RPS17 Gene
protein-coding GIFtS : 61 GCID: GC15 M082821
ribosomal protein S17
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Aliasesfor RPS17 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Ribosomal Protein S17 1 2 DBA42 5 RPS17L11 2 5 MGC720071 RPS17L21 2 5 40S Ribosomal Protein S172 S171 2 RPS17L2
Export aliases for RPS17 gene to outside databases Previous GC identifers: GC15M079008 GC15M076138 GC15M080395 GC15M080536 GC15M080608 GC15M059476
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Summariesfor RPS17 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for RPS17 : Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S17E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. (provided by RefSeq, Jul 2008) Gene Wiki entry for RPS17
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Genomic Viewsfor RPS17 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the RPS17 gene promoter:COUP-TF1 COUP HNF-4alpha2 E4BP4 HNF-4alpha1 HNF-1A S8 COUP-TF HNF-1 RSRFC4 Other transcription factors Search SABiosciences Chromatin IP Primers for RPS17 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS17
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 15q Ensembl cytogenetic band: 15q25.2 HGNC cytogenetic band: 15q RPS17 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 15 GeneLoc Exon Structure
GeneLoc location for GC15M082821: view genomic region
(about GC identifiers )
Start: 82,821,158 bp from pter End:
82,824,972 bp from pter
Size: 3,815 bases Orientation:
minus strand
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Proteinsfor RPS17 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: RS17_HUMAN, P08708 See
protein sequence )Recommended Name: Size : 135 amino acids; 15550 DaSecondary accessions : B2R4U4Explore the universe of human proteins at neXtProt for RPS17: NX_P08708 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P08708 RPS17 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_001012.1 ENSEMBL proteins: ENSP00000346045 ENSP00000453564 ENSP00000452655 ENSP00000452696 Reactome Protein details: P08708 Human Recombinant Protein Products: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
About GeneDecksing RPS17 Antibody Products: Assay Products for RPS17:
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Protein
Domains /for RPS17 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P08708 ProtoNet protein and cluster: P08708
1 Blocks protein family : IPB001210 UniProtKB/Swiss-Prot: RS17_HUMAN, P08708 Similarity : Belongs to the ribosomal protein S17e family
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Functionfor RPS17 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: Genatlas biochemistry entry for RPS17 40S ribosomal protein S17,15kDa Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: RPS17 (NM_001021 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPS17 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RPS17
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003735 structural constituent of ribosome
NAS 17647292
About GeneDecksing 4 GenomeRNAi human phenotypes for RPS17 :
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Pathways & Interactionsfor RPS17 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/6 super-pathways (see all 6 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Synthesis of PB1-F2 2 Translation initiation complex formation 3 Metabolism of mRNA 4 Disease 5 Generic Transcription Pathway
