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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPS14 Gene

protein-coding   GIFtS: 63
GCID: GC05M149803

Ribosomal Protein S14

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ribosomal Protein S141 2
40S Ribosomal Protein S141 2
Emetine Resistance1 2
EMTB2 5
S142

External Ids:    HGNC: 103871   Entrez Gene: 62082   Ensembl: ENSG000001645877   OMIM: 1306205   UniProtKB: P622633   

Export aliases for RPS14 gene to outside databases

Previous GC identifers: GC05M149892 GC05M150420 GC05M149805 GC05M149852 GC05M144971


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RPS14 Gene:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This
gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S11P family
of ribosomal proteins. It is located in the cytoplasm. Transcript variants utilizing alternative transcription
initiation sites have been described in the literature. As is typical for genes encoding ribosomal proteins,
there are multiple processed pseudogenes of this gene dispersed through the genome. In Chinese hamster ovary
cells, mutations in this gene can lead to resistance to emetine, a protein synthesis inhibitor. Multiple
alternatively spliced transcript variants encoding the same protein have been found for this gene. (provided by
RefSeq, Jul 2008)

GeneCards Summary for RPS14 Gene: 
RPS14 (ribosomal protein S14) is a protein-coding gene. Diseases associated with RPS14 include macrocytic anemia, refractory, due to 5q deletion, somatic, and chromosome 5q deletion, and among its related super-pathways are Eukaryotic Translation Initiation and Formation of the ternary complex, and subsequently, the 43S complex. GO annotations related to this gene include translation regulator activity and RNA binding.

Gene Wiki entry for RPS14 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_029289.11  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPS14 gene promoter:
         HOXA9B   HOXA9   ER-alpha   TBP   Egr-1   MyoD   Nkx2-5   Nkx5-1   CREB   deltaCREB   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for RPS14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31-q33   Ensembl cytogenetic band:  5q33.1   HGNC cytogenetic band: 5q31-q33

RPS14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS14 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M149803:  view genomic region     (about GC identifiers)

Start:
149,822,753 bp from pter      End:
149,829,319 bp from pter
Size:
6,567 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RS14_HUMAN, P62263 (See protein sequence)
Recommended Name: 40S ribosomal protein S14  
Size: 151 amino acids; 16273 Da
1 PDB 3D structure from and Proteopedia for RPS14:
3J3A (3D)    
Secondary accessions: B2R5G5 D3DQG5 P06366 Q5BJI0

Explore the universe of human proteins at neXtProt for RPS14: NX_P62263

Explore proteomics data for RPS14 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P62263

  • RPS14 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RPS14 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001020241.1  NP_001020242.1  NP_005608.1  

    ENSEMBL proteins: 
     ENSP00000385958   ENSP00000428509   ENSP00000429856   ENSP00000311028   ENSP00000428536  
     ENSP00000385425  
    Reactome Protein details: P62263
    Human Recombinant Protein Products for RPS14: 
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    Cloud-Clone Corp. Proteins for RPS14 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IDA9152021
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--
    GO:0005840ribosome ----
    GO:0022627cytosolic small ribosomal subunit IDA15883184

    RPS14 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RPS: S ribosomal proteins

    2 InterPro protein domains:
     IPR018102 Ribosomal_S11_CS
     IPR001971 Ribosomal_S11

    Graphical View of Domain Structure for InterPro Entry P62263

    ProtoNet protein and cluster: P62263

    UniProtKB/Swiss-Prot: RS14_HUMAN, P62263
    Similarity: Belongs to the ribosomal protein S11P family


    RPS14 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for RPS14:
    40S ribosomal protein S14,16kDa

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding ISS--
    GO:0003735structural constituent of ribosome IEA--
    GO:0045182translation regulator activity IMP3683397
    GO:0048027mRNA 5'-UTR binding IDA7867928
         
