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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPS17 Gene

protein-coding   GIFtS: 64
GCID: GC15M082821

Ribosomal Protein S17

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ribosomal Protein S171 2     40S Ribosomal Protein S172
DBA42 5     RPS17L2
RPS17L12 5     S172
RPS17L22 5     

External Ids:    HGNC: 103971   Entrez Gene: 62182   Ensembl: ENSG000001847797   OMIM: 1804725   UniProtKB: P087083   

Export aliases for RPS17 gene to outside databases

Previous GC identifers: GC15M079008 GC15M076138 GC15M080395 GC15M080536 GC15M080608 GC15M059476


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RPS17 Gene:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This
gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S17E family
of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there
are multiple processed pseudogenes of this gene dispersed through the genome. (provided by RefSeq, Jul 2008)

GeneCards Summary for RPS17 Gene: 
RPS17 (ribosomal protein S17) is a protein-coding gene. Diseases associated with RPS17 include rps17-related diamond-blackfan anemia, and diamond-blackfan anemia, and among its related super-pathways are Eukaryotic Translation Initiation and Formation of the ternary complex, and subsequently, the 43S complex. GO annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is RPS17L.

Gene Wiki entry for RPS17 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPS17 gene promoter:
         COUP-TF1   COUP   HNF-4alpha2   E4BP4   HNF-4alpha1   HNF-1A   S8   COUP-TF   HNF-1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPS17 promoter sequence
   Search SABiosciences Chromatin IP Primers for RPS17

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q   Ensembl cytogenetic band:  15q25.2   HGNC cytogenetic band: 15q

RPS17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS17 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M082821:  view genomic region     (about GC identifiers)

Start:
82,821,158 bp from pter      End:
82,824,972 bp from pter
Size:
3,815 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RS17_HUMAN, P08708 (See protein sequence)
Recommended Name: 40S ribosomal protein S17  
Size: 135 amino acids; 15550 Da
1 PDB 3D structure from and Proteopedia for RPS17:
3J3A (3D)    
Secondary accessions: B2R4U4

Explore the universe of human proteins at neXtProt for RPS17: NX_P08708

Explore proteomics data for RPS17 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P08708

  • RPS17 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RPS17 Protein Expression
    REFSEQ proteins: NP_001012.1  
    ENSEMBL proteins: 
     ENSP00000346045   ENSP00000453564   ENSP00000452655   ENSP00000452696  
    Reactome Protein details: P08708
    Human Recombinant Protein Products for RPS17: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals RPS17 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RPS17 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--
    GO:0005840ribosome NAS3240863
    GO:0022627cytosolic small ribosomal subunit ISS--

    RPS17 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for RPS17 
    Cloud-Clone Corp. CLIAs for RPS17


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RPS: S ribosomal proteins

    2 InterPro protein domains:
     IPR018273 Ribosomal_S17e_CS
     IPR001210 Ribosomal_S17e

    Graphical View of Domain Structure for InterPro Entry P08708

    ProtoNet protein and cluster: P08708

    1 Blocks protein domain: IPB001210 Ribosomal protein S17e

    UniProtKB/Swiss-Prot: RS17_HUMAN, P08708
    Similarity: Belongs to the ribosomal protein S17e family


    RPS17 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for RPS17:
    40S ribosomal protein S17,15kDa

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome NAS17647292
         
    RPS17 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for RPS17:
     Cytoplasmic 40S maturation def  Decreased viability  Increased S DNA content  Nucleolar pre-40S maturation d 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RPS17 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RPS17

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RPS17 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RPS17 

    miRNA
    Products:
        
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate RPS17
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RPS17
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    Gene Editing
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    Clone
    Products:
         
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    OriGene clones in human, mouse for RPS17 (see all 5)
    OriGene ORF clones in mouse, rat for RPS17
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RPS17 (NM_001021)
    Sino Biological Human cDNA Clone for RPS17
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RPS17
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS17
    Sirion Biotech Customized lentivirus for stable overexpression of RPS17 
                         Customized lentivirus expression plasmids for stable overexpression of RPS17 

    Cell Line
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    Search LifeMap BioReagents cell lines for RPS17
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS17