Pathway sources See GeneCards unified pathways Show all pathways 1 1 5/32 (see all 32 )1 (Kegg details for RPS17) :About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPS17 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)258 Interacting proteins for RPS17 (P08708 2 , 3 ENSP00000346045 4 via UniProtKB, MINT, STRING , and/or I2D (see top 5 )Interactant Interaction Details GeneCard External ID(s) RPS16 P62249 2 , 3 ENSP00000251453 4 MINT-8044024 I2D:
score=1 STRING: ENSP00000251453 MAP3K14 Q99558 2 , 3 MINT-48887 I2D:
score=2 RPS26 P62854 2 , 3 MINT-8044024 I2D:
score=1 RPL17 P18621 3 ENSP00000389465 4 I2D:
score=1 STRING: ENSP00000389465 RPS14 P62263 2 , 3 ENSP00000311028 4 MINT-8044024 I2D:
score=2 STRING: ENSP00000311028 RPS11 P62280 2 , 3 ENSP00000270625 4 MINT-8044024 I2D:
score=1 STRING: ENSP00000270625 RPS12 P25398 2 , 3 ENSP00000230050 4 MINT-8044024 I2D:
score=2 STRING: ENSP00000230050 RPL26 P61254 3 ENSP00000293842 4 I2D:
score=4 STRING: ENSP00000293842 RPL26L1 Q9UNX3 3 ENSP00000265100 4 I2D:
score=4 STRING: ENSP00000265100 RPL35 P42766 3 ENSP00000259469 4 I2D:
score=4 STRING: ENSP00000259469 BYSL Q13895 3 ENSP00000230340 4 I2D:
score=2 STRING: ENSP00000230340 NME1-NME2 P22392 3 I2D:
score=2 NME2 P22392 3 I2D:
score=2 NOP58 Q9Y2X3 3 ENSP00000264279 4 I2D:
score=2 STRING: ENSP00000264279 RPL34 P49207 3 ENSP00000378160 4 I2D:
score=2 STRING: ENSP00000378160 RPS24 P62847 3 ENSP00000414321 4 I2D:
score=2 STRING: ENSP00000414321 RPS3A P61247 3 ENSP00000346050 4 I2D:
score=2 STRING: ENSP00000346050 RPS4X P62701 3 ENSP00000362744 4 I2D:
score=2 STRING: ENSP00000362744 RPS8 P62241 3 ENSP00000379888 4 I2D:
score=2 STRING: ENSP00000379888 ESR2 Q92731 3 ENSP00000343925 4 I2D:
score=1 STRING: ENSP00000343925 RIOK2 Q9BVS4 3 ENSP00000283109 4 I2D:
score=1 STRING: ENSP00000283109 RPL11 P62913 3 ENSP00000363676 4 I2D:
score=1 STRING: ENSP00000363676 RPL13 P26373 3 ENSP00000307889 4 I2D:
score=1 STRING: ENSP00000307889 RPL13A P40429 3 ENSP00000375730 4 I2D:
score=1 STRING: ENSP00000375730 RPL17-C18orf32 P18621 3 I2D:
score=1 RPL27 P61353 3 ENSP00000253788 4 I2D:
score=1 STRING: ENSP00000253788 RPL27A P46776 3 ENSP00000346015 4 I2D:
score=1 STRING: ENSP00000346015 RPL3 P39023 3 ENSP00000346001 4 I2D:
score=1 STRING: ENSP00000346001 RPL30 P62888 3 ENSP00000287038 4 I2D:
score=1 STRING: ENSP00000287038 RPL6 Q02878 3 ENSP00000202773 4 I2D:
score=1 STRING: ENSP00000202773 RPS13 P62277 3 ENSP00000228140 4 I2D:
score=1 STRING: ENSP00000228140 RPS15A P62244 3 ENSP00000318646 4 I2D:
score=1 STRING: ENSP00000318646 RPS23 P62266 3 ENSP00000296674 4 I2D:
score=1 STRING: ENSP00000296674 RPS3 P23396 3 ENSP00000278572 4 I2D:
score=1 STRING: ENSP00000278572 UBE2D2 P62837 3 ENSP00000381717 4 I2D:
score=1 STRING: ENSP00000381717 ETF1 P62495 3 ENSP00000353741 4 I2D:
score=1 STRING: ENSP00000353741 RPL15 P61313 3 ENSP00000309334 4 I2D:
score=1 STRING: ENSP00000309334 RPL37A P61513 3 ENSP00000418082 4 I2D:
score=2 STRING: ENSP00000418082 UBC P0CG48 3 ENSP00000344818 4 I2D:
score=1 STRING: ENSP00000344818 RPS29 P62273 2 ENSP00000379339 4 MINT-8044024 STRING: ENSP00000379339 RPS5 P46782 3 ENSP00000196551 4 I2D:
