RPS15 Gene
protein-coding GIFtS: 59
GCID: GC19P001438
|
|
ribosomal protein S15
| |
Aliases for RPS15 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Ribosomal Protein S151 2 | | 40S Ribosomal Protein S152 | | RIG1 2 3 5 | | Homolog Of Rat Insulinoma2 | | S151 2 | | Insulinoma Protein2 | | MGC1111301 | | RIG Protein3 |
Export aliases for RPS15 gene to outside databasesPrevious GC identifers: GC19M001605 GC19P001507 GC19P001379 GC19P001390 GC19P001392 GC19P001393 GC19P001212 |
Summaries for RPS15 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for RPS15: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This geneencodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19P family ofribosomal proteins. It is located in the cytoplasm. This gene has been found to be activated in various tumors, suchas insulinomas, esophageal cancers, and colon cancers. As is typical for genes encoding ribosomal proteins, there aremultiple processed pseudogenes of this gene dispersed through the genome. (provided by RefSeq, Jul 2008) Gene Wiki entry for RPS15
|
Genomic Views for RPS15 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the RPS15 gene promoter: NF-1 p53 NRSF form 1 NRSF form 2 C/EBPalpha Other transcription factors
Search SABiosciences Chromatin IP Primers for RPS15
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS15 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3RPS15 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P001438: view genomic region
(about GC identifiers)
Start:
|
1,438,358 bp from pter |
End:
|
1,441,066 bp from pter |
Size:
|
2,709 bases |
Orientation:
|
plus strand |
|
Proteins for RPS15 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: RS15_HUMAN, P62841 (See
protein sequence)Recommended Name: 40S ribosomal protein S15 Size: 145 amino acids; 17040 Da
Secondary accessions: A5D8V9 P11174 Q3KRA1 Q9UDC2Explore the universe of human proteins at neXtProt for RPS15: NX_P62841
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P62841 RPS15 Protein expression data from MOPED and PaxDb: About this image 
 REFSEQ proteins: NP_001009.1 ENSEMBL proteins: ENSP00000467676 ENSP00000466010 ENSP00000467466 ENSP00000465055 ENSP00000467855 ENSP00000466366 Reactome Protein details: P62841 Human Recombinant Protein Products for RPS15:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
RPS15 for ontologies About GeneDecksing
RPS15 Antibody Products: Assay Products for RPS15: |
Protein
Domains / Families for RPS15 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RPS15 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P62841ProtoNet protein and cluster: P62841 UniProtKB/Swiss-Prot: RS15_HUMAN, P62841Similarity: Belongs to the ribosomal protein S19P family |
Function for RPS15 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Molecular Function: Genatlas biochemistry entry for RPS15:40S ribosomal protein S15,16kDa,homolog to rig (rat insulinoma gene)
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
RPS15 for ontologies About GeneDecksing
Phenotypes: 9 GenomeRNAi human phenotypes for RPS15: Animal Models:
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPS15 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPS15 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for RPS15 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPS15  |
|
Pathways & Interactions for RPS15 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Synthesis of PB1-F2 | | | 2 | Translation initiation complex formation | | | 3 | Metabolism of mRNA | | | 4 | Disease | | | 5 | Generic Transcription Pathway | |
Pathway sources See GeneCards unified pathways Show all pathways
1 GeneGo (Thomson Reuters) Pathway for RPS15 1 BioSystems Pathway for RPS15 
5/32
Reactome Pathways for RPS15 (see all 32)
1
Kegg Pathway (Kegg details for RPS15):
RPS15 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPS15
5/113 Interacting proteins for RPS15 (P628411, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 113)About this table
Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table
RPS15 for ontologies About GeneDecksing
|
Drugs & Compounds for RPS15 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
RPS15 for compounds About GeneDecksing
Browse Tocris compounds for RPS15 1 Novoseek chemical compound relationship for RPS15 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| rrna |
48.1 |
2 |
15627386 (1), 12527771 (1) |
Search CenterWatch for drugs/clinical trials and news about RPS15 / RS15 
|
Transcripts for RPS15 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for RPS15 gene: NM_001018.3 Unigene Cluster for RPS15: Ribosomal protein S15 Hs.406683 [show with all ESTs]Unigene Representative Sequence: BM92358412 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000233609(uc002lsp.1) ENST00000586686 ENST00000591032 ENST00000592623 ENST00000586656 ENST00000593052 ENST00000592700 ENST00000591804 ENST00000592588 ENST00000586096 ENST00000589656 ENST00000585665
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPS15 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPS15 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RPS15 (NM_001018) | |  | DNA2.0 Custom Codon Optimized Gene
