Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RPS14 Gene

Aliases for RPS14 Gene

  • Ribosomal Protein S14 2 3 5
  • Small Ribosomal Subunit Protein US11 3 4
  • 40S Ribosomal Protein S14 2 3
  • Emetine Resistance 2 3
  • EMTB 3
  • S14 3

External Ids for RPS14 Gene

Previous GeneCards Identifiers for RPS14 Gene

  • GC05M149892
  • GC05M150420
  • GC05M149805
  • GC05M149852
  • GC05M149803
  • GC05M144971

Summaries for RPS14 Gene

Entrez Gene Summary for RPS14 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S11P family of ribosomal proteins. It is located in the cytoplasm. Transcript variants utilizing alternative transcription initiation sites have been described in the literature. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. In Chinese hamster ovary cells, mutations in this gene can lead to resistance to emetine, a protein synthesis inhibitor. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS14 Gene

RPS14 (Ribosomal Protein S14) is a Protein Coding gene. Diseases associated with RPS14 include Macrocytic Anemia, Refractory, Due To 5Q Deletion, Somatic and Diamond-Blackfan Anemia. Among its related pathways are Viral mRNA Translation and Metabolism. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPS14 Gene

Additional gene information for RPS14 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS14 Gene

Genomics for RPS14 Gene

Regulatory Elements for RPS14 Gene

Enhancers for RPS14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H150404 1.7 FANTOM5 ENCODE dbSUPER 17.3 +39.0 39046 13 HDGF PKNOX1 ATF1 MLX SIN3A NSD2 YBX1 BRCA1 YY1 ZNF121 TCOF1 RPS14 HMGXB3 CD74 CAMK2A ZNF300P1 RBM22 SYNPO DCTN4 ZNF300
GH05H150496 1.6 Ensembl ENCODE dbSUPER 18 -58.3 -58304 24 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 NDST1 TCOF1 NDST1-AS1 RPS14 HMGXB3 SYNPO ENSG00000253852 RBM22 MYOZ3 ENSG00000250309
GH05H150263 1.5 Ensembl ENCODE dbSUPER 18.7 +185.5 185466 1 HDGF ZNF133 SIN3A YBX1 GLI4 ZNF2 ZBTB7B TCF12 ZNF143 FOS TCOF1 HMGXB3 RPL7P1 ZNF300 ZNF300P1 RPS14 ENSG00000248696 PCYOX1L CARMN TIGD6
GH05H150476 1.4 Ensembl ENCODE dbSUPER 17.4 -27.7 -27716 1 HDAC1 PKNOX1 ZSCAN4 BMI1 NFXL1 TCF12 ZNF766 ATF7 ETV6 RUNX3 NDST1 RPS14 SYNPO ENSG00000253852 GC05P150482
GH05H149956 2 FANTOM5 Ensembl ENCODE dbSUPER 11.4 +490.1 490107 6 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 ZBTB7B YY1 HMGXB3 TCOF1 ZNF300 ZNF300P1 TIGD6 RPL7P1 CSNK1A1 RPS20P4 PDGFRB SLC26A2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPS14 on UCSC Golden Path with GeneCards custom track

Promoters for RPS14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000188977 356 2000 DMAP1 YY1 SLC30A9 ZNF143 SP3 MEF2D ZNF610 GLIS1 RCOR2 NBN

Genomic Location for RPS14 Gene

Chromosome:
5
Start:
150,443,190 bp from pter
End:
150,449,756 bp from pter
Size:
6,567 bases
Orientation:
Minus strand

Genomic View for RPS14 Gene

Genes around RPS14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS14 Gene

Proteins for RPS14 Gene

  • Protein details for RPS14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62263-RS14_HUMAN
    Recommended name:
    40S ribosomal protein S14
    Protein Accession:
    P62263
    Secondary Accessions:
    • B2R5G5
    • D3DQG5
    • P06366
    • Q5BJI0

    Protein attributes for RPS14 Gene

    Size:
    151 amino acids
    Molecular mass:
    16273 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS14 Gene

neXtProt entry for RPS14 Gene

Post-translational modifications for RPS14 Gene

  • Ubiquitination at isoforms=63, Lys86, Lys96, and Lys106
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPS14 Gene