score=1 STRING: ENSP00000196551 RPS6 P62753 3 ENSP00000369757 4 I2D:
score=4 STRING: ENSP00000369757 RPS7 P62081 3 ENSP00000339095 4 I2D:
score=1 STRING: ENSP00000339095 RPS20 P60866 2 ENSP00000009589 4 MINT-8044024 STRING: ENSP00000009589 RPS19 P39019 2 ENSP00000221975 4 MINT-8044024 STRING: ENSP00000221975 UBE2D1 P51668 3 ENSP00000363019 4 I2D:
score=1 STRING: ENSP00000363019 RPF2 Q9H7B2 3 ENSP00000402338 4 I2D:
score=1 STRING: ENSP00000402338 RPL8 P62917 3 ENSP00000262584 4 I2D:
score=2 STRING: ENSP00000262584 RPL18A Q02543 3 ENSP00000222247 4 I2D:
score=2 STRING: ENSP00000222247 RPL4 P36578 3 ENSP00000311430 4 I2D:
score=2 STRING: ENSP00000311430 RPL7A P62424 3 ENSP00000361076 4 I2D:
score=1 STRING: ENSP00000361076 RPL12 P30050 3 ENSP00000354739 4 I2D:
score=1 STRING: ENSP00000354739 RPL18 Q07020 3 ENSP00000084795 4 I2D:
score=1 STRING: ENSP00000084795 RPL35A P18077 3 ENSP00000393393 4 I2D:
score=1 STRING: ENSP00000393393 RPS21 P63220 2 ENSP00000324438 4 MINT-8044024 STRING: ENSP00000324438 RPS28 P62857 2 ENSP00000397872 4 MINT-8044024 STRING: ENSP00000397872 CLUAP1 Q96AJ1 3 I2D:
score=5 NR5A2 O00482 3 I2D:
score=5 RPL36A P83881 3 I2D:
score=3 RPS18 P62269 3 I2D:
score=3 CSNK1E P49674 3 I2D:
score=2 HEATR1 Q9H583 3 I2D:
score=2 NAT10 Q9H0A0 3 I2D:
score=2 NOB1 Q9ULX3 3 I2D:
score=2 NOC4L Q9BVI4 3 I2D:
score=2 NOL6 Q9H6R4 3 I2D:
score=2 PWP2 Q15269 3 I2D:
score=2 RPL10A P62906 3 I2D:
score=2 RPS17L P0CW22 3 I2D:
score=2 RPS27A P62979 3 I2D:
score=2 RPSA P08865 3 I2D:
score=2 TSR1 Q2NL82 3 I2D:
score=2 TTC37 Q6PGP7 3 I2D:
score=2 VCP P55072 3 I2D:
score=2 AMBRA1 Q9C0C7 3 I2D:
score=1 AP2B1 P63010 3 I2D:
score=1 APC P25054 3 I2D:
score=1 ARF1 P84077 3 I2D:
score=1 ARRB1 P49407 3 I2D:
score=1 ARRB2 P32121 3 I2D:
score=1 ATG14 Q6ZNE5 3 I2D:
score=1 ATG16L1 Q676U5 3 I2D:
score=1 BMS1 Q14692 3 I2D:
score=1 CCNH P51946 3 I2D:
score=1 CDK7 P50613 3 I2D:
score=1 CEBPZ Q03701 3 I2D:
score=1 CHN2 P52757 3 I2D:
score=1 CLN3 Q13286 3 I2D:
score=1 CNBP P62633 3 I2D:
score=1 COPG2 Q9UBF2 3 I2D:
score=1 CPSF1 Q10570 3 I2D:
score=1 CRLS1 Q9UJA2 3 I2D:
score=1 CTPS1 P17812 3 I2D:
score=1 DDA1 Q9BW61 3 I2D:
score=1 EIF2D P41214 3 I2D:
score=1 EPS15L1 Q9UBC2 3 I2D:
score=1 ESD P10768 3 I2D:
score=1 FOS P01100 3 I2D:
score=1 FOXO3 O43524 3 I2D:
score=1 GABARAP O95166 3 I2D:
score=1 GABARAPL1 Q9H0R8 3 I2D:
score=1 GNL3 Q9BVP2 3 I2D:
score=1 GRB7 Q14451 3 I2D:
score=1 GTPBP3 Q969Y2 3 I2D:
score=1 HDAC1 Q13547 3 I2D:
score=1 KBTBD7 Q8WVZ9 3 I2D:
score=1 KLHDC10 Q6PID8 3 I2D:
score=1 MAP1LC3A Q9H492 3 I2D:
score=1 MAP3K4 Q9Y6R4 3 I2D:
score=1 NAA10 P41227 3 I2D:
score=1 NSF P46459 3 I2D:
score=1 NSMAF Q92636 3 I2D:
score=1 OXA1L Q15070 3 I2D:
score=1 PDPK1 O15530 3 I2D:
score=1 PELO Q9BRX2 3 I2D:
score=1 PPA1 Q15181 3 I2D:
score=1 PPCS Q9HAB8 3 I2D:
score=1 PPP1CC P36873 3 I2D:
score=1 PRKAA1 Q13131 3 I2D:
score=1 PRKAA2 P54646 3 I2D:
score=1 PRKAB2 O43741 3 I2D:
score=1 PRKAG1 P54619 3 I2D:
score=1 PRKAG2 Q9UGJ0 3 I2D:
score=1 PRKAR1A P10644 3 I2D:
score=1 PSMD14 O00487 3 I2D:
score=1 PSMD2 Q13200 3 I2D:
score=1 PSMD4 P55036 3 I2D:
score=1 RABGAP1 Q9Y3P9 3 I2D:
score=1 RBL1 P28749 3 I2D:
score=1 RFC5 P40937 3 I2D:
score=1 RPL10 P27635 3 I2D:
score=1 RPL14 P50914 3 I2D:
score=1 RPL19 P84098 3 I2D:
score=1 RPL21 P46778 3 I2D:
