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Aliases for RPS13 Gene

Aliases for RPS13 Gene

  • Ribosomal Protein S13 2 3
  • 40S Ribosomal Protein S13 2 3
  • S13 3

External Ids for RPS13 Gene

Previous GeneCards Identifiers for RPS13 Gene

  • GC11M018166
  • GC11M018039
  • GC11M017135
  • GC11M017060
  • GC11M017054
  • GC11M017055
  • GC11M016780
  • GC11M017095

Summaries for RPS13 Gene

Entrez Gene Summary for RPS13 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S15P family of ribosomal proteins. It is located in the cytoplasm. The protein has been shown to bind to the 5.8S rRNA in rat. The gene product of the E. coli ortholog (ribosomal protein S15) functions at early steps in ribosome assembly. This gene is co-transcribed with two U14 small nucleolar RNA genes, which are located in its third and fifth introns. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS13 Gene

RPS13 (Ribosomal Protein S13) is a Protein Coding gene. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include structural constituent of ribosome and mRNA binding.

Gene Wiki entry for RPS13 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS13 Gene

Genomics for RPS13 Gene

Regulatory Elements for RPS13 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RPS13 Gene

Start:
17,074,389 bp from pter
End:
17,077,787 bp from pter
Size:
3,399 bases
Orientation:
Minus strand

Genomic View for RPS13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPS13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS13 Gene

Proteins for RPS13 Gene

  • Protein details for RPS13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62277-RS13_HUMAN
    Recommended name:
    40S ribosomal protein S13
    Protein Accession:
    P62277
    Secondary Accessions:
    • B2R549
    • P19116
    • Q02546
    • Q29200
    • Q498Y0

    Protein attributes for RPS13 Gene

    Size:
    151 amino acids
    Molecular mass:
    17222 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS13 Gene

neXtProt entry for RPS13 Gene

Proteomics data for RPS13 Gene at MOPED

Post-translational modifications for RPS13 Gene

  • Ubiquitination at Lys9, Lys27, Lys34, Lys39, Lys43, Lys70, and Lys78
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS13 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RPS13 Gene

Domains for RPS13 Gene

Gene Families for RPS13 Gene

HGNC:
  • RPS :S ribosomal proteins

Protein Domains for RPS13 Gene

Suggested Antigen Peptide Sequences for RPS13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62277

UniProtKB/Swiss-Prot:

RS13_HUMAN :
  • P62277
Family:
  • Belongs to the ribosomal protein S15P family.
genes like me logo Genes that share domains with RPS13: view

Function for RPS13 Gene

Molecular function for RPS13 Gene

GENATLAS Biochemistry:
60S ribosomal protein S13

Gene Ontology (GO) - Molecular Function for RPS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003729 mRNA binding IDA 17881366
GO:0003735 structural constituent of ribosome IBA --
GO:0005515 protein binding IPI 12054647
GO:0044822 poly(A) RNA binding IDA 22681889
GO:0070181 small ribosomal subunit rRNA binding IBA --
genes like me logo Genes that share ontologies with RPS13: view
genes like me logo Genes that share phenotypes with RPS13: view

miRNA for RPS13 Gene

miRTarBase miRNAs that target RPS13

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPS13

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPS13 Gene

Localization for RPS13 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS13 Gene COMPARTMENTS Subcellular localization image for RPS13 gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA 17881366
GO:0005730 nucleolus IDA 17881366
GO:0005829 cytosol TAS --
GO:0005840 ribosome NAS 8332508
genes like me logo Genes that share ontologies with RPS13: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS13 Gene

Pathways for RPS13 Gene

SuperPathways for RPS13 Gene

Superpath Contained pathways
1 Influenza Viral RNA Transcription and Replication
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 CFTR translational fidelity (class I mutations)
.54
4 Disease
5 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
genes like me logo Genes that share pathways with RPS13: view

Pathways by source for RPS13 Gene

1 KEGG pathway for RPS13 Gene
1 GeneGo (Thomson Reuters) pathway for RPS13 Gene

Gene Ontology (GO) - Biological Process for RPS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
GO:0006415 translational termination TAS --
genes like me logo Genes that share ontologies with RPS13: view

Transcripts for RPS13 Gene

mRNA/cDNA for RPS13 Gene

Unigene Clusters for RPS13 Gene

Ribosomal protein S13:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPS13

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS13 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6
SP1:
SP2: - - -
SP3:
SP4:
SP5:

Relevant External Links for RPS13 Gene

GeneLoc Exon Structure for
RPS13
ECgene alternative splicing isoforms for
RPS13

Expression for RPS13 Gene

mRNA expression in normal human tissues for RPS13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for RPS13 Gene