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Additional cDNA sequence: AF145025.1 BC006431.1 BC064908.1 BC080543.1 BC105810.1 BC141832.1 J02984.1 24/45 DOTS entries (see all 45): DT.95306708 DT.100000362 DT.87005888 DT.97856873 DT.95373636 DT.97870281 DT.99926591 DT.101985948 DT.453456 DT.121494982 DT.100894797 DT.95193492 DT.97868940 DT.95096643 DT.100695541 DT.92467871 DT.40202447 DT.100695533 DT.95373692 DT.100695536 DT.120989856 DT.120989860 DT.121495068 DT.92467873 24/1397 AceView cDNA sequences (see all 1397): BU726264 BU539823 CD385238 BU075869 BE793105 BM559229 BU507059 BQ430302 CA434031 CR626076 CA772071 BU838115 BM757277 CB124133 BU077485 AI188924 BU930930 BE906540 AI696112 BE255031 BQ682522 BU789785 BE254190 BM017285 GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for RPS15 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | |
| SP1: | |   | |   | - |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | - |   | - |   | |   | |   | |   |
ECgene alternative splicing isoforms for RPS15
|
Expression for RPS15 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RPS15 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: ACTCCAAAAA
 About this image See RPS15 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for RPS15
SOURCE GeneReport for Unigene cluster: Hs.406683 SABiosciences Custom PCR Arrays for RPS15
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPS15 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RPS15 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS15 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS15 |
Orthologs for RPS15 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RPS15 gene from 10/41 species (see all 41) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
mouse (Mus musculus) |
Mammalia |
Rps151 , 5 |
ribosomal protein S151, 5 |
90.34(n)1 100(a)1 |
  |
10 (39.72 cM)5 200541 NM_009091.21 NP_033117.11 802924535 |
chicken (Gallus gallus) |
Aves |
RPS151 |
ribosomal protein S15 |
90.57(n) 100(a) |
  |
396448 NM_205462.1 NP_990793.1 |
lizard (Anolis carolinensis) |
Reptilia |
RPS156 |
-- |
86(a) |
1 ↔ 1 |
5(138090998-138091195) |
African clawed frog (Xenopus laevis) |
Amphibia |
BC053812.12 |
-- |
82.26(n) |
  |
BC053812.1 |
zebrafish (Danio rerio) |
Actinopterygii |
rps151 |
ribosomal protein S15 |
84.37(n) 97.24(a) |
  |
337148 NM_001001819.1 NP_001001819.1 |
fruit fly (Drosophila melanogaster) |
Insecta |
CG83323 RpS151 |
protein biosynthesis structural constituent of more3 Ribosomal protein S151 |
77(a)3 76.32(n)1 76.55(a)1 |
  |
53C83 368511 NM_166183.21 NP_725591.11 |
worm (Caenorhabditis elegans) |
Secernentea |
rps-151 , 3 |
40S ribosomal protein S153 Protein RPS-151 |
74(a)3 67.61(n)1 74.47(a)1 |
  |
I(8823323-8824262)3 1726931 NM_059983.41 NP_492384.11 |
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes |
RPS151 |
Rps15p |
56.81(n) 60.56(a) |
  |
854117 NP_014602.1 |
thale cress (Arabidopsis thaliana) |
eudicotyledons |
AT5G436401 |
40S ribosomal protein S15-5 |
66.67(n) 74.64(a) |
  |
834384 NM_123730.1 NP_199177.1 |
rice (Oryza sativa) |
Liliopsida |
NM_185052.12 |
-- |
79.17(n) |
  |
NM_185052.1 |
ENSEMBL Gene Tree for RPS15 (if available) TreeFam Gene Tree for RPS15 (if available)  |
Paralogs for RPS15 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for RPS15 gene
RPS15 for paralogs About GeneDecksing
5/9 Pseudogenes.org Pseudogenes for RPS15 (see all 9) PGOHUM00000239299 PGOHUM00000247094 PGOHUM00000234113 PGOHUM00000244484 PGOHUM00000244855
|
Genomic Variants for RPS15 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 19 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for RPS15 (1438358 - 1441066 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 3 variations for RPS15 3 CNVs: 7191 4066 5066 Human Gene Mutation Database (HGMD): RPS15
 | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPS15 |
|
Disorders
/ Diseases for RPS15 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RPS15 for disorders About GeneDecksing
OMIM gene information: 180535
OMIM disorders: --
10 diseases for RPS15: About MalaCardsinsulinoma diamond-blackfan anemia esophageal cancer colon cancer esophagitis cleft palate fanconi's anemia anemia spasticity malaria 2 diseases from the University of Copenhagen DISEASES database for RPS15:Insulinoma Diamond-Blackfan anemia Tumor Gene Database (TGDB): RPS15 Export disorders for RPS15 gene to outside databases
|
Publications for RPS15 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RPS15 gene, integrated from 9 sources (see all 53): (articles sorted by number of sources associating them with RPS15) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Isolation and characterization of the human homologue of rig and its pseudogenes: the functional gene has features characteristic of housekeeping genes. (PubMed id 2159154)1, 2, 3, 9 Shiga K.... Okamoto H. (1990)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699)1, 2 Vladimirov S.N.... Otto A. (1996)
- Evolutionary conservation of the insulinoma gene rig and its possible function. (PubMed id 2821540)1, 2 Inoue C.... Okamoto H. (1987)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
- Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
|
External Searches for RPS15 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RPS15 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RPS15 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RPS15 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
|
About This Section
| Patent Information for RPS15 gene: Search GeneIP for patents involving RPS15
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for RPS15 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory) About This Section
|
 | |
 | |
 |
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