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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RPS13 Gene

protein-coding   GIFtS: 60
GCID: GC11M017055

ribosomal protein S13
 Explore 2 diseases affiliated with
RPS13 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RPS13    

Aliases
for RPS13 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ribosomal Protein S131 2
S131 2
40S Ribosomal Protein S132

External Ids:    HGNC: 103861   Entrez Gene: 62072   Ensembl: ENSG000001107007   OMIM: 1804765   UniProtKB: P622773   

Export aliases for RPS13 gene to outside databases

Previous GC identifers: GC11M018166 GC11M018039 GC11M017135 GC11M017060 GC11M017054 GC11M016780


Summaries
for RPS13 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RPS13:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene
encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S15P family of
ribosomal proteins. It is located in the cytoplasm. The protein has been shown to bind to the 5.8S rRNA in rat. The
gene product of the E. coli ortholog (ribosomal protein S15) functions at early steps in ribosome assembly. This gene
is co-transcribed with two U14 small nucleolar RNA genes, which are located in its third and fifth introns. As is
typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through
the genome. (provided by RefSeq, Jul 2008)

Gene Wiki entry for RPS13


Genomic Views
for RPS13 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPS13 gene promoter:
         Nkx3-1   AP-2rep   p53   AP-1   Nkx3-1 v1   YY1   GATA-1   Nkx3-1 v2   Ik-2   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RPS13 promoter sequence
   Search SABiosciences Chromatin IP Primers for RPS13

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPS13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15   Ensembl cytogenetic band:  11p15.1   HGNC cytogenetic band: 11p

RPS13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPS13 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M017055:  view genomic region     (about GC identifiers)

Start:
 17,095,936 bp from pter      End:
 17,099,334 bp from pter
Size:
 3,399 bases      Orientation:
 minus strand

Proteins
for RPS13 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RS13_HUMAN, P62277 (See protein sequence)
Recommended Name: 40S ribosomal protein S13  
Size: 151 amino acids; 17222 Da
Secondary accessions: B2R549 P19116 Q02546 Q29200 Q498Y0

Explore the universe of human proteins at neXtProt for RPS13: NX_P62277

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P62277

    • RPS13 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001008.1  
    ENSEMBL proteins: 
     ENSP00000228140   ENSP00000435777   ENSP00000432096  
    Reactome Protein details: P62277
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: RPS13
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    Novus Biologicals RPS13 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RPS13

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17881366
    GO:0005730nucleolus IDA17881366
    GO:0005829cytosol TAS--
    GO:0005840ribosome NAS8332508
    GO:0022627cytosolic small ribosomal subunit IDA8706699


    RPS13 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for RPS13

    Protein Domains /
    Families
    for RPS13 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RPS13 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR023029 Ribosomal_S15P
     IPR012606 Ribosomal_S13/S15_N
     IPR000589 Ribosomal_S15
     IPR009068 S15_NS1_RNA-bd

    Graphical View of Domain Structure for InterPro Entry P62277

    ProtoNet protein and cluster: P62277

    1 Blocks protein family: IPB012606 Ribosomal S13S15 N-terminal

    UniProtKB/Swiss-Prot: RS13_HUMAN, P62277
    Similarity: Belongs to the ribosomal protein S15P family


    Function
    for RPS13 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:
         Genatlas biochemistry entry for RPS13:
    60S ribosomal protein S13

    miRNA
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    Inhib. RNA
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    OriGene shRNA RFP: RPS13
    OriGene siRNA: RPS13
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RPS13

    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for RPS13

    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003729mRNA binding IDA17881366
    GO:0003735structural constituent of ribosome IEA--
    GO:0005515protein binding IPI12054647


    RPS13 for ontologies           About GeneDecksing


    7 GenomeRNAi human phenotypes for RPS13:
     Decreased Hepatitis C virus re  Decreased cell number  Decreased viability  Decreased viability of wild-ty 
     Increased cell number in G2M,   Nuclear 40S maturation defects  Nucleolar pre-40S maturation d 


