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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RPS13 Gene

protein-coding GIFtS: 60
GCID: GC11M017055

ribosomal protein S13

Explore 2 diseases affiliated with
RPS13 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ribosomal Protein S13¹ ²
S13¹ ²
40S Ribosomal Protein S13²

External Ids:	HGNC: 10386¹	Entrez Gene: 6207²	Ensembl: ENSG00000110700⁷	OMIM: 180476⁵	UniProtKB: P62277³

Export aliases for RPS13 gene to outside databases

Previous GC identifers: GC11M018166 GC11M018039 GC11M017135 GC11M017060 GC11M017054 GC11M016780

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RPS13:

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.

Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene

encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S15P family of

ribosomal proteins. It is located in the cytoplasm. The protein has been shown to bind to the 5.8S rRNA in rat. The

gene product of the E. coli ortholog (ribosomal protein S15) functions at early steps in ribosome assembly. This gene

is co-transcribed with two U14 small nucleolar RNA genes, which are located in its third and fifth introns. As is

typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through

the genome. (provided by RefSeq, Jul 2008)

Gene Wiki entry for RPS13

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RPS13 gene promoter:
Nkx3-1 AP-2rep p53 AP-1 Nkx3-1 v1 YY1 GATA-1 Nkx3-1 v2 Ik-2 Nkx3-1 v3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RPS13 promoter sequence

Search SABiosciences Chromatin IP Primers for RPS13

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS13

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15 Ensembl cytogenetic band: 11p15.1 HGNC cytogenetic band: 11p

RPS13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS13 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M017055: view genomic region (about GC identifiers)

Start:	17,095,936 bp from pter	End:	17,099,334 bp from pter
Size:	3,399 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RS13_HUMAN, P62277 (See protein sequence)

Recommended Name: 40S ribosomal protein S13

Size: 151 amino acids; 17222 Da

Secondary accessions: B2R549 P19116 Q02546 Q29200 Q498Y0

Explore the universe of human proteins at neXtProt for RPS13: NX_P62277

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P62277

RPS13 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001008.1

ENSEMBL proteins:

ENSP00000228140 ENSP00000435777 ENSP00000432096

Reactome Protein details: P62277
Human Recombinant Protein Products:

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	Uscn Proteins for RPS13

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	17881366
GO:0005730	nucleolus	IDA	17881366
GO:0005829	cytosol	TAS	--
GO:0005840	ribosome	NAS	8332508
GO:0022627	cytosolic small ribosomal subunit	IDA	8706699

RPS13 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for RPS13

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RPS13 for domains About GeneDecksing

4 InterPro domains/families:

IPR023029 Ribosomal_S15P

IPR012606 Ribosomal_S13/S15_N

IPR000589 Ribosomal_S15

IPR009068 S15_NS1_RNA-bd

Graphical View of Domain Structure for InterPro Entry P62277

ProtoNet protein and cluster: P62277

1 Blocks protein family: IPB012606 Ribosomal S13S15 N-terminal

UniProtKB/Swiss-Prot: RS13_HUMAN, P62277

Similarity: Belongs to the ribosomal protein S15P family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

Genatlas biochemistry entry for RPS13:

60S ribosomal protein S13

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPS13
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Gene Editing
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In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RPS13

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003729	mRNA binding	IDA	17881366
GO:0003735	structural constituent of ribosome	IEA	--
GO:0005515	protein binding	IPI	12054647

RPS13 for ontologies About GeneDecksing

7 GenomeRNAi human phenotypes for RPS13:

Decreased Hepatitis C virus re	Decreased cell number	Decreased viability	Decreased viability of wild-ty
Increased cell number in G2M,	Nuclear 40S maturation defects	Nucleolar pre-40S maturation d

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Synthesis of PB1-F2

8/26 pathways (see all 26)
Viral Protein Synthesis	1.00	Cytoplasmic Ribosomal Proteins	0.86
Viral mRNA Translation	1.00	CFTR translational fidelity (class I mutations)	0.83
Influenza Viral RNA Transcription and Replication	1.00	SMG6 Cleaves mRNA with Premature Termination Codon	0.80
Synthesis of nascent polypeptide containing signal sequence	1.00	L13a-mediated translational silencing of Ceruloplasmin expression	0.79

