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RPS17L Gene

protein-coding   GIFtS: 43
GCID: GC15M083202

Ribosomal Protein S17-Like

Microbiology & Infectious Diseases Congress
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribosomal Protein S17-Like1 2
40S Ribosomal Protein S17-Like2
DBA45
RPS175
RPS17L15
RPS17L25

External Ids:    HGNC: 400291   Entrez Gene: 1005055032   Ensembl: ENSG000001827747   OMIM: 1804725   UniProtKB: P0CW223   

Export aliases for RPS17L gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RPS17L Gene:
RPS17L (ribosomal protein S17-like) is a protein-coding gene. Diseases associated with RPS17L include malaria. GO annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is RPS17.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.9  NT_077661.3  NC_018926.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for RPS17L
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPS17L promoter sequence
   Search Chromatin IP Primers for RPS17L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPS17L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Ensembl cytogenetic band:  15q25.2   HGNC cytogenetic band: 15q25.2

RPS17L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS17L gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M083202:  view genomic region     (about GC identifiers)

Start:
83,205,504 bp from pter      End:
83,209,315 bp from pter
Size:
3,812 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RS17L_HUMAN, P0CW22 (See protein sequence)
Recommended Name: 40S ribosomal protein S17-like  
Size: 135 amino acids; 15550 Da

Explore the universe of human proteins at neXtProt for RPS17L: NX_P0CW22

Explore proteomics data for RPS17L at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys19, Lys49, Lys59, Lys72, Lys107, Lys129
  • Modification sites at PhosphoSitePlus

  • See RPS17L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001185986.1  
    ENSEMBL proteins: 
     ENSP00000346046   ENSP00000453910   ENSP00000452889   ENSP00000453894  

    RPS17L Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR018273 Ribosomal_S17e_CS
     IPR001210 Ribosomal_S17e

    Graphical View of Domain Structure for InterPro Entry P0CW22

    ProtoNet protein and cluster: P0CW22

    UniProtKB/Swiss-Prot: RS17L_HUMAN, P0CW22
    Similarity: Belongs to the ribosomal protein S17e family


    RPS17L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    RPS17L for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RPS17L:
     Decreased viability of wild-ty  Increased S DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RPS17L
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    miRNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol ----
    GO:0005840ribosome IEA--
    GO:0022627cytosolic small ribosomal subunit ----

    RPS17L for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RPS17L About    
    See pathways by source

    SuperPathContained pathways About
    1CFTR translational fidelity class I mutations
    Cytoplasmic Ribosomal Proteins0.60
    Ribosome0.54

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for RPS17L
        Cytoplasmic Ribosomal Proteins


    1 Kegg Pathway  (Kegg details for RPS17L):
        Ribosome


    RPS17L for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RPS17L
    Interactions:

        Search GeneGlobe Interaction Network for RPS17L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RPS17L (P0CW222, 3 ENSP000003460464) via UniProtKB, MINT, STRING, and/or I2D (see all 346)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NAT10Q9H0A02, 3, ENSP000002578294MINT-8395092 I2D: score=2 STRING: ENSP00000257829
    RPS4XP627012, 3, ENSP000003627444MINT-8395092 I2D: score=2 STRING: ENSP00000362744
    RPL12P300502, 3, ENSP000003547394MINT-8395092 I2D: score=1 STRING: ENSP00000354739
    RPS16P622492, 3, ENSP000002514534MINT-8395092 I2D: score=1 STRING: ENSP00000251453
    SLC25A3Q003252, 3MINT-8395092 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000028ribosomal small subunit assembly ----
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ----
    GO:0006364rRNA processing ----
    GO:0006412translation IEA--
    GO:0006413translational initiation ----

    RPS17L for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPS17L (RS17L)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RPS17L gene: 
    NM_001199057.1  

    Unigene Clusters for RPS17L:

    Ribosomal protein S17-like
    Hs.433427  [show with all ESTs], Hs.512525  [show with all ESTs]
    Unigene Representative Sequences: BM918752, CD049182
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000330244(uc002bio.1) ENST00000560229 ENST00000561157 ENST00000558397
    ENST00000561068 ENST00000560612 ENST00000561440 ENST00000560639 ENST00000559776
    ENST00000559273
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RPS17L
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    Primer
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      Search QuantiFast Probe-based Assays in human, mouse, rat RPS17L

