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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPS13 Gene

protein-coding   GIFtS: 62
GCID: GC11M017055

Ribosomal Protein S13

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ribosomal Protein S131 2
40S Ribosomal Protein S131 2
S132

External Ids:    HGNC: 103861   Entrez Gene: 62072   Ensembl: ENSG000001107007   OMIM: 1804765   UniProtKB: P622773   

Export aliases for RPS13 gene to outside databases

Previous GC identifers: GC11M018166 GC11M018039 GC11M017135 GC11M017060 GC11M017054 GC11M016780


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RPS13 Gene:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This
gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S15P family
of ribosomal proteins. It is located in the cytoplasm. The protein has been shown to bind to the 5.8S rRNA in
rat. The gene product of the E. coli ortholog (ribosomal protein S15) functions at early steps in ribosome
assembly. This gene is co-transcribed with two U14 small nucleolar RNA genes, which are located in its third and
fifth introns. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of
this gene dispersed through the genome. (provided by RefSeq, Jul 2008)

GeneCards Summary for RPS13 Gene: 
RPS13 (ribosomal protein S13) is a protein-coding gene. Diseases associated with RPS13 include influenza, and gastric cancer, and among its related super-pathways are Eukaryotic Translation Initiation and Formation of the ternary complex, and subsequently, the 43S complex. GO annotations related to this gene include structural constituent of ribosome and mRNA binding.

Gene Wiki entry for RPS13 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPS13 gene promoter:
         Nkx3-1   AP-2rep   p53   AP-1   Nkx3-1 v1   YY1   GATA-1   Nkx3-1 v2   Ik-2   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRPS13 promoter sequence
   Search SABiosciences Chromatin IP Primers for RPS13

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15   Ensembl cytogenetic band:  11p15.1   HGNC cytogenetic band: 11p

RPS13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS13 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M017055:  view genomic region     (about GC identifiers)

Start:
17,095,936 bp from pter      End:
17,099,334 bp from pter
Size:
3,399 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RS13_HUMAN, P62277 (See protein sequence)
Recommended Name: 40S ribosomal protein S13  
Size: 151 amino acids; 17222 Da
1 PDB 3D structure from and Proteopedia for RPS13:
3J3A (3D)    
Secondary accessions: B2R549 P19116 Q02546 Q29200 Q498Y0

Explore the universe of human proteins at neXtProt for RPS13: NX_P62277

Explore proteomics data for RPS13 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P62277

  • RPS13 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RPS13 Protein Expression
    REFSEQ proteins: NP_001008.1  
    ENSEMBL proteins: 
     ENSP00000228140   ENSP00000435777   ENSP00000432096  
    Reactome Protein details: P62277
    Human Recombinant Protein Products for RPS13: 
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    Novus Biologicals RPS13 Proteins
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RPS13 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA17881366
    GO:0005730nucleolus IDA17881366
    GO:0005829cytosol TAS--
    GO:0005840ribosome NAS8332508

    RPS13 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RPS: S ribosomal proteins

    4 InterPro protein domains:
     IPR023029 Ribosomal_S15P
     IPR012606 Ribosomal_S13/S15_N
     IPR000589 Ribosomal_S15
     IPR009068 S15_NS1_RNA-bd

    Graphical View of Domain Structure for InterPro Entry P62277

    ProtoNet protein and cluster: P62277

    1 Blocks protein domain: IPB012606 Ribosomal S13S15 N-terminal

    UniProtKB/Swiss-Prot: RS13_HUMAN, P62277
    Similarity: Belongs to the ribosomal protein S15P family


    RPS13 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for RPS13:
    60S ribosomal protein S13

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003729mRNA binding IDA17881366
    GO:0003735structural constituent of ribosome IEA--
    GO:0005515protein binding IPI12054647
         