Translation initiation complex formation

	Translation initiation complex formation	1.00			Ribosomal scanning and start codon recognition	0.96
	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	0.98			Formation of the ternary complex, and subsequently, the 43S complex	0.87

Metabolism of mRNA

Metabolism of mRNA

1.00

Metabolism of RNA

0.92

Disease

Disease

1.00

TNF-alpha/NF-kB Signaling Pathway

TNF-alpha/NF-kB Signaling Pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 GeneGo (Thomson Reuters) Pathway for RPS13

CFTR translational fidelity (class I mutations)

2 BioSystems Pathways for RPS13

	Cytoplasmic Ribosomal Proteins
	TNF-alpha/NF-kB Signaling Pathway

5/32 Reactome Pathways for RPS13 (see all 32)

	Formation of a pool of free 40S subunits
	Synthesis of PB1-F2
	SMG6 Cleaves mRNA with Premature Termination Codon
	Influenza Life Cycle
	Viral mRNA Translation

1 Kegg Pathway (Kegg details for RPS13):

Ribosome

RPS13 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RPS13

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/953 Interacting proteins for RPS13 (P62277^{1, 2, 3} ENSP00000228140⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 953)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RPL8	P62917²^,³, ENSP00000262584⁴	MINT-6542674 MINT-6489539 MINT-6488791 I2D: score=2 STRING: ENSP00000262584
RPL11	P62913²^,³, ENSP00000363676⁴	MINT-6542674 MINT-6489539 MINT-6488791 I2D: score=1 STRING: ENSP00000363676
RPL12	P30050²^,³, ENSP00000354739⁴	MINT-6542674 MINT-6489539 MINT-6488791 I2D: score=1 STRING: ENSP00000354739
RPL13	P26373²^,³, ENSP00000307889⁴	MINT-6542674 MINT-7947479 MINT-6488791 I2D: score=1 STRING: ENSP00000307889
RPL26	P61254²^,³, ENSP00000293842⁴	MINT-6542674 MINT-6489539 MINT-6488791 I2D: score=1 STRING: ENSP00000293842

About this table

Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS	--
GO:0006412	translation	TAS	--
GO:0006413	translational initiation	TAS	--
GO:0006414	translational elongation	TAS	--
GO:0006415	translational termination	TAS	--

RPS13 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RPS13
Search CenterWatch for drugs/clinical trials and news about RPS13 / RS13

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RPS13 gene:

NM_001017.2

Unigene Cluster for RPS13:

Ribosomal protein S13

Hs.446588 [show with all ESTs]

Unigene Representative Sequence: BE621497

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000531008 ENST00000531908 ENST00000228140 ENST00000526895 ENST00000525634(uc001mmp.3)

ENST00000525828 ENST00000533969 ENST00000527571 ENST00000534329 ENST00000528074

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RPS13
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		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPS13 (see all 7) OriGene shRNA RFP: RPS13 OriGene siRNA: RPS13
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS13

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS13

Additional cDNA sequence:

AK312060.1 BC000475.1 BC006772.1 BC029732.1 BC066322.1 BC100032.1 L01124.1 L05090.1

X79239.1

24/45 DOTS entries (see all 45):

DT.100034195 DT.91780893 DT.91780905 DT.100060141 DT.95377158 DT.97814138 DT.100689183 DT.120736380

DT.100689171 DT.120736387 DT.100689181 DT.120736393 DT.100060137 DT.121431383 DT.100689168 DT.100689186

DT.120736385 DT.120736420 DT.121431378 DT.421641 DT.85101328 DT.91780895 DT.100689175 DT.120736415

24/1408 AceView cDNA sequences (see all 1408):

