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Aliases for RPS15 Gene

Aliases for RPS15 Gene

  • Ribosomal Protein S15 2 3
  • RIG 3 4 6
  • 40S Ribosomal Protein S15 2 3
  • Homolog Of Rat Insulinoma 2 3
  • Insulinoma Protein 2 3
  • RIG Protein 4
  • S15 3

External Ids for RPS15 Gene

Summaries for RPS15 Gene

Entrez Gene Summary for RPS15 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19P family of ribosomal proteins. It is located in the cytoplasm. This gene has been found to be activated in various tumors, such as insulinomas, esophageal cancers, and colon cancers. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS15 Gene

RPS15 (Ribosomal Protein S15) is a Protein Coding gene. Diseases associated with RPS15 include insulinoma. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPS15 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS15 Gene

Genomics for RPS15 Gene

Genomic Location for RPS15 Gene

Start:
1,438,358 bp from pter
End:
1,440,494 bp from pter
Size:
2,137 bases
Orientation:
Plus strand

Genomic View for RPS15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPS15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS15 Gene

Regulatory Elements for RPS15 Gene

Proteins for RPS15 Gene

  • Protein details for RPS15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62841-RS15_HUMAN
    Recommended name:
    40S ribosomal protein S15
    Protein Accession:
    P62841
    Secondary Accessions:
    • A5D8V9
    • P11174
    • Q3KRA1
    • Q9UDC2

    Protein attributes for RPS15 Gene

    Size:
    145 amino acids
    Molecular mass:
    17040 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS15 Gene

neXtProt entry for RPS15 Gene

Proteomics data for RPS15 Gene at MOPED

Post-translational modifications for RPS15 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys65 and Lys77

No data available for DME Specific Peptides for RPS15 Gene

Domains for RPS15 Gene

Gene Families for RPS15 Gene

HGNC:
  • RPS :S ribosomal proteins

Protein Domains for RPS15 Gene

UniProtKB/Swiss-Prot:

RS15_HUMAN
Family:
  • Belongs to the ribosomal protein S19P family.:
    • P62841
genes like me logo Genes that share domains with RPS15: view

Function for RPS15 Gene

Molecular function for RPS15 Gene

GENATLAS Biochemistry: 40S ribosomal protein S15,16kDa,homolog to rig (rat insulinoma gene)

Gene Ontology (GO) - Molecular Function for RPS15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 2159154
GO:0003723 RNA binding --
GO:0003735 structural constituent of ribosome IBA --
GO:0005515 protein binding IPI 24725412
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPS15: view
genes like me logo Genes that share phenotypes with RPS15: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPS15 Gene

Localization for RPS15 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS15 Gene COMPARTMENTS Subcellular localization image for RPS15 gene
Compartment Confidence
cytosol 5
nucleus 5
chloroplast 2

Gene Ontology (GO) - Cellular Components for RPS15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 2159154
GO:0005654 nucleoplasm NAS 16037817
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome --
genes like me logo Genes that share ontologies with RPS15: view

Pathways for RPS15 Gene

SuperPathways for RPS15 Gene

Superpath Contained pathways
1 Influenza Viral RNA Transcription and Replication
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 CFTR translational fidelity (class I mutations)
.54
4 Disease
5 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
genes like me logo Genes that share pathways with RPS15: view

Pathways by source for RPS15 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for RPS15 Gene
1 BioSystems pathway for RPS15 Gene

Gene Ontology (GO) - Biological Process for RPS15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000028 ribosomal small subunit assembly IBA --
GO:0000056 ribosomal small subunit export from nucleus IMP 16037817
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0001649 osteoblast differentiation IDA 16210410
GO:0006364 rRNA processing IMP 18697920
genes like me logo Genes that share ontologies with RPS15: view

Compounds for RPS15 Gene

(1) Novoseek inferred chemical compound relationships for RPS15 Gene

Compound -log(P) Hits PubMed IDs
rrna 48.1 2
genes like me logo Genes that share compounds with RPS15: view

Transcripts for RPS15 Gene

Unigene Clusters for RPS15 Gene

Ribosomal protein S15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPS15 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4
SP1: -
SP2:
SP3: - -

Relevant External Links for RPS15 Gene

GeneLoc Exon Structure for
RPS15
ECgene alternative splicing isoforms for
RPS15

Expression for RPS15 Gene

mRNA expression in normal human tissues for RPS15 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS15 Gene