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RPS17 About   (see all 6)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Viral mRNA Translation
    Influenza Life Cycle0.95
    3' -UTR-mediated translational regulation0.93
    Influenza Infection0.95
    L13a-mediated translational silencing of Ceruloplasmin expression0.93
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Formation of a pool of free 40S subunits0.90
    Eukaryotic Translation Termination0.94
    Nonsense-Mediated Decay0.84
    2Translation initiation complex formation
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.95
    Formation of the ternary complex, and subsequently, the 43S complex0.87
    Ribosomal scanning and start codon recognition0.95
    Translation initiation complex formation0.87
    3Metabolism of mRNA
    Metabolism of mRNA0.92
    Metabolism of RNA0.92
    4Generic Transcription Pathway
    Gene Expression0.47
    5Asparagine N-linked glycosylation
    Metabolism of proteins0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPS17
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPS17
        Cytoplasmic Ribosomal Proteins


    5/27        Reactome Pathways for RPS17 (see all 27)
        Formation of the ternary complex, and subsequently, the 43S complex
    Nonsense Mediated Decay Independent of the Exon Junction Complex
    Nonsense-Mediated Decay
    Translation
    SRP-dependent cotranslational protein targeting to membrane


    1         Kegg Pathway  (Kegg details for RPS17):
        Ribosome


    RPS17 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPS17

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    263/264 Interacting proteins for RPS17 (P087082, 3 ENSP000003460454) via UniProtKB, MINT, STRING, and/or I2D (see all 264) (see top 5)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPS16P622492, 3, ENSP000002514534MINT-8044024 I2D: score=1 STRING: ENSP00000251453
    MAP3K14Q995582, 3MINT-48887 I2D: score=2 
    RPS26P628542, 3MINT-8044024 I2D: score=1 
    ENSG00000096150P622693I2D: score=3 
    ENSG00000223367P622693I2D: score=3 
    ENSG00000226225P622693I2D: score=3 
    ENSG00000235650P622693I2D: score=3 
    RPS18P622693I2D: score=3 
    RPS14P622632, 3, ENSP000003110284MINT-8044024 I2D: score=2 STRING: ENSP00000311028
    RPS11P622802, 3, ENSP000002706254MINT-8044024 I2D: score=1 STRING: ENSP00000270625
    RPS12P253982, 3, ENSP000002300504MINT-8044024 I2D: score=2 STRING: ENSP00000230050
    RPL26P612543, ENSP000002938424I2D: score=4 STRING: ENSP00000293842
    RPL26L1Q9UNX33, ENSP000002651004I2D: score=4 STRING: ENSP00000265100
    RPL35P427663, ENSP000002594694I2D: score=4 STRING: ENSP00000259469
    BYSLQ138953, ENSP000002303404I2D: score=2 STRING: ENSP00000230340
    NOP58Q9Y2X33, ENSP000002642794I2D: score=2 STRING: ENSP00000264279
    RPL34P492073, ENSP000003781604I2D: score=2 STRING: ENSP00000378160
    RPS24P628473, ENSP000004143214I2D: score=2 STRING: ENSP00000414321
    RPS3AP612473, ENSP000003460504I2D: score=2 STRING: ENSP00000346050
    RPS4XP627013, ENSP000003627444I2D: score=2 STRING: ENSP00000362744
    RPS8P622413, ENSP000003798884I2D: score=2 STRING: ENSP00000379888
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    RIOK2Q9BVS43, ENSP000002831094I2D: score=1 STRING: ENSP00000283109
    RPL11P629133, ENSP000003636764I2D: score=1 STRING: ENSP00000363676
    RPL13P263733, ENSP000003078894I2D: score=1 STRING: ENSP00000307889
    RPL13AP404293, ENSP000003757304I2D: score=1 STRING: ENSP00000375730
