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RPS17 Gene

protein-coding GIFtS: 60

GC15M080608

ribosomal protein S17
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DBA4 ^², ⁵
MGC72007 ^¹, ²
RPS17L1 ^¹, ², ⁵
RPS17L2 ^¹, ², ⁵

Descriptions
40S ribosomal protein S17 ^²
ribosomal protein S17 ^²

External Ids
HGNC: 10397¹
Entrez Gene: 6218²
UniProtKB: P08708³
Ensembl: ENSG00000184779⁷

Search outside databases for aliases for RPS17 gene

Previous GC identifers: GC15M079008 GC15M076138 GC15M080395 GC15M080536

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for RPS17:

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a

large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80

structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the

40S subunit. The protein belongs to the S17E family of ribosomal proteins. It is located in the

cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed

pseudogenes of this gene dispersed through the genome. [provided by RefSeq]

Gene Wiki entry for RPS17

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the RPS17 gene

Entrez Gene cytogenetic band: 15q Ensembl cytogenetic band: 15q25.2 HGNC cytogenetic band: 15q

RPS17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M080608: (about GC identifiers)

Start:	80,608,216 bp from pter
End:	80,611,920 bp from pter
Size:	3,705 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000015.8 NT_010194.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: RS17_HUMAN, P08708 (See protein sequence)

Recommended Name: 40S ribosomal protein S17

Size: 135 amino acids; 15550 Da

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001012.1

ENSEMBL proteins:

ENSP00000346045

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (RPS17)
	Human Recombinant Proteins from Abnova (RPS17)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005829	cytosol	EXP	12588972
GO:0005840	ribosome	NAS	3240863
GO:0022627	cytosolic small ribosomal subunit	IDA	8706699 15883184

About this table

Antibodies for RPS17:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for RPS17
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (RPS17), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (RPS17)
	Novus Biologicals Antibodies for RPS17

Assays for RPS17:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P08708

ProtoNet protein and cluster: P08708

1 Blocks protein family: IPB001210 Ribosomal protein S17e

UniProtKB/Swiss-Prot: RS17_HUMAN, P08708

Similarity: Belongs to the ribosomal protein S17e family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RPS17)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001021

Applied Biosystems Silencer® siRNAs for RPS17

Sigma-Aldrich siRNA for RPS17

Sigma-Aldrich shRNA for RPS17

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for RPS17
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001021
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001021
untagged cDNA clones in CMV expression vector (see all 2): AK097136

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: AK097136

Genatlas biochemistry entry for RPS17:

40S ribosomal protein S17,15kDa

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003735	structural constituent of ribosome	NAS	17647292 18412286

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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4 Interacting proteins for RPS17 (P08708² ENSP00000346045³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAP3K14	Q99558²	MINT-48887
RPS11P5	ENSP00000270625³	STRING (score=.726)
RPS24	ENSP00000361435³	STRING (score=.716)
--	Q8AZK7²	MINT-6734067

About this table

5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006364	rRNA processing	IMP	18697920
GO:0006413	translational initiation	NAS	17647292
GO:0006414	translational elongation	EXP	15189156
GO:0034101	erythrocyte homeostasis	IMP	17647292
GO:0042274	ribosomal small subunit biogenesis	IMP	18697920

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for RPS17

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RPS17)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001021

Sigma-Aldrich siRNA for RPS17

Sigma-Aldrich shRNA for RPS17

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001021

REFSEQ mRNAs for RPS17 gene:

NM_001021.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001021

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001021
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001021
                                 untagged cDNA clones in CMV expression vector (see all 2): AK097136

Additional cDNA sequence:

AK311951.1 BC009407.2 BC019899.1 BC020453.1 BC022370.1 BC049824.1 BC062715.1 BC070222.1

BC071928.1 CR595559.1 CR602312.1 CR609691.1 CR612555.1 CR615408.1 CR616208.1 CR618328.1

CR618357.1 CR620738.1 M13932.1

24/69 DOTS entries (see all 69 ):

