Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RPS15A Gene

Aliases for RPS15A Gene

  • Ribosomal Protein S15a 2 3 5
  • Up-Regulated By HBV X Protein 3
  • 40S Ribosomal Protein S15a 3
  • S15a 3

External Ids for RPS15A Gene

Previous GeneCards Identifiers for RPS15A Gene

  • GC16M018285
  • GC16M018721
  • GC16M018760
  • GC16M017336

Summaries for RPS15A Gene

Entrez Gene Summary for RPS15A Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S8P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS15A Gene

RPS15A (Ribosomal Protein S15a) is a Protein Coding gene. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Metabolism. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPS15A Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS15A Gene

Genomics for RPS15A Gene

Regulatory Elements for RPS15A Gene

Enhancers for RPS15A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F018958 1 Ensembl ENCODE 4.8 -169.2 -169163 1.3 ELF3 PKNOX1 HLF INSM2 SP2 ZMYM3 FEZF1 ZEB2 SREBF1 GLIS1 RPS15A TMC7 ENSG00000260352
GH16F018961 0.7 ENCODE 4.9 -172.0 -172017 1.6 CTCF ZBTB11 ZFP64 ZNF266 ZBTB8A REST ZNF623 ZNF518A ZNF781 ZNF101 ENSG00000205746 PKD1P5 ENSG00000233024 RPS15A TMC7 ENSG00000260352
GH16F018786 1.2 ENCODE 0.8 +1.4 1407 5.0 MLX CREB3L1 ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 ENSG00000260017 ENSG00000262974 ENSG00000260242 ENSG00000205746 ARL6IP1 PKD1P5 COQ7 GC16M018782 RPS15A
GH16F018793 0.7 ENCODE 0.8 -2.9 -2871 0.2 MTA2 BACH1 DPF2 ARID1B ZNF121 SMARCA4 IKZF1 PBX2 ADNP HMBOX1 COQ7 RPS15A ENSG00000260342
GH16F018796 0.4 ENCODE 0.4 -6.2 -6231 0.2 REST ENSG00000260342 RPS15A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPS15A on UCSC Golden Path with GeneCards custom track

Promoters for RPS15A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000271188 483 2201 MLX CREB3L1 ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3

Genomic Location for RPS15A Gene

Chromosome:
16
Start:
18,781,295 bp from pter
End:
18,790,383 bp from pter
Size:
9,089 bases
Orientation:
Minus strand

Genomic View for RPS15A Gene

Genes around RPS15A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS15A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS15A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS15A Gene

Proteins for RPS15A Gene

  • Protein details for RPS15A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62244-RS15A_HUMAN
    Recommended name:
    40S ribosomal protein S15a
    Protein Accession:
    P62244
    Secondary Accessions:
    • P39027
    • P39031
    • Q3MHD9
    • Q8C023
    • Q9BV24

    Protein attributes for RPS15A Gene

    Size:
    130 amino acids
    Molecular mass:
    14840 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA44568.1; Type=Frameshift; Positions=24, 37; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPS15A Gene

neXtProt entry for RPS15A Gene

Post-translational modifications for RPS15A Gene

  • Ubiquitination at Lys 12, Lys 32, Lys 60, Lys 71, Lys 84, Lys 88, and Lys 124
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPS15A Gene

Domains & Families for RPS15A Gene

Gene Families for RPS15A Gene

Protein Domains for RPS15A Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RPS15A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62244

UniProtKB/Swiss-Prot:

RS15A_HUMAN :
  • Belongs to the ribosomal protein S8P family.
Family:
  • Belongs to the ribosomal protein S8P family.
genes like me logo Genes that share domains with RPS15A: view

Function for RPS15A Gene

Molecular function for RPS15A Gene

GENATLAS Biochemistry:
60S ribosomal protein S15A

Gene Ontology (GO) - Molecular Function for RPS15A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding NAS 9582194
GO:0003735 structural constituent of ribosome IEA,NAS 9582194
GO:0005515 protein binding IPI 24965446
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPS15A: view
genes like me logo Genes that share phenotypes with RPS15A: view

Animal Model Products

miRNA for RPS15A Gene

miRTarBase miRNAs that target RPS15A

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS15A Gene

Localization for RPS15A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS15A gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 4
mitochondrion 2

Gene Ontology (GO) - Cellular Components for RPS15A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 15108328
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with RPS15A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS15A Gene

Pathways & Interactions for RPS15A Gene

SuperPathways for RPS15A Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
.55
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing in the nucleus and cytosol
5 HIV Life Cycle
.45
genes like me logo Genes that share pathways with RPS15A: view

Pathways by source for RPS15A Gene

Gene Ontology (GO) - Biological Process for RPS15A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,NAS 9582194
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPS15A: view