    RPS13 for ontologies           About GeneDecksing


    Phenotypes:
         7 GenomeRNAi human phenotypes for RPS13:
     Decreased Hepatitis C virus re  Decreased cell number  Decreased viability  Decreased viability of wild-ty 
     Increased cell number in G2M,   Nuclear 40S maturation defects  Nucleolar pre-40S maturation d 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RPS13 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RPS13 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RPS13 About   (see all 7)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Viral mRNA Translation
    Influenza Life Cycle0.95
    3' -UTR-mediated translational regulation0.93
    Influenza Infection0.95
    L13a-mediated translational silencing of Ceruloplasmin expression0.93
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Formation of a pool of free 40S subunits0.90
    Eukaryotic Translation Termination0.94
    Nonsense-Mediated Decay0.84
    2Translation initiation complex formation
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.95
    Formation of the ternary complex, and subsequently, the 43S complex0.87
    Ribosomal scanning and start codon recognition0.95
    Translation initiation complex formation0.87
    3Metabolism of mRNA
    Metabolism of mRNA0.92
    Metabolism of RNA0.92
    4Generic Transcription Pathway
    Gene Expression0.47
    5Asparagine N-linked glycosylation
    Metabolism of proteins0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPS13
        CFTR translational fidelity (class I mutations)

    2 BioSystems Pathways for RPS13
        Cytoplasmic Ribosomal Proteins
    TNF-alpha/NF-kB Signaling Pathway

    5/27        Reactome Pathways for RPS13 (see all 27)
        Formation of the ternary complex, and subsequently, the 43S complex
    Nonsense Mediated Decay Independent of the Exon Junction Complex
    Nonsense-Mediated Decay
    Translation
    SRP-dependent cotranslational protein targeting to membrane


    1         Kegg Pathway  (Kegg details for RPS13):
        Ribosome


    RPS13 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RPS13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/984 Interacting proteins for RPS13 (P622771, 2, 3 ENSP000002281404) via UniProtKB, MINT, STRING, and/or I2D (see all 984)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPL8P629172, 3, ENSP000002625844MINT-6542674 MINT-6489539 MINT-6488791 I2D: score=2 STRING: ENSP00000262584
    RPL11P629132, 3, ENSP000003636764MINT-6542674 MINT-6489539 MINT-6488791 I2D: score=1 STRING: ENSP00000363676
    RPL12P300502, 3, ENSP000003547394MINT-6542674 MINT-6489539 MINT-6488791 I2D: score=1 STRING: ENSP00000354739
    RPL13P263732, 3, ENSP000003078894MINT-6542674 MINT-7947479 MINT-6488791 I2D: score=1 STRING: ENSP00000307889
    RPL26P612542, 3, ENSP000002938424MINT-6542674 MINT-6489539 MINT-6488791 I2D: score=1 STRING: ENSP00000293842
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--
    GO:0006415translational termination TAS--

    RPS13 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RPS13 (RS13)

    Search CenterWatch for drugs/clinical trials and news about RPS13 / RS13

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RPS13 gene: 
    NM_001017.2  

    Unigene Cluster for RPS13:

    Ribosomal protein S13
    Hs.446588  [show with all ESTs]
    Unigene Representative Sequence: BE621497
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000531008 ENST00000531908 ENST00000228140 ENST00000526895 ENST00000525634(uc001mmp.3)
    ENST00000525828 ENST00000533969 ENST00000527571 ENST00000534329 ENST00000528074

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Additional mRNA sequence: 

    AK312060.1 BC000475.1 BC006772.1 BC029732.1 BC066322.1 BC100032.1 L01124.1 L05090.1 
    X79239.1 

    24/45 DOTS entries (see all 45):

    DT.100034195  DT.91780893  DT.91780905  DT.100060141  DT.95377158  DT.97814138  DT.100689183  DT.120736380 
    DT.100689171  DT.120736387  DT.100689181  DT.120736393  DT.100060137  DT.121431383  DT.100689168  DT.100689186 
    DT.120736385  DT.120736420  DT.121431378  DT.421641  DT.85101328  DT.91780895  DT.100689175  DT.120736415 