score=1 RPL32 P62910 3 I2D:
score=1 RPL7 P18124 3 I2D:
score=1 RPS15 P62841 3 I2D:
score=1 SACM1L Q9NTJ5 3 I2D:
score=1 SEC31A O94979 3 I2D:
score=1 SH3GLB2 Q9NR46 3 I2D:
score=1 SLC25A3 Q00325 3 I2D:
score=1 SLC2A4 P14672 3 I2D:
score=1 TADA2A O75478 3 I2D:
score=1 TBP P20226 3 I2D:
score=1 UBA5 Q9GZZ9 3 I2D:
score=1 ULK1 O75385 3 I2D:
score=1 ULK2 Q8IYT8 3 I2D:
score=1 WIPI2 Q9Y4P8 3 I2D:
score=1 RPS25 P62851 2 MINT-8044024 EEF2 ENSP00000307940 4 STRING: ENSP00000307940 EIF2S1 ENSP00000256383 4 STRING: ENSP00000256383 EIF2S2 ENSP00000364119 4 STRING: ENSP00000364119 EIF3B ENSP00000354125 4 STRING: ENSP00000354125 EIF3D ENSP00000216190 4 STRING: ENSP00000216190 EIF3E ENSP00000220849 4 STRING: ENSP00000220849 EIF3F ENSP00000310040 4 STRING: ENSP00000310040 EIF3G ENSP00000253108 4 STRING: ENSP00000253108 EIF3H ENSP00000276682 4 STRING: ENSP00000276682 EIF3I ENSP00000362688 4 STRING: ENSP00000362688 EIF3K ENSP00000248342 4 STRING: ENSP00000248342 EIF4E ENSP00000280892 4 STRING: ENSP00000280892 EIF4G1 ENSP00000316879 4 STRING: ENSP00000316879 EIF5B ENSP00000289371 4 STRING: ENSP00000289371 INS-IGF2 ENSP00000348986 4 STRING: ENSP00000348986 RBM8A ENSP00000333001 4 STRING: ENSP00000333001 RPL22 ENSP00000346088 4 STRING: ENSP00000346088 RPL23 ENSP00000377865 4 STRING: ENSP00000377865 RPL28 ENSP00000401450 4 STRING: ENSP00000401450 RPL31 ENSP00000386717 4 STRING: ENSP00000386717 RPL37 ENSP00000274242 4 STRING: ENSP00000274242 RPL38 ENSP00000309830 4 STRING: ENSP00000309830 RPL5 ENSP00000359345 4 STRING: ENSP00000359345 RPLP0 ENSP00000339027 4 STRING: ENSP00000339027 RPLP1 ENSP00000346037 4 STRING: ENSP00000346037 SEC11A ENSP00000268220 4 STRING: ENSP00000268220 SEC61B ENSP00000223641 4 STRING: ENSP00000223641 SEC61G ENSP00000341538 4 STRING: ENSP00000341538 SRP14 ENSP00000267884 4 STRING: ENSP00000267884 SRP54 ENSP00000216774 4 STRING: ENSP00000216774 UBA52 ENSP00000388107 4 STRING: ENSP00000388107 CASC3 ENSP00000264645 4 STRING: ENSP00000264645 DDOST ENSP00000364188 4 STRING: ENSP00000364188 EIF3J ENSP00000261868 4 STRING: ENSP00000261868 EIF4A3 ENSP00000269349 4 STRING: ENSP00000269349 EIF4B ENSP00000262056 4 STRING: ENSP00000262056 EIF4H ENSP00000265753 4 STRING: ENSP00000265753 EIF5 ENSP00000216554 4 STRING: ENSP00000216554 GSPT2 ENSP00000341247 4 STRING: ENSP00000341247 NCBP1 ENSP00000364289 4 STRING: ENSP00000364289 NCBP2 ENSP00000326806 4 STRING: ENSP00000326806 NKX2-2 ENSP00000366347 4 STRING: ENSP00000366347 PPP2R1A ENSP00000324804 4 STRING: ENSP00000324804 PPP2R2A ENSP00000370113 4 STRING: ENSP00000370113 RNPS1 ENSP00000315859 4 STRING: ENSP00000315859 RPN1 ENSP00000296255 4 STRING: ENSP00000296255 RPN2 ENSP00000237530 4 STRING: ENSP00000237530 SEC11C ENSP00000299714 4 STRING: ENSP00000299714 SMG5 ENSP00000355261 4 STRING: ENSP00000355261 SMG6 ENSP00000263073 4 STRING: ENSP00000263073 SMG7 ENSP00000340766 4 STRING: ENSP00000340766 SMG8 ENSP00000300917 4 STRING: ENSP00000300917 SMG9 ENSP00000270066 4 STRING: ENSP00000270066 SPCS1 ENSP00000233025 4 STRING: ENSP00000233025 SPCS2 ENSP00000263672 4 STRING: ENSP00000263672 SRP19 ENSP00000282999 4 STRING: ENSP00000282999 SRP68 ENSP00000312066 4 STRING: ENSP00000312066 SRP72 ENSP00000342181 4 STRING: ENSP00000342181 SRPR ENSP00000328023 4 STRING: ENSP00000328023 SSR1 