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Aliases for RPS14 Gene

Aliases for RPS14 Gene

  • Ribosomal Protein S14 2 3
  • 40S Ribosomal Protein S14 2 3
  • Emetine Resistance 2 3
  • EMTB 3 6
  • S14 3

External Ids for RPS14 Gene

Previous GeneCards Identifiers for RPS14 Gene

  • GC05M149892
  • GC05M150420
  • GC05M149805
  • GC05M149852
  • GC05M149803
  • GC05M144971

Summaries for RPS14 Gene

Entrez Gene Summary for RPS14 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S11P family of ribosomal proteins. It is located in the cytoplasm. Transcript variants utilizing alternative transcription initiation sites have been described in the literature. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. In Chinese hamster ovary cells, mutations in this gene can lead to resistance to emetine, a protein synthesis inhibitor. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS14 Gene

RPS14 (Ribosomal Protein S14) is a Protein Coding gene. Diseases associated with RPS14 include macrocytic anemia, refractory, due to 5q deletion, somatic and macrocytic anemia. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include RNA binding and translation regulator activity.

Gene Wiki entry for RPS14 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS14 Gene

Genomics for RPS14 Gene

Regulatory Elements for RPS14 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RPS14 Gene

Start:
150,443,190 bp from pter
End:
150,449,786 bp from pter
Size:
6,597 bases
Orientation:
Minus strand

Genomic View for RPS14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPS14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS14 Gene

Proteins for RPS14 Gene

  • Protein details for RPS14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62263-RS14_HUMAN
    Recommended name:
    40S ribosomal protein S14
    Protein Accession:
    P62263
    Secondary Accessions:
    • B2R5G5
    • D3DQG5
    • P06366
    • Q5BJI0

    Protein attributes for RPS14 Gene

    Size:
    151 amino acids
    Molecular mass:
    16273 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS14 Gene

neXtProt entry for RPS14 Gene

Proteomics data for RPS14 Gene at MOPED

Post-translational modifications for RPS14 Gene

  • Ubiquitination at Lys63, Lys86, Lys96, and Lys106
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS14 Gene

Antibody Products

No data available for DME Specific Peptides for RPS14 Gene

Domains for RPS14 Gene

Gene Families for RPS14 Gene

HGNC:
  • RPS :S ribosomal proteins

Protein Domains for RPS14 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RPS14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62263

UniProtKB/Swiss-Prot:

RS14_HUMAN :
  • P62263
Family:
  • Belongs to the ribosomal protein S11P family.
genes like me logo Genes that share domains with RPS14: view

Function for RPS14 Gene

Molecular function for RPS14 Gene

GENATLAS Biochemistry:
40S ribosomal protein S14,16kDa

Gene Ontology (GO) - Molecular Function for RPS14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding ISS --
GO:0003735 structural constituent of ribosome IEA --
GO:0005515 protein binding IPI 25416956
GO:0044822 poly(A) RNA binding IDA 22681889
GO:0045182 translation regulator activity IMP 3683397
genes like me logo Genes that share ontologies with RPS14: view
genes like me logo Genes that share phenotypes with RPS14: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPS14

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPS14 Gene

Localization for RPS14 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS14 Gene COMPARTMENTS Subcellular localization image for RPS14 gene
Compartment Confidence
cytosol 5
mitochondrion 5
nucleus 5
chloroplast 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for RPS14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA 9152021
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome --
genes like me logo Genes that share ontologies with RPS14: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS14 Gene

Pathways for RPS14 Gene

SuperPathways for RPS14 Gene

Superpath Contained pathways
1 Influenza Viral RNA Transcription and Replication
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 CFTR translational fidelity (class I mutations)
.54
4 Disease
5 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
genes like me logo Genes that share pathways with RPS14: view

Pathways by source for RPS14 Gene

1 KEGG pathway for RPS14 Gene
1 GeneGo (Thomson Reuters) pathway for RPS14 Gene

Gene Ontology (GO) - Biological Process for RPS14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000028 ribosomal small subunit assembly ISS --
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 7867928
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPS14: view

Compounds for RPS14 Gene

(1) Novoseek inferred chemical compound relationships for RPS14 Gene

Compound -log(P) Hits PubMed IDs
succinate 51.6 1
genes like me logo Genes that share compounds with RPS14: view

Transcripts for RPS14 Gene

Unigene Clusters for RPS14 Gene

Ribosomal protein S14:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPS14

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS14 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1: - -
SP2: - - -
SP3: -
SP4:
SP5:

Relevant External Links for RPS14 Gene

GeneLoc Exon Structure for
RPS14
ECgene alternative splicing isoforms for
RPS14

Expression for RPS14 Gene

mRNA expression in normal human tissues for RPS14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for RPS14 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (6.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS14 Gene

SOURCE GeneReport for Unigene cluster for RPS14 Gene Hs.744846

genes like me logo Genes that share expressions with RPS14: view

Expression partners for RPS14 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS14 Gene