    1408 AceView cDNA sequences (see top 24):

    BQ637792 AA664797 BE257429 AI735018 BQ066459 BF219980 AW517778 AJ714660 
    BU579524 AI459647 AV653075 AA725541 BI760789 BQ879436 BU789291 BU625492 
    BM741601 BQ432432 BM799019 BE258513 AI720395 AA331024 BU146792 BQ029243 
    BP429196 BC029732 CA431313 AA187255 AI720886 AA953225 AW009093 BQ030013 
    BQ639755 AA302134 BI493905 BE251501 BU679483 AA962005 F24432 BM553813 
    BM787398 AA354565 BE252381 AI718684 AI734986 AI926540 AV726522 T62503 
    AA402314 AI089842 AI937340 AJ712857 BE394009 BG111520 AI097156 AA364123 
    CB121014 AI905747 F27221 BG112805 BE874617 BC000475 BM710756 AW778842 
    AA362560 BQ225417 D54877 AJ712535 BM457861 CD679379 BF984127 AA384196 
    AA323186 BG390965 BG029453 AI889753 BU175796 AI708434 AA327493 BM090888 
    BI859453 BP432733 NM_001017 AJ714645 AA381430 AA058366 BI818219 BM663268 
    H88810 BG032855 F37479 AA299242 BQ228182 AA904908 BM787034 BU153845 
    AA182795 AW169253 BG109832 BG661045 BU581572 W94223 BF797513 BI756632 
    T71230 AI817402 AA307907 AA968698 BI791756 BQ946032 CD107203 BC006772 
    BE621065 BE785055 AA088234 AA384461 AA357076 H92877 AA496276 BQ877588 
    AA181849 AA310095 BQ428292 AI359715 BM310022 AA356784 AI707971 F20705 
    AW262873 AV682140 BG753030 AI124939 AA354374 BM823786 BM739047 N74275 
    AI678928 AI246512 AI510712 BM090669 AI128322 AA343539 BE908412 AI630269 
    BQ581413 BU859809 AA297417 BM894359 BM887870 AI734831 AI333614 F21570 
    AA330191 BE296183 CA430093 CB240921 BU629092 F27219 AA371160 BG034619 
    BE910672 BU162198 AA376420 BF238244 R99496 BQ423140 AA157058 AA384825 
    AI801208 BG029067 AI276818 AI469128 AI268735 BM543255 BQ640739 N35627 
    R46691 AI734987 BG114389 BU730897 AA327277 BM548756 AA757893 BG254654 
    AA355317 CD677649 AI364535 BE906687 BM835666 AA187240 CB138374 CA425268 
    BF033425 BM904664 AA340421 W32563 AA487762 AI125612 BM310297 AA523993 
    BU164415 AI339768 AI937127 AA844526 BF940120 BM468656 AA113024 BM782889 
    BF939843 CD677492 AA402730 AA731728 D57467 BG107701 AA308841 AI186788 
    AV712377 AA307474 AA301656 AA341558 BI520339 BM841859 AI290939 AA576577 
    AW337426 AI083700 AA626437 BE905984 BQ636980 F25849 BI858486 AA494545 
    BM553340 BQ127980 BM841621 BQ277838 T69927 AA381436 BM006169 CN485114 
    F21917 NR_001452 AI124967 BM758837 CD677360 BG686936 CA843734 AA317959 
    AW474405 CB113644 AV712079 BQ353162 AA353627 BF032207 BM817860 BG474759 
    BG289197 H80045 F24757 BM696883 BM472725 BM850673 BM760675 AW272209 
    BM708999 AA151632 BX361630 AA343775 AI494588 BQ215924 N26415 AJ715107 
    AW672847 AI709031 BF663615 BG941783 AA486294 BI823795 AA358201 AI708482 
    AI633078 AI580784 BU595957 BG755261 AI719378 BE275213 CB141937 R46692 
    AA301993 BE879581 CA455450 CB149068 CB139876 BE881736 AA353837 AI690380 
    N33498 BG029746 BG613389 L01124 BC066322 N33098 AI735537 F31405 
    AA301701 F31314 AA303114 H92878 BE268847 BU602524 BP430615 F19571 
    BG498361 BM014047 AA653798 CB125025 BQ673675 AI057620 AA226149 AI339562 
    CB243354 BE537186 CD522572 BG477657 BE874193 BF688748 BF690830 BG107775 
    BU540215 BE292745 CB137841 AA961710 AA968549 BM792523 AA375053 AA298984 
    BE612657 AW769834 BP340802 AA340968 BG820730 H46227 AA187387 F01242 
    AJ705356 AI246326 AI392641 H41224 X79239 CB133612 BG031097 BE904784 
    BP342594 W79366 AA306108 BU941324 BU602246 BG030773 AA782348 BG940766 
