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Aliases for RPS16 Gene

Aliases for RPS16 Gene

  • Ribosomal Protein S16 2 3
  • 40S Ribosomal Protein S16 2 3
  • S16 3

External Ids for RPS16 Gene

Summaries for RPS16 Gene

Entrez Gene Summary for RPS16 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S9P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS16 Gene

RPS16 (Ribosomal Protein S16) is a Protein Coding gene. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPS16 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS16 Gene

Genomics for RPS16 Gene

Genomic Location for RPS16 Gene

Start:
39,433,207 bp from pter
End:
39,436,020 bp from pter
Size:
2,814 bases
Orientation:
Minus strand

Genomic View for RPS16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPS16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS16 Gene

Regulatory Elements for RPS16 Gene

Proteins for RPS16 Gene

  • Protein details for RPS16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62249-RS16_HUMAN
    Recommended name:
    40S ribosomal protein S16
    Protein Accession:
    P62249
    Secondary Accessions:
    • B2RDD5
    • P17008

    Protein attributes for RPS16 Gene

    Size:
    146 amino acids
    Molecular mass:
    16445 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS16 Gene

neXtProt entry for RPS16 Gene

Proteomics data for RPS16 Gene at MOPED

Post-translational modifications for RPS16 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys4, Lys33, Lys50, Lys60, Lys73, Lys90, Lys98, and Lys109

Other Protein References for RPS16 Gene

No data available for DME Specific Peptides for RPS16 Gene

Domains for RPS16 Gene

Gene Families for RPS16 Gene

HGNC:
  • RPS :S ribosomal proteins

UniProtKB/Swiss-Prot:

RS16_HUMAN
Family:
  • Belongs to the ribosomal protein S9P family.:
    • P62249
genes like me logo Genes that share domains with RPS16: view

Function for RPS16 Gene

Molecular function for RPS16 Gene

GENATLAS Biochemistry: 40S ribosomal protein S16,16kDa

Gene Ontology (GO) - Molecular Function for RPS16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 17881366
GO:0003735 structural constituent of ribosome IEA --
GO:0005515 protein binding IPI 24725412
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with RPS16: view
genes like me logo Genes that share phenotypes with RPS16: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPS16 Gene

Localization for RPS16 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS16 Gene COMPARTMENTS Subcellular localization image for RPS16 gene
Compartment Confidence
cytosol 5
chloroplast 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPS16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005840 ribosome --
GO:0005925 focal adhesion IDA 21423176
GO:0015935 small ribosomal subunit IDA 15883184
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with RPS16: view

Pathways for RPS16 Gene

SuperPathways for RPS16 Gene

Superpath Contained pathways
1 Influenza Viral RNA Transcription and Replication
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 CFTR translational fidelity (class I mutations)
.54
4 Disease
5 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
genes like me logo Genes that share pathways with RPS16: view

Pathways by source for RPS16 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for RPS16 Gene
1 BioSystems pathway for RPS16 Gene

Gene Ontology (GO) - Biological Process for RPS16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing IMP 18697920
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
genes like me logo Genes that share ontologies with RPS16: view

Transcripts for RPS16 Gene

Unigene Clusters for RPS16 Gene

Ribosomal protein S16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPS16 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: - -
SP6: - -
SP7: -
SP8:

Relevant External Links for RPS16 Gene

GeneLoc Exon Structure for
RPS16
ECgene alternative splicing isoforms for
RPS16

Expression for RPS16 Gene

mRNA expression in normal human tissues for RPS16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS16 Gene