Orthologs for RPS14 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS14 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPS14 35
  • 93.02 (n)
  • 100 (a)
-- 36
  • 86 (a)
OneToMany
RPS14 36
  • 85 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RPS14 35
  • 92.72 (n)
  • 100 (a)
-- 36
  • 81 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
RPS14 36
  • 71 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rps14 35
  • 92.05 (n)
  • 100 (a)
Rps14 16
Rps14 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPS14 35
  • 99.78 (n)
  • 100 (a)
RPS14 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rps14 35
  • 92.27 (n)
  • 99.34 (a)
oppossum
(Monodelphis domestica)
Mammalia RPS14 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPS14 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPS14 35
  • 86.98 (n)
  • 100 (a)
RPS14 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPS14 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC549476 35
  • 84.55 (n)
  • 100 (a)
Str.5998 35
African clawed frog
(Xenopus laevis)
Amphibia rps14-prov 35
zebrafish
(Danio rerio)
Actinopterygii wufa92e08 35
rps14 36
  • 99 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4262 35
fruit fly
(Drosophila melanogaster)
Insecta RpS14a 37
  • 85 (a)
RpS14b 37
  • 85 (a)
RpS14a 36
  • 87 (a)
OneToMany
RpS14b 36
  • 87 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rps-14 37
  • 85 (a)
rps-14 35
  • 71.43 (n)
  • 85.71 (a)
rps-14 36
  • 86 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL152W 35
  • 68.6 (n)
  • 80.99 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B07623g 35
  • 69.15 (n)
  • 81.82 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS14A 35
  • 70.25 (n)
  • 81.82 (a)
RPS14A 36
  • 80 (a)
OneToMany
RPS14B 36
  • 79 (a)
OneToMany
RPS14A 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G11510 35
  • 73.86 (n)
  • 85.61 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.965 35
barley
(Hordeum vulgare)
Liliopsida Hv.3897 35
rice
(Oryza sativa)
Liliopsida Os.7876 35
Os02g0162500 35
  • 74.1 (n)
  • 85.61 (a)
corn
(Zea mays)
Liliopsida Zm.6030 35
bread mold
(Neurospora crassa)
Ascomycetes NCU07830 35
  • 72.66 (n)
  • 86.33 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps1402 35
  • 71.2 (n)
  • 82.4 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4503 36
  • 89 (a)
OneToOne
Species with no ortholog for RPS14:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS14 Gene

ENSEMBL:
Gene Tree for RPS14 (if available)
TreeFam:
Gene Tree for RPS14 (if available)

Paralogs for RPS14 Gene

Selected SIMAP similar genes for RPS14 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RPS14: view

No data available for Paralogs for RPS14 Gene

Variants for RPS14 Gene

Sequence variations from dbSNP and Humsavar for RPS14 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs4841 -- 150,446,963(-) CCCAG(A/C/G)GAAAC synonymous-codon, missense, reference
rs2070840 -- 150,445,596(-) CCCCC(C/G/T)TCTAG intron-variant, reference, missense
rs2070841 -- 150,444,908(-) TCTAC(C/T)GAGTA intron-variant, downstream-variant-500B
rs2070842 -- 150,444,660(-) GTCTA(A/G)AAGGG intron-variant, downstream-variant-500B
rs2070843 -- 150,444,449(-) AGCAG(G/T)ATCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPS14 Gene

Variant ID Type Subtype PubMed ID
dgv1862e1 CNV Complex 17122850

Relevant External Links for RPS14 Gene

HapMap Linkage Disequilibrium report
RPS14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS14 Gene

Disorders for RPS14 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for RPS14 Gene in MalaCards »

(2) Diseases for RPS14 Gene including...

(1) OMIM Diseases for RPS14 Gene (130620)

(4) University of Copenhagen DISEASES for RPS14 Gene

Relevant External Links for RPS14

Genetic Association Database (GAD)
RPS14
Human Genome Epidemiology (HuGE) Navigator
RPS14
genes like me logo Genes that share disorders with RPS14: view

No data available for UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for RPS14 Gene

Publications for RPS14 Gene

  1. Fine-structure map of the human ribosomal protein gene RPS14. (PMID: 1549121) Diaz J.-J. … Roufa D.J. (Mol. Cell. Biol. 1992) 2 3 4 23
  2. Primary structure of human ribosomal protein S14 and the gene that encodes it. (PMID: 3785212) Rhoads D.D. … Roufa D.J. (Mol. Cell. Biol. 1986) 2 3 4
  3. Regulation of human RPS14 transcription by intronic antisense RNAs and ribosomal protein S14. (PMID: 7867928) Tasheva E.S. … Roufa D.J. (Genes Dev. 1995) 3 23
  4. Low RPS14 expression is common in myelodysplastic syndromes without 5q- aberration and defines a subgroup of patients with prolonged survival. (PMID: 19794090) Czibere A. … Germing U. (Haematologica 2009) 3 23
  5. Functional analysis of human RPS14 null alleles. (PMID: 9152021) Martin-Nieto J. … Roufa D.J. (J. Cell. Sci. 1997) 3 23

Products for RPS14 Gene

Sources for RPS14 Gene

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