DT.95231387 DT.95378808 DT.98081977 DT.92469637 DT.100060125 DT.100638918 DT.100739925 DT.92469644

DT.92469626 DT.92469622 DT.121021573 DT.100739953 DT.100739938 DT.121021874 DT.100739968 DT.91869254

DT.100876268 DT.91651851 DT.100868623 DT.95252543 DT.121022024 DT.100739912 DT.121021789 DT.100739963

24/2925 AceView cDNA sequences (see all 2925 ):

BQ961732 BE277510 BQ689486 AA100259 BE259635 AW327844 AW197160 BM841531

BQ682440 BE018962 BU845076 BE407190 AI424764 BG291467 AA371531 BQ949434

BM918016 AI818016 CR618357 BQ959691 BG164256 BG754205 BG770424 BM551200

highest scoring ESTs for RPS17:

BG766552 M13932 AA071281 AA094178 AA094742 AA095622 AA147118 AA186422 AA225295 AA228991

Unigene Cluster for RPS17:

Ribosomal protein S17

Hs.433427 [show with all ESTs]

Unigene Representative Sequence: BM918752

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000330339

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

RPS17 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for RPS17

¹ / ² / ³

8 probe-sets matching RPS17 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34593_g_at²^{, 3}	U95-A	6	1.00	0.31	0.99	1.00	M13932	1.00	0.77	0.89	1
34592_at²^{, 3}	U95-A	7	1.00	0.28	0.99	1.00	M13932	1.00	0.77	0.89	1
201665_x_at²^{, 3}	U133-A	8	1.00	0.37	--	--	NM_001021	0.60	0.83	0.73	1
212578_x_at²^{, 3}	U133-A	8	0.91	0.35	--	--	BF026595	0.20	0.50	0.38	1
211487_x_at²	U133-A	24	0.91	0.29	--	--	--	--	--	--	--
201665_x_at²	U133Plus2	8	1.00	0.37	--	--	--	--	--	--	--
212578_x_at²	U133Plus2	8	0.91	0.35	--	--	--	--	--	--	--
211487_x_at²	U133Plus2	24	0.91	0.29	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGCCGCGTTC

SOURCE GeneReport for Unigene cluster: Hs.433427
Expression variation in blood from EXPOLDB for RPS17

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for RPS17 gene from 5/16 species (see all 16 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	RPS17¹	--	Ribosomal protein S17	89.14(n) 99.26(a)	403681 NM_001003099.1 NP_001003099.1
cow (Bos taurus)	RPS17¹	--	ribosomal protein S17	90.86(n) 99.26(a)	788861 XM_001255782.1 XP_001255783.1
rat (Rattus norvegicus)	RGD1559955¹	--	similar to 40S ribosomal protein S17	88.89(n) 93.33(a)	367324 XM_346081.3 XP_346082.3
mouse (Mus musculus)	Rps17⁵ OTTMUSG00000005228¹	7⁵	ribosomal protein S17⁵ predicted gene, OTTMUSG00000005228¹	88.38(n)¹ 96.97(a)¹	382492¹ XM_980426.2¹ XP_985520.2¹ AK007992⁵ AK010647⁵ (see all 16)
chicken (Gallus gallus)	RPS17¹	--	ribosomal protein S17	84.46(n) 100(a)	374053 NM_204217.1 NP_989548.1

About this table Species with no ortholog for RPS17

ENSEMBL Gene Tree for RPS17

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for RPS17 gene

ENSG00000182774² RPS17P2² RPS17P5²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 180472 disorders: 612527

UniProtKB/Swiss-Prot: RS17_HUMAN, P08708

Defects in RPS17 are the cause of Diamond-Blackfan anemia type 4 (DBA4) [MIM:612527]. DBA4

is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that

usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to

severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of

Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most

frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital

anomalies

Human Gene Mutation Database: RPS17

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/27 PubMed articles for RPS17 gene (see all 27 ):

