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RPS15 Gene

protein-coding   GIFtS: 61
GCID: GC19P001438

Ribosomal Protein S15

  See RPS15-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribosomal Protein S151 2     Insulinoma Protein1 2
RIG2 3 5     S152
40S Ribosomal Protein S151 2     RIG Protein3
Homolog Of Rat Insulinoma1 2     

External Ids:    HGNC: 103881   Entrez Gene: 62092   Ensembl: ENSG000001152687   OMIM: 1805355   UniProtKB: P628413   

Export aliases for RPS15 gene to outside databases

Previous GC identifers: GC19M001605 GC19P001507 GC19P001379 GC19P001390 GC19P001392 GC19P001393 GC19P001212


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RPS15 Gene:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This
gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19P family
of ribosomal proteins. It is located in the cytoplasm. This gene has been found to be activated in various
tumors, such as insulinomas, esophageal cancers, and colon cancers. As is typical for genes encoding ribosomal
proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. (provided by
RefSeq, Jul 2008)

GeneCards Summary for RPS15 Gene:
RPS15 (ribosomal protein S15) is a protein-coding gene. Diseases associated with RPS15 include insulinoma. GO annotations related to this gene include structural constituent of ribosome and RNA binding.

Gene Wiki entry for RPS15 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the RPS15 gene promoter:
         NF-1   p53   NRSF form 1   NRSF form 2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPS15 promoter sequence
   Search Chromatin IP Primers for RPS15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RPS15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

RPS15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS15 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P001438:  view genomic region     (about GC identifiers)

Start:
1,438,358 bp from pter      End:
1,440,583 bp from pter
Size:
2,226 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RS15_HUMAN, P62841 (See protein sequence)
Recommended Name: 40S ribosomal protein S15  
Size: 145 amino acids; 17040 Da
2 PDB 3D structures from and Proteopedia for RPS15:
2ZKQ (3D)        3J3A (3D)    
Secondary accessions: A5D8V9 P11174 Q3KRA1 Q9UDC2

Explore the universe of human proteins at neXtProt for RPS15: NX_P62841

Explore proteomics data for RPS15 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys65, Lys77
  • Modification sites at PhosphoSitePlus

  • See RPS15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001009.1  
    ENSEMBL proteins: 
     ENSP00000473953   ENSP00000467676   ENSP00000474970   ENSP00000474433   ENSP00000475096  
     ENSP00000467855   ENSP00000466010   ENSP00000465055   ENSP00000474543   ENSP00000466366  
     ENSP00000467466  
    Reactome Protein details: P62841

    RPS15 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for RPS15

     
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    antibodies-online proteins for RPS15 (15 products) 

     
    antibodies-online peptides for RPS15

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    antibodies-online kits for RPS15 (24 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RPS: S ribosomal proteins

    4 InterPro protein domains:
     IPR023575 Ribosomal_S19_SF
     IPR005713 Ribosomal_S19A/S15e
     IPR002222 Ribosomal_S19
     IPR020934 Ribosomal_S19_CS

    Graphical View of Domain Structure for InterPro Entry P62841

    ProtoNet protein and cluster: P62841

    UniProtKB/Swiss-Prot: RS15_HUMAN, P62841
    Similarity: Belongs to the ribosomal protein S19P family


    Find genes that share domains with RPS15           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for RPS15:
    40S ribosomal protein S15,16kDa,homolog to rig (rat insulinoma gene)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS2159154
    GO:0003723RNA binding ----
    GO:0003735structural constituent of ribosome IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with RPS15           About GenesLikeMe


    Phenotypes:
         9 GenomeRNAi human phenotypes for RPS15:
     Decreased Hepatitis C virus re  Decreased homologous recombina  Decreased viability  Decreased viability of wild-ty 
     Increased S DNA content  Nuclear 40S maturation defects  Nucleolar pre-40S maturation d  S arrest 
     Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RPS15

    miRNA
    Products:
        
    miRTarBase miRNAs that target RPS15:
    hsa-mir-92a-3p (MIRT049096), hsa-mir-18a-3p (MIRT040870), hsa-mir-124-3p (MIRT022282), hsa-mir-99a-5p (MIRT048661), hsa-mir-1260b (MIRT052682), hsa-mir-615-3p (MIRT039745), hsa-mir-1229-3p (MIRT036366), hsa-mir-505-3p (MIRT041056), hsa-mir-100-5p (MIRT048590), hsa-mir-484 (MIRT041653)

    Block miRNA regulation of human, mouse, rat RPS15 using miScript Target Protectors
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS15


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5
    chloroplast2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS2159154
    GO:0005654nucleoplasm NAS16037817
    GO:0005829cytosol TAS--
    GO:0005840ribosome ----
    GO:0015935small ribosomal subunit ----