SOURCE GeneReport for Unigene cluster for RPS16 Gene Hs.397609

genes like me logo Genes that share expressions with RPS16: view

Orthologs for RPS16 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPS16 36
  • 99.32 (n)
  • 100 (a)
RPS16 37
  • 60 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RPS16 36
  • 91.1 (n)
  • 100 (a)
RPS16 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPS16 36
  • 90.18 (n)
  • 100 (a)
RPS16 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rps16 36
  • 89.5 (n)
  • 100 (a)
Rps16 16
Rps16 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RPS16 37
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPS16 37
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rps16 36
  • 89.04 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves RPS16 36
  • 79.91 (n)
  • 98.63 (a)
RPS16 37
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPS16 37
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rps16 36
  • 79 (n)
  • 96.58 (a)
Str.1030 36
zebrafish
(Danio rerio)
Actinopterygii rps16 36
  • 82.65 (n)
  • 96.58 (a)
rps16 37
  • 96 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011424 36
  • 74.36 (n)
  • 81.82 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpS16 36
  • 78.49 (n)
  • 88.65 (a)
RpS16 37
  • 84 (a)
OneToOne
CG4046 38
  • 88 (a)
worm
(Caenorhabditis elegans)
Secernentea rps-16 36
  • 71.43 (n)
  • 77.14 (a)
rps-16 37
  • 74 (a)
OneToOne
rps-16 38
  • 77 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR258W 36
  • 61.35 (n)
  • 65.94 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS16A 36
  • 57.97 (n)
  • 65.94 (a)
RPS16A 37
  • 63 (a)
OneToMany
RPS16B 37
  • 63 (a)
OneToMany
RPS16B 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E21979g 36
  • 57.25 (n)
  • 64.49 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G18380 36
  • 68.26 (n)
  • 73.97 (a)
rice
(Oryza sativa)
Liliopsida Os11g0127900 36
  • 66.2 (n)
  • 69.44 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08620 36
  • 66.67 (n)
  • 69.06 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps1601 36
  • 65 (n)
  • 72.14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 76 (a)
OneToOne
Species with no ortholog for RPS16:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS16 Gene

ENSEMBL:
Gene Tree for RPS16 (if available)
TreeFam:
Gene Tree for RPS16 (if available)

Paralogs for RPS16 Gene

genes like me logo Genes that share paralogs with RPS16: view

No data available for Paralogs for RPS16 Gene

Variants for RPS16 Gene

Sequence variations from dbSNP and Humsavar for RPS16 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs17626 -- 39,435,881(-) AAGGG(C/T)CCGCT reference, synonymous-codon
rs17627 -- 39,433,312(+) CCAGG(A/G)CCTCC reference, synonymous-codon, utr-variant-3-prime
rs17628 -- 39,435,869(-) CAGTC(G/T)GTGCA synonymous-codon, reference
rs480595 -- 39,434,842(-) AAAAA(A/T)TTTTT intron-variant
rs480656 -- 39,434,821(+) aaaaa(C/G)aaCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPS16 Gene

Variant ID Type Subtype PubMed ID
nsv911679 CNV Loss 21882294
nsv911680 CNV Loss 21882294
dgv3860n71 CNV Loss 21882294
dgv3861n71 CNV Loss 21882294
nsv911685 CNV Loss 21882294
dgv3863n71 CNV Loss 21882294
nsv523856 CNV Loss 19592680

Relevant External Links for RPS16 Gene

HapMap Linkage Disequilibrium report
RPS16

Disorders for RPS16 Gene

(1) University of Copenhagen DISEASES for RPS16 Gene

Relevant External Links for RPS16

Genetic Association Database (GAD)
RPS16
Human Genome Epidemiology (HuGE) Navigator
RPS16
genes like me logo Genes that share disorders with RPS16: view

No data available for UniProtKB/Swiss-Prot for RPS16 Gene

Publications for RPS16 Gene

  1. Molecular cloning and sequence analysis of the human ribosomal protein S16. (PMID: 2016298) Batra S.K. … Hollingsworth M.A. (J. Biol. Chem. 1991) 2 3 4 23
  2. Interactions of human ribosomal proteins S16 and S5 with an 18S rRNA fragment containing their binding sites. (PMID: 19559069) Malygin A.A. … Karpova G.G. (Biochimie 2009) 3 23
  3. [Human ribosomal protein S16 inhibites excision of the first intron from its own]. (PMID: 20198863) Ivanov A.V. … Karpova G.G. (Mol. Biol. (Mosk.) 2010) 3 23
  4. [Binding of human ribosomal protein S16 with the 18S rRNA fragment 1203-1236/1521-1698]. (PMID: 18318121) Ian'shina D.D. … Karpova G.G. (Mol. Biol. (Mosk.) 2007) 3 23
  5. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PMID: 8706699) Vladimirov S.N. … Otto A. (Eur. J. Biochem. 1996) 3 4

Products for RPS16 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate RPS16
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for RPS16
    • Block miRNA regulation of RPS16 using miScript Target Protectors

    Sources for RPS16 Gene

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