    RPS14 for ontologies           About GeneDecksing


    Phenotypes:
         9 GenomeRNAi human phenotypes for RPS14:
     Decreased Hepatitis C virus re  Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 
     Decreased viability  Decreased viability of wild-ty  Nuclear 40S maturation defects  Nuclear pre-40S maturation def 
     Synthetic lethal with Ras 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RPS14 About   (see all 6)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Viral mRNA Translation
    Influenza Life Cycle0.95
    3' -UTR-mediated translational regulation0.93
    Influenza Infection0.95
    L13a-mediated translational silencing of Ceruloplasmin expression0.93
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Formation of a pool of free 40S subunits0.90
    Eukaryotic Translation Termination0.94
    Nonsense-Mediated Decay0.84
    2Translation initiation complex formation
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.95
    Formation of the ternary complex, and subsequently, the 43S complex0.87
    Ribosomal scanning and start codon recognition0.95
    Translation initiation complex formation0.87
    3Metabolism of mRNA
    Metabolism of mRNA0.92
    Metabolism of RNA0.92
    4Generic Transcription Pathway
    Gene Expression0.47
    5Asparagine N-linked glycosylation
    Metabolism of proteins0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPS14
        CFTR translational fidelity (class I mutations)

    1 BioSystems Pathway for RPS14
        Cytoplasmic Ribosomal Proteins

    5/27        Reactome Pathways for RPS14 (see all 27)
        Formation of the ternary complex, and subsequently, the 43S complex
    Nonsense Mediated Decay Independent of the Exon Junction Complex
    Nonsense-Mediated Decay
    Translation
    SRP-dependent cotranslational protein targeting to membrane


    1         Kegg Pathway  (Kegg details for RPS14):
        Ribosome


    RPS14 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPS14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/951 Interacting proteins for RPS14 (P622631, 2, 3 ENSP000003110284) via UniProtKB, MINT, STRING, and/or I2D (see all 951)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AK6Q9Y3D82, 3MINT-67115 I2D: score=8 MINT-7945693 MINT-2862730 I2D: score=6 
    RPS16P622492, 3, ENSP000002514534MINT-6542674 MINT-8044065 MINT-8044024 I2D: score=1 STRING: ENSP00000251453
    RPL8P629172, 3, ENSP000002625844MINT-6542674 MINT-7945693 I2D: score=5 STRING: ENSP00000262584
    RPS3P233962, 3, ENSP000002785724MINT-6542674 MINT-7945693 I2D: score=4 STRING: ENSP00000278572
    RPL13P263732, 3, ENSP000003078894MINT-6542674 MINT-7945693 I2D: score=2 STRING: ENSP00000307889
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000028ribosomal small subunit assembly ISS--
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA7867928
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--

    RPS14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RPS14 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RPS14 (RS14)

    1 Novoseek inferred chemical compound relationship for RPS14 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    succinate 51.6 1 10799306 (1)

    Search CenterWatch for drugs/clinical trials and news about RPS14 / RS14

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RPS14 gene (3 alternative transcripts): 
    NM_001025070.1  NM_001025071.1  NM_005617.3  

    Unigene Cluster for RPS14:

    Ribosomal protein S14
    Hs.744846  [show with all ESTs]
    Unigene Representative Sequence: BC110792
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000401695 ENST00000521466 ENST00000518139 ENST00000312037 ENST00000519690
    ENST00000519855 ENST00000407193(uc003lsh.3 uc003lsi.3 uc003lsj.3)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK312179.1 BC001126.1 BC003401.1 BC006784.1 BC020515.1 BC091474.1 BC110792.1 

    24/56 DOTS entries (see all 56):

    DT.91824219  DT.92029839  DT.92464087  DT.95321325  DT.100043359  DT.91946899  DT.101986445  DT.97773928 
    DT.100059870  DT.100723785  DT.100771828  DT.100723794  DT.120888273  DT.95187159  DT.120888390  DT.100723797 
    DT.95314642  DT.100723792  DT.100723787  DT.95085884  DT.121421130  DT.97864661  DT.95258436  DT.95321482 

