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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPS17L Gene

protein-coding   GIFtS: 42
GCID: GC15M083202

Ribosomal Protein S17-Like

Microbiology & Infectious Diseases Congress
  Search for RPS17L
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ribosomal Protein S17-Like1 2
40S Ribosomal Protein S17-Like2

External Ids:    HGNC: 400291   Entrez Gene: 1005055032   Ensembl: ENSG000001827747   UniProtKB: P0CW223   

Export aliases for RPS17L gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RPS17L Gene: 
RPS17L (ribosomal protein S17-like) is a protein-coding gene. Among its related super-pathways are Viral mRNA Translation. GO annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is RPS17.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_077661.3  NC_018926.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for RPS17L
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for RPS17L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS17L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Ensembl cytogenetic band:  15q25.2   HGNC cytogenetic band: 15q25.2

RPS17L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS17L gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M083202:  view genomic region     (about GC identifiers)

Start:
83,205,504 bp from pter      End:
83,209,315 bp from pter
Size:
3,812 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RS17L_HUMAN, P0CW22 (See protein sequence)
Recommended Name: 40S ribosomal protein S17-like  
Size: 135 amino acids; 15550 Da

Explore the universe of human proteins at neXtProt for RPS17L: NX_P0CW22

Explore proteomics data for RPS17L at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P0CW22

  • RPS17L Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RPS17L Protein Expression
    REFSEQ proteins: NP_001185986.1  
    ENSEMBL proteins: 
     ENSP00000346046   ENSP00000453910   ENSP00000452889   ENSP00000453894  

    Human Recombinant Protein Products for RPS17L: 
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    Cloud-Clone Corp. Proteins for RPS17L 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol ----
    GO:0005840ribosome IEA--
    GO:0022627cytosolic small ribosomal subunit ----

    RPS17L for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for RPS17L 
    Cloud-Clone Corp. CLIAs for RPS17L


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR018273 Ribosomal_S17e_CS
     IPR001210 Ribosomal_S17e

    Graphical View of Domain Structure for InterPro Entry P0CW22

    ProtoNet protein and cluster: P0CW22

    UniProtKB/Swiss-Prot: RS17L_HUMAN, P0CW22
    Similarity: Belongs to the ribosomal protein S17e family


    RPS17L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome IEA--
         
    RPS17L for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RPS17L:
     Decreased viability of wild-ty  Increased S DNA content 

    Animal Models:
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS17L


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RPS17L About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Viral mRNA Translation
    Cytoplasmic Ribosomal Proteins0.65
    Ribosome0.59

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for RPS17L
        Cytoplasmic Ribosomal Proteins


    1         Kegg Pathway  (Kegg details for RPS17L):
        Ribosome


    RPS17L for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPS17L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/234 Interacting proteins for RPS17L (P0CW222, 3 ENSP000003460464) via UniProtKB, MINT, STRING, and/or I2D (see all 234)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000096150P622692, 3MINT-8395092 I2D: score=3 
    ENSG00000223367P622692, 3MINT-8395092 I2D: score=3 
    ENSG00000226225P622692, 3MINT-8395092 I2D: score=3 
    ENSG00000235650P622692, 3MINT-8395092 I2D: score=3 
    RPS18P622692, 3MINT-8395092 I2D: score=3 
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000028ribosomal small subunit assembly ----
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ----
    GO:0006364rRNA processing ----
    GO:0006412translation IEA--
    GO:0006413translational initiation ----

    RPS17L for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RPS17L (RS17L)

    Search CenterWatch for drugs/clinical trials and news about RPS17L / RS17L

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RPS17L gene: 
    NM_001199057.1  

    Unigene Clusters for RPS17L:

    Ribosomal protein S17-like
    Hs.433427  [show with all ESTs], Hs.512525  [show with all ESTs]
    Unigene Representative Sequences: BM918752, CD049182
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000330244(uc002bio.1) ENST00000560229 ENST00000561157 ENST00000558397
    ENST00000561068 ENST00000560612 ENST00000561440 ENST00000560639 ENST00000559776
    ENST00000559273
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate RPS17L
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    Inhib. RNA
    Products:
         
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    Primer
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      Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS17L

    Additional mRNA sequence: 