    AA353419 CD050699 AI253713 AW327425 CA420557 BU603792 CD239658 CD520675 
    AJ712661 CD238208 AA758910 BM819835 CB106971 CA338114 W76629 BM841698 
    BM006039 BM844458 BG029513 AI344700 BI764632 AA976123 AI185120 N40030 
    BU571091 BP341142 BG167771 AW675523 BQ018431 AA328968 AA873859 AA309631 
    AA295181 CA843486 AA304624 AA857183 AI457860 BI791843 BU597510 W72928 
    BU935288 BU537853 BU601133 BG170030 AA491537 AA843824 AI750089 AI880858 
    D57785 BF032527 BU656665 AI124913 BM810781 T49638 BQ001223 AI424167 
    AA328429 AW059644 F24761 AA374746 BE350629 AI879922 CB054388 BU533345 
    BU859107 AI290903 CD522022 AA353656 BG754089 BG386887 AA355133 BM830283 
    BE881970 BG114305 CD679048 CD641512 AA308313 BE122667 BF184566 BM010053 
    CB134927 BE788744 BP431471 CD238918 T69984 BG941943 N48706 AA307725 
    F21725 BE790432 F18012 F16037 BU500648 AI051139 AA157041 BM263506 
    BU590374 AA316908 AA342567 AA305786 BQ277564 CB127522 AI223993 AW778872 
    BU198858 AI707927 AA082503 H46226 AW275261 BQ028448 AJ574015 AJ572423 
    BG473330 BG942578 AA226338 BP429206 BE277559 CB133449 BU600970 AW264120 
    D11722 AA335035 AA330225 BM781737 AA383079 CB105347 AI080568 BG563001 
    F29191 BG766543 W46895 CA947010 L05090 F21941 AA130484 BF663943 
    F18961 BF477939 N53612 AJ713554 AW268154 BX403841 BG944302 BP342148 
    CB107361 AI186908 H89034 BM841057 AA378336 BU198782 AA879023 CD238537 
    BU155858 T49639 BG329181 BG250168 F32098 AA343540 AA169603 BG779795 
    D58005 AW248305 BG287590 BG751195 AA364166 F28041 AV712073 AA358683 
    BE908550 CA443123 AA324579 AI718205 CD000187 CD109144 BU597275 BF204519 
    AW023292 BG755983 AA635718 AA384544 AA320430 N78579 BE545833 BM850486 
    BE907026 AA187904 BU599610 T48610 BG499333 AA100006 AA374537 BV199571 
    AA300797 AA937791 AA372661 AA341492 CD238919 BG754356 BM013815 BF032669 
    BF973913 AA338150 AI434152 AI708691 BE551431 AA303414 F25937 AA988353 
    D57666 BG502803 BM768486 F28305 CA433083 CB243292 F32341 AI608901 
    AI620685 BI091355 CB138947 F37469 AW512841 BF338179 BE548986 N27292 
    H25440 BQ003735 BI194915 BM740719 AW160947 CB139993 BF666330 BU935084 
    BM764551 BF035555 BX366070 AA342826 AI344632 BU941124 AI302885 BQ940676 
    AA352139 AV711918 AI754492 BI199136 BQ639712 BE907235 AA470954 BI091016 
    BU533651 BU595085 AA186563 BM926686 AJ573188 AA058485 BM803535 AJ714884 
    AW063942 BU960530 F33135 BM685901 BU198173 BU734104 BP366587 BF695806 
    AA182770 BQ277185 BX332051 AA303715 BP428989 AA379895 BF316466 AA629641 
    AA321033 BM972004 BQ433701 AA318552 H25485 AA328746 BM773090 BG032453 
    BU531705 BF700083 CD249447 AA194471 BU954967 AA169598 CB133328 AA317781 
    BU537891 BG112204 CB133327 AA094373 CB137299 BU594844 CB149744 CD251001 
    AA835422 BG494891 AA379838 AA308522 AA325764 BU854924 AA985553 R21936 
    N44669 D54018 BQ270488 BU533783 AA295692 CF123799 CA443149 AI146416 
    AA357085 AA854190 AI061362 AA069698 AI865203 AI199209 BG531130 CF123920 
    AA470979 CB117112 AA630915 BI859764 CD699197 D51102 AA358684 AA094993 
    BF669062 BU674120 CB991961 AA657606 BU502156 D56809 AA574395 F21440 
    AA314172 AA469894 CA453650 BU581246 CA944761 CF124282 BF666078 BE742324 
    AA131181 BU954424 BU934649 CF124029 CK906019 AI709374 BQ695287 BQ000872 
    F32838 CB991062 AJ573914 CN484801 F35508 AA304299 BI767795 AA364867 
    R22585 CD175251 AI190527 AW192797 AW264827 AW189051 AI748921 AA380056 