    Pathways & Interactions
    for RPS13 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Synthesis of PB1-F2
    8/26 pathways (see all 26)
    		Viral Protein Synthesis1.00
    		Cytoplasmic Ribosomal Proteins0.86
    		Viral mRNA Translation1.00
    		CFTR translational fidelity (class I mutations)0.83
    		Influenza Viral RNA Transcription and Replication1.00
    		SMG6 Cleaves mRNA with Premature Termination Codon0.80
    		Synthesis of nascent polypeptide containing signal sequence1.00
    		L13a-mediated translational silencing of Ceruloplasmin expression0.79
    2Translation initiation complex formation
    		Translation initiation complex formation1.00
    		Ribosomal scanning and start codon recognition0.96
    		Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.98
    		Formation of the ternary complex, and subsequently, the 43S complex0.87
    3Metabolism of mRNA
    		Metabolism of mRNA1.00
    		Metabolism of RNA0.92
    4Disease
    		Disease1.00
    5TNF-alpha/NF-kB Signaling Pathway
    		TNF-alpha/NF-kB Signaling Pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RPS13
        CFTR translational fidelity (class I mutations)

    2 BioSystems Pathways for RPS13 
        Cytoplasmic Ribosomal Proteins
    TNF-alpha/NF-kB Signaling Pathway

    5/32        Reactome Pathways for RPS13 (see all 32)
        Formation of a pool of free 40S subunits
    Synthesis of PB1-F2
    SMG6 Cleaves mRNA with Premature Termination Codon
    Influenza Life Cycle
    Viral mRNA Translation


    1         Kegg Pathway  (Kegg details for RPS13):
        Ribosome


    RPS13 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RPS13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/953 Interacting proteins for RPS13 (P622771, 2, 3 ENSP000002281404) via UniProtKB, MINT, STRING, and/or I2D (see all 953)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPL8P629172, 3, ENSP000002625844MINT-6542674 MINT-6489539 MINT-6488791 I2D: score=2 STRING: ENSP00000262584
    RPL11P629132, 3, ENSP000003636764MINT-6542674 MINT-6489539 MINT-6488791 I2D: score=1 STRING: ENSP00000363676
    RPL12P300502, 3, ENSP000003547394MINT-6542674 MINT-6489539 MINT-6488791 I2D: score=1 STRING: ENSP00000354739
    RPL13P263732, 3, ENSP000003078894MINT-6542674 MINT-7947479 MINT-6488791 I2D: score=1 STRING: ENSP00000307889
    RPL26P612542, 3, ENSP000002938424MINT-6542674 MINT-6489539 MINT-6488791 I2D: score=1 STRING: ENSP00000293842
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--
    GO:0006415translational termination TAS--


    RPS13 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RPS13 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RPS13
    Search CenterWatch for drugs/clinical trials and news about RPS13 / RS13 

    Transcripts
    for RPS13 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RPS13 gene: 
    NM_001017.2  

    Unigene Cluster for RPS13:

    Ribosomal protein S13
    Hs.446588  [show with all ESTs]
    Unigene Representative Sequence: BE621497
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000531008 ENST00000531908 ENST00000228140 ENST00000526895 ENST00000525634(uc001mmp.3)
    ENST00000525828 ENST00000533969 ENST00000527571 ENST00000534329 ENST00000528074


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    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPS13 (see all 7)
    OriGene shRNA RFP: RPS13
    OriGene siRNA: RPS13
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPS13
    Clone
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    Primer
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    Additional cDNA sequence: 

    AK312060.1 BC000475.1 BC006772.1 BC029732.1 BC066322.1 BC100032.1 L01124.1 L05090.1 
    X79239.1 

    24/45 DOTS entries (see all 45):

    DT.100034195  DT.91780893  DT.91780905  DT.100060141  DT.95377158  DT.97814138  DT.100689183  DT.120736380 
    DT.100689171  DT.120736387  DT.100689181  DT.120736393  DT.100060137  DT.121431383  DT.100689168  DT.100689186 
    DT.120736385  DT.120736420  DT.121431378  DT.421641  DT.85101328  DT.91780895  DT.100689175  DT.120736415 

