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Aliases for RPS17 Gene

Aliases for RPS17 Gene

  • Ribosomal Protein S17 2 3
  • RPS17L1 3 6
  • RPS17L2 3 6
  • DBA4 3 6
  • Ribosomal Protein S17-Like 2
  • 40S Ribosomal Protein S17 3
  • RPS17L 3
  • S17 3

External Ids for RPS17 Gene

Previous Symbols for RPS17 Gene

  • RPS17L

Summaries for RPS17 Gene

Entrez Gene Summary for RPS17 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S17E family of ribosomal proteins and is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia 4. Alternative splicing of this gene results in multiple transcript variants. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Apr 2014]

GeneCards Summary for RPS17 Gene

RPS17 (Ribosomal Protein S17) is a Protein Coding gene. Diseases associated with RPS17 include diamond-blackfan anemia 4 and rps17-related diamond-blackfan anemia. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for RPS17 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS17 Gene

Genomics for RPS17 Gene

Genomic Location for RPS17 Gene

Start:
82,536,753 bp from pter
End:
82,540,564 bp from pter
Size:
3,812 bases
Orientation:
Minus strand

Genomic View for RPS17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPS17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS17 Gene

Regulatory Elements for RPS17 Gene

Proteins for RPS17 Gene

  • Protein details for RPS17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08708-RS17_HUMAN
    Recommended name:
    40S ribosomal protein S17
    Protein Accession:
    P08708
    Secondary Accessions:
    • B2R4U4

    Protein attributes for RPS17 Gene

    Size:
    135 amino acids
    Molecular mass:
    15550 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS17 Gene

neXtProt entry for RPS17 Gene

Proteomics data for RPS17 Gene at MOPED

Post-translational modifications for RPS17 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys19, Lys49, Lys59, Lys72, Lys107, and Lys129

Other Protein References for RPS17 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RPS17 Gene

Domains for RPS17 Gene

Gene Families for RPS17 Gene

HGNC:
  • RPS :S ribosomal proteins

Protein Domains for RPS17 Gene

UniProtKB/Swiss-Prot:

RS17_HUMAN
Family:
  • Belongs to the ribosomal protein S17e family.:
    • P08708
genes like me logo Genes that share domains with RPS17: view

Function for RPS17 Gene

Molecular function for RPS17 Gene

GENATLAS Biochemistry: 40S ribosomal protein S17,15kDa

Gene Ontology (GO) - Molecular Function for RPS17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 17647292
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with RPS17: view
genes like me logo Genes that share phenotypes with RPS17: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPS17 Gene

Localization for RPS17 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS17 Gene COMPARTMENTS Subcellular localization image for RPS17 gene
Compartment Confidence
cytosol 5
nucleus 1

Gene Ontology (GO) - Cellular Components for RPS17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
GO:0005840 ribosome NAS 3240863
GO:0005925 focal adhesion IDA 21423176
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with RPS17: view

Pathways for RPS17 Gene

SuperPathways for RPS17 Gene

Superpath Contained pathways
1 Influenza Viral RNA Transcription and Replication
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 CFTR translational fidelity (class I mutations)
.54
4 Disease
5 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
genes like me logo Genes that share pathways with RPS17: view

Pathways by source for RPS17 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for RPS17 Gene
1 BioSystems pathway for RPS17 Gene

Gene Ontology (GO) - Biological Process for RPS17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000028 ribosomal small subunit assembly IBA --
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing IMP 18697920
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPS17: view

Transcripts for RPS17 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for RPS17 Gene

No ASD Table

Relevant External Links for RPS17 Gene

GeneLoc Exon Structure for
RPS17
ECgene alternative splicing isoforms for
RPS17

Expression for RPS17 Gene

mRNA expression in normal human tissues for RPS17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RPS17 Gene

