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Aliases for RPS15 Gene

Aliases for RPS15 Gene

  • Ribosomal Protein S15 2 3 5
  • Homolog Of Rat Insulinoma 2 3
  • Insulinoma Protein 2 3
  • RIG 3 4
  • 40S Ribosomal Protein S15 2
  • RIG Protein 4
  • S15 3

External Ids for RPS15 Gene

Previous GeneCards Identifiers for RPS15 Gene

  • GC19M001605
  • GC19P001507
  • GC19P001379
  • GC19P001390
  • GC19P001392
  • GC19P001393
  • GC19P001212

Summaries for RPS15 Gene

Entrez Gene Summary for RPS15 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19P family of ribosomal proteins. It is located in the cytoplasm. This gene has been found to be activated in various tumors, such as insulinomas, esophageal cancers, and colon cancers. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

GeneCards Summary for RPS15 Gene

RPS15 (Ribosomal Protein S15) is a Protein Coding gene. Diseases associated with RPS15 include Chronic Lymphocytic Leukemia and Insulinoma. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPS15 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS15 Gene

Genomics for RPS15 Gene

Regulatory Elements for RPS15 Gene

Enhancers for RPS15 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPS15 on UCSC Golden Path with GeneCards custom track

Promoters for RPS15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPS15 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPS15 Gene

Chromosome:
19
Start:
1,438,358 bp from pter
End:
1,440,494 bp from pter
Size:
2,137 bases
Orientation:
Plus strand

Genomic View for RPS15 Gene

Genes around RPS15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS15 Gene

Proteins for RPS15 Gene

  • Protein details for RPS15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62841-RS15_HUMAN
    Recommended name:
    40S ribosomal protein S15
    Protein Accession:
    P62841
    Secondary Accessions:
    • A5D8V9
    • P11174
    • Q3KRA1
    • Q9UDC2

    Protein attributes for RPS15 Gene

    Size:
    145 amino acids
    Molecular mass:
    17040 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS15 Gene

neXtProt entry for RPS15 Gene

Proteomics data for RPS15 Gene at MOPED

Post-translational modifications for RPS15 Gene

  • Ubiquitination at Lys 65 and Lys 77
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPS15 Gene

Domains & Families for RPS15 Gene

Gene Families for RPS15 Gene

Protein Domains for RPS15 Gene

Suggested Antigen Peptide Sequences for RPS15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62841

UniProtKB/Swiss-Prot:

RS15_HUMAN :
  • Belongs to the ribosomal protein S19P family.
Family:
  • Belongs to the ribosomal protein S19P family.
genes like me logo Genes that share domains with RPS15: view

Function for RPS15 Gene

Molecular function for RPS15 Gene

GENATLAS Biochemistry:
40S ribosomal protein S15,16kDa,homolog to rig (rat insulinoma gene)

Gene Ontology (GO) - Molecular Function for RPS15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24725412
genes like me logo Genes that share ontologies with RPS15: view
genes like me logo Genes that share phenotypes with RPS15: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS15 Gene

Localization for RPS15 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS15 Gene COMPARTMENTS Subcellular localization image for RPS15 gene
Compartment Confidence
cytosol 5
nucleus 5
chloroplast 2

Gene Ontology (GO) - Cellular Components for RPS15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm NAS,TAS --
GO:0005829 cytosol TAS --
GO:0015935 small ribosomal subunit IEA --
GO:0016020 membrane IDA 16210410
genes like me logo Genes that share ontologies with RPS15: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS15 Gene

Pathways & Interactions for RPS15 Gene

SuperPathways for RPS15 Gene

Superpath Contained pathways
1 Viral mRNA Translation
.60
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 Infectious disease
.48
5 rRNA processing
genes like me logo Genes that share pathways with RPS15: view

Gene Ontology (GO) - Biological Process for RPS15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000056 ribosomal small subunit export from nucleus IMP 16037817
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing IMP,TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
genes like me logo Genes that share ontologies with RPS15: view

No data available for SIGNOR curated interactions for RPS15 Gene

Drugs & Compounds for RPS15 Gene

(1) Additional Compounds for RPS15 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RPS15: view

Transcripts for RPS15 Gene

Unigene Clusters for RPS15 Gene

Ribosomal protein S15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPS15 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4
SP1: -
SP2:
SP3: - -

Relevant External Links for RPS15 Gene

GeneLoc Exon Structure for
RPS15
ECgene alternative splicing isoforms for
RPS15

Expression for RPS15 Gene

mRNA expression in normal human tissues for RPS15 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS15 Gene



SOURCE GeneReport for Unigene cluster for RPS15 Gene Hs.406683

genes like me logo Genes that share expression patterns with RPS15: view

Protein tissue co-expression partners for RPS15 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS15 Gene