    Find genes that share ontologies with RPS15           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RPS15 About   (see all 6)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CFTR translational fidelity class I mutations
    CFTR translational fidelity class I mutations 0.60
    Ribosome0.54
    Cytoplasmic Ribosomal Proteins0.60
    2Influenza Viral RNA Transcription and Replication
    Viral mRNA Translation0.94
    Eukaryotic Translation Initiation0.89
    Peptide chain elongation0.94
    Cap-dependent Translation Initiation0.89
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    Formation of a pool of free 40S subunits0.94
    Nonsense-Mediated Decay0.89
    3Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
    Translation initiation complex formation0.91
    Ribosomal scanning and start codon recognition0.91
    Formation of the ternary complex, and subsequently, the 43S complex0.91
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.90
    4Gene Expression
    Gene Expression0.40
    5Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30


    Find genes that share SuperPaths with RPS15           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPS15
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPS15
        Cytoplasmic Ribosomal Proteins

    Selected Reactome Pathways for RPS15 (see all 12)
        Peptide chain elongation
    Formation of the ternary complex, and subsequently, the 43S complex
    Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
    Viral mRNA Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit


    1 Kegg Pathway  (Kegg details for RPS15):
        Ribosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RPS15
    Interactions:

        Search GeneGlobe Interaction Network for RPS15

    Selected Interacting proteins for RPS15 (P628411, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 116)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UPF2Q9HAU51, 3EBI-372635,EBI-372073 I2D: score=4 
    ENSG00000096150P622693I2D: score=5 
    ENSG00000223367P622693I2D: score=5 
    ENSG00000226225P622693I2D: score=5 
    ENSG00000235650P622693I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000056ribosomal small subunit export from nucleus IMP16037817
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006364rRNA processing IMP18697920
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--

    Find genes that share ontologies with RPS15           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RPS15 (RS15)

    1 Novoseek inferred chemical compound relationship for RPS15 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rrna 48.1 2 15627386 (1), 12527771 (1)



    Find genes that share compounds with RPS15           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RPS15 gene: 
    NM_001018.3  

    Unigene Cluster for RPS15:

    Ribosomal protein S15
    Hs.406683  [show with all ESTs]
    Unigene Representative Sequence: BM923584
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000233609(uc002lsp.1) ENST00000586686 ENST00000591032 ENST00000592623
    ENST00000586656 ENST00000589656 ENST00000593052 ENST00000586096 ENST00000591804
    ENST00000592700 ENST00000585665 ENST00000592588
    miRNA
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    GenScript: all cDNA clones in your preferred vector: RPS15 (NM_001018)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat RPS15
      QuantiFast Probe-based Assays in human, mouse, rat RPS15

    Additional mRNA sequence: 

    AF145025.1 BC006431.1 BC064908.1 BC080543.1 BC105810.1 BC141832.1 J02984.1 

    Selected DOTS entries (see all 45):

    DT.95306708  DT.100000362  DT.87005888  DT.97856873  DT.95373636  DT.97870281  DT.99926591  DT.101985948 
    DT.453456  DT.121494982  DT.100894797  DT.95193492  DT.97868940  DT.95096643  DT.100695541  DT.92467871 
    DT.40202447  DT.100695533  DT.95373692  DT.100695536  DT.120989856  DT.120989860  DT.121495068  DT.92467873 

    Selected AceView cDNA sequences (see all 1397):

    BM790363 CA434031 AI283030 BQ883471 AI290933 CD106986 BU179394 BU190892 
    AI804751 NM_018959 AW162417 CD671957 BM894362 BE293961 CB111889 CD514410 
    T94178 AI927099 BM966795 BQ675767 BQ709540 BG683261 AI360685 BG334630 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for RPS15    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4
    SP1:              -                           
    SP2:                                          
    SP3:              -     -                     


    ECgene alternative splicing isoforms for RPS15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RPS15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTCCAAAAA
    RPS15 Expression
    About this image

    RPS15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RPS15 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.406683
        Custom PCR Arrays for RPS15
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPS15 gene from Selected species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rps151 , 5 ribosomal protein S151, 5 90.34(n)1
    100(a)1
      10 (39.72 cM)5
    200541  NM_009091.21  NP_033117.11 
     802924535 
    chicken
    (Gallus gallus)
    Aves RPS151 ribosomal protein S15 90.57(n)
    100(a)
      396448  NM_205462.1  NP_990793.1 
    lizard
    (Anolis carolinensis)
    Reptilia RPS156
    ribosomal protein S15
    86(a)
    1 ↔ 1
    5(138090998-138091195)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC053812.12   -- 82.26(n)    BC053812.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rps156
    ribosomal protein S15
    97(a)
    1 ↔ 1
    11(5961412-5966184) ENSDARG00000070849
    fruit fly
    (Drosophila melanogaster)
    Insecta CG83323 protein biosynthesis structural
    constituent of more
    77(a)   53C8   --
    worm
    (Caenorhabditis elegans)
    Secernentea rps-153 40S ribosomal protein S15 74(a)   I(8823323-8824262)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPS151 RPS15 56.81(n)
    60.56(a)
      854117   NP_014602.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G436401 AT5G43640 66.67(n)
    74.64(a)
      834384  NM_123730.1  NP_199177.1 
    rice
    (Oryza sativa)
    Liliopsida NM_185052.12   -- 79.17(n)    NM_185052.1 