    RPL17P186213I2D: score=1 
    RPL17-C18orf32P186213I2D: score=1 
    RPL27P613533, ENSP000002537884I2D: score=1 STRING: ENSP00000253788
    RPL27AP467763, ENSP000003460154I2D: score=1 STRING: ENSP00000346015
    RPL3P390233, ENSP000003460014I2D: score=1 STRING: ENSP00000346001
    RPL30P628883, ENSP000002870384I2D: score=1 STRING: ENSP00000287038
    RPL6Q028783, ENSP000002027734I2D: score=1 STRING: ENSP00000202773
    RPS13P622773, ENSP000002281404I2D: score=1 STRING: ENSP00000228140
    RPS15AP622443, ENSP000003186464I2D: score=1 STRING: ENSP00000318646
    RPS23P622663, ENSP000002966744I2D: score=1 STRING: ENSP00000296674
    RPS3P233963, ENSP000002785724I2D: score=1 STRING: ENSP00000278572
    UBE2D2P628373, ENSP000003817174I2D: score=1 STRING: ENSP00000381717
    ETF1P624953, ENSP000003537414I2D: score=1 STRING: ENSP00000353741
    RPL15P613133, ENSP000003093344I2D: score=1 STRING: ENSP00000309334
    RPL37AP615133, ENSP000004180824I2D: score=2 STRING: ENSP00000418082
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    RPS29P622732, ENSP000003793394MINT-8044024 STRING: ENSP00000379339
    RPS5P467823, ENSP000001965514I2D: score=1 STRING: ENSP00000196551
    RPS6P627533, ENSP000003697574I2D: score=4 STRING: ENSP00000369757
    RPS7P620813, ENSP000003390954I2D: score=1 STRING: ENSP00000339095
    RPS20P608662, ENSP000000095894MINT-8044024 STRING: ENSP00000009589
    RPS19P390192, ENSP000002219754MINT-8044024 STRING: ENSP00000221975
    UBE2D1P516683, ENSP000003630194I2D: score=1 STRING: ENSP00000363019
    RPF2Q9H7B23, ENSP000004023384I2D: score=1 STRING: ENSP00000402338
    RPL8P629173, ENSP000002625844I2D: score=2 STRING: ENSP00000262584
    RPL18AQ025433, ENSP000002222474I2D: score=2 STRING: ENSP00000222247
    RPL4P365783, ENSP000003114304I2D: score=2 STRING: ENSP00000311430
    RPL7AP624243, ENSP000003610764I2D: score=1 STRING: ENSP00000361076
    RPL12P300503, ENSP000003547394I2D: score=1 STRING: ENSP00000354739
    RPL18Q070203, ENSP000000847954I2D: score=1 STRING: ENSP00000084795
    RPL35AP180773, ENSP000003933934I2D: score=1 STRING: ENSP00000393393
    CLUAP1Q96AJ13I2D: score=5 
    NR5A2O004823I2D: score=5 
    RPL36AP838813I2D: score=3 
    CSNK1EP496743I2D: score=2 
    HEATR1Q9H5833I2D: score=2 
    NAT10Q9H0A03I2D: score=2 
    NME2P223923I2D: score=2 
    NOB1Q9ULX33I2D: score=2 
    NOC4LQ9BVI43I2D: score=2 
    NOL6Q9H6R43I2D: score=2 
    PWP2Q152693I2D: score=2 
    RPL10AP629063I2D: score=2 
    RPS17LP0CW223I2D: score=2 
    RPS27AP629793I2D: score=2 
    RPSAP088653I2D: score=2 
    TSR1Q2NL823I2D: score=2 
    TTC37Q6PGP73I2D: score=2 
    VCPP550723I2D: score=2 
    AMBRA1Q9C0C73I2D: score=1 
    AP2B1P630103I2D: score=1 
    APCP250543I2D: score=1 
    ARF1P840773I2D: score=1 
    ARRB1P494073I2D: score=1 
    ARRB2P321213I2D: score=1 
    ATG14Q6ZNE53I2D: score=1 
    ATG16L1Q676U53I2D: score=1 
    BMS1Q146923I2D: score=1 
    CCNHP519463I2D: score=1 
    CDK7P506133I2D: score=1 
    CEBPZQ037013I2D: score=1 
    CHN2P527573I2D: score=1 
    CLN3Q132863I2D: score=1 
    CNBPP626333I2D: score=1 
    COPG2Q9UBF23I2D: score=1 
    CPSF1Q105703I2D: score=1 
    CRLS1Q9UJA23I2D: score=1 
    CTPS1P178123I2D: score=1 
    DDA1Q9BW613I2D: score=1 
    EIF2DP412143I2D: score=1 
    EPS15L1Q9UBC23I2D: score=1 
    ESDP107683I2D: score=1 
    FOSP011003I2D: score=1 
    FOXO3O435243I2D: score=1 
    GABARAPO951663I2D: score=1 
    GABARAPL1Q9H0R83I2D: score=1 
    GNL3Q9BVP23I2D: score=1 
    GRB7Q144513I2D: score=1 