Orthologs for RPS15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS15 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPS15 35
  • 93.33 (n)
  • 99.31 (a)
RPS15 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPS15 35
  • 94.94 (n)
  • 100 (a)
RPS15 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rps15 35
  • 90.34 (n)
  • 100 (a)
Rps15 16
Gm4775 36
  • 84 (a)
OneToMany
Rps15 36
  • 100 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia RPS15 35
  • 99.08 (n)
  • 99.31 (a)
-- 36
  • 100 (a)
OneToMany
-- 36
  • 98 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rps15 35
  • 90.8 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia RPS15 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPS15 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPS15 35
  • 90.57 (n)
  • 100 (a)
RPS15 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPS15 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17045 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11968 35
zebrafish
(Danio rerio)
Actinopterygii rps15 36
  • 97 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8332 37
  • 77 (a)
RpS15 36
  • 74 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rps-15 37
  • 74 (a)
rps-15 36
  • 70 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL343C 35
  • 59.62 (n)
  • 61.27 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F07843g 35
  • 57.51 (n)
  • 61.27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS15 35
  • 56.81 (n)
  • 60.56 (a)
RPS15 36
  • 61 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G43640 35
  • 66.67 (n)
  • 74.64 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.925 35
barley
(Hordeum vulgare)
Liliopsida Hv.7206 35
rice
(Oryza sativa)
Liliopsida Os03g0798600 35
  • 74.02 (n)
  • 75.86 (a)
corn
(Zea mays)
Liliopsida Zm.6569 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00971 35
  • 71.6 (n)
  • 72.54 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps1502 35
  • 67.61 (n)
  • 73.94 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3293 36
  • 81 (a)
OneToOne
Species with no ortholog for RPS15:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS15 Gene

ENSEMBL:
Gene Tree for RPS15 (if available)
TreeFam:
Gene Tree for RPS15 (if available)

Paralogs for RPS15 Gene

genes like me logo Genes that share paralogs with RPS15: view

No data available for Paralogs for RPS15 Gene

Variants for RPS15 Gene

Sequence variations from dbSNP and Humsavar for RPS15 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs71174369 -- 1,437,833(+) GCAGC(-/C)TTGAC upstream-variant-2KB
rs71337016 -- 1,440,947(+) GCCAC(C/T)TGAGC downstream-variant-500B
rs139929695 -- 1,440,944(+) TGGGC(C/T)ACCTG downstream-variant-500B
rs73920485 -- 1,436,568(+) CAGTA(C/T)CCCTC upstream-variant-2KB
rs73920486 -- 1,438,282(+) TTGCC(C/T)TCCAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPS15 Gene

Variant ID Type Subtype PubMed ID
nsv910292 CNV Loss 21882294
dgv1055e1 CNV Complex 17122850
dgv3580n71 CNV Loss 21882294
dgv3583n71 CNV Loss 21882294
dgv3589n71 CNV Loss 21882294
dgv3596n71 CNV Loss 21882294
esv32942 CNV Gain+Loss 17666407
dgv3598n71 CNV Loss 21882294
nsv910491 CNV Gain+Loss 21882294
nsv910492 CNV Loss 21882294
dgv3599n71 CNV Loss 21882294
essv18235 CNV CNV 17122850
nsv833705 CNV Loss 17160897
nsv910499 CNV Loss 21882294
dgv3600n71 CNV Loss 21882294
dgv3601n71 CNV Loss 21882294
dgv3602n71 CNV Loss 21882294
nsv910507 CNV Loss 21882294
dgv3603n71 CNV Loss 21882294
nsv828377 CNV Loss 20364138

Variation tolerance for RPS15 Gene

Residual Variation Intolerance Score: 60.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS15 Gene

Human Gene Mutation Database (HGMD)
RPS15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS15 Gene

Disorders for RPS15 Gene

MalaCards: The human disease database

(3) MalaCards diseases for RPS15 Gene - From: Orphanet and GeneCards

Disorder Aliases PubMed IDs
chronic lymphocytic leukemia
  • cll
insulinoma
  • islet cell tumor
diamond-blackfan anemia
  • blackfan - diamond syndrome
- elite association - COSMIC cancer census association via MalaCards
Search RPS15 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RPS15

Tumor Gene Database (TGDB):
RPS15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPS15
genes like me logo Genes that share disorders with RPS15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS15 Gene

Publications for RPS15 Gene

  1. Isolation and characterization of the human homologue of rig and its pseudogenes: the functional gene has features characteristic of housekeeping genes. (PMID: 2159154) Shiga K. … Okamoto H. (Proc. Natl. Acad. Sci. U.S.A. 1990) 2 3 4 23 67
  2. Luzp4 defines a new mRNA export pathway in cancer cells. (PMID: 25662211) Viphakone N. … Wilson S.A. (Nucleic Acids Res. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for RPS15 Gene

Sources for RPS15 Gene

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