    1408 AceView cDNA sequences (see top 24):

    BM841621 BQ277838 T69927 AA381436 BM006169 CN485114 AI124967 NR_001452 
    F21917 CD677360 BG686936 CA843734 BM758837 AA317959 AW474405 CB113644 
    AV712079 AA353627 BQ353162 BF032207 BM817860 BG289197 BG474759 H80045 
    F24757 BM696883 BM472725 BM760675 BM850673 AW272209 BM708999 BX361630 
    AA151632 AA343775 AI494588 N26415 BQ215924 BU625492 BE785055 BM553340 
    BQ879436 BU789291 BI760789 AV653075 AA725541 AI290939 BU629092 CB240921 
    CA430093 BE296183 AA330191 F21570 AI333614 AI734831 BM887870 BM894359 
    AA297417 BU859809 BQ581413 AI630269 BE908412 AI128322 AA343539 BM090669 
    AI510712 AI246512 AA356784 CD107203 BC006772 BQ946032 BI791756 AA968698 
    AI817402 T71230 AA307907 BI756632 BF797513 W94223 BU581572 BG661045 
    BG109832 AW169253 AA182795 BU153845 BM787034 AA904908 AA299242 F37479 
    BQ228182 BG032855 H88810 BM663268 BI818219 AA058366 AA381430 AJ714645 
    NM_001017 BP432733 BI859453 BM090888 AA327493 AI708434 BU175796 AI889753 
    AA323186 BG390965 BG029453 AA384196 BF984127 BM457861 CD679379 AJ712535 
    D54877 BQ225417 AA362560 AW778842 BE874617 BC000475 BM710756 BG112805 
    F27221 AI905747 CB121014 BG111520 AI097156 AA364123 BE394009 AJ712857 
    AI937340 BE621065 AA384461 AA310095 AA357076 CA431313 AV712377 AI707971 
    N74275 AI678928 AA354374 BM823786 BM739047 AI124939 BG753030 AW262873 
    F20705 AV682140 AA181849 AI359715 AA496276 BQ877588 BQ428292 BM310022 
    AA088234 H92877 BF033425 AI083700 AA307474 BI520339 AA576577 AA341558 
    AA301656 BM904664 BQ127980 F25849 BM841859 BI858486 AA626437 AA494545 
    AA308841 AI186788 BE905984 W32563 AI459647 AA340421 BQ636980 D57467 
    BG107701 AA402730 AA731728 BM782889 BF939843 CD677492 BM468656 AA113024 
    AA844526 BF940120 AI937127 AI339768 BU164415 AA523993 AI125612 BM310297 
    AA487762 AW337426 BE906687 BM548756 N35627 CD677649 BG029067 CA425268 
    AA384825 AI801208 BQ639755 AI276818 AI469128 AI268735 BQ030013 AA157058 
    AW009093 BQ423140 R99496 BF238244 AA376420 BU162198 BM835666 R46691 
    BG114389 CB138374 AA327277 BU730897 BQ640739 BG254654 AA187240 AI734987 
    AA355317 AI364535 AA757893 BM543255 BE910672 BG034619 AA371160 F27219 
    AW517778 AI926540 AV726522 AI089842 T62503 AA402314 AI734986 AA331024 
    BE258513 AA664797 BF219980 BP429196 BQ029243 BQ637792 BQ432432 AI720395 
    BQ066459 BM799019 BM741601 BE257429 BC029732 BU146792 AA187255 AI720886 
    AA953225 AI735018 BE252381 BM553813 AA354565 BM787398 BU579524 BU679483 
    AA302134 BE251501 F24432 AA962005 BI493905 AI718684 AJ714660 BE907026 
    BU599610 T48610 AA374537 AA100006 BG499333 BV199571 AA300797 AA937791 
    AA372661 AA341492 CD238919 BG754356 BM013815 BF032669 AA338150 AI434152 
    BF973913 BE551431 AI708691 AA303414 F25937 AA988353 D57666 BG502803 
    BM768486 F28305 CA433083 CB243292 AI608901 AI620685 CB138947 F32341 
    BI091355 F37469 AW512841 BF338179 BE548986 N27292 BQ003735 H25440 
    BI194915 AW160947 BM740719 CB139993 BF666330 BM764551 BU935084 BF035555 
    AA342826 BX366070 AI344632 BU941124 AI302885 BQ940676 AA352139 AI754492 
    AV711918 BQ639712 BI199136 BE907235 BI091016 AA470954 N33098 AI735537 
    BC066322 BM810781 CA443123 BG755983 AA324579 BU595957 AI633078 AI580784 
    AI708482 AA353837 W72928 BM841057 AA364166 AJ713554 AI707927 BU198858 
    AW778872 CB127522 AI223993 AA305786 AA342567 AA316908 BQ277564 BM263506 