    GTPBP3Q969Y23I2D: score=1 
    HDAC1Q135473I2D: score=1 
    KBTBD7Q8WVZ93I2D: score=1 
    KLHDC10Q6PID83I2D: score=1 
    MAP1LC3AQ9H4923I2D: score=1 
    MAP3K4Q9Y6R43I2D: score=1 
    NAA10P412273I2D: score=1 
    NSFP464593I2D: score=1 
    NSMAFQ926363I2D: score=1 
    OXA1LQ150703I2D: score=1 
    PDPK1O155303I2D: score=1 
    PELOQ9BRX23I2D: score=1 
    PPA1Q151813I2D: score=1 
    PPCSQ9HAB83I2D: score=1 
    PPP1CCP368733I2D: score=1 
    PRKAA1Q131313I2D: score=1 
    PRKAA2P546463I2D: score=1 
    PRKAB2O437413I2D: score=1 
    PRKAG1P546193I2D: score=1 
    PRKAG2Q9UGJ03I2D: score=1 
    PRKAR1AP106443I2D: score=1 
    PSMD14O004873I2D: score=1 
    PSMD2Q132003I2D: score=1 
    PSMD4P550363I2D: score=1 
    RABGAP1Q9Y3P93I2D: score=1 
    RBL1P287493I2D: score=1 
    RFC5P409373I2D: score=1 
    RPL10P276353I2D: score=1 
    RPL14P509143I2D: score=1 
    RPL19P840983I2D: score=1 
    RPL21P467783I2D: score=1 
    RPL32P629103I2D: score=1 
    RPL7P181243I2D: score=1 
    RPS15P628413I2D: score=1 
    SACM1LQ9NTJ53I2D: score=1 
    SEC31AO949793I2D: score=1 
    SH3GLB2Q9NR463I2D: score=1 
    SLC25A3Q003253I2D: score=1 
    SLC2A4P146723I2D: score=1 
    TADA2AO754783I2D: score=1 
    TBPP202263I2D: score=1 
    UBA5Q9GZZ93I2D: score=1 
    ULK1O753853I2D: score=1 
    ULK2Q8IYT83I2D: score=1 
    WIPI2Q9Y4P83I2D: score=1 
    RPS21P632202MINT-8044024
    RPS25P628512MINT-8044024
    RPS28P628572MINT-8044024
    EEF2ENSP000003079404STRING: ENSP00000307940
    EIF2S1ENSP000002563834STRING: ENSP00000256383
    EIF2S2ENSP000003641194STRING: ENSP00000364119
    EIF3BENSP000003541254STRING: ENSP00000354125
    EIF3DENSP000002161904STRING: ENSP00000216190
    EIF3EENSP000002208494STRING: ENSP00000220849
    EIF3FENSP000003100404STRING: ENSP00000310040
    EIF3GENSP000002531084STRING: ENSP00000253108
    EIF3HENSP000002766824STRING: ENSP00000276682
    EIF3IENSP000003626884STRING: ENSP00000362688
    EIF3KENSP000002483424STRING: ENSP00000248342
    EIF4EENSP000002808924STRING: ENSP00000280892
    EIF4G1ENSP000003168794STRING: ENSP00000316879
    EIF5BENSP000002893714STRING: ENSP00000289371
    INS-IGF2ENSP000003489864STRING: ENSP00000348986
    RBM8AENSP000003330014STRING: ENSP00000333001
    RPL22ENSP000003460884STRING: ENSP00000346088
    RPL23ENSP000003778654STRING: ENSP00000377865
    RPL28ENSP000004014504STRING: ENSP00000401450
    RPL31ENSP000003867174STRING: ENSP00000386717
    RPL37ENSP000002742424STRING: ENSP00000274242
    RPL38ENSP000003098304STRING: ENSP00000309830
    RPL5ENSP000003593454STRING: ENSP00000359345
    RPLP0ENSP000003390274STRING: ENSP00000339027
    RPLP1ENSP000003460374STRING: ENSP00000346037
    SEC11AENSP000002682204STRING: ENSP00000268220
    SEC61BENSP000002236414STRING: ENSP00000223641
    SEC61GENSP000003415384STRING: ENSP00000341538
    SRP14ENSP000002678844STRING: ENSP00000267884
    SRP54ENSP000002167744STRING: ENSP00000216774
    UBA52ENSP000003881074STRING: ENSP00000388107
    CASC3ENSP000002646454STRING: ENSP00000264645
    DDOSTENSP000003641884STRING: ENSP00000364188
    EIF3JENSP000002618684STRING: ENSP00000261868
    EIF4A3ENSP000002693494STRING: ENSP00000269349
    EIF4BENSP000002620564STRING: ENSP00000262056
    EIF4HENSP000002657534STRING: ENSP00000265753
    EIF5ENSP000002165544STRING: ENSP00000216554
    GSPT2ENSP000003412474STRING: ENSP00000341247
    NCBP1ENSP000003642894STRING: ENSP00000364289
    NCBP2ENSP000003268064STRING: ENSP00000326806
    NKX2-2ENSP000003663474STRING: ENSP00000366347