    ENSEMBL Gene Tree for RPS15 (if available)
    TreeFam Gene Tree for RPS15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RPS15 gene

    Find genes that share paralogs with RPS15           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for RPS15 (see all 9)
    PGOHUM00000239299 PGOHUM00000247094 PGOHUM00000234113 PGOHUM00000244484 PGOHUM00000244855


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RPS15 (see all 127)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1388607681,2
    C--1366337(+) TACTC-/CTTCTCTT 1 -- us2k10--------
    rs1883077561,2
    --1366345(+) CTCTTC/TGAGCT 1 -- us2k10--------
    rs1932910781,2
    --1366544(+) ATTCTC/TTTATG 1 -- us2k10--------
    rs1167867551,2
    C,F--1366646(+) AAAGCC/TGGAAT 1 -- us2k11Minor allele frequency- T:0.06WA 118
    rs1419982101,2
    C--1366669(+) AGGCCC/-TGTCC 1 -- us2k11Minor allele frequency- -:0.01NS 146
    rs1141943351,2
    C,F--1366703(+) ATTCTC/TGTGTT 1 -- us2k11Minor allele frequency- T:0.01NS 146
    rs1127394691,2
    C,F--1366836(+) AGGGGC/TGGCGA 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1458436441,2
    F--1366902(+) CTGCTC/GTAATC 1 -- us2k11Minor allele frequency- G:0.01NS 148
    rs739204861,2
    C,F--1366928(+) TTGCCC/TTCCAG 1 -- us2k13Minor allele frequency- T:0.02WA NS 268
    rs2013904491,2
    C--1367049(+) AAGCGA/CTCTCT 1 -- ut511Minor allele frequency- C:0.00EU 1227

    HapMap Linkage Disequilibrium report for RPS15 (1438358 - 1440583 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RPS15 (see all 20):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3589n71CNV Loss21882294
    nsv910292CNV Loss21882294
    nsv910499CNV Loss21882294
    nsv828377CNV Loss20364138
    dgv3596n71CNV Loss21882294
    dgv3601n71CNV Loss21882294
    nsv910492CNV Loss21882294
    nsv910507CNV Loss21882294
    dgv3603n71CNV Loss21882294
    dgv3580n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): RPS15
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RPS15
    DNA2.0 Custom Variant and Variant Library Synthesis for RPS15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 180535    OMIM disorders: --

    1 disease for RPS15:    
    About MalaCards
    insulinoma

    2 diseases from the University of Copenhagen DISEASES database for RPS15:
    Insulinoma     Diamond-Blackfan anemia

    Find genes that share disorders with RPS15           About GenesLikeMe

    Tumor Gene Database (TGDB): RPS15

    Export disorders for RPS15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for RPS15 gene, integrated from 10 sources (see all 63):
    (articles sorted by number of sources associating them with RPS15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of the human homologue of rig and its pseudogenes: the functional gene has features characteristic of housekeeping genes. (PubMed id 2159154)1, 2, 3, 9 Shiga K.... Okamoto H. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699)1, 2 Vladimirov S.N.... Otto A. (Eur. J. Biochem. 1996)
    4. Evolutionary conservation of the insulinoma gene rig and its possible function. (PubMed id 2821540)1, 2 Inoue C.... Okamoto H. (Proc. Natl. Acad. Sci. U.S.A. 1987)
    5. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)
    6. Ribosomal proteins RPL37, RPS15 and RPS20 regulate the Mdm2-p53-MdmX network. (PubMed id 23874713)1 Daftuar L....Prives C. (PLoS ONE 2013)
    7. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    8. Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. (PubMed id 23184937)1 Xie Y....Cong F. (J. Biol. Chem. 2013)
    9. Structures of the human and Drosophila 80S ribosome. (PubMed id 23636399)2 Anger A.M.... Beckmann R. (Nature 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 6209 HGNC: 10388 AceView: RPS15andDAZAP1 Ensembl:ENSG00000115268 euGenes: HUgn6209
    ECgene: RPS15 Kegg: 6209 H-InvDB: RPS15

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RPS15 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RPS15 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RPS15 gene:
    Search GeneIP for patents involving RPS15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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