RPS17 Gene
protein-coding GIFtS : 64 GCID: GC15 M082821
Ribosomal Protein S17
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Aliasesfor RPS17 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
10 fRNAdb ,
12 H-InvDB ,
13 NCBI ,
14 NONCODE ,
and/or 15 RNAdb )About This Section Aliases Ribosomal Protein S17 1 2 40S Ribosomal Protein S172 DBA42 5 RPS17L2 RPS17L12 5 S172 RPS17L22 5
Export aliases for RPS17 gene to outside databases Previous GC identifers: GC15M079008 GC15M076138 GC15M080395 GC15M080536 GC15M080608 GC15M059476
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Summariesfor RPS17 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for RPS17 Gene: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S17E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. (provided by RefSeq, Jul 2008) GeneCards Summary for RPS17 Gene: RPS17 (ribosomal protein S17) is a protein-coding gene. Diseases associated with RPS17 include rps17-related diamond-blackfan anemia diamond-blackfan anemia related super-pathways are Eukaryotic Translation Initiation and Formation of the ternary complex, and subsequently, the 43S complex . GO annotations related to this gene include structural constituent of ribosome . An important paralog of this gene is RPS17L . Gene Wiki entry for RPS17 Gene
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Genomic Viewsfor RPS17 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 73) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the RPS17 gene promoter:COUP-TF1 COUP HNF-4alpha2 E4BP4 HNF-4alpha1 HNF-1A S8 COUP-TF HNF-1 RSRFC4 Other transcription factors Search SABiosciences Chromatin IP Primers for RPS17 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS17
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 15q Ensembl cytogenetic band: 15q25.2 HGNC cytogenetic band: 15q RPS17 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 15 GeneLoc Exon Structure
GeneLoc location for GC15M082821: view genomic region
(about GC identifiers )
Start: 82,821,158 bp from pter End:
82,824,972 bp from pter
Size: 3,815 bases Orientation:
minus strand
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Proteinsfor RPS17 gene
(According to
UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE 1 MOPED ,
2 PaxDb , and 3 MAXQB
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Cloud-Clone Corp. ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Cloud-Clone Corp. ,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
LSBio ,
Abcam , and/or
Cloud-Clone Corp. )
About This Section UniProtKB/Swiss-Prot: RS17_HUMAN, P08708 See
protein sequence )Recommended Name: Size : 135 amino acids; 15550 Da1 PDB 3D structure from :3J3A (3D) Secondary accessions : B2R4U4Explore the universe of human proteins at neXtProt for RPS17: NX_P08708 Explore proteomics data for RPS17 at MOPED Post-translational modifications:
View modification sites using PhosphoSitePlus View neXtProt modification sites for NX_P08708 RPS17 Protein expression data from MOPED1 2 3 : About this image REFSEQ proteins: NP_001012.1 ENSEMBL proteins: ENSP00000346045 ENSP00000453564 ENSP00000452655 ENSP00000452696 Reactome Protein details: P08708 Human Recombinant Protein Products for RPS17: Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view) : About this table
About GeneDecksing RPS17 Antibody Products: Assay Products for RPS17:
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Protein
Domains /for RPS17 gene (According to HGNC , IUPHAR , InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section HGNC Gene Families: RPS: S ribosomal proteins 2 InterPro protein domains :
Graphical View of Domain Structure for InterPro Entry P08708 ProtoNet protein and cluster: P08708
1 Blocks protein domain : IPB001210 UniProtKB/Swiss-Prot: RS17_HUMAN, P08708 Similarity : Belongs to the ribosomal protein S17e familyAbout GeneDecksing
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Functionfor RPS17 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene .)
About This Section Molecular Function: Genatlas biochemistry entry for RPS17 40S ribosomal protein S17,15kDa Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003735 structural constituent of ribosome
NAS 17647292
About GeneDecksing Phenotypes: 4 GenomeRNAi human phenotypes for RPS17 :Animal Models: In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS17
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Pathways & Interactionsfor RPS17 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Sino Biological ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene) .