BM841621 BQ277838 T69927 AA381436 BM006169 CN485114 AI124967 NR_001452

F21917 CD677360 BG686936 CA843734 BM758837 AA317959 AW474405 CB113644

AV712079 AA353627 BQ353162 BF032207 BM817860 BG289197 BG474759 H80045

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for RPS13 About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	·	3c	·	3d	^	4	^	5	^	6
SP1:
SP2:													-		-		-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for RPS13

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RPS13 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGTTGCACA

About this image

RPS13 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Primary Follicle

Primary Oocyte

Female Gametocytes, Germ Cells

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RPS13 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RPS13

SOURCE GeneReport for Unigene cluster: Hs.446588

SABiosciences Custom PCR Arrays for RPS13

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS13

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RPS13

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes and Archea.

Orthologs for RPS13 gene from 38 species (see representative species ) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chimpanzee (Pan troglodytes)	Mammalia	RPS13¹	ribosomal protein S13	99.78(n) 100(a)		451051 XM_508306.4 XP_508306.1
mouse (Mus musculus)	Mammalia	Rps13^{1 , 5}	ribosomal protein S13^{1, 5}	86.98(n)¹ 100(a)¹		7 (61.61 cM)⁵ 68052¹ NM_026533.3¹ NP_080809.1¹ 116331507⁵
rat (Rattus norvegicus)	Mammalia	LOC684988¹	similar to ribosomal protein S13	87.2(n) 100(a)		684988 XM_001053043.2 XP_001053043.1
cow (Bos taurus)	Mammalia	RPS13¹	ribosomal protein S13	90.51(n) 100(a)		535668 NM_001025342.2 NP_001020513.1
dog (Canis familiaris)	Mammalia	RPS13¹	ribosomal protein S13	91.39(n) 100(a)		610820 XM_003432927.1 XP_003432975.1
oppossum (Monodelphis domestica)	Mammalia	RPS13⁶	Uncharacterized protein	99(a)	1 ↔ 1	5(244455828-244459910)
platypus (Ornithorhynchus anatinus)	Mammalia	RPS13⁶	Uncharacterized protein	99(a)	1 ↔ 1	Ultra270(431238-438477)
chicken (Gallus gallus)	Aves	RPS13¹	ribosomal protein S13	81.68(n) 100(a)		414782 NM_001001783.1 NP_001001783.1
lizard (Anolis carolinensis)	Reptilia	RPS13⁶	--	100(a)	1 ↔ 1	1(66624651-66629484)
African clawed frog (Xenopus laevis)	Amphibia	rps13-prov²	ribosomal protein S13	81.14(n)		BC056028.1
tropical clawed frog (Xenopus tropicalis)	Amphibia	137720651²	--	81.16(n)		137720651
zebrafish (Danio rerio)	Actinopterygii	57084826²	--	78.84(n)		57084826
rainbow trout (Oncorhynchus mykiss)	Actinopterygii	Omy.13839²	Oncorhynchus mykiss transcribed sequence with strong more	79.49(n)		CA361715.1
sea squirt (Ciona intestinalis)	Ascidiacea	Cin.14352²	Ciona intestinalis mRNA for putative 40S ribosomal more	75.06(n)		AJ297730.1