    F18012 BU590374 AI051139 BU500648 AA157041 F16037 BE790432 BG941943 
    N48706 F21725 AA307725 CD238918 BP431471 T69984 BE788744 CB134927 
    BM010053 BE122667 BF184566 CD641512 AA308313 BM830283 AA355133 CD679048 
    BE881970 BG114305 BG386887 AI424167 BU597510 AI457860 AA857183 BI791843 
    CA843486 AA304624 AA295181 AA873859 AA309631 AA328968 BQ018431 AW675523 
    BG167771 BP341142 BU571091 N40030 BI764632 AA976123 AI185120 BG029513 
    AI344700 BM844458 BM006039 BM841698 W76629 CA338114 AA758910 BM819835 
    CB106971 CD238208 CD239658 CD520675 AJ712661 BU603792 CA420557 AW327425 
    AI253713 AA353419 CD050699 BG940766 AA782348 BG030773 BU602246 W79366 
    AA306108 BU941324 BP342594 BE904784 BG031097 X79239 H41224 CB133612 
    AI392641 AI246326 AJ705356 F01242 AA187387 BP340802 BG820730 H46227 
    AA340968 AW769834 BE612657 BM792523 AA375053 AA298984 AA968549 CB137841 
    AA961710 BE292745 BG107775 BU540215 BF690830 BU935288 BU601133 BF204519 
    AI690380 BQ001223 BG754089 AW059644 AI879922 AI290903 CD522022 AA353656 
    CB054388 BU859107 BU533345 BE350629 AA374746 F24761 AI750089 D57785 
    AA843824 AI124913 BF032527 BU656665 T49638 AA328429 AI880858 BG170030 
    AA491537 BU537853 AA082503 BG751195 BX403841 AI718205 CB107361 BG944302 
    BG287590 CD109144 F28041 AW248305 BE545833 BU597275 BP342148 AW268154 
    BM850486 CD000187 BE908550 AV712073 AW023292 AA320430 AA358683 AA169603 
    AA384544 AA301993 AI186908 H89034 AA635718 F32098 BG779795 AA343540 
    BG250168 N78579 BG329181 T49639 BU155858 CD238537 AA879023 BU198782 
    AA378336 BF477939 BU600970 F18961 N53612 CB133449 BE277559 F19571 
    BP430615 BE268847 BU602524 AI080568 AA383079 AA330225 BM781737 AA335035 
    CB105347 D11722 BG563001 AW264120 H92878 AA303114 BP429206 BG942578 
    AA226338 BG473330 CA947010 F29191 BG766543 W46895 AA130484 BF663943 
    L05090 F21941 BQ028448 AJ572423 AW275261 AJ574015 H46226 BF663615 
    BG477657 BE874193 CD522572 BE537186 BF688748 AW672847 D58005 CB149068 
    BG755261 BE879581 N33498 CB139876 BG029746 AI709031 AJ715107 BG941783 
    AI719378 CA455450 L01124 AA358201 R46692 AA486294 BE881736 CB141937 
    BI823795 BG613389 F31405 AA301701 BE275213 AI057620 BQ673675 AI339562 
    AA226149 AA653798 BG498361 BM014047 CB125025 F31314 CB243354 AA187904 
    AA342300 BU199006 BQ366240 AA328014 AA186908 AI857612 F35369 AA353970 
    AA384496 AW410419 AA379341 BU954643 AA470488 BF032056 CF124443 BI596629 
    T72932 W07174 BF942307 R21977 AA772025 AA312325 BG897565 BF981233 
    AA362799 BI604198 BQ223465 D58172 AJ713766 BQ278397 W04375 AI719754 
    AA379730 AI350382 BU198173 BU960530 BU734104 BP366587 AJ573188 F33135 
    AW063942 BM685901 BM803535 AJ714884 AA058485 AA469894 AA379895 T48609 
    AA602192 AA374763 BI838309 AA094450 BU565708 BG290458 AA299064 BP366649 
    AI748921 AA380056 AW189051 AW264827 AW192797 AI190527 CD175251 R22585 
    BI767795 AA364867 AA304299 AA314172 F21440 D56809 AA574395 BU502156 
    AA657606 CB991961 BU674120 BF669062 AA358684 AA094993 D51102 BI859764 
    AA630915 CD699197 CB117112 AA470979 CF123920 AI865203 BG531130 AI199209 
    AA069698 AA854190 AA357085 AI061362 AI146416 CF123799 CA443149 AA295692 
    BU533783 BQ270488 D54018 N44669 R21936 AA985553 BU854924 AA325764 
    AA308522 AA379838 BG494891 AA835422 CD251001 CB149744 BU594844 CB137299 
    AA094373 CB133327 BG112204 AA317781 BU537891 CA453650 AA131181 BU581246 
    AA228840 AA321033 AI709374 F35508 AJ573914 CB991062 F32838 BQ000872 
