C. (1998)
- Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699)1, 2 Vladimirov S.N.... Otto A. (1996)
- Ribosomal protein S18 identified as a cofilin-binding protein by using phage display library. (PubMed id 15532723)1, 9 Kusui K....Suzuki K. (2004)
- The S18 ribosomal protein is a putative substrate for Ca2+/calmodulin-activated protein kinase II. (PubMed id 12145273)1, 9 Mishra-Gorur K....Castellot J.J. (2002)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- A cohesin-RAD21 interactome. (PubMed id 22145905)1 Panigrahi A.K....Pati D. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
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External Searches for RPS18 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RPS18 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RPS18 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RPS18 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for RPS18 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RPS18 gene: Search GeneIP for patents involving RPS18
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for RPS18 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
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 | |
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 | | RPS18 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | Search ThermoFisher Antibodies for RPS18 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS18 |
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