    BP366649 AA299064 AA094450 BG290458 BU565708 BI838309 AA374763 AA602192 
    CF124749 N70084 AJ571871 BM690444 AA908743 AA327240 BE390494 BQ269100 
    BG503243 AA377777 AW410536 N89300 N43784 BG502099 BU199324 AA309739 
    AA854172 T47033 CF123807 CF123777 BM796093 CB146265 BF699942 AV712176 
    BM763103 AA305324 W94697 AA186585 BU565252 AA228785 AI350382 AA228840 
    T48609 AA225659 R36182 AA187788 BU198522 CB144731 AI708787 AA342300 
    BQ366240 BU199006 AA328014 AA186908 AI857612 F35369 AA353970 AW410419 
    AA384496 AA379341 AA470488 BU954643 BF032056 CF124443 T72932 BI596629 
    W07174 BF942307 R21977 AA772025 AA312325 BG897565 BF981233 AA362799 
    BI604198 BQ223465 D58172 AJ713766 W04375 BQ278397 AI719754 AA379730 
    CD175028 CD385019 D19719 CD696752 BU933451 BG532770 BQ270271 BI493970 
    W31048 AA469024 AA639063 BF207744 AW238205 BM857648 BU199317 BF036435 
    BU070734 BF572592 BI194864 CD642118 BF942395 AA132095 N86139 AA468013 
    AI817300 BE744635 D54781 BQ218004 BF803632 BE737792 BG506858 CD248173 
    AA714994 AW873453 BQ305505 CA453755 CD522257 AA573981 AA091466 BQ278249 
    BG231458 AV755704 R25194 BQ268241 AJ574174 AA229833 CF123947 BQ953202 
    BU854409 BU568727 BG898827 BI907735 CD693300 AV724713 BG574522 CD247424 
    CB133738 BF797511 CD237404 CD050099 BU954072 CF123651 BF665363 CF124518 
    CD640888 BQ417007 BM740727 BU160484 CF124913 BU935468 BU537069 AA352258 
    AA157604 BU588381 R21978 BF942019 BG285519 CD248604 BU953433 CD176691 
    AV715824 BM793859 BG778628 CD708836 AI188800 BF028271 AI004866 BU598301 
    BI917694 CD176636 CB147952 AV760581 CD640329 BG564209 CD173195 CB996295 
    AA302071 BQ432143 BG714183 BQ276783 BU598993 AA157612 CD709815 CD176166 
    BQ228449 AA630914 CF124692 AI302342 CA336125 BP432744 AV760175 BG026099 
    BM552472 BU601671 BP367693 AA640768 CD107492 BF244367 H89536 AV762744 
    W76029 BG180258 CD640181 AA248123 BU600180 AV762583 AA354223 AI866688 
    AA226613 BQ323998 AI000058 BG771403 BU600882 CF124034 AI184759 CD520660 
    AA533263 BU685268 BI253293 AV759392 BG929032 BG029841 AV701531 AJ705379 
    AA331313 BI909438 BU597109 CD638664 BE785472 AA321172 CF124649 T27886 
    AA639041 BU597581 AI630556 BG504313 AI905279 BG924831 BG621162 CD176265 
    BG503418 BM712174 BM830220 AA305830 R99495 AJ712896 BG397910 BQ058848 
    AV762404 W39155 BU595247 CF124084 AI796576 BU955294 CF123838 AA088352 
    CD701617 AI750099 W17391 BE251927 BU953242 CB854439 BM263818 CF124532 
    AJ714293 BU532058 BU954019 BE267807 BG499410 BU169654 BF690986 CF123652 
    BX374829 CD638735 F37691 BU953326 AI748992 AA362362 BG757648 AI749408 
    BF942398 BG498646 BG336531 CD387117 AA360203 CD557250 BF185910 BU954422 
    CD638279 BG501706 CF123958 AV707705 CD249843 BG504644 AI084351 AI905778 
    AV737765 BU509656 CD049250 BU198980 BG499917 BG699690 CD386021 CD385001 
    BF130670 BG500198 CB108144 AI205758 BQ349236 AA320371 AA661774 F25458 
    BE564707 CD175777 AI269773 BI496445 AV742288 CD248254 BG027425 BI602389 
    BI760169 BF103914 AV755737 BU954899 BG776727 BF239971 AA876965 AV756462 
    AV756963 BM045632 BU940661 D56841 BF126409 CD387140 BF207542 CD174303 
    CD250215 BF210732 BG569655 CD246773 AV737632 BG616579 BG532214 BE312424 
    AA321642 BU933251 AA354880 BG704139 BG613582 BP432629 BE906667 AV763816 
    BI497228 CD048226 AV743761 CD172694 AI474347 AV758346 AV760709 BE732490 
    BE785092 BI667851 BG500898 BF215143 CF124329 CD247841 AV737936 AA371321 
