Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RPS15A Gene

Aliases for RPS15A Gene

  • Ribosomal Protein S15a 2 3 5
  • Up-Regulated By HBV X Protein 3
  • S15a 3

External Ids for RPS15A Gene

Previous GeneCards Identifiers for RPS15A Gene

  • GC16M018285
  • GC16M018721
  • GC16M018760
  • GC16M017336

Summaries for RPS15A Gene

Entrez Gene Summary for RPS15A Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S8P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS15A Gene

RPS15A (Ribosomal Protein S15a) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPS15A Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS15A Gene

Genomics for RPS15A Gene

Regulatory Elements for RPS15A Gene

Enhancers for RPS15A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPS15A on UCSC Golden Path with GeneCards custom track

Promoters for RPS15A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPS15A on UCSC Golden Path with GeneCards custom track

Genomic Location for RPS15A Gene

Chromosome:
16
Start:
18,781,295 bp from pter
End:
18,790,383 bp from pter
Size:
9,089 bases
Orientation:
Minus strand

Genomic View for RPS15A Gene

Genes around RPS15A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS15A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS15A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS15A Gene

Proteins for RPS15A Gene

  • Protein details for RPS15A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62244-RS15A_HUMAN
    Recommended name:
    40S ribosomal protein S15a
    Protein Accession:
    P62244
    Secondary Accessions:
    • P39027
    • P39031
    • Q3MHD9
    • Q8C023
    • Q9BV24

    Protein attributes for RPS15A Gene

    Size:
    130 amino acids
    Molecular mass:
    14840 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA44568.1; Type=Frameshift; Positions=24, 37; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPS15A Gene

neXtProt entry for RPS15A Gene

Proteomics data for RPS15A Gene at MOPED

Post-translational modifications for RPS15A Gene

  • Ubiquitination at Lys 12, Lys 32, Lys 60, Lys 71, Lys 84, Lys 88, and Lys 124
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPS15A Gene

Domains & Families for RPS15A Gene

Gene Families for RPS15A Gene

Protein Domains for RPS15A Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RPS15A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62244

UniProtKB/Swiss-Prot:

RS15A_HUMAN :
  • Belongs to the ribosomal protein S8P family.
Family:
  • Belongs to the ribosomal protein S8P family.
genes like me logo Genes that share domains with RPS15A: view

Function for RPS15A Gene

Molecular function for RPS15A Gene

GENATLAS Biochemistry:
60S ribosomal protein S15A

Gene Ontology (GO) - Molecular Function for RPS15A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24965446
genes like me logo Genes that share ontologies with RPS15A: view
genes like me logo Genes that share phenotypes with RPS15A: view

Animal Model Products

miRNA for RPS15A Gene

miRTarBase miRNAs that target RPS15A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS15A Gene

Localization for RPS15A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS15A Gene COMPARTMENTS Subcellular localization image for RPS15A gene
Compartment Confidence
cytosol 5
extracellular 5

Gene Ontology (GO) - Cellular Components for RPS15A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with RPS15A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS15A Gene

Pathways & Interactions for RPS15A Gene

SuperPathways for RPS15A Gene

Superpath Contained pathways
1 Viral mRNA Translation
.60
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 Infectious disease
.48
5 rRNA processing
genes like me logo Genes that share pathways with RPS15A: view

Pathways by source for RPS15A Gene

Gene Ontology (GO) - Biological Process for RPS15A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006413 translational initiation TAS --
GO:0006415 translational termination TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPS15A: view

No data available for SIGNOR curated interactions for RPS15A Gene

Drugs & Compounds for RPS15A Gene

No Compound Related Data Available

Transcripts for RPS15A Gene

Unigene Clusters for RPS15A Gene

Ribosomal protein S15a:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPS15A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1: -
SP2: -
SP3:

Relevant External Links for RPS15A Gene

GeneLoc Exon Structure for
RPS15A
ECgene alternative splicing isoforms for
RPS15A

Expression for RPS15A Gene

mRNA expression in normal human tissues for RPS15A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPS15A Gene

This gene is overexpressed in Nasal epithelium (8.1) and Hair follicle (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS15A Gene



SOURCE GeneReport for Unigene cluster for RPS15A Gene Hs.370504

genes like me logo Genes that share expression patterns with RPS15A: view

Protein tissue co-expression partners for RPS15A Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS15A Gene