    PPP2R1AENSP000003248044STRING: ENSP00000324804
    PPP2R2AENSP000003701134STRING: ENSP00000370113
    RNPS1ENSP000003158594STRING: ENSP00000315859
    RPN1ENSP000002962554STRING: ENSP00000296255
    RPN2ENSP000002375304STRING: ENSP00000237530
    SEC11CENSP000002997144STRING: ENSP00000299714
    SMG5ENSP000003552614STRING: ENSP00000355261
    SMG6ENSP000002630734STRING: ENSP00000263073
    SMG7ENSP000003407664STRING: ENSP00000340766
    SMG8ENSP000003009174STRING: ENSP00000300917
    SMG9ENSP000002700664STRING: ENSP00000270066
    SPCS1ENSP000002330254STRING: ENSP00000233025
    SPCS2ENSP000002636724STRING: ENSP00000263672
    SRP19ENSP000002829994STRING: ENSP00000282999
    SRP68ENSP000003120664STRING: ENSP00000312066
    SRP72ENSP000003421814STRING: ENSP00000342181
    SRPRENSP000003280234STRING: ENSP00000328023
    SSR1ENSP000002447634STRING: ENSP00000244763
    SSR2ENSP000002957024STRING: ENSP00000295702
    SSR3ENSP000002650444STRING: ENSP00000265044
    SSR4ENSP000003173314STRING: ENSP00000317331
    TRAM1ENSP000002622134STRING: ENSP00000262213
    UPF1ENSP000002628034STRING: ENSP00000262803
    UPF2ENSP000003487084STRING: ENSP00000348708
    UPF3AENSP000003644484STRING: ENSP00000364448
    UPF3BENSP000002762014STRING: ENSP00000276201
    SUMO2ENSP000004059654STRING: ENSP00000405965
    RPS9ENSP000003028964STRING: ENSP00000302896
    GNB2L1ENSP000003660134STRING: ENSP00000366013
    FAUENSP000002792594STRING: ENSP00000279259
    ABCE1ENSP000002965774STRING: ENSP00000296577
    UBBENSP000003046974STRING: ENSP00000304697
    RPS10ENSP000003472714STRING: ENSP00000347271
    RPL29ENSP000002941894STRING: ENSP00000294189
    RPL36ENSP000002525434STRING: ENSP00000252543
    RPS4Y1ENSP000002507844STRING: ENSP00000250784
    RPS4Y2ENSP000002886664STRING: ENSP00000288666
    TRMT112ENSP000003094334STRING: ENSP00000309433
    RPLP2ENSP000003224194STRING: ENSP00000322419
    FBLENSP000002218014STRING: ENSP00000221801
    EIF1ENSP000004194494STRING: ENSP00000419449
    RPL9ENSP000003460224STRING: ENSP00000346022
    RPL3LENSP000002686614STRING: ENSP00000268661
    --Q6FG913I2D: score=1 
    --ENSP000002734064STRING: ENSP00000273406
    --ENSP000002645974STRING: ENSP00000264597
    --ENSP000002336094STRING: ENSP00000233609
    --ENSP000004146644STRING: ENSP00000414664
    --ENSP000004128094STRING: ENSP00000412809
    --ENSP000004041924STRING: ENSP00000404192
    --ENSP000003952704STRING: ENSP00000395270
    --ENSP000004066354STRING: ENSP00000406635
    --ENSP000004049464STRING: ENSP00000404946
    --ENSP000004039314STRING: ENSP00000403931
    --ENSP000003978724STRING: ENSP00000397872
    --ENSP000003958864STRING: ENSP00000395886
    --ENSP000004115134STRING: ENSP00000411513
    --ENSP000003751604STRING: ENSP00000375160
    --ENSP000002369004STRING: ENSP00000236900
    --ENSP000003847184STRING: ENSP00000384718
    --ENSP000003038444STRING: ENSP00000303844
    --ENSP000004202274STRING: ENSP00000420227
    --ENSP000003971214STRING: ENSP00000397121
    --ENSP000003671664STRING: ENSP00000367166
    --ENSP000003244384STRING: ENSP00000324438
    --Q8AZK72MINT-6734067
    --ENSP000003894654STRING: ENSP00000389465
    --ENSP000003860614STRING: ENSP00000386061
    --ENSP000004125214STRING: ENSP00000412521
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000028ribosomal small subunit assembly ISS--
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006364rRNA processing IMP18697920
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--