    Additional mRNA sequence: 

    AK311951.1 BC009407.2 BC070222.1 

    Selected DOTS entries (see all 71):

    DT.95231387  DT.100060125  DT.95378808  DT.100739925  DT.98081977  DT.92469644  DT.92469637  DT.100638918 
    DT.92469626  DT.121021874  DT.100876268  DT.91869254  DT.100739938  DT.100739968  DT.100739953  DT.121021573 
    DT.92469622  DT.91651851  DT.100868623  DT.95252543  DT.121022024  DT.100739912  DT.100739963  DT.121021845 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RPS17L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RPS17L Expression
    About this image

    RPS17L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPS17L Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.433427 Hs.512525
        Custom PCR Arrays for RPS17L
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS17L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RPS17L gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves RPS176
    Gallus gallus ribosomal protein S17-like (RPS17L),...
    98(a)
    1 → many
    10(834930-836457)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    99(a)
    1 → many
    GL343479.1(636199-639072)
    zebrafish
    (Danio rerio)
    Actinopterygii RPS17L6
    ribosomal protein S17-like
    98(a)
    1 → many
    25(241974-248867) ENSDARG00000046157
    fruit fly
    (Drosophila melanogaster)
    Insecta RpS176
    Ribosomal protein S17
    77(a)
    1 → many
    3L(9421895-9422921)
    worm
    (Caenorhabditis elegans)
    Secernentea rps-176
    Protein RPS-17 (rps-17) mRNA, complete cds
    69(a)
    1 → many
    I(6220089-6220764) WBGene00004486
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPS17B(YDR447C)4 Ribosomal protein 51 (rp51) of the small (40s) subunit; more   --   4(1355553-1354829) 852058  NP_010735.1 
            Species with no ortholog for RPS17L

    ENSEMBL Gene Tree for RPS17L (if available)
    TreeFam Gene Tree for RPS17L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RPS17L gene
    RPS172  
    2 SIMAP similar genes for RPS17L using alignment to 3 protein entries:     RS17L_HUMAN (see all proteins):
    RPS17    LOC392101

    RPS17L for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    7 SNPs for RPS17L    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1452276301,2
    ----83207975(+) CCCCCA/CACTCG 1 -- int10--------
    rs1421713621,2
    ----83207733(+) GTGACA/GTAACT 2 Y syn10--------
    rs1404528041,2
    ----83207809(+) ATGTGC/GATATA 1 -- int10--------
    rs1467535901,2
    ----83207766(+) GAACAA/GTGAGA 1 -- int10--------
    rs2009726421,2
    ----83210352(+) TTTTTG/TTTTTT 1 -- us2k10--------
    rs1490733651,2
    ----83206751(+) GCAGGC/GAGATT 1 -- int10--------
    rs1457712101,2
    ----83206034(+) TACCCA/CTTAGA 1 -- int10--------

    HapMap Linkage Disequilibrium report for RPS17L (83205504 - 83209315 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RPS17L (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv33165CNV Loss17666407
    nsv510669CNV Loss20534489
    nsv483125CNV Loss15286789
    nsv428309CNV Gain18775914
    nsv833071CNV Gain17160897
    nsv904446CNV Gain21882294
    nsv471686CNV Gain+Loss15918152
    esv21531CNV Gain+Loss19812545
    nsv9285CNV Gain+Loss18304495
    esv22027CNV Gain+Loss19812545

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 180472   
    OMIM disorders: 612527  
    1 disease for RPS17L:    
    About MalaCards
    malaria


    RPS17L for disorders           About GeneDecksing


    Export disorders for RPS17L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RPS17L gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with RPS17L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (Biochem. J. 2013)
    2. A cohesin-RAD21 interactome. (PubMed id 22145905)1 Panigrahi A.K....Pati D. (Biochem. J. 2012)
    3. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    4. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    6. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    7. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    8. Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (Mol. Cell. Proteomics 2009)
    9. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 100505503 HGNC: 40029 Ensembl:ENSG00000182774 euGenes: HUgn100505503 ECgene: RPS17L Kegg: 100505503
    H-InvDB: RPS17L

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RPS17L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RPS17L gene:
    Search GeneIP for patents involving RPS17L

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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