    AK311951.1 BC009407.2 BC070222.1 

    24/71 DOTS entries (see all 71):

    DT.95231387  DT.100060125  DT.95378808  DT.100739925  DT.98081977  DT.92469644  DT.92469637  DT.100638918 
    DT.92469626  DT.121021874  DT.100876268  DT.91869254  DT.100739938  DT.100739968  DT.100739953  DT.121021573 
    DT.92469622  DT.91651851  DT.100868623  DT.95252543  DT.121022024  DT.100739912  DT.100739963  DT.121021845 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPS17L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RPS17L Expression
    About this image


    See RPS17L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPS17L

    SOURCE GeneReport for Unigene clusters: Hs.433427 Hs.512525
        SABiosciences Custom PCR Arrays for RPS17L
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS17L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPS17L gene from 8/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves RPS176
    40S ribosomal protein S17
    98(a)
    1 → many
    10(834930-836457)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    99(a)
    possible ortholog
    GL343479.1(636199-639072)
    zebrafish
    (Danio rerio)
    Actinopterygii rps171 ribosomal protein S17 80.7(n)
    93.98(a)
      393818  NM_200845.1  NP_957139.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RpS171 Ribosomal protein S17 72.95(n)
    81.15(a)
      39088  NM_079278.2  NP_524002.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rps-176
    40S ribosomal protein S17
    67(a)
    1 → many
    I(6220089-6220766)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPS17B(YDR447C)4
    RPS17A1
    Ribosomal protein 51 (rp51) of the small (40s) subunit; more4
    Rps17ap1
    63.91(n)1
    69.72(a)1
      4(1355553-1354829)4
    8549841  NP_013688.11  8520584 
     NP_010735.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G052201 40S ribosomal protein S17-2 58.2(n)
    62.7(a)
      815070  NM_126548.4  NP_565320.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g01095001 hypothetical protein 61.16(n)
    64.46(a)
      4331346  NM_001055243.2  NP_001048708.1 
            Species with no ortholog for RPS17L

    ENSEMBL Gene Tree for RPS17L (if available)
    TreeFam Gene Tree for RPS17L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPS17L gene
    RPS171 2  
    2 SIMAP similar genes for RPS17L using alignment to 3 protein entries:     RS17L_HUMAN (see all proteins):
    RPS17    LOC392101

    RPS17L for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    7 SNPs in RPS17L are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1452276301,2
    ----83207975(+) CCCCCA/CACTCG 1 -- int10--------
    rs1421713621,2
    ----83207733(+) GTGACA/GTAACT 2 Y syn10--------
    rs1404528041,2
    ----83207809(+) ATGTGC/GATATA 1 -- int10--------
    rs1467535901,2
    ----83207766(+) GAACAA/GTGAGA 1 -- int10--------
    rs2009726421,2
    ----83210352(+) TTTTTG/TTTTTT 1 -- us2k10--------
    rs1490733651,2
    ----83206751(+) GCAGGC/GAGATT 1 -- int10--------
    rs1457712101,2
    ----83206034(+) TACCCA/CTTAGA 1 -- int10--------

    HapMap Linkage Disequilibrium report for RPS17L (83205504 - 83209315 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for RPS17L (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv33165CNV Loss17666407
    nsv510669CNV Loss20534489
    nsv483125CNV Loss15286789
    nsv428309CNV Gain18775914
    nsv833071CNV Gain17160897
    nsv904446CNV Gain21882294
    nsv471686CNV Gain+Loss15918152
    esv21531CNV Gain+Loss19812545
    nsv9285CNV Gain+Loss18304495
    esv22027CNV Gain+Loss19812545

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPS17L gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with RPS17L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The P-body component USP52/PAN2 is a novel regulator o f HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (2013)
    2. A cohesin-RAD21 interactome. (PubMed id 22145905)1 Panigrahi A.K....Pati D. (2012)
    3. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    4. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    7. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    8. Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (2009)
    9. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 100505503 HGNC: 40029 Ensembl:ENSG00000182774 euGenes: HUgn100505503 ECgene: RPS17L Kegg: 100505503
    H-InvDB: RPS17L

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPS17L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RPS17L gene:
    Search GeneIP for patents involving RPS17L

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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