    AA501462 CD248299 AJ714050 BE256252 CD384892 AV757043 BU536991 BF212505 
    BG563310 BQ222078 CD248394 BM508132 AA226548 AA360202 BU595470 W32683 
    AV704998 AA330141 CF122714 AA362363 BG776388 AA652127 BG708604 BX403118 
    BG529333 BU954221 AI309565 BG153029 AW063671 CF596536 AA328004 CD641202 
    CD384995 AA376206 AJ712287 BQ350744 AI128850 AV740624 AI708938 BQ323591 
    BF307224 CB963089 BG502694 BF184219 BG772845 AA095379 AJ713872 AA879158 
    CD389475 BG151287 BU933454 CD385220 BF307295 CD386565 BU598651 CD388998 
    BI669116 AA649525 BU535894 CD048606 AA935022 CF124200 AI905713 AA332998 
    BG532182 R24700 BG776611 CD386989 AW455195 BG530631 BG576462 BG759021 
    BG493805 CD555953 BQ213489 BQ721625 BG611092 CD357783 BG687243 AV760827 
    BU942547 BI552263 CD686667 CB998479 CD384935 BG612264 AV758205 BQ324318 
    BE386222 AV757994 F20330 AA305532 BI161231 BF573499 BG028415 CD511654 
    AA090430 AJ712603 AA086364 AA353393 BU933275 BF697949 AA528708 H80044 
    BG612403 AW265505 CD387069 AV739618 AA782552 BG495683 BG497823 AA536109 
    CD049806 BF766426 AV737289 BU602502 AV756905 BM829707 CB160774 AI220841 
    AV758350 BF244658 AI079142 BG497256 AI707838 CB133525 BU959563 BG230659 
    CF129259 BI021307 CF124352 BF238872 CD102229 AA327837 N89089 BF244712 
    CD684490 AV714968 CF123537 AW952932 CD248347 BF238516 CD049079 AI525777 
    D57647 BG256046 BG616312 BG615453 AA327886 AA911454 W49588 AV763880 
    BF184695 AV743580 AV755339 CD517749 BQ653597 R81761 BU853995 BF239189 
    CA337998 CD051216 BG502362 BG615230 BF677659 R36087 AA151829 D56593 
    BU198190 BF212340 BM841699 AA642873 BF219128 D58119 CF995276 AV736512 
    BE410123 BU596028 BG112441 BE973710 AA876942 BF218425 BG533724 BQ233512 
    AA746972 AA725481 AV758645 BG501686 BF681538 AA876673 AV713565 BI762943 
    BU198839 F25710 AJ715052 AI491972 BU195584 AI832487 BF674899 AV714870 
    AV740712 BU963570 BG032784 R57292 D53972 BF674404 BE878441 BU940574 
    BE735274 BG528202 BG756071 AA373038 BG027263 BU534216 AV738225 BG702425 
    BF991182 BQ225272 BF214032 BF212043 AA483077 BG615811 AI537440 CF124483 
    BQ377376 BF804651 BQ315803 CB959022 AA093477 BE743016 AI250420 N88568 
    BI910619 AA725391 AI188900 AA503047 D58350 BU955090 BQ877146 BE542124 
    AW806180 AV757036 BF692581 AI708023 BU532103 AV715211 AI204477 AI611551 
    AV756463 AW674177 AW440220 AV756041 BE857543 AV744454 AA737748 AJ713963 
    AA130483 BF211236 AI337510 BU588326 BF246482 BU566571 AA932715 BF382941 
    BF239996 AV713608 AW381355 BG503093 AW197393 BF700334 AI708094 BG495528 
    AA090873 AA096238 BF573474 AV737766 CD694519 AV756739 AI148921 BF242340 
    AV737226 BQ316863 BQ337955 BF803652 AA574319 BF241194 BF804751 BG875244 
    BF746938 N86792 H26031 AI905707 CB136799 AA330799 BU960308 AA471136 
    AV712015 CD513275 D53381 AA095523 AA729524 AA640266 AW440196 N83456 
    BG033756 BQ316862 AA187569 D57768 BF670822 BF205522 N29640 BF382499 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RPS13    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6
    SP1:                                                                        
    SP2:                                      -     -     -                     
    SP3:                                                                        
    SP4:                                                                        
    SP5:                                                                        