SOURCE GeneReport for Unigene cluster for RPS15 Gene Hs.406683

genes like me logo Genes that share expressions with RPS15: view

Orthologs for RPS15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 100 (a)
OneToMany
-- 37
  • 98 (a)
OneToMany
RPS15 36
  • 99.08 (n)
  • 99.31 (a)
cow
(Bos Taurus)
Mammalia RPS15 36
  • 93.33 (n)
  • 99.31 (a)
RPS15 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPS15 36
  • 94.94 (n)
  • 100 (a)
RPS15 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm4775 37
  • 84 (a)
OneToMany
Rps15 36
  • 90.34 (n)
  • 100 (a)
Rps15 16
Rps15 37
  • 100 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia RPS15 37
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPS15 37
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rps15 36
  • 90.8 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves RPS15 36
  • 90.57 (n)
  • 100 (a)
RPS15 37
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPS15 37
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17045 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11968 36
zebrafish
(Danio rerio)
Actinopterygii rps15 37
  • 97 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RpS15 37
  • 74 (a)
OneToOne
CG8332 38
  • 77 (a)
worm
(Caenorhabditis elegans)
Secernentea rps-15 37
  • 70 (a)
OneToOne
rps-15 38
  • 74 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL343C 36
  • 59.62 (n)
  • 61.27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS15 36
  • 56.81 (n)
  • 60.56 (a)
RPS15 37
  • 61 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F07843g 36
  • 57.51 (n)
  • 61.27 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.925 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G43640 36
  • 66.67 (n)
  • 74.64 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.7206 36
corn
(Zea mays)
Liliopsida Zm.6569 36
rice
(Oryza sativa)
Liliopsida Os03g0798600 36
  • 74.02 (n)
  • 75.86 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00971 36
  • 71.6 (n)
  • 72.54 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps1502 36
  • 67.61 (n)
  • 73.94 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3293 37
  • 81 (a)
OneToOne
Species with no ortholog for RPS15:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS15 Gene

ENSEMBL:
Gene Tree for RPS15 (if available)
TreeFam:
Gene Tree for RPS15 (if available)

Paralogs for RPS15 Gene

genes like me logo Genes that share paralogs with RPS15: view

No data available for Paralogs for RPS15 Gene

Variants for RPS15 Gene

Sequence variations from dbSNP and Humsavar for RPS15 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs3209076 -- 1,438,804(+) CCGCA(A/C)GATGG splice-acceptor-variant
rs3760995 -- 1,436,875(+) TGAGT(A/C)CAGTG upstream-variant-2KB
rs7251165 -- 1,438,866(+) GTGGA(C/T)CTCGA reference, synonymous-codon
rs7254516 -- 1,438,531(+) GCGGC(G/T)TGCTC intron-variant
rs34304908 -- 1,437,282(+) CGCCC(-/C)AGCCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPS15 Gene

Variant ID Type Subtype PubMed ID
nsv910292 CNV Loss 21882294
dgv1055e1 CNV Complex 17122850
dgv3580n71 CNV Loss 21882294
dgv3583n71 CNV Loss 21882294
dgv3589n71 CNV Loss 21882294
dgv3596n71 CNV Loss 21882294
esv32942 CNV Gain+Loss 17666407
dgv3598n71 CNV Loss 21882294
nsv910491 CNV Gain+Loss 21882294
nsv910492 CNV Loss 21882294
dgv3599n71 CNV Loss 21882294
essv18235 CNV CNV 17122850
nsv833705 CNV Loss 17160897
nsv910499 CNV Loss 21882294
dgv3600n71 CNV Loss 21882294
dgv3601n71 CNV Loss 21882294
dgv3602n71 CNV Loss 21882294
nsv910507 CNV Loss 21882294
dgv3603n71 CNV Loss 21882294
nsv828377 CNV Loss 20364138

Relevant External Links for RPS15 Gene

HapMap Linkage Disequilibrium report
RPS15
Human Gene Mutation Database (HGMD)
RPS15

Disorders for RPS15 Gene

(1) MalaCards Diseases for RPS15 Gene

Search for RPS15 Gene in MalaCards »

(2) University of Copenhagen DISEASES for RPS15 Gene

Relevant External Links for RPS15

Tumor Gene Database (TGDB):
RPS15
genes like me logo Genes that share disorders with RPS15: view

No data available for UniProtKB/Swiss-Prot for RPS15 Gene

Publications for RPS15 Gene

  1. Isolation and characterization of the human homologue of rig and its pseudogenes: the functional gene has features characteristic of housekeeping genes. (PMID: 2159154) Shiga K. … Okamoto H. (Proc. Natl. Acad. Sci. U.S.A. 1990) 2 3 4 23
  2. Evolutionary conservation of the insulinoma gene rig and its possible function. (PMID: 2821540) Inoue C. … Okamoto H. (Proc. Natl. Acad. Sci. U.S.A. 1987) 3 4
  3. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PMID: 8706699) Vladimirov S.N. … Otto A. (Eur. J. Biochem. 1996) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes. (PMID: 15883184) Yu Y. … Leary J.A. (Protein Sci. 2005) 3

Products for RPS15 Gene

Sources for RPS15 Gene

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