    CN484801 BQ695287 BF666078 BE742324 CA944761 BU954424 CK906019 CF124029 
    BU934649 CF124282 BU198522 BU565252 AA228785 R36182 CB144731 AA225659 
    AI708787 AA187788 AA186585 W94697 BM763103 AA305324 AV712176 CB146265 
    BF699942 CF123777 BM796093 CF123807 BG502099 BE390494 AA327240 BM690444 
    AA908743 BG032453 N89300 AA377777 AW410536 BG503243 BQ269100 AA328746 
    BM773090 AJ571871 N70084 N43784 AA309739 T47033 AA854172 BU199324 
    CF124749 BQ433701 CB133328 AA169598 BX332051 AA182770 AA629641 BU533651 
    BF695806 AA186563 AA318552 BU595085 BQ277185 BP428989 H25485 BM972004 
    BM926686 BF316466 AA194471 CD249447 BF700083 BU531705 AA303715 BU954967 
    AV762404 W39155 BU595247 CF124084 AI796576 CF123838 BU955294 AA088352 
    CD701617 AI750099 BE251927 W17391 BU953242 CB854439 BM263818 CF124532 
    AJ714293 BU532058 BU954019 BE267807 BG499410 BU169654 BF690986 CF123652 
    BU933451 BG532770 BU600882 BU199317 CD696752 BG503418 BP432744 AV760175 
    CA336125 AI302342 AA630914 CF124692 BQ228449 CD176166 CD709815 AA157612 
    BU598993 AV715824 BM793859 CD176691 BU953433 BG285519 CD248604 BF942019 
    R21978 BU588381 AA157604 AA352258 BU935468 BU537069 CF124913 BU160484 
    BM740727 BQ417007 CD640888 CF124518 CF123651 BF665363 CD050099 BU954072 
    CD237404 BF797511 CB133738 BG574522 CD247424 AV724713 CD693300 BU568727 
    BG898827 BI907735 BU854409 BQ953202 AA229833 CF123947 AJ574174 BQ268241 
    BG231458 R25194 AV755704 BQ278249 AA091466 AA573981 CA453755 CD522257 
    BQ305505 AW873453 CD708836 AI004866 CB147952 BG026099 BQ276783 BF036435 
    BG714183 BQ432143 AA302071 CB996295 BG564209 CD173195 AI188800 AV760581 
    CD176636 BU598301 BI917694 CD640329 BF028271 BG778628 BQ270271 BG771403 
    BM712174 BG397910 AJ712896 CF124034 AA305830 R99495 AI905279 CD176265 
    BM830220 CD520660 BU597581 BG621162 AI184759 BG924831 BG504313 AI630556 
    CF124649 T27886 AA639041 AA321172 BI909438 BE785472 CD638664 BU597109 
    BG029841 AJ705379 AV759392 AV701531 AA331313 BG929032 AA533263 BI253293 
    BU685268 BQ058848 AA226613 AV762744 BF244367 AI817300 H89536 AA468013 
    N86139 AA132095 CD640181 AA248123 BG180258 W76029 CD107492 AA640768 
    BP367693 BQ323998 BU600180 AI000058 AA354223 AI866688 AV762583 BU601671 
    BM552472 AA469024 BG506858 CD248173 BE737792 AA714994 BF803632 BU070734 
    BI493970 BF207744 BM857648 AW238205 CD175028 CD385019 D19719 BF572592 
    CD642118 BI194864 W31048 AA639063 BE744635 BF942395 BQ218004 D54781 
    AA332998 BG532182 R24700 BG776611 CD386989 AW455195 BG530631 BG576462 
    BG759021 BG493805 CD555953 BQ213489 CD357783 BG611092 BQ721625 BG687243 
    AV760827 BU942547 CD686667 BI552263 CB998479 CD384935 BG612264 AA360203 
    BU198980 AI084351 CD048606 CD387117 BG336531 BG498646 BG757648 CD049250 
    BI667851 AA330141 AV704998 W32683 BU595470 AA360202 AA226548 CD248394 
    BM508132 BQ222078 BG563310 BF212505 BU509656 AV760709 AV758346 AI474347 
    CD172694 AV743761 CD048226 BI497228 AV763816 BP432629 BE906667 BG613582 
    AA354880 BG704139 BU933251 AA321642 BE312424 BG532214 BG616579 AV737632 
    CD246773 BG569655 BF210732 CD250215 CD174303 BF207542 CD387140 D56841 
    BF126409 BU940661 BM045632 AV756963 BF239971 AV756462 AA876965 BG776727 
    BU954899 AV755737 BF103914 BI760169 BI602389 BG027425 BI496445 CD248254 
    AV742288 BE785092 BF942398 AV737765 BG504644 AI749408 AV737936 CF124329 