    24/2107 AceView cDNA sequences (see all 2107):

    AI092022 BQ065125 BE785544 BQ889765 AA316192 BI914912 C04940 BG899272 
    T73722 T61653 BU195370 BQ637534 CR592161 BU507437 CR596265 BU957524 
    BE901803 CB122694 BG109960 BM709774 AA308479 AI817429 BF311910 AJ573166 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RPS14    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
    SP1:                          -                       -               
    SP2:        -     -           -                                       
    SP3:                          -                                       
    SP4:                                                                  
    SP5:                                                                  


    ECgene alternative splicing isoforms for RPS14

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPS14 expression in normal human tissues (normalized intensities)      RPS14 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAACTGTTT
    RPS14 Expression
    About this image


    RPS14 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/31 selected tissues (see all 31) fully expand
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Epithelium (Reproductive System)    fully expand to see all 5 entries
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             rectum ; glandular cells   

    See RPS14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPS14

    SOURCE GeneReport for Unigene cluster: Hs.744846
        SABiosciences Custom PCR Arrays for RPS14
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPS14 gene from 10/30 species (see all 30)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rps141 , 5 ribosomal protein S141, 5 92.05(n)1
    100(a)1
      18 (34.40 cM)5
    200441  NM_020600.41  NP_065625.21 
     607745105 
    chicken
    (Gallus gallus)
    Aves RPS141 ribosomal protein S14 86.98(n)
    100(a)
      416275  NM_001030619.1  NP_001025790.1 
    lizard
    (Anolis carolinensis)
    Reptilia RPS146
    Uncharacterized protein
    89(a)
    1 ↔ 1
    2(138802911-138845064)
    African clawed frog
    (Xenopus laevis)
    Amphibia rps14-prov2 ribosomal protein S14 84.6(n)    BC041512.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa92e082 wufa92e08 83.51(n)   336687  BC059561.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RpS14b3
    RpS14a1
    protein biosynthesis structural
    constituent of ribosome less3
    Ribosomal protein S14a1
    85(a)
    (best of 2)3
    73.07(n)1
    86.75(a)1
      472181  NM_080145.41  NP_524884.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rps-141 , 3 Ribosomal protein S143
    Protein RPS-141
    85(a)3
    71.96(n)1
    86.75(a)1
      III(7250683-7251633)3
    1760061  NM_066171.51  NP_498572.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPS14A(YCR031C)4
    RPS14A1
    Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Bp and similar to E. coli S11 and rat S14 ribosomal proteins less4
    Rps14ap1
    69.19(n)1
    82.58(a)1
      3(178220-177500)4
    8503971, 4  NP_009960.21, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G115101 40S ribosomal protein S14-2 72.89(n)
    86.67(a)
      820324  NM_111984.4  NP_187758.1 
    rice
    (Oryza sativa)
    Liliopsida Os.78762 Oryza sativa (japonica cultivar-group) cDNA clone001-008-D11, full insert sequence less 78.36(n)    AK058907.1 


    ENSEMBL Gene Tree for RPS14 (if available)
    TreeFam Gene Tree for RPS14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPS14 gene
    1 SIMAP similar gene for RPS14 using alignment to 4 protein entries:     RS14_HUMAN (see all proteins):
    LOC401404

    RPS14 for paralogs           About GeneDecksing


    5/12 Pseudogenes.org Pseudogenes for RPS14 (see all 12)
    PGOHUM00000256785 PGOHUM00000244405 PGOHUM00000244627 PGOHUM00000245097 PGOHUM00000240255