    ECgene alternative splicing isoforms for RPS13

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPS13 expression in normal human tissues (normalized intensities)      RPS13 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGTTGCACA
    RPS13 Expression
    About this image


    RPS13 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Ovary (Reproductive System)
             Primary Oocyte Primary Follicle
     
     Gonad
             Primary Oocyte Primary Follicle
     
     Umbilical Cord (Extraembryonic Tissues)

    See RPS13 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPS13

    SOURCE GeneReport for Unigene cluster: Hs.446588
        SABiosciences Custom PCR Arrays for RPS13
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RPS13
    OriGene qSTAR qPCR primer pairs in human, mouse for RPS13
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RPS13
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS13
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS13
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPS13

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPS13 gene from 10/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rps131 , 5 ribosomal protein S131, 5 86.98(n)1
    100(a)1
      7 (61.61 cM)5
    680521  NM_026533.31  NP_080809.11 
     1163315075 
    chicken
    (Gallus gallus)
    Aves RPS131 ribosomal protein S13 81.68(n)
    100(a)
      414782  NM_001001783.1  NP_001001783.1 
    lizard
    (Anolis carolinensis)
    Reptilia RPS136
    Uncharacterized protein
    100(a)
    1 ↔ 1
    1(66622601-66629484)
    African clawed frog
    (Xenopus laevis)
    Amphibia rps13-prov2 ribosomal protein S13 81.14(n)    BC056028.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570848262   -- 78.84(n)    57084826 
    fruit fly
    (Drosophila melanogaster)
    Insecta RpS131 , 3 protein biosynthesis structural
    constituent of more3
    Ribosomal protein S131
    87(a)3
    71.08(n)1
    87.42(a)1
      2 29B23
    341491  NM_001038796.21  NP_001033885.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rps-131 , 3 40S ribosomal protein S133
    Protein RPS-131
    76(a)3
    68.43(n)1
    76.16(a)1
      III(6445813-6446906)3
    1759011  NM_065992.41  NP_498393.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPS13(YDR064W)4 Protein component of the small (40S) ribosomal subunit; more   --   4(579458-580452) 851636  NP_010349.1 
    soybean
    (Glycine max)
    eudicotyledons 467773542   -- 71.11(n)  
    rice
    (Oryza sativa)
    Liliopsida Os.151682 Oryza sativa (japonica cultivar-group) cDNA clone0 more 71.08(n)    AK059505.1 