About This Section SuperPaths for RPS17 About (see all 6 ) See pathways by source SuperPath Selected contained pathways About (see all per SuperPath ) 1 Viral mRNA Translation 2 Translation initiation complex formation 3 Metabolism of mRNA 4 Generic Transcription Pathway 5 Asparagine N-linked glycosylation
Pathways by source See SuperPaths Show all pathways 1 1 5/27 (see all 27 )1 (Kegg details for RPS17) :About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPS17 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/264 Interacting proteins for RPS17 (P08708 2 , 3 ENSP00000346045 4 via UniProtKB, MINT, STRING , and/or I2D (see all 264 )About this table Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17 ): About this table
About GeneDecksing
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Drugs & Compoundsfor RPS17 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
IUPHAR ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for RPS17 (RS17) RPS17 / RS17
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Transcriptsfor RPS17 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , KenesGroup ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for RPS17 gene: NM_001021.3 10 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000330339 (uc002bhr.1 uc021ssu.1 ) ENST00000560151 ENST00000559187 ENST00000560826 ENST00000560977 ENST00000559636 ENST00000560084 ENST00000560652 ENST00000559854 ENST00000560024 Congresses - knowledge worth sharing: European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014 Primer RPS17 SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat
24/2925 AceView cDNA sequences (see all 2925 ):
BQ684363 AA357036 AA187482 BU175826 CB109632 AA112000 BE257074 BG767794 BF794220 BE901795 BQ231150 BC020453 BG338952 BE294800 BE389686 BC062715 BQ681767 BM760276 AA303775 AJ710727 BU152848 AA583102 AA296571 BM465031 GeneLoc Exon Structure
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Expression for RPS17 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section RPS17 expression in normal human tissues
(normalized intensities) RPS17 embryonic expression: see See probesets specificity/sensitivity at GeneAnnot About this image BioGPS 2/3 CGAP TAG: GGCCGCGTTCAbout this image
RPS17 expression in embryonic tissues and stem cells About this table LifeMap ,
the Embryonic Development and Stem Cells Database 5/3 selected tissues (see all 3 ) fully expand See RPS17 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for RPS17 SABiosciences Custom PCR Arrays for RPS17 Primer RPS17 SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS17
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Orthologsfor RPS17 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for RPS17 gene from 10/26 species (see all 26 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
mouse Mammalia Rps175
ribosomal protein S17
--
7 (45.71 cM) 81342732
chicken Aves RPS176
40S ribosomal protein S17
98(a)
1 → many
10(834930-836457)
lizard Reptilia --
Uncharacterized protein
99(a)
possible ortholog
GL343479.1(636199-639072)
African clawed frog Amphibia Xl.83372
Xenopus laevis transcribed sequence with strong similarity more
79.49(n)
CB943667.1
zebrafish Actinopterygii BQ418878.12
--
83(n)
BQ418878.1
fruit fly Insecta RpS171 3
protein biosynthesis structural constituentmore 3 1
79(a) 3 72.95(n) 1 81.15(a) 1
3 67B43 39088 1 NM_079278.2 1 NP_524002.1 1
worm Secernentea rps-173
40S ribosomal protein S17
71(a)
I(6228214-6228815) --
baker's yeast Saccharomycetes RPS17B(YDR447C)4 1
Ribosomal protein 51 (rp51) of the small (40s) subunit; more 4 1
63.91(n) 1 69.72(a) 1
4(1355553-1354829) 4 854984 1 NP_013688.1 1 852058 4 NP_010735.1 4
thale cress eudicotyledons AT2G052201
40S ribosomal protein S17-2
58.2(n) 62.7(a)
815070 NM_126548.4 NP_565320.1
rice Liliopsida Os.463712
Transcribed sequence with weak similarity to protein more
71.13(n)
CB966919.1
ENSEMBL Gene Tree for RPS17 (if available)TreeFam Gene Tree for RPS17 (if available)
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Paralogsfor RPS17 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for RPS17 gene RPS17L 1 2 2 SIMAP similar genes for RPS17 using alignment to 2 protein entries: RS17_HUMAN (see all proteins ):RPS17L LOC392101 About GeneDecksing 5/26 Pseudogenes.org Pseudogenes for RPS17 (see all 26 )PGOHUM00000242480 PGOHUM00000247171 PGOHUM00000237351 PGOHUM00000244323 PGOHUM00000262142
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Genomic Variantsfor RPS17 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