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/202 SNPs in RPS14 are shown (see all 202)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs25453471,2
    C,F,A,H--149823394(-) CAGATC/TTTGGA 3 -- ds500123Minor allele frequency- T:0.10NS EA NA WA 2914
    rs1858041841,2
    --149823479(+) CCCACA/GTGTGT 3 -- ds50010--------
    rs1150078641,2
    F--149823501(+) ATGGGT/CCTGGA 3 -- ds50011Minor allele frequency- C:0.03WA 118
    rs1481573661,2
    --149823617(+) TCCAAC/TGCCTT 3 -- ds50010--------
    rs1410546181,2
    --149823624(+) CCTTGA/GTCTGC 3 -- ds50010--------
    rs1165754781,2
    C,F--149823657(+) ATGCCG/ACAAGT 3 -- ds50011Minor allele frequency- A:0.07WA 118
    rs2015548961,2
    --149823715(+) AGGCT-/CCTTTC 3 -- ds50010--------
    rs341193731,2
    C--149823717(+) GCTCCT/-TTCTC 3 -- ds50012Minor allele frequency- -:0.26NA NS 152
    rs1178864631,2
    F--149823746(+) GGAAGA/GAATCA 3 -- ds50011Minor allele frequency- G:0.03EA 120
    rs20708441,2
    C,F,O,A,H--149823785(-) TCCAGC/TCTTCT 3 -- ds5001 ese3 trp328Minor allele frequency- T:0.21EA NA NS CSA WA 4112

    HapMap Linkage Disequilibrium report for RPS14 (149822753 - 149829319 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RPS14:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv1862e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 130620   
    OMIM disorders: 153550  
    12 diseases for RPS14:    About MalaCards
    macrocytic anemia, refractory, due to 5q deletion, somatic    chromosome 5q deletion    macrocytic anemia    cartilage-hair hypoplasia
    diastrophic dysplasia    diamond-blackfan anemia    thrombocytopenia    anemia
    myelodysplastic syndromes    influenza    pneumonia    breast cancer

    4 diseases from the University of Copenhagen DISEASES database for RPS14:
    Treacher Collins syndrome     Bone marrow disease     Anemia     Diastrophic dysplasia

    RPS14 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RPS14
    Human Genome Epidemiology (HuGE) Navigator: RPS14 (3 documents)

    Export disorders for RPS14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPS14 gene, integrated from 9 sources (see all 92):
    (articles sorted by number of sources associating them with RPS14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Fine-structure map of the human ribosomal protein gene RPS14. (PubMed id 1549121)1, 2, 3, 9 Diaz J.-J. and Roufa D.J. (1992)
    2. Primary structure of human ribosomal protein S14 and the gene that encodes it. (PubMed id 3785212)1, 2, 3 Rhoads D.D.... Roufa D.J. (1986)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. Diamond-Blackfan anemia: genotype-phenotype correlati ons in Italian patients with RPL5 and RPL11 mutations. (PubMed id 19773262)1, 4 Quarello P....Ramenghi U. (2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699)1, 2 Vladimirov S.N.... Otto A. (1996)
    7. Homologous ribosomal proteins in bacteria, yeast, and humans. (PubMed id 3529092)1, 2 Chen I.-T.... Roufa D.J. (1986)
    8. Regulation of human RPS14 transcription by intronic antisense RNAs and ribosomal protein S14. (PubMed id 7867928)1, 9 Tasheva E.S. and Roufa D.J. (1995)
    9. Low RPS14 expression is common in myelodysplastic syn dromes without 5q- aberration and defines a subgroup of patients with prolonged survival. (PubMed id 19794090)1, 9 Czibere A....Germing U. (2009)
    10. Functional analysis of human RPS14 null alleles. (PubMed id 9152021)1, 9 Martin-Nieto J. and Roufa D.J. (1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6208 HGNC: 10387 AceView: RPS14 Ensembl:ENSG00000164587 euGenes: HUgn6208
    ECgene: RPS14 Kegg: 6208 H-InvDB: RPS14

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPS14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RPS14 gene:
    Search GeneIP for patents involving RPS14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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