ENSP00000244763 4 STRING: ENSP00000244763 SSR2 ENSP00000295702 4 STRING: ENSP00000295702 SSR3 ENSP00000265044 4 STRING: ENSP00000265044 SSR4 ENSP00000317331 4 STRING: ENSP00000317331 TRAM1 ENSP00000262213 4 STRING: ENSP00000262213 UPF1 ENSP00000262803 4 STRING: ENSP00000262803 UPF2 ENSP00000348708 4 STRING: ENSP00000348708 UPF3A ENSP00000364448 4 STRING: ENSP00000364448 UPF3B ENSP00000276201 4 STRING: ENSP00000276201 SUMO2 ENSP00000405965 4 STRING: ENSP00000405965 RPS9 ENSP00000302896 4 STRING: ENSP00000302896 GNB2L1 ENSP00000366013 4 STRING: ENSP00000366013 FAU ENSP00000279259 4 STRING: ENSP00000279259 ABCE1 ENSP00000296577 4 STRING: ENSP00000296577 UBB ENSP00000304697 4 STRING: ENSP00000304697 RPS10 ENSP00000347271 4 STRING: ENSP00000347271 RPL29 ENSP00000294189 4 STRING: ENSP00000294189 RPL36 ENSP00000252543 4 STRING: ENSP00000252543 RPS4Y1 ENSP00000250784 4 STRING: ENSP00000250784 RPS4Y2 ENSP00000288666 4 STRING: ENSP00000288666 TRMT112 ENSP00000309433 4 STRING: ENSP00000309433 RPLP2 ENSP00000322419 4 STRING: ENSP00000322419 FBL ENSP00000221801 4 STRING: ENSP00000221801 EIF1 ENSP00000419449 4 STRING: ENSP00000419449 RPL9 ENSP00000346022 4 STRING: ENSP00000346022 RPS4XP21 ENSP00000420227 4 STRING: ENSP00000420227 RPL3L ENSP00000268661 4 STRING: ENSP00000268661 -- Q6FG91 3 I2D:
score=1 -- ENSP00000273406 4 STRING: ENSP00000273406 -- ENSP00000264597 4 STRING: ENSP00000264597 -- ENSP00000233609 4 STRING: ENSP00000233609 -- ENSP00000414664 4 STRING: ENSP00000414664 -- ENSP00000412809 4 STRING: ENSP00000412809 -- ENSP00000404192 4 STRING: ENSP00000404192 -- ENSP00000395270 4 STRING: ENSP00000395270 -- ENSP00000406635 4 STRING: ENSP00000406635 -- ENSP00000404946 4 STRING: ENSP00000404946 -- ENSP00000403931 4 STRING: ENSP00000403931 -- ENSP00000395886 4 STRING: ENSP00000395886 -- ENSP00000411513 4 STRING: ENSP00000411513 -- ENSP00000375160 4 STRING: ENSP00000375160 -- ENSP00000236900 4 STRING: ENSP00000236900 -- ENSP00000384718 4 STRING: ENSP00000384718 -- ENSP00000303844 4 STRING: ENSP00000303844 -- ENSP00000397121 4 STRING: ENSP00000397121 -- ENSP00000367166 4 STRING: ENSP00000367166 -- Q8AZK7 2 MINT-6734067 -- ENSP00000386061 4 STRING: ENSP00000386061 -- ENSP00000412521 4 STRING: ENSP00000412521 -- ENSP00000411236 4 STRING: ENSP00000411236
About this table Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17 ): About this table
About GeneDecksing
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Drugs & Compoundsfor RPS17 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for RPS17 RPS17 / RS17
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Transcriptsfor RPS17 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for RPS17 gene: NM_001021.3 10 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000330339 (uc002bhr.1 uc021ssu.1 ) ENST00000560151 ENST00000559187 ENST00000560826 ENST00000560977 ENST00000559636 ENST00000560084 ENST00000560652 ENST00000559854 ENST00000560024 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: RPS17 (NM_001021 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPS17 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RPS17
24/2925 AceView cDNA sequences (see all 2925 ):