Orthologs for RPS15A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS15A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPS15A 35
  • 94.62 (n)
  • 98.46 (a)
RPS15A 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPS15A 35
  • 94.87 (n)
  • 100 (a)
-- 36
  • 94 (a)
OneToMany
-- 36
  • 72 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rps15a 35
  • 87.69 (n)
  • 100 (a)
Rps15a 16
Rps15a 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPS15A 35
  • 99.74 (n)
  • 100 (a)
RPS15A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rps15a 35
  • 89.23 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia RPS15A 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPS15A 35
  • 86.41 (n)
  • 99.23 (a)
RPS15A 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 96 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rps15a 35
  • 83.85 (n)
  • 99.23 (a)
Str.10134 35
zebrafish
(Danio rerio)
Actinopterygii rps15a 35
  • 83.08 (n)
  • 99.23 (a)
wufb04b07 35
rps15a 36
  • 99 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9200 35
fruit fly
(Drosophila melanogaster)
Insecta CG12324 37
  • 87 (a)
RpS15A 37
  • 88 (a)
RpS15Aa 35
  • 74.1 (n)
  • 88.46 (a)
RpS15Aa 36
  • 88 (a)
OneToMany
RpS15Ab 36
  • 88 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009572 35
  • 68.97 (n)
  • 83.08 (a)
worm
(Caenorhabditis elegans)
Secernentea rps-22 37
  • 86 (a)
rps-22 35
  • 69.49 (n)
  • 86.15 (a)
rps-22 36
  • 86 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR579W 35
  • 67.95 (n)
  • 76.92 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B07931g 35
  • 66.92 (n)
  • 76.15 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS22A 35
  • 67.18 (n)
  • 76.92 (a)
RPS22A 36
  • 77 (a)
OneToMany
RPS22B 36
  • 76 (a)
OneToMany
RPS22A 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G39590 35
  • 68.97 (n)
  • 73.08 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5168 35
bread mold
(Neurospora crassa)
Ascomycetes NCU06431 35
  • 66.41 (n)
  • 75.38 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps2202 35
  • 64.1 (n)
  • 74.62 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11200 36
  • 88 (a)
OneToOne
Species with no ortholog for RPS15A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS15A Gene

ENSEMBL:
Gene Tree for RPS15A (if available)
TreeFam:
Gene Tree for RPS15A (if available)

Paralogs for RPS15A Gene

(1) SIMAP similar genes for RPS15A Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with RPS15A: view

No data available for Paralogs for RPS15A Gene

Variants for RPS15A Gene

Sequence variations from dbSNP and Humsavar for RPS15A Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs17663059 -- 18,790,261(+) GATGG(C/T)GCCGA intron-variant, utr-variant-5-prime
rs9934032 -- 18,791,008(+) catca(C/T)acccg upstream-variant-2KB
rs17849525 -- 18,784,801(+) CGTCA(A/G)ATCTG reference, missense
rs28365938 -- 18,790,415(-) AGGCG(A/G)TCCTT upstream-variant-2KB
rs5816011 -- 18,787,753(+) TTGAG(-/C)CACCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPS15A Gene

Variant ID Type Subtype PubMed ID
esv587 CNV CNV 17122850
dgv822e1 CNV Complex 17122850
dgv823e1 CNV Complex 17122850
nsv428320 CNV Loss 18775914
esv34419 CNV Gain 17911159
dgv825e1 CNV Complex 17122850
nsv469598 CNV Gain 16826518
nsv833161 CNV Loss 17160897

Variation tolerance for RPS15A Gene

Residual Variation Intolerance Score: 51.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.05; 1.04% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RPS15A Gene

Disorders for RPS15A Gene

Relevant External Links for RPS15A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPS15A

No disorders were found for RPS15A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPS15A Gene

Publications for RPS15A Gene

  1. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3 4 67
  2. Human S15a expression is upregulated by hepatitis B virus X protein. (PMID: 15108328) Lian Z. … Feitelson M.A. (Mol. Carcinog. 2004) 3 23
  3. Proteomic discovery of MNT as a novel interacting partner of E3 ubiquitin ligase E6AP and a key mediator of myeloid differentiation. (PMID: 26506232) Kapoor I. … Trivedi A.K. (Oncotarget 2016) 3
  4. Reversible oxidation of phosphatase and tensin homolog (PTEN) alters its interactions with signaling and regulatory proteins. (PMID: 26561776) Verrastro I. … Pitt A.R. (Free Radic. Biol. Med. 2016) 3
  5. Decreased expression of RPS15A suppresses proliferation of lung cancer cells. (PMID: 25833696) Zhao X. … Wang J. (Tumour Biol. 2015) 3

Products for RPS15A Gene

Sources for RPS15A Gene

Content