Domains & Families for RPS14 Gene

Gene Families for RPS14 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPS14 Gene

Suggested Antigen Peptide Sequences for RPS14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62263

UniProtKB/Swiss-Prot:

RS14_HUMAN :
  • Belongs to the universal ribosomal protein uS11 family.
Family:
  • Belongs to the universal ribosomal protein uS11 family.
genes like me logo Genes that share domains with RPS14: view

Function for RPS14 Gene

Molecular function for RPS14 Gene

GENATLAS Biochemistry:
40S ribosomal protein S14,16kDa

Phenotypes From GWAS Catalog for RPS14 Gene

Gene Ontology (GO) - Molecular Function for RPS14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding ISS --
GO:0003735 structural constituent of ribosome IBA --
GO:0005515 protein binding IPI 24965446
GO:0045182 translation regulator activity IMP 3683397
GO:0048027 mRNA 5-UTR binding IDA 7867928
genes like me logo Genes that share ontologies with RPS14: view
genes like me logo Genes that share phenotypes with RPS14: view

Human Phenotype Ontology for RPS14 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RPS14
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS14 Gene

Localization for RPS14 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS14 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
mitochondrion 3
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Endoplasmic reticulum (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPS14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA 9152021
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with RPS14: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS14 Gene

Pathways & Interactions for RPS14 Gene

SuperPathways for RPS14 Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
.55
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 rRNA processing in the nucleus and cytosol
4 Influenza Viral RNA Transcription and Replication
5 HIV Life Cycle
.45
genes like me logo Genes that share pathways with RPS14: view

Gene Ontology (GO) - Biological Process for RPS14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000028 ribosomal small subunit assembly ISS --
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 7867928
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0006364 rRNA processing TAS --
genes like me logo Genes that share ontologies with RPS14: view

No data available for SIGNOR curated interactions for RPS14 Gene

Drugs & Compounds for RPS14 Gene

(1) Additional Compounds for RPS14 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RPS14: view

Transcripts for RPS14 Gene

Unigene Clusters for RPS14 Gene

Ribosomal protein S14:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RPS14
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RPS14 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1: - -
SP2: - - -
SP3: -
SP4:
SP5:

Relevant External Links for RPS14 Gene

GeneLoc Exon Structure for
RPS14
ECgene alternative splicing isoforms for
RPS14

Expression for RPS14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPS14 Gene

Protein differential expression in normal tissues from HIPED for RPS14 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPS14 Gene



Protein tissue co-expression partners for RPS14 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS14 Gene:

RPS14

SOURCE GeneReport for Unigene cluster for RPS14 Gene:

Hs.744846

Evidence on tissue expression from TISSUES for RPS14 Gene

  • Blood(4.8)
  • Liver(4.8)
  • Skin(4.8)
  • Lung(4.7)
  • Nervous system(4.6)
  • Pancreas(4.3)
  • Eye(4.2)
  • Intestine(4.2)
  • Muscle(3.6)
  • Bone marrow(3.4)
  • Bone(3.1)
  • Heart(3)
  • Kidney(2.9)
  • Lymph node(2.8)
  • Spleen(2.6)
  • Stomach(2.6)
  • Thyroid gland(2.6)
  • Adrenal gland(2.5)
  • Gall bladder(2.5)

Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS14 Gene

Germ Layers:
  • mesoderm
Systems:
  • cardiovascular
Organs:
General:
  • blood
  • bone marrow
  • coagulation system
  • red blood cell
  • white blood cell
genes like me logo Genes that share expression patterns with RPS14: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS14 Gene