[Mapping the genes for ribosomal proteins S14 and S17 on human chromosomes using cDNA from a panel of hybrid cells] (PubMed id 7661859)^{1, 2, 3} Filipenko M.L....Mertvetsov N.P. (1995)
Ribosomal protein L5 and L11 mutations are associated with cleft palate and abnormal thumbs in Diamond-Blackfan anemia patients. (PubMed id 19061985)^{3, 4} Gazda H.T....Beggs A.H. (2008)
Ribosomal protein S17 gene (RPS17) is mutated in Diamond-Blackfan anemia. (PubMed id 17647292)^{3, 4} Cmejla R....Pospisilova D. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699)^{3, 4} Vladimirov S.N.... Otto A. (1996)
The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in the human genome. (PubMed id 1577483)^{2, 3} Feo S....Fried M. (1992)
The transcriptionally active human ribosomal protein S17 gene. (PubMed id 3240863)^{3, 4} Chen I.T. and Roufa D.J. (1988)
Homologous ribosomal proteins in bacteria, yeast, and humans. (PubMed id 3529092)^{3, 4} Chen I.-T.... Roufa D.J. (1986)
Rapamycin-sensitive phosphorylation of ribosomal protein S17 by p70 S6 kinase. (PubMed id 8878544)^{1, 3} Patel H.R....Gelfand E.W. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6218	HGNC: 10397	AceView: RPS17	Ensembl:ENSG00000184779	euGenes: HUgn6218
ECgene: RPS17	H-InvDB: RPS17

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
Diamond-Blackfan Anemia mutation database	http://www.dbagenes.unito.it/home.php?select_db=RPS17

Licensable Technologies for RPS17
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for RPS17:

TaqMan ® Gene Expression Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for RPS17-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for RPS17		Antibodies for RPS17
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for RPS17		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (RPS17)
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	Custom Service for Rabbit Pab from Full-length Protein

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	Antibodies (RPS17)

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Search Tocris compounds for RPS17

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for RPS17

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RPS17 Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for RPS17

Summaries
for RPS17

Genomic Location
for RPS17

Proteins
for RPS17

Protein Domains/
Families
for RPS17

Gene Function
for RPS17

Pathways & Interactions
for RPS17

Drugs & Compounds
for RPS17

Transcripts
for RPS17

Expression
for RPS17

Orthologs
for RPS17

Paralogs
for RPS17

SNPs/Variants
for RPS17

Disorders & Mutations
for RPS17

Medical News
for RPS17

Publications
for RPS17

Search for RPS17

Genome Databases showing RPS17

Other Databases showing RPS17

Specialized Databases showing RPS17

Licensable Technologies
for RPS17

Services
for RPS17

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

RPS17 Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor RPS17

Summariesfor RPS17

Genomic Locationfor RPS17

Proteinsfor RPS17

Protein Domains/Familiesfor RPS17

Gene Functionfor RPS17

Pathways & Interactionsfor RPS17

Drugs & Compoundsfor RPS17

Transcriptsfor RPS17

Expression for RPS17

Orthologsfor RPS17

Paralogsfor RPS17

SNPs/Variantsfor RPS17

Disorders & Mutationsfor RPS17

Medical Newsfor RPS17

Publicationsfor RPS17

Search for RPS17

Genome Databases showing RPS17

Other Databases showing RPS17

Specialized Databases showing RPS17

Licensable Technologiesfor RPS17

Servicesfor RPS17

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for RPS17

Summaries
for RPS17

Genomic Location
for RPS17

Proteins
for RPS17

Protein Domains/
Families
for RPS17

Gene Function
for RPS17

Pathways & Interactions
for RPS17

Drugs & Compounds
for RPS17

Transcripts
for RPS17

Expression
for RPS17

Orthologs
for RPS17

Paralogs
for RPS17

SNPs/Variants
for RPS17

Disorders & Mutations
for RPS17

Medical News
for RPS17

Publications
for RPS17

Licensable Technologies
for RPS17

Services
for RPS17