genes like me logo Genes that share expressions with RPS17: view

Orthologs for RPS17 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 100 (a)
OneToMany
RPS17 36
  • 96.54 (n)
  • 96.3 (a)
cow
(Bos Taurus)
Mammalia RPS17 36
  • 90.62 (n)
  • 98.52 (a)
RPS17 37
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 91 (a)
OneToMany
RPS17 36
  • 89.14 (n)
  • 99.26 (a)
mouse
(Mus musculus)
Mammalia Rps17 36
  • 89.14 (n)
  • 99.26 (a)
Rps17 16
Rps17 37
  • 99 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 96 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 99 (a)
OneToMany
chicken
(Gallus gallus)
Aves RPS17 37
  • 98 (a)
OneToMany
RPS17L 36
  • 83.95 (n)
  • 98.52 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 99 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.8337 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rps17 36
  • 83.21 (n)
  • 99.26 (a)
Str.6800 36
zebrafish
(Danio rerio)
Actinopterygii RPS17L 37
  • 98 (a)
OneToMany
zgc:114188 36
  • 82.96 (n)
  • 98.5 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpS17 37
  • 77 (a)
OneToMany
RpS17 38
  • 79 (a)
worm
(Caenorhabditis elegans)
Secernentea rps-17 36
  • 69.49 (n)
  • 73.73 (a)
rps-17 37
  • 69 (a)
OneToMany
rps-17 38
  • 71 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER319W 36
  • 65.75 (n)
  • 69.72 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS17A 36
  • 63.61 (n)
  • 69.72 (a)
RPS17A 37
  • 57 (a)
ManyToMany
RPS17B 37
  • 57 (a)
ManyToMany
RPS17B 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B01474g 36
  • 66.06 (n)
  • 69.72 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G05220 36
  • 58.2 (n)
  • 62.7 (a)
rice
(Oryza sativa)
Liliopsida Os.46371 36
Os03g0109500 36
  • 61.16 (n)
  • 64.46 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.22649 36
bread mold
(Neurospora crassa)
Ascomycetes NCU07014 36
  • 69.59 (n)
  • 74.56 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps1701 36
  • 62.87 (n)
  • 71.05 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14632 36
Species with no ortholog for RPS17:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPS17 Gene

ENSEMBL:
Gene Tree for RPS17 (if available)
TreeFam:
Gene Tree for RPS17 (if available)

Paralogs for RPS17 Gene

Selected SIMAP similar genes for RPS17 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RPS17: view

No data available for Paralogs for RPS17 Gene

Variants for RPS17 Gene

Sequence variations from dbSNP and Humsavar for RPS17 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
VAR_034478 -

Structural Variations from Database of Genomic Variants (DGV) for RPS17 Gene

Variant ID Type Subtype PubMed ID
nsv904446 CNV Gain 21882294
nsv510669 CNV Loss 20534489
esv33165 CNV Loss 17666407
esv21531 CNV Gain+Loss 19812545
nsv9285 CNV Gain+Loss 18304495
nsv428309 CNV Gain 18775914
dgv763e1 CNV Complex 17122850
dgv764e1 CNV Complex 17122850
nsv469699 CNV Complex 16826518
nsv471686 CNV Gain+Loss 15918152
esv22027 CNV Gain+Loss 19812545
nsv483125 CNV Loss 15286789
nsv833071 CNV Gain 17160897

Relevant External Links for RPS17 Gene

HapMap Linkage Disequilibrium report
RPS17
Human Gene Mutation Database (HGMD)
RPS17
Locus Specific Mutation Databases (LSDB)
RPS17

Disorders for RPS17 Gene

(1) OMIM Diseases for RPS17 Gene (180472)

UniProtKB/Swiss-Prot

RS17_HUMAN
  • Diamond-Blackfan anemia 4 (DBA4) [MIM:612527]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of developing leukemia. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. {ECO:0000269 PubMed:17647292, ECO:0000269 PubMed:19061985}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for RPS17 Gene

Relevant External Links for RPS17

GeneTests
RPS17
GeneReviews
RPS17
Genetic Association Database (GAD)
RPS17
Human Genome Epidemiology (HuGE) Navigator
RPS17
genes like me logo Genes that share disorders with RPS17: view

Publications for RPS17 Gene

  1. [Mapping the genes for ribosomal proteins S14 and S17 on human chromosomes using cDNA from a panel of hybrid cells]. (PMID: 7661859) Filipenko M.L. … Mertvetsov N.P. (Bioorg. Khim. 1995) 2 3 23
  2. The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in the human genome. (PMID: 1577483) Feo S. … Fried M. (Genomics 1992) 2 3
  3. The transcriptionally active human ribosomal protein S17 gene. (PMID: 3240863) Chen I.-T. … Roufa D.J. (Gene 1988) 3 4
  4. Homologous ribosomal proteins in bacteria, yeast, and humans. (PMID: 3529092) Chen I.-T. … Roufa D.J. (Proc. Natl. Acad. Sci. U.S.A. 1986) 3 4
  5. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PMID: 8706699) Vladimirov S.N. … Otto A. (Eur. J. Biochem. 1996) 3 4

Products for RPS17 Gene

Sources for RPS17 Gene

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