BF475644 BM841150 BG824782 BE391134 BQ678752 F27701 BQ675511 BE277421 BQ954838 BQ130567 AW512342 BM760477 BQ942781 AA135090 AA852123 BG472362 BE295330 BU175479 BM051340 BG818710 BM512300 BM772297 BQ949090 BE256535 GeneLoc Exon Structure
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Expression for RPS17 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section RPS17 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GGCCGCGTTC
About this image RPS17 expression in embryonic tissues and stem cells About this table 1 LifeMap In Vivo Development Anatomical Compartment/CellTissue Category (developmental path) Ovary Primary Follicle Primary Oocyte Female Gametocytes, Germ Cells Expression: Experimental details:
In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell Name Category Endoderm-like cells (Generation of hepato... )
See RPS17 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for RPS17 SABiosciences Custom PCR Arrays for RPS17 Primer Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat
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Orthologsfor RPS17 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for RPS17 gene from 9/37 species (see all 37 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves --
Uncharacterized protein
85(a)
1 → many
10(707000-709787)
lizard Reptilia --
--
99(a)
1 → many
GL343479.1(636199-639072)
African clawed frog Amphibia Xl.83372
Xenopus laevis transcribed sequence with strong similarity more
79.49(n)
CB943667.1
zebrafish Actinopterygii BQ418878.12
--
83(n)
BQ418878.1
fruit fly Insecta RpS171 3
protein biosynthesis structural constituentmore 3 1
79(a) 3 72.95(n) 1 81.15(a) 1
3 67B43 39088 1 NM_079278.2 1 NP_524002.1 1
worm Secernentea rps-173
40S ribosomal protein S17
71(a)
I(6228214-6228815) --
baker's yeast Saccharomycetes RPS17B(YDR447C)4 1
Ribosomal protein 51 (rp51) of the small (40s) subunit; more 4 1
63.91(n) 1 69.72(a) 1
4(1355553-1354829) 4 854984 1 NP_013688.1 1 852058 4 NP_010735.1 4
thale cress eudicotyledons AT2G052201
40S ribosomal protein S17-2
58.2(n) 62.7(a)
815070 NM_126548.4 NP_565320.1
rice Liliopsida Os.463712
Transcribed sequence with weak similarity to protein more
71.13(n)
CB966919.1
ENSEMBL Gene Tree for RPS17 (if available)TreeFam Gene Tree for RPS17 (if available)
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Paralogsfor RPS17 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for RPS17 gene RPS17L 1 2 2 SIMAP similar genes for RPS17 using alignment to 2 protein entries: RS17_HUMAN (see all proteins ):RPS17L LOC392101 About GeneDecksing 5/26 Pseudogenes.org Pseudogenes for RPS17 (see all 26 )PGOHUM00000242480 PGOHUM00000247171 PGOHUM00000237351 PGOHUM00000244323 PGOHUM00000262142
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Genomic Variantsfor RPS17 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 15 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for RPS17 (82821158 - 82824972 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 8 variations for RPS17 8 CNVs 0190 30716 3972 72314 72323 2197 7074 0788 Human Gene Mutation Database (HGMD) : RPS17 Locus Specific Mutation Databases (LSDB): RPS17 SABiosciences Cancer Mutation PCR Assays
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Disorders