sea squirt (Ciona savignyi)	Ascidiacea	--	--	88(a)	1 ↔ 1	reftig_410(156994-159186)
sea urchin (Strongylocentrotus purpuratus)	Echinoidea	--	--	90(a)	1 ↔ 1	scaffold_4250(234-6574)
fruit fly (Drosophila melanogaster)	Insecta	RpS13^{1 , 3}	protein biosynthesis structural constituent of more³ Ribosomal protein S13¹	87(a)³ 71.08(n)¹ 87.42(a)¹		2 29B2³ 34149¹ NM_001038796.2¹ NP_001033885.1¹
mosquito (Anopheles gambiae)	Insecta	RS13_ANOGA¹	AGAP005947-PA	68.21(n) 84.11(a)		1276616 XM_315982.4 XP_315982.2
honey bee (Apis mellifera)	Insecta	--	--	89(a)	1 ↔ 1	GroupUn.6842(1788-3117)
worm (Caenorhabditis elegans)	Secernentea	rps-13^{1 , 3}	40S ribosomal protein S13³ Protein RPS-13¹	76(a)³ 68.43(n)¹ 76.16(a)¹		III(6445813-6446906)³ 175901¹ NM_065992.4¹ NP_498393.1¹
schistosome parasite (Schistosoma mansoni)	Trematoda	Smp_096750⁶	Expressed protein	83(a)	1 ↔ 1	Smp_scaff000596(125081-125689) Smp_096750
common water flea (Daphnia pulex)	Crustacea	--	--	91(a)	1 ↔ 1	scaffold_87(350958-352164)
Trichoplax (Trichoplax adhaerens)	Tricoplacia	--	--	85(a)	1 ↔ 1	scaffold_26(303531-305185)
sea anemone (Nematostella vectensis)	Anthozoa	--	--	91(a)	1 ↔ 1	scaffold_243(21620-24335) NEMVEDRAFT_v1g235818
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	RPS13(YDR064W)⁴	Protein component of the small (40S) ribosomal subunit; more	--		4(579458-580452) 851636 NP_010349.1
stem rust fungus (Puccinia graminis)	Pucciniomycetes	PGTG_11035⁶	40S ribosomal protein S13, variant	75(a)	1 ↔ 1
amoeba (Dictyostelium discoideum)	Dictyostelia	RPS13⁶	40S ribosomal protein S13	64(a)	1 ↔ 1	4(2127182-2127908)
malaria parasite (Plasmodium falciparum)	Aconoidasida	PF13_0316⁶	40S ribosomal protein S13, putative	66(a)	1 ↔ 1	13(2327407-2327862)
Chromalveolata (Phytophthora infestans)	Oomycota	PITG_20264⁶	40S ribosomal protein S13	77(a)	1 ↔ 1	supercont1.166(155785-156568)
thale cress (Arabidopsis thaliana)	eudicotyledons	ATRPS13A⁶ AT3G60770⁶	40S ribosomal protein S13-1	79(a) 78(a)	many → 1 many → 1	4(37084-38312) 3(22460189-22461779)
soybean (Glycine max)	eudicotyledons	46777354²	--	71.11(n)
Alicante grape (Vitis vinifera)	eudicotyledons	CF606621.1²	--	73.73(n)		CF606621.1
rice (Oryza sativa)	Liliopsida	Os.15168²	Oryza sativa (japonica cultivar-group) cDNA clone0 more	71.08(n)		AK059505.1
barley (Hordeum vulgare)	Liliopsida	BI948270.1²	--	73.11(n)		BI948270.1
corn (Zea mays)	Liliopsida	Zm.3223²	Z.mays S13 mRNA for cytoplasmic ribosomal protein S13	68.92(n)		X62455.1
wheat (Triticum aestivum)	Liliopsida	Ta.14203²	Triticum aestivum transcribed sequence with moderate more	72.89(n)		CD871296.1
green algae (Chlamydomonas reinhardtii)	Chlorophyceae	RPS13⁶	ribosomal protein S13	70(a)	1 ↔ 1	DS496117(1475081-1477163)
Archea (Pyrococcus horikoshii)	Thermococci	PH0058⁶	158aa long hypothetical 40S ribosomal protein S13	44(a)	1 ↔ 1	Chromosome(50393-50869)