    BU536991 CD247841 AV757043 CD384892 BE256252 AJ714050 CD248299 AA501462 
    AA371321 BG500898 BF215143 BE732490 BI669116 BU535894 BF307295 CD386565 
    CD384995 CD388998 AA649525 BU598651 AI905713 CF124200 AA935022 BQ350744 
    CD385220 BX374829 AV740624 AI128850 AJ712287 BU933454 BF184219 CB963089 
    BG151287 CD389475 AA879158 AJ713872 BG772845 AA095379 BG502694 BF307224 
    BQ323591 AI708938 AA376206 AA328004 BG699690 BX403118 BG708604 AA652127 
    BG153029 CF596536 AW063671 CD641202 AI309565 BU954221 BG529333 AA362363 
    BG776388 CF122714 CD557250 AA362362 AA661774 F25458 AA320371 CD175777 
    AI269773 BE564707 AI205758 BQ349236 CD638735 CF123958 AV707705 BG501706 
    F37691 BU953326 BF185910 AI905778 CD638279 CD249843 BU954422 AI748992 
    BG499917 CD386021 CD385001 BF130670 BG500198 CB108144 BF218425 BG533724 
    BQ233512 AA746972 AA725481 AV758645 BG501686 BF681538 AA876673 AV713565 
    BI161231 BE386222 BQ324318 BU853995 AA876942 BG256046 D57647 AI525777 
    CD049079 BF238516 AW952932 CD248347 CF123537 AV714968 CD684490 AA327837 
    N89089 CD102229 BF244712 BG497256 AI079142 BF244658 AV758350 AI220841 
    CB160774 BM829707 AV756905 BU602502 AV737289 BF766426 AA536109 CD049806 
    BG497823 BG495683 AA782552 AV739618 BG612403 CD387069 AW265505 H80044 
    AA528708 BF697949 BU933275 CB133525 CF129259 BG230659 CF124352 BF238872 
    BI021307 AI707838 BU959563 BG616312 AV736512 BG112441 BE973710 CA337998 
    BF239189 BE410123 CF995276 D58119 AA642873 BG502362 CD051216 BU596028 
    BF219128 BM841699 BF212340 BU198190 D56593 AA151829 R36087 BF677659 
    BG615230 AV755339 W49588 AA911454 AA327886 AV763880 AJ712603 AA090430 
    BG615453 R81761 BQ653597 AV743580 CD517749 BF184695 AA353393 AA305532 
    F20330 AV758205 BG028415 BF573499 CD511654 AV757994 AA086364 AA130483 
    BF211236 AI337510 BU588326 BF246482 BU566571 AA932715 BF382941 BF239996 
    AV713608 AW381355 BG503093 AW197393 BF700334 AI708094 AV756041 BF692581 
    AV757036 AW806180 BE542124 BQ877146 BU955090 D58350 AI188900 AA503047 
    AI537440 BG615811 AA483077 BF212043 BQ225272 BF214032 BF991182 AV738225 
    BG702425 BU534216 BG027263 AA373038 BG756071 BG528202 BE735274 BU940574 
    BE878441 CF124483 BU195584 AA725391 BI910619 BF804651 BQ377376 BQ315803 
    AA093477 CB959022 AI250420 BE743016 N88568 AV714870 AJ713963 AA737748 
    AV744454 BE857543 AI611551 AI204477 AV715211 BG032784 BU532103 AI708023 
    AW674177 AV756463 AW440220 BF674404 AV740712 BI762943 BF674899 BU198839 
    AI491972 AI832487 AJ715052 BU963570 F25710 D53972 R57292 BF746938 
    N86792 H26031 AI905707 CB136799 AA330799 AA574319 BF803652 BQ337955 
    BQ316863 AV737226 AI148921 AV756739 CD694519 AV737766 BF573474 AA096238 
    AA090873 BF242340 BG875244 BF804751 BF241194 BG495528 AV712015 AA187569 
    N83456 AW440196 AA640266 AA729524 AA095523 D53381 BQ316862 BG033756 
    BF670822 BF382499 N29640 BF205522 D57768 CD513275 BU960308 AA471136 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RPS13    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6
    SP1:                                                                        
    SP2:                                      -     -     -                     
    SP3:                                                                        
    SP4:                                                                        
    SP5:                                                                        