Orthologs for RPS14 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS14 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia RPS14 34
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPS14 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPS14 34 33
  • 99.78 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RPS14 33 34
  • 93.02 (n)
-- 34
  • 86 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RPS14 34 33
  • 92.72 (n)
OneToMany
-- 34
  • 88 (a)
OneToMany
-- 34
  • 81 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rps14 33
  • 92.27 (n)
mouse
(Mus musculus)
Mammalia Rps14 16 34 33
  • 92.05 (n)
chicken
(Gallus gallus)
Aves RPS14 34 33
  • 86.98 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPS14 34
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC549476 33
  • 84.55 (n)
Str.5998 33
African clawed frog
(Xenopus laevis)
Amphibia rps14-prov 33
zebrafish
(Danio rerio)
Actinopterygii rps14 34
  • 99 (a)
OneToOne
wufa92e08 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4262 33
fruit fly
(Drosophila melanogaster)
Insecta RpS14a 35 34
  • 85 (a)
RpS14b 35 34
  • 85 (a)
worm
(Caenorhabditis elegans)
Secernentea rps-14 33 34 35
  • 71.43 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS14B 34
  • 79 (a)
OneToMany
RPS14A 34 36 33
  • 70.25 (n)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B07623g 33
  • 69.15 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL152W 33
  • 68.6 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G11510 33
  • 73.86 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.965 33
rice
(Oryza sativa)
Liliopsida Os02g0162500 33
  • 74.1 (n)
Os.7876 33
barley
(Hordeum vulgare)
Liliopsida Hv.3897 33
corn
(Zea mays)
Liliopsida Zm.6030 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4503 34
  • 89 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU07830 33
  • 72.66 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps1402 33
  • 71.2 (n)
Species where no ortholog for RPS14 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS14 Gene

ENSEMBL:
Gene Tree for RPS14 (if available)
TreeFam:
Gene Tree for RPS14 (if available)

Paralogs for RPS14 Gene

(1) SIMAP similar genes for RPS14 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RPS14: view

No data available for Paralogs for RPS14 Gene

Variants for RPS14 Gene

Sequence variations from dbSNP and Humsavar for RPS14 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000272958 -- 150,445,806(+) CAGAC(A/G)GGGCT intron-variant
rs1000775775 -- 150,449,969(+) ACACC(C/G)GCGGG upstream-variant-2KB
rs1001394383 -- 150,444,788(+) TGGGA(C/G)ACTGA intron-variant, utr-variant-3-prime
rs1001708048 -- 150,449,242(+) CTGCT(C/T)TCCTT intron-variant
rs1001976021 -- 150,450,601(+) CCTCC(C/T)AAGTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPS14 Gene

Variant ID Type Subtype PubMed ID
esv2759386 CNV loss 17122850
nsv980744 CNV duplication 23825009

Variation tolerance for RPS14 Gene

Residual Variation Intolerance Score: 48.7% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPS14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS14 Gene

Disorders for RPS14 Gene

MalaCards: The human disease database

(3) MalaCards diseases for RPS14 Gene - From: OMIM, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
macrocytic anemia, refractory, due to 5q deletion, somatic
  • chromosome 5q deletion syndrome
diamond-blackfan anemia
  • diamond-blackfan anemia 1
retinitis pigmentosa 14
  • rp14
- elite association - COSMIC cancer census association via MalaCards
Search RPS14 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RPS14

Genetic Association Database (GAD)
RPS14
Human Genome Epidemiology (HuGE) Navigator
RPS14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPS14
genes like me logo Genes that share disorders with RPS14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS14 Gene

Publications for RPS14 Gene

  1. Fine-structure map of the human ribosomal protein gene RPS14. (PMID: 1549121) Diaz JJ … Roufa DJ (Molecular and cellular biology 1992) 2 3 4 22 60
  2. Primary structure of human ribosomal protein S14 and the gene that encodes it. (PMID: 3785212) Rhoads DD … Roufa DJ (Molecular and cellular biology 1986) 2 3 4 60
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  4. Diamond-Blackfan anemia: genotype-phenotype correlations in Italian patients with RPL5 and RPL11 mutations. (PMID: 19773262) Quarello P … Ramenghi U (Haematologica 2010) 3 45 60
  5. Low RPS14 expression is common in myelodysplastic syndromes without 5q- aberration and defines a subgroup of patients with prolonged survival. (PMID: 19794090) Czibere A … Germing U (Haematologica 2009) 3 22 60

Products for RPS14 Gene

Sources for RPS14 Gene

Content
Loading form....