Species with no ortholog for RPS13

ENSEMBL Gene Tree for RPS13 (if available)
TreeFam Gene Tree for RPS13 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for RPS13 gene

18/41 SIMAP similar genes for RPS13 using alignment to 3 protein entries: RS13_HUMAN (see all proteins) (see all similar genes):

RRM2B EIF3G LSM12 C12orf76 UBXN4 ADCK1

EIF3K DOCK8 FLJ00047 EEF1E1 GALK2 PFKFB3

C21orf37 DYNC2LI1 COQ5 NCKAP1L SH2B3 RHBG

RPS13 for paralogs About GeneDecksing

5/11 Pseudogenes.org Pseudogenes for RPS13 (see all 11)
PGOHUM00000246797 PGOHUM00000247118 PGOHUM00000244031 PGOHUM00000245058 PGOHUM00000239991

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs116962013^1,2		--	17095486(+)	`CCTCCA/GGTGAC`	1	--	ds500¹		1		NA	120
rs11024147^1,2	C,F,A,H,	--	17095565(+)	`ATTACT/GTTTGC`	1	--	ds500¹		10		NS EA WA CSA	786
rs16924899^1,2	C,F,H,	--	17095596(+)	`TCTGAT/CGCTAC`	1	--	ds500¹		27		NA NS EA CSA WA EU	3425
rs188247066^1,2		--	17095686(+)	`ATGACA/GCCAAA`	1	--	ds500¹		0	--	--	--	--
rs116849425^1,2	C,F,	--	17095699(+)	`AAACAC/AAAAGG`	1	--	ds500¹		1		EA	120
rs191783057^1,2	C,	--	17095934(+)	`AACATC/GCTTTT`	2	--	ds500¹		0	--	--	--	--
rs147452342^1,2	C,F,	--	17095967(+)	`TTGAGT/AACACA`	2	--	ut3¹ ds500¹		1		EU	1291
rs11024148^1,2	C,F,A,H,	--	17096059(+)	`ATACTG/AGTCCC`	2	--	int¹ ds500¹		27		NA NS EA WA CSA	2727
rs184095379^1,2		--	17096084(+)	`CAGAAG/TCTCCC`	2	--	ds500¹ int¹		0	--	--	--	--
rs7125607^1,2	C,F,A,H,	--	17096150(+)	`AAACTA/TCTGAA`	2	--	ds500¹ int¹		23		EA NA NS WA CSA	1509

HapMap Linkage Disequilibrium report for RPS13 (17095936 - 17099334 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RPS13: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPS13

DNA2.0 Custom Variant and Variant Library Synthesis for RPS13

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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RPS13 for disorders           About GeneDecksing

OMIM gene information: 180476    OMIM disorders: --

2 diseases for RPS13:    About MalaCards

gastric cancer malaria

1 Novoseek disease relationship for RPS13 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	2	16761435 (2)

Export disorders for RPS13 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RPS13 gene, integrated from 9 sources (see all 70):
(articles sorted by number of sources associating them with RPS13)

Utopia: connect your pdf to the dynamic
world of online information

Cloning and analysis of the human S13 ribosomal protein cDNA. (PubMed id 8332508)^{1, 2, 3} Chadeneau C.... Denis M.G. (1993)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{1, 2} Rush J.... Comb M.J. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A map of 75 human ribosomal protein genes. (PubMed id 9582194)^{1, 3} Kenmochi N.... Page D.C. (1998)
Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699)^{1, 2} Vladimirov S.N.... Otto A. (1996)
U14 snoRNAs are encoded in introns of human ribosomal protein S13 gene. (PubMed id 8920921)^{1, 2} Kenmochi N.... Tanaka T. (1996)
Human ribosomal protein S13 regulates expression of its own gene at the splicing step by a feedback mechanism. (PubMed id 17881366)^{1, 9} Malygin A.A....Karpova G.G. (2007)
Human ribosomal protein S13: cloning, expression, refolding, and structural stability. (PubMed id 15680243)^{1, 9} Malygin A....Karpova G. (2005)
Ribosomal proteins S13 and L23 promote multidrug resistance in gastric cancer cells by suppressing drug-induced apoptosis. (PubMed id 15149863)^{1, 9} Shi Y....Fan D. (2004)
The human EKC/KEOPS complex is recruited to Cullin2 ub iquitin ligases by the human tumour antigen PRAME. (PubMed id 22912744)¹ Costessi A....Stunnenberg H.G. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6207	HGNC: 10386	AceView: RPS13	Ensembl:ENSG00000110700	euGenes: HUgn6207
ECgene: RPS13	Kegg: 6207	H-InvDB: RPS13

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RPS13	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RPS13 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for RPS13 gene:
Search GeneIP for patents involving RPS13

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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ribosomal protein S13

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