    ENSEMBL Gene Tree for RPS13 (if available)
    TreeFam Gene Tree for RPS13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPS13 gene
    18/48 SIMAP similar genes for RPS13 using alignment to 3 protein entries:     RS13_HUMAN (see all proteins) (see all similar genes):
    RRM2B    EIF3G    LSM12    C12orf76    UBXN4    ADCK1
    EIF3K    DOCK8    TNNT1    FLJ00047    ZNF799    EEF1E1
    GALK2    PFKFB3    C21orf37    DYNC2LI1    COQ5    VPS33A

    RPS13 for paralogs           About GeneDecksing


    5/11 Pseudogenes.org Pseudogenes for RPS13 (see all 11)
    PGOHUM00000246797 PGOHUM00000247118 PGOHUM00000244031 PGOHUM00000245058 PGOHUM00000239991


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/37 SNPs in RPS13 are shown (see all 37)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs110241471,2
    C,F,A,H--17095565(+) ATTACT/GTTTGC 1 -- ds500110Minor allele frequency- G:0.20NS EA WA CSA 786
    rs169248991,2
    C,F,H--17095596(+) TCTGAT/CGCTAC 1 -- ds500127Minor allele frequency- C:0.18NA NS EA CSA WA EU 3425
    rs1882470661,2
    --17095686(+) ATGACA/GCCAAA 1 -- ds50010--------
    rs1168494251,2
    C,F--17095699(+) AAACAC/AAAAGG 1 -- ds50011Minor allele frequency- A:0.02EA 120
    rs728708891,2
    C,F--17099600(+) ACTAGA/TTCCCT 1 -- us2k12Minor allele frequency- T:0.01NA NS 270
    rs169338231,2
    C,F,H--17099613(+) GAGTCG/AGCCCT 1 -- us2k121Minor allele frequency- A:0.17NA NS EA WA 2630
    rs1932727781,2
    C--17099615(+) GTCGGC/TCCTGC 1 -- us2k10--------
    rs605342231,2
    C,F--17099803(+) TGCCTG/ACCGCC 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1141697421,2
    F--17099857(+) CTCGCC/TGGGGA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs110241501,2
    C,F,A--17100265(+) CGCCTC/GGGCCT 1 -- us2k11Minor allele frequency- G:0.02NS 150

    HapMap Linkage Disequilibrium report for RPS13 (17095936 - 17099334 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RPS13:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv467711CNV Gain19166990

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RPS13
    DNA2.0 Custom Variant and Variant Library Synthesis for RPS13

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 180476    OMIM disorders: --

    3 diseases for RPS13:    About MalaCards
    influenza    gastric cancer    breast cancer


    RPS13 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for RPS13 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 2 16761435 (2)


    Export disorders for RPS13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPS13 gene, integrated from 9 sources (see all 79):
    (articles sorted by number of sources associating them with RPS13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and analysis of the human S13 ribosomal protein cDNA. (PubMed id 8332508)1, 2, 3 Chadeneau C.... Denis M.G. (1993)
    2. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. A map of 75 human ribosomal protein genes. (PubMed id 9582194)1, 3 Kenmochi N.... Page D.C. (1998)
    5. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699)1, 2 Vladimirov S.N.... Otto A. (1996)
    6. U14 snoRNAs are encoded in introns of human ribosomal protein S13 gene. (PubMed id 8920921)1, 2 Kenmochi N.... Tanaka T. (1996)
    7. Human ribosomal protein S13 regulates expression of its own gene at the splicing step by a feedback mechanism. (PubMed id 17881366)1, 9 Malygin A.A....Karpova G.G. (2007)
    8. Human ribosomal protein S13: cloning, expression, refolding, and structural stability. (PubMed id 15680243)1, 9 Malygin A....Karpova G. (2005)
    9. Ribosomal proteins S13 and L23 promote multidrug resistance in gastric cancer cells by suppressing drug-induced apoptosis. (PubMed id 15149863)1, 9 Shi Y....Fan D. (2004)
    10. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....Yanez-Mo M. (2013)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6207 HGNC: 10386 AceView: RPS13 Ensembl:ENSG00000110700 euGenes: HUgn6207
    ECgene: RPS13 Kegg: 6207 H-InvDB: RPS13

    (According to HUGE)
    About This Section
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RPS13 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RPS13 gene:
    Search GeneIP for patents involving RPS13

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