/ Diseasesfor RPS17 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 180472 OMIM disorders : 612527 UniProtKB/Swiss-Prot: RS17_HUMAN, P08708 Defects in RPS17 are the cause of Diamond-Blackfan anemia type 4 (DBA4) [MIM:612527]. DBA4 is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies 13 : About MalaCards diamond-blackfan anemia macrocytic anemia short stature cleft palate reactive arthritis aplastic anemia macular degeneration anemia arthritis ataxia malaria leukemia carcinoma 2 diseases from the University of Copenhagen DISEASES database for RPS17 :Diamond-Blackfan anemia Pure red-cell aplasia GeneTests: RPS17 Diamond-Blackfan Anemia Human Genome Epidemiology (HuGE) Navigator: RPS17 (2 documents) Export disorders for RPS17 gene to outside databases
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Publicationsfor RPS17 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for RPS17 gene, integrated from 9 sources (see all 54 ):(articles sorted by number of sources associating them with RPS17) Utopia : connect your pdf to the dynamic
[Mapping the genes for ribosomal proteins S14 and S17 on human chromosomes using cDNA from a panel of hybrid cells] (PubMed id 7661859) 1 , 3, 9(1995) Ribosomal protein L5 and L11 mutations are associated with cleft palate and abnormal thumbs in Diamond-Blackfan anemia patients. (PubMed id 19061985) 1 , 2 (2008) Ribosomal protein S17 gene (RPS17) is mutated in Diamond-Blackfan anemia. (PubMed id 17647292) 1 , 2 (2007) Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171) 1 , 2 (2006) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 (2004) Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699) 1 , 2 (1996) The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in the human genome. (PubMed id 1577483) 1 , 3(1992) The transcriptionally active human ribosomal protein S17 gene. (PubMed id 3240863) 1 , 2 (1988) Homologous ribosomal proteins in bacteria, yeast, and humans. (PubMed id 3529092) 1 , 2 (1986)
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External Searches for RPS17 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing RPS17 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing RPS17 gene
(According to HUGE )
About This Section --
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Specialized Databases showing RPS17 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for RPS17 Pharmacogenomics, SNPs, Pathways Diamond-Blackfan Anemia mutation database http://www.dbagenes.unito.it/home.php?select_db=RPS17
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About This Section Patent Information for RPS17 gene: RPS17 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor RPS17 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
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Browse OriGene Antibodies OriGene shRNA RFP for RPS17 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for RPS17 OriGene 3'-UTR Clone for RPS17 OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RPS17 Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPS17 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS17 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
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Kegg Pathway 
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Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Negative
Selective marker
Curated
In-situ hybridization