    ECgene alternative splicing isoforms for RPS13

    Expression
    for RPS13 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RPS13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGTTGCACA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RPS13 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryPrimary FolliclePrimary OocyteFemale Gametocytes, Germ Cells
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RPS13 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RPS13

    SOURCE GeneReport for Unigene cluster: Hs.446588
        SABiosciences Custom PCR Arrays for RPS13
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPS13
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RPS13
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPS13
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPS13
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RPS13

    Orthologs
    for RPS13 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RPS13 gene from 9/38 species (see all 38)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rps131 , 5 ribosomal protein S131, 5 86.98(n)1
    100(a)1    		   7 (61.61 cM)5
    680521  NM_026533.31  NP_080809.11 
     1163315075 
    chicken
    (Gallus gallus)    		 Aves RPS131 ribosomal protein S13 81.68(n)
    100(a)    		   414782  NM_001001783.1  NP_001001783.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RPS136
    		 --
    		 100(a)
    		 1 ↔ 1
    		 1(66624651-66629484)
    African clawed frog
    (Xenopus laevis)    		 Amphibia rps13-prov2 ribosomal protein S13 81.14(n)    BC056028.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii 570848262   -- 78.84(n)    57084826 
    fruit fly
    (Drosophila melanogaster)    		 Insecta RpS131 , 3 protein biosynthesis structural constituent
    of more3
    Ribosomal protein S131    		 87(a)3
    71.08(n)1
    87.42(a)1    		   2 29B23
    341491  NM_001038796.21  NP_001033885.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea rps-131 , 3 40S ribosomal protein S133
    Protein RPS-131    		 76(a)3
    68.43(n)1
    76.16(a)1    		   III(6445813-6446906)3
    1759011  NM_065992.41  NP_498393.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ATRPS13A6
    AT3G607706
    		 40S ribosomal protein S13-1
    		 79(a)
    78(a)
    		 many → 1
    many → 1
    		 4(37084-38312)
    3(22460189-22461779)
    rice
    (Oryza sativa)    		 Liliopsida Os.151682 Oryza sativa (japonica cultivar-group) cDNA clone0 more 71.08(n)    AK059505.1 


    ENSEMBL Gene Tree for RPS13 (if available)
    TreeFam Gene Tree for RPS13 (if available) 

    Paralogs
    for RPS13 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RPS13 gene
    18/41 SIMAP similar genes for RPS13 using alignment to 3 protein entries:     RS13_HUMAN (see all proteins) (see all similar genes):
    RRM2B    EIF3G    LSM12    C12orf76    UBXN4    ADCK1
    EIF3K    DOCK8    FLJ00047    EEF1E1    GALK2    PFKFB3
    C21orf37    DYNC2LI1    COQ5    NCKAP1L    SH2B3    RHBG

    RPS13 for paralogs           About GeneDecksing


    5/11 Pseudogenes.org Pseudogenes for RPS13 (see all 11)
    PGOHUM00000246797 PGOHUM00000247118 PGOHUM00000244031 PGOHUM00000245058 PGOHUM00000239991