    RPS17 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RPS17 (RS17)

    Search CenterWatch for drugs/clinical trials and news about RPS17 / RS17

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RPS17 gene: 
    NM_001021.3  

    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000330339(uc002bhr.1 uc021ssu.1) ENST00000560151 ENST00000559187
    ENST00000560826 ENST00000560977 ENST00000559636 ENST00000560084 ENST00000560652
    ENST00000559854 ENST00000560024
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    24/2925 AceView cDNA sequences (see all 2925):

    BQ684363 AA357036 AA187482 BU175826 CB109632 AA112000 BE257074 BG767794 
    BF794220 BE901795 BQ231150 BC020453 BG338952 BE294800 BE389686 BC062715 
    BQ681767 BM760276 AA303775 AJ710727 BU152848 AA583102 AA296571 BM465031 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPS17 expression in normal human tissues (normalized intensities)      RPS17 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCGCGTTC
    RPS17 Expression
    About this image


    RPS17 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Ovary (Reproductive System)
             Primary Oocyte Primary Follicle
     
     Gonad
             Primary Oocyte Primary Follicle
     
     Tonsil (Hematopoietic System)

    See RPS17 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPS17
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS17

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPS17 gene from 10/26 species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rps175 ribosomal protein S17   --   7 (45.71 cM) 81342732 
    chicken
    (Gallus gallus)
    Aves RPS176
    40S ribosomal protein S17
    98(a)
    1 → many
    10(834930-836457)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    99(a)
    possible ortholog
    GL343479.1(636199-639072)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.83372 Xenopus laevis transcribed sequence with strong similarity more 79.49(n)    CB943667.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BQ418878.12   -- 83(n)    BQ418878.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RpS171 , 3 protein biosynthesis structural
    constituent of more3
    Ribosomal protein S171
    79(a)3
    72.95(n)1
    81.15(a)1
      3 67B43
    390881  NM_079278.21  NP_524002.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rps-173 40S ribosomal protein S17 71(a)   I(6228214-6228815)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPS17B(YDR447C)4
    RPS17A1
    Ribosomal protein 51 (rp51) of the small (40s) subunit; more4
    Rps17ap1
    63.91(n)1
    69.72(a)1
      4(1355553-1354829)4
    8549841  NP_013688.11  8520584 
     NP_010735.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G052201 40S ribosomal protein S17-2 58.2(n)
    62.7(a)
      815070  NM_126548.4  NP_565320.1 
    rice
    (Oryza sativa)
    Liliopsida Os.463712 Transcribed sequence with weak similarity to protein more 71.13(n)    CB966919.1 


    ENSEMBL Gene Tree for RPS17 (if available)
    TreeFam Gene Tree for RPS17 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPS17 gene
    RPS17L1 2  
    2 SIMAP similar genes for RPS17 using alignment to 2 protein entries:     RS17_HUMAN (see all proteins):
    RPS17L    LOC392101

    RPS17 for paralogs           About GeneDecksing


    5/26 Pseudogenes.org Pseudogenes for RPS17 (see all 26)
    PGOHUM00000242480 PGOHUM00000247171 PGOHUM00000237351 PGOHUM00000244323 PGOHUM00000262142