This gene is overexpressed in Nasal epithelium (11.8) and Tlymphocyte (6.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS13 Gene

SOURCE GeneReport for Unigene cluster for RPS13 Gene Hs.446588

genes like me logo Genes that share expressions with RPS13: view

Expression partners for RPS13 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS13 Gene

Orthologs for RPS13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS13 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPS13 35
  • 90.51 (n)
  • 100 (a)
-- 36
  • 98 (a)
OneToMany
RPS13 36
  • 100 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RPS13 35
  • 91.39 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Rps13 35
  • 86.98 (n)
  • 100 (a)
Rps13 16
Rps13 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPS13 35
  • 99.78 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia RPS13 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPS13 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPS13 35
  • 81.68 (n)
  • 100 (a)
RPS13 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPS13 36
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rps13 35
  • 80.79 (n)
  • 99.34 (a)
African clawed frog
(Xenopus laevis)
Amphibia rps13-prov 35
zebrafish
(Danio rerio)
Actinopterygii rps13 35
  • 78.15 (n)
  • 97.35 (a)
rps13 36
  • 97 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13839 35
fruit fly
(Drosophila melanogaster)
Insecta RpS13 37
  • 87 (a)
RpS13 35
  • 71.08 (n)
  • 87.42 (a)
RpS13 36
  • 87 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta RS13_ANOGA 35
  • 68.21 (n)
  • 84.11 (a)
worm
(Caenorhabditis elegans)
Secernentea rps-13 37
  • 76 (a)
rps-13 35
  • 68.43 (n)
  • 76.16 (a)
rps-13 36
  • 76 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL030W 35
  • 66.44 (n)
  • 78.67 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F18040g 35
  • 67.11 (n)
  • 78 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS13 35
  • 66.22 (n)
  • 78 (a)
RPS13 36
  • 77 (a)
OneToOne
RPS13 38
thale cress
(Arabidopsis thaliana)
eudicotyledons RPS13A 35
  • 66 (n)
  • 78.81 (a)
rice
(Oryza sativa)
Liliopsida Os.15168 35
Os08g0117300 35
  • 62.69 (n)
  • 72.85 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.14203 35
corn
(Zea mays)
Liliopsida Zm.3223 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14352 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03038 35
  • 68.21 (n)
  • 80.79 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps13 35
  • 65.56 (n)
  • 74.83 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11176 36
  • 88 (a)
OneToOne
Species with no ortholog for RPS13:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPS13 Gene

ENSEMBL:
Gene Tree for RPS13 (if available)
TreeFam:
Gene Tree for RPS13 (if available)

Paralogs for RPS13 Gene

genes like me logo Genes that share paralogs with RPS13: view

No data available for Paralogs for RPS13 Gene

Variants for RPS13 Gene

Sequence variations from dbSNP and Humsavar for RPS13 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs11024147 -- 17,074,018(+) ATTAC(G/T)TTTGC downstream-variant-500B
rs11024150 -- 17,078,718(+) CGCCT(C/G)GGCCT upstream-variant-2KB
rs12420958 -- 17,078,885(+) AGGAG(G/T)CTGAG upstream-variant-2KB
rs12577388 -- 17,079,608(+) CCCCC(A/C/T)AAAAA upstream-variant-2KB
rs16924899 -- 17,074,049(+) TCTGA(C/T)GCTAC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RPS13 Gene

Variant ID Type Subtype PubMed ID
nsv467711 CNV Gain 19166990

Relevant External Links for RPS13 Gene

HapMap Linkage Disequilibrium report
RPS13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS13 Gene

Disorders for RPS13 Gene

(1) Novoseek inferred disease relationships for RPS13 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 2
genes like me logo Genes that share disorders with RPS13: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Genatlas and External Links for RPS13 Gene

Publications for RPS13 Gene

  1. Cloning and analysis of the human S13 ribosomal protein cDNA. (PMID: 8332508) Chadeneau C. … Denis M.G. (Nucleic Acids Res. 1993) 2 3 4
  2. Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PMID: 8706699) Vladimirov S.N. … Otto A. (Eur. J. Biochem. 1996) 3 4
  3. U14 snoRNAs are encoded in introns of human ribosomal protein S13 gene. (PMID: 8920921) Kenmochi N. … Tanaka T. (Biochem. Biophys. Res. Commun. 1996) 3 4
  4. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3
  5. Ribosomal proteins S13 and L23 promote multidrug resistance in gastric cancer cells by suppressing drug-induced apoptosis. (PMID: 15149863) Shi Y. … Fan D. (Exp. Cell Res. 2004) 3 23

Products for RPS13 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate RPS13
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for RPS13
    • Block miRNA regulation of RPS13 using miScript Target Protectors

    Sources for RPS13 Gene

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