    Genomic Variants
    for RPS13 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/109 NCBI SNPs in RPS13 are shown (see all 109)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1169620131,2
    		--17095486(+) CCTCCA/GGTGAC 1 -- ds50011Minor allele frequency- G:0.01NA 120
    rs110241471,2
    		C,F,A,H,--17095565(+) ATTACT/GTTTGC 1 -- ds500110Minor allele frequency- G:0.20NS EA WA CSA 786
    rs169248991,2
    		C,F,H,--17095596(+) TCTGAT/CGCTAC 1 -- ds500127Minor allele frequency- C:0.18NA NS EA CSA WA EU 3425
    rs1882470661,2
    		--17095686(+) ATGACA/GCCAAA 1 -- ds50010--------
    rs1168494251,2
    		C,F,--17095699(+) AAACAC/AAAAGG 1 -- ds50011Minor allele frequency- A:0.02EA 120
    rs1917830571,2
    		C,--17095934(+) AACATC/GCTTTT 2 -- ds50010--------
    rs1474523421,2
    		C,F,--17095967(+) TTGAGT/AACACA 2 -- ut31 ds50011Minor allele frequency- A:0.01EU 1291
    rs110241481,2
    		C,F,A,H,--17096059(+) ATACTG/AGTCCC 2 -- int1 ds500127Minor allele frequency- A:0.35NA NS EA WA CSA 2727
    rs1840953791,2
    		--17096084(+) CAGAAG/TCTCCC 2 -- ds5001 int10--------
    rs71256071,2
    		C,F,A,H,--17096150(+) AAACTA/TCTGAA 2 -- ds5001 int123Minor allele frequency- T:0.31EA NA NS WA CSA 1509

    HapMap Linkage Disequilibrium report for RPS13 (17095936 - 17099334 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RPS13: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPS13
    DNA2.0 Custom Variant and Variant Library Synthesis for RPS13

    Disorders / Diseases
    for RPS13 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RPS13 for disorders           About GeneDecksing

    OMIM gene information: 180476    OMIM disorders: --

    2 diseases for RPS13:    About MalaCards
    gastric cancer    malaria

    1 Novoseek disease relationship for RPS13 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 2 16761435 (2)


    Export disorders for RPS13 gene to outside databases

    Publications
    for RPS13 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RPS13 gene, integrated from 9 sources (see all 70):
    (articles sorted by number of sources associating them with RPS13)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and analysis of the human S13 ribosomal protein cDNA. (PubMed id 8332508)1, 2, 3 Chadeneau C.... Denis M.G. (1993)
    2. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. A map of 75 human ribosomal protein genes. (PubMed id 9582194)1, 3 Kenmochi N.... Page D.C. (1998)
    5. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699)1, 2 Vladimirov S.N.... Otto A. (1996)
    6. U14 snoRNAs are encoded in introns of human ribosomal protein S13 gene. (PubMed id 8920921)1, 2 Kenmochi N.... Tanaka T. (1996)
    7. Human ribosomal protein S13 regulates expression of its own gene at the splicing step by a feedback mechanism. (PubMed id 17881366)1, 9 Malygin A.A....Karpova G.G. (2007)
    8. Human ribosomal protein S13: cloning, expression, refolding, and structural stability. (PubMed id 15680243)1, 9 Malygin A....Karpova G. (2005)
    9. Ribosomal proteins S13 and L23 promote multidrug resistance in gastric cancer cells by suppressing drug-induced apoptosis. (PubMed id 15149863)1, 9 Shi Y....Fan D. (2004)
    10. The human EKC/KEOPS complex is recruited to Cullin2 ub iquitin ligases by the human tumour antigen PRAME. (PubMed id 22912744)1 Costessi A....Stunnenberg H.G. (2012)

    External Searches for RPS13 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing RPS13 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6207 HGNC: 10386 AceView: RPS13 Ensembl:ENSG00000110700 euGenes: HUgn6207
    ECgene: RPS13 Kegg: 6207 H-InvDB: RPS13

    Other Databases showing RPS13 gene

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    Specialized Databases showing RPS13 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    NameDescription
    PharmGKB entry for RPS13 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
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    IP news from LifeMap Sciences, Inc.)
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    		Patent Information for RPS13 gene:
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