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/12 SNPs in RPS17 are shown (see all 12)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1168408111,2
    Cpathogenic182824835(-) CAACAG/TGGTAG 2 R M mis10--------
    VAR_0344784
    ----see VAR_0344782 E K mis40--------
    rs1422623041,2
    ----82823390(+) GTGACA/GTAACT 2 Y syn10--------
    rs1476951121,2
    ----82825597(+) TCAGGC/TACCTT 1 -- us2k10--------
    rs1488102471,2
    ----82822408(+) GCAGGC/GAGATT 1 -- int10--------
    rs1168408121,2
    --pathogenic182823348(-) AGTAA-/GAGGTAT 2 Y G fra10--------
    rs1404537001,2
    ----82823466(+) ATGTGC/GATATA 1 -- int10--------
    rs1470557891,2
    ----82823632(+) CCCCCA/CACTCG 1 -- int10--------
    rs1412937301,2
    ----82826010(+) TTTTTG/TTTTTT 1 -- us2k10--------
    rs3687419661,2
    ----82824697(+) GGAAGC/TGCCGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for RPS17 (82821158 - 82824972 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for RPS17 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv33165CNV Loss17666407
    nsv510669CNV Loss20534489
    nsv483125CNV Loss15286789
    nsv428309CNV Gain18775914
    nsv833071CNV Gain17160897
    nsv904446CNV Gain21882294
    nsv471686CNV Gain+Loss15918152
    esv21531CNV Gain+Loss19812545
    nsv9285CNV Gain+Loss18304495
    esv22027CNV Gain+Loss19812545


    Human Gene Mutation Database (HGMD): RPS17

    Locus Specific Mutation Databases (LSDB): RPS17
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 180472   
    OMIM disorders: 612527  
    UniProtKB/Swiss-Prot: RS17_HUMAN, P08708
  • Diamond-Blackfan anemia 4 (DBA4) [MIM:612527]: A form of Diamond-Blackfan anemia, a congenital
    non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is
    characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of developing
    leukemia. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the
    most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • 16 diseases for RPS17:    About MalaCards
    rps17-related diamond-blackfan anemia    diamond-blackfan anemia    macrocytic anemia    pure red-cell aplasia
    reactive arthritis    hepatitis e    aplastic anemia    cleft palate
    anemia    short stature    macular degeneration    ataxia
    influenza    arthritis    leukemia    hepatitis

    1 disease from the University of Copenhagen DISEASES database for RPS17:
    Aplastic anemia

    RPS17 for disorders           About GeneDecksing

    GeneTests: RPS17
    GeneReviews: RPS17
    Genetic Association Database (GAD): RPS17
    Human Genome Epidemiology (HuGE) Navigator: RPS17 (2 documents)

    Export disorders for RPS17 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPS17 gene, integrated from 9 sources (see all 69):
    (articles sorted by number of sources associating them with RPS17)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. [Mapping the genes for ribosomal proteins S14 and S17 on human chromosomes using cDNA from a panel of hybrid cells] (PubMed id 7661859)1, 3, 9 Filipenko M.L....Mertvetsov N.P. (1995)
    2. Mutations in the ribosomal protein genes in Japanese patients with Diamond-Blackfan anemia. (PubMed id 20378560)1, 4 Konno Y....Ito E. (2010)
    3. Ribosomal protein L5 and L11 mutations are associated with cleft palate and abnormal thumbs in Diamond-Blackfan anemia patients. (PubMed id 19061985)1, 2 Gazda H.T....Beggs A.H. (2008)
    4. Ribosomal protein S17 gene (RPS17) is mutated in Diamond-Blackfan anemia. (PubMed id 17647292)1, 2 Cmejla R....Pospisilova D. (2007)
    5. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)1, 2 Zody M.C....Nusbaum C. (2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699)1, 2 Vladimirov S.N.... Otto A. (1996)
    9. The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in the human genome. (PubMed id 1577483)1, 3 Feo S....Fried M. (1992)
    10. The transcriptionally active human ribosomal protein S17 gene. (PubMed id 3240863)1, 2 Chen I.-T. and Roufa D.J. (1988)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6218 HGNC: 10397 AceView: RPS17 Ensembl:ENSG00000184779 euGenes: HUgn6218
    ECgene: RPS17 Kegg: 6218 H-InvDB: RPS17

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPS17 Pharmacogenomics, SNPs, Pathways
    Diamond-Blackfan Anemia mutation databasehttp://www.dbagenes.unito.it/home.php?select_db=RPS17

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RPS17 gene:
    Search GeneIP for patents involving RPS17

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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