4 UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 15 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for RPS17 (82821158 - 82824972 bp)
Structural Variations Database of Genomic Variants (DGV) 10/13 variations for RPS17 (see all 13 ): About this table Human Gene Mutation Database (HGMD) : RPS17 Locus Specific Mutation Databases (LSDB): RPS17 SABiosciences Cancer Mutation PCR Assays
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Disorders
/ Diseasesfor RPS17 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Conferences by KenesGroup ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 180472 OMIM disorders : 612527 UniProtKB/Swiss-Prot: RS17_HUMAN, P08708 Diamond-Blackfan anemia 4 (DBA4) [MIM:612527]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of developing leukemia. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. Note=The disease is caused by mutations affecting the gene represented in this entry 16 : About MalaCards rps17-related diamond-blackfan anemia diamond-blackfan anemia macrocytic anemia pure red-cell aplasia reactive arthritis hepatitis e aplastic anemia cleft palate anemia short stature macular degeneration ataxia influenza arthritis leukemia hepatitis 1 disease from the University of Copenhagen DISEASES database for RPS17 :Aplastic anemia GeneTests: RPS17 Diamond-Blackfan Anemia Genetic Association Database (GAD): RPS17 Human Genome Epidemiology (HuGE) Navigator: RPS17 (2 documents) Export disorders for RPS17 gene to outside databases
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Publicationsfor RPS17 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for RPS17 gene, integrated from 9 sources (see all 69 ):(articles sorted by number of sources associating them with RPS17) Utopia : connect your pdf to the dynamic
[Mapping the genes for ribosomal proteins S14 and S17 on human chromosomes using cDNA from a panel of hybrid cells] (PubMed id 7661859) 1 , 3, 9(1995) Mutations in the ribosomal protein genes in Japanese patients with Diamond-Blackfan anemia. (PubMed id 20378560) 1 , 4(2010) Ribosomal protein L5 and L11 mutations are associated with cleft palate and abnormal thumbs in Diamond-Blackfan anemia patients. (PubMed id 19061985) 1 , 2 (2008) Ribosomal protein S17 gene (RPS17) is mutated in Diamond-Blackfan anemia. (PubMed id 17647292) 1 , 2 (2007) Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171) 1 , 2 (2006) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 (2004) Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699) 1 , 2 (1996) The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in the human genome. (PubMed id 1577483) 1 , 3(1992) The transcriptionally active human ribosomal protein S17 gene. (PubMed id 3240863) 1 , 2 (1988)
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External Searches for RPS17 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing RPS17 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing RPS17 gene
(According to HUGE )
About This Section --
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Specialized Databases showing RPS17 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for RPS17 Pharmacogenomics, SNPs, Pathways Diamond-Blackfan Anemia mutation database http://www.dbagenes.unito.it/home.php?select_db=RPS17
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About This Section Patent Information for RPS17 gene: RPS17 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor RPS17 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Cloud-Clone Corp. , Thermo Fisher Scientific , LSBio , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RPS17 Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPS17 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS17 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS17
Search ThermoFisher Antibodies for RPS17
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RPS17
LSBio Antibodies in human mouse rat
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Aliases for RPS17
Databases for RPS17
Disorders / Diseases for RPS17
Domains / Families for RPS17
Drugs / Compounds for RPS17
Expression for RPS17
Function for RPS17
Genomic Views for RPS17
Intellectual Property for RPS17
Orthologs for RPS17
Paralogs for RPS17
Pathways / Interactions for RPS17
Products for RPS17
Proteins for RPS17
Publications for RPS17
Search Box for RPS17
Summaries for RPS17
Transcripts for RPS17
Variants for RPS17
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and Proteopedia 
for RPS17:
GeneGo (Thomson Reuters) Pathway for RPS17
BioSystems Pathway for RPS17
Kegg Pathway 
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