No data available for SIGNOR curated interactions for RPS15A Gene

Transcripts for RPS15A Gene

Unigene Clusters for RPS15A Gene

Ribosomal protein S15a:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS15A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1: -
SP2: -
SP3:

Relevant External Links for RPS15A Gene

GeneLoc Exon Structure for
RPS15A
ECgene alternative splicing isoforms for
RPS15A

Expression for RPS15A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPS15A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPS15A Gene

This gene is overexpressed in Nasal epithelium (8.1) and Hair follicle (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPS15A Gene



Protein tissue co-expression partners for RPS15A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS15A Gene:

RPS15A

SOURCE GeneReport for Unigene cluster for RPS15A Gene:

Hs.370504
genes like me logo Genes that share expression patterns with RPS15A: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS15A Gene

Orthologs for RPS15A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS15A Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia RPS15A 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPS15A 34 35
  • 99.74 (n)
dog
(Canis familiaris)
Mammalia RPS15A 34
  • 94.87 (n)
-- 35
  • 94 (a)
OneToMany
-- 35
  • 72 (a)
OneToMany
cow
(Bos Taurus)
Mammalia RPS15A 34 35
  • 94.62 (n)
rat
(Rattus norvegicus)
Mammalia Rps15a 34
  • 89.23 (n)
mouse
(Mus musculus)
Mammalia Rps15a 34 16 35
  • 87.69 (n)
chicken
(Gallus gallus)
Aves RPS15A 34 35
  • 86.41 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 96 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rps15a 34
  • 83.85 (n)
Str.10134 34
zebrafish
(Danio rerio)
Actinopterygii rps15a 34 35
  • 83.08 (n)
wufb04b07 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9200 34
fruit fly
(Drosophila melanogaster)
Insecta RpS15A 36
  • 88 (a)
RpS15Ab 35
  • 88 (a)
OneToMany
CG12324 36
  • 87 (a)
RpS15Aa 34 35
  • 74.1 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009572 34
  • 68.97 (n)
worm
(Caenorhabditis elegans)
Secernentea rps-22 36 34 35
  • 69.49 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS22B 35
  • 76 (a)
OneToMany
RPS22A 34 35 37
  • 67.18 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR579W 34
  • 67.95 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B07931g 34
  • 66.92 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G39590 34
  • 68.97 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11200 35
  • 88 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU06431 34
  • 66.41 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps2202 34
  • 64.1 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5168 34
Species where no ortholog for RPS15A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS15A Gene

ENSEMBL:
Gene Tree for RPS15A (if available)
TreeFam:
Gene Tree for RPS15A (if available)

Paralogs for RPS15A Gene

(1) SIMAP similar genes for RPS15A Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with RPS15A: view

No data available for Paralogs for RPS15A Gene

Variants for RPS15A Gene

Sequence variations from dbSNP and Humsavar for RPS15A Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1049471 -- 18,792,068(-) AGTTG(A/C)AATCT upstream-variant-2KB, utr-variant-3-prime
rs111495152 -- 18,789,669(+) AGCAA(A/G)AGCCA intron-variant
rs111567159 -- 18,782,763(+) CTAAA(A/G)TATTT downstream-variant-500B
rs112362571 -- 18,789,220(+) CCACC(G/T)TGGCG intron-variant
rs112608196 -- 18,784,466(+) GTCTC(A/G)AACTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPS15A Gene

Variant ID Type Subtype PubMed ID
nsv984284 CNV duplication 23825009
nsv974777 CNV duplication 23825009
nsv833161 CNV loss 17160897
nsv469598 CNV gain 16826518
nsv428320 CNV loss 18775914
nsv1044846 CNV gain 25217958
esv3570409 CNV gain 25503493
esv34419 CNV gain 17911159
esv2758634 CNV gain+loss 17122850

Variation tolerance for RPS15A Gene

Residual Variation Intolerance Score: 51.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.05; 1.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS15A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPS15A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS15A Gene

Disorders for RPS15A Gene

Relevant External Links for RPS15A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPS15A

No disorders were found for RPS15A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPS15A Gene

Publications for RPS15A Gene

  1. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3 4 64
  2. Human S15a expression is upregulated by hepatitis B virus X protein. (PMID: 15108328) Lian Z. … Feitelson M.A. (Mol. Carcinog. 2004) 3 22 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PMID: 8706699) Vladimirov S.N. … Otto A. (Eur. J. Biochem. 1996) 3 4 64
  5. The primary structure of rat ribosomal protein S15a. (PMID: 8185605) Chan Y.-L. … Wool I.G. (Biochem. Biophys. Res. Commun. 1994) 3 4 64

Products for RPS15A Gene

Sources